Supplementary Table 2. Genes selected by FADA as the most discriminant between tumoral and normal prostate samples

GO Biological Process GO Molecular Function GO Cellular Component GeneID T-test q-val Gene Symbol Gene Title Description Description Description Pathway

serine-type endopeptidase inhibitor activity /// endopeptidase inhibitor serpin peptidase inhibitor, clade activity /// serine-type endopeptidase 213572_s_at -6.753 2.213E-05 SERPINB1 B (ovalbumin), member 1 --- inhibitor activity cytoplasm ---

ion transport /// cellular defense response /// positive regulation of T-cell, immune regulator 1, cell proliferation /// proton plasma membrane /// integral to ATPase, H+ transporting, transport /// transport /// proton transporter activity /// hydrogen ion plasma membrane /// membrane /// 204158_s_at -5.729 8.585E-05 TCIRG1 lysosomal V0 subunit A3 transport transporter activity integral to membrane ---

chemotaxis /// cell adhesion /// homophilic cell adhesion /// nervous system development /// cell differentiation /// positive roundabout, axon guidance regulation of axonogenesis /// receptor activity /// axon guidance integral to plasma membrane /// cell receptor, homolog 1 development /// nervous system receptor activity /// identical protein surface /// membrane /// integral to 213194_at -6.168 4.441E-05 ROBO1 (Drosophila) development binding /// protein binding membrane ---

structural molecule activity /// nucleus /// intermediate filament /// protein binding /// microtubule cytoplasmic dynein complex /// 203411_s_at -5.297 1.636E-04 LMNA lamin A/C --- motor activity /// motor activity microtubule /// dynein complex ---

transcription factor activity /// skeletal development /// sequence-specific DNA binding /// v-ets erythroblastosis virus E26 regulation of transcription, DNA- DNA binding /// transcription factor Smooth_muscle_contrac 201329_s_at -5.807 7.442E-05 ETS2 oncogene homolog 2 (avian) dependent activity /// DNA binding nucleus tion nucleotide binding /// catalytic activity /// 6-phosphofructo-2-kinase activity /// 6-phosphofructo-2-kinase activity /// fructose-2,6-bisphosphate 2-phosphatase activity /// fructose- 2,6-bisphosphate 2-phosphatase fructose 2,6-bisphosphate activity /// ATP binding /// kinase Fructose and mannose 6-phosphofructo-2- metabolism /// fructose 2,6- activity /// transferase activity /// metabolism /// Fructose kinase/fructose-2,6- bisphosphate metabolism /// hydrolase activity /// identical and mannose 202464_s_at -5.034 2.458E-04 PFKFB3 biphosphatase 3 metabolism protein binding --- metabolism

nucleotide binding /// DNA binding /// double-stranded DNA binding /// double-stranded DNA binding /// single-stranded DNA binding /// single-stranded DNA binding /// DNA replication /// DNA RNA binding /// RNA binding /// replication /// RNA processing /// protein binding /// identical protein regulation of translation /// binding /// magnesium ion binding RNA binding motif, single cytokine and chemokine /// protein serine/threonine kinase stranded interacting protein 1 /// mediated signaling pathway /// activity /// ATP binding /// nucleic chromosome 2 open reading regulation of protein complex acid binding /// magnesium ion frame 12 /// region containing disassembly /// protein amino binding /// protein kinase activity /// chromosome 2 open reading acid phosphorylation /// DNA protein serine/threonine kinase RBMS1 /// frame 12; RNA binding motif, replication /// protein amino acid activity /// protein binding /// ATP C2orf12 /// single stranded interacting phosphorylation /// signal binding /// kinase activity /// 215127_s_at -5.066 2.351E-04 LOC648293 protein 1 transduction transferase activity nucleus /// nucleus ---

transcription /// regulation of transcription, DNA-dependent /// negative regulation of NGFI-A binding protein 1 transcription /// regulation of transcriptional repressor activity /// 209272_at -6.317 3.885E-05 NAB1 (EGR1 binding protein 1) transcription, DNA-dependent transcriptional repressor activity nucleus /// nucleus --- schwannomin interacting 204030_s_at -6.382 3.490E-05 SCHIP1 protein 1 ------cytoplasm --- immune response /// cell surface receptor linked signal CD59 molecule, complement transduction /// blood coagulation protein binding /// GPI anchor membrane fraction /// plasma 200984_s_at -5.554 1.108E-04 CD59 regulatory protein /// defense response binding membrane /// membrane --- nuclear envelope /// cytoplasm /// BCL2/adenovirus E1B 19kDa apoptosis /// anti-apoptosis /// GTPase activator activity /// calcium intracellular membrane-bound 209308_s_at -6.634 2.510E-05 BNIP2 interacting protein 2 apoptosis ion binding /// protein binding organelle ---

phospholipase inhibitor activity /// phospholipase inhibitor activity /// calcium ion binding /// calcium- dependent phospholipid binding /// soluble fraction /// plasma Prostaglandin_synthesis 201590_x_at -5.916 6.118E-05 ANXA2 annexin A2 skeletal development cytoskeletal protein binding membrane _regulation

plasma membrane /// integral to plasma membrane /// caveolar membrane /// caveolar membrane /// Integrin- protein binding /// protein lipid raft /// perinuclear region /// mediated_cell_adhesion 203323_at -6.351 3.721E-05 CAV2 caveolin 2 --- homodimerization activity membrane /// integral to membrane _KEGG

Golgi membrane /// endoplasmic Integrin- reticulum /// integral to plasma mediated_cell_adhesion structural molecule activity /// membrane /// membrane /// integral _KEGG /// Integrin- caveolin 1, caveolae protein, cholesterol transport /// protein binding /// cholesterol to membrane /// caveolar membrane mediated_cell_adhesion 203065_s_at -5.982 5.829E-05 CAV1 22kDa cholesterol homeostasis binding /// caveolar membrane /// lipid raft _KEGG nuclear envelope /// plasma fer-1-like 3, myoferlin (C. membrane /// integral to membrane 201798_s_at -5.295 1.636E-04 FER1L3 elegans) muscle contraction /// circulation --- /// membrane ---

membrane fraction /// endoplasmic ion transport /// chemotaxis /// reticulum /// endoplasmic reticulum proteolipid protein 2 (colonic cytokine and chemokine protein binding /// ion transporter membrane /// plasma membrane /// 201136_at -5.399 1.401E-04 PLP2 epithelium-enriched) mediated signaling pathway activity /// chemokine binding integral to membrane /// membrane --- regulation of progression through calcium ion binding /// growth factor cell cycle /// cell cycle /// signal activity /// protein homodimerization transduction /// cell-cell signaling activity /// S100 beta binding /// /// axonogenesis /// cell S100 alpha binding /// calcium- proliferation /// positive dependent protein binding /// protein S100 calcium binding protein regulation of fibroblast binding /// calcium ion binding /// ruffle /// nucleus /// nuclear Prostaglandin_synthesis 217728_at -6.577 2.637E-05 S100A6 A6 (calcyclin) proliferation /// cell cycle calcium ion binding envelope /// cytoplasm /// cytoplasm _regulation development /// cell death /// negative regulation of cell membrane fraction /// membrane /// 203729_at -5.347 1.505E-04 EMP3 epithelial membrane protein 3 proliferation /// cell growth --- integral to membrane --- coronin, actin binding protein, phagocytosis /// signal 221676_s_at -6.067 5.213E-05 CORO1C 1C transduction actin binding actin cytoskeleton --- Smooth_muscle_contrac nucleotide binding /// structural tion /// constituent of cytoskeleton /// Smooth_muscle_contrac AFFX- protein binding /// ATP binding /// cytoskeleton /// actin filament /// tion /// HSAC07/X00351 structural molecule activity /// TIP60 histone acetyltransferase Striated_muscle_contrac _5_at -5.296 1.636E-04 ACTB actin, beta --- protein binding complex tion

lysosomal associated protein transmembrane 4 beta /// lysosomal associated protein 208029_s_at -6.207 4.242E-05 LAPTM4B transmembrane 4 beta ------integral to membrane ---

G_Protein_Signaling /// A kinase (PRKA) anchor G_Protein_Signaling /// AKAP2 /// protein 2 /// PALM2-AKAP2 G_Protein_Signaling /// 202760_s_at -6.23 4.242E-05 PALM2-AKAP2 protein regulation of cell shape kinase activity /// enzyme binding membrane G_Protein_Signaling

nucleotide binding /// 5'-nucleotidase activity /// zinc ion binding /// Purine metabolism /// hydrolase activity, acting on ester Pyrimidine metabolism bonds /// metal ion binding /// GPI /// Nicotinate and DNA metabolism /// nucleotide anchor binding /// 5'-nucleotidase nicotinamide 203939_at -5.15 2.046E-04 NT5E 5'-nucleotidase, ecto (CD73) catabolism activity /// hydrolase activity membrane fraction /// membrane metabolism

fasciculation and elongation cell adhesion /// nervous system 203562_at -6.61 2.523E-05 FEZ1 protein zeta 1 (zygin I) development /// axon guidance protein binding ------squamous cell carcinoma endoplasmic reticulum /// 218854_at -5.984 5.829E-05 SART2 antigen recognized by T cells 2 ------membrane /// integral to membrane ---

serine-type endopeptidase inhibitor nervous system development /// activity /// heparin binding /// serpin peptidase inhibitor, clade cell differentiation /// regulation endopeptidase inhibitor activity /// E (nexin, plasminogen activator of proteolysis /// regulation of cell serine-type endopeptidase inhibitor 212190_at -5.191 1.906E-04 SERPINE2 inhibitor type 1), member 2 migration /// development activity /// heparin binding extracellular region ---

Circadian_Exercise /// Glutathione metabolism anti-apoptosis /// central nervous /// Metabolism of system development /// glutathione transferase activity /// xenobiotics by 200824_at -5.955 5.829E-05 GSTP1 glutathione S-transferase pi metabolism transferase activity cytoplasm cytochrome P450

proteolysis /// induction of apoptosis /// caspase activation /// cell cycle /// signal transduction /// regulation of apoptosis /// negative regulation of progression through cell cycle /// protein binding /// caspase activator positive regulation of interleukin- activity /// caspase activity /// Pyrin 1 beta secretion /// positive domain binding /// protein PYD and CARD domain regulation of caspase activity /// homodimerization activity /// protein intracellular /// cytoplasm /// 221666_s_at -5.229 1.779E-04 PYCARD containing apoptosis binding cytoplasm --- rRNA processing /// small GTPase mediated signal ADP-ribosylation factor-like transduction /// ribosome nucleotide binding /// GTPase 202207_at -6.256 4.215E-05 ARL4C 4C biogenesis activity /// GTP binding intracellular /// nucleus /// nucleus ---

negative regulation of transcription from RNA polymerase II promoter /// transcription /// regulation of transcription, DNA-dependent /// development /// ectoderm and DNA binding /// zinc ion binding /// mesoderm interaction /// sensory metal ion binding /// nucleic acid 213139_at -7.666 7.060E-06 SNAI2 snail homolog 2 (Drosophila) perception of sound binding intracellular /// nucleus /// nucleus ---

intracellular signaling cascade /// protein binding /// phosphoinositide 205573_s_at -5.573 1.088E-04 SNX7 sorting nexin 7 protein transport /// transport binding ------establishment and/or maintenance of chromatin architecture /// transcription /// regulation of transcription, DNA-dependent /// regulation of Wnt receptor transcription factor 7-like 1 (T- signaling pathway /// regulation cell specific, HMG-box) /// of transcription, DNA-dependent transcription factor 7-like 1 (T- /// Wnt receptor signaling transcription factor activity /// DNA 221016_s_at -7.337 1.023E-05 TCF7L1 cell specific, HMG-box) pathway binding /// DNA binding nucleus /// nucleus ---

protein complex assembly /// vesicle docking during exocytosis membrane /// integral to membrane vesicle-associated membrane /// membrane fusion /// vesicle- /// synaptosome /// synapse /// 201336_at -5.359 1.492E-04 VAMP3 protein 3 (cellubrevin) mediated transport /// exocytosis protein binding integral to membrane --- prion protein (p27-30) (Creutzfeldt-Jakob disease, cytoplasm /// endoplasmic reticulum Gerstmann-Strausler-Scheinker copper ion homeostasis /// copper ion binding /// microtubule /// Golgi apparatus /// plasma syndrome, fatal familial response to oxidative stress /// binding /// GPI anchor binding /// membrane /// extrinsic to membrane 201300_s_at -5.341 1.518E-04 PRNP insomnia) metabolism tubulin binding /// lipid raft /// membrane ---

galactosyltransferase activity /// N-Glycan biosynthesis transferase activity, transferring /// Keratan sulfate UDP-Gal:betaGlcNAc beta 1,4- glycosyl groups /// manganese ion biosynthesis /// Glycan galactosyltransferase, binding /// metal ion binding /// structures - biosynthesis 221485_at -5.069 2.351E-04 B4GALT5 polypeptide 5 carbohydrate metabolism transferase activity membrane /// integral to membrane 1 protein binding /// zinc ion binding /// metal ion binding /// protein 211564_s_at -5.197 1.884E-04 PDLIM4 PDZ and LIM domain 4 --- binding ------small GTPase mediated signal 212724_at -5.95 5.829E-05 RND3 Rho family GTPase 3 transduction nucleotide binding /// GTP binding intracellular /// membrane ---

voltage-gated chloride channel activity /// protein binding /// ion transport /// chloride transport chloride ion binding /// ion channel /// cell differentiation /// negative activity /// voltage-gated ion channel soluble fraction /// cytoplasm /// regulation of cell migration /// activity /// chloride channel activity microvillus /// actin cytoskeleton /// 201560_at -5.455 1.284E-04 CLIC4 chloride intracellular channel 4 transport /// chloride transport /// chloride channel activity membrane --- 202073_at -5.254 1.719E-04 OPTN optineurin ------

Hypertrophy_model /// 200609_s_at -6.29 4.007E-05 WDR1 WD repeat domain 1 sensory perception of sound actin binding /// protein binding cytoskeleton Hypertrophy_model 202440_s_at -6.733 2.223E-05 ST5 suppression of tumorigenicity 5 ------Ribosomal_Proteins

intracellular protein transport /// ER to Golgi vesicle-mediated transport /// vesicle-mediated endoplasmic reticulum /// cytosol /// Sec23 homolog A (S. transport /// transport /// protein protein binding /// zinc ion binding COPII vesicle coat /// endoplasmic 204344_s_at -6.597 2.558E-05 SEC23A cerevisiae) transport /// protein binding reticulum ---

mitochondrion /// mitochondrial inner membrane /// integral to solute carrier family 25 transporter activity /// binding /// plasma membrane /// membrane /// (mitochondrial carrier, Aralar), calcium ion binding /// solute:cation mitochondrion /// integral to 203340_s_at -5.811 7.415E-05 SLC25A12 member 12 transport /// transport symporter activity membrane ---

structural constituent of ribosome /// protein biosynthesis /// negative protein binding /// transcription regulation of transcription /// corepressor activity /// RNA binding estrogen receptor signaling /// transcription factor binding /// Ribosomal_Proteins /// pathway /// RNA metabolism /// nucleotide binding /// nucleic acid ribosome /// nucleus /// Ribosomal_Proteins /// 216215_s_at -5.356 1.492E-04 RPL41 Ribosomal protein L41 regulation of cell proliferation binding /// RNA binding ribonucleoprotein complex Ribosomal_Proteins

rhodopsin-like receptor activity /// signal transduction /// G-protein receptor activity /// signal transducer coupled receptor protein activity /// G-protein coupled GPCRDB_Class_A_Rho 214104_at -6.215 4.242E-05 GPR161 G protein-coupled receptor 161 signaling pathway receptor activity membrane /// integral to membrane dopsin-like2

Ras protein signal transduction /// related RAS viral (r-ras) small GTPase mediated signal nucleotide binding /// GTPase G_Protein_Signaling /// 212647_at -5.181 1.934E-04 RRAS oncogene homolog transduction activity /// GTP binding intracellular /// membrane MAPK_Cascade

ion channel activity /// calcium ion transient receptor potential ion transport /// calcium ion binding /// store-operated calcium plasma membrane /// integral to cation channel, subfamily C, transport /// transport /// calcium channel activity /// calcium channel plasma membrane /// membrane /// 205803_s_at -5.618 1.005E-04 TRPC1 member 1 ion transport activity /// calcium channel activity integral to membrane --- DNA binding /// protein binding /// RAB guanine nucleotide endocytosis /// protein transport zinc ion binding /// metal ion 218310_at -6.818 2.065E-05 RABGEF1 exchange factor (GEF) 1 /// transport binding ------

cytochrome-b5 reductase activity /// oxidoreductase activity /// FAD electron transport /// electron binding /// NAD binding /// 220230_s_at -5.653 9.755E-05 CYB5R2 cytochrome b5 reductase 2 transport cytochrome-b5 reductase activity soluble fraction /// membrane --- lipid binding /// retinal binding /// retinol binding protein 1, vitamin A metabolism /// retinol binding /// binding /// retinoid 203423_at -6.162 4.465E-05 RBP1 cellular transport binding ------

cytosolic small ribosomal subunit inositol-3-phosphate synthase (sensu Eukaryota) /// intracellular /// activity /// structural constituent of ribosome /// small ribosomal myo-inositol biosynthesis /// ribosome /// nucleic acid binding /// subunit /// ribonucleoprotein phospholipid biosynthesis /// structural constituent of ribosome /// complex /// cytosolic small myo-inositol 1-phosphate protein biosynthesis /// protein isomerase activity /// RNA binding ribosomal subunit (sensu 222240_s_at -5.919 6.118E-05 ISYNA1 synthase A1 biosynthesis /// structural constituent of ribosome Eukaryota) Ribosomal_Proteins

rhodopsin-like receptor activity /// receptor activity /// G-protein coupled receptor activity, unknown ligand /// purinergic nucleotide signal transduction /// G-protein receptor activity, G-protein coupled coupled receptor protein /// signal transducer activity /// G- membrane /// integral to membrane GPCRDB_Class_A_Rho 219936_s_at -9.397 1.317E-06 GPR87 G protein-coupled receptor 87 signaling pathway protein coupled receptor activity /// integral to membrane dopsin-like

cell communication /// cell adhesion /// cell-matrix adhesion /// integrin-mediated signaling integrin complex /// membrane /// Integrin- pathway /// development /// cell receptor activity /// protein binding integral to membrane /// integrin mediated_cell_adhesion 204990_s_at -6.131 4.761E-05 ITGB4 integrin, beta 4 adhesion /// protein binding complex _KEGG

extracellular matrix (sensu Metazoa) /// cytoplasm /// microsome /// integral to plasma electron transport /// phosphate monooxygenase activity /// structural membrane /// intercellular junction transport /// cell-matrix adhesion molecule activity /// iron ion binding /// membrane /// integral to 204636_at -6.343 3.731E-05 COL17A1 collagen, type XVII, alpha 1 /// epidermis development /// heme binding membrane --- Calcium signaling pathway /// Cytokine- cytokine receptor interaction /// Apoptosis /// Dorso-ventral axis formation /// Axon guidance /// VEGF signaling pathway /// Focal adhesion /// Adherens junction /// Gap junction /// Hematopoietic cell lineage /// Long-term depression /// Regulation of actin cytoskeleton /// Insulin signaling pathway /// GnRH signaling pathway /// nucleotide binding /// protein- Type II diabetes mellitus protein amino acid tyrosine kinase activity /// receptor /// phosphorylation /// signal activity /// ephrin receptor activity /// Dentatorubropallidoluysi transduction /// transmembrane ATP binding /// transferase activity an atrophy (DRPLA) /// receptor protein tyrosine kinase /// protein kinase activity /// kinase Epithelial cell signaling signaling pathway /// activity /// transmembrane receptor integral to plasma membrane /// in Helicobacter pylori /// 203499_at -6.886 1.797E-05 EPHA2 EPH receptor A2 development protein tyrosine kinase activity membrane /// integral to membrane Colorectal cancer extracellular matrix (sensu cell adhesion /// epidermis structural molecule activity /// Metazoa) /// basement membrane /// 209270_at -6.635 2.510E-05 LAMB3 laminin, beta 3 development protein binding laminin-5 --- structural molecule activity /// protein binding /// identical protein binding /// structural molecule intermediate filament /// cytoskeleton organization and activity /// zinc ion binding /// metal intermediate filament /// 209016_s_at -6.23 4.242E-05 KRT7 keratin 7 biogenesis ion binding intracellular --- structural molecule activity /// structural constituent of cytoskeleton /// protein binding /// structural epidermis development /// constituent of muscle /// structural intermediate filament /// sarcomere organization /// cell constituent of cytoskeleton /// intermediate filament /// costamere proliferation /// cytoskeleton structural constituent of epidermis /// /// intermediate filament /// 205157_s_at -5.207 1.850E-04 KRT17 keratin 17 organization and biogenesis structural constituent of cytoskeleton intermediate filament ---

transcription /// apoptosis /// induction of apoptosis /// Notch signaling pathway /// development /// positive regulation of Notch signaling pathway /// negative regulation of transcription factor activity /// zinc transcription, DNA-dependent /// ion binding /// transcriptional positive regulation of activator activity /// transcriptional transcription, DNA-dependent /// repressor activity /// identical protein protein homotetramerization /// binding /// metal ion binding /// regulation of transcription, DNA- protein binding /// DNA binding /// 209863_s_at -6.889 1.797E-05 TP73L tumor protein p73-like dependent /// apoptosis DNA binding nucleus /// nucleus ---

structural molecule activity /// keratin 5 (epidermolysis bullosa epidermis development /// structural constituent of cytoskeleton intermediate filament /// simplex, Dowling- ectoderm development /// /// protein binding /// protein binding intermediate filament /// Meara/Kobner/Weber- cytoskeleton organization and /// structural molecule activity /// intermediate filament /// 201820_at -6.438 3.219E-05 KRT5 Cockayne types) biogenesis structural constituent of cytoskeleton intermediate filament --- cytoskeleton organization and biogenesis /// cell cycle arrest /// cell adhesion /// integrin-mediated signaling pathway /// actin cytoskeleton organization and biogenesis /// intermediate actin binding /// integrin binding /// filament cytoskeleton structural constituent of cytoskeleton organization and biogenesis /// /// structural constituent of basement membrane /// extracellular intermediate filament cytoskeleton /// calcium ion binding space /// cytoplasm /// cytoplasm /// cytoskeleton organization and /// protein binding /// protein C- cytoskeleton /// intercellular biogenesis /// intermediate terminus binding /// actin filament junction /// cytoplasmic membrane- filament cytoskeleton binding /// protein binding /// bound vesicle /// hemidesmosome 204455_at -7.744 6.745E-06 DST dystonin organization and biogenesis structural molecule activity /// basal plasma membrane ---

cysteine protease inhibitor activity /// structural molecule activity /// protein binding, bridging /// endopeptidase inhibitor activity /// peptide cross-linking /// endopeptidase inhibitor activity /// 204971_at -9.11 1.317E-06 CSTA cystatin A (stefin A) keratinocyte differentiation cysteine protease inhibitor activity cornified envelope /// intracellular ---

structural constituent of cytoskeleton keratin 14 (epidermolysis /// protein binding /// structural bullosa simplex, Dowling- constituent of epidermis /// structural intermediate filament /// 209351_at -6.025 5.602E-05 KRT14 Meara, Koebner) epidermis development molecule activity intermediate filament --- pleckstrin homology domain containing, family A (phosphoinositide binding phospholipid binding /// lipid 219024_at -5.055 2.372E-04 PLEKHA1 specific) member 1 --- binding nucleus /// membrane --- transcription factor activity /// transcription from RNA protein binding /// zinc ion binding 202504_at -6.089 5.084E-05 TRIM29 tripartite motif-containing 29 polymerase II promoter /// metal ion binding intracellular --- natural killer cell proliferation /// NK T cell proliferation /// transcription /// regulation of transcription factor activity /// transcription, DNA-dependent /// protein binding /// transcriptional positive regulation of activator activity /// sequence- E74-like factor 4 (ets domain transcription from RNA specific DNA binding /// DNA 31845_at -6.004 5.675E-05 ELF4 transcription factor) polymerase II promoter binding nucleus /// PML body --- protein folding /// response to unfolded protein /// protein folding /// response to unfolded nucleotide binding /// ATP binding protein /// response to unfolded /// unfolded protein binding /// ATP 205543_at -6.911 1.797E-05 HSPA4L heat shock 70kDa protein 4-like protein binding nucleus /// cytoplasm /// nucleus ---

protein complex assembly /// response to pest, pathogen or parasite /// barbed-end actin capping protein (actin filament capping /// barbed-end nucleus /// F-actin capping protein 201850_at -5.851 6.877E-05 CAPG filament), gelsolin-like actin filament capping actin binding complex --- cytoskeleton organization and biogenesis /// actomyosin structure organization and actin binding /// calmodulin binding cytoskeleton /// intercellular Smooth_muscle_contrac 201605_x_at -5.429 1.346E-04 CNN2 calponin 2 biogenesis /// actin binding junction tion receptor activity /// death receptor 212373_at -5.066 2.351E-04 FEM1B fem-1 homolog b (C. elegans) induction of apoptosis binding ------nucleic acid binding /// zinc ion 205018_s_at -5.032 2.458E-04 MBNL2 muscleblind-like 2 (Drosophila) --- binding ------

extracellular matrix (sensu receptor signaling protein activity /// Metazoa) /// integral to plasma fibronectin leucine rich protein binding, bridging /// protein membrane /// membrane /// integral 219250_s_at -5.461 1.279E-04 FLRT3 transmembrane protein 3 cell adhesion binding to membrane ---

structural constituent of cytoskeleton /// protein binding /// structural intermediate filament /// 204734_at -5.291 1.636E-04 KRT15 keratin 15 epidermis development molecule activity intermediate filament ---

cell adhesion /// homophilic cell cytoskeleton /// membrane /// 203780_at -5.241 1.758E-04 EVA1 epithelial V-like antigen 1 adhesion /// morphogenesis protein binding integral to membrane --- GABA-A receptor activity /// ion channel activity /// extracellular ligand-gated ion channel activity /// chloride channel activity /// neurotransmitter receptor activity /// integral to membrane /// gamma-aminobutyric acid chloride ion binding /// GABA-A postsynaptic membrane /// 205044_at -6.22 4.242E-05 GABRP (GABA) A receptor, pi ion transport /// transport receptor activity /// receptor activity membrane ---

Fatty acid metabolism /// gamma- Hexachlorocyclohexane degradation /// Tryptophan metabolism /// Arachidonic acid monooxygenase activity /// iron ion metabolism /// Linoleic binding /// oxygen binding /// heme acid metabolism /// binding /// metal ion binding /// Metabolism of cytochrome P450, family 4, unspecific monooxygenase activity endoplasmic reticulum /// xenobiotics by 210096_at -6.394 3.469E-05 CYP4B1 subfamily B, polypeptide 1 electron transport /// oxidoreductase activity microsome /// membrane cytochrome P450 Calcium signaling pathway /// Cytokine- cytokine receptor interaction /// Apoptosis /// Dorso-ventral axis formation /// Axon guidance /// VEGF signaling pathway /// Focal adhesion /// Adherens junction /// Gap junction /// Hematopoietic cell lineage /// Long-term depression /// Regulation of actin cytoskeleton /// Insulin signaling pathway /// GnRH nucleotide binding /// protein- signaling pathway /// fibroblast growth factor tyrosine kinase activity /// protein- Type II diabetes mellitus receptor 2 (bacteria-expressed tyrosine kinase activity /// receptor /// kinase, keratinocyte growth activity /// fibroblast growth factor Dentatorubropallidoluysi factor receptor, craniofacial protein amino acid receptor activity /// ATP binding /// an atrophy (DRPLA) /// dysostosis 1, Crouzon phosphorylation /// protein amino heparin binding /// transferase membrane /// membrane /// integral Epithelial cell signaling syndrome, Pfeiffer syndrome, acid phosphorylation /// cell activity /// protein kinase activity /// to membrane /// integral to in Helicobacter pylori /// 208228_s_at -6.443 3.219E-05 FGFR2 Jackson-Weiss syndrome) growth kinase activity membrane Colorectal cancer

proline rich Gla (G- extracellular region /// membrane /// carboxyglutamic acid) 4 integral to membrane /// integral to 207291_at -5.474 1.247E-04 PRRG4 (transmembrane) --- calcium ion binding membrane --- receptor activity /// hematopoietin/interferon-class immune response /// cell surface (D200-domain) cytokine receptor extracellular region /// interleukin-6 receptor linked signal activity /// interleukin-6 receptor receptor complex /// membrane /// interleukin 6 receptor /// transduction /// development /// activity /// enzyme binding /// integral to membrane /// integral to 205945_at -5.31 1.606E-04 IL6R interleukin 6 receptor cell proliferation protein binding plasma membrane ---

plasma membrane /// integral to melanoma cell adhesion cell adhesion /// morphogenesis plasma membrane /// membrane /// 211340_s_at -6.423 3.283E-05 MCAM molecule /// cell adhesion protein binding integral to membrane --- Glutathione metabolism glutathione transferase activity /// /// Metabolism of transferase activity /// glutathione xenobiotics by 204149_s_at -5.67 9.484E-05 GSTM4 glutathione S-transferase M4 metabolism transferase activity --- cytochrome P450

nucleotide binding /// transmembrane receptor protein tyrosine kinase activity /// receptor protein amino acid activity /// ATP binding /// phosphorylation /// signal transferase activity /// protein kinase receptor tyrosine kinase-like transduction /// development /// activity /// protein-tyrosine kinase integral to plasma membrane /// 205578_at -6.071 5.213E-05 ROR2 orphan receptor 2 development activity /// kinase activity membrane /// integral to membrane ---

catalytic activity /// 3',5'-cyclic- nucleotide phosphodiesterase activity /// 3',5'-cyclic-AMP phosphodiesterase 4A, cAMP- signal transduction /// signal phosphodiesterase activity /// 3',5'- specific (phosphodiesterase E2 transduction /// cyclic nucleotide cyclic-AMP phosphodiesterase membrane fraction /// soluble G_Protein_Signaling /// 204735_at -9.041 1.317E-06 PDE4A dunce homolog, Drosophila) metabolism activity /// hydrolase activity fraction /// insoluble fraction Purine metabolism

cell cycle /// cell cycle arrest /// negative regulation of cell proliferation /// negative regulation of S phase of mitotic membrane /// anchored to plasma 204457_s_at -5.567 1.089E-04 GAS1 growth arrest-specific 1 cell cycle /// cell cycle arrest GPI anchor binding membrane ---

endoplasmic reticulum /// microsome /// integral to plasma progesterone receptor receptor activity /// steroid binding membrane /// cell surface /// 201121_s_at -7.246 1.180E-05 PGRMC1 membrane component 1 --- /// lipid binding /// steroid binding membrane /// integral to membrane ---

chromosome 9 open reading 209821_at -5.646 9.755E-05 C9orf26 frame 26 (NF-HEV) ------nucleus ---

transcription /// regulation of transcription factor activity /// RNA transcription from RNA polymerase II transcription factor polymerase II promoter /// signal activity /// transcription factor serum response factor (c-fos transduction /// development /// binding /// sequence-specific DNA serum response element- regulation of transcription, DNA- binding /// protein binding /// DNA 202401_s_at -6.739 2.223E-05 SRF binding transcription factor) dependent binding nucleus /// nucleus --- transcription /// regulation of transcription, DNA-dependent /// WW domain containing regulation of transcription, DNA- 202133_at -5.953 5.829E-05 WWTR1 transcription regulator 1 dependent transcription coactivator activity nucleus /// nucleus ---

transcription /// regulation of transcription, DNA-dependent /// transcription factor activity /// regulation of transcription from transcription factor activity /// forkhead box O1A RNA polymerase II promoter /// sequence-specific DNA binding /// 202724_s_at -5.438 1.320E-04 FOXO1A (rhabdomyosarcoma) anti-apoptosis DNA binding nucleus ---

nucleotide binding /// magnesium ion binding /// protein protein amino acid serine/threonine kinase activity /// phosphorylation /// protein amino protein serine/threonine kinase acid phosphorylation /// muscle activity /// ATP binding /// ATP contraction /// regulation of heart binding /// transferase activity /// contraction /// regulation of small identical protein binding /// protein GTPase mediated signal binding /// protein kinase activity /// dystrophia myotonica-protein transduction /// protein kinase activity /// metal ion binding 37996_s_at -5.596 1.051E-04 DMPK kinase modification /// protein kinase activity ------

metalloendopeptidase activity /// integrin binding /// zinc ion binding /// metal ion binding /// peptidase extracellular matrix (sensu ADAM metallopeptidase with activity /// metallopeptidase activity Metazoa) /// extracellular matrix /// thrombospondin type 1 motif, 5 /// hydrolase activity /// extracellular matrix (sensu 219935_at -5.034 2.458E-04 ADAMTS5 (aggrecanase-2) proteolysis /// proteolysis metallopeptidase activity Metazoa) --- protein phosphatase 1, regulatory (inhibitor) subunit 201603_at -5.853 6.877E-05 PPP1R12A 12A regulation of muscle contraction signal transducer activity actin cytoskeleton ---

calcium:sodium antiporter activity /// ion transport /// sodium ion calcium ion binding /// calmodulin transport /// calcium ion transport binding /// sodium ion transporter /// calcium ion transport /// activity /// calcium ion transporter Calcium_regulation_in_ solute carrier family 8 muscle contraction /// cell activity /// antiporter activity /// heat cardiac_cells /// (sodium/calcium exchanger), communication /// transport /// shock protein binding /// sodium ion integral to plasma membrane /// Smooth_muscle_contrac 207053_at -6.489 3.019E-05 SLC8A1 member 1 sodium ion transport binding membrane /// integral to membrane tion signal transduction /// transforming growth factor, transforming growth factor beta receptor activity /// beta receptor III (betaglycan, receptor signaling pathway /// glycosaminoglycan binding /// membrane /// integral to membrane TGF_Beta_Signaling_Pa 204731_at -5.953 5.829E-05 TGFBR3 300kDa) development receptor activity /// integral to membrane thway

membrane /// integral to membrane Electron_Transport_Cha 219647_at -5.781 7.767E-05 POPDC2 popeye domain containing 2 ------/// integral to membrane in

Urea cycle and metabolism of amino groups /// Glycine, glycine amidinotransferase (L- glycine amidinotransferase activity serine and threonine arginine:glycine /// transferase activity /// glycine mitochondrion /// mitochondrial metabolism /// Arginine 216733_s_at -5.641 9.755E-05 GATM amidinotransferase) creatine biosynthesis amidinotransferase activity intermembrane space and proline metabolism G_Protein_Signaling /// G13_Signaling_Pathway /// Glycogen_Metabolism /// Calcium_regulation_in_ cardiac_cells /// Smooth_muscle_contrac tion /// G_Protein_Signaling /// G13_Signaling_Pathway /// Calcium_regulation_in_ cardiac_cells /// Smooth_muscle_contrac tion /// Calcium_regulation_in_ cardiac_cells /// Smooth_muscle_contrac tion /// G_Protein_Signaling /// G13_Signaling_Pathway /// G_Protein_Signaling /// G13_Signaling_Pathway /// protein binding /// N-terminal Glycogen_Metabolism myristoylation domain binding /// /// G-protein coupled receptor calcium ion binding /// protein Calcium_regulation_in_ protein signaling pathway /// G- binding /// calcium ion binding /// cardiac_cells /// calmodulin 1 (phosphorylase protein coupled receptor protein calcium ion binding /// protein cytoplasm /// plasma membrane /// Smooth_muscle_contrac 211985_s_at -5.276 1.668E-04 CALM1 kinase, delta) signaling pathway binding /// protein binding cytoplasm /// plasma membrane tion

protein folding /// muscle contraction /// transmembrane receptor protein tyrosine kinase structural constituent of eye lens /// signaling pathway /// visual unfolded protein binding /// protein 209283_at -7.811 6.745E-06 CRYAB crystallin, alpha B perception binding nucleus /// cytoplasm --- receptor activity /// sevenless signal transduction /// G-protein binding /// metabotropic glutamate, coupled receptor protein GABA-B-like receptor activity /// GPCRDB_Class_C_Met G protein-coupled receptor, signaling pathway /// visual signal transducer activity /// G- abotropic_glutamate_ph 203632_s_at -5.629 9.892E-05 GPRC5B family C, group 5, member B perception protein coupled receptor activity membrane /// integral to membrane eromone

nucleotide binding /// magnesium ion binding /// sodium:potassium- exchanging ATPase activity /// ATP binding /// monovalent inorganic cation transporter activity /// ATPase activity, coupled to transmembrane movement of ions, phosphorylative potassium ion transport /// sodium mechanism /// hydrolase activity /// ion transport /// metabolism /// hydrolase activity, acting on acid monovalent inorganic cation anhydrides, catalyzing transport /// ATP hydrolysis transmembrane movement of coupled proton transport /// sperm substances /// potassium ion binding sodium:potassium-exchanging motility /// hydrogen ion /// sodium ion binding /// catalytic ATPase complex /// membrane /// homeostasis /// transport /// ion activity /// sodium:potassium- integral to membrane /// integral to transport /// cation transport /// exchanging ATPase activity /// metal plasma membrane /// ATPase, Na+/K+ transporting, potassium ion transport /// sodium ion binding /// sodium:potassium- sodium:potassium-exchanging 203296_s_at -5.37 1.471E-04 ATP1A2 alpha 2 (+) polypeptide ion transport exchanging ATPase activity ATPase complex --- cell adhesion /// homophilic cell calcium ion binding /// protein 219737_s_at -5.285 1.645E-04 PCDH9 protocadherin 9 adhesion binding membrane /// integral to membrane --- cell-cell signaling /// sex determination /// sex steroid-5-alpha-reductase, alpha differentiation /// androgen 3-oxo-5-alpha-steroid 4- polypeptide 2 (3-oxo-5 alpha- metabolism /// male gonad dehydrogenase activity /// sterol 5- endoplasmic reticulum /// Bile acid biosynthesis /// steroid delta 4-dehydrogenase development /// cell alpha reductase activity /// microsome /// membrane /// integral Androgen and estrogen 206938_at -5.582 1.081E-04 SRD5A2 alpha 2) differentiation oxidoreductase activity to membrane metabolism regulation of progression through cell cycle /// signal transduction /// cell-cell signaling /// cell transforming growth factor beta proliferation /// organ receptor binding /// growth factor transforming growth factor, morphogenesis /// cell growth /// activity /// transforming growth 209747_at -5.236 1.772E-04 TGFB3 beta 3 growth factor beta receptor binding ------collagen type XIII /// cytoplasm /// 211343_s_at -7.696 7.025E-06 COL13A1 collagen, type XIII, alpha 1 phosphate transport --- plasma membrane ---

structural constituent of cytoskeleton actin cytoskeleton /// membrane /// 202920_at -5.754 8.283E-05 ANK2 ankyrin 2, neuronal signal transduction /// protein binding cytoskeleton ---

complement factor D activity /// complement factor D activity /// proteolysis /// proteolysis /// peptidase activity /// chaperone complement activation, binding /// unfolded protein binding alternative pathway /// innate /// chaperone binding /// serine-type immune response /// caspase endopeptidase activity /// hydrolase activation /// immune response /// activity /// ATP binding /// unfolded protein folding /// response to protein binding /// serine-type unfolded protein /// complement peptidase activity /// unfolded mitochondrion /// mitochondrion /// Complement and 205382_s_at -6.213 4.242E-05 CFD complement factor D (adipsin) activation /// caspase activation protein binding mitochondrion coagulation cascades

G_Protein_Signaling /// G_Protein_Signaling /// G_Protein_Signaling /// Calcium_regulation_in_ signal transduction /// G-protein nucleotide binding /// GTPase cardiac_cells /// coupled receptor protein activity /// receptor signaling protein Calcium_regulation_in_ guanine nucleotide binding signaling pathway /// G-protein activity /// GTP binding /// signal nuclear envelope /// endoplasmic cardiac_cells /// protein (G protein), alpha z coupled receptor protein transducer activity /// guanyl reticulum /// plasma membrane /// Calcium_regulation_in_ 204993_at -5.527 1.160E-04 GNAZ polypeptide signaling pathway nucleotide binding membrane cardiac_cells small GTPase mediated signal 219167_at -5.256 1.715E-04 RASL12 RAS-like, family 12 transduction nucleotide binding /// GTP binding membrane --- copper ion transporter activity /// ion transport /// copper ion iron ion binding /// copper ion transport /// iron ion transport /// binding /// oxidoreductase activity /// 203903_s_at -5.02 2.485E-04 HEPH hephaestin transport metal ion binding membrane /// integral to membrane --- Calcium signaling pathway /// Cytokine- cytokine receptor interaction /// Apoptosis /// Dorso-ventral axis formation /// Axon guidance /// VEGF signaling pathway /// Focal adhesion /// Adherens junction /// Gap junction /// Hematopoietic cell lineage /// Long-term depression /// Regulation nucleotide binding /// protein- of actin cytoskeleton /// tyrosine kinase activity /// receptor Insulin signaling activity /// fibroblast growth factor pathway /// GnRH MAPKKK cascade /// skeletal receptor activity /// fibroblast growth signaling pathway /// development /// protein amino factor receptor activity /// protein Type II diabetes mellitus acid phosphorylation /// fibroblast binding /// ATP binding /// heparin /// growth factor receptor signaling binding /// transferase activity /// Dentatorubropallidoluysi pathway /// cell growth /// protein protein kinase activity /// protein- membrane fraction /// integral to an atrophy (DRPLA) /// fibroblast growth factor amino acid phosphorylation /// tyrosine kinase activity /// ATP plasma membrane /// membrane /// Epithelial cell signaling receptor 1 (fms-related tyrosine fibroblast growth factor receptor binding /// heparin binding /// kinase integral to membrane /// integral to in Helicobacter pylori /// 211535_s_at -7.062 1.472E-05 FGFR1 kinase 2, Pfeiffer syndrome) signaling pathway activity membrane Colorectal cancer

methyltransferase activity /// betaine-homocysteine homocysteine S-methyltransferase 219902_at -7.765 6.745E-06 BHMT2 methyltransferase 2 --- activity /// transferase activity ------

205475_at -5.717 8.796E-05 SCRG1 scrapie responsive protein 1 nervous system development --- extracellular space --- filamin C, gamma (actin actin binding /// protein binding /// 207876_s_at -7.21 1.180E-05 FLNC binding protein 280) --- actin binding actin cytoskeleton /// cytoskeleton --- Smooth_muscle_contrac tion /// Striated_muscle_contrac tion /// nucleotide binding /// structural Smooth_muscle_contrac constituent of cytoskeleton /// tion /// protein binding /// ATP binding /// Striated_muscle_contrac 205132_at -8.113 4.812E-06 ACTC1 actin, alpha, cardiac muscle 1 --- structural molecule activity cytoskeleton /// actin filament tion

calcium channel regulator activity /// calcium ion transport /// muscle protein binding /// ATPase inhibitor contraction /// circulation /// activity /// calcium channel regulator smooth endoplasmic reticulum /// Calcium_regulation_in_ 204940_at -8.084 4.812E-06 PLN phospholamban calcium ion transport activity membrane /// integral to membrane cardiac_cells

voltage-gated ion channel activity /// ATP-activated inward rectifier potassium channel activity /// potassium ion binding /// ion channel ion transport /// potassium ion activity /// inward rectifier potassium membrane fraction /// voltage-gated potassium inwardly-rectifying transport /// transport /// channel activity /// inward rectifier potassium channel complex /// 205304_s_at -5.08 2.308E-04 KCNJ8 channel, subfamily J, member 8 potassium ion transport potassium channel activity membrane /// integral to membrane ---

protein amino acid phosphorylation /// cell-matrix adhesion /// integrin-mediated nucleotide binding /// protein Integrin- signaling pathway /// integrin- serine/threonine kinase activity /// mediated_cell_adhesion mediated signaling pathway /// protein-tyrosine kinase activity /// _KEGG /// protein amino acid ATP binding /// kinase activity /// RNA_transcription_Rea phosphorylation /// integrin- transferase activity /// protein kinase ctome /// Integrin- mediated signaling pathway /// activity /// protein serine/threonine mediated_cell_adhesion cell-matrix adhesion /// integrin- kinase activity /// protein _KEGG /// mediated signaling pathway /// serine/threonine kinase activity /// RNA_transcription_Rea 201234_at -5.842 6.956E-05 ILK integrin-linked kinase cell proliferation ATP binding cytoplasm ctome

transcription /// regulation of double-stranded DNA binding /// transcription, DNA-dependent /// transcription factor activity /// transcription from RNA sequence-specific DNA binding /// polymerase II promoter /// protein dimerization activity /// DNA 204753_s_at -5.425 1.358E-04 HLF hepatic leukemia factor development /// rhythmic process binding /// DNA binding nucleus /// nucleus --- carboxylesterase activity /// serine carboxylesterase 1 esterase activity /// serine esterase Irinotecan_pathway_Pha (monocyte/macrophage serine activity /// hydrolase activity /// extracellular space /// endoplasmic rmGKB /// Alkaloid 209616_s_at -6.309 3.885E-05 CES1 esterase 1) metabolism /// response to toxin carboxylesterase activity reticulum biosynthesis II

retinoic acid receptor responder 209496_at -5.578 1.083E-04 RARRES2 (tazarotene induced) 2 retinoid metabolism ------extracellular matrix (sensu extracellular matrix structural Metazoa) /// cytoplasm /// phosphate transport /// cell constituent /// protein binding /// extracellular matrix (sensu 204163_at -6.033 5.529E-05 EMILIN1 elastin microfibril interfacer 1 adhesion /// cell adhesion protein binding Metazoa) ---

chromatin remodeling /// transcription /// regulation of transcription from RNA polymerase II promoter /// positive regulation of transcription coactivator activity /// SWI/SNF related, matrix transcription, DNA-dependent /// receptor binding /// transcription associated, actin dependent regulation of transcription, DNA- factor binding /// transcription regulator of chromatin, dependent /// chromatin regulator activity /// nuclear nucleus /// nucleoplasm /// 204099_at -6.693 2.304E-05 SMARCD3 subfamily d, member 3 modification hormone receptor binding SWI/SNF complex /// nucleus --- muscle contraction /// Striated_muscle_contrac cytoskeleton organization and structural molecule activity /// tion /// biogenesis /// regulation of heart structural constituent of cytoskeleton intermediate filament /// Striated_muscle_contrac 202222_s_at -5.481 1.230E-04 DES desmin contraction /// protein binding intermediate filament tion protein phosphatase 1, regulatory (inhibitor) subunit regulation of muscle contraction 201957_at -6.196 4.271E-05 PPP1R12B 12B /// signal transduction enzyme activator activity ------

nucleotide binding /// motor activity myosin, heavy polypeptide 11, /// actin binding /// calmodulin muscle myosin /// striated muscle 201496_x_at -5.356 1.492E-04 MYH11 smooth muscle striated muscle contraction binding /// ATP binding thick filament /// myosin ---

ion transport /// potassium ion ion channel activity /// calcium- transport /// smooth muscle activated potassium channel activity potassium large conductance contraction /// synaptic /// potassium channel regulator calcium-activated channel, transmission /// transport /// activity /// calcium-activated 209948_at -6.906 1.797E-05 KCNMB1 subfamily M, beta member 1 potassium ion transport potassium channel activity membrane /// integral to membrane --- Glycine, serine and threonine metabolism /// Arginine and proline metabolism /// Histidine metabolism /// Tyrosine metabolism /// amine oxidase activity /// electron mitochondrion /// mitochondrial Phenylalanine carrier activity /// oxidoreductase envelope /// membrane /// integral to metabolism /// 204041_at -5.948 5.829E-05 MAOB monoamine oxidase B electron transport activity membrane Tryptophan metabolism G-protein coupled receptor protein signaling pathway /// frizzled signaling pathway /// development /// signal receptor activity /// non-G-protein transduction /// cell surface coupled 7TM receptor activity /// G- receptor linked signal protein coupled receptor activity /// plasma membrane /// integral to frizzled homolog 7 transduction /// Wnt receptor Wnt receptor activity /// signal membrane /// membrane /// integral 203706_s_at -5.082 2.308E-04 FZD7 (Drosophila) signaling pathway transducer activity to membrane Wnt_signaling regulation of smooth muscle contraction /// actomyosin calponin 1, basic, smooth structure organization and Smooth_muscle_contrac 203951_at -5.308 1.606E-04 CNN1 muscle biogenesis actin binding /// calmodulin binding --- tion

nucleobase, nucleoside, nucleotide and nucleic acid metabolism /// signal transduction dihydropyrimidinase activity /// 201431_s_at -6.078 5.187E-05 DPYSL3 dihydropyrimidinase-like 3 /// nervous system development hydrolase activity ------

transcription /// regulation of transcription factor activity /// RNA transcription, DNA-dependent /// polymerase II transcription factor transcription from RNA activity /// transcription coactivator MADS box transcription polymerase II promoter /// activity /// sequence-specific DNA enhancer factor 2, polypeptide nervous system development /// binding /// DNA binding /// 209199_s_at -5.144 2.064E-04 MEF2C C (myocyte enhancer factor 2C) muscle development transcription factor activity nucleus ---

monooxygenase activity /// iron ion prostaglandin biosynthesis /// binding /// prostaglandin-I synthase Eicosanoid_Synthesis /// electron transport /// lipid activity /// isomerase activity /// Prostaglandin_synthesis prostaglandin I2 (prostacyclin) metabolism /// fatty acid heme binding /// metal ion binding endoplasmic reticulum /// _regulation /// synthase /// prostaglandin I2 biosynthesis /// lipid biosynthesis /// prostaglandin-I synthase activity membrane /// integral to membrane Arachidonic acid 208131_s_at -7.138 1.310E-05 PTGIS (prostacyclin) synthase /// prostaglandin metabolism /// oxidoreductase activity /// microsome metabolism transcription /// regulation of transcription from RNA transcription factor activity /// polymerase II promoter /// transcription coactivator activity /// regulation of transcription, DNA- protein binding /// sequence-specific dependent /// transcription from DNA binding /// DNA binding /// nucleus /// transcription factor 205935_at -7.48 8.324E-06 FOXF1 forkhead box F1 RNA polymerase II promoter transcription factor activity complex /// nucleus --- family with sequence similarity regulation of cell growth /// 209074_s_at -6.683 2.316E-05 FAM107A 107, member A regulation of cell growth --- nucleus /// nucleus ---

rhodopsin-like receptor activity /// Ovarian_Infertility_Gen receptor activity /// prostaglandin E es /// signal transduction /// G-protein receptor activity /// thromboxane Prostaglandin_synthesis coupled receptor protein receptor activity /// signal transducer _regulation /// signaling pathway /// G-protein activity /// G-protein coupled GPCRDB_Class_A_Rho prostaglandin E receptor 2 coupled receptor protein receptor activity /// prostaglandin E integral to plasma membrane /// dopsin-like /// 206631_at -7.375 9.706E-06 PTGER2 (subtype EP2), 53kDa signaling pathway receptor activity membrane /// integral to membrane Small_ligand_GPCRs Glycolysis / Gluconeogenesis /// Ascorbate and aldarate metabolism /// Fatty acid metabolism /// Bile acid biosynthesis /// Valine, leucine and isoleucine degradation /// Lysine degradation /// Arginine and proline metabolism /// Histidine metabolism /// Tryptophan metabolism /// beta- Alanine metabolism /// Glycerolipid metabolism /// Pyruvate metabolism /// 1,2-Dichloroethane retinal dehydrogenase activity /// 3- degradation /// chloroallyl aldehyde dehydrogenase Propanoate metabolism activity /// electron carrier activity /// /// Butanoate metabolism aldehyde dehydrogenase 1 vitamin A metabolism /// oxidoreductase activity /// catalytic /// Limonene and pinene 207016_s_at -5.538 1.137E-04 ALDH1A2 family, member A2 metabolism activity --- degradation cysteine and glycine-rich zinc ion binding /// zinc ion binding 200621_at -5.079 2.308E-04 CSRP1 protein 1 --- /// metal ion binding nucleus --- ureteric bud development /// chemotaxis /// G-protein coupled receptor protein signaling pathway /// nervous system development /// mesoderm migration /// sensory perception of smell /// neuron recognition /// motor axon guidance /// glial cell migration /// cell differentiation /// positive regulation of axonogenesis /// induction of negative chemotaxis /// induction follicle stimulating hormone of negative chemotaxis /// receptor activity /// receptor binding development /// nervous system /// calcium ion binding /// protein extracellular region /// extracellular 209897_s_at -5.234 1.772E-04 SLIT2 slit homolog 2 (Drosophila) development /// axon guidance binding space /// integral to membrane ---

protein serine/threonine kinase activity /// kinase activity /// transferase activity /// identical protein binding /// unfolded protein protein folding /// response to binding /// protein binding /// protein 221667_s_at -5.702 9.062E-05 HSPB8 heat shock 22kDa protein 8 unfolded protein serine/threonine kinase activity ------

Glucocorticoid_Mineral ocorticoid_Metabolism /// 11-beta-hydroxysteroid Prostaglandin_synthesis dehydrogenase activity /// endoplasmic reticulum /// _regulation /// C21- lipid metabolism /// metabolism oxidoreductase activity /// 11-beta- endoplasmic reticulum membrane Steroid hormone hydroxysteroid (11-beta) /// glucocorticoid metabolism /// hydroxysteroid dehydrogenase /// microsome /// membrane /// metabolism /// Androgen 205404_at -6.129 4.761E-05 HSD11B1 dehydrogenase 1 steroid metabolism activity integral to membrane and estrogen metabolism negative regulation of adenylate cyclase activity /// G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) /// nervous system development /// sensory rhodopsin-like receptor activity /// perception of sound /// signal receptor activity /// endothelin Prostaglandin_synthesis transduction /// G-protein coupled receptor activity /// signal transducer _regulation /// receptor protein signaling activity /// G-protein coupled plasma membrane /// integral to GPCRDB_Class_A_Rho pathway /// cell surface receptor receptor activity /// endothelin plasma membrane /// membrane /// dopsin-like /// 204271_s_at -5.93 6.047E-05 EDNRB endothelin receptor type B linked signal transduction receptor activity integral to membrane Peptide_GPCRs microtubule-associated protein structural molecule activity /// microtubule /// microtubule 214577_at -6.439 3.219E-05 MAP1B 1B --- protein binding associated complex ---

regulation of progression through cell cycle /// signal transduction /// cell-cell signaling /// cell proliferation /// positive regulation of cell proliferation /// fibroblast growth factor 7 epidermis development /// growth factor activity /// growth 205782_at -6.618 2.517E-05 FGF7 (keratinocyte growth factor) response to wounding factor activity extracellular region ---

transcription factor activity /// zinc ion binding /// transcriptional regulation of transcription, DNA- repressor activity /// phosphatase dependent /// nervous system regulator activity /// sequence- development /// negative specific DNA binding /// SMAD TGF_Beta_Signaling_Pa regulation of transcription /// binding /// metal ion binding /// thway /// transcription /// regulation of nucleic acid binding /// DNA TGF_Beta_Signaling_Pa 203603_s_at -5.208 1.850E-04 ZFHX1B zinc finger homeobox 1b transcription binding intracellular /// nucleus /// nucleus thway

lipid metabolism /// apoptosis /// complement activation, classical pathway /// cell death /// innate immune response /// immune response /// complement 208792_s_at -7.511 8.324E-06 CLU clusterin activation --- extracellular space --- Calcium signaling pathway /// Cytokine- cytokine receptor interaction /// Apoptosis /// Dorso-ventral axis formation /// Axon guidance /// VEGF signaling pathway /// Focal adhesion /// Adherens junction /// Gap junction /// Hematopoietic cell lineage /// Long-term depression /// Regulation of actin cytoskeleton /// Insulin signaling nucleotide binding /// protein- pathway /// GnRH tyrosine kinase activity /// signaling pathway /// transmembrane receptor protein Type II diabetes mellitus protein amino acid tyrosine kinase activity /// receptor /// phosphorylation /// cell adhesion activity /// ATP binding /// Dentatorubropallidoluysi /// cell adhesion /// signal transferase activity /// protein kinase an atrophy (DRPLA) /// transduction /// transmembrane activity /// transmembrane receptor Epithelial cell signaling discoidin domain receptor receptor protein tyrosine kinase protein tyrosine kinase activity /// integral to plasma membrane /// in Helicobacter pylori /// 205168_at -6.17 4.441E-05 DDR2 family, member 2 signaling pathway kinase activity membrane /// integral to membrane Colorectal cancer

nucleotide binding /// RNA binding RNA binding protein with /// protein binding /// nucleic acid 209487_at -5.501 1.202E-04 RBPMS multiple splicing RNA processing binding /// RNA binding ------guanylate binding protein 2, interferon-inducible /// nucleotide binding /// GTPase guanylate binding protein 2, immune response /// immune activity /// GTP binding /// GTP 202748_at -5.11 2.217E-04 GBP2 interferon-inducible response binding membrane ---

transmembrane receptor activity /// extracellular matrix structural EGF-containing fibulin-like homophilic cell adhesion /// blood constituent /// calcium ion binding /// 206580_s_at -5.36 1.492E-04 EFEMP2 extracellular matrix protein 2 coagulation protein binding basement membrane /// membrane --- loss of heterozygosity, 11, cell cycle /// negative regulation 205011_at -5.38 1.454E-04 LOH11CR2A chromosomal region 2, gene A of progression through cell cycle ------complement activation, alternative pathway /// innate immune response /// immune response /// complement 213800_at -5.7 9.062E-05 CFH complement factor H activation --- extracellular space ---

phosphate transport /// cell adhesion /// visual perception /// structural molecule activity /// negative regulation of cell extracellular matrix structural collagen /// cytoplasm /// proliferation /// organ constituent /// protein binding /// zinc extracellular matrix /// extracellular 209082_s_at -5.288 1.636E-04 COL18A1 collagen, type XVIII, alpha 1 morphogenesis ion binding /// metal ion binding matrix (sensu Metazoa) ---

carbohydrate metabolism /// N- N-acetylglucosamine 6-O- carbohydrate (N- acetylglucosamine metabolism /// sulfotransferase activity /// Golgi trans face /// membrane /// acetylglucosamine-6-O) sulfur metabolism /// transferase activity /// integral to membrane /// intrinsic to 203921_at -5.157 2.021E-04 CHST2 sulfotransferase 2 inflammatory response sulfotransferase activity Golgi membrane ---

protein amino acid nucleotide binding /// G-protein phosphorylation /// signal coupled receptor kinase activity /// transduction /// G-protein signal transducer activity /// protein signaling, coupled to cAMP kinase C binding /// ATP binding /// nucleotide second messenger /// phospholipid binding /// transferase Calcium_regulation_in_ regulation of G-protein coupled activity /// protein kinase activity /// cardiac_cells /// G protein-coupled receptor receptor protein signaling protein serine/threonine kinase Smooth_muscle_contrac 204396_s_at -6.511 2.957E-05 GRK5 kinase 5 pathway activity /// kinase activity soluble fraction /// cytoplasm tion

cell motility /// cell adhesion /// actin binding /// structural molecule intercellular junction /// adherens lamellipodium biogenesis /// activity /// oxidoreductase activity /// junction /// focal adhesion /// actin negative regulation of cell alpha-catenin binding /// protein cytoskeleton /// cell-matrix junction Integrin- migration /// apical junction binding /// protein binding /// actin /// costamere /// protein complex /// mediated_cell_adhesion 200931_s_at -5.051 2.374E-04 VCL vinculin assembly /// cell adhesion binding /// protein binding cytoskeleton /// cytoskeleton _KEGG cell motility /// cell surface receptor linked signal transduction /// nervous system development /// actin cytoskeleton organization and biogenesis /// positive regulation of I-kappaB kinase/NF-kappaB actin binding /// signal transducer cascade /// positive regulation of I-activity /// protein binding /// actin filamin A, alpha (actin binding kappaB kinase/NF-kappaB filament binding /// signal transducer 213746_s_at -6.79 2.065E-05 FLNA protein 280) cascade activity actin cytoskeleton /// cytoskeleton ---

nucleotide binding /// magnesium ion binding /// calcium-transporting ATPase activity /// calcium ion binding /// calmodulin binding /// ATP binding /// hydrolase activity /// hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances /// chaperone binding /// cation transport /// calcium ion protein binding /// unfolded protein transport /// metabolism /// protein binding /// catalytic activity /// folding /// cellular protein calcium-transporting ATPase metabolism /// transport /// ion activity /// calcium ion transporter transport /// regulation of activity /// ATPase activity, coupled plasma membrane /// integral to apoptosis /// transport /// protein to transmembrane movement of plasma membrane /// mitochondrion folding /// response to unfolded ions, phosphorylative mechanism /// /// membrane /// integral to ATPase, Ca++ transporting, protein /// protein import into metal ion binding /// unfolded membrane /// cytoplasm /// Calcium signaling 212136_at -6.807 2.065E-05 ATP2B4 plasma membrane 4 mitochondrial matrix protein binding /// ATP binding mitochondrion pathway

cytoskeleton organization and nucleus /// cytoplasm /// plasma biogenesis /// striated muscle calcium ion binding /// actin filament membrane /// actin cytoskeleton /// development /// barbed-end actin binding /// actin binding /// costamere /// cytoskeleton /// 202565_s_at -6.898 1.797E-05 SVIL supervillin filament capping /// transport transporter activity membrane /// integral to membrane --- actin binding /// structural smooth muscle contraction /// constituent of muscle /// structural 207390_s_at -5.184 1.924E-04 SMTN smoothelin muscle development molecule activity actin cytoskeleton /// cytoskeleton --- protein binding /// zinc ion binding PDZ and LIM domain 7 ossification /// cell differentiation /// metal ion binding /// protein 203370_s_at -6.02 5.612E-05 PDLIM7 (enigma) /// development binding cytoskeleton --- embryonal Fyn-associated cell adhesion /// intracellular 204400_at -7.093 1.412E-05 EFS substrate signaling cascade protein binding cytoplasm ---

actin binding /// structural constituent of muscle /// structural cytoskeleton /// muscle thin filament Striated_muscle_contrac 204083_s_at -6.067 5.213E-05 TPM2 tropomyosin 2 (beta) --- constituent of cytoskeleton tropomyosin tion

angiogenesis /// response to hypoxia /// regulation of RNA polymerase II transcription transcription, DNA-dependent /// factor activity, enhancer binding /// transcription from RNA transcription coactivator activity /// polymerase II promoter /// signal signal transducer activity /// protein transduction /// cell differentiation binding /// histone acetyltransferase /// transcription /// signal binding /// DNA binding /// endothelial PAS domain protein transduction /// development /// transcription factor activity /// 200878_at -5.269 1.681E-04 EPAS1 1 regulation of transcription transcription regulator activity nucleus ---

pregnancy /// antigen presentation /// immune response /// antigen presentation, endogenous antigen /// antigen processing, receptor activity /// IgG binding /// Fc fragment of IgG, receptor, endogenous antigen via MHC MHC class I receptor activity /// membrane /// integral to membrane 218831_s_at -5.198 1.884E-04 FCGRT transporter, alpha class I /// immune response receptor activity /// MHC class I protein complex --- transforming, acidic coiled-coil 200911_s_at -6.232 4.242E-05 TACC1 containing protein 1 cell cycle /// cell division protein binding nucleus --- Glycolysis / Gluconeogenesis /// Ascorbate and aldarate metabolism /// Fatty acid metabolism /// Bile acid biosynthesis /// Valine, leucine and isoleucine degradation /// Lysine degradation /// Arginine and proline metabolism /// Histidine metabolism /// Tryptophan metabolism /// beta- Alanine metabolism /// Glycerolipid metabolism /// Pyruvate metabolism aldehyde dehydrogenase (NAD) /// 1,2-Dichloroethane activity /// aldehyde dehydrogenase degradation /// [NAD(P)+] activity /// electron Propanoate metabolism carbohydrate metabolism /// carrier activity /// aldehyde /// Butanoate metabolism aldehyde dehydrogenase 2 alcohol metabolism /// dehydrogenase (NAD) activity /// /// Limonene and pinene 201425_at -6.214 4.242E-05 ALDH2 family (mitochondrial) metabolism oxidoreductase activity mitochondrion degradation DNA binding /// zinc ion binding /// 213698_at -5.51 1.187E-04 ZMYM6 zinc finger, MYM-type 6 development metal ion binding nucleus ---

transcription /// regulation of transcription from RNA polymerase II promoter /// intracellular signaling cascade /// transcription factor activity /// signal JAK-STAT cascade /// regulation transducer activity /// calcium ion signal transducer and activator of transcription, DNA-dependent binding /// DNA binding /// 205026_at -5.131 2.121E-04 STAT5B of transcription 5B /// signal transduction transcription factor activity nucleus --- immune response /// cell adhesion /// cytokine and chemokine mediated signaling pathway /// immune cell chemotaxis /// positive regulation of inflammatory response /// leukocyte adhesive activation /// extracellular region /// extracellular positive regulation of calcium- chemokine activity /// protein space /// cell surface /// membrane independent cell-cell adhesion /// binding /// cytokine activity /// /// integral to membrane /// chemokine (C-X3-C motif) immune response /// defense protein binding /// chemokine extracellular region /// integral to 823_at -7.509 8.324E-06 CX3CL1 ligand 1 response activity /// receptor binding membrane ---

serine-type endopeptidase inhibitor activity /// endopeptidase inhibitor WAP four-disulfide core activity /// endopeptidase inhibitor 203892_at -6.393 3.469E-05 WFDC2 domain 2 proteolysis /// spermatogenesis activity extracellular space --- LIM and cysteine-rich domains zinc ion binding /// metal ion 218574_s_at -5.961 5.829E-05 LMCD1 1 --- binding ------

transport /// muscle contraction /// cell-cell signaling /// heart development /// sensory perception of sound /// gap junction assembly /// positive signal transducer activity /// protein integral to plasma membrane /// Calcium_regulation_in_ regulation of I-kappaB kinase/NF- binding /// ion transporter activity /// connexon complex /// membrane /// cardiac_cells /// gap junction protein, alpha 1, kappaB cascade /// cell connexon channel activity /// gap junction /// connexon complex Smooth_muscle_contrac 201667_at -5.173 1.969E-04 GJA1 43kDa (connexin 43) communication connexon channel activity /// integral to membrane tion

cell adhesion /// integrin-mediated ruffle /// integrin complex /// Integrin- integrin, alpha 5 (fibronectin signaling pathway /// cell receptor activity /// calcium ion membrane /// integral to membrane mediated_cell_adhesion 201389_at -5.098 2.256E-04 ITGA5 receptor, alpha polypeptide) adhesion binding /// protein binding /// integrin complex _KEGG

transcription /// regulation of transcription, DNA-dependent /// signal transduction /// circadian Circadian_Exercise /// 205251_at -5.487 1.220E-04 PER2 period homolog 2 (Drosophila) rhythm /// rhythmic process signal transducer activity nucleus Circadian_Exercise iron ion binding /// steroid hydroxylase activity /// heme binding /// metal ion binding /// cholestanetriol 26-monooxygenase cytochrome P450, family 27, activity /// monooxygenase activity mitochondrion /// membrane /// Bile acid biosynthesis /// 203979_at -6.546 2.777E-05 CYP27A1 subfamily A, polypeptide 1 electron transport /// oxidoreductase activity mitochondrion PPAR signaling pathway protein folding /// response to unfolded protein /// response to heat shock protein binding /// DnaJ (Hsp40) homolog, heat /// response to unfolded unfolded protein binding /// unfolded 203810_at -5.554 1.108E-04 DNAJB4 subfamily B, member 4 protein protein binding /// protein binding ------

nucleotide binding /// protein serine/threonine kinase activity /// structural molecule activity /// ATP cytokinesis /// protein amino acid binding /// zinc ion binding /// phosphorylation /// muscle transferase activity /// diacylglycerol contraction /// intracellular binding /// metal ion binding /// G13_Signaling_Pathway signaling cascade /// protein protein kinase activity /// protein /// Integrin- Rho-associated, coiled-coil amino acid phosphorylation /// serine/threonine kinase activity /// mediated_cell_adhesion 202762_at -5.083 2.308E-04 ROCK2 containing protein kinase 2 signal transduction kinase activity intracellular /// actin cytoskeleton _KEGG

polypyrimidine tract binding nuclear mRNA splicing, via nucleotide binding /// RNA binding mRNA_processing_Rea 218683_at -5.9 6.275E-05 PTBP2 protein 2 spliceosome /// mRNA processing /// nucleic acid binding nucleus ctome

PC4 and SFRS1 interacting transcription /// regulation of 209337_at -5.176 1.960E-04 PSIP1 protein 1 transcription, DNA-dependent DNA binding nucleus ---

regulation of progression through cell cycle /// activation of MAPK activity /// angiogenesis /// chemotaxis /// signal transduction /// Ras protein signal transduction /// cell-cell signaling /// nervous system development /// muscle development /// cell proliferation /// positive regulation of cell proliferation /// organ fibroblast growth factor 2 morphogenesis /// cell protein binding /// growth factor extracellular region /// extracellular 204422_s_at -6.546 2.777E-05 FGF2 (basic) differentiation /// development activity /// heparin binding space --- regulation of progression through cell cycle /// cell cycle /// mitosis protein C-terminus binding /// /// cell proliferation /// negative microtubule plus-end binding /// microtubule-associated protein, regulation of microtubule protein binding /// microtubule spindle /// microtubule /// cortical 200713_s_at -6.106 4.934E-05 MAPRE1 RP/EB family, member 1 polymerization /// cell division binding microtubule cytoskeleton ---

catalytic activity /// 3',5'-cyclic- nucleotide phosphodiesterase activity /// cGMP-stimulated cyclic- phosphodiesterase 2A, cGMP- nucleotide phosphodiesterase 204134_at -5.5 1.204E-04 PDE2A stimulated signal transduction activity /// hydrolase activity membrane ---

DNA replication /// transcription /// regulation of transcription, DNA-dependent /// development retinoblastoma binding protein /// cell proliferation /// chromatin 201092_at -5.639 9.755E-05 RBBP7 7 modification protein binding nucleus ---

cell cycle /// cell proliferation /// regulation of endocytosis /// cell differentiation /// negative regulation of progression through nucleus /// cytoplasm /// actin cell cycle /// endocytosis /// protein binding /// hydrogen ion cytoskeleton /// mitochondrion /// development /// ATP biosynthesis transporter activity /// hydrolase membrane /// proton-transporting /// transport /// ion transport /// activity /// metal ion binding /// two-sector ATPase complex /// ATP synthesis coupled proton hydrogen-transporting ATP synthase proton-transporting ATP synthase transport /// proton transport /// activity, rotational mechanism /// complex, catalytic core F(1) /// Electron_Transport_Cha regulation of progression through hydrogen-transporting ATPase proton-transporting ATP synthase in /// cell cycle /// generation of activity, rotational mechanism /// complex (sensu Eukaryota) /// Electron_Transport_Cha 210202_s_at -5.104 2.240E-04 BIN1 bridging integrator 1 precursor metabolites and energy transporter activity membrane fraction in protein binding /// identical protein 38157_at 5.348 1.505E-04 DOM3Z dom-3 homolog Z (C. elegans) --- binding ------Synthesis_and_Degradat ion_of_Keton_Bodies_K EGG /// Synthesis_and_Degradat ion_of_Keton_Bodies_K EGG /// Fatty acid metabolism /// Synthesis and degradation of ketone bodies /// Valine, leucine and isoleucine degradation /// Lysine degradation /// Tryptophan metabolism /// Pyruvate metabolism /// Benzoate degradation via CoA ligation /// acetyl-CoA C-acetyltransferase Propanoate metabolism acetyl-Coenzyme A activity /// acyltransferase activity /// /// Butanoate metabolism acetyltransferase 1 (acetoacetyl transferase activity /// acetyl-CoA C- /// Two-component 205412_at 5.849 6.877E-05 ACAT1 Coenzyme A thiolase) --- acetyltransferase activity mitochondrion /// mitochondrion system - General

triggering receptor expressed 219725_at 5.028 2.467E-04 TREM2 on myeloid cells 2 humoral immune response receptor activity /// receptor activity membrane /// integral to membrane --- lipid metabolism /// lipid transport /// lipoprotein metabolism /// Statin_Pathway_Pharm 213553_x_at 5.208 1.850E-04 APOC1 apolipoprotein C-I transport lipid transporter activity extracellular region GKB

adenine phosphoribosyltransferase activity /// AMP binding /// transferase activity, transferring purine ribonucleoside salvage /// glycosyl groups /// adenine adenine adenine salvage /// nucleoside phosphoribosyltransferase activity /// 213892_s_at 5.235 1.772E-04 APRT phosphoribosyltransferase metabolism transferase activity cytoplasm Purine metabolism response to stress /// cell cycle /// cell growth regulator with EF- cell cycle arrest /// negative calcium ion binding /// kinase 205937_at 5.146 2.063E-04 CGREF1 hand domain 1 regulation of cell proliferation activity ------

folic acid binding /// folic acid transporter activity /// reduced folate carrier activity /// methotrexate membrane fraction /// integral to solute carrier family 19 (folate transporter activity /// nutrient plasma membrane /// membrane /// 211576_s_at 7.458 8.362E-06 SLC19A1 transporter), member 1 transport /// folic acid transport reservoir activity integral to membrane ---

electron transport /// proline pyrroline-5-carboxylate reductase Urea cycle and biosynthesis /// proline activity /// pyrroline-5-carboxylate metabolism of amino pyrroline-5-carboxylate biosynthesis /// amino acid reductase activity /// oxidoreductase groups /// Arginine and 202148_s_at 8.161 4.812E-06 PYCR1 reductase 1 biosynthesis activity --- proline metabolism

protein biosynthesis /// positive regulation of cell proliferation /// hypusine biosynthesis from peptidyl-lysine /// spermidine catabolism to deoxyhypusine, using deoxyhypusine synthase /// spermidine catabolism to deoxyhypusine, using 211558_s_at 6.036 5.529E-05 DHPS deoxyhypusine synthase deoxyhypusine synthase transferase activity ------

response to stress /// response to external stimulus /// negative regulation of translational nucleotide binding /// eukaryotic initiation by iron /// protein amino translation initiation factor 2alpha acid autophosphorylation /// kinase activity /// ATP binding /// negative regulation of transferase activity /// heme binding hemoglobin biosynthesis /// /// protein homodimerization activity protein biosynthesis /// protein /// protein kinase activity /// protein amino acid phosphorylation /// serine/threonine kinase activity /// eukaryotic translation initiation negative regulation of protein kinase activity /// damaged DNA 217736_s_at 6.922 1.797E-05 EIF2AK1 factor 2-alpha kinase 1 biosynthesis binding --- Translation_Factors thioredoxin peroxidase activity /// oxidoreductase activity /// peroxiredoxin activity /// peroxidase 201923_at 7.957 5.782E-06 PRDX4 peroxiredoxin 4 I-kappaB phosphorylation activity /// antioxidant activity ------

protein targeting /// vesicle targeting /// transport /// adaptor-related protein complex intracellular protein transport /// 65517_at 6.457 3.219E-05 AP1M2 1, mu 2 subunit protein transport --- coated pit /// clathrin vesicle coat ---

aminoacylase activity /// metallopeptidase activity /// zinc ion proteolysis /// amino acid binding /// hydrolase activity /// Urea cycle and metabolism /// amino acid protein dimerization activity /// metabolism of amino 202740_at 5.371 1.471E-04 ACY1 aminoacylase 1 metabolism aminoacylase activity cytoplasm /// cytosol groups

staphylococcal nuclease domain transcription /// regulation of nucleic acid binding /// transcription 201622_at 5.505 1.202E-04 SND1 containing 1 transcription, DNA-dependent cofactor activity /// nuclease activity nucleus /// nucleus ---

carbohydrate metabolism /// Pentose_Phosphate_Path pentose-phosphate shunt /// hydrolase activity /// 6- way /// Pentose 218387_s_at 5.95 5.829E-05 PGLS 6-phosphogluconolactonase pentose-phosphate shunt phosphogluconolactonase activity --- phosphate pathway 220587_s_at 5.515 1.181E-04 GBL G protein beta subunit-like ------solute carrier family 25 (mitochondrial carrier; gluconeogenesis /// transport /// dicarboxylate transporter), dicarboxylic acid transport /// dicarboxylic acid transporter activity mitochondrion /// membrane /// 218275_at 6.713 2.237E-05 SLC25A10 member 10 mitochondrial transport /// binding integral to membrane --- general transcription factor IIIC, polypeptide 2, beta transcription /// transcription from RNA polymerase III transcription transcription factor TFIIIC complex 212429_s_at 5.751 8.288E-05 GTF3C2 110kDa RNA polymerase III promoter factor activity /// protein binding /// nucleus ---

protein folding /// response to unfolded protein /// protein nucleotide binding /// protein import into mitochondrial matrix binding /// ATP binding /// ATP /// regulation of apoptosis /// binding /// unfolded protein binding heat shock 60kDa protein 1 cellular protein metabolism /// /// chaperone binding /// unfolded cytoplasm /// mitochondrion /// 200807_s_at 5.924 6.104E-05 HSPD1 (chaperonin) protein folding protein binding mitochondrion --- Huntingtin interacting protein 218680_x_at 5.624 9.940E-05 HYPK K --- protein binding ------Glycolysis_and_Glucon eogenesis /// Krebs- TCA_Cycle /// Citrate cycle (TCA cycle) /// Pyruvate metabolism /// Glyoxylate and L-lactate dehydrogenase activity /// dicarboxylate glycolysis /// tricarboxylic acid oxidoreductase activity /// L-malate metabolism /// Carbon cycle /// malate metabolism /// dehydrogenase activity /// malate fixation /// Reductive malate dehydrogenase 2, NAD tricarboxylic acid cycle dehydrogenase activity /// L-malate mitochondrion /// mitochondrial carboxylate cycle (CO2 209036_s_at 5.054 2.372E-04 MDH2 (mitochondrial) intermediate metabolism dehydrogenase activity matrix fixation) Electron_Transport_Cha in /// cytochrome-c oxidase activity /// Electron_Transport_Cha iron ion binding /// electron carrier in /// Oxidative activity /// metal ion binding /// phosphorylation /// cytochrome c oxidase subunit cytochrome-c oxidase activity /// VEGF signaling 203663_s_at 6.01 5.652E-05 COX5A Va electron transport oxidoreductase activity mitochondrion /// membrane pathway

translation initiation factor activity eukaryotic translation initiation protein biosynthesis /// regulation /// protein binding /// translation eukaryotic translation initiation Translation_Factors /// 208756_at 6.947 1.797E-05 EIF3S2 factor 3, subunit 2 beta, 36kDa of translational initiation factor activity, nucleic acid binding factor 3 complex Translation_Factors

magnesium ion binding /// inorganic diphosphatase activity /// hydrolase pyrophosphatase (inorganic) 2 activity /// protein binding /// zinc Oxidative 220741_s_at 5.032 2.458E-04 PPA2 /// RNF36 /// ring finger protein 36 phosphate metabolism ion binding /// metal ion binding cytoplasm /// mitochondrion phosphorylation

NADH dehydrogenase activity /// NADH dehydrogenase (ubiquinone) NADH dehydrogenase activity /// oxidoreductase activity /// membrane fraction /// (ubiquinone) 1 alpha ATP synthesis coupled electron NADH dehydrogenase (ubiquinone) mitochondrion /// mitochondrial Electron_Transport_Cha 202785_at 5.389 1.436E-04 NDUFA7 subcomplex, 7, 14.5kDa transport activity inner membrane in

nuclear mRNA splicing, via spliceosome /// mRNA splice site splicing factor, arginine/serine- selection /// mRNA processing /// nucleotide binding /// RNA binding mRNA_processing_Rea 201698_s_at 5.229 1.779E-04 SFRS9 rich 9 mRNA processing /// nucleic acid binding nucleus /// nucleus ctome nuclear mRNA splicing, via splicing factor, arginine/serine- spliceosome /// mRNA splice site rich 9 /// splicing factor, selection /// mRNA processing /// nucleotide binding /// RNA binding mRNA_processing_Rea 200044_at 5.097 2.256E-04 SFRS9 arginine/serine-rich 9 mRNA processing /// nucleic acid binding nucleus /// nucleus ctome

Ribosomal_Proteins /// protein biosynthesis /// ribosome intracellular /// ribosome /// Ribosomal_Proteins /// 217740_x_at 6.202 4.269E-05 RPL7A ribosomal protein L7a biogenesis and assembly structural constituent of ribosome ribonucleoprotein complex Ribosomal_Proteins intracellular /// ribosome /// cytosolic large ribosomal subunit RNA binding /// structural (sensu Eukaryota) /// constituent of ribosome /// RNA ribonucleoprotein complex /// protein biosynthesis /// phosphate binding /// structural constituent of cytoplasm /// extracellular matrix 200809_x_at 5.446 1.311E-04 RPL12 ribosomal protein L12 transport ribosome (sensu Metazoa) Ribosomal_Proteins

Electron_Transport_Cha in /// Electron_Transport_Cha in /// Oxidative membrane fraction /// phosphorylation /// ATP mitochondrion /// proton- synthesis /// transporter activity /// lipid binding transporting ATP synthase complex Photosynthesis /// /// hydrogen-transporting ATP (sensu Eukaryota) /// membrane /// Flagellar assembly /// synthase activity, rotational proton-transporting two-sector Type III secretion mechanism /// hydrogen-transporting ATPase complex /// proton- system /// Epithelial cell ATP synthase, H+ transporting, ion transport /// ATP synthesis ATPase activity, rotational transporting ATP synthase signaling in Helicobacter mitochondrial F0 complex, coupled proton transport /// mechanism /// hydrogen ion complex, coupling factor F(o) /// pylori /// Purine 208764_s_at 5.098 2.256E-04 ATP5G2 subunit C2 (subunit 9) proton transport /// transport transporter activity integral to membrane metabolism integral to plasma membrane /// 202857_at 5.952 5.829E-05 TMEM4 transmembrane protein 4 --- protein binding endoplasmic reticulum --- cytochrome-c oxidase activity /// cytochrome c oxidase subunit electron carrier activity /// mitochondrion /// mitochondrial Electron_Transport_Cha 201256_at 5.36 1.492E-04 COX7A2L VIIa polypeptide 2 like electron transport cytochrome-c oxidase activity electron transport chain in

intracellular /// cytosolic small ribosomal subunit (sensu structural constituent of ribosome /// Eukaryota) /// ribosome /// small Ribosomal_Proteins /// protein biosynthesis /// protein protein binding /// structural ribosomal subunit /// Ribosomal_Proteins /// biosynthesis /// metal ion constituent of ribosome /// metal ion ribonucleoprotein complex /// Ribosomal_Proteins /// 200819_s_at 5.158 2.021E-04 RPS15 ribosomal protein S15 transport transporter activity membrane Ribosomal_Proteins Electron_Transport_Cha in /// NADH dehydrogenase Electron_Transport_Cha (ubiquinone) 1 beta NADH dehydrogenase activity /// in /// Oxidative subcomplex, 4, 15kDa /// NADH dehydrogenase (ubiquinone) phosphorylation /// similar to NADH electron transport /// activity /// NADH dehydrogenase Ubiquinone biosynthesis NDUFB4 /// dehydrogenase (ubiquinone) 1 mitochondrial electron transport, (ubiquinone) activity /// membrane fraction /// /// Oxidative 218226_s_at 5.272 1.679E-04 LOC653432 beta subcomplex, 4, 15kDa NADH to ubiquinone oxidoreductase activity mitochondrion phosphorylation acyl-CoA binding /// dodecenoyl- CoA delta-isomerase activity /// peroxisomal D3,D2-enoyl-CoA fatty acid metabolism /// isomerase activity /// catalytic 218025_s_at 5.051 2.374E-04 PECI isomerase metabolism activity peroxisome /// peroxisome ---

Valine, leucine and propionyl-CoA carboxylase activity isoleucine degradation propionyl Coenzyme A /// ligase activity /// propionyl-CoA /// Propanoate 212694_s_at 6.72 2.237E-05 PCCB carboxylase, beta polypeptide fatty acid catabolism carboxylase activity mitochondrion /// mitochondrion metabolism alpha-methylacyl-CoA racemase activity /// lyase activity /// mitochondrion /// peroxisome /// alpha-methylacyl-CoA metabolism /// phosphate isomerase activity /// catalytic cytoplasm /// mitochondrion /// 209426_s_at 8.374 3.758E-06 AMACR racemase transport activity peroxisome ---

regulation of transcription, DNA- dependent /// regulation of transcription from RNA polymerase II promoter /// transcription factor activity /// development /// transcription /// transcription corepressor activity /// development /// regulation of sequence-specific DNA binding /// transcription /// regulation of DNA binding /// transcriptional transcription, DNA-dependent /// activator activity /// transcription 206858_s_at 7.226 1.180E-05 HOXC6 homeobox C6 development factor activity nucleus /// nucleus ---

NADH dehydrogenase activity /// iron ion binding /// NADH dehydrogenase (ubiquinone) activity /// metal ion binding /// 2 iron, 2 Electron_Transport_Cha mitochondrial electron transport, sulfur cluster binding /// NADH in /// Oxidative NADH to ubiquinone /// nervous dehydrogenase (ubiquinone) activity phosphorylation /// NADH dehydrogenase system development /// /// oxidoreductase activity /// iron- Ubiquinone biosynthesis (ubiquinone) flavoprotein 2, mitochondrial electron transport, sulfur cluster binding /// electron membrane fraction /// /// Oxidative 202941_at 5.571 1.088E-04 NDUFV2 24kDa NADH to ubiquinone carrier activity mitochondrion phosphorylation serine-type endopeptidase inhibitor activity /// serine-type endopeptidase serpin peptidase inhibitor, clade inhibitor activity /// protein binding 211474_s_at 5.443 1.315E-04 SERPINB6 B (ovalbumin), member 6 --- /// endopeptidase inhibitor activity cytosol ---

Fatty acid elongation in mitochondria /// Fatty acid metabolism /// Valine, leucine and isoleucine degradation /// Lysine degradation /// Tryptophan metabolism /// beta-Alanine metabolism /// Benzoate degradation via CoA ligation /// Propanoate metabolism /// Butanoate generation of precursor metabolism /// Limonene metabolites and energy /// lipid and pinene degradation metabolism /// fatty acid enoyl-CoA hydratase activity /// /// Caprolactam enoyl Coenzyme A hydratase, metabolism /// fatty acid beta- lyase activity /// catalytic activity /// degradation /// PPAR 201135_at 5.264 1.692E-04 ECHS1 short chain, 1, mitochondrial oxidation /// metabolism enoyl-CoA hydratase activity mitochondrion /// mitochondrion signaling pathway DNA binding /// zinc ion binding /// intracellular /// nucleus /// nuclear metal ion binding /// nucleic acid origin of replication recognition 219041_s_at 5.289 1.636E-04 REPIN1 replication initiator 1 DNA replication binding complex ---

Oxidative hydrolase activity /// metal ion phosphorylation /// ATP binding /// hydrogen-transporting synthesis /// ATP synthase activity, rotational Photosynthesis /// ion transport /// ATP synthesis mechanism /// hydrogen-transporting Flagellar assembly /// coupled proton transport /// ATPase activity, rotational membrane fraction /// proton- Type III secretion proton transport /// ATP mechanism /// hydrogen ion transporting two-sector ATPase system /// Epithelial cell ATPase, H+ transporting, biosynthesis /// transport /// transporter activity /// hydrogen ion complex /// proton-transporting two- signaling in Helicobacter 201527_at 5.021 2.485E-04 ATP6V1F lysosomal 14kDa, V1 subunit F proton transport transporter activity sector ATPase complex pylori guanyl-nucleotide exchange factor activity /// zinc ion binding /// metal membrane fusion /// small ion binding /// guanyl-nucleotide GTPase mediated signal exchange factor activity /// zinc ion transduction /// protein transport binding /// guanyl-nucleotide 204478_s_at 5.526 1.160E-04 RABIF RAB interacting factor /// transport exchange factor activity ------

nucleotide binding /// protein MAPKKK cascade /// calcium- serine/threonine kinase activity /// mediated signaling /// regulation calcium- and calmodulin-dependent of protein kinase activity /// protein kinase activity /// protein- positive regulation of tyrosine kinase activity /// calcium transcription /// protein amino ion binding /// calmodulin binding /// acid autophosphorylation /// ATP binding /// transferase activity protein amino acid /// protein kinase activity /// protein phosphorylation /// protein amino serine/threonine kinase activity /// calcium/calmodulin-dependent acid phosphorylation /// protein calmodulin binding /// ATP binding 213812_s_at 5.523 1.164E-04 CAMKK2 protein kinase kinase 2, beta amino acid phosphorylation /// kinase activity intracellular --- protein complex assembly /// RALBP1 associated Eps epidermal growth factor receptor calcium ion binding /// calcium ion 205645_at 5.671 9.484E-05 REPS2 domain containing 2 signaling pathway binding /// protein binding ------peptidyl-prolyl cis-trans isomerase activity /// FK506 binding /// isomerase activity /// protein FK506 binding protein 4, binding, bridging /// protein binding intracellular /// nucleus /// Calcium signaling 200895_s_at 5.402 1.397E-04 FKBP4 59kDa protein folding /// protein folding /// binding cytoplasm pathway

RNA binding /// methyltransferase activity /// mRNA (2'-O- methyladenosine-N6-)- methyltransferase activity /// RNA methylation /// nucleobase, transferase activity /// mRNA (2'-O- nucleoside, nucleotide and methyladenosine-N6-)- mRNA_processing_Rea 209265_s_at 5.686 9.278E-05 METTL3 methyltransferase like 3 nucleic acid metabolism methyltransferase activity nucleus /// nucleus ctome regulation of transcription, DNA- dependent /// signal transduction /// nervous system development transcription factor activity /// signal /// cell differentiation /// transducer activity /// DNA binding transcription /// development /// /// transcription factor activity /// single-minded homolog 2 nervous system development /// transcription regulator activity /// 206558_at 6.795 2.065E-05 SIM2 (Drosophila) regulation of transcription DNA binding nucleus --- Golgi membrane /// cytoplasm /// neurotransmitter transport /// cytosol /// membrane /// secretory regulation of neurotransmitter granule membrane /// synaptic 207949_s_at 5.292 1.636E-04 ICA1 islet cell autoantigen 1, 69kDa secretion /// transport --- vesicle membrane --- Calcium_regulation_in_ cardiac_cells /// Calcium_regulation_in_ cardiac_cells /// Smooth_muscle_contrac tion /// regulator of G-protein negative regulation of signal Smooth_muscle_contrac 204319_s_at 5.914 6.118E-05 RGS10 signalling 10 transduction signal transducer activity --- tion gap junction protein, beta 1, 32kDa (connexin 32, Charcot- transport /// cell-cell signaling /// connexon complex /// integral to Marie-Tooth neuropathy, X- nervous system development /// connexon channel activity /// membrane /// gap junction /// Calcium_regulation_in_ 204973_at 5.495 1.209E-04 GJB1 linked) cell communication connexon channel activity connexon complex cardiac_cells 200644_at 7.782 6.745E-06 MARCKSL1 MARCKS-like 1 --- calmodulin binding ------

actin binding /// protein kinase C binding /// protein binding /// zinc ion binding /// receptor signaling complex scaffold activity /// actinin 203243_s_at 5.371 1.471E-04 PDLIM5 PDZ and LIM domain 5 heart development binding /// metal ion binding membrane fraction /// cytosol ---

endosome /// integral to plasma transmembrane 9 superfamily membrane /// membrane /// integral 201078_at 5.413 1.377E-04 TM9SF2 member 2 transport /// transport transporter activity to membrane ---

induction of apoptosis /// BCL2-interacting killer apoptotic program /// regulation 205780_at 5.024 2.484E-04 BIK (apoptosis-inducing) of apoptosis /// apoptosis protein binding membrane /// integral to membrane --- transcription factor activity /// sequence-specific DNA binding /// transcription /// regulation of DNA binding /// transcription factor 204667_at 5.092 2.271E-04 FOXA1 forkhead box A1 transcription, DNA-dependent activity nucleus --- Glycolysis_and_Glucon eogenesis /// Glycolysis / fructose-2,6-bisphosphate 2- Gluconeogenesis /// phosphatase activity /// zinc ion Pentose phosphate binding /// hydrolase activity /// pathway /// Fructose and fructose-bisphosphatase activity /// mannose metabolism /// carbohydrate metabolism /// phosphoric ester hydrolase activity Carbon fixation /// fructose metabolism /// /// identical protein binding /// Insulin signaling 209696_at 7.487 8.324E-06 FBP1 fructose-1,6-bisphosphatase 1 gluconeogenesis catalytic activity --- pathway

nucleotide binding /// chloride channel activity /// ATP binding /// 15-hydroxyprostaglandin dehydrogenase (NAD+) activity /// ATPase activity /// ATPase activity, membrane fraction /// plasma ATP-binding cassette, sub- coupled to transmembrane membrane /// integral to membrane family C (CFTR/MRP), movement of substances /// /// platelet dense granule membrane 203196_at 7.148 1.310E-05 ABCC4 member 4 ion transport /// transport nucleoside-triphosphatase activity /// membrane --- tumor-associated calcium signal plasma membrane /// integral to 201839_s_at 8.533 3.175E-06 TACSTD1 transducer 1 ------membrane /// membrane --- protein modification /// protein amino acid glycosylation /// response to stress /// plasma stress-associated endoplasmic membrane organization and 200971_s_at 6.255 4.215E-05 SERP1 reticulum protein 1 biogenesis --- endoplasmic reticulum /// ribosome --- Oxidative phosphorylation /// ATP synthesis /// Photosynthesis /// Flagellar assembly /// Type III secretion ATPase, H+ transporting, hydrogen ion transporter activity /// system /// Epithelial cell lysosomal 13kDa, V1 subunit ATP biosynthesis /// ion transport hydrolase activity /// metal ion signaling in Helicobacter 208737_at 5.422 1.358E-04 ATP6V1G1 G1 /// proton transport /// transport binding --- pylori

protein disulfide isomerase activity /// electron carrier activity /// protein disulfide oxidoreductase activity /// isomerase activity /// protein protein disulfide isomerase electron transport /// protein disulfide isomerase activity /// endoplasmic reticulum /// Antigen processing and 203857_s_at 5.489 1.220E-04 PDIA5 family A, member 5 folding /// response to stress oxidoreductase activity endoplasmic reticulum lumen presentation polypeptide N- acetylgalactosaminyltransferase activity /// calcium ion binding /// UDP-N-acetyl-alpha-D- sugar binding /// transferase activity, galactosamine:polypeptide N- carbohydrate metabolism /// transferring glycosyl groups /// O-Glycan biosynthesis acetylgalactosaminyltransferase protein amino acid O-linked manganese ion binding /// /// Glycan structures - 218313_s_at 5.031 2.458E-04 GALNT7 7 (GalNAc-T7) glycosylation transferase activity membrane /// integral to membrane biosynthesis 1

protein disulfide isomerase activity /// procollagen-proline 4- dioxygenase activity /// electron carrier activity /// protein disulfide oxidoreductase activity /// isomerase extracellular region /// endoplasmic procollagen-proline, 2- activity /// unfolded protein binding reticulum /// ER-Golgi intermediate Arginine and proline oxoglutarate 4-dioxygenase protein folding /// peptidyl- /// protein disulfide isomerase compartment /// cell surface /// metabolism /// Antigen (proline 4-hydroxylase), beta proline hydroxylation to 4- activity /// procollagen-proline 4- membrane /// endoplasmic processing and 200656_s_at 6.279 4.069E-05 P4HB polypeptide hydroxy-L-proline dioxygenase activity reticulum presentation

Golgi apparatus /// integral to plasma membrane /// membrane /// 217771_at 5.488 1.220E-04 GOLPH2 golgi phosphoprotein 2 ------integral to membrane ---

aldehyde reductase activity /// Glycolysis / protein binding /// alcohol Gluconeogenesis /// aldo-keto reductase family 1, dehydrogenase (NADP+) activity /// Glycerolipid metabolism member A1 (aldehyde glucose metabolism /// aldehyde electron carrier activity /// /// Caprolactam 201900_s_at 6.004 5.675E-05 AKR1A1 reductase) metabolism oxidoreductase activity --- degradation protein binding /// zinc ion binding /// metal ion binding /// chitin 219736_at 5.163 2.003E-04 TRIM36 tripartite motif-containing 36 chitin metabolism binding intracellular /// extracellular region ---

magnesium ion binding /// calcium ectonucleoside triphosphate ion binding /// hydrolase activity /// endoplasmic reticulum /// 205757_at 5.344 1.515E-04 ENTPD5 diphosphohydrolase 5 --- nucleoside-diphosphatase activity membrane /// integral to membrane --- signal transduction /// signal RAP1 GTPase activating transduction /// signal GTPase activity /// GTPase activator membrane fraction /// cytosol /// 203911_at 6.309 3.885E-05 RAP1GAP protein transduction activity /// GTPase activator activity membrane --- 201886_at 5.471 1.252E-04 WDR23 WD repeat domain 23 ------membrane fraction /// integral to plasma membrane /// membrane /// 217979_at 5.249 1.730E-04 TSPAN13 Tetraspanin 13 ------integral to membrane ---

integral to plasma membrane /// 201079_at 6.173 4.441E-05 SYNGR2 synaptogyrin 2 ------membrane /// integral to membrane ---

transmembrane emp24 protein 208837_at 5.647 9.755E-05 TMED3 transport domain containing 3 protein transport /// transport --- membrane /// integral to membrane --- serine-type endopeptidase activity /// scavenger receptor activity /// peptidase activity /// hydrolase hepsin (transmembrane activity /// serine-type peptidase integral to plasma membrane /// 204934_s_at 9.121 1.317E-06 HPN protease, serine 1) proteolysis activity membrane /// integral to membrane ---

beta-N- acetylglucosaminylglycopeptide beta- 1,4-galactosyltransferase activity /// N-acetyllactosamine synthase activity /// galactosyltransferase N-Glycan biosynthesis activity /// transferase activity, /// Keratan sulfate UDP-Gal:betaGlcNAc beta 1,4- transferring glycosyl groups /// biosynthesis /// Glycan galactosyltransferase, manganese ion binding /// metal ion structures - biosynthesis 210243_s_at 5.567 1.089E-04 B4GALT3 polypeptide 3 carbohydrate metabolism binding /// transferase activity membrane /// integral to membrane 1 cytochrome b-561 domain 209665_at 6.114 4.871E-05 CYB561D2 containing 2 electron transport /// transport iron ion binding /// metal ion binding membrane /// integral to membrane --- structural constituent of cytoskeleton erythrocyte membrane protein /// binding /// cytoskeletal protein cytoplasm /// cytoskeleton /// 220161_s_at 5.797 7.525E-05 EPB41L4B band 4.1 like 4B --- binding cytoskeleton /// membrane --- neurotransmitter transport /// intracellular protein transport /// 209238_at 5.641 9.755E-05 STX3 syntaxin 3 transport protein transporter activity membrane /// integral to membrane --- 3-hydroxyacyl-CoA dehydrogenase activity /// estradiol 17-beta- dehydrogenase activity /// sterol carrier activity /// sterol transporter activity /// oxidoreductase activity /// lyase activity /// isomerase activity hydroxysteroid (17-beta) lipid metabolism /// fatty acid /// catalytic activity /// sterol carrier 201413_at 5.051 2.374E-04 HSD17B4 dehydrogenase 4 metabolism /// metabolism activity peroxisome /// peroxisome Steroid_Biosynthesis

regulation of transcription, DNA- transcription factor activity /// nucleus /// endoplasmic reticulum LAG1 longevity assurance dependent /// lipid biosynthesis /// sequence-specific DNA binding /// /// membrane /// integral to 222212_s_at 6.013 5.652E-05 LASS2 homolog 2 (S. cerevisiae) regulation of transcription DNA binding membrane ---

ion transport /// signal receptor activity /// ATP-gated purinergic receptor P2X, ligand- transduction /// transport /// cation channel activity /// ion integral to plasma membrane /// 204088_at 5.408 1.389E-04 P2RX4 gated ion channel, 4 transport channel activity /// ATP binding membrane /// integral to membrane --- pleckstrin homology domain containing, family B (evectins) 209504_s_at 5.063 2.351E-04 PLEKHB1 member 1 phototransduction signal transducer activity membrane /// integral to membrane ---

Pentose and glucuronate interconversions /// beta-glucuronidase activity /// cation Starch and sucrose binding /// catalytic activity /// metabolism /// hydrolase activity, hydrolyzing O- Glycosaminoglycan carbohydrate metabolism /// glycosyl compounds /// beta- degradation /// Porphyrin glycosaminoglycan catabolism /// glucuronidase activity /// hydrolase and chlorophyll carbohydrate metabolism /// activity /// hydrolase activity, acting metabolism /// Glycan 202605_at 5.14 2.072E-04 GUSB glucuronidase, beta glycosaminoglycan metabolism on glycosyl bonds lysosome /// lysosome structures - degradation

small GTPase mediated signal RAB17, member RAS transduction /// protein transport 218931_at 5.742 8.387E-05 RAB17 oncogene family /// transport nucleotide binding /// GTP binding membrane --- endoplasmic reticulum /// endoplasmic reticulum /// membrane /// integral to membrane /// integral to membrane /// cytosolic signal sequence binding /// protein small ribosomal subunit (sensu signal sequence receptor, beta cotranslational protein targeting binding /// structural constituent of Eukaryota) /// intracellular /// (translocon-associated protein to membrane /// protein ribosome /// structural constituent of ribosome /// ribonucleoprotein Ribosomal_Proteins /// 200652_at 5.063 2.351E-04 SSR2 beta) biosynthesis ribosome /// receptor activity complex Ribosomal_Proteins

subtilase activity /// subtilase activity /// calcium ion binding /// peptidase proprotein convertase proteolysis /// proteolysis /// cell- activity /// serine-type endopeptidase 207414_s_at 5.213 1.839E-04 PCSK6 subtilisin/kexin type 6 cell signaling activity /// hydrolase activity endoplasmic reticulum --- dihydrouridine synthase 1-like oxidoreductase activity /// FAD 217912_at 5.406 1.393E-04 DUS1L (S. cerevisiae) tRNA processing binding ------

protein disulfide isomerase activity /// calcium ion binding /// electron carrier activity /// protein disulfide protein disulfide isomerase oxidoreductase activity /// isomerase endoplasmic reticulum /// 208658_at 5.259 1.712E-04 PDIA4 family A, member 4 protein secretion activity endoplasmic reticulum lumen --- 203430_at 5.894 6.328E-05 HEBP2 heme binding protein 2 ------

microfilament motor activity /// nucleotide binding /// motor activity /// actin binding /// calmodulin binding /// ATP binding /// ATP striated muscle contraction /// binding /// structural constituent of sensory perception of sound /// muscle /// ATPase activity, coupled actin filament-based movement /// /// actin binding /// structural unconventional myosin /// 203216_s_at 6.241 4.242E-05 MYO6 myosin VI sensory perception of sound molecule activity /// motor activity unconventional myosin /// myosin --- metalloendopeptidase activity /// metalloexopeptidase activity /// zinc ion binding /// metal ion binding /// peptidase activity /// zinc metallopeptidase (STE24 metallopeptidase activity /// endoplasmic reticulum /// 202939_at 5.964 5.829E-05 ZMPSTE24 homolog, yeast) proteolysis /// proteolysis hydrolase activity membrane /// integral to membrane --- regulation of transcription, DNA- dependent /// small GTPase nucleotide binding /// GTPase mediated signal transduction /// activity /// transporter activity /// protein transport /// plasma ATP binding /// GTP binding /// RAB11A, member RAS membrane to endosome transport transcription factor binding /// 200863_s_at 7.612 7.551E-06 RAB11A oncogene family /// transport syntaxin binding /// protein binding intracellular /// Golgi trans face ---

DNA binding /// protein binding /// transcription /// regulation of zinc ion binding /// transcriptional transcription, DNA-dependent /// repressor activity /// metal ion regulation of transcription, DNA- binding /// nucleic acid binding /// 209494_s_at 5.964 5.829E-05 ZNF278 zinc finger protein 278 dependent DNA binding intracellular /// nucleus /// nucleus ---

nuclear mRNA splicing, via spliceosome /// DNA repair /// DNA recombination /// transcription /// regulation of transcription, DNA-dependent /// non-POU domain containing, RNA splicing /// mRNA mRNA_processing_Rea octamer-binding /// non-POU processing /// response to DNA nucleotide binding /// DNA binding ctome /// domain containing, octamer- damage stimulus /// mRNA /// RNA binding /// protein binding mRNA_processing_Rea 200057_s_at 5.387 1.440E-04 NONO binding processing /// nucleic acid binding nucleus /// nucleus ctome

Ribosomal_Proteins /// Ribosomal_Proteins /// mRNA_processing_bind intracellular /// ribosome /// ing_Reactome /// 208695_s_at 5.328 1.546E-04 RPL39 ribosomal protein L39 protein biosynthesis structural constituent of ribosome ribonucleoprotein complex Ribosomal_Proteins

catalytic activity /// 3',5'-cyclic- nucleotide phosphodiesterase activity /// cGMP-inhibited cyclic- phosphodiesterase 3B, cGMP- nucleotide phosphodiesterase 208591_s_at 5.355 1.492E-04 PDE3B inhibited signal transduction activity /// hydrolase activity membrane --- RUN and SH3 domain 206949_s_at 5.687 9.278E-05 RUSC1 containing 1 --- SH3/SH2 adaptor activity nucleus ---

nucleic acid binding /// transcription factor activity /// transcription corepressor activity /// zinc ion transcription /// regulation of binding /// metal ion binding /// 206572_x_at 7.223 1.180E-05 ZNF85 zinc finger protein 85 transcription, DNA-dependent DNA binding /// DNA binding intracellular /// nucleus /// nucleus --- 2,4-dienoyl-CoA reductase (NADPH) activity /// oxidoreductase activity /// nucleotide binding /// magnesium ion binding /// metabolism /// GTP biosynthesis nucleoside diphosphate kinase /// UTP biosynthesis /// CTP activity /// ATP binding /// kinase biosynthesis /// nucleotide activity /// transferase activity /// 2,4-dienoyl CoA reductase 2, metabolism /// nucleoside metal ion binding /// nucleoside peroxisome /// mitochondrion /// 219664_s_at 5.314 1.597E-04 DECR2 peroxisomal metabolism diphosphate kinase activity mitochondrion ---

219061_s_at 5.114 2.193E-04 LAGE3 L antigen family, member 3 ------

cell motility /// actin filament organization /// blood coagulation nucleus /// microtubule organizing 220160_s_at 5.416 1.377E-04 KPTN kaptin (actin binding protein) /// sensory perception of sound actin binding /// actin binding center /// actin cytoskeleton ---

Purine metabolism /// nucleotide binding /// magnesium Pyrimidine metabolism DNA replication /// nucleotide ion binding /// nucleotidase activity /// Nicotinate and 5',3'-nucleotidase, metabolism /// pyrimidine /// hydrolase activity /// metal ion nicotinamide 219708_at 5.057 2.372E-04 NT5M mitochondrial deoxyribonucleotide catabolism binding mitochondrion /// mitochondrion metabolism

GABA-A receptor activity /// ion channel activity /// extracellular ligand-gated ion channel activity /// chloride channel activity /// ion transport /// signal neurotransmitter receptor activity /// integral to plasma membrane /// gamma-aminobutyric acid transduction /// transport /// chloride ion binding /// GABA-A postsynaptic membrane /// 208457_at 5.332 1.540E-04 GABRD (GABA) A receptor, delta transport receptor activity membrane /// integral to membrane ---

erythrocyte membrane protein regulation of cell shape /// peptide structural constituent of cytoskeleton band 4.2 /// erythrocyte cross-linking /// erythrocyte /// ATP binding /// structural cytoskeleton /// plasma membrane 210746_s_at 5.096 2.256E-04 EPB42 membrane protein band 4.2 maturation molecule activity /// cytoskeleton --- chromosome 15 open reading spermatogenesis /// cell 221300_at 6.308 3.885E-05 C15orf2 frame 2 differentiation ------

nucleotide binding /// protein serine/threonine kinase activity /// protein complex assembly /// ATP binding /// transferase activity protein amino acid /// protein kinase activity /// protein phosphorylation /// protein amino serine/threonine kinase activity /// 209622_at 5.741 8.387E-05 STK16 serine/threonine kinase 16 acid phosphorylation kinase activity membrane --- nuclear mRNA splicing, via spliceosome /// protein folding /// protein complex assembly /// peptidyl-prolyl cis-trans isomerase snRNP protein import into activity /// cyclosporin A binding /// peptidylprolyl isomerase H nucleus /// mRNA processing /// isomerase activity /// unfolded nucleus /// spliceosome complex /// 204228_at 5.278 1.665E-04 PPIH (cyclophilin H) protein folding protein binding spliceosome complex ---

transcription /// regulation of transcription corepressor activity /// transcription, DNA-dependent /// protein kinase activity /// protein protein amino acid kinase inhibitor activity /// protein phosphorylation /// negative binding /// protein binding /// ATP regulation of protein kinase binding /// protein kinase binding /// tribbles homolog 3 activity /// apoptosis /// regulation protein kinase binding /// kinase 218145_at 5.857 6.877E-05 TRIB3 (Drosophila) of MAPK activity /// apoptosis activity nucleus /// nucleus ---

intracellular protein transport /// receptor mediated endocytosis /// Golgi trans face /// coated pit /// AP- vesicle-mediated transport /// 1 adaptor complex /// AP-1 adaptor transport /// intracellular protein complex /// coated vesicle adaptor-related protein complex transport /// endocytosis /// protein binding /// protein membrane /// clathrin coat of trans- 209635_at 5.331 1.543E-04 AP1S1 1, sigma 1 subunit protein transport transporter activity Golgi network vesicle ---

nucleotide binding /// uridine kinase activity /// ATP binding /// kinase 209825_s_at 5.158 2.021E-04 UCK2 uridine-cytidine kinase 2 biosynthesis activity /// transferase activity --- Pyrimidine metabolism GTP biosynthesis /// UTP biosynthesis /// CTP biosynthesis /// transcription /// regulation of transcription, DNA-dependent /// cell cycle /// cell adhesion /// negative regulation of cell proliferation /// nucleotide nucleotide binding /// magnesium metabolism /// nucleoside ion binding /// transcription factor triphosphate biosynthesis /// activity /// nucleoside diphosphate negative regulation of kinase activity /// protein binding /// progression through cell cycle /// ATP binding /// kinase activity /// regulation of transcription, DNA- transferase activity /// DNA binding non-metastatic cells 2, protein dependent /// pyrimidine /// nucleoside diphosphate kinase Nucleotide_Metabolism NME2 /// NME1-(NM23B) expressed in /// ribonucleoside triphosphate activity /// ATP binding /// metal ion ruffle /// nucleus /// lamellipodium /// Purine metabolism /// 201268_at 5.635 9.791E-05 NME2 NM23-LV biosynthesis binding /// nucleus Pyrimidine metabolism

1-alkyl-2- acetylglycerophosphocholine nervous system development /// esterase activity /// protein binding lipid catabolism /// lipid /// hydrolase activity, acting on ester platelet-activating factor metabolism /// lipid metabolism bonds /// hydrolase activity /// acetylhydrolase, isoform Ib, /// central nervous system growth factor activity /// growth soluble fraction /// cytoplasm /// 203228_at 5.61 1.019E-04 PAFAH1B3 gamma subunit 29kDa development factor activity membrane /// extracellular region --- protein biosynthesis /// phenylalanyl-tRNA aminoacylation /// tRNA nucleotide binding /// phenylalanine- aminoacylation for protein tRNA ligase activity /// ATP binding translation /// protein biosynthesis /// ligase activity /// aminoacyl-tRNA phenylalanine-tRNA synthetase- /// phenylalanyl-tRNA ligase activity /// phenylalanine- soluble fraction /// cytoplasm /// 202159_at 5.065 2.351E-04 FARSLA like, alpha subunit aminoacylation tRNA ligase activity cytoplasm --- GTP biosynthesis /// UTP biosynthesis /// CTP biosynthesis /// cell cycle /// negative nucleotide binding /// magnesium regulation of cell proliferation /// ion binding /// magnesium ion nucleotide metabolism /// binding /// DNA binding /// nucleoside triphosphate deoxyribonuclease activity /// biosynthesis /// regulation of nucleoside diphosphate kinase apoptosis /// negative regulation activity /// nucleoside diphosphate of progression through cell cycle kinase activity /// ATP binding /// /// pyrimidine ribonucleoside ATP binding /// kinase activity /// triphosphate biosynthesis /// transferase activity /// protein transcription /// regulation of binding /// metal ion binding /// transcription, DNA-dependent /// DNA binding /// transcription factor Nucleotide_Metabolism non-metastatic cells 1, protein regulation of transcription, DNA- activity /// nucleoside diphosphate nucleus /// nucleus /// cytoplasm /// /// Purine metabolism /// 201577_at 5.292 1.636E-04 NME1 (NM23A) expressed in dependent /// cell adhesion kinase activity ruffle /// lamellipodium /// nucleus Pyrimidine metabolism

regulation of progression through cell cycle /// rRNA processing /// telomere maintenance via telomerase /// cell proliferation /// telomerase activity /// RNA binding nucleus /// nucleoplasm /// rRNA processing /// RNA /// pseudouridylate synthase activity telomerase holoenzyme complex /// dyskeratosis congenita 1, processing /// ribosome /// isomerase activity /// RNA nucleolus /// ribonucleoprotein 201479_at 5.256 1.717E-04 DKC1 dyskerin biogenesis /// RNA processing binding complex --- intracellular /// mitochondrion /// mitochondrial ribosomal ribosome /// ribonucleoprotein 222216_s_at 5.023 2.484E-04 MRPL17 protein L17 protein biosynthesis structural constituent of ribosome complex ---

protein folding /// sensory perception of sound /// protein transport /// protein import into zinc ion binding /// metal ion mitochondrial inner membrane /// binding /// unfolded protein binding protein amino acid ADP- /// NAD(P)+-protein-arginine ADP- ribosylation /// chromatin ribosyltransferase activity /// zinc ion mitochondrion /// mitochondrial silencing /// regulation of binding /// DNA binding /// inner membrane presequence transcription, DNA-dependent /// NAD(P)+-protein-arginine ADP- translocase complex /// membrane protein targeting /// protein ribosyltransferase activity /// zinc ion /// mitochondrial intermembrane translocase of inner targeting to mitochondrion /// binding /// transferase activity /// space protein transporter complex mitochondrial membrane 13 transport /// protein targeting to transferase activity, transferring /// nucleus /// nucleus /// chromatin 218188_s_at 5.553 1.108E-04 TIMM13 homolog (yeast) mitochondrion glycosyl groups silencing complex --- Nucleotide_Metabolism purine ribonucleotide adenylosuccinate lyase activity /// /// Purine metabolism /// biosynthesis /// purine nucleotide lyase activity /// catalytic activity /// Alanine and aspartate 202144_s_at 6.624 2.517E-05 ADSL adenylosuccinate lyase biosynthesis adenylosuccinate lyase activity --- metabolism

phosphoribosylaminoimidazole carboxylase activity /// phosphoribosylaminoimidazolesucci nocarboxamide synthase activity /// ATP binding /// lyase activity /// ligase activity /// identical protein phosphoribosylaminoimidazole binding /// catalytic activity /// carboxylase, purine nucleotide biosynthesis /// phosphoribosylaminoimidazolesucci phosphoribosylaminoimidazole 'de novo' IMP biosynthesis /// nocarboxamide synthase activity /// phosphoribosylaminoimidazole Purine metabolism /// 201013_s_at 7.005 1.637E-05 PAICS succinocarboxamide synthetase purine base biosynthesis carboxy-lyase activity carboxylase complex Purine metabolism

nucleotide binding /// tumor necrosis factor receptor binding /// ATP TNF receptor-associated protein folding /// response to binding /// unfolded protein binding 201391_at 5.83 7.131E-05 TRAP1 protein 1 unfolded protein /// receptor activity mitochondrion ---

DNA_replication_React DNA binding /// DNA-directed ome /// Purine polymerase (DNA directed), DNA polymerase activity /// protein metabolism /// delta 2, regulatory subunit DNA replication /// DNA binding /// transferase activity /// Pyrimidine metabolism 201115_at 5.055 2.372E-04 POLD2 50kDa replication nucleotidyltransferase activity nucleus /// nucleus /// DNA polymerase

Electron_Transport_Cha membrane fraction /// in /// Oxidative mitochondrion /// proton- phosphorylation /// ATP transporting ATP synthase complex synthesis /// transporter activity /// lipid binding (sensu Eukaryota) /// membrane /// Photosynthesis /// /// hydrogen-transporting ATP proton-transporting two-sector Flagellar assembly /// synthase activity, rotational ATPase complex /// proton- Type III secretion mechanism /// hydrogen-transporting transporting ATP synthase system /// Epithelial cell ATP synthase, H+ transporting, ion transport /// ATP synthesis ATPase activity, rotational complex, coupling factor F(o) /// signaling in Helicobacter mitochondrial F0 complex, coupled proton transport /// mechanism /// hydrogen ion integral to membrane /// pylori /// Purine 208972_s_at 5.802 7.484E-05 ATP5G1 subunit C1 (subunit 9) proton transport /// transport transporter activity mitochondrial inner membrane metabolism electron transport /// DNA DNA binding /// protein binding /// fragmentation during apoptosis /// electron carrier activity /// disulfide apoptosis /// DNA damage oxidoreductase activity /// programmed cell death 8 response, signal transduction oxidoreductase activity /// FAD nucleus /// mitochondrion /// 205512_s_at 5.664 9.537E-05 PDCD8 (apoptosis-inducing factor) resulting in induction of apoptosis binding nucleus /// mitochondrion --- notchless homolog 1 203867_s_at 5.123 2.153E-04 NLE1 (Drosophila) ------nucleus ---

nucleotide binding /// cyclin- dependent protein kinase activity /// ErbB-2 class receptor binding /// protein binding /// protein binding /// ATP binding /// transferase activity /// acetylcholine receptor activator protein amino acid activity /// ErbB-3 class receptor phosphorylation /// cell cycle /// binding /// tau-protein kinase activity striated muscle development /// /// protein serine/threonine kinase cell proliferation /// embryonic activity /// kinase activity /// protein development /// neuron kinase activity /// protein differentiation /// neurite serine/threonine kinase activity /// nucleus /// cytoplasm /// membrane development /// positive kinase activity /// protein kinase /// axon /// dendrite /// growth cone regulation of neuron apoptosis /// activity /// protein serine/threonine /// neuromuscular junction /// cell 204247_s_at 5.964 5.829E-05 CDK5 cyclin-dependent kinase 5 axon extension /// cell division kinase activity soma --- mRNA_processing_Rea nuclear mRNA splicing, via ctome /// small nuclear ribonucleoprotein spliceosome /// mRNA processing nucleus /// ribonucleoprotein mRNA_processing_bind 200826_at 5.067 2.351E-04 SNRPD2 D2 polypeptide 16.5kDa /// mRNA metabolism protein binding complex ing_Reactome

electron-transfer-flavoprotein, alpha polypeptide (glutaric electron carrier activity /// FAD mitochondrion /// mitochondrial 201931_at 5.081 2.308E-04 ETFA aciduria II) electron transport /// transport binding /// electron carrier activity matrix /// mitochondrion ---

sulfur amino acid metabolism /// transaminase activity /// transferase NFS1 nitrogen fixation 1 (S. protein complex assembly /// activity /// cysteine desulfurase nucleus /// mitochondrion /// cytosol 218455_at 5.215 1.838E-04 NFS1 cerevisiae) metabolism activity /// mitochondrion ---

hydrolase activity, acting on carbon- 218557_at 5.67 9.484E-05 NIT2 nitrilase family, member 2 nitrogen compound metabolism nitrogen (but not peptide) bonds ------protein binding /// electron carrier electron transport /// cell motility activity /// protein disulfide /// signal transduction /// cell-cell oxidoreductase activity /// thiol- signaling /// cell proliferation /// disulfide exchange intermediate 208864_s_at 5.547 1.117E-04 TXN thioredoxin transport activity ------trophinin associated protein 204649_at 5.577 1.083E-04 TROAP (tastin) cell adhesion /// cell adhesion protein binding cytoplasm ---

nucleotide binding /// transcription thyroid hormone receptor transcription from RNA cofactor activity /// ATP binding /// 204033_at 6.494 3.019E-05 TRIP13 interactor 13 polymerase II promoter nucleoside-triphosphatase activity nucleus --- mRNA_processing_Rea mRNA polyadenylylation /// ctome /// cleavage stimulation factor, 3' mRNA cleavage /// RNA mRNA_processing_Rea 203947_at 5.644 9.755E-05 CSTF3 pre-RNA, subunit 3, 77kDa processing /// mRNA processing RNA binding /// binding intracellular /// nucleus /// nucleus ctome