The Journalof

VOLUME248 PHARMACOLOGY tERF( 1989 AND EXPERIMENTAL THERAPEUTICS

CONTENTS

Dietary Choline Intake Modulates Benzodiazepine Receptor Binding and y-Aminobutyric AcidA Receptor Function in Mouse Brain. Lawrence G. Miller, David J. Greenblatt, R. Beth Roy, Fred Lopez and Lynn Wecker 1 Inhibitors of Neutral Endopeptid.aae Potentiate Electrically and Capsaicin-Induced Noncholinergic Contraction in Guinea Pig Bronchi. T. D. Djokic, J. A. Nadel, D. J. Dusser, K. Sekizawa, P. D. Graf and D. B. Borson 7 Cholinergic Receptors in Renal Medullary Collecting Duct Cells. Shari McArdle, Lal C. Garg and Fulton T. Crews 12 Obesity as a Risk Factor in Drug-Induced Organ Injury. IV. Increased Gentamicin Nephrotoxicity in the Obese Overfed Rat. George B. Corcoran and Daniel E. Sala.zar 17

Effects of the Thromboxane Synthesis Inhibitor CGS-12970 on Experimental Acute Renal Allograft Rejection. Downloaded from Martin J. Mangino, Elizabeth M. Brunt, Peter Von Doersten and Charles B. Anderson 23 Discriminative Stimulus Properties of Midazolam in the Pigeon. Suzette M. Evans and Chris E. Johanson 29 Cardioprotective Effects of a New Vascular Intracellular Calcium Antagonist, KT-362, in the Stunned Myocar- dium. Neil E. Farber and Garrett J. Gross 39 Effects of Exogenous Vasoconstrictors on Coronary Vascular Resistance and Prostacyclin Production of the Quies-

cent Heart: The Inhibitory Effect of Aspirin. Shwu-Luan Lee, Sidney Levitsky and Harold Feinberg 44 jpet.aspetjournals.org Effects of Buspirone and Its Metabolite, 1-(2-Pyrimidinyl)piperazine, on Brain Monoamines and Their Metabolites in Rats. Ray W. Fuller and Kenneth W. Perry 50 Cardiovascular Effects of Cocaine: Enhancement by Yohimbine and Atropine. R. Douglas Wilkerson 57 Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on Lipid Synthesis and Lipogenic Enzymes in the Rat. M. R. Laksh- man, Stuart J. Chirtel, Laura L. Chambers and Peter J. Coutlakis 62 Oxidant Stress Stimulates Active Transport of Serotonin by Platelets. Talmage R. Bosin 67 [3H]CTOP, a Potent and Highly Selective Peptide for Mu Opioid Receptors in Rat Brain. Kumiko N. Hawkins, Richard at ASPET Journals on September 29, 2021 J. Knapp, George K. Lw, Karoly Gulya, Wieslaw Kazmierski, Y.-P. Wan, John T. Pelton, Victor J. Hruby and Henry I. Yamamura 73 Effects of Experimental Diabetes on Biochemical and Functional Characteristics of Bladder Muscarinic Receptors. Jamshid Latifpour, Angelo Gousse, Shun Kondo, Takashi Morita and RObert M. Weiss 81 CGS 20625, a Novel Pyrazolopyridine Anxiolytic. Michael Williams, Debra A. Bennett, Patricia S. Loo, Albert F. Braun- walder, Caryl L. Amrick, Douglas E. Wilson, Thomas N. Thompson, Markus Schmutz, Nao Yokoyoma and Jan W. F. Wasley 89 Absence of Spare Autoreceptors Regulating Dopamine Agonist Inhibition of Tyrosine Hydroxylation in Slices of Rat Striatum. Karen Bohmaker, Tracy Puza, Menek Goldstein and Emanuel Meller 97 Aging: Ouabain-Sensitive 56Rb Uptake Rate and Responsiveness to Digoxin in Rat Left Atrial Muscle. Richard H. Kennedy and Ernst Seifen 104 Spontaneous Regeneration of Free Muscarinic Receptor after Alkylation by BM 123. I. Recovery in Vivo and in Cell Culture. Jerene J. Waite and Donald J. Jenden 111 Spontaneous Regeneration of Free Muscarinic Receptor after Alkylation by BM 123. II. Recovery in Broken Cell Preparations. Jerene J. Waite and Donald J. Jenden 119 Acute Opioid Physical Dependence in Postaddict Humans: Naloxone Dose Effects after Brief Morphine Exposure. Stephen J. Heishman, Maxine L. Stitzer, George E. Bigelow and Ira A. Liebson 127 Atrial Natriuretic Factor Inhibits Adrenergic and Purinergic Neurotranamission in the Rabbit Isolated Vas Defer- ens. James G. Drewett, George J. Trachte and Gary R. Marchand 135 Effects of Clinically Effective Concentrations of Halothane on Adrenergic and Cholinergic Synapses in Rat Brain in Vitro. Carl W. Bazil and Kenneth P. Minneman 143 Glyburide Blocks the Relaxation Response to BRL 34915 (Cromakalim), Minoxidil Sulfate and Diazoxide in Vas- cular Smooth Muscle. Raymond J. Winquist, Lisa A. Heaney, Audrey A. Wallace, Elizabeth P. Baskin, Robert B. Stein, Maria Luisa Garcia and Gregory J. Kaczorowski 149 Protection by L-2-Oxothiazolidine-4-Carboxylate, a Cysteine Prodrug, Against 1,1-Dichioroethylene Hepatotox- icity in Rats is Associated with Decreases in Toxin Metabolism and Cytochrome P-450. Mary Treinen Moslen, Robert F. Whitehead, Ann E. Ferguson and Mary F. Kanz 157 Effects of McN-6186 on Voltage-Dependent Ca Channels in Heart and Pituitary Cells. D. Rampe, A. Skatteb#{248}l,D. J. Triggle and A. M. Brown 164 Dopamine- 1 Agonist, SKF 82526, Stimulates Phospholipase-C Activity Independent of Adenylate Cyclase. Christian C. Felder, Pedro A. Jose and Julius Axelrod 171

Contents Continued on iv Contents Continued from iii

Contribution of Metabolites to the Route- and Time-Dependent Hepatic Effects of di-(2-Ethylhexyl)phthalate in

the Rat. Gary M. Pollack, Danny D. Shen and Mary Beth Dorr . 176 Epitope Characterization of Acetaminophen Bound to Protein and Nonprotein Sulfhydryl Groups by an Enzyme- Linked Immunosorbent Assay. David W. Potter, Neil R. Pumford, Jack A. Hinson, R. Wayne Benson and Dean W. Roberts 182 Immunochemical Quantitation of 3-(Cystein-S-yl)acetaminophen Adducts in Serum and Liver Proteins of Acetaminophen-Treated Mice. Neil R. Pumford, Jack A. Hinson, David W. Potter, Kenneth L. Rowland, R. Wayne Benson and Dean W. Roberts 190 Comparison of the 5-HT3 Receptor Antagonist Properties of ICS 205-930, GR38032F and Zacopride. Marlene L. Cohen, William Bloomquist, Jaswant S. Gidda and William Lacefield 197 Gradient in the Effects of Ethyl Alcohol on Canine Gastric Antral Circular Muscles. Kenton M. Sanders, J. Brian Reed and Robert G. Berry 202 Inhibition of Gastric Acid Secretion in Vivo and in Vitro by a New Calmodulin Antagonist, CGS 9343B. E. W. Black, S. J. Strada, R. L. Garrett, Jr., P. R. Kvietys, W. J. Thompson and J. A. Norman 208 Demonstration of Specific Dopamine- 1 Receptor-Mediated Coronary Vasodilation in the Anesthetized Dog. Gregory A. Kopia and Richard E. Valocik 215 Manganese-Mediated Increase in the Rat Brain Mitochondrial Cytochrome P-450 and Drug Metabolism Activity: Susceptibility of the Striatum. John J. Liccione and Mahin D. Maines 222 Vasoactivity of 20-Hydroxyeicosatetraenoic Acid is Dependent on Metabolism by Cyclooxygenase. Bruno Escalante, William C. Sessa, J. R. Faick, Pendri Yadagiri and Michal Laniado Schwartzman 229 Downloaded from Localization and Characterization of Alpha-2 Adrenoceptors in the Isolated Canine Pulmonary Vein. Eliot H. Ohl- stein, Stephen Horohonich, Ronald J. Shebuski and Robert R. Ruffolo, Jr 233 ICI 147,798: A Slowly Dissociable Beta Adrenoceptor Antagonist that Causes Insurmountable Beta-i and Sur- mountable Beta-2 Adrenoceptor Antagonism in Isolated Tissues. R. A. Keith, T. F. Hwang, V. S. Murthy, S. T. Kau, A. I. Salama and R. E. Giles 240

Insurmountable Beta Receptor Blockade by ICI i47,798 in Rabbits. V. S. Murthy, T. F. Hwang, R. Wurm, M. E. Zagar, jpet.aspetjournals.org R. A. Keith, S. T. Kau, A. I. Salama and R. E. Giles 249 Age-Related Differences in the Sensitivity of Opiate-Induced Perturbations in Reproductive Endocrinology in the Developing and Adult Male Rat. Theodore J. Cicero, Lynn O’Connor, Bruce Nock, Michael L. Adams, Brian T. Miller, Roy D. Bell and Edward R. Meyer 256 Inhibition of Naloxone-Resistant Antinociception by Centrally Administered H2-Antagonists. K. R. Gogas and L. B. Hough 262

Bradykinin Stimulates Eleetrogenic Bicarbonate Secretion by the Guinea Pig Gallbladder. A. W. Baird and H. S. at ASPET Journals on September 29, 2021 Margolius 268 Morphine Blocks and Naloxone Enhances Suppression of Operant Behavior by Low Doses of 3-Isobutyl-i-Meth- ylxanthine. Mark S. Kleven and Sheldon B. Sparber 273 Effect of Acute or Chronic Administration of Imipramine on Spinal and Supraspinal Micturition Reflexes in Rats. Carlo Alberto Maggi, Franco Borsini, Alessandro Lecci, Sandro Giuliani, Paola Meli, Lucia Gragnani and Alberto Meli 278 Effects of Ketoprofen and Indomethacin on Leukocyte Migration in Two Models of Pleurisy Induced by Car- rageenan or Zymosan-Activated Serum in Rats. Edouard Vannier, Monique Roch-Arveiller, Bernard Molinie, Bernard Terlain and Jean-Paul Giroud 286 Influence of Epithelium on Guinea Pig Airway Responses to Tachykinins: Role of Endopeptidase and Cyclox- ygenase. N. Frossard, K. J. Rhoden and P. J. Barnes 292 Mu and Delta Opioid Receptors Inhibit Serotonin Release in Rat Hippocampus. Francesca Passarelli and Tommaso Costa 299 Beneficial Effects of Lidocaine and Disopyramide on Oxygen-Deficiency-Induced Contractile Failure and Meta- bolic Disturbance in Isolated Rabbit Hearts. Satoshi Takeo, Kouichi Tanonaka, Kaori Shimizu, Katsumi Hirai, Keiko Miyake and Reiko Minematsu 306 Paraxanthine Metabolism in Humans: Determination of Metabolic Partial Clearances and Effects of Allopurinol and Cimetidine. Aznan Lelo, Gunnar Kjellen, Donald J. Birkett and John 0. Miners 315 Neocortical Epileptogenesis in Vitro: Studies with N-Methyl-D-Aspartate, Phencyclidine, Sigma and Dex-

tromethorphan Receptor Ligands. J. A. Aram, D. Martin, M. Tomczyk, S. Zeman, J. Millar, G. Pohler and D. Lodge ... 320 Plasma Arginine Vasopressin Response to Intravenous Methadone and Naloxone in Conscious Dogs. L. J. Helle- brekers, W. E. van den Brom and J. A. Mol 329 Differential Inhibition by Aspirin of Platelet Thromboxane and Renal Prostaglandins in the Rat. Manuela Livio, Ariela Benigni, Carla Zoja, Raffaella Begnis, Carla Morelli, Magda Rossini, Silvio Garattini and Giuseppe Remuzzi 334 Interaction of the Prejunctional Inhibitory Action of 5-Hydroxytryptamine on Noradrenergic Transmission with Neuronal Amine Uptake in Rabbit Isolated Ear Artery. Alan G. Meehan and David F. Story 342 In Vivo Mechanisms for the Enhanced Acetylation of Sulfamethazine in the Rabbit after Hydrocortisone Treat- ment. Philip T. Reeves, Rodney F. Minchin and Kenneth F. Ilett 348 Role of Lipoxygenase Metabolites for the Hyper-Responsiveness to Platelet-Activating Factor of Lungs from Ac- tively Sensitized Guinea Pigs. Marina Pretolani, Jean Lefort, Claude Dumarey and B. Boris Vargaftig 353 Inhibition of Gentamicin-Induced Nephrotoxicity by Pyridoxal-5’-Phosphate in the Rat. S. Kacew 360

Contents Continued on v Contents Continued from iv

Altered Responsiveness to Sympathetic Nerve Stimulation and Agonists of Isolated Left Atria of Diabetic Rats: No Evidence for Involvement of Hypothyroidism. Natauki Sato, Hisakuni Hashimoto, Yoshiharu Takiguchi and Mitsuyoshi Nakashima 367 Effects of Coronary Flow, Pacing Rate, Isoprenaline and Diltiazem on Ischemic Ventricular Arrhythmias in Guinea Pig Hearts. S. C. Dennis, W. A. Coetzee, J. W. de Jong, W. Clusin and L. H. Opie 372 Cholecystokinin, But Not Gastrin, Induces y-Aminobutyric Acid Release from Myenteric Neurons of the Guinea Pig Ileum. I. Sano, K. Taniyama and C. Tanaka 378 Contractile Actions of Epidermal Growth Factor-Urogastrone in Isolated Smooth Muscle Preparations from Guinea Pig Stomach: Structure-Activity Relationships and Comparison with the Effects of Human Transforming Growth Factor-Alpha. M. D. Hollenberg, I. Muramatsu, H. Itoh, P. Patel, S.-G. Yang and K. Lederis 384 Pharmacological Profile of Moclobemide, a Short-Acting and Reversible Inhibitor of Monoamine Oxidase Type A. Willy P. Burkard, Erico P. Bonetti, Mos#{233}Da Prada, James R. Martin, Peter Polc, Rudoff Schaffner, Richard Scherschlicht, Fridolin Hefti, Rita K. M. Muller, Pierre-Charles Wyss and Willy Haefely 391 Neurochemical Profile of Moclobemide, a Short-Acting and Reversible Inhibitor of Monoamine Oxidase Type A. Mos#{233}Da Prada, Rolf Kettler, Hans H. Keller, Willy P. Burkard, Daniela Muggli-Maniglio and Willy E. Haefely 400 In Vitro Effects of Ciprofloxacin and Pefloxacin on Growth of Normal Human Hematopoietic Progenitor Cells and on Leukemic Cell Lines. Eli Somekh, Dan Douer, Nih Shaked and Ethan Rubinstein 415 Neuronal Uptake and Metabolism of 2- and 6-Fluorodopaniine: False Neurotransmitters for Positron Emission Downloaded from Tomographic Imaging of Sympathetically Innervated Tissues. Graeme Eisenhofer, David Hovevey-Sion, Irwin J. Ko- pin, Robert Miletich, Kenneth L. Kirk, Ronald Finn and David S. Goldstein 419 Renal Clearance of Substituted Hippurates in the Dog. I. Benzoylglycine (Hippurate) and Methyl-Substituted Ben- zoylglycines. Frans G. M. Russel, Alfons C. Wouterse and Cees A. M. van Ginneken 428 Renal Clearance of Substituted Hippurates in the Dog. II. 4-Amino-, Hydroxy- and Methoxy-Substituted Ben- zoylglycines. Frans G. M. Russel, Alfons C. Wouterse and Cees A. M. van Ginneken 436

Morphine, Capsaicin and K Release Purines from Capsaicin-Sensitive Primary Afferent Nerve Terminals in the jpet.aspetjournals.org Spinal Cord. Marva I. Sweeney, Thomas D. White and Jana Sawynok 447 Calcitonin Gene-Related Peptide and Vasod.ilator Nerves in Large Cerebral Arteries of Cats. Akira Saito, Tomoh Masaki, Yasuo Uchiyama, Tony J.-F. Lee and Katsutoshi Goto 455 Electrophysiological Actions of Ro5-4864 on Cerebellar Purkinje Neurons: Evidence for “Peripheral” Ben- zodiazepine Receptor-Mediated Depression. Anthony S. Basile, Gordon T. Bolger, Hartmut W. M. Lueddens and Phil Skolnick 463

Neuroanatomically Selective Down-Regulation of Beta Adrenergic Receptors by Chronic Imipramine Treatment: at ASPET Journals on September 29, 2021 Relationships to the Topography of [3H]Imipramine and [3HjDesipramine Binding Sites. Gary E. Duncan, Ian A. Paul, Kelly R. Powell, Jonathan B. Fassberg, Walter E. Stumpf and George R. Breese 470 Erratum 478