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Supplementary,Table,1.,Tangeretin,Targets,In,Human,,As,Retreived,From,Pubchem Supplementary,Table,1.,Tangeretin,targets,in,human,,as,retreived,from,PuBChem No Protein,name Symbol 1 Unspecific,Monooxygenase 2 Proline,Rich,Protein,Bstni,Subfamily,1 PRB1 3 Caspase,3 CASP3 4 Tumor,Necrosis,Factor CD40LG 5 Bcl2,,Apoptosis,Regulator BCL2 6 Cytochrome,P450,Family,3,Subfamily,A,Member,4CYP3A4 7 Atp,Binding,Cassette,Subfamily,B,Member,1 ABCB1 8 MitogenQActivated,Protein,Kinase MAP3K10 9 Akt,Serine/Threonine,Kinase,1 AKT1 10 Glucuronosyltransferase UGT2A3 11 Heme,Oxygenase,1 HMOX1 12 InterleukinQ6 IL6 13 MitogenQActivated,Protein,Kinase,8 MAPK8 14 InositolQ3QPhosphate,Synthase ISYNA1 15 Bcl2,Like,1 BCL2L1 16 Glutathione,Transferase GSTO1 17 MitogenQActivated,Protein,Kinase,3 MAPK3 18 PhosphatidylinositolQ4QPhosphate,3QKinase PIK3 19 ProstaglandinQEndoperoxide,Synthase,2 PTGS2 20 Tyrosinase TYR 21 Caspase,9 CASP9 22 Protein,Kinase,XQLinked PRKX 23 ProlineQRich,P65,Protein RELA 24 Cytochrome,P450,Family,1,Subfamily,A,Member,2CYP1A2 25 PhosphatidylinositolQ4,5QBisphosphate,3QKinase,Catalytic,Subunit,AlphaPIK3CA 26 Jagged,1 JAG1 27 Nad(+),AdpQRibosyltransferase ART1 28 Cadherin,1 CDH1 29 MitogenQActivated,Protein,Kinase,ErkQA ERK 30 P53 TP53 31 Nad(P)H,Dehydrogenase,(Quinone) NQO2 32 Notch,1 NOTCH1 33 Cyclin,B1 CCNB1 34 Peroxiredoxin,6,Pseudogene,2 PRDX6 35 Mcl1,,Bcl2,Family,Apoptosis,Regulator MCL1 36 Superoxide,Dismutase SOD2 37 Insulin INS 38 Interleukin,10 IL10 39 Cytochrome,P450,Family,1,Subfamily,A,Member,1CYP1A1 40 MethylQCpg,Binding,Domain,Protein,2 MBD2 41 Interleukin,17a IL17A 42 Caspase,8 CASP8 43 Poly,(AdpQRibose),Polymerase PARP 44 Vascular,Endothelial,Growth,Factor,A VEGFA 45 Proliferating,Cell,Nuclear,Antigen PCNA 46 Catalase CAT 47 Udp,Glucuronosyltransferase,Family,1,Member,A9UGT1A9 48 Macrophage,Scavenger,Receptor,1 MSR1 49 Solute,Carrier,Organic,Anion,Transporter,Family,Member,1a2SLCO1A2 50 Udp,Glucuronosyltransferase,Family,2,Member,B7UGT2B7 51 Signal,Transducer,And,Activator,Of,Transcription,3STAT3 52 CQC,Motif,Chemokine,Ligand,2 CCL2 53 Period,Circadian,Regulator,2 PER2 54 Myeloperoxidase MPO 55 Nuclear,Factor,Kappa,B,Subunit,1 NFKB1 56 Quinone,Oxidoreductase,1 CRYZL1 57 XQBox,Binding,Protein,1 XBP1 58 Leucine,Aminopeptidase,2 LAP3P2 59 40s,Ribosomal,Protein,S7 RPS7 60 Glutathione,Peroxidase GPX8 61 Mechanistic,Target,Of,Rapamycin,Kinase MTOR 62 Udp,Glucuronosyltransferase,Family,1,Member,A1UGT1A8 63 Interleukin,23,Subunit,Alpha IL23A 64 Resistin RETN 65 XQLinked,Inhibitor,Of,Apoptosis XIAP 66 Cadherin,17 CDH17 67 Nad(P)H,Quinone,Dehydrogenase,1 NQO1 68 Cd36,Molecule CD36 69 Cyclin,Dependent,Kinase,Inhibitor,1a CDKN1A 70 MitogenQActivated,Protein,Kinase,1 MAPK1 71 Gap,Junction,Protein,Alpha,1 GJA1 72 Forkhead,Box,P3 FOXP3 73 Cd4,Molecule CD4 74 Janus,Kinase,2 JAK2 75 Gelatinase,B MMP9 76 Synuclein,Alpha SNCA 77 Interferon,Lambda,Receptor,1 IFNLR1 78 Atp,Binding,Cassette,Subfamily,G,Member,2,(Junior,Blood,Group)ABCG2 79 Pyruvate,Kinase PKLR 80 Protein,Kinase,AmpQActivated,Catalytic,Subunit,Alpha,2PRKAA2 81 AlphaQAmylase AMY2A 82 Polyamine,Modulated,Factor,1 PMF1 83 Dna,Nucleotidylexotransferase DNTT 84 GlucoseQ6QPhosphate,Dehydrogenase G6PD 85 CyclinQD1Q1 CCND1 86 Taste,2,Receptor,Member,14 TAS2R14 87 Apolipoprotein,B APOB 88 Jun,ProtoQOncogene,,ApQ1,Transcription,Factor,SubunitJUN 89 Adiponectin,,C1q,And,Collagen,Domain,ContainingADIPOQ 90 Cyclin,D CCND1 91 Tyrosine,Hydroxylase TH 92 Tetraspanin,12 TSPAN12 93 Catenin,Beta,1 CTNNB1 94 MitogenQActivated,Protein,Kinase,14 MAPK14 95 Phosphatidylinositol,3QKinase PI3K Supplementary,Table,2.,Genes,related,to,metastatic,breast,cancer,,as,retreived,from,PubMed Symbol Aliases description BRCA2 BRCC2,,BROVCA2,,FACD,,FAD,,FAD1,,FANCD,,FANCD1,,GLM3,,PNCA2,,XRCC11BRCA2,DNA,repair,associated BRMS1 BRMS1,transcriptional,repressor,and,anoikis,regulator BRCA1 BRCAI,,BRCC1,,BROVCA1,,FANCS,,IRIS,,PNCA4,,PPP1R53,,PSCP,,RNF53BRCA1,DNA,repair,associated ESR1 ER,,ESR,,ESRA,,ESTRR,,Era,,NR3A1 estrogen,receptor,1 TERT CMM9,,DKCA2,,DKCB4,,EST2,,PFBMFT1,,TCS1,,TP2,,TRT,,hEST2,,hTRTtelomerase,reverse,transcriptase CCND1 BCL1,,D11S287E,,PRAD1,,U21B31 cyclin,D1 ABCG2 ABC15,,ABCP,,BCRP,,BCRP1,,BMDP,,CD338,,CDw338,,EST157481,,GOUT1,,MRX,,MXR,,MXRV1,,MXR1,,UAQTL1ATP,binding,cassette,subfamily,G,member,2,(Junior,blood,group) FGFR2 BBDS,,BEK,,BFRV1,,CD332,,CEK3,,CFD1,,ECT1,,JWS,,KVSAM,,KGFR,,TK14,,TK25fibroblast,growth,factor,receptor,2 CDKN2A ARF,,CDK4I,,CDKN2,,CMM2,,INK4,,INK4A,,MLM,,MTSV1,,MTS1,,P14,,P14ARF,,P16,,P16VINK4A,,P16INK4,,P16INK4A,,P19,,P19ARF,,TP16cyclin,dependent,kinase,inhibitor,2A BCAS3 GAOB1,,MAAB BCAS3,microtubule,associated,cell,migration,factor MALAT1 HCN,,LINC00047,,NCRNA00047,,NEAT2,,PRO2853metastasis,associated,lung,adenocarcinoma,transcript,1 NME1 AWD,,GAAD,,NB,,NBS,,NDKA,,NDPKVA,,NDPKA,,NM23,,NM23VH1NME/NM23,nucleoside,diphosphate,kinase,1 MTA1 metastasis,associated,1 MTDH 3D3,,AEGV1,,AEG1,,LYRIC,,LYRIC/3D3metadherin KISS1 HH13,,KiSSV1 KiSSV1,metastasis,suppressor PTHLH BDE2,,HHM,,PLP,,PTHR,,PTHRP parathyroid,hormone,like,hormone BRMS1L BRMS1 BRMS1,like,transcriptional,repressor NCOA3 ACTR,,AIBV1,,AIB1,,CAGH16,,CTG26,,KAT13B,,RAC3,,SRCV3,,SRC3,,TNRC14,,TNRC16,,TRAMV1,,bHLHe42,,pCIPnuclear,receptor,coactivator,3 CD82 4F9,,C33,,GR15,,IA4,,KAI1,,R2,,SAR2,,ST6,,TSPAN27CD82,molecule MDM4 HDMX,,MDMX,,MRP1 MDM4,regulator,of,p53 TIAM1 TIAMV1 TIAM,Rac1,associated,GEF,1 SNCG BCSG1,,SR synuclein,gamma MACC1 7A5,,SH3BP4L MET,transcriptional,regulator,MACC1 MYC MRTLC,,bHLHe39,,cVMyc,,MYC MYC,protoVoncogene,,bHLH,transcription,factor RECK ST15 reversion,inducing,cysteine,rich,protein,with,kazal,motifs IGF1 IGF,,IGFVI,,IGFI,,MGF insulin,like,growth,factor,1 CHEK2 CDS1,,CHK2,,HuCds1,,LFS2,,PP1425,,RAD53,,hCds1checkpoint,kinase,2 TFF1 BCEI,,D21S21,,HP1.A,,HPS2,,pNRV2,,pS2trefoil,factor,1 MRTFA BSAC,,MAL,,MKL,,MKL1,,MRTFVA myocardin,related,transcription,factor,A TP53 BCC7,,BMFS5,,LFS1,,P53,,TRP53 tumor,protein,p53 MTA2 MTA1L1,,PID metastasis,associated,1,family,member,2 MTSS1 MIM,,MIMA,,MIMB MTSS,IVBAR,domain,containing,1 MAP3K1 MAPKKK1,,MEKK,,MEKK,1,,MEKK1,,SRXY6mitogenVactivated,protein,kinase,kinase,kinase,1 EGFR ERBB,,ERBB1,,HER1,,NISBD2,,PIG61,,mENAepidermal,growth,factor,receptor ERBB4 ALS19,,HER4,,p180erbB4 erbVb2,receptor,tyrosine,kinase,4 TNF DIFValpha,,TNFA,,TNFSF2,,TNLG1F,,TNFtumor,necrosis,factor VEGFA MVCD1,,VEGF,,VPF vascular,endothelial,growth,factor,A CCAR2 DBCV1,,DBC1,,KIAA1967,,NET35,,p30,DBC,,p30DBCcell,cycle,and,apoptosis,regulator,2 IL6 BSFV2,,BSF2,,CDF,,HGF,,HSF,,IFNVbetaV2,,IFNB2,,ILV6interleukin,6 CDKN2B CDK4I,,INK4B,,MTS2,,P15,,TP15,,p15INK4bcyclin,dependent,kinase,inhibitor,2B TGFB1 CED,,DPD1,,IBDIMDE,,LAP,,TGFVbeta1,,TGFB,,TGFbetatransforming,growth,factor,beta,1 MTA3 metastasis,associated,1,family,member,3 TCF7L2 TCFV4,,TCF4 transcription,factor,7,like,2 ERBB2 CD340,,HERV2,,HERV2/neu,,HER2,,MLN,19,,NEU,,NGL,,TKR1erbVb2,receptor,tyrosine,kinase,2 TGFBR2 AAT3,,FAA3,,LDS1B,,LDS2,,LDS2B,,MFS2,,RIIC,,TAAD2,,TBRVii,,TBRII,,TGFRV2,,TGFbetaVRIItransforming,growth,factor,beta,receptor,2 CDKN2BVAS1ANRIL,,CDKN2BVAS,,CDKN2BAS,,NCRNA00089,,PCAT12,,p15ASCDKN2B,antisense,RNA,1 HIF1A HIFV1Valpha,,HIFV1A,,HIFV1alpha,,HIF1,,HIF1VALPHA,,MOP1,,PASD8,,bHLHe78hypoxia,inducible,factor,1,subunit,alpha AREG ARB,,CRDGF,,SDGF,,AREG amphiregulin MMP9 CLG4B,,GELB,,MANDP2,,MMPV9 matrix,metallopeptidase,9 AR AIS8,,DHTR,,HUMARA,,HYSP1,,KD,,NR3C4,,SBMA,,SMAX1,,TFM,,ARandrogen,receptor AKT1 AKT,,CWS6,,PKB,,PKBVALPHA,,PRKBA,,RAC,,RACVALPHAAKT,serine/threonine,kinase,1 NFKB1 CVID12,,EBPV1,,KBF1,,NFVkB,,NFVkB1,,NFVkappaVB1,,NFVkappaB,,NFKBVp105,,NFKBVp50,,NFkappaB,,p105,,p50nuclear,factor,kappa,B,subunit,1 KLF4 EZF,,GKLF Kruppel,like,factor,4 STAT3 ADMIO,,ADMIO1,,APRF,,HIES signal,transducer,and,activator,of,transcription,3 KRAS 'CVKVRAS,,CVKVRAS,,CFC2,,KVRAS2A,,KVRAS2B,,KVRAS4A,,KVRAS4B,,KVRas,,KVRas,2,,KIVRAS1,,KRAS2,,NS,,NS3,,OES,,RALD,,RASK2,,cVKiVras,,cVKiVras2,,KRASKRAS,protoVoncogene,,GTPase CERS2 L3,,LASS2,,SP260,,TMSG1 ceramide,synthase,2 IL1B ILV1,,IL1VBETA,,IL1F2,,IL1beta interleukin,1,beta PTGS2 COXV2,,COX2,,GRIPGHS,,PGG/HS,,PGHSV2,,PHSV2,,hCoxV2prostaglandinVendoperoxide,synthase,2 IL10 CSIF,,GVHDS,,ILV10A,,TGIF,,IL10 interleukin,10 CRP PTX1 CVreactive,protein TLR4 ARMD10,,CD284,,TLRV4,,TOLL toll,like,receptor,4 CTNNB1 CTNNB,,EVR7,,MRD19,,NEDSDV,,armadillocatenin,beta,1 PTEN 10q23del,,BZS,,CWS1,,DEC,,GLM2,,MHAM,,MMAC11,,PTENbeta,,TEP1,,PTENphosphatase,and,tensin,homolog CXCL8 GCPV1,,GCP1,,IL8,,LECT,,LUCT,,LYNAP,,MDNCF,,MONAP,,NAF,,NAPV1,,NAP1CVXVC,motif,chemokine,ligand,8 NUPR1 COM1,,P8 nuclear,protein,1,,transcriptional,regulator CD44 CDW44,,CSPG8,,ECMRVIII,,HCELL,,HUTCHVI,,IN,,LHR,,MC56,,MDU2,,MDU3,,MIC4,,Pgp1CD44,molecule,(Indian,blood,group) CDH1 ArcV1,,BCDS1,,CD324,,CDHE,,ECAD,,LCAM,,UVOcadherin,1 MTOR FRAP,,FRAP1,,FRAP2,,RAFT1,,RAPT1,,SKSmechanistic,target,of,rapamycin,kinase BCL2 BclV2,,PPP1R50 BCL2,apoptosis,regulator SERPINB5 PI5,,maspin serpin,family,B,member,5 CXCR4 CD184,,D2S201E,,FB22,,HM89,,HSY3RR,,LAPV3,,LAP3,,LCR1,,LESTR,,NPY3R,,NPYR,,NPYRL,,NPYY3R,,WHIM,,WHIMSCVXVC,motif,chemokine,receptor,4 MED19 DT2P1G7,,LCMR1AS,,MED19 mediator,complex,subunit,19 S100A14 BCMP84,,S100A15 S100,calcium,binding,protein,A14 MDM2 ACTFS,,HDMX,,LSKB,,hdm2 MDM2,protoVoncogene MMP2 CLG4,,CLG4A,,MMPV2,,MMPVII,,MONA,,TBEV1matrix,metallopeptidase,2 ACE ACE1,,CD143,,DCP,,DCP1 angiotensin,I,converting,enzyme MAPK1 ERK,,ERKV2,,ERK2,,ERT1,,MAPK2,,P42MAPK,,PRKM1,,PRKM2,,p38,,p40,,p41,,p41mapk,,p42VMAPKmitogenVactivated,protein,kinase,1 CD274 B7VH,,B7H1,,PDVL1,,PDCD1L1,,PDCD1LG1,,PDL1,,hPDVL1CD274,molecule SERPINE1 PAI,,PAIV1,,PAI1,,PLANH1 serpin,family,E,member,1 FHIT AP3Aase,,FRA3B
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