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July 2020 Strategies for Emerging Infectious Diseases
THE AMERICAN WWW.CAYMANCHEM.COM ASSOCIATION OF IMMUNOLOGISTS AT ISSUE NEW THE DOWNLOAD Virus Life Cycle Infographic Infographic Cycle Life Virus JULY 2020 Resources for Your Research Your for Resources Informative Articles Informative CAYMAN CURRENTS: CAYMAN IN THIS ISSUE OF THE THE OF ISSUE THIS IN DISEASES INFECTIOUS EMERGING AAI Looks Back: How Honolulu’s Chinatown FOR STRATEGIES "Went Up in Smoke" A history of the first plague outbreak in Hawai’i, page 30 ANTIVIRAL 28 No. Permit CAYMAN CURRENTS PA Gettysburg, PAID 20852 20852 20852 20852 MD MD MD MD Rockville, Rockville, Rockville, Rockville, 650, 650, 650, 650, Suite Suite Suite Suite Pike, Pike, Pike, Pike, Rockville Rockville Rockville Rockville 1451 1451 1451 1451 Postage U.S. Non-Proft Org. Non-Proft IMMUNOLOGISTS IMMUNOLOGISTS IMMUNOLOGISTS IMMUNOLOGISTS OF OF OF OF ASSOCIATION ASSOCIATION ASSOCIATION ASSOCIATION AMERICAN AMERICAN AMERICAN AMERICAN THE THE THE THE 2020 advanced Course in Immunology Now Virtual! I July 26–31, 2020 IN THIS ISSUE Director: Wayne M. Yokoyama, M.D. Washington University School of Medicine in St. Louis x4 Executive Offce The American Association Don’t miss the premier course in immunology for research scientists! of Immunologists x8 Public Affairs This intensive course is directed toward advanced trainees and scientists who wish to expand or update 1451 Rockville Pike, Suite 650 their understanding of the feld. Leading experts will present recent advances in the biology of the Rockville, MD 20852 20 Members in the News immune system and address its role in health and disease. This is not an introductory course; Tel: 301-634-7178 attendees will need to have a frm understanding of the principles of immunology. -
Year 11 GCSE History Paper 1 – Medicine Information Booklet
Paper 1 Medicine Key topics 1 and 2 (1250-1500, 1500-1700) Year 11 GCSE History Paper 1 – Medicine Information booklet Medieval Renaissance 1250-1500 1500-1750 Enlightenment Modern 1900-present 1700-1900 Case study: WW1 1 Paper 1 Medicine Key topics 1 and 2 (1250-1500, 1500-1700) Key topic 1.1 – Causes of disease 1250-1500 At this time there were four main ideas to explain why someone might become ill. Religious reasons - The Church was very powerful at this time. People would attend church 2/3 times a week and nuns and monks would care for people if they became ill. The Church told people that the Devil could infect people with disease and the only way to get better was to pray to God. The Church also told people that God could give you a disease to test your faith in him or sometimes send a great plague to punish people for their sins. People had so much belief in the Church no-one questioned the power of the Church and many people had believed this explanation of illness for over 1,000 years. Astrology -After so many people in Britain died during the Black Death (1348-49) people began to look for new ways to explain why they became sick. At this time doctors were called physicians. They would check someone’s urine and judge if you were ill based on its colour. They also believed they could work out why disease you had by looking at where the planets were when you were born. -
Early History of Infectious Disease
© Jones and Bartlett Publishers. NOT FOR SALE OR DISTRIBUTION CHAPTER ONE EARLY HISTORY OF INFECTIOUS 1 DISEASE Kenrad E. Nelson, Carolyn F. Williams Epidemics of infectious diseases have been documented throughout history. In ancient Greece and Egypt accounts describe epidemics of smallpox, leprosy, tuberculosis, meningococcal infections, and diphtheria.1 The morbidity and mortality of infectious diseases profoundly shaped politics, commerce, and culture. In epidemics, none were spared. Smallpox likely disfigured and killed Ramses V in 1157 BCE, although his mummy has a significant head wound as well.2 At times political upheavals exasperated the spread of disease. The Spartan wars caused massive dislocation of Greeks into Athens triggering the Athens epidemic of 430–427 BCE that killed up to one half of the population of ancient Athens.3 Thucydides’ vivid descriptions of this epidemic make clear its political and cultural impact, as well as the clinical details of the epidemic.4 Several modern epidemiologists have hypothesized on the causative agent. Langmuir et al.,5 favor a combined influenza and toxin-producing staphylococcus epidemic, while Morrens and Chu suggest Rift Valley Fever.6 A third researcher, Holladay believes the agent no longer exists.7 From the earliest times, man has sought to understand the natural forces and risk factors affecting the patterns of illness and death in society. These theories have evolved as our understanding of the natural world has advanced, sometimes slowly, sometimes, when there are profound break- throughs, with incredible speed. Remarkably, advances in knowledge and changes in theory have not always proceeded in synchrony. Although wrong theories or knowledge have hindered advances in understanding, there are also examples of great creativity when scientists have successfully pursued their theories beyond the knowledge of the time. -
Unique Epitopes on Cεmx in Ige–B Cell Receptors Are Potentially Applicable for Targeting Ige-Committed B Cells
Unique Epitopes on CεmX in IgE−B Cell Receptors Are Potentially Applicable for Targeting IgE-Committed B Cells This information is current as Jiun-Bo Chen, Pheidias C. Wu, Alfur Fu-Hsin Hung, of October 1, 2021. Chia-Yu Chu, Tsen-Fang Tsai, Hui-Ming Yu, Hwan-You Chang and Tse Wen Chang J Immunol 2010; 184:1748-1756; Prepublished online 18 January 2010; doi: 10.4049/jimmunol.0902437 http://www.jimmunol.org/content/184/4/1748 Downloaded from Supplementary http://www.jimmunol.org/content/suppl/2010/01/13/jimmunol.090243 Material 7.DC1 http://www.jimmunol.org/ References This article cites 52 articles, 19 of which you can access for free at: http://www.jimmunol.org/content/184/4/1748.full#ref-list-1 Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision by guest on October 1, 2021 • No Triage! Every submission reviewed by practicing scientists • Fast Publication! 4 weeks from acceptance to publication *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2010 by The American Association of Immunologists, Inc. All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. The Journal of Immunology Unique Epitopes on C«mX in IgE–B Cell Receptors Are Potentially Applicable for Targeting IgE-Committed B Cells Jiun-Bo Chen,*,† Pheidias C. -
History and Scope of Microbiology the Story of Invisible Organisms
A study material for M.Sc. Biochemistry (Semester: IV) Students on the topic (EC-1; Unit I) History and Scope of Microbiology The story of invisible organisms Dr. Reena Mohanka Professor & Head Department of Biochemistry Patna University Mob. No.:- +91-9334088879 E. Mail: [email protected] MICROBIOLOGY 1. WHAT IS A MICROBIOLOGY? Micro means very small and biology is the study of living things, so microbiology is the study of very small living things normally too small that are usually unable to be viewed with the naked eye. Need a microscope to see them Virus - 10 →1000 nanometers Bacteria - 0.1 → 5 micrometers (Human eye ) can see 0.1 mm to 1 mm Microbiology has become an umbrella term that encompasses many sub disciplines or fields of study. These include: - Bacteriology: The study of bacteria - Mycology: Fungi - Protozoology: Protozoa - Phycology: Algae - Parasitology: Parasites - Virology: Viruses WHAT IS THE NEED TO STUDY MICROBIOLOGY • Genetic engineering • Recycling sewage • Bioremediation: use microbes to remove toxins (oil spills) • Use of microbes to control crop pests • Maintain balance of environment (microbial ecology) • Basis of food chain • Nitrogen fixation • Manufacture of food and drink • Photosynthesis: Microbes are involved in photosynthesis and accounts for >50% of earth’s oxygen History of Microbiology Anton van Leeuwenhoek (1632-1723) (Dutch Scientist) • The credit of discovery of microbial world goes to Anton van Leeuwenhoek. He made careful observations of microscopic organisms, which he called animalcules (1670s). • Antoni van Leeuwenhoek described live microorganisms that he observed in teeth scrapings and rain water. • Major contributions to the development of microbiology was the invention of the microscope (50-300X magnification) by Anton von Leuwenhoek and the implementation of the scientific method. -
The Main Events in the History of Diabetes Mellitus
Chapter 1 The Main Events in the History of Diabetes Mellitus Jacek Zajac, Anil Shrestha, Parini Patel, and Leonid Poretsky In Antiquity A medical condition producing excessive thirst, continuous urination, and severe weight loss has interested medical authors for over three millennia. Unfortunately, until the early part of twentieth century the prognosis for a patient with this condition was no better than it was over 3000 years ago. Since the ancient physicians described almost exclusively cases of what is today known as type 1 diabetes mellitus, the outcome was invariably fatal. Ebers Papyrus, which was written around 1500 BC, excavated in 1862 AD from an ancient grave in Thebes, Egypt, and published by Egyptologist Georg Ebers in 1874, describes, among various other ailments and their remedies, a condition of “too great emptying of the urine” – perhaps, the reference to diabetes mellitus. For the treatment of this condition, ancient Egyptian physicians were advocating the use of wheat grains, fruit, and sweet beer.1,2 Physicians in India at around the same time developed what can be described as the first clinical test for dia- betes. They observed that the urine from people with diabetes attracted ants and flies. They named the condition “madhumeha” or “honey urine.” Indian physicians also noted that patients with “madhumeha” suffered from extreme thirst and foul breath (probably, because of ketosis). Although the polyuria associated with diabetes was well recognized, ancient clinicians could not distinguish between the polyuria due to what we now call diabetes mellitus from the polyuria due to other conditions.3 Around 230 BC, Apollonius of Memphis for the first time used the term “diabetes,” which in Greek means “to pass through” (dia – through, betes – to go). -
The Deadly Styx River and the Death of Alexander
Princeton/Stanford Working Papers in Classics The Deadly Styx River and the Death of Alexander Version 1.3 May 2011 Adrienne Mayor Stanford University and Antoinette Hayes Pfizer Pharmaeuticals Abstract: Plutarch, Arrian, Diodorus, Justin, and other ancient historians report that rumors of poisoning arose after the death of Alexander in Babylon in 323 BC. Alexander’s close friends suspected a legendary poison gathered from the River Styx in Arcadia, so corrosive that only the hoof of a horse could contain it. It’s impossible to know the real cause of Alexander’s death, but a recent toxicological discovery may help explain why some ancient observers believed that Alexander was murdered with Styx poison. We propose that the river harbored a killer bacterium that can occur on limestone rock deposits. This paper elaborates on our Poster presentation, Toxicological History Room, XII International Congress of Toxicology, Barcelona, 19-23 July 2010, and Society of Toxicology Annual Meeting, Washington DC, March 2011. © Adrienne Mayor. [email protected] 2 THE DEADLY STYX RIVER and the DEATH OF ALEXANDER THE GREAT Adrienne Mayor and Antoinette Hayes According to several ancient historians, rumors of poisoning circulated after the death of Alexander, at age 32, in Babylon in 323 BC (Bosworth 1971 and 2010; Lane Fox 2004). Some close friends suspected a legendary poison gathered from the Styx waterfall near Nonacris in Arcadia (north central Peloponnese, Greece), a substance reputed to be so corrosive it could only be contained in the hoof of a horse. Many ancient and modern writers have speculated on the true cause of Alexander’s death, which remains an unsolved mystery. -
Streptococci
STREPTOCOCCI Streptococci are Gram-positive, nonmotile, nonsporeforming, catalase-negative cocci that occur in pairs or chains. Older cultures may lose their Gram-positive character. Most streptococci are facultative anaerobes, and some are obligate (strict) anaerobes. Most require enriched media (blood agar). Streptococci are subdivided into groups by antibodies that recognize surface antigens (Fig. 11). These groups may include one or more species. Serologic grouping is based on antigenic differences in cell wall carbohydrates (groups A to V), in cell wall pili-associated protein, and in the polysaccharide capsule in group B streptococci. Rebecca Lancefield developed the serologic classification scheme in 1933. β-hemolytic strains possess group-specific cell wall antigens, most of which are carbohydrates. These antigens can be detected by immunologic assays and have been useful for the rapid identification of some important streptococcal pathogens. The most important groupable streptococci are A, B and D. Among the groupable streptococci, infectious disease (particularly pharyngitis) is caused by group A. Group A streptococci have a hyaluronic acid capsule. Streptococcus pneumoniae (a major cause of human pneumonia) and Streptococcus mutans and other so-called viridans streptococci (among the causes of dental caries) do not possess group antigen. Streptococcus pneumoniae has a polysaccharide capsule that acts as a virulence factor for the organism; more than 90 different serotypes are known, and these types differ in virulence. Fig. 1 Streptococci - clasiffication. Group A streptococci causes: Strep throat - a sore, red throat, sometimes with white spots on the tonsils Scarlet fever - an illness that follows strep throat. It causes a red rash on the body. -
Universidade Do Estado Do Rio De Janeiro Centro Biomédico Faculdade De Ciências Médicas
i Universidade do Estado do Rio de Janeiro Centro Biomédico Faculdade de Ciências Médicas Guilherme da Silva Lourenço Carvalho Formação de biofilme por espécies de Stretptococcus Rio de Janeiro 2012 ii Guilherme da Silva Lourenço Carvalho Formação de biofilme por espécies de Streptococcus Dissertação apresentada, como requisito parcial para obtenção do título de Mestre, ao Programa de Pós-graduação em Microbiologia, da Universidade do Estado do Rio de Janeiro. Área de concentração: Microbiologia Médica Humana. Orientadora: Profa. Dra. Vânia Lúcia Carreira Merquior Coorientadores: Prof. Dr. Rafael Silva Duarte Profa. Dra. Lúcia Teixeira Martins Rio de Janeiro 2012 iii CATALOGAÇÃO NA FONTE UERJ/REDE SIRIUS/BIBLIOTECA CB-A C331 Carvalho, Guilherme da Silva Lourenço. Formação de biofilme por espécies de Streptococcus. / Guilherme da Silva Lourenço Carvalho. - 2012. 79 f. Orientadora: Vânia Lúcia Carreira Merquior. Coorientadores: Rafael Silva Duarte. Lúcia Teixeira Martins. Dissertação (Mestrado) - Universidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas. Pós-graduação em Microbiologia. 1. Streptococcus. 2. Biofilmes. 3. Virulência. I. Merquior, Vânia Lúcia Carreira II. Duarte, Rafael Silva III. Martins, Lúcia Teixeira. IV. Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. V. Título. CDU 576.951.214 Bibliotecária: Ana Rachel Fonseca de Oliveira CRB7/6382 Autorizo, apenas para fins acadêmicos e científicos, a reprodução total ou parcial desta dissertação, desde que citada a fonte. ________________________________________ _____________________ Assinatura Data iv Guilherme da Silva Lourenço Carvalho Formação de biofilme porespécies de Streptococcus Dissertação apresentada, como requisito parcial para obtenção do título de Mestre, ao Programa de Pós-graduação em Microbiologia, da Universidade do Estado do Rio de Janeiro. -
Athmosperic Pollen Count.Pdf
REVI EW ARTICLES t The usefulness of biomarkers of airway inflammation in managing asthma Patil and Long ORIGINAL ARTICLES t Efficacy and safety of mometasone furoate/formoterol 200/10 mcg combination treatment in patients with persistent asthrna previously on mediurn-dose ICSs Nathan el al t Efficacy and safety of mometasone furoate/formoterol 200/10 mcg and 400/10 mcg combination treatments in patients with persistent asthma previously on high-dose ICSs Weinstein et al t Levocetirizine dihydrochloride in pedía trie allergic rhinitis or chronic urticaria Hampel et al t Oral olopatadine hydrochloride for the treatment of SAR Yamamoto et al t Epinephrine auto-injector use in a V.A. population Amirzadeh et al t Repeat epinephrine treatment for food-related allergic reactions Banerji et al t Reduced clinic, ER and hospital utilization after home environmental assessment Barnes et al t Immunotherapy for treatment of allergic asthma in children Alzakar nnd Alsamarai t Acetaminophen for preventing rnood and rnemory effects of prednisone Brown et al t Irnportant Florida botanical aeroallergens Pl1illips et al , t Atmospheric pollen count in Monterrey, Mexico Gonzalez-Diaz et al t DNA repair gene XRCCl polymorphisms and the risk of asthma Batar et nl t POPS Case: A 41-year-old male with cough, wheeze, and dyspnea poorly responsive to asthma therapy Ricketti et al ALLERGY and ASTHMA PROCEEDINGS Editor-in-Chief: Joseph A. Bellanti, MD Associate Editor: Russell A. Settipane, MD Executive Editorial Board American Board Members: Sami L. Bahna, MD Lawrence D. Frenkel, MD Kevin McGrath, MD Shreveport, LA Rockford, IL Fairfield, CT William Berger, MD Marianne Frieri, MD Christopher C. -
PREPARATION of MICROARRAY for DISEASE DETECTION - a SURVEY on DIFFERENT METHODS Kavitha B1, Manjusha G Y2, Sachin D’Souza3 & Hemalatha N4
International Journal of Latest Trends in Engineering and Technology Special Issue SACAIM 2017, pp. 088-090 e-ISSN:2278-621X PREPARATION OF MICROARRAY FOR DISEASE DETECTION - A SURVEY ON DIFFERENT METHODS Kavitha B1, Manjusha G Y2, Sachin D’Souza3 & Hemalatha N4 Abstract- Microarray is a pattern of ssDNA probes which are immobilized on a surface called a chip or a slide.It is used to detect the expression of thousands of gene at the same time. Microarrays (biochip) plays an important role in the drug discovery. The biochip is used to monitor changes in gene expression in response to drug treatments and also used to examine the response of the host against pathogen. The oligonucleotide microarrays provides a rapid, specific and high throughput means for the detection and identification of the food-borne pathogens. In this paper we have described microarray-based tests or methods for detecting the various kinds of diseases. By using several methods and tools like allergen microarray one can screen the serum IgE reactivity. cDNA microarrays has been developed for analysing estrogen responsive genes and in detecting anti hormone therapy. Evaluation of the potential of pathogenicity is determined by detection of a range of virulence factors and serotype determination. Micro RNA identifier array used for the detection of various type of micro RNA in human or for simultaneous detection and genotyping of different virus types in a single reaction. Keywords- Microarray, DNA, RNA,Gene 1. INTRODUCTION Microarray is multiplex lab on a chip. It is a pattern of ssDNA probes which are immobilized on a surface called chip or a slide. -
157Th Meeting of the National Park System Advisory Board November 4-5, 2015
NORTHEAST REGION Boston National Historical Park 157th Meeting Citizen advisors chartered by Congress to help the National Park Service care for special places saved by the American people so that all may experience our heritage. November 4-5, 2015 • Boston National Historical Park • Boston, Massachusetts Meeting of November 4-5, 2015 FEDERAL REGISTER MEETING NOTICE AGENDA MINUTES Meeting of May 6-7, 2015 REPORT OF THE SCIENCE COMMITTEE NATIONAL PARK SERVICE URBAN AGENDA REPORT ON THE NATIONAL PARK SERVICE COMPREHENSIVE ECONOMIC VALUATION STUDY OVERVIEW OF NATIONAL PARK SERVICE ACTIONS ON ADVISORY BOARD RECOMMENDATIONS • Planning for a Future National Park System • Strengthening NPS Science and Resource Stewardship • Recommending National Natural Landmarks • Recommending National Historic Landmarks • Asian American Pacific Islander, Latino and LGBT Heritage Initiatives • Expanding Collaboration in Education • Encouraging New Philanthropic Partnerships • Developing Leadership and Nurturing Innovation • Supporting the National Park Service Centennial Campaign REPORT OF THE NATIONAL HISTORIC LANDMARKS COMMITTEE PLANNING A BOARD SUMMARY REPORT MEETING SITE—Boston National Historical Park, Commandant’s House, Charlestown Navy Yard, Boston, MA 02139 617-242-5611 LODGING SITE—Hyatt Regency Cambridge, 575 Memorial Drive, Cambridge, MA 62139 617-492-1234 / Fax 617-491-6906 Travel to Boston, Massachusetts, on Tuesday, November 3, 2015 Hotel Check in 4:00 pm Check out 12:00 noon Hotel Restaurant: Zephyr on the Charles / Breakfast 6:30-11:00 am / Lunch 11:00 am - 5:00 pm / Dinner 5-11:00 pm Room Service: Breakfast 6:00 am - 11:00 am / Dinner 5:00 pm - 11:00 pm Wednesday NOVEMBER 4 NOTE—Meeting attire is business. The tour will involve some walking and climbing stairs.