Supplementary Table 2. Genes selected by FADA as the most discriminant between tumoral and normal prostate samples GO Biological Process GO Molecular Function GO Cellular Component GeneID T-test q-val Gene Symbol Gene Title Description Description Description Pathway serine-type endopeptidase inhibitor activity /// endopeptidase inhibitor serpin peptidase inhibitor, clade activity /// serine-type endopeptidase 213572_s_at -6.753 2.213E-05 SERPINB1 B (ovalbumin), member 1 --- inhibitor activity cytoplasm --- ion transport /// cellular defense response /// positive regulation of T-cell, immune regulator 1, cell proliferation /// proton plasma membrane /// integral to ATPase, H+ transporting, transport /// transport /// proton transporter activity /// hydrogen ion plasma membrane /// membrane /// 204158_s_at -5.729 8.585E-05 TCIRG1 lysosomal V0 subunit A3 transport transporter activity integral to membrane --- chemotaxis /// cell adhesion /// homophilic cell adhesion /// nervous system development /// cell differentiation /// positive roundabout, axon guidance regulation of axonogenesis /// receptor activity /// axon guidance integral to plasma membrane /// cell receptor, homolog 1 development /// nervous system receptor activity /// identical protein surface /// membrane /// integral to 213194_at -6.168 4.441E-05 ROBO1 (Drosophila) development binding /// protein binding membrane --- structural molecule activity /// nucleus /// intermediate filament /// protein binding /// microtubule cytoplasmic dynein complex /// 203411_s_at -5.297 1.636E-04 LMNA lamin A/C --- motor activity /// motor activity microtubule /// dynein complex --- transcription factor activity /// skeletal development /// sequence-specific DNA binding /// v-ets erythroblastosis virus E26 regulation of transcription, DNA- DNA binding /// transcription factor Smooth_muscle_contrac 201329_s_at -5.807 7.442E-05 ETS2 oncogene homolog 2 (avian) dependent activity /// DNA binding nucleus tion nucleotide binding /// catalytic activity /// 6-phosphofructo-2-kinase activity /// 6-phosphofructo-2-kinase activity /// fructose-2,6-bisphosphate 2-phosphatase activity /// fructose- 2,6-bisphosphate 2-phosphatase fructose 2,6-bisphosphate activity /// ATP binding /// kinase Fructose and mannose 6-phosphofructo-2- metabolism /// fructose 2,6- activity /// transferase activity /// metabolism /// Fructose kinase/fructose-2,6- bisphosphate metabolism /// hydrolase activity /// identical and mannose 202464_s_at -5.034 2.458E-04 PFKFB3 biphosphatase 3 metabolism protein binding --- metabolism nucleotide binding /// DNA binding /// double-stranded DNA binding /// double-stranded DNA binding /// single-stranded DNA binding /// single-stranded DNA binding /// DNA replication /// DNA RNA binding /// RNA binding /// replication /// RNA processing /// protein binding /// identical protein regulation of translation /// binding /// magnesium ion binding RNA binding motif, single cytokine and chemokine /// protein serine/threonine kinase stranded interacting protein 1 /// mediated signaling pathway /// activity /// ATP binding /// nucleic chromosome 2 open reading regulation of protein complex acid binding /// magnesium ion frame 12 /// region containing disassembly /// protein amino binding /// protein kinase activity /// chromosome 2 open reading acid phosphorylation /// DNA protein serine/threonine kinase RBMS1 /// frame 12; RNA binding motif, replication /// protein amino acid activity /// protein binding /// ATP C2orf12 /// single stranded interacting phosphorylation /// signal binding /// kinase activity /// 215127_s_at -5.066 2.351E-04 LOC648293 protein 1 transduction transferase activity nucleus /// nucleus --- transcription /// regulation of transcription, DNA-dependent /// negative regulation of NGFI-A binding protein 1 transcription /// regulation of transcriptional repressor activity /// 209272_at -6.317 3.885E-05 NAB1 (EGR1 binding protein 1) transcription, DNA-dependent transcriptional repressor activity nucleus /// nucleus --- schwannomin interacting 204030_s_at -6.382 3.490E-05 SCHIP1 protein 1 --- --- cytoplasm --- immune response /// cell surface receptor linked signal CD59 molecule, complement transduction /// blood coagulation protein binding /// GPI anchor membrane fraction /// plasma 200984_s_at -5.554 1.108E-04 CD59 regulatory protein /// defense response binding membrane /// membrane --- nuclear envelope /// cytoplasm /// BCL2/adenovirus E1B 19kDa apoptosis /// anti-apoptosis /// GTPase activator activity /// calcium intracellular membrane-bound 209308_s_at -6.634 2.510E-05 BNIP2 interacting protein 2 apoptosis ion binding /// protein binding organelle --- phospholipase inhibitor activity /// phospholipase inhibitor activity /// calcium ion binding /// calcium- dependent phospholipid binding /// soluble fraction /// plasma Prostaglandin_synthesis 201590_x_at -5.916 6.118E-05 ANXA2 annexin A2 skeletal development cytoskeletal protein binding membrane _regulation plasma membrane /// integral to plasma membrane /// caveolar membrane /// caveolar membrane /// Integrin- protein binding /// protein lipid raft /// perinuclear region /// mediated_cell_adhesion 203323_at -6.351 3.721E-05 CAV2 caveolin 2 --- homodimerization activity membrane /// integral to membrane _KEGG Golgi membrane /// endoplasmic Integrin- reticulum /// integral to plasma mediated_cell_adhesion structural molecule activity /// membrane /// membrane /// integral _KEGG /// Integrin- caveolin 1, caveolae protein, cholesterol transport /// protein binding /// cholesterol to membrane /// caveolar membrane mediated_cell_adhesion 203065_s_at -5.982 5.829E-05 CAV1 22kDa cholesterol homeostasis binding /// caveolar membrane /// lipid raft _KEGG nuclear envelope /// plasma fer-1-like 3, myoferlin (C. membrane /// integral to membrane 201798_s_at -5.295 1.636E-04 FER1L3 elegans) muscle contraction /// circulation --- /// membrane --- membrane fraction /// endoplasmic ion transport /// chemotaxis /// reticulum /// endoplasmic reticulum proteolipid protein 2 (colonic cytokine and chemokine protein binding /// ion transporter membrane /// plasma membrane /// 201136_at -5.399 1.401E-04 PLP2 epithelium-enriched) mediated signaling pathway activity /// chemokine binding integral to membrane /// membrane --- regulation of progression through calcium ion binding /// growth factor cell cycle /// cell cycle /// signal activity /// protein homodimerization transduction /// cell-cell signaling activity /// S100 beta binding /// /// axonogenesis /// cell S100 alpha binding /// calcium- proliferation /// positive dependent protein binding /// protein S100 calcium binding protein regulation of fibroblast binding /// calcium ion binding /// ruffle /// nucleus /// nuclear Prostaglandin_synthesis 217728_at -6.577 2.637E-05 S100A6 A6 (calcyclin) proliferation /// cell cycle calcium ion binding envelope /// cytoplasm /// cytoplasm _regulation development /// cell death /// negative regulation of cell membrane fraction /// membrane /// 203729_at -5.347 1.505E-04 EMP3 epithelial membrane protein 3 proliferation /// cell growth --- integral to membrane --- coronin, actin binding protein, phagocytosis /// signal 221676_s_at -6.067 5.213E-05 CORO1C 1C transduction actin binding actin cytoskeleton --- Smooth_muscle_contrac nucleotide binding /// structural tion /// constituent of cytoskeleton /// Smooth_muscle_contrac AFFX- protein binding /// ATP binding /// cytoskeleton /// actin filament /// tion /// HSAC07/X00351 structural molecule activity /// TIP60 histone acetyltransferase Striated_muscle_contrac _5_at -5.296 1.636E-04 ACTB actin, beta --- protein binding complex tion lysosomal associated protein transmembrane 4 beta /// lysosomal associated protein 208029_s_at -6.207 4.242E-05 LAPTM4B transmembrane 4 beta --- --- integral to membrane --- G_Protein_Signaling /// A kinase (PRKA) anchor G_Protein_Signaling /// AKAP2 /// protein 2 /// PALM2-AKAP2 G_Protein_Signaling /// 202760_s_at -6.23 4.242E-05 PALM2-AKAP2 protein regulation of cell shape kinase activity /// enzyme binding membrane G_Protein_Signaling nucleotide binding /// 5'-nucleotidase activity /// zinc ion binding /// Purine metabolism /// hydrolase activity, acting on ester Pyrimidine metabolism bonds /// metal ion binding /// GPI /// Nicotinate and DNA metabolism /// nucleotide anchor binding /// 5'-nucleotidase nicotinamide 203939_at -5.15 2.046E-04 NT5E 5'-nucleotidase, ecto (CD73) catabolism activity /// hydrolase activity membrane fraction /// membrane metabolism fasciculation and elongation cell adhesion /// nervous system 203562_at -6.61 2.523E-05 FEZ1 protein zeta 1 (zygin I) development /// axon guidance protein binding --- --- squamous cell carcinoma endoplasmic reticulum /// 218854_at -5.984 5.829E-05 SART2 antigen recognized by T cells 2 --- --- membrane /// integral to membrane --- serine-type endopeptidase inhibitor nervous system development /// activity /// heparin binding /// serpin peptidase inhibitor, clade cell differentiation /// regulation endopeptidase inhibitor activity /// E (nexin, plasminogen activator of proteolysis /// regulation of cell serine-type endopeptidase inhibitor 212190_at -5.191 1.906E-04 SERPINE2 inhibitor type 1), member 2 migration /// development activity /// heparin binding extracellular region --- Circadian_Exercise /// Glutathione metabolism anti-apoptosis /// central nervous /// Metabolism of system development /// glutathione transferase activity /// xenobiotics by 200824_at -5.955 5.829E-05 GSTP1 glutathione S-transferase