Kidney Development and Function in the Fetus
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Te2, Part Iii
TERMINOLOGIA EMBRYOLOGICA Second Edition International Embryological Terminology FIPAT The Federative International Programme for Anatomical Terminology A programme of the International Federation of Associations of Anatomists (IFAA) TE2, PART III Contents Caput V: Organogenesis Chapter 5: Organogenesis (continued) Systema respiratorium Respiratory system Systema urinarium Urinary system Systemata genitalia Genital systems Coeloma Coelom Glandulae endocrinae Endocrine glands Systema cardiovasculare Cardiovascular system Systema lymphoideum Lymphoid system Bibliographic Reference Citation: FIPAT. Terminologia Embryologica. 2nd ed. FIPAT.library.dal.ca. Federative International Programme for Anatomical Terminology, February 2017 Published pending approval by the General Assembly at the next Congress of IFAA (2019) Creative Commons License: The publication of Terminologia Embryologica is under a Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) license The individual terms in this terminology are within the public domain. Statements about terms being part of this international standard terminology should use the above bibliographic reference to cite this terminology. The unaltered PDF files of this terminology may be freely copied and distributed by users. IFAA member societies are authorized to publish translations of this terminology. Authors of other works that might be considered derivative should write to the Chair of FIPAT for permission to publish a derivative work. Caput V: ORGANOGENESIS Chapter 5: ORGANOGENESIS -
Structure of Pronephros and Development of Mesonephric Kidney in Larvae of Russian Sturgeon, Acipenser Gueldenstaedtii Brandt (Acipenseridae)
Zoologica5 PRONEPHROS Poloniae-AND (2012)-MESONEPHRIC 57/1-4: 5-20-KIDNEY-IN-LARVAE-OF-A.-GUELDENSTAEDTII 5 DOI: 10.2478/v10049-012-0001-6 STRUCTURE OF PRONEPHROS AND DEVELOPMENT OF MESONEPHRIC KIDNEY IN LARVAE OF RUSSIAN STURGEON, ACIPENSER GUELDENSTAEDTII BRANDT (ACIPENSERIDAE) L.S. KRAYUSHKINA*1, A.A. GERASIMOV1, A.A. KIRSANOV1, M.V. MOSYAGINA1, A. OGORZA£EK2 1Department of Ichthyology and Hydrobiology, St. Petersburg State University, 16-th Line 29, 199178, St. Petersburg, Russia, [email protected] 2 Department of Animal Developmental Biology, Zoological Institute, University of Wroclaw, Sienkiewicza 21, 50-335 Wroclaw, Poland. *Corresponding author Abstract. The structure of the pronephros and development of mesonephric kidney in Russian sturgeon larvae, Acipenser gueldenstaedtii Brandt at different stages of early postembryonic development (from hatching to 14 days), were studied with histological and electronic microscopy methods. The larval pronephros is represented by the system of bilaterally located pronephric tubules with ciliated nephrostomes and funnels and exog- enous single glomus, which is not integrated directly into pronephric tubules and located in the pronephric chamber. The glomus is positioned below the dorsal aorta and vascular- ized by its capillaries. The glomus has the same features of the thin structure that are typical of and necessary for the function of a filtering organ. The structure of the prone- phros in acipenserids is discussed and compared with teleosts and amphibians. Histogen- esis of the mesonephric kidney is observed during the period of pronephros functioning; it is complete by the time the larvae transfer to exogenous feeding. At this moment, the pronephros undergoes significant structural degradation. -
Essential Roles of Inhibin Beta a in Mouse Epididymal Coiling
Essential roles of inhibin beta A in mouse epididymal coiling Jessica Tomaszewski*, Avenel Joseph†, Denise Archambeault†, and Humphrey Hung-Chang Yao†‡ *Department of Biology, School of Integrative Biology, and †Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana–Champaign, Urbana, IL 61802 Edited by Jean D. Wilson, University of Texas Southwestern Medical Center, Dallas, TX, and approved May 29, 2007 (received for review April 13, 2007) Testis-derived testosterone has been recognized as the key factor appear to be indirect via a mesenchyme-derived regulator(s). When for morphogenesis of the Wolffian duct, the precursor of several the upper Wolffian duct epithelium (the future epididymis) was male reproductive tract structures. Evidence supports that testos- grafted onto the lower Wolffian duct mesenchyme (the future terone is required for the maintenance of the Wolffian duct via its seminal vesicle), the epithelium underwent seminal vesicle mor- action on the mesenchyme. However, it remains uncertain how phogenesis and expressed markers specific for seminal vesicle testosterone alone is able to facilitate formation of regionally epithelium instead of those for epididymal epithelium (10). This specific structures such as the epididymis, vas deferens, and sem- inductive ability of Wolffian duct mesenchyme was also found in the inal vesicle from a straight Wolffian duct. In this study, we iden- prostate, providing further support that AR in the mesenchyme is tified inhibin beta A (or Inhba) as a regional paracrine factor in necessary to dictate androgenic actions of the epithelium (11). mouse mesonephroi that controls coiling of the epithelium in the Furthermore, when the epithelium from the AR-deficient testicular anterior Wolffian duct, the future epididymis. -
Stem Cells in the Embryonic Kidney R Nishinakamura1
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector http://www.kidney-international.org mini review & 2008 International Society of Nephrology Stem cells in the embryonic kidney R Nishinakamura1 1Division of Integrative Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Kumamoto, Japan The mammalian kidney, the metanephros, is formed by a STRATEGY TOWARD KIDNEY RECONSTITUTION USING reciprocally inductive interaction between two precursor PROGENITOR CELLS tissues, the metanephric mesenchyme and the ureteric bud. Stem cells are defined by two criteria: self-renewal and The ureteric bud induces the metanephric mesenchyme to multipotency. Few reports in the kidney field have addressed differentiate into the epithelia of glomeruli and renal tubules. both of these criteria at a clonal level, so it is better to use the Multipotent renal progenitors that form colonies upon Wnt4 term ‘progenitor’ rather than ‘stem cells.’ In this review, renal stimulation and strongly express Sall1 exist in the progenitors in the embryonic kidney, not those in the adult metanephric mesenchyme; these cells can partially kidney, from the viewpoint of developmental biology and reconstitute a three-dimensional structure in an organ stem/progenitor cell biology will be discussed. To generate culture setting. Six2 maintains this mesenchymal progenitor multiple cell lineages for kidney regeneration, the identifica- population by opposing Wnt4-mediated epithelialization. tion of renal progenitors is a prerequisite. Furthermore, there Upon epithelial tube formation, Notch2 is required for the exist three obstacles to be overcome: (1) derivation of the differentiation of proximal nephron structures (podocyte and renal progenitors; (2) expansion of the renal progenitors; and proximal tubules). -
Development of the Urogenital System of the Dog
DEVELOPMENT OF THE UROGENITAL SYSTEM OF THE DOG MAJID AHMED AL-RADHAWI LICENCE, Higher Teachers' Training College, Baghdad, Iraq, 1954 A. THESIS submitted in partial fulfillment of the requirements for the degree MASTER OF SCIENCE Department of Zoology KANSAS STATE COLLEGE OF AGRICULTURE AND APPLIED SCIENCE 1958 LD C-2- TABLE OF CONTENTS INTRODUCTION AND HEVIEW OF LITERATURE 1 MATERIALS AND METHODS 3 OBSERVATIONS 5 Group I, Embryos from 8-16 Somites 5 Group II, Embryos from 17-26 Somites 10 Group III, Embryos from 27-29 Somites 12 Group 17, Embryos from 34-41 Somites 15 Group V , Embryos from 41-53 Somites 18 Subgroup A, Embryos from 41-<7 Somites 18 Subgroup B, Embryos from 4-7-53 Somites 20 Group VI, Embryos Showing Indifferent Gonad 22 Group VII, Embryos with Differentiatle Gonad 24 Subgroup A, Embryos with Seoondarily Divertioulated Pelvis ... 25 Subgroup B, Embryos with the Anlagen of the Uriniferous Tubules . 26 Subgroup C, Embryos with Advanced Gonad 27 DISCUSSION AND GENERAL CONSIDERATION 27 Formation of the Kidney .... 27 The Pronephros 31 The Mesonephros 35 The Metanephros 38 The Ureter 39 The Urogenital Sinus 4.0 The Mullerian Duot 40 The Gonad 41 1 iii TABLE OF CONTENTS The Genital Ridge Stage 41 The Indifferent Stage , 41 The Determining Stage, The Testes . 42 The Ovary 42 SUMMARI , 42 ACKNOWLEDGMENTS 46 LITERATURE CITED 47 APJENDEC 51 j INTRODUCTION AND REVIEW OF LITERATURE Nephrogenesis has been adequately described in only a few mammals, Buchanan and Fraser (1918), Fraser (1920), and MoCrady (1938) studied nephrogenesis in marsupials. Keibel (1903) reported on studies on Echidna Van der Strioht (1913) on the batj Torrey (1943) on the rat; and Bonnet (1888) and Davles and Davies (1950) on the sheep. -
Secreted Molecules in Metanephric Induction
J Am Soc Nephrol 11: S116–S119, 2000 Secreted Molecules in Metanephric Induction THOMAS J. CARROLL and ANDREW P. McMAHON Department of Molecular and Cellular Biology, Biological Laboratories, Harvard University, Cambridge, Massachusetts. Abstract. Nearly 50 yr ago, Clifford Grobstein made the ob- the classic model of metanephric induction. The studies of the servation that the ureteric bud induced the nephrogenic mes- classic ureteric inducer performed to date have most likely enchyme to undergo tubulogenesis. Since that discovery, sci- been characterizations of a mesenchyme-specific inducer, entists have attempted to characterize the molecular nature of Wnt-4, and its role in tubulogenesis. Ureteric induction most the inducer. To date, no single molecule that is both necessary likely involves a series of distinct events that provide prolif- and sufficient for nephric induction has been identified. Be- erative, survival, and condensation signals to the mesenchyme, cause of recent insights regarding the role of several secreted integrating the growth of the ureteric system with tubulogen- molecules in tubulogenesis, it has become necessary to revise esis. The developmental biologic processes of the kidney have been logenesis. The conclusion drawn from this discovery was that the subject of intense study for more than 100 yr (for review, the ureteric bud induces tubulogenesis within the surrounding see reference (1). All three vertebrate kidney types (pro- mesenchyme. During further investigation, it was discovered nephros, mesonephros, and metanephros) are derivatives of a that a number of tissues, including, most notably, a dorsal region of the embryo known as the intermediate mesoderm. In portion of the embryonic spinal cord, are able to substitute for mice, a portion of the mesonephric duct, known as the meta- the ureter in this inductive interaction. -
Glomus Specification and Induction in Xenopus
Development 126, 5847-5856 (1999) 5847 Printed in Great Britain © The Company of Biologists Limited 1999 DEV6378 The specification and growth factor inducibility of the pronephric glomus in Xenopus laevis Hannah C. Brennan, Sarbjit Nijjar and Elizabeth A. Jones* Cell and Molecular Development Group, Department of Biological Sciences, Warwick University, Coventry, CV4 7AL, UK *Author for correspondence (e-mail: [email protected]) Accepted 23 September; published on WWW 24 November 1999 SUMMARY We report a study on the specification of the glomus, the Furthermore, we have analysed the growth factor filtration device of the amphibian pronephric kidney, using inducibility of the glomus in the presence or absence of an explant culturing strategy in Xenopus laevis. Explants of retinoic acid (RA) by RT-PCR. We define for the first time presumptive pronephric mesoderm were dissected from the conditions under which these growth factors induce embryos of mid-gastrula to swimming tadpole stages. These glomus tissue in animal cap tissue. Activin together with explants were cultured within ectodermal wraps and high concentrations of RA can induce glomus tissue from analysed by RT-PCR for the presence of the Wilm’s Tumour- animal cap ectoderm. Unlike the pronephric tubules, the 1 gene, xWT1, a marker specific for the glomus at the stages glomus can also be induced by FGF and RA. analysed, together with other mesodermal markers. We show that the glomus is specified at stage 12.5, the same stage at which pronephric tubules are specified. We have previously shown that pronephric duct is specified somewhat later, at stage 14. -
ROBO2 Restricts the Nephrogenic Field and Regulates Wolffian Duct–Nephrogenic Cord Separation
Developmental Biology 404 (2015) 88–102 Contents lists available at ScienceDirect Developmental Biology journal homepage: www.elsevier.com/locate/developmentalbiology ROBO2 restricts the nephrogenic field and regulates Wolffian duct–nephrogenic cord separation Elanor N. Wainwright 1, Dagmar Wilhelm 2, Alexander N. Combes 3, Melissa H. Little 4, Peter Koopman n Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia article info abstract Article history: ROBO2 plays a key role in regulating ureteric bud (UB) formation in the embryo, with mutations in Received 7 April 2015 humans and mice leading to supernumerary kidneys. Previous studies have established that the number Received in revised form and position of UB outgrowths is determined by the domain of metanephric mesenchymal Gdnf ex- 28 May 2015 pression, which is expanded anteriorly in Robo2 mouse mutants. To clarify how this phenotype arises, we Accepted 30 May 2015 used high-resolution 3D imaging to reveal an increase in the number of nephrogenic cord cells, leading Available online 23 June 2015 to extension of the metanephric mesenchyme field in Robo2-null mouse embryos. Ex vivo experiments Keywords: suggested a dependence of this effect on proliferative signals from the Wolffian duct. Loss of Robo2 Kidney resulted in a failure of the normal separation of the mesenchyme from the Wolffian duct/ureteric epi- Wolffian duct thelium, suggesting that aberrant juxtaposition of these two compartments in Robo2-null mice exposes Ureteric bud the mesenchyme to abnormally high levels of proliferative stimuli. Our data suggest a new model in Nephrogenic cord Mouse which SLIT-ROBO signalling acts not by attenuating Gdnf expression or activity, but instead by limiting epithelial/mesenchymal interactions in the nascent metanephros and restricting the extent of the ne- phrogenic field. -
Urinary System Intermediate Mesoderm
Urinary System Intermediate mesoderm lateral mesoderm: somite ectoderm neural NOTE: Intermediate mesoderm splanchnic groove somatic is situated between somites and lateral mesoderm (somatic and splanchnic mesoderm bordering the coelom). All mesoderm is derived from the primary mesen- intermediate mesoderm endoderm chyme that migrated through the notochord coelom (becomes urogenital ridge) primitive streak. Intermediate mesoderm (plus adjacent mesothelium lining the coelom) forms a urogenital ridge, which consists of a laterally-positioned nephrogenic cord (that forms kidneys & ureter) and a medially-positioned gonadal ridge (for ovary/testis & female/male genital tract formation). Thus urinary & genital systems have a common embryonic origin; also, they share common ducts. NOTE: Urine production essentially requires an increased capillary surface area (glomeruli), epithelial tubules to collect plasma filtrate and extract desirable constituents, and a duct system to convey urine away from the body. Kidneys Bilateraly, three kid- mesonephric duct neys develop from the neph- metanephros pronephros rogenic cord. They develop mesonephric tubules chronologically in cranial- mesonephros caudal sequence, and are designated pro—, meso—, Nephrogenic Cord (left) and meta—, respectively. cloaca The pronephros and mesonephros develop similarly: the nephrogenic cord undergoes seg- mentation, segments become tubules, tubules drain into a duct & eventually tubules disintegrate. spinal ganglion 1] Pronephros—consists of (7-8) primitive tubules and a pronephric duct that grows caudally and terminates in the cloaca. The tubules soon degenerate, but the pronephric duct persists as the neural tube mesonephric duct. (The pronephros is not functional, somite except in sheep.) notochord mesonephric NOTE tubule The mesonephros is the functional kidney for fish and am- aorta phibians. The metanephros is the functional kidney body of reptiles, birds, & mammals. -
Embryology of the Kidney Rizaldy Paz Scott | Yoshiro Maezawa | Jordan Kreidberg | Susan E
1 Embryology of the Kidney Rizaldy Paz Scott | Yoshiro Maezawa | Jordan Kreidberg | Susan E. Quaggin CHAPTER OUTLINE MAMMALIAN KIDNEY DEVELOPMENT, 2 MOLECULAR GENETICS OF MODEL SYSTEMS TO STUDY KIDNEY NEPHROGENESIS, 22 DEVELOPMENT, 8 GENETIC ANALYSIS OF MAMMALIAN KIDNEY DEVELOPMENT, 15 KEY POINTS • The development of the kidney relies on reciprocal signaling and inductive interactions between neighboring cells. • Epithelial cells that comprise the tubular structures of the kidney are derived from two distinct cell lineages: the ureteric epithelia lineage that branches and gives rise to collecting ducts and the nephrogenic mesenchyme lineage that undergoes mesenchyme to epithelial transition to form connecting tubules, distal tubules, the loop of Henle, proximal tubules, parietal epithelial cells, and podocytes. • Nephrogenesis and nephron endowment requires an epigenetically regulated balance between nephron progenitor self-renewal and epithelial differentiation. • The timing of incorporation of nephron progenitor cells into nascent nephrons predicts their positional identity within the highly patterned mature nephron. • Stromal cells and their derivatives coregulate ureteric branching morphogenesis, nephrogenesis, and vascular development. • Endothelial cells track the development of the ureteric epithelia and establish the renal vasculature through a combination of vasculogenic and angiogenic processes. • Collecting duct epithelia have an inherent plasticity enabling them to switch between principal and intercalated cell identities. MAMMALIAN KIDNEY DEVELOPMENT The filtration function of the kidneys is accomplished by basic units called nephrons (Fig. 1.1). Humans on average have 1 million nephrons per adult kidney but the range of ANATOMIC OVERVIEW OF THE 4 MAMMALIAN KIDNEY total nephrons is highly variable across human populations. Each mouse kidney may contain up to 12,000–16,000 nephrons The kidney is a sophisticated, highly vascularized organ that depending on the strain.5 This wide range in nephron number plays a central role in overall body homeostasis. -
Urinary System
OUTLINE 27.1 General Structure and Functions of the Urinary System 818 27.2 Kidneys 820 27 27.2a Gross and Sectional Anatomy of the Kidney 820 27.2b Blood Supply to the Kidney 821 27.2c Nephrons 824 27.2d How Tubular Fluid Becomes Urine 828 27.2e Juxtaglomerular Apparatus 828 Urinary 27.2f Innervation of the Kidney 828 27.3 Urinary Tract 829 27.3a Ureters 829 27.3b Urinary Bladder 830 System 27.3c Urethra 833 27.4 Aging and the Urinary System 834 27.5 Development of the Urinary System 835 27.5a Kidney and Ureter Development 835 27.5b Urinary Bladder and Urethra Development 835 MODULE 13: URINARY SYSTEM mck78097_ch27_817-841.indd 817 2/25/11 2:24 PM 818 Chapter Twenty-Seven Urinary System n the course of carrying out their specific functions, the cells Besides removing waste products from the bloodstream, the uri- I of all body systems produce waste products, and these waste nary system performs many other functions, including the following: products end up in the bloodstream. In this case, the bloodstream is ■ Storage of urine. Urine is produced continuously, but analogous to a river that supplies drinking water to a nearby town. it would be quite inconvenient if we were constantly The river water may become polluted with sediment, animal waste, excreting urine. The urinary bladder is an expandable, and motorboat fuel—but the town has a water treatment plant that muscular sac that can store as much as 1 liter of urine. removes these waste products and makes the water safe to drink. -
Nephric Lineage Specification by Pax2 and Pax8
Downloaded from genesdev.cshlp.org on September 28, 2021 - Published by Cold Spring Harbor Laboratory Press Nephric lineage specification by Pax2 and Pax8 Maxime Bouchard, Abdallah Souabni, Markus Mandler, Annette Neubüser, and Meinrad Busslinger1 Research Institute of Molecular Pathology, Vienna Biocenter, A-1030 Vienna, Austria The mammalian kidney develops in three successive steps from the initial pronephros via the mesonephros to the adult metanephros. Although the nephric lineage is specified during pronephros induction, no single regulator, including the transcription factor Pax2 or Pax8, has yet been identified to control this initial phase of kidney development. In this paper, we demonstrate that mouse embryos lacking both Pax2 and Pax8 are unable to form the pronephros or any later nephric structures. In these double-mutant embryos, the intermediate mesoderm does not undergo the mesenchymal-epithelial transitions required for nephric duct formation, fails to initiate the kidney-specific expression of Lim1and c -Ret, and is lost by apoptosis 1d after failed pronephric induction. Conversely, retroviral misexpression of Pax2 was sufficient to induce ectopic nephric structures in the intermediate mesoderm and genital ridge of chick embryos. Together, these data identify Pax2 and Pax8 as critical regulators that specify the nephric lineage. [Keywords: Pax2;Pax8;genetic redundancy;kidney development;mesenchymal-epithelial transition;lineage specification] Received June 28, 2002;revised version accepted September 20, 2002. Kidney development in mammals and birds proceeds in development (for review, see Kuure et al. 2000;Davies three successive steps that are all characterized by the and Brändli 2002). The majority of these genes are essen- mesenchymal-to-epithelial transformation of intermedi- tial for proper morphogenesis of the metanephros with ate mesoderm cells.