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THE SYNDROMES of the ARTERIES of the BRAIN and SPINAL CORD Part 1 by LESLIE G

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THE SYNDROMES of the ARTERIES of the BRAIN and SPINAL CORD Part 1 by LESLIE G 65 Postgrad Med J: first published as 10.1136/pgmj.29.328.65 on 1 February 1953. Downloaded from THE SYNDROMES OF THE ARTERIES OF THE BRAIN AND SPINAL CORD Part 1 By LESLIE G. KILOH, M.D., M.R.C.P., D.P.M. First Assistant in the Joint Department of Psychological Medicine, Royal Victoria Infirmary and University of Durham Introduction general circulatory efficiency at the time of the Little interest is shown at present in the syn- catastrophe is of the greatest importance. An dromes of the arteries of the brain and spinal cord, occlusion, producing little effect in the presence of and this perhaps is related to the tendency to a normal blood pressure, may cause widespread minimize the importance of cerebral localization. pathological changes if hypotension co-exists. Yet these syndromes are far from being fully A marked discrepancy has been noted between elucidated and understood. It must be admitted the effects of ligation and of spontaneous throm- that in many cases precise localization is often of bosis of an artery. The former seldom produces little more than academic interest and ill effects whilst the latter frequently determines provides Protected by copyright. nothing but a measure of personal satisfaction to infarction. This is probably due to the tendency the physician. But it is worth recalling that the of a spontaneous thrombus to extend along the detailed study of the distribution of the bronchi affected vessel, sealing its branches and blocking and of the pathological anatomy of congenital its collateral circulation, and to the fact that the abnormalities of the heart, was similarly neglected arterial disease is so often generalized. until the prospect of therapeutic application In this paper the various syndromes resulting demonstrated the fallacy of this attitude. from occlusion of the arteries of the brain and Cerebral thromboses are usually the expression spinal cord will be described in the light of our of diffuse vascular disease and often it is neither present knowledge. The pathology of the occlusive possible nor profitable to implicate named vessels. process will not be considered, nor will the Optimistic conclusions have often been expressed slowly developing syndromes due to diffuse in the past regarding the specific effects ofocclusion cerebrovascular disease be discussed. The of one particular vessel, but are difficult to accept anatomy and distribution of the vessel in question in view of the ultimate demonstration of will be outlined briefly before its syndromes are multiple http://pmj.bmj.com/ lesions. Cases of cerebral embolism would seem described. to provide a better prospect of accurate study but are less common; many vessels are seldom, if Internal Carotid Artery ever, involved and the opportunity of making The internal carotid artery enters the skull pathological studies becomes very remote when through the carotid canal and runs forwards the smaller-and in many respects more interesting through the cavernous sinus to the medial aspect -vessels are affected. Cerebral angiography may of the anterior clinoid process. Here it turns in the future offer an alternative to post-mortem upwards and at the commencement of the Sylvian on September 26, 2021 by guest. examination and provide a chance of identifying fissure divides into its terminal branches-the the site of the primary occlusion at a time when the anterior and middle cerebral arteries. clinical picture remains uncomplicated. Such The results of occlusion of the internal carotid studies as that made by Ethelberg (I95I) of the artery are extremely varied. The condition is a anterior cerebral artery, are likely to lead to a chance finding at arteriography in a number of rapid expansion of our knowledge of these syn- patients who have none of the anticipated symp- dromes. toms or signs. Certainly surgical ligation of the The varied effects of occlusion of any particular vessel-if proper precautions are taken-rarely artery in different individuals depends on several gives rise to any disability. factors. The extent of the territory supplied and When symptoms do occur, the onset is often the efficacy of the collateral circulation differ gradual. Persistent headache of a migrainous widely from person to person. The degree of character on the same side as the thrombosis may 66 POSTGRADUATE MEDICAL JOURNAL February I953 Postgrad Med J: first published as 10.1136/pgmj.29.328.65 on 1 February 1953. Downloaded from occur for years before other features develop. third of the putamen, the outermost part of the Transient attacks of focal weakness, of focal globus pallidus and the anterior limb of the internal paraesthesiae or of dysphasia are common and capsule. rarely generalized convulsions may occur. The (b) Anterior communicating artery-which often suggestion has been made that these transient gives off a few twigs to the optic chiasma and in- disturbances result from spasm of the smaller fundibular region (Rubenstein, I944). cerebral vessels reflexly induced by impulses from (c) Branches from the convexity: (i) Prefrontal nerve endings in the wall of the diseased internal or orbital branch supplying the medial aspect of carotid artery. In other cases an acute onset is the frontal lobe. (ii) Frontopolar branch-to the seen. The left internal carotid is affected much most anterior portion of the superior frontal more frequently than the right. gyrus. (iii) Calloso-marginal artery which divides The full syndrome that might be expected on into anterior, middle and posterior internal anatomical grounds is seen only occasionally. frontal branches supplying the medial portion of Ipsilateral anosmia is sometimes present. There 'the convexity of the frontal lobe. (iv) Paracentral is blindness of the ipsilateral eye--which may be artery-to the paracentral lobule. (v) Superior transient-due to involvement of the ophthalmic parietal branch. (vi) Precuneal branch-to the artery, while the opposite eye shows a temporal *region of the quadrate lobule. (vii) Parieto- field defect due to a lesion of the optic tract and occipital branch. radiation, Optic atrophy develops in the blind eye. (d) Branches from the concavity: (i) Numerous A severe contralateral hemiplegia and hemi- twigs to the corpus callosum and to the anterior anaesthesia are also present, together with a severe pillars of the fornix. (ii) Pericallosal artery which dysphasia if the major hemisphere is affected. lies deep to the anterior cerebral artery and con- Although mental changes of the organic reaction tinues the line of this vessel. have been attributed to occlusion of the inter- both anterior cerebral arteries arise type Occasionally Protected by copyright. nal carotid artery, their occurrence is so haphazard from the same internal carotid and sometimes only as to suggest that their presence is coincidental. one vessel is present. Cases of lesser severity are far more numerous. The most common picture is that of a moderately Occlusion of the Main Trunk Proximal to Heubner's severe hemiplegia accompanied by a hemi- Artery anaesthesia of lesser severity with astereognosis Much depends on the size of the anterior com- and some degree of dysphasia. It is obvious that municating artery. If this is large and not there may be nothing characteristic about the obstructed by the thrombus, occlusion of the condition and its differentiation, particularly from main trunk of the anterior cerebral artery will occlusion of the middle cerebral artery or one of either produce no ill effects or give rise to a syn- its branches, can only be made by carotid arterio- drome similar to that following thrombosis of graphy. Heubner's artery. If the collateral circulation is (See Elvidge and Werner, 195i; Fisher, I95I.) inadequate the resulting syndrome is much more consciousness is lost. serious. In most cases http://pmj.bmj.com/ The Anterior Cerebral Artery Dandy (I930) as the result of some unfortunate From its origin at the medial end of the Sylvian experiences following the tying of the left anterior fissure, the anterior cerebral artery runs forwards cerebral artery, maintained that total occlusion of and medially across the anterior perforated sub- this vessel always resulted in stupor or coma from stance and above the optic nerve to the margin which recovery did not occur. Many cases have between the medial and orbital surfaces of the since been recorded in which ligation produced no frontal lobe. At this point the vessels of either ill effects (Poppen, I939). Major convulsions may side are connected by the anterior communicating occur and the eyes and head may be turned to on September 26, 2021 by guest. artery. Each then turns abruptly upwards to the side of the lesion due to the unbalanced action reach the genu of the corpus callosum and runs of the opposite frontal eye field (area 8). When backwards in the depths of the longitudinal fissure, the patient is conscious it may also be found that he finally emerging from it to end in the quadrate has some defect of lateral conjugate movement of lobe or the parieto-occipital fissure. Branches: his eyes to the opposite side because of the damage (a) Basal: (i) Several fine branches enter the to the ipsilateral eye field. These features are anterior perforated substance and supply the head short-lived and disappear in a few days or weeks. of the caudate nucleus. (ii) Recurrent artery Mental changes--including all the organic re- (artery of Heubner). This pierces the lateral ex-. action types-may occur and are regarded by some tremity of the anterior perforated substance and authors as a specific part of the clinical picture, but passes upwards and outwards to supply the this cannot be maintained. Patients showing these anterior part of the caudate nucleus, the anterior conditions are usually old and have diffuse February 1953 KILOH: The Syndromes of the Arteries of the Brain and Spinal Cord 67 Postgrad Med J: first published as 10.1136/pgmj.29.328.65 on 1 February 1953.
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