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Non-Steroidal Anti-Inflammatory Drugs (NSAID)

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Non-Steroidal Anti-Inflammatory Drugs (NSAID) Non-steroidal anti-inflammatory drugs (NSAID) Phenylbutazone and others in the spotlight Non-steroidal anti-inflammatory drugs Also the usage as doping agent cannot (NSAID) are a group of pharmaceutical be excluded. actives providing analgesic (pain- The approval of phenylbutazone for relieving), antipyretic (fever-reducing) human application varies from country to and, in higher doses, anti-inflammatory country. In some countries, such as effects. Members of these substance Germany, phenylbutazone is approved classes are well-known OTC and pre- for human application although only scription drugs for human applications short-term administration is recom- such as aspirin, ibuprofen or diclofenac. mended due to its various side effects. In Other representatives such as carprofen, other countries, such as the US and UK, vedaprofen and phenylbutazone (”bute”) phenylbutazone is no longer approved for play a role in animal applications, with human use due to its side effects. the latter being prohibited in food- producing animals. Food regulation Veterinary & human Within Europe, residues of NSAIDs in applications food are harmonised within Regulation (EC) No. 37/2010. Animal and tissue Based on their analgesic, antipyretic and specific maximum levels are listed for anti-inflammatory effects, NSAIDs are carprofen, diclofenac, firocoxib, flunixin, used to treat or prevent diseases or tran- meloxicam, metamizol, tolfenamic acid quilise during transportation or before and vedaprofen. slaughtering. Phenylbutazone is often administered to sport horses for pain relief from infections and musculoskeletal disorders. Phenylbutazone and mefenamic acid are not The analysis of phenylbutazone as single sub- approved for food-producing animals, no maxi- stance as well as a comprehensive NSAID test- mum levels are established resulting in a zero- ing protocol is offered using tandem HPLC-MS tolerance for these substances in the food covering the following actives (LOQ): chain. carprofen (50 μg/kg) Presence in the food chain diclofenac (3 μg/kg) flunixin (10 μg/kg) Within previous National Residue Control Plans phenylbutazone has been identified in the 5-hydroxy-flunixin (5 μg/kg) plasma of a very few number of animals (e.g. in mefenamic acid (10 μg/kg) cattle, cows and horse within the German National Residue Control Plan 2010 and 2011). meloxicam (10 μg/kg) No data for the transfer from plasma to meat phenylbutazone (5 μg/kg) tissue are available for phenylbutazone. The German Federal Institute for Risk Assessment tolfenamic acid (30 μg/kg) (Bundesinsitut für Risikobewertung, BfR) vedaprofen (30 μg/kg) regards the transfer of phenylbutazone from plasma to meat tissue as being limited. The standard turn-around-time is 7 days. Rush An overview of the portfolio service within 1, 2, or 3 days is also available on request. Experts of Eurofins from the Competence A qualitative high-resolution LC-MS/MS screen- Centre for Veterinary Drug Analysis have long- ing method for phenylbutazone metabolite term experience with the analysis of veterinary oxyphenbutazone complements our analytical drug residues for a large variety of matrices. portfolio for NSAIDs. The standard portfolio covers well above 150 Please contact us for your individual offering! veterinary drugs. Eurofins provides a broad range of screening and confirmation methods from single substance to multi-class analysis. 11 PUID 16 16GMJ611 Eurofins Food & Feed Testing Germany [email protected] – www.eurofins.de The information included in this publication is based on our current knowledge and was thoroughly verified. Nevertheless there is no guarantee for it to be up-to-date, complete and correct. Eurofins is not to be held liable for damages or injury, which are connected to the use of this information. Especially the confirmation of legal details is up to the user. All offers are non-binding and without obligation. .
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