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LESSON 9 DEVELOPMENT of GENITOURINA RY SYSTEM Objectives by the End of This Lesson, You Should Be Able To: - 1

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LESSON 9 DEVELOPMENT of GENITOURINA RY SYSTEM Objectives by the End of This Lesson, You Should Be Able To: - 1 LESSON 9 DEVELOPMENT OF GENITOURINA RY SYSTEM Objectives By the end of this lesson, you should be able to: - 1. Describe the origin of the urogenital system 2. Describe the development of the male and female urinary system 3. Describe the development of the male and the female gonads 4. Describe the development of the male and the female accessory structures of reproduction 5. Describe the development of the male and the female external genitalia Introduction The urogenital system can be divided functionally into the urinary system and the genita l system. • Embryologically and anatomically, however, they are closely connected. • The urogenital system develops from the intermediate mesoderm which extends along the dorsal body wall of the embryo. • The intermediate mesoderm later loses its connection with the somites and forms a longitudinal elevation of the mesoderm called the urogenital ridge . • Part of the urogenital ridge giving rise to the urinary tract is known as the nephrogenic cord . • Medial part of the urogenital ridge forms the gonadal (genital) ridge . • The mesothelial lining of the peritoneal cavity and the endoderm of the urogenital sinus also take part in the development of the urogenital system. Urogenital ridge 1. Gut 2. Gonad 3. Bowman's capsule 4. Mesonephric duct 5. Excretory tubule of mesonephros 6. Glomerulus 7. Mesentery URINARY SYSTEM KIDNEY • During the intrauterine life, three separate excretory systems arise successively. 1. The pronephros - This is nonfunctional and undergoes complete regression soon after its formation. 2. The mesonephros - serves as a temporary excretory organ. The body of the mesonephros undergoes degenerative changes, but caudal parts of the mesonephric tubules and mesonephric duct persist in the male. 3. The metanephros – This is a definitive structure Pronepros 1. Nephrotomes 2. Pronephric tubuli 3. Pronephric duct 1. Excretory units 2. Mesonephric duct 3. Nephrogenic cord 1. Cloaca 2. Metanephric mesoderm 3. Ureteric bud PRONEPHROS The pronephros appears early in the fourth week as segmentally arranged cell (nephrotomes ) and tubular (pronephric tubuli) structures in the cervical region of the intermediate mesoderm. The pronephric tubules open into the intraembryonic coelom (coelomic cavity), while the pronephric duct runs caudally and opens into the cloaca. By the beginning of the 5th week, the regression of the vestigial nephrotomes is complete . Pronepros 1. Pronephric tubule 2. Glomerulus 3. Dorsal aorta 4. Splanchnic mesoderm 5. Somatic mesoderm 6. Intraembryonic cavity 7. Neural tube 8. Yolk sac 9. Endoderm MESONEPROS • Late in the 4th week, caudal to the rudimentary pronephros. • The nephrogenic cord, from the first thoracic to the third lumbar segment, differentiates into mesonephric vesicles which elongate to form an S-shaped loops (tubules). • At their medial end, Bowman's capsule forms a mesonephric (renal) corpuscle together with the glomerulus . • At the opposite end, the tubules enter the mesonephric (Wolffian ) duct . • Some parts of the mesonephric (Wolffian) duct do not completely disappear, but they persist in the male as the epididymis duct, ductus deferens, seminal vesicle and ejaculatory duct . • Also, some of the mesonephric tubules near the gonad persists in the male as the efferent ductules of the testis. Mesonepros 1. Gut 2. Gonad 3. Bowman's capsule 4. Mesonephric duct 5. Excretory tubule of mesonephros 6. Glomerulus 7. Mesentery Mesonephros and developing gonad 1. Gonad 2. Interstinal loop 3. Mesonephric duct 4. Neural tube 5. Mesonephros METANEPHROS • The definitive kidney or metanephros originates from two mesodermal rudiments: the ureteric bud (metanephric diverticulum) and the metanephric mesoderm (metanephrogenic blastema). • The collecting system develops from the ureteric bud, a dorsal outgrowth of the mesonephric (Wolffian ) duct close to its entrance into the cloaca. • The bud penetrates the metanephric mesoderm forming the ampulla , which undergoes a series of repeated bifurcations. • The ureteric bud gives rise to the ureter, renal pelvis, major and minor calyces and collecting tubules within the kidney. Development of the renal pelvis • Metanephric mesoderm develops from the sacral portion of the nephrogenic cord. • Under the inductive influence of the ampulla, the metanephric mesoderm differentiates into renal vesicles and than into S-shaped tubules. • The tubules give rise to the excretory parts of the metanephros, called nephrons . • A nephron consists of the Bowman's capsule, the proximal convoluted tubule, the loop of Henle, and the distal convoluted tubule. Developmen t of the renal pelvis 1 . Metanephric mesoderm 2 . Ureteric bud Developm ent of the renal pelvis 1. Metanephr ic mesoderm 2. Ureteric bud 3. Pelvis 4. Major calyx Development of the renal pelvis 1. Metanephric mesoderm 2. Ureteric bud 3. Collecting tubules 4. Pelvis Development of the nephron 1. Metanephric tissue cups 2. Ampulla 3. Collecting tubule 4. Metanephric mesoderm Development of the nephron 1. Metanephric tissue cups 2. Cell clusters 3. Renal vesicle 4. Collecting tubule Development of the nephron 1. Nephron 2. Bowman's capsule 3. Metanephric mesoderm 4. Collecting tubule Development of the nephron 1. Bowman's capsule 2. Distal convoluted tubule 3. Collecting tubules Development of the nephron 1. Distal convoluted tubule 2. Glomerulus 3. Collecting tubules 4. Proximal convoluted tubule 5. Henle's loop 6. Bowman's capsule Development of the metanephros • The metanephros originates in the pelvic region. • Between the 6th to 8th week of the development, the metanephros ascends to the lumbar region, because of the disproportionate growth of the lumbar and sacral region. • During the kidney ascent to the abdominal level it rotates medially almost 90º. • Initially, the kidney hilum faces ventrally, but is finally directed anteromedially after the ascent and rotation. Ascent of the kidney 1. Urogenital ridge 2. Genital ridge 3. Mesonephric duct 4. Mesonephros 5. Gonad 6. Metanephric tissue 7. Ureter 8. Cloacal membrane 9. Cloaca 10. Allantois 11. Urorectal septum 12. Tail Ascent of the kidney 1. Mesonephric duct 2. Mesonephros 3. Gonad 4. Metanephros 5. Ureter 6. Cloacal membrane 7. Cloaca 8. Urorectal septum 9. Urogenital sinus 10. Anorectal canal 11. Tail Ascent of the kidney 1 . Ureter 2 . Metanephros 3 . Gonad 4 . Mesonephric duct 5 . Anal membrane 6 . Urogenital membrane 7 . Perineal body 8 . Bladder 9 . Rectum URETER, URINARY BLADDER AND THE URETHRA • The ureters develop from the caudal portion of the ureteric bud . • The urinary bladder and urethra are derived from the primitive urogenital sinus (a ventral part of the cloaca) and adjacent splanchnic mesenchyme. • The cloaca, the terminal portion of the hindgut is divided into the dorsal primitive rectum and ventral primitive urogenital sinus by the growth of the urorectal septum. • The same septum also divides cloacal membrane into the urogenital membrane anteriorly , and the anal membrane posteriorly. Development of urogenital sinus 1. Mesonephric duct 2. Mesonephros 3. Gonad 4. Metanephros 5. Ureter 6. Cloacal membrane 7. Cloaca 8. Urorectal septum 9. Urogenital sinus 10. Anorectal canal 11. Tail Formation of the urogenital sinus 1 . Ureter 2 . Metanephros 3 . Gonad 4 . Mesonephric duct 5 . Anal membrane 6 . Urogenital membrane 7 . Perineal body 8 . Bladder 9 . Rectum Development of the urinary bladder • The urogenital sinus gives rise to the urinary bladder, which is cranially continuous with allantois (later urachus ) and caudally with the urethra. • During division of the cloaca the caudal portions of the mesonephric ducts are incorporated into the wall of the urinary bladder thus forming the trigone of the bladder. • The ureters and mesonephric ducts with time obtain the separate entrances into the urinary bladder. • In the male, the pelvic part of the urogenital sinus gives rise to the prostatic and membranous part of the urethra . • The penile urethra is partly formed by the closure of urethral folds, while its most distal portion is formed by an inward penetration of ectodermal cells on the tip of the glans. Development of the bladder and ureters 1. Ureter 2. Mesonephric duct 3. Urinary bladder Development of the bladder and ureters 1. Ureter 2. Mesonephric duct 3. Urinary bladder GENITAL SYSTEM • The genital system consists of the gonads, associated genital ducts and external genitalia. • Although the genetic sex of an embryo is determined at the time of fertilization, male and female genital systems are similar until the 7th week of the development ( indifferent gonads stage ). GONADS • The gonads (testes and ovaries) are derived from three sources: the mesothelium (coelomic epithelium) lining the posterior abdominal wall, the underlying gonadal ridge mesenchyme, and the primordial germ cells (precursors of spermatogonia or oogonia). Urogenital ridge 1. Mesothelium 2. Gonadal ridge mesenchyme 3. Gut 4. Bowman's capsule 5. Longitudinal mesonephric duct 6. Excretory tubule of mesonephros 7. Glomerulus Development of the gonads • The primordial germ cells first appear in the wall of the yolk sac and in the 6th week and migrate along the dorsal mesentery of the hindgut to the genital ridges. • Genital ridges form a thickened area comprising mesothelium and underlying mesenchyme on the medial side of the mesonephros. • Epithelium of the genital ridge proliferates and penetrates the underlying mesenchyme, forming the primitive sex cords . Indifferent gonad 1. Coelomic epithelium 2. Primitive
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