Selenium Hexafluoride INTERIM 1: 11-2007 1 2 3 INTERIM ACUTE EXPOSURE GUIDELINE LEVELS (Aegls) 5 for 6 Selenium Hexafluoride 7 (CAS Reg
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Selenium Hexafluoride INTERIM 1: 11-2007 1 2 3 INTERIM ACUTE EXPOSURE GUIDELINE LEVELS (AEGLs) 5 FOR 6 Selenium Hexafluoride 7 (CAS Reg. No. 7783-79-1) 8 9 Se-F6 10 11 12 13 14 15 16 17 18 19 20 21 22 Selenium Hexafluoride INTERIM 1: 11-2007 1 INTERIM ACUTE EXPOSURE GUIDELINE LEVELS (AEGLs) 3 FOR 4 SELENIUM HEXAFLUORIDE 5 (CAS Reg. No. 7783-79-1) 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 4 Selenium Hexafluoride INTERIM 1: 11-2007 1 2 3 4 5 PREFACE 6 7 Under the authority of the Federal Advisory Committee Act (FACA) P. L. 92-463 of 8 1972, the National Advisory Committee for Acute Exposure Guideline Levels for Hazardous 9 Substances (NAC/AEGL Committee) has been established to identify, review and interpret 10 relevant toxicologic and other scientific data and develop AEGLs for high priority, acutely toxic 11 chemicals. 12 13 AEGLs represent threshold exposure limits for the general public and are applicable to 14 emergency exposure periods ranging from 10 minutes to 8 hours. Three levels C AEGL-1, 15 AEGL-2 and AEGL-3 C are developed for each of five exposure periods (10 and 30 minutes, 1 16 hour, 4 hours, and 8 hours) and are distinguished by varying degrees of severity of toxic effects. 17 The three AEGLs are defined as follows: 18 19 AEGL-1 is the airborne concentration (expressed as parts per million or milligrams per 20 cubic meter [ppm or mg/m3]) of a substance above which it is predicted that the general 21 population, including susceptible individuals, could experience notable discomfort, irritation, or 22 certain asymptomatic, non-sensory effects. However, the effects are not disabling and are 23 transient and reversible upon cessation of exposure. 24 25 AEGL-2 is the airborne concentration (expressed as ppm or mg/m3) of a substance above 26 which it is predicted that the general population, including susceptible individuals, could 27 experience irreversible or other serious, long-lasting adverse health effects or an impaired ability 28 to escape. 29 30 AEGL-3 is the airborne concentration (expressed as ppm or mg/m3) of a substance above 31 which it is predicted that the general population, including susceptible individuals, could 32 experience life-threatening health effects or death. 33 34 Airborne concentrations below the AEGL-1 represent exposure levels that could produce 35 mild and progressively increasing but transient and nondisabling odor, taste, and sensory 36 irritation or certain asymptomatic, non-sensory effects. With increasing airborne concentrations 37 above each AEGL, there is a progressive increase in the likelihood of occurrence and the severity 38 of effects described for each corresponding AEGL. Although the AEGL values represent 39 threshold levels for the general public, including susceptible subpopulations, such as infants, 40 children, the elderly, persons with asthma, and those with other illnesses, it is recognized that 41 individuals, subject to unique or idiosyncratic responses, could experience the effects described 42 at concentrations below the corresponding AEGL 43 44 5 Selenium Hexafluoride INTERIM 1: 11-2007 1 TABLE OF CONTENTS 2 PREFACE ....................................................................................................................... 5 3 LIST OF TABLES ........................................................................................................... 8 4 EXECUTIVE SUMMARY ................................................................................................ 9 5 1. INTRODUCTION.................................................................................................... 11 6 2. HUMAN TOXICITY DATA ..................................................................................... 11 7 3. ANIMAL TOXICITY DATA..................................................................................... 11 8 3.1. Acute Toxicity..............................................................................................................................................11 9 3.2. Developmental/Reproductive Toxicity ......................................................................................................12 10 3.3. Genotoxicity .................................................................................................................................................12 11 3.4. Chronic Toxicity/Carcinogenicity..............................................................................................................12 12 3.5. Summary......................................................................................................................................................12 13 4. SPECIAL CONSIDERATIONS .............................................................................. 13 14 4.1. Metabolism and Disposition .......................................................................................................................13 15 4.2. Mechanism of Toxicity................................................................................................................................13 16 4.3. Structure Activity Relationships................................................................................................................13 17 4.4. Other Relevant Information.......................................................................................................................14 18 4.4.1. Species Variability ..................................................................................................................................14 19 4.4.2. Susceptible Populations..........................................................................................................................14 20 4.4.3. Concentration-Exposure Duration Relationship .................................................................................14 21 4.4.4. Concurrent Exposure Issues..................................................................................................................14 22 5. DATA ANALYSIS FOR AEGL-1 ........................................................................... 14 23 5.1. Summary of Human Data Relevant to AEGL-1.......................................................................................14 24 5.2. Summary of Animal Data Relevant to AEGL-1 .......................................................................................14 25 5.3. Derivation of AEGL-1.................................................................................................................................15 26 6. DATA ANALYSIS FOR AEGL-2 ........................................................................... 15 27 6.1. Summary of Human Data Relevant to AEGL-2.......................................................................................15 6 Selenium Hexafluoride INTERIM 1: 11-2007 1 6.2. Summary of Animal Data Relevant to AEGL-2 .......................................................................................15 2 6.3. Derivation of AEGL-2.................................................................................................................................15 3 7. DATA ANALYSIS FOR AEGL-3 ........................................................................... 16 4 7.1. Summary of Human Data Relevant to AEGL-3.......................................................................................16 5 7.2. Summary of Animal Data Relevant to AEGL-3 .......................................................................................16 6 7.3. Derivation of AEGL-3.................................................................................................................................16 7 8. SUMMARY OF AEGLS ......................................................................................... 16 8 8.1. AEGL Values and Toxicity Endpoints ......................................................................................................17 9 8.2. Comparison with Other Standards and Guidelines .................................................................................17 10 8.3. Data Adequacy and Research Needs .........................................................................................................18 11 9. REFERENCES....................................................................................................... 18 12 APPENDIX A: DERIVATION OF AEGL VALUES....................................................... 20 13 APPENDIX B: DERIVATION SUMMARY FOR SELENIUM HEXAFLUORIDE AEGLS 14 ...................................................................................................................................... 23 15 APPENDIX C: CATEGORY PLOT FOR SELENIUM HEXAFLUORIDE ..................... 26 16 7 Selenium Hexafluoride INTERIM 1: 11-2007 1 LIST OF TABLES 2 3 TABLE 1. Summary of AEGL Values for Selenium Hexafluoride ............................................ 10 4 TABLE 2. Chemical and Physical Properties.............................................................................. 11 5 TABLE 3. Time to Death (min) for Animals Exposed to Selenium Hexafluoride for 4-hours . 12 6 TABLE 4. AEGL-1 Values for Selenium Hexafluoride.............................................................. 15 7 TABLE 5. AEGL-2 Values for Selenium Hexafluoride.............................................................. 16 8 TABLE 6. AEGL-3 Values for Selenium Hexafluoride.............................................................. 16 9 TABLE 7. Summary of AEGL Values.......................................................................................