Email [email protected] Description Q9BPY3 Fri May 25 09:51:07 BST Date 2012 Unique Job 56aab5aca28c377d ID

Detailed template

information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

Fold:DHS-like NAD/FAD-binding domain 1 d1yc5a1 Alignment 98.7 20 Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators

Fold:DHS-like NAD/FAD-binding domain 2 d1q1aa_ Alignment 98.6 19 Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators

Fold:DHS-like NAD/FAD-binding domain 3 d2b4ya1 Alignment 98.5 25 Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators

Fold:DHS-like NAD/FAD-binding domain 4 d1m2ka_ Alignment 98.4 16 Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators

PDB header: 5 c3glsC_ Alignment 98.3 19 Chain: C: PDB Molecule:nad-dependent deacetylase sirtuin-3, PDBTitle: crystal structure of human sirt3

Fold:DHS-like NAD/FAD-binding domain 6 d1j8fa_ Alignment 98.3 18 Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators

PDB header:hydrolase 7 c3k35D_ Alignment 98.3 15 Chain: D: PDB Molecule:nad-dependent deacetylase sirtuin-6; PDBTitle: crystal structure of human sirt6

Fold:DHS-like NAD/FAD-binding domain 8 d1ma3a_ Alignment 98.2 21 Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators

PDB header:transcription Chain: A: PDB Molecule:transcriptional regulatory protein sir2 9 c3jwpA_ Alignment 98.2 22 homologue; PDBTitle: crystal structure of plasmodium falciparum sir2a (pf13_0152) in2 complex with amp

PDB header:hydrolase 10 c2hjhB_ Alignment 98.2 17 Chain: B: PDB Molecule:nad-dependent histone deacetylase sir2; PDBTitle: crystal structure of the sir2 deacetylase

Fold:DHS-like NAD/FAD-binding domain 11 d1s5pa_ Alignment 98.1 19 Superfamily:DHS-like NAD/FAD-binding domain Family:Sir2 family of transcriptional regulators PDB header:hydrolase 12 c3pkiF_ Alignment 98.0 18 Chain: F: PDB Molecule:nad-dependent deacetylase sirtuin-6; PDBTitle: human sirt6 crystal structure in complex with adp ribose

PDB header:hydrolase Chain: A: PDB Molecule:hst2 protein; 13 c1q14A_ 97.7 26 Alignment PDBTitle: structure and autoregulation of the yeast hst2 homolog of sir2

PDB header: 14 c1zfnA_ Alignment 58.0 14 Chain: A: PDB Molecule:adenylyltransferase thif; PDBTitle: structural analysis of escherichia coli thif

PDB header: Chain: A: PDB Molecule:putative tagatose-6-phosphate ketose/aldose isomerase; 15 c3odpA_ 54.9 22 Alignment PDBTitle: crystal structure of a putative tagatose-6-phosphate ketose/aldose2 isomerase (nt01cx_0292) from clostridium novyi nt at 2.35 a3 resolution

PDB header: Chain: A: PDB Molecule:l-amino acid oxidase; 16 c1f8sA_ Alignment 52.9 27 PDBTitle: crystal structure of l-amino acid oxidase from calloselasma2 rhodostoma, complexed with three molecules of o- aminobenzoate.

Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent 17 d1booa_ 52.8 30 Alignment methyltransferases Family:Type II DNA methylase

PDB header: 18 c3pg6D_ Alignment 52.0 18 Chain: D: PDB Molecule:e3 ubiquitin-protein ligase dtx3l; PDBTitle: the carboxyl terminal domain of human deltex 3-like

PDB header:isomerase Chain: B: PDB Molecule:putative tagatose-6-phosphate ketose/aldose isomerase; 19 c3i0zB_ 51.6 27 Alignment PDBTitle: crystal structure of putative putative tagatose-6- phosphate2 ketose/aldose isomerase (np_344614.1) from streptococcus pneumoniae3 tigr4 at 1.70 a resolution

Fold:PSTPO5379-like 20 d2pifa1 Alignment 49.0 13 Superfamily:PSTPO5379-like Family:PSTPO5379-like

PDB header:isomerase Chain: D: PDB Molecule:putative fructose-aminoacid-6-phosphate 21 c3euaD_ Alignment not modelled 47.5 26 deglycase; PDBTitle: crystal structure of a putative phosphosugar isomerase (bsu32610) from2 bacillus subtilis at 1.90 a resolution Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent 22 d1eg2a_ not modelled 45.8 39 Alignment methyltransferases Family:Type II DNA methylase Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent 23 d1g60a_ not modelled 45.3 42 Alignment methyltransferases Family:Type II DNA methylase PDB header:isomerase Chain: A: PDB Molecule:putative tagatose-6-phosphate 24 c3c3jA_ Alignment not modelled 44.4 20 ketose/aldose isomerase; PDBTitle: crystal structure of tagatose-6-phosphate ketose/aldose isomerase from2 escherichia coli PDB header:transferase Chain: A: PDB Molecule:modification methylase rsri; 25 c1nw6A_ not modelled 43.3 39 Alignment PDBTitle: structure of the beta class n6-adenine dna methyltransferase rsri2 bound to sinefungin PDB header:isomerase Chain: A: PDB Molecule:putative phosphosugar ; 26 c3fkjA_ not modelled 42.5 20 Alignment PDBTitle: crystal structure of a putative phosphosugar isomerase (stm_0572) from2 salmonella typhimurium lt2 at 2.12 a resolution PDB header:transferase Chain: A: PDB Molecule:pts system, cellobiose-specific iib component (cela); 27 c2l2qA_ not modelled 38.0 29 Alignment PDBTitle: solution structure of cellobiose-specific phosphotransferase iib2 component protein from borrelia burgdorferi Fold:FAD/NAD(P)-binding domain 28 d2iida1 Alignment not modelled 37.3 27 Superfamily:FAD/NAD(P)-binding domain Family:FAD-linked reductases, N-terminal domain PDB header:hydrolase Chain: B: PDB Molecule:alkaline phosphatase; 29 c2iucB_ not modelled 37.2 29 Alignment PDBTitle: structure of alkaline phosphatase from the antarctic2 bacterium tab5 Fold:Alkaline phosphatase-like 30 d1zeda1 Alignment not modelled 35.6 12 Superfamily:Alkaline phosphatase-like Family:Alkaline phosphatase PDB header:transferase Chain: B: PDB Molecule:putative modification methylase; 31 c2zifB_ Alignment not modelled 35.5 26 PDBTitle: crystal structure of ttha0409, putative dna modification2 methylase from thermus thermophilus hb8- complexed with s-3 adenosyl-l-methionine PDB header:hydrolase 32 c1ew2A_ Alignment not modelled 35.4 12 Chain: A: PDB Molecule:phosphatase; PDBTitle: crystal structure of a human phosphatase

Fold:Phosphotyrosine protein phosphatases I-like 33 d1iiba_ Alignment not modelled 33.0 21 Superfamily:PTS system IIB component-like Family:PTS system, Lactose/Cellobiose specific IIB subunit

PDB header:oxidoreductase 34 c2hkoA_ Alignment not modelled 31.1 57 Chain: A: PDB Molecule:lysine-specific histone demethylase 1; PDBTitle: crystal structure of lsd1

Fold:Alkaline phosphatase-like 35 d1y6va1 Alignment not modelled 29.7 28 Superfamily:Alkaline phosphatase-like Family:Alkaline phosphatase PDB header:transferase Chain: A: PDB Molecule:pts system, lactose-specific iibc components; 36 c3nbmA_ not modelled 29.6 18 Alignment PDBTitle: the lactose-specific iib component domain structure of the2 phosphoenolpyruvate:carbohydrate phosphotransferase system (pts) from3 streptococcus pneumoniae. PDB header:transferase Chain: A: PDB Molecule:possible 3-mercaptopyruvate 37 c1okgA_ Alignment not modelled 28.4 10 sulfurtransferase; PDBTitle: 3-mercaptopyruvate sulfurtransferase from leishmania major Fold:Alkaline phosphatase-like 38 d1k7ha_ Alignment not modelled 24.7 22 Superfamily:Alkaline phosphatase-like Family:Alkaline phosphatase PDB header:transferase Chain: A: PDB Molecule:histone-arginine methyltransferase carm1; 39 c3b3jA_ not modelled 24.3 23 Alignment PDBTitle: the 2.55 a crystal structure of the apo catalytic domain of2 coactivator-associated arginine methyl transferase i(carm1:28- 507,3 residues 28-146 and 479-507 not ordered) PDB header:isomerase 40 c1i8tB_ Alignment not modelled 24.2 22 Chain: B: PDB Molecule:udp-galactopyranose mutase; PDBTitle: strcuture of udp-galactopyranose mutase from e.coli PDB header:ligase Chain: A: PDB Molecule:udp-n-acetylmuramate-alanine ligase 41 c1j6uA_ Alignment not modelled 23.9 12 murc; PDBTitle: crystal structure of udp-n-acetylmuramate-alanine ligase2 murc (tm0231) from thermotoga maritima at 2.3 a resolution PDB header:isomerase Chain: A: PDB Molecule:putative phosphosugar isomerase; 42 c3hbaA_ Alignment not modelled 23.1 22 PDBTitle: crystal structure of a putative phosphosugar isomerase (sden_2705)2 from shewanella denitrificans os217 at 2.00 a resolution PDB header:isomerase Chain: I: PDB Molecule:udp-galactopyranose mutase; 43 c3hdqI_ not modelled 22.9 33 Alignment PDBTitle: crystal structure of udp-galactopyranose mutase (oxidized2 form) in complex with Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent 44 d1f3la_ not modelled 22.6 17 Alignment methyltransferases Family:Arginine methyltransferase Fold:MurD-like peptide , peptide-binding domain 45 d1p3da2 Alignment not modelled 22.4 19 Superfamily:MurD-like peptide ligases, peptide-binding domain Family:MurCDEF C-terminal domain

Fold:Activating of the ubiquitin-like proteins 46 d1jw9b_ Alignment not modelled 21.7 18 Superfamily:Activating enzymes of the ubiquitin-like proteins Family:Molybdenum biosynthesis protein MoeB PDB header:oxidoreductase Chain: A: PDB Molecule:l-glutamate oxidase; 47 c2e1mA_ not modelled 21.2 30 Alignment PDBTitle: crystal structure of l-glutamate oxidase from streptomyces sp. x-119-6 PDB header:oxygenase Chain: A: PDB Molecule:phenylacetone monooxygenase; 48 c1w4xA_ not modelled 20.8 50 Alignment PDBTitle: phenylacetone monooxygenase, a baeyer-villiger2 monooxygenase PDB header:sugar binding protein Chain: A: PDB Molecule:putative sugar binding protein; 49 c3knzA_ Alignment not modelled 20.3 17 PDBTitle: crystal structure of putative sugar binding protein (np_459565.1) from2 salmonella typhimurium lt2 at 2.50 a resolution PDB header:isomerase Chain: A: PDB Molecule:udp-galactopyranose mutase; 50 c2bi8A_ not modelled 19.5 44 Alignment PDBTitle: udp-galactopyranose mutase from klebsiella pneumoniae with2 reduced fad PDB header:oxidoreductase Chain: C: PDB Molecule:glycerol-3-phosphate dehydrogenase; 51 c1yj8C_ not modelled 18.9 30 Alignment PDBTitle: initial structural analysis of plasmodium falciparum glycerol-3-2 phosphate dehydrogenase PDB header:isomerase Chain: A: PDB Molecule:putative aminooxidase; 52 c2b9yA_ not modelled 17.8 31 Alignment PDBTitle: crystal structure of cla-producing fatty acid isomerase2 from p. acnes Fold:FAD/NAD(P)-binding domain 53 d2dw4a2 Alignment not modelled 17.6 56 Superfamily:FAD/NAD(P)-binding domain Family:FAD-linked reductases, N-terminal domain

Fold:Nucleotide-binding domain 54 d1i8ta1 Alignment not modelled 17.4 22 Superfamily:Nucleotide-binding domain Family:UDP-galactopyranose mutase, N-terminal domain PDB header:isomerase Chain: B: PDB Molecule:udp-galactopyranose mutase; 55 c1v0jB_ not modelled 17.2 33 Alignment PDBTitle: udp-galactopyranose mutase from mycobacterium tuberculosis Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain 56 d2gv8a1 not modelled 16.5 44 Alignment Family:FAD/NAD-linked reductases, N-terminal and central domains PDB header:biosynthetic protein, transferase Chain: A: PDB Molecule:putative uncharacterized protein; 57 c3fpjA_ not modelled 16.3 17 Alignment PDBTitle: crystal structure of e81q mutant of mtnas in complex with s-2 adenosylmethionine Fold:Thioredoxin fold 58 d2dlxa1 Alignment not modelled 16.2 16 Superfamily:Thioredoxin-like Family:UAS domain

Fold:SIS domain 59 d1jeoa_ Alignment not modelled 16.2 18 Superfamily:SIS domain Family:mono-SIS domain

Fold:MurD-like peptide ligases, peptide-binding domain 60 d1j6ua2 Alignment not modelled 16.0 21 Superfamily:MurD-like peptide ligases, peptide-binding domain Family:MurCDEF C-terminal domain PDB header:transferase Chain: B: PDB Molecule:putative thiosulfate sulfurtransferase; 61 c3aaxB_ Alignment not modelled 15.9 13 PDBTitle: crystal structure of probable thiosulfate sulfurtransferase2 cysa3 (rv3117) from mycobacterium tuberculosis: monoclinic3 form Fold:FAD/NAD(P)-binding domain 62 d1reoa1 Alignment not modelled 15.8 40 Superfamily:FAD/NAD(P)-binding domain Family:FAD-linked reductases, N-terminal domain Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain 63 d2gv8a2 not modelled 15.8 60 Alignment Family:FAD/NAD-linked reductases, N-terminal and central domains Fold:NAD(P)-binding Rossmann-fold domains 64 d2csua1 Alignment not modelled 15.5 18 Superfamily:NAD(P)-binding Rossmann-fold domains Family:CoA-binding domain

Fold:FAD/NAD(P)-binding domain 65 d1d5ta1 Alignment not modelled 15.4 56 Superfamily:FAD/NAD(P)-binding domain Family:GDI-like N domain PDB header:ligase Chain: A: PDB Molecule:udp-n-acetylmuramate:l-alanyl-gamma-d- glutamayl-medo- 66 c3mvnA_ not modelled 14.8 15 Alignment PDBTitle: crystal structure of a domain from a putative udp-n- acetylmuramate:l-2 alanyl-gamma-d-glutamayl-medo- diaminopimelate ligase from haemophilus3 ducreyi 35000hp PDB header:oxidoreductase Chain: A: PDB Molecule:polyamine oxidase fms1; 67 c3bnuA_ Alignment not modelled 14.7 56 PDBTitle: crystal structure of polyamine oxidase fms1 from2 saccharomyces cerevisiae in complex with bis-(3s,3's)-3 methylated spermine Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain 68 d1w4xa1 not modelled 14.5 67 Alignment Family:FAD/NAD-linked reductases, N-terminal and central domains Fold:Nucleotide-binding domain 69 d2bi7a1 Alignment not modelled 14.3 44 Superfamily:Nucleotide-binding domain Family:UDP-galactopyranose mutase, N-terminal domain PDB header:oxidoreductase Chain: D: PDB Molecule: n; 70 c2vvlD_ not modelled 14.2 56 Alignment PDBTitle: the structure of mao-n-d3, a variant of monoamine oxidase2 from aspergillus niger. PDB header:oxidoreductase Chain: B: PDB Molecule:6-hydroxy-l-nicotine oxidase; 71 c3k7tB_ not modelled 13.7 44 Alignment PDBTitle: crystal structure of apo-form 6-hydroxy-l-nicotine oxidase,2 crystal form p3121 Fold:MurD-like peptide ligases, peptide-binding domain 72 d2jfga2 Alignment not modelled 13.7 16 Superfamily:MurD-like peptide ligases, peptide-binding domain Family:MurCDEF C-terminal domain

Fold:FAD/NAD(P)-binding domain 73 d2v5za1 Alignment not modelled 13.4 67 Superfamily:FAD/NAD(P)-binding domain Family:FAD-linked reductases, N-terminal domain

Fold:FAD/NAD(P)-binding domain 74 d2bcgg1 Alignment not modelled 13.3 67 Superfamily:FAD/NAD(P)-binding domain Family:GDI-like N domain Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent 75 d2fyta1 not modelled 13.2 17 Alignment methyltransferases Family:Arginine methyltransferase Fold:FAD/NAD(P)-binding domain 76 d2i0za1 Alignment not modelled 13.2 67 Superfamily:FAD/NAD(P)-binding domain Family:HI0933 N-terminal domain-like

Fold:FAD/NAD(P)-binding domain 77 d1b5qa1 Alignment not modelled 13.1 56 Superfamily:FAD/NAD(P)-binding domain Family:FAD-linked reductases, N-terminal domain PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease zc3h12a; 78 c3v33A_ not modelled 13.1 27 Alignment PDBTitle: crystal structure of mcpip1 conserved domain with zinc- finger motif PDB header:protein binding Chain: B: PDB Molecule:dna mismatch repair protein mlh1; 79 c3rbnB_ not modelled 13.0 33 Alignment PDBTitle: crystal structure of mutl protein homolog 1 isoform 1 [homo sapiens] Fold:DNA/RNA-binding 3-helical bundle 80 d1hsta_ Alignment not modelled 13.0 14 Superfamily:"Winged helix" DNA-binding domain Family:Linker histone H1/H5 PDB header:oxidoreductase Chain: A: PDB Molecule:protoporphyrinogen oxidase; 81 c3lovA_ Alignment not modelled 13.0 33 PDBTitle: crystal structure of putative protoporphyrinogen oxidase2 (yp_001813199.1) from exiguobacterium sp. 255-15 at 2.06 a resolution PDB header:oxidoreductase Chain: A: PDB Molecule:polyamine oxidase; 82 c1h83A_ not modelled 12.8 56 Alignment PDBTitle: structure of polyamine oxidase in complex with2 1,8- diaminooctane PDB header:oxidoreductase Chain: B: PDB Molecule: [flavin-containing] b; 83 c1s3bB_ not modelled 12.7 67 Alignment PDBTitle: crystal structure of maob in complex with n-methyl-n-2 propargyl-1(r)-aminoindan Fold:Ribosomal protein S5 domain 2-like 84 d2cvea1 Alignment not modelled 12.6 22 Superfamily:Ribosomal protein S5 domain 2-like Family:YigZ N-terminal domain-like PDB header:oxidoreductase Chain: A: PDB Molecule:protoporphyrinogen oxidase, 85 c1sezA_ not modelled 12.6 67 Alignment mitochondrial; PDBTitle: crystal structure of protoporphyrinogen ix oxidase PDB header:oxidoreductase Chain: B: PDB Molecule:otemo; 86 c3uoyB_ not modelled 12.6 44 Alignment PDBTitle: crystal structure of otemo complex with fad and nadp (form 1) PDB header:oxidoreductase Chain: B: PDB Molecule:flavin-containing monooxygenase; 87 c2vq7B_ not modelled 12.5 33 Alignment PDBTitle: bacterial flavin-containing monooxygenase in complex with2 nadp: native data PDB header:de novo protein Chain: A: PDB Molecule:de novo designed protein, pfk fold; 88 c2lndA_ not modelled 12.3 19 Alignment PDBTitle: solution nmr structure of de novo designed protein, pfk fold,2 northeast structural genomics consortium target or134 Fold:FAD/NAD(P)-binding domain 89 d1o5wa1 Alignment not modelled 12.2 78 Superfamily:FAD/NAD(P)-binding domain Family:FAD-linked reductases, N-terminal domain PDB header:isomerase Chain: B: PDB Molecule:udp-galactopyranose mutase; 90 c3uteB_ not modelled 12.1 67 Alignment PDBTitle: crystal structure of aspergillus fumigatus udp galactopyranose mutase2 sulfate complex PDB header:oxidoreductase Chain: B: PDB Molecule:putrescine oxidase; 91 c2yg4B_ not modelled 12.1 44 Alignment PDBTitle: structure-based redesign of cofactor binding in putrescine2 oxidase: wild type bound to putrescine Fold:MurD-like peptide ligases, peptide-binding domain 92 d1e8ca2 Alignment not modelled 12.1 18 Superfamily:MurD-like peptide ligases, peptide-binding domain Family:MurCDEF C-terminal domain PDB header:oxidoreductase Chain: A: PDB Molecule:putrescine oxidase; 93 c3rhaA_ not modelled 11.8 44 Alignment PDBTitle: the crystal structure of oxidoreductase from arthrobacter aurescens Fold:FAD/NAD(P)-binding domain 94 d1vg0a1 Alignment not modelled 11.8 67 Superfamily:FAD/NAD(P)-binding domain Family:GDI-like N domain Fold:FAD/NAD(P)-binding domain Superfamily:FAD/NAD(P)-binding domain 95 d1w4xa2 not modelled 11.7 70 Alignment Family:FAD/NAD-linked reductases, N-terminal and central domains PDB header:hydrolase Chain: B: PDB Molecule:alkaline phosphatase; 96 c3e2dB_ not modelled 11.7 25 Alignment PDBTitle: the 1.4 a crystal structure of the large and cold-active2 vibrio sp. alkaline phosphatase PDB header:transferase/protein binding Chain: R: PDB Molecule:rab escort protein 1; 97 c1ltxR_ not modelled 11.7 67 Alignment PDBTitle: structure of rab escort protein-1 in complex with rab2 geranylgeranyl transferase and isoprenoid PDB header:transferase Chain: B: PDB Molecule:sis domain protein; 98 c2amlB_ not modelled 11.6 30 Alignment PDBTitle: crystal structure of lmo0035 protein (46906266) from listeria2 monocytogenes 4b f2365 at 1.50 a resolution PDB header:oxidoreductase 99 c3qj4A_ Alignment not modelled 11.6 44 Chain: A: PDB Molecule:renalase; PDBTitle: crystal structure of human renalase (isoform 1)