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Home , ADCY3, ADCY6, ATP1A2, ATP2B3, C1QBP, CACNG1

Supplementary Table 1: -Sensitive

Supplementary Table 1: Upregulated with Calcineurin (pages 1 -10)- genes that were significant by ANOVA as well as significantly increased in calcineurin- infected cells (Ad-aCaN) compared to 'infected control' (Ad-LacZ). Downregulated with Calcineurin (pages 10 - 17) as above except for direction of change. Columns: Probe Set- Affymetrix probe set identifier for RG-U34A microarray, Symbol (bold font- aCaN significantly different from both LacZ and Uninfected, normal font- aCaN different from LacZ) and Title- annotated information for above probe set (annotation downloaded June, 2004), ANOVA- p-value for 1-way Analysis of Variance, Uninfected, Ad-LacZ and Ad-aCaN- mean ± SEM expression for uninfected control, adenovirus mediated LacZ treated control, and adenovirus mediated calcineurin treated cultures respectively.

Upregulated with Calcineurin Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN rc_AI639448_at A5D3 A5D3 0.00005 713 ± 58 352 ± 54 831 ± 64 J05029_s_at Acadl acetyl-Coenzyme A , long-chain 0.00000 1105 ± 71 483 ± 46 863 ± 37 J05030_at Acads short chain acyl-coenzyme A dehydrogenase 0.01217 515 ± 40 367 ± 25 513 ± 37 D30647_at Acadvl acyl-Coenzyme A dehydrogenase, very long chain 0.00000 423 ± 21 191 ± 15 271 ± 16 rc_AA900769_s_at Acta2 alpha- 0.00246 2629 ± 331 2169 ± 264 4228 ± 466 AJ012603UTR#1_g_at Adam17 a disintegrin and domain 17 0.00000 435 ± 30 320 ± 49 711 ± 30 M55075_at Adcy3 adenylate 3 0.04669 1440 ± 95 1207 ± 84 1561 ± 99 L01115_at Adcy6 6 0.01117 372 ± 24 371 ± 19 467 ± 26 D14909_at Adcyap1r1 adenylate cyclase activating polypeptide 1 1 0.04816 353 ± 18 313 ± 23 393 ± 22 rc_AA943892_at Agt angiotensinogen 0.00027 703 ± 54 381 ± 37 527 ± 39 U41453_at Akap12 A (PRKA) anchor protein (gravin) 12 0.00008 370 ± 36 513 ± 25 627 ± 34 J03190_at Alas1 aminolevulinic 1 0.02469 767 ± 69 626 ± 50 828 ± 29 rc_AI172017_at Aldh2 2 0.00000 1141 ± 61 531 ± 31 694 ± 21 M73714_at Aldh3a2 aldehyde dehydrogenase family 3, subfamily A2 0.00538 571 ± 26 382 ± 43 525 ± 37 M60322_at Aldr1 Aldehyde 1 (low Km ) 0.00000 4596 ± 136 4890 ± 143 6605 ± 166 U89905_at Amacr alpha-methylacyl-CoA racemase 0.04540 580 ± 32 509 ± 33 620 ± 25 U90888_at Ampd3 Adenosine monophosphate deaminase 3 0.00075 79 ± 4 45 ± 11 89 ± 5 AF030089UTR#1_at Ania4 activity and -induced early protein 4 (ania-4) 0.00000 10145 ± 340 4640 ± 374 6078 ± 440 D32209_at Anp32a acidic nuclear phosphoprotein 32 family, member A 0.04959 2743 ± 119 2585 ± 247 3214 ± 159 S57478cds_s_at Anxa1 1 0.00001 852 ± 83 668 ± 22 1236 ± 64 L13039_s_at Anxa2 calpactin I heavy chain 0.00000 1218 ± 84 1274 ± 60 2896 ± 104 rc_AI171167_at Anxa4 ZAP 36/annexin IV 0.02526 175 ± 22 141 ± 21 226 ± 19 X86086_g_at Anxa6 annexin VI 0.00748 1919 ± 89 1873 ± 105 2237 ± 56 L07074_at Ap3m2 adaptor-related 3, mu 2 subunit 0.00357 3673 ± 86 3175 ± 61 3499 ± 100 AF029109_at Apba3 (A4) precursor protein-binding, family A, member 3 (X11-like 2) 0.01137 238 ± 19 205 ± 22 302 ± 22 X04979_at Apoe E 0.00000 21633 ± 889 6150 ± 971 14467 ± 1369 U14007_at Aqp4 4 0.00000 1579 ± 176 310 ± 55 1088 ± 79 AF026505_at Argbp2 Arg/Abl-interacting protein ArgBP2 0.00002 1022 ± 24 663 ± 38 818 ± 44 X77235_at Arl4 ADP-ribosylation-like 4 0.00705 1854 ± 72 1470 ± 123 1901 ± 78 M63282_at Atf3 Activating factor 3 0.00000 440 ± 54 1008 ± 42 1218 ± 47 D89514_at Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP 0.00001 1259 ± 71 1024 ± 101 1827 ± 86 rc_AI177026_at Atp1a2 ATPase, Na+K+ transporting, alpha 2 0.00000 2821 ± 97 371 ± 69 722 ± 76 D84450_at Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.00001 5623 ± 180 4600 ± 177 6063 ± 136 J04024_at Atp2a2 ATPase, Ca++ transporting, , slow twitch 2 0.00000 382 ± 22 173 ± 12 354 ± 21 rc_AI170268_at B2m Beta-2-microglobulin 0.00000 5666 ± 226 5071 ± 520 8985 ± 195

Page 1 Supplementary Table 1: Calcineurin-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN rc_H31839_at Bak1 BCL2-antagonist/killer 1 0.00010 512 ± 31 621 ± 53 832 ± 42 U17834_at Bgn biglycan 0.00011 1535 ± 77 952 ± 91 1306 ± 55 rc_AI102299_s_at Bid3 BH3 interacting domain 3 0.00721 1323 ± 44 1390 ± 148 1791 ± 94 X58830_at Bmp6 morphogenetic protein 6 0.00001 573 ± 26 562 ± 50 932 ± 55 M60921_g_at Btg2 B- translocation gene 2 0.01144 804 ± 75 759 ± 46 1018 ± 56 AF087037_at Btg3 B-cell translocation gene 3 0.00118 542 ± 31 638 ± 33 760 ± 40 D88250_at C1s complement component 1, s subcomponent 0.00000 320 ± 22 354 ± 67 909 ± 61 M29866_s_at C3 Complement component 3 0.00000 26 ± 12 662 ± 133 1932 ± 229 X58294_at Ca2 2 0.00004 1033 ± 65 662 ± 22 859 ± 33 rc_AI102839_at Calb1 1 0.00001 298 ± 27 99 ± 15 168 ± 18 M11597_at Calca /calcitonin-related polypeptide, alpha 0.00000 65 ± 7 107 ± 9 143 ± 8 rc_AI180288_s_at Cald1 Caldesmon 1 0.00009 352 ± 46 288 ± 34 597 ± 45 rc_AA892470_at Calm1 1 ( kinase, delta) 0.00000 1674 ± 53 802 ± 77 1210 ± 46 rc_AA894330_s_at Camk2d /calmodulin-dependent II, delta 0.00003 1458 ± 53 1286 ± 97 1885 ± 67 rc_AI171796_at Capn6 6 0.03391 266 ± 19 234 ± 21 316 ± 22 U10071_at Cart cocaine and amphetamine regulated transcript 0.00034 54 ± 15 94 ± 27 177 ± 14 Z46614cds_at Cav 0.00003 629 ± 65 530 ± 31 917 ± 44 X95986mRNA#1_f_at Cbr1 carbonyl reductase 1 0.00003 727 ± 41 775 ± 64 1133 ± 51 D14014_g_at Ccnd1 D1 0.02833 685 ± 51 560 ± 45 718 ± 27 rc_AA899106_at Ccnd2 cyclin D2 0.00000 10436 ± 402 3899 ± 268 6103 ± 268 rc_AA800005_at Cd151 CD151 0.00001 3130 ± 124 2386 ± 261 3901 ± 95 M61875_s_at Cd44 CD44 antigen 0.00764 735 ± 68 602 ± 101 1033 ± 94 X13016_at Cd48 CD48 antigen 0.00000 1054 ± 91 186 ± 23 470 ± 26 X61654_at Cd63 CD63 antigen 0.00000 9308 ± 219 6436 ± 347 9999 ± 349 rc_AI103957_g_at Cd81 CD 81 antigen 0.00000 16305 ± 183 10908 ± 412 13911 ± 410 X76489cds_g_at Cd9 CD9 antigen (p24) 0.00000 3049 ± 317 1002 ± 115 4081 ± 271 AF052695_at Cdc20 protein p55CDC 0.00000 391 ± 19 153 ± 16 218 ± 16 X60767mRNA_s_at Cdc2a cycle 2 homolog A (S. pombe) 0.00000 568 ± 36 165 ± 11 252 ± 14 U24174_at Cdkn1a cyclin-dependent kinase inhibitor 1A 0.00000 1419 ± 69 1498 ± 59 2056 ± 75 X60769mRNA_at Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.00000 1287 ± 99 1672 ± 97 2183 ± 80 M65149_at Cebpd CCAAT/enhancerbinding, protein (C/EBP) delta 0.00402 709 ± 28 401 ± 69 715 ± 75 D14437_s_at Cnn1 1 0.00165 129 ± 23 210 ± 38 345 ± 42 rc_AA944422_at Cnn3 calponin 3, acidic 0.00000 9697 ± 503 5305 ± 247 10040 ± 321 rc_AA892559_at Cntf Ciliary neurotropic factor 0.00003 498 ± 53 269 ± 31 587 ± 30 D38492_at Cntn1 contactin 1 0.01582 4014 ± 293 3480 ± 375 4696 ± 167 AJ005396_at Col11a1 procollagen, type XI, alpha 1 0.00402 335 ± 58 133 ± 14 282 ± 29 U57362_at Col12a1 procollagen, type XII, alpha 1 0.00000 209 ± 10 216 ± 12 311 ± 12 M27207mRNA_s_at Col1a1 , type 1, alpha 1 0.00195 3096 ± 419 1945 ± 180 3971 ± 371 rc_AA866454_at Col1a2 procollagen, type I, alpha 2 0.01559 395 ± 21 329 ± 15 392 ± 13 X70369_s_at Col3a1 collagen, type III, alpha 1 0.00001 639 ± 67 552 ± 32 1109 ± 78 rc_AA859757_g_at Col5a1 collagen, type V, alpha 1 0.01757 701 ± 42 735 ± 54 895 ± 46 rc_AI179399_at Col5a2 collagen, type V, alpha 2 0.00000 1050 ± 61 896 ± 65 2544 ± 57 AF001417_s_at Copeb core promoter element binding protein 0.00001 969 ± 51 1318 ± 64 1520 ± 60 X12554cds_s_at Cox6a2 cytochrome c , subunit VIa, polypeptide 2 0.00117 970 ± 38 727 ± 31 936 ± 46

Page 2 Supplementary Table 1: Calcineurin-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN L33869_at Cp 0.00000 417 ± 52 577 ± 53 1287 ± 63 rc_AA799667_at Cpsf4 cleavage and specific factor 4, 30kD subunit 0.00608 1493 ± 99 1511 ± 156 1970 ± 71 L07736_at Cpt1a carnitine palmitoyltransferase 1 0.00001 1250 ± 71 617 ± 53 916 ± 65 J05470_at Cpt2 Carnitine palmitoyltransferase 2 0.00000 539 ± 25 160 ± 12 332 ± 23 U04835_at Crem cAMP responsive element modulator 0.00016 208 ± 19 184 ± 19 336 ± 26 X60351cds_s_at Cryab , alpha B 0.00000 1320 ± 140 759 ± 83 2215 ± 128 rc_AI234146_at Csrp1 cysteine rich protein 1 0.00000 1523 ± 89 614 ± 38 1074 ± 47 rc_AI231292_at Cst3 cystatin C 0.00000 36212 ± 1059 17427 ± 1087 29814 ± 1519 M95768_at Ctbs di-N-acetylchitobiase 0.00008 268 ± 19 232 ± 12 348 ± 14 AB010428_s_at Cte1 cytosolic acyl-CoA 1 0.00000 1333 ± 100 224 ± 25 422 ± 34 D78591_at Ctf1 cardiotrophin 1 0.02350 325 ± 24 245 ± 20 314 ± 16 D17370_g_at Cth CTL target antigen 0.00029 77 ± 9 96 ± 5 132 ± 9 M38135_at Ctsh 0.00000 1336 ± 73 463 ± 34 747 ± 30 rc_AI176595_s_at Ctsl 0.00001 2500 ± 92 2840 ± 99 3515 ± 121 AF022247_at Cubn cubilin 0.00000 106 ± 10 105 ± 19 212 ± 7 U09229_at Cutl1 cut (Drosophila)-like 1 0.01866 597 ± 41 494 ± 31 663 ± 41 U90610_at Cxcr4 (LCR1) 0.00000 1992 ± 79 1167 ± 68 1483 ± 73 rc_AI010581_at Dbi diazepam binding inhibitor 0.00000 9334 ± 415 2043 ± 258 2960 ± 124 rc_AI170568_s_at Dci dodecenoyl-coenzyme A delta 0.00001 510 ± 22 175 ± 33 377 ± 42 L33894_at Dck 0.01371 147 ± 13 137 ± 13 199 ± 16 L26525_at Ddr1 Discoidin domain receptor family, member 1 0.00376 425 ± 29 344 ± 15 478 ± 26 D00569_g_at Decr1 2,4-dienoyl CoA reductase 1, mitochondrial 0.00000 1456 ± 77 304 ± 45 594 ± 43 rc_AI013795_at Dp1 dorsal protein 1 0.00273 136 ± 9 85 ± 8 119 ± 9 rc_AA924925_at Dri42 ER Dri 42 0.00000 1192 ± 33 382 ± 44 573 ± 57 U31668_at 5 0.00324 457 ± 23 369 ± 16 469 ± 19 rc_AA956930_s_at Ece1 converting 1 0.00853 236 ± 16 245 ± 25 323 ± 19 U08976_at Ech1 enoyl coenzyme A hydratase 1 0.00000 2937 ± 122 1698 ± 52 2173 ± 128 rc_AA848831_at Edg2 endothelial differentiation, G-protein-coupled receptor, 2 0.00000 236 ± 27 237 ± 22 445 ± 12 X57764_s_at Ednrb type B 0.00000 523 ± 34 169 ± 27 420 ± 34 U06713_at Egln3 EGL nine homolog 3 (C. elegans) 0.00073 731 ± 32 695 ± 32 902 ± 38 U48247_g_at Enh enigma homolog 0.00109 1230 ± 134 663 ± 76 1013 ± 50 AF023657_at Enman endo-alpha- 0.00622 357 ± 21 322 ± 29 423 ± 11 D28560_g_at Enpp2 ectonucleotide / 2 0.00025 61 ± 18 69 ± 10 143 ± 11 U21954_at Epha7 Eph receptor A7 0.00103 209 ± 30 260 ± 22 353 ± 20 U05014_at Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 0.00000 911 ± 47 1712 ± 90 2000 ± 98 X13411cds_s_at Ephb2 Eph receptor B2 0.01798 439 ± 62 411 ± 15 564 ± 26 M26125_at Ephx1 epoxide 1 0.00000 3457 ± 203 1272 ± 184 2265 ± 178 M81642_at F2r coagulation factor II receptor 0.00000 5192 ± 129 2389 ± 195 6061 ± 190 U61373_at F2rl1 Proteinase-activated receptor-2, -coupled receptor 11 0.00013 478 ± 47 534 ± 13 681 ± 18 J02773_at Fabp3 binding protein 3 0.02837 1542 ± 40 1249 ± 119 1517 ± 56 U02096_at Fabp7 fatty acid binding protein 7 0.00000 13656 ± 360 2447 ± 450 5324 ± 465 rc_AA875033_at Fbln5 5 0.00013 216 ± 18 269 ± 20 337 ± 12 AF098301_at Fbxo2 neural F box protein NFB42 0.00000 2783 ± 75 1281 ± 35 1764 ± 125 rc_AI180013_at Fcgrt , IgG, alpha chain transporter 0.00000 1946 ± 61 1050 ± 75 1592 ± 95

Page 3 Supplementary Table 1: Calcineurin-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN rc_AA819793_at Fen1 Flap structure-specific 1 0.00000 567 ± 42 926 ± 62 1098 ± 41 Z35138cds_s_at Fgfr2 receptor 2 0.01050 944 ± 61 708 ± 52 945 ± 53 X82152_at Fmod fibromodulin 0.00000 622 ± 32 150 ± 23 476 ± 47 L00191cds#1_s_at Fn1 1 0.00013 2707 ± 196 1643 ± 178 2751 ± 122 M81225_at Fnta , CAAX box, alpha 0.00000 2696 ± 81 1966 ± 35 2157 ± 43 L36388_at Foxj1 forkhead box J1 0.00000 352 ± 19 185 ± 15 343 ± 19 U57715_at Frag1 FGF receptor activating protein 1 0.00140 720 ± 27 573 ± 27 664 ± 18 rc_AA849769_g_at Fstl -like 0.00003 2688 ± 131 1819 ± 60 2620 ± 115 rc_AI169802_at Fth1 ferritin, heavy polypeptide 1 0.00310 27142 ± 628 23069 ± 518 26015 ± 852 rc_AI231807_at Ftl1 ferritin light chain 1 0.00000 14036 ± 343 11505 ± 600 16561 ± 501 X16145_at Fuca Fucosidase, alpha-L-1, tissue 0.00000 1948 ± 76 935 ± 35 1328 ± 43 AF061242_s_at Fxc1 fractured callus expressed transcript 1 0.01140 1303 ± 92 979 ± 43 1231 ± 64 rc_AA799645_g_at Fxyd1 FXYD domain-containing transport regulator 1 0.00000 276 ± 25 33 ± 7 174 ± 27 X57514_at Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.00000 1074 ± 83 467 ± 32 641 ± 28 L32591mRNA_g_at Gadd45a growth arrest and DNA-damage-inducible 45 alpha 0.00000 1356 ± 80 2211 ± 161 2689 ± 51 U35890_at Galnt1 polypeptide GalNAc T1 0.00180 787 ± 40 592 ± 41 784 ± 31 D42148_at Gas6 growth arrest specific 6 0.00000 3720 ± 99 1949 ± 107 2791 ± 180 J05181_at Gclc glutamate-cysteine catalytic subunit 0.00014 1196 ± 108 723 ± 47 1164 ± 41 S65555_g_at Gclm glutamate cysteine ligase, modifier subunit 0.00100 282 ± 17 250 ± 29 391 ± 25 rc_AA859837_g_at Gda 0.00003 2573 ± 113 2812 ± 127 3668 ± 156 AJ011969mRNA_at Gdf15 growth differentiation factor 15 0.00012 185 ± 23 287 ± 41 436 ± 33 D30735_at Gfer growth factor, erv1 -like 0.00007 360 ± 8 401 ± 24 503 ± 19 rc_AI029183_s_at Gja1 channel protein alpha 1 0.00001 1237 ± 136 323 ± 78 1109 ± 98 M91652complete_seq_g_at Glns 1 0.00000 14077 ± 650 3957 ± 289 10055 ± 796 rc_AI179613_at Glud1 1 0.00103 4616 ± 139 3695 ± 150 4239 ± 134 rc_AA859804_at Gm2a GM2 activator protein 0.01378 1861 ± 100 1925 ± 97 2319 ± 121 rc_AI232477_s_at Gng5 G protein gamma-5 subunit 0.00020 4283 ± 336 2601 ± 198 4841 ± 351 rc_AA925506_s_at Gng7 guanine nucleotide binding protein, gamma 7 0.03783 716 ± 44 602 ± 29 729 ± 31 U92081mRNA_s_at Gp38 glycoprotein 38 0.00399 832 ± 41 828 ± 43 1057 ± 57 L20468_at Gpc2 glypican 2 0.00045 477 ± 19 519 ± 36 658 ± 28 S61973_at Grina NMDA receptor glutamate-binding chain 0.02994 19073 ± 1099 18354 ± 761 21488 ± 641 X62322_g_at Grn granulin 0.00000 5367 ± 112 5920 ± 188 7290 ± 237 L38615_at Gss 0.04871 239 ± 16 186 ± 22 240 ± 11 S72505_f_at Gsta1 glutathione S-transferase, alpha 1 0.00000 9592 ± 564 2454 ± 413 5771 ± 351 X04229cds_s_at Gstm1 glutathione S-transferase, mu 1 0.00000 9881 ± 387 4419 ± 248 6930 ± 317 U86635_g_at Gstm5 glutathione S-transferase, mu 5 0.00000 2425 ± 125 563 ± 62 1199 ± 82 rc_AI012589_s_at Gstp1 glutathione-S-transferase, pi 1 0.00001 16173 ± 552 11777 ± 549 19955 ± 1141 X02904cds_s_at Gstp2 glutathione S-transferase, pi 2 0.00007 7966 ± 260 5790 ± 290 9657 ± 651 rc_AI138143_at Gstt2 glutathione S-transferase, theta 2 0.00000 466 ± 29 185 ± 28 312 ± 23 rc_AI044390_s_at Hmgb2 high mobility group box 2 0.00012 170 ± 15 160 ± 13 249 ± 12 rc_AI179610_at Hmox1 0.00000 1866 ± 116 3002 ± 305 8661 ± 623 K01933_at Hp Haptoglobin 0.00387 464 ± 21 498 ± 23 609 ± 34 X76453_at Hrasls3 HRAS like suppressor 0.00017 174 ± 15 53 ± 10 142 ± 19 rc_AA818604_s_at Hspa1a heat shock 70kD protein 1A 0.00013 118 ± 19 179 ± 22 277 ± 22

Page 4 Supplementary Table 1: Calcineurin-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN rc_AI176658_s_at Hspb1 heat shock 27kDa protein 1 0.00237 3157 ± 208 2796 ± 171 4054 ± 268 X15705cds_at Hspt70 testis-specific -related gene hst70 0.00003 488 ± 30 294 ± 17 425 ± 19 M64867_at Htr2a 5-hydroxytryptamine (serotonin) receptor 2A 0.00000 51 ± 7 84 ± 8 140 ± 11 L10073_at Htr5b 5-hydroxytryptamine (serotonin) receptor 5B 0.00000 746 ± 30 420 ± 25 669 ± 32 AF008554_at IAG2 implantation-associated protein 0.00007 605 ± 35 326 ± 20 594 ± 47 D00913_g_at Icam1 intercellular adhesion 1 0.00000 853 ± 95 1618 ± 234 2544 ± 158 D26178_at Ick intestinal cell kinase 0.00552 476 ± 34 411 ± 19 527 ± 14 L23148_g_at Id1 Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation) 0.00000 1254 ± 87 382 ± 58 1420 ± 66 rc_AI171268_at Id3 Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.00000 3257 ± 156 1027 ± 115 2351 ± 204 U59809_s_at Igf2r -like growth factor 2 receptor 0.00001 1996 ± 92 2093 ± 80 2760 ± 90 J04486_at Igfbp2 Insulin-like growth factor binding protein 2 0.00000 12334 ± 239 4352 ± 392 8153 ± 223 M31837_at Igfbp3 insulin-like growth factor binding protein 3 0.00001 1630 ± 127 1723 ± 64 2482 ± 95 M62781_at Igfbp5 insulin-like growth factor-binding protein 5 0.00154 678 ± 53 390 ± 29 837 ± 100 M92340_at Il6st 6 signal transducer 0.00723 447 ± 21 393 ± 35 532 ± 28 X65036_at Itga7 alpha 7 0.00000 366 ± 58 660 ± 30 1020 ± 47 AF020046_i_at Itgae integrin alpha E1, epithelial-associated 0.00000 171 ± 13 146 ± 15 716 ± 43 rc_AA900503_at Jag1 jagged 1 0.00000 702 ± 60 850 ± 44 1291 ± 52 X17163cds_s_at Jun v-jun sarcoma virus 17 homolog (avian) 0.03873 925 ± 59 754 ± 42 925 ± 45 rc_AI231213_g_at Kai1 kangai 1 0.00000 2247 ± 78 1590 ± 67 2074 ± 43 X76724_at Kcnab2 voltage gated channel, related subfamily, beta member 2 0.02463 332 ± 32 310 ± 24 423 ± 30 U70372_at Kist kinase interacting with leukemia-associated gene 0.00452 484 ± 44 290 ± 37 423 ± 27 L26292_at Kruppel-like factor 4 (gut) 0.00548 396 ± 36 468 ± 19 629 ± 61 L38644_at Kpnb1 karyopherin,beta 1 0.00000 864 ± 27 1002 ± 32 1187 ± 19 rc_AA946108_at Lama3 5 alpha 3 0.00848 112 ± 13 59 ± 12 115 ± 12 rc_AI104225_at Lamb2 Laminin chain beta 2 0.00123 603 ± 39 411 ± 36 585 ± 27 X94551_at Lamc1 laminin, gamma 1 0.00001 1624 ± 59 1430 ± 51 2243 ± 118 D90211_s_at Lamp2 Lysosomal-associated 2 0.00004 3663 ± 209 2106 ± 138 3053 ± 180 rc_AI145490_at Lbr B receptor 0.00236 83 ± 11 83 ± 7 127 ± 8 X54096_at Lcat Lecithin- 0.00000 651 ± 35 252 ± 36 637 ± 37 rc_AA946503_at Lcn2 2 0.00014 83 ± 21 1209 ± 403 2223 ± 285 rc_AI172064_at Lgals1 lectin, galactose binding, soluble 1 0.00000 2379 ± 112 1337 ± 137 5635 ± 257 J02962_at Lgals3 lectin, galactose binding, soluble 3 0.00001 692 ± 65 875 ± 86 1547 ± 125 D31873_at Limk1 LIM motif-containing protein kinase 1 0.00691 1875 ± 87 1623 ± 176 2185 ± 68 U53184_at Litaf LPS-induced TNF-alpha factor 0.00009 2250 ± 131 1716 ± 222 2992 ± 143 U24652_at Lnk linker of T-cell receptor pathways 0.00007 166 ± 11 174 ± 12 261 ± 15 D29960_at Loc192245 heat shock 20-kDa protein 0.00903 570 ± 19 493 ± 30 608 ± 22 rc_AA799423_at LOC246172 nexilin 0.00011 90 ± 8 42 ± 7 109 ± 10 AB012944cds_s_at LOC56813 parathyroid receptor 0.00628 175 ± 9 111 ± 11 158 ± 14 U40628_at LOC85383 unknown Glu-Pro dipeptide repeat protein 0.00006 257 ± 19 222 ± 9 329 ± 13 S66184_s_at Lox 0.02022 216 ± 29 121 ± 19 211 ± 22 rc_AI237731_s_at Lpl 0.00766 1450 ± 76 1450 ± 42 1760 ± 85 X84039_at Lum lumican 0.00035 183 ± 10 222 ± 16 352 ± 36 X76985_at Lxn latexin 0.00000 3231 ± 81 592 ± 101 1526 ± 100 AB017912_at Madh2 MAD homolog 2 (Drosophila) 0.00310 1489 ± 40 1558 ± 60 1735 ± 40

Page 5 Supplementary Table 1: Calcineurin-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN M23601_at Maob B 0.00066 415 ± 43 219 ± 20 357 ± 22 J05571_s_at Mat2a adenosyltransferase II, alpha 0.00222 2331 ± 186 2301 ± 181 3067 ± 108 U17565_at Mcmd6 mini maintenance deficient 6 (S. cerevisiae) 0.00000 399 ± 27 623 ± 29 946 ± 73 U65007_at Met met proto-oncogene 0.00003 239 ± 16 299 ± 29 417 ± 19 D16302_at Mgat1 N-acetylglucosaminyltransferase I 0.00079 789 ± 34 622 ± 22 813 ± 34 M76704_s_at Mgmt O6-methylguanine-DNA methyltranferase 0.00018 1215 ± 60 743 ± 63 1239 ± 85 rc_AI012030_at Mgp matrix Gla protein 0.00000 5924 ± 321 994 ± 74 1686 ± 104 J03752_at Mgst1 microsomal glutathione S-transferase 1 0.00002 2613 ± 126 1595 ± 170 3068 ± 183 X83537_at Mmp14 14, membrane-inserted 0.00001 1042 ± 68 727 ± 69 1328 ± 60 X02601_at Mmp3 matrix metalloproteinase 3 0.00000 223 ± 10 541 ± 94 1197 ± 92 X05566_i_at Mrlcb regulatory light chain 0.00000 1859 ± 39 1237 ± 118 1994 ± 34 X93591cds_at Msh2 mismatch repair protein 0.00463 1052 ± 43 939 ± 11 1100 ± 30 AF004811_at Msn moesin 0.00000 358 ± 28 348 ± 28 700 ± 35 D83036_at Msx1 homeo box, msh-like 1 0.00000 478 ± 30 231 ± 35 665 ± 34 rc_AI102562_at Mt1a Metallothionein 0.00021 5781 ± 470 3020 ± 410 5965 ± 435 rc_AA924772_at Mt3 metallothionein 3 0.00000 20085 ± 397 9129 ± 521 11176 ± 481 rc_AA799560_at Ndrg2 N- downstream-regulated gene 2 0.00000 6801 ± 249 1459 ± 214 3972 ± 255 M34384_at Nes 0.00000 800 ± 43 793 ± 39 1242 ± 48 U72660_at Ninj1 ninjurin 1 0.01646 1935 ± 146 1654 ± 104 2288 ± 159 AF110508_at Nos3 synthase 3 0.00989 611 ± 46 562 ± 75 856 ± 72 D90219_at Nppc natriuretic precursor C 0.00000 532 ± 30 544 ± 46 1072 ± 57 M26896_at Npr2 receptor 2 0.02331 225 ± 33 217 ± 17 303 ± 19 J02679_s_at Nqo1 NAD(P)H dehydrogenase, quinone 1 0.00000 2487 ± 266 1865 ± 133 7467 ± 286 L27124_s_at Nrd1 N- dibasic convertase 1 0.00000 2550 ± 71 3027 ± 92 3341 ± 49 U95001UTR#1_s_at Nudt4 diphosphoinositol polyphosphate phosphohydolase type II 0.00475 6463 ± 655 6962 ± 369 8746 ± 364 V01216_at Orm Orosomucoid 1 0.00080 161 ± 14 171 ± 23 260 ± 15 U22830_at P2ry1 P2Y, G-protein coupled 1 0.00203 54 ± 8 38 ± 6 82 ± 8 X78949_at P4ha1 prolyl 4-hydroxylase alpha subunit 0.00083 2334 ± 179 1953 ± 81 2642 ± 51 X02918_at P4hb Protein isomerase (Prolyl 4-hydroxylase, beta polypeptide) 0.04020 5588 ± 199 5128 ± 182 5862 ± 189 U52663mRNA#3_s_at Pam Peptidylglycine alpha-amidating monooxygenase 0.00016 7518 ± 300 5377 ± 246 6612 ± 272 U05989_at Pawr PRKC, , WT1, regulator 0.00005 339 ± 23 356 ± 39 630 ± 50 M24604_g_at Pcna Proliferating cell nuclear antigen 0.03762 2471 ± 115 1864 ± 63 2593 ± 268 M83745_at Pcsk2 proprotein convertase / type 2 0.03212 100 ± 9 100 ± 6 139 ± 15 U77880_at Pde7a phosphodiesterase 7A 0.00099 255 ± 9 287 ± 17 372 ± 25 U10357_at Pdk2 kinase 2 0.00000 1124 ± 49 619 ± 39 771 ± 31 U23769_at Pdlim1 PDZ and LIM domain 1 0.00004 1009 ± 44 1233 ± 31 1592 ± 98 S49491_s_at Penk-rs preproenkephalin, related sequence 0.00000 958 ± 51 766 ± 43 1353 ± 26 AJ224120_at Pex11a peroxisomal membrane protein Pmp26p (Peroxin-11) 0.00260 428 ± 20 459 ± 26 554 ± 25 rc_AI008677_s_at Phgdh 3-phosphoglycerate dehydrogenase 0.00000 1054 ± 72 416 ± 73 835 ± 41 D64047_at Pik3r3 3-kinase p55 subunit 0.01613 429 ± 18 448 ± 33 544 ± 30 rc_AA900750_s_at Plagl1 pleiomorphic adenoma gene-like 1 0.00001 443 ± 39 668 ± 44 863 ± 45 M23697_at Plat Plasminogen activator, tissue 0.00000 2382 ± 191 768 ± 104 2024 ± 71 AB000778_s_at Pld1 D gene 1 0.00000 200 ± 9 24 ± 6 71 ± 11 L25331_at Plod procollagen-, 2-oxoglutarate 5- 0.00000 414 ± 26 124 ± 23 390 ± 24

Page 6 Supplementary Table 1: Calcineurin-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN rc_AA892897_at Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 0.00000 729 ± 50 588 ± 29 1425 ± 30 rc_AA892859_g_at Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 0.00784 1636 ± 76 1495 ± 67 1840 ± 69 X70706cds_at Pls3 plastin 3 (T-isoform) 0.00049 1566 ± 75 1148 ± 55 1517 ± 64 S55427_s_at Pmp22 peripheral protein 22 0.00000 2044 ± 59 381 ± 31 1514 ± 101 X53231_at Porf1 preoptic regulatory factor-1 0.00285 388 ± 16 261 ± 22 412 ± 36 rc_AI230354_at Ppap2a phosphatidate phosphohydrolase type 2a 0.03425 2647 ± 33 2404 ± 102 2855 ± 145 rc_AA893191_g_at Ppap2c type 2c 0.02098 171 ± 18 143 ± 16 215 ± 17 AF065438_at Ppicap peptidylprolyl isomerase C-associated protein 0.00000 931 ± 54 1996 ± 158 2527 ± 133 rc_AI010083_at Prdx1 1 0.00007 7959 ± 252 5819 ± 438 7861 ± 184 Y17295cds_s_at Prdx6 peroxiredoxin 6 0.00000 3000 ± 125 1827 ± 30 2460 ± 83 M18330_g_at Prkcd , delta 0.00014 525 ± 29 456 ± 46 763 ± 49 D50093_s_at Prnp prion protein 0.01691 15267 ± 503 13008 ± 1277 16576 ± 540 U61729_at Prol2 proline rich 2 0.00002 986 ± 69 1067 ± 75 1750 ± 121 U06230_s_at Pros1 protein S 0.00551 445 ± 36 335 ± 39 499 ± 24 M19936_at Psap 0.02210 11162 ± 410 9693 ± 783 11741 ± 231 D10729_s_at Psmb8 (prosome, macropain) subunit, beta type, 8 0.00012 350 ± 42 559 ± 53 730 ± 52 D10757_at Psmb9 proteosome (prosome, macropain) subunit, beta type 9 0.00001 264 ± 43 397 ± 49 647 ± 41 D14869_s_at Ptger3 E receptor 3 0.00000 378 ± 10 702 ± 35 910 ± 30 U26595_at Ptgfrn prostaglandin F2 receptor negative regulator 0.01424 837 ± 24 710 ± 42 847 ± 30 rc_AI102795_at Ptn Pleiotrophin (Heparine binding factor, Hbnf, in the mouse) 0.00004 6164 ± 740 1716 ± 309 4624 ± 445 D38222_s_at Ptprn protein phosphatase, receptor type, N 0.00014 8530 ± 311 6729 ± 66 7715 ± 226 U28938_at Ptpro protein tyrosine phosphatase, receptor type, O 0.00111 5107 ± 124 4143 ± 208 5061 ± 164 rc_AA891669_g_at Rab11b RAB11B, member RAS oncogene family 0.00000 7722 ± 283 4833 ± 165 6993 ± 143 M83678_at Rab13 RAB13 0.00000 809 ± 37 377 ± 41 613 ± 37 rc_AA893443_at Rap1b RAP1B, member of RAS oncogene family 0.00021 8358 ± 162 8099 ± 191 9205 ± 143 U15211_at Rara , alpha 0.00000 3810 ± 346 4918 ± 201 8579 ± 345 D25233UTR#1_at Rb1 Retinoblastoma 1 (including osteosarcoma) 0.00326 422 ± 35 288 ± 21 369 ± 13 AJ001929_s_at Rcn reticulocalbin 0.00004 4498 ± 216 3731 ± 123 5126 ± 153 rc_AA894338_at Rdh10 10 (all-trans) 0.00121 338 ± 18 375 ± 25 458 ± 19 L25633_g_at Resp18 regulated endocrine-specific protein 18 0.04342 527 ± 67 371 ± 33 611 ± 73 X76454_at Ril Reversion induced LIM gene 0.00001 928 ± 24 445 ± 80 1457 ± 145 AF041066_at Rnase4 , RNase A family 4 0.00045 179 ± 12 122 ± 10 184 ± 8 X62528_at Rnh1 ribonuclease/ inhibitor 0.00000 1045 ± 24 1104 ± 19 1285 ± 24 X98490cds_at Rpa2 p32-subunit of replication protein A 0.00002 448 ± 27 271 ± 8 406 ± 20 M31018_f_at RT1Aw2 RT1 class Ib gene 0.00000 2225 ± 127 3410 ± 230 5038 ± 186 X06916_at S100a4 S100 calcium-binding protein A4 0.00000 745 ± 16 275 ± 21 547 ± 29 S53527mRNA_s_at S100b S100 calcium-binding protein, beta (neural) 0.00000 6828 ± 300 1384 ± 161 3475 ± 203 M62763complete_seq_at Scp2 Sterol carrier protein 2, 0.00001 2417 ± 89 1397 ± 75 1927 ± 121 X17053mRNA_s_at Scya2 small inducible A2 0.00000 2088 ± 169 7239 ± 1316 11555 ± 637 AF053312_s_at Scya20 small inducible cytokine subfamily A20 0.00016 87 ± 6 321 ± 90 1418 ± 279 S61865_s_at Sdc1 syndecan 1 0.00000 165 ± 18 444 ± 26 650 ± 57 M81687_at Sdc2 syndecan 2 0.00142 1236 ± 95 736 ± 96 1124 ± 64 S61868_at Sdc4 syndecan 4 0.00592 3459 ± 357 2261 ± 130 3055 ± 155 A03913cds_s_at Serpine2 (or cysteine) proteinase inhibitor, clade E, member 2 0.00000 2724 ± 87 754 ± 87 1369 ± 139

Page 7 Supplementary Table 1: Calcineurin-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN M69246_at Serpinh1 serine (or cysteine) proteinase inhibitor, clade H, member 1 0.00000 2133 ± 165 1560 ± 94 3739 ± 93 L01624_at Sgk /glucocorticoid regulated kinase 0.00436 1355 ± 70 1243 ± 61 1599 ± 73 U55815_at Slc12a4 solute carrier family 12, member 4 0.00000 864 ± 39 483 ± 38 814 ± 35 U81518_at Slc14a1 solute carrier family 14, member 1 0.00003 669 ± 79 261 ± 29 620 ± 36 X63744_g_at Slc1a3 solute carrier family 1, member 3 0.00000 2570 ± 201 494 ± 111 1288 ± 47 S68135_s_at Slc2a1 solute carrier family 2,member 1 0.00000 3137 ± 216 1321 ± 87 2698 ± 108 U76714_at Slc39a1 solute carrier family 39 (iron-regulated transporter), member 1 0.00000 215 ± 27 284 ± 16 485 ± 22 J05166_g_at Slc4a2 solute carrier family 4, member 2 0.00170 414 ± 19 313 ± 59 534 ± 28 AJ001290cds_at Slc5a3 solute carrier family 5 (inositol transporters), member 3 0.00000 1665 ± 63 812 ± 36 1010 ± 61 AF052596_at Snap23 synaptosomal-associated protein, 23 kD 0.00218 270 ± 15 160 ± 21 265 ± 23 D86373_s_at Soat1 acyl-coenzyme A:cholesterol acyltransferase 0.01097 368 ± 25 297 ± 16 400 ± 23 Z24721_at Sod3 superoxide 3 0.00000 922 ± 92 704 ± 80 1663 ± 96 AJ131888_at Sp17 sperm autoantigenic protein 17 0.00025 249 ± 29 91 ± 21 203 ± 16 U75928UTR#1_s_at Sparc Secreted acidic cystein-rich glycoprotein () 0.00000 8679 ± 576 3494 ± 454 8558 ± 445 rc_AA891204_s_at Sparc Secreted acidic cystein-rich glycoprotein (osteonectin) 0.00000 1877 ± 88 671 ± 85 1959 ± 61 U27562_at Sparcl1 SPARC-like 1 0.00000 14436 ± 687 7858 ± 288 9667 ± 488 M14656_at Spp1 secreted phosphoprotein 1 0.00002 792 ± 76 298 ± 32 681 ± 52 U62667_at Stc1 stanniocalcin 1 0.00000 165 ± 16 247 ± 14 321 ± 9 U37138_at Sts 0.00108 306 ± 20 215 ± 18 302 ± 10 AF039085_at Syngr2 synaptogyrin 2 0.00009 486 ± 23 414 ± 46 647 ± 23 AF000423_at Syt11 11 0.01040 1376 ± 173 1289 ± 147 2049 ± 195 M15191_s_at Tac1 Tachykinin (substance P, neurokinin A, K, neuropeptide gamma) 0.00000 504 ± 22 1309 ± 134 1809 ± 154 X57523_g_at Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.00000 380 ± 32 900 ± 45 1084 ± 68 L46816_at Tceb3 transcription B (SIII), polypeptide 3 0.01204 317 ± 14 294 ± 31 409 ± 29 L09656_at Tcf12 Transcription factor 12 0.03201 513 ± 43 511 ± 40 641 ± 32 X75856_at Tegt Testis enhanced gene transcript 0.00000 9164 ± 300 6357 ± 270 8060 ± 250 D38380_at Tf Transferrin 0.00000 214 ± 49 450 ± 95 1601 ± 151 U03491_at Tgfb3 transforming growth factor, beta 3 0.00029 531 ± 60 475 ± 30 786 ± 48 rc_AI169327_at Timp1 tissue inhibitor of metalloproteinase 1 0.00036 1590 ± 43 1131 ± 85 1433 ± 59 rc_AI169327_g_at Timp1 tissue inhibitor of metalloproteinase 1 0.00002 744 ± 43 446 ± 37 638 ± 22 U27201_at Timp3 Tissue inhibitor of metalloproteinase 3 0.02337 489 ± 40 394 ± 51 552 ± 24 U59241_at Tmod1 1 0.00000 318 ± 19 335 ± 20 568 ± 35 U18314_g_at Tmpo 0.00001 755 ± 32 1014 ± 69 1237 ± 51 U09361_s_at Tnc tenascin C 0.00000 569 ± 55 393 ± 24 1287 ± 55 M63122_at Tnfrsf1a receptor superfamily, member 1a 0.00004 1490 ± 66 802 ± 99 1521 ± 104 U26310_at Tns tensin 0.02282 836 ± 53 653 ± 31 840 ± 54 X02412_at Tpm1 1, alpha 0.00028 1225 ± 118 607 ± 59 1213 ± 99 J02780_at Tpm4 Tropomycin 4 0.00000 823 ± 21 856 ± 49 1512 ± 43 rc_AI012275_at Tpo1 developmentally regulated protein TPO1 0.00836 898 ± 57 638 ± 40 818 ± 54 AB006914_at Trip10 thyroid interactor 10 0.00006 368 ± 26 421 ± 21 542 ± 21 AB008889_at Trpc4 transient receptor protein 4 0.00084 692 ± 43 776 ± 75 1005 ± 37 rc_AA891286_at Txnrd1 1 0.00000 5352 ± 132 6749 ± 160 8194 ± 217 U83883_at U83883 p105 coactivator 0.02531 3267 ± 142 2978 ± 124 3460 ± 89 AB010743_at Ucp2 Uncoupling protein 2, mitochondrial 0.00000 3398 ± 168 2038 ± 120 3196 ± 99

Page 8 Supplementary Table 1: Calcineurin-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN Y00350_at Urod uroporphyrinogen decarboxylase 0.00052 793 ± 33 627 ± 22 719 ± 17 AF054826_at Vamp5 vesicle-associated membrane protein 5 0.02088 140 ± 5 113 ± 20 177 ± 15 X62952_at Vim 0.00000 22032 ± 1311 9643 ± 943 23421 ± 1729 U96490_g_at Yif1p Yip1p-interacting factor 0.00020 2316 ± 44 2116 ± 71 2530 ± 55 rc_AI112516_at Zfp36l1 protein 36, C3H type-like 1 0.00020 2338 ± 250 1129 ± 177 2216 ± 107 rc_AI170608_at Znf265 zinc finger protein 265 0.00208 5347 ± 176 6111 ± 542 7228 ± 210 Downregulated with Calcineurin L22557_at 1G5 vesicle-associated calmodulin-binding protein 0.00009 2215 ± 60 2478 ± 89 1906 ± 71 J05210_g_at Acly ATP citrate 0.00112 17733 ± 409 17121 ± 325 14724 ± 656 Y08616cds_at Adam1 a disintegrin and metalloproteinase domain 1 (fertilin alpha) 0.04743 351 ± 22 402 ± 36 294 ± 28 X80290cds_s_at Adcyap1 adenylate cyclase activating polypeptide 1 0.00081 885 ± 23 1128 ± 55 960 ± 29 M86341_at Adprh ADP-ribosylarginine hydrolase 0.00009 757 ± 21 1081 ± 62 853 ± 32 S48813_s_at Adrbk1 kinase, beta 1 0.00873 887 ± 32 888 ± 59 727 ± 24 AF065150_s_at Ank3 3 (G) 0.00058 100 ± 13 172 ± 11 105 ± 11 M77245_at Ap1b1 adaptor protein complex AP-1, beta 1 subunit 0.00022 3225 ± 145 3831 ± 137 2989 ± 84 U75917_at Ap2s1 -associated protein 17 0.03902 6669 ± 283 7463 ± 255 6638 ± 178 M65148_s_at Atf2 RATF2 0.00272 1095 ± 89 1449 ± 52 1233 ± 39 M96626_g_at Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 0.00947 418 ± 28 556 ± 36 455 ± 22 X56133_at Atp5a1 mitochondrial H+-ATP synthase alpha subunit 0.03950 10736 ± 233 11045 ± 289 9786 ± 419 L19927_at Atp5c1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 0.00007 13337 ± 310 15935 ± 454 12514 ± 494 U00926_at Atp5d ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit 0.00009 8186 ± 306 9734 ± 226 7929 ± 207 D13123_s_at Atp5g1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c, isoform 1 0.00086 15483 ± 403 19057 ± 859 16083 ± 429 rc_AI639020_at Atp5o ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 0.00000 565 ± 33 811 ± 26 668 ± 12 U30831_at B/K B/K protein 0.00031 1888 ± 128 1707 ± 61 1359 ± 36 AF048687_s_at B4galt6 UDP-Gal:betaGlcNAc beta 1,4-, polypeptide 6 0.01895 6453 ± 266 6658 ± 354 5484 ± 263 Y09332cds_s_at Bach acyl-CoA hydrolase 0.00109 9729 ± 451 11301 ± 507 8517 ± 406 rc_AA818072_s_at Bad bcl-2 associated death 0.00000 8543 ± 105 7463 ± 230 6537 ± 163 U59184_at Bax bcl2-associated X protein 0.02637 9433 ± 417 10119 ± 305 8886 ± 184 U75392_s_at Bcap27 B-cell receptor-associated protein 37 0.00000 7430 ± 161 10843 ± 363 9348 ± 328 Y07704_at Best5 Best5 protein 0.00000 172 ± 24 1836 ± 209 1167 ± 127 rc_AI178135_at C1qbp complement component 1, q subcomponent binding protein 0.00003 3639 ± 108 4376 ± 95 3844 ± 59 Y17048_g_at Cabp1 calcium binding protein 1 0.02489 845 ± 51 907 ± 49 727 ± 35 Y09453cds_at Cacng1 , voltage-dependent, gamma subunit 1 0.04789 290 ± 18 340 ± 19 278 ± 15 AF061947_g_at Cain cain 0.03466 2283 ± 110 2683 ± 111 2227 ± 132 M16960_s_at Camk2a calcium/calmodulin-dependent protein kinase II alpha subunit 0.01282 307 ± 17 301 ± 30 214 ± 20 M16112_g_at Camk2b calcium/calmodulin-dependent protein kinase II beta subunit 0.00154 21379 ± 814 20889 ± 939 17088 ± 692 J04063_at Camk2g calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 0.00110 1423 ± 54 1442 ± 49 1178 ± 45 X01032_at Cck 0.00000 4485 ± 147 3565 ± 91 2939 ± 131 D26564_g_at Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.00005 7700 ± 314 9956 ± 349 8631 ± 143 rc_AA942685_at Cdo1 cytosolic 1 0.00705 5072 ± 149 5992 ± 242 5259 ± 162 U51013_at Centa1 centaurin, alpha 1 0.01505 2516 ± 162 2688 ± 107 2062 ± 153 U66470_at Cgr11 regulatory with EF-hand domain 0.00002 1031 ± 62 843 ± 16 726 ± 15 rc_AA892496_at Chn2 chimerin (chimaerin) 2 0.00017 699 ± 38 1206 ± 69 908 ± 74

Page 9 Supplementary Table 1: Calcineurin-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN M16407_at Chrm3 cholinergic receptor, muscarinic 3 0.04026 1981 ± 50 2013 ± 74 1824 ± 39 rc_AA893210_at Copb2 beta prime COP 0.00083 2206 ± 68 2794 ± 121 2186 ± 111 rc_AA892506_at Coro1a coronin, actin binding protein 1A 0.00001 4961 ± 261 5200 ± 256 3456 ± 136 rc_AI229620_s_at Cox5b cytochrome c oxidase subunit Vb 0.02268 15348 ± 537 16870 ± 469 15094 ± 344 AF039203UTR#1_at Crhr1 corticotropin releasing hormone receptor 1 0.00001 509 ± 14 471 ± 28 337 ± 17 X83867cds_s_at Cyp1b1 , subfamily 1B, polypeptide 1 0.00008 415 ± 27 685 ± 30 559 ± 37 rc_AI169372_at Cyp2c23 epoxygenase 0.01256 855 ± 47 838 ± 60 677 ± 24 rc_AI177919_at Cyp2d5 cytochrome P450CMF1b 0.00001 3073 ± 83 4265 ± 123 3779 ± 137 Z36980_at Ddt D-dopachrome tautomerase 0.00000 4017 ± 101 3797 ± 119 3170 ± 52 D38448_at Dgkg , gamma 0.00014 870 ± 28 813 ± 31 667 ± 27 D10655_at Dlat dihydrolipoamide 0.01683 5042 ± 228 5945 ± 212 5200 ± 188 U67137_at Dlgap1 associated protein 0.00621 966 ± 77 1200 ± 48 962 ± 30 D26495_at Dnch2 , cytoplasmic, heavy chain 2 0.00312 243 ± 27 218 ± 7 147 ± 16 AF020211_s_at Dnm1l 1-like 0.00069 2978 ± 103 2672 ± 242 2040 ± 87 D89340_at Dpp3 dipeptidylpeptidase III 0.03376 1974 ± 72 2193 ± 58 1976 ± 54 U52103_at Dpys4 -like 4 0.04296 3658 ± 203 3772 ± 108 3256 ± 119 AF023087_s_at Egr1 early growth response 1 0.00001 17429 ± 1567 12488 ± 783 8185 ± 508 U78102_at Egr2 early growth response 2 0.00014 663 ± 52 533 ± 32 411 ± 16 rc_AI031019_g_at Eif2b1 translation initiation factor eIF-2B alpha-subunit 0.00085 1218 ± 39 1558 ± 49 1381 ± 56 U38253_g_at Eif2b3 eukaryotic translation initiation factor 2B, subunit 3 (gamma, 58kD) 0.00040 979 ± 34 1213 ± 39 1005 ± 35 J02646_at Eif2s1 eukaryotic translation initiation factor 2, subunit 1 (alpha ) 0.00000 3693 ± 41 5367 ± 100 4815 ± 193 rc_AI236284_s_at Facl4 fatty acid Coenzyme A ligase, long chain 4 0.02565 6537 ± 113 6971 ± 150 6204 ± 228 AB012933_g_at Facl5 fatty acid Coenzyme A ligase, long chain 5 0.00000 2329 ± 46 2016 ± 41 1662 ± 80 AJ005046_g_at Fbp2 fructose bisphosphatase 2 0.00085 453 ± 35 581 ± 21 410 ± 25 M95591_g_at Fdft1 farnesyl diphosphate farnesyl transferase 1 0.00000 2966 ± 120 3845 ± 89 2871 ± 88 M89945mRNA_at Fdps farensyl diphosphate synthase 0.00040 8964 ± 405 10931 ± 308 9070 ± 238 rc_AI171734_s_at Fh1 fumarate hydratase 1 0.00095 1489 ± 48 1496 ± 45 1181 ± 69 rc_AI136977_g_at Fkbp4 FK506 binding protein 4 (59 kDa) 0.02044 1163 ± 77 1168 ± 79 925 ± 47 rc_AI230914_at Fntb farnesyltransferase beta subunit 0.00001 878 ± 30 1252 ± 57 925 ± 35 U11681_at Frap1 FK506 binding protein 12-rapamycin associated protein 1 0.00548 2552 ± 90 2401 ± 99 2014 ± 122 X51992_at Gabra5 gamma-aminobutyric acid A receptor, alpha 5 0.00018 6552 ± 213 6491 ± 300 5239 ± 111 M72422_at Gad2 2 (islet) 0.04467 1162 ± 63 1216 ± 83 1006 ± 33 D17809_at Galgt1 beta-4N-acetylgalactosaminyltransferase 0.00565 2855 ± 120 2732 ± 79 2397 ± 81 L21192_at Gap43 growth associated protein 43 0.01584 19135 ± 561 21124 ± 701 18926 ± 343 rc_AI145044_at Glra2 receptor alpha 2 subunit (, neonatal) 0.00088 6531 ± 311 6868 ± 201 5532 ± 165 M17527_at Gnai1 Guanine nucleotide binding protein, alpha inhibiting 1 0.00444 5272 ± 300 6809 ± 264 5469 ± 318 U77483mRNA_s_at Gnaz Guanine nucleotide binding protein, alpha 0.00039 2110 ± 79 2400 ± 53 1969 ± 58 rc_AA799779_g_at Gnpat acyl-CoA:dihydroxyacetonephosphate acyltransferase 0.00012 3417 ± 178 4278 ± 53 3448 ± 113 rc_AI170776_s_at Grb2 bound protein 2 0.01685 3925 ± 147 4620 ± 106 4045 ± 188 X59996mRNA_s_at Grik4 , ionotropic, kainate 4 0.00206 534 ± 37 462 ± 36 327 ± 37 rc_AA800033_at Grin3b glutamate receptor, ionotropic, NMDA3B 0.00847 1684 ± 145 2173 ± 105 1813 ± 44 AF090113_g_at Grip2 glutamate receptor interacting protein 2 0.01012 1215 ± 52 1427 ± 70 1207 ± 31 D16817_at Grm7 metabotropic glutamate receptor mGluR7 0.00114 1018 ± 36 979 ± 23 849 ± 28 rc_AA849036_at Gucy1a3 1, soluble, alpha 3 0.00320 779 ± 25 701 ± 60 558 ± 34

Page 10 Supplementary Table 1: Calcineurin-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN rc_AI177503_at H3f3b H3 histone, family 3B 0.00000 10818 ± 405 18572 ± 334 15906 ± 661 rc_AA866238_at Hcn1 hyperpolarization-activated, -gated 1 0.00453 718 ± 47 911 ± 58 599 ± 65 rc_AA892297_at Hdac2 2 0.00668 4621 ± 211 5490 ± 284 3743 ± 430 D37951UTR#1_at Hivep2 immunodeficiency virus type 1 enhancer-binding protein 2 0.00000 5287 ± 184 4188 ± 147 3457 ± 108 M29249cds_at Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase 0.00141 4490 ± 187 5708 ± 176 4994 ± 200 X52625_at Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 0.00020 21796 ± 872 22664 ± 684 17415 ± 793 AF093268_s_at Homer1 homer, neuronal immediate early gene, 1 0.00364 2232 ± 98 2365 ± 107 1761 ± 134 D12573_at Hpca 0.00000 5030 ± 308 3995 ± 81 3074 ± 104 rc_AI105448_at Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 0.00000 2918 ± 151 1272 ± 62 838 ± 82 rc_AI236145_at Hsd17b7 hydroxysteroid dehydrogenase 17 beta, type 7 0.04623 590 ± 37 631 ± 26 518 ± 29 X54793_at Hsp60 heat shock protein 60 (liver) 0.02154 14457 ± 320 16306 ± 766 14554 ± 255 Z22812_at Il1r2 interleukin 1 receptor, type II 0.00036 515 ± 31 694 ± 51 460 ± 22 U48592_at Il1rap Interleukin 1 receptor accessory protein 0.03214 188 ± 12 252 ± 27 192 ± 11 rc_AI639291_at Itga8 integrin alpha 8 0.00048 264 ± 7 285 ± 9 224 ± 11 rc_AI102838_s_at Ivd Isovaleryl Coenzyme A dehydrogenase 0.00000 1573 ± 59 1110 ± 33 962 ± 33 AJ000557cds_s_at Jak2 2 (a protein ) 0.01961 283 ± 25 362 ± 30 257 ± 21 rc_AI230211_s_at Kcnd3 potassium voltage gated channel, Shal-related family, member 3 0.00086 960 ± 47 792 ± 85 592 ± 42 M81784_at Kcng1 potassium voltage-gated channel subfamily G member 1 0.00309 512 ± 34 592 ± 35 420 ± 27 AF022819_at Kcnk1 putative potassium channel TWIK 0.00019 1429 ± 48 1829 ± 98 1301 ± 69 M86235_at Khk Ketohexokinase 0.00009 582 ± 41 945 ± 59 734 ± 35 M75148_at Klc1 light chain 1 0.01663 13861 ± 470 15141 ± 400 13548 ± 268 U66707_at LOC117284 densin-180 0.00363 419 ± 36 505 ± 37 328 ± 27 U93197_at LOC171116 RN protein 0.00000 758 ± 38 1218 ± 66 913 ± 27 rc_AI105044_at LOC246270 estrous-specific protein, 250 kDa 0.00344 3321 ± 118 3871 ± 112 3263 ± 122 D63411_s_at LOC266601 outer mitochondrial membrane receptor rTOM20 0.00480 5427 ± 239 6593 ± 201 5742 ± 211 Z83869cds_at LOC60328 serine/ kinase 0.00097 798 ± 43 704 ± 53 560 ± 22 L13619_at LOC64194 growth response protein (CL-6) 0.00000 5494 ± 169 5045 ± 176 3933 ± 121 rc_AI639282_s_at LOC83503 II 0.00075 4513 ± 121 4929 ± 137 4237 ± 74 AB009463_g_at Lrp3 low density lipoprotein receptor-related protein 3 0.00165 750 ± 33 791 ± 19 597 ± 43 Z11995cds_g_at Lrpap1 low density lipoprotein receptor-related protein associated protein 1 0.00045 951 ± 28 900 ± 19 810 ± 18 D45252_s_at Lss 2,3-oxidosqualene: cyclase 0.01346 2033 ± 34 2028 ± 66 1818 ± 57 rc_AA892775_at Lyz 0.00007 503 ± 57 461 ± 41 216 ± 22 U48596_g_at Map3k1 activated protein kinase kinase kinase 1 0.00861 451 ± 35 631 ± 54 495 ± 21 D49785_at Map3k12 mitogen activated protein kinase kinase kinase 12 0.00447 3261 ± 133 4125 ± 176 3501 ± 162 U73142_g_at Mapk14 mitogen activated protein kinase 14 0.02750 2117 ± 127 2426 ± 138 1913 ± 113 AF092450_at Mapk8ip mitogen activated protein kinase 8 interacting protein 0.03656 2358 ± 136 2615 ± 167 2123 ± 83 rc_AI227608_s_at Mapt -associated protein tau 0.00344 38201 ± 1237 38452 ± 1526 32778 ± 907 rc_AI071498_at Mas1 MAS1 oncogene 0.00000 1195 ± 77 1064 ± 43 689 ± 30 AF004661_at Masp1 mannose-binding protein associated serine -1 0.02372 4003 ± 68 4908 ± 225 4147 ± 268 AF093773_s_at Mdh1 1 0.01499 22290 ± 644 24483 ± 691 22006 ± 453 X01785_at Mox2 antigen identified by monoclonal antibody MRC OX-2 0.00029 6118 ± 192 6565 ± 144 4978 ± 294 D50564_at Mpst mercaptopyruvate 0.00007 2275 ± 102 1986 ± 43 1738 ± 53 U02522_at Mta1 metastasis associated 1 0.01355 2478 ± 90 2547 ± 71 2252 ± 49 AJ002556_s_at Mtap6 microtubule-associated protein 6 0.01544 1671 ± 78 1750 ± 55 1480 ± 55

Page 11 Supplementary Table 1: Calcineurin-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN M76740_at Muc3 Mucin3 0.02192 217 ± 39 334 ± 34 224 ± 17 U53706_at Mvd mevalonate pyrophosphate decarboxylase 0.00158 2130 ± 57 2240 ± 62 1896 ± 59 rc_AA924198_s_at Mvk 0.01049 791 ± 24 775 ± 29 667 ± 31 X68199_at Myo1b myosin Ib 0.00375 584 ± 53 526 ± 13 405 ± 28 U60416_at Myo5b myosin 5B 0.00778 902 ± 22 891 ± 65 713 ± 36 X89968_at Napa N-ethylmaleimide sensitive fusion protein attachment protein alpha 0.00457 2139 ± 37 2239 ± 74 1969 ± 43 rc_AA818677_at Nefh , heavy polypeptide 0.00001 706 ± 46 1143 ± 50 829 ± 43 U48246_at Nell1 protein kinase C-binding protein NELL1 0.00005 2163 ± 115 2138 ± 89 1521 ± 75 X66022mRNA#1_s_at Neud4 neuronal d4 domain family member 0.00018 5850 ± 157 5799 ± 117 5125 ± 70 rc_AI233173_at Nme1 expressed in non-metastatic cells 1 0.00063 7299 ± 127 9355 ± 205 8050 ± 400 AB015724_g_at Nrbf1 binding factor 1 0.00800 553 ± 23 569 ± 24 478 ± 15 U88958_at Nrn neuritin 0.00000 8554 ± 237 7985 ± 233 6431 ± 160 L31840_at Nup107 nuclear pore complex protein 0.00347 1058 ± 31 1292 ± 24 1136 ± 53 D13126_at NVP-3 neural visinin-like Ca2+-binding protein type 3 0.00004 1211 ± 69 1743 ± 82 1404 ± 37 L27867_at Nxph1 Neurexophilin 1 0.00003 2153 ± 135 2050 ± 57 1516 ± 47 AF042714_at Nxph4 neurexophilin 4 0.00393 601 ± 55 833 ± 42 687 ± 29 M93297cds_at Oat aminotransferase 0.00000 3325 ± 83 2652 ± 112 2326 ± 68 U03414_s_at Olfm1 olfactomedin related ER localized protein 0.00055 15258 ± 410 14273 ± 418 12660 ± 379 AF031528_s_at Opn1mw 1 (cone pigments), medium-wave-sensitive 0.03994 555 ± 43 666 ± 47 493 ± 44 rc_AA899935_at Pafah1b2 platelet-activating factor acetylhydrolase alpha 2 subunit 0.00008 2208 ± 107 2913 ± 86 2534 ± 66 M24067_at Pai1 serine (or cysteine) proteinase inhibitor, member 1 0.00001 497 ± 25 898 ± 54 693 ± 39 M24852_at Pcp4 specific protein PEP-19 ( protein 4) 0.00029 14117 ± 164 13189 ± 308 12202 ± 300 AF080568_g_at Pcyt2 cytidylyltransferase 2, ethanolamine 0.01450 2177 ± 200 2736 ± 115 2239 ± 68 Z14120cds_s_at Pdgfa Platelet-derived growth factor A chain 0.00001 445 ± 18 407 ± 19 305 ± 12 D63673_at Pex6 peroxisomal biogenesis factor 6 0.00000 1309 ± 43 1931 ± 49 1684 ± 69 rc_AI169631_s_at Phb Prohibitin 0.00000 3604 ± 133 4977 ± 166 4324 ± 81 U39572_s_at Pik4ca phosphatidylinositol 4-kinase 0.00359 3931 ± 121 3795 ± 69 3392 ± 110 AF086624_s_at Pim3 serine threonine kinase pim3 0.00004 1504 ± 49 1852 ± 96 1230 ± 72 D21132_at Pitpnb phosphotidylinositol transfer protein, beta 0.00036 3412 ± 142 4143 ± 168 3415 ± 37 rc_AI639353_at Plrg1 pleiotropic regulator 1 0.00000 3196 ± 64 4524 ± 120 4136 ± 102 AB020504_g_at Pmf31 PMF32 protein 0.00307 2522 ± 100 2470 ± 132 1975 ± 103 S79730_s_at Pnoc Prepronociceptin (neuropeptide nociceptin) (N23K) 0.03559 2227 ± 62 2682 ± 215 2158 ± 114 Z71925_at Polr2g polymerase (RNA) II (DNA directed)polypeptide G 0.00001 5130 ± 108 6179 ± 140 5466 ± 83 rc_AI178208_at Pom121 nuclear pore membrane glycoprotein 121 kD 0.00000 1079 ± 47 1672 ± 52 1497 ± 30 Y00826_at Pom210 nuclear pore membrane glycoprotein 210 0.00474 581 ± 25 690 ± 17 597 ± 21 D14568_at Ppp3r1 protein phospatase 3, regulatory subunit B, alpha isoform,type 1 0.00630 5061 ± 437 5972 ± 286 4463 ± 174 D14421_at Pppr2b2 2 (formerly 2A), regulatory subunit B (PR 52), beta 0.00005 5892 ± 200 6229 ± 191 4924 ± 130 U06099_at Prdx2 peroxiredoxin 2 0.02349 15852 ± 378 15974 ± 486 14443 ± 376 X04139_s_at Prkcb1 protein kinase C, beta 1 0.00048 5010 ± 112 5635 ± 251 4486 ± 138 X07287cds_s_at Prkcc protein kinase C, gamma 0.00000 2574 ± 130 1748 ± 47 1454 ± 63 M18332_s_at Prkcz protein kinase C, zeta 0.00243 2449 ± 67 2754 ± 59 2455 ± 53 M74152_s_at Prlr receptor 0.00000 110 ± 18 303 ± 15 224 ± 9 E03358cds_at Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.00609 5425 ± 235 6595 ± 242 5702 ± 210 D90258_s_at Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.00896 7685 ± 252 9195 ± 320 7924 ± 348

Page 12 Supplementary Table 1: Calcineurin-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN D10756_at Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.00046 3176 ± 100 3522 ± 156 2703 ± 111 rc_AI172162_at Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.00002 6347 ± 197 8487 ± 243 7422 ± 241 D10754_g_at Psmb6 proteasome (prosome, macropain) subunit, beta type 6 0.00128 5202 ± 142 6314 ± 183 5602 ± 184 D50696_at Psmc1 protease (prosome, macropain) 26S subunit, ATPase 1 0.00001 4425 ± 103 5803 ± 129 5302 ± 170 rc_AA799887_s_at Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase,4 0.00217 2525 ± 113 2875 ± 106 2305 ± 84 S67722_s_at Ptgs2 prostaglandin-endoperoxide synthase 2 0.00359 319 ± 21 574 ± 42 387 ± 57 L19180_g_at Ptprd protein tyrosine phosphatase, receptor type, D 0.00003 13146 ± 473 12269 ± 418 10174 ± 246 D78613_s_at Ptpre Protein tyrosine phosphatase, receptor type, epsilon polypeptide 0.03693 692 ± 27 699 ± 31 592 ± 33 M83680_at Rab14 GTPase Rab14 0.01802 2422 ± 66 2481 ± 91 2170 ± 72 AA799389_g_at Rab3b Rab3B protein 0.00056 2608 ± 69 2861 ± 82 2398 ± 62 X78605_at Rab4b ras-related GTP-binding protein 4b 0.00186 3321 ± 183 3140 ± 96 2667 ± 67 L19698_at Rala v-ral simian leukemia viral oncogene homolog A (ras related) 0.00012 2591 ± 82 3267 ± 96 2646 ± 101 L19699_g_at Ralb v-ral simian leukemia viral oncogene homolog B 0.00000 1133 ± 48 860 ± 54 593 ± 28 AF022081_at Rnf4 ring finger protein 4 0.00000 1780 ± 161 3117 ± 96 2598 ± 84 U16845_at RNU16845 neurotrimin 0.00001 1476 ± 20 1244 ± 45 979 ± 68 X78327_at Rpl13 ribosomal protein L13 0.00067 13340 ± 474 15882 ± 498 12879 ± 478 X94242_at Rpl14 ribosomal protein L14 0.00034 4257 ± 108 5585 ± 125 4942 ± 233 rc_AA817997_at Rpl24 ribosomal protein L24 0.01968 13045 ± 290 14293 ± 242 12683 ± 477 rc_AI103236_at Rpl35a ribosomal protein L35a 0.00087 10583 ± 255 10575 ± 273 8288 ± 556 M17419_at Rpl5 ribosomal protein L5 0.00102 20061 ± 461 21996 ± 417 19239 ± 452 X05300_at Rpn1 Ribophorin I 0.00167 5752 ± 139 5744 ± 115 5147 ± 108 rc_AI014087_at Rps26 ribosomal protein S26 0.00063 20853 ± 736 25427 ± 849 22259 ± 503 X53377cds_s_at Rps7 ribosomal protein S7 0.01561 15233 ± 317 15199 ± 366 13890 ± 350 E12625cds_at Sc4mol sterol-C4-methyl oxidase-like 0.00002 5360 ± 233 6892 ± 169 6299 ± 115 rc_AI172293_at Sc4mol sterol-C4-methyl oxidase-like 0.00206 11135 ± 229 12372 ± 221 11189 ± 237 D89655_at Scarb1 scavenger receptor class B, member 1 0.00122 1031 ± 42 954 ± 47 790 ± 36 rc_AA874843_s_at Scarb1 scavenger receptor class B, member 1 0.00598 1779 ± 191 1963 ± 97 1233 ± 148 J02585_at Scd1 stearoyl-Coenzyme A desaturase 1 0.00117 1086 ± 27 1035 ± 41 879 ± 36 X99338cds_i_at Sdfr1 stromal cell derived factor receptor 1 0.00366 13279 ± 546 12973 ± 687 10567 ± 469 U25264_at Sepw1 Selenoprotein W muscle 1 0.00010 14033 ± 393 12675 ± 423 11429 ± 221 U90261UTR#1_g_at Sh3kbp1 SH3-domain kinase binding protein 1 0.00072 9716 ± 248 10838 ± 431 8878 ± 232 AF008439_g_at Slc11a2 solute carrier family 11 member 2 0.00000 3894 ± 99 3369 ± 146 2625 ± 66 L46873_s_at Slc15a1 solute carrier family 15 (oligopeptide transporter), member 1 0.00928 115 ± 10 186 ± 33 94 ± 11 X80395cds_s_at Slc18a3 solute carrier family 18, member 3 0.02911 461 ± 32 665 ± 81 488 ± 37 AF038571_s_at Slc1a1 solute carrier family 1, member 1 0.00284 3246 ± 132 3565 ± 120 2861 ± 126 rc_AA892776_at Slc25a3 solute carrier family 25, member 3 0.03510 17039 ± 1009 17782 ± 64 15465 ± 442 D12771_s_at Slc25a5 solute carrier family 25, member 5 0.01489 13231 ± 377 14604 ± 502 13143 ± 181 M96601_at Slc6a6 solute carrier family 6, member 6 0.00387 798 ± 44 778 ± 54 564 ± 48 AB017170_s_at Slit1 slit homolog 1 (Drosophila) 0.01937 971 ± 46 995 ± 39 847 ± 30 AB011531_at Slit3 slit homolog 3 (Drosophila) 0.00149 1281 ± 87 1554 ± 88 1109 ± 54 K02248cds_s_at Sst somatostatin 0.00000 6981 ± 298 5581 ± 306 4319 ± 116 M93273_at Sstr2 2 0.00001 1289 ± 28 1365 ± 65 982 ± 36 Y15068_at Stip1 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) 0.00003 4108 ± 161 4840 ± 133 3557 ± 150 AJ001529cds_at Stk3 serine/threonine kinase 3 0.00006 314 ± 20 457 ± 16 388 ± 15

Page 13 Supplementary Table 1: Calcineurin-Sensitive Genes

Probe Set Symbol Title ANOVA Uninfected Ad-LacZ Ad-aCaN D10392_i_at Stx1a 1a 0.00664 13290 ± 288 13652 ± 285 12259 ± 293 J03621_at Suclg1 succinate-CoA ligase, GDP-forming, alpha subunit 0.00016 4179 ± 210 4062 ± 97 3186 ± 130 L05435_at Sv2a glycoprotein 2 a 0.00045 2313 ± 71 2645 ± 120 2008 ± 88 rc_AI639484_at Sv2b synaptic vesicle glycoprotein 2 b 0.00582 9966 ± 171 10296 ± 138 9235 ± 266 L42855_at TCEB2 transcription elongation factor B (SIII) polypeptide 2 0.01315 16058 ± 597 17585 ± 779 14787 ± 478 rc_AA859980_g_at Tcp1 T-complex 1 0.00307 11008 ± 362 11241 ± 334 9642 ± 275 L25785_at Tgfb1i4 Transforming growth factor beta stimulated clone 22 0.00770 18222 ± 443 20847 ± 568 18938 ± 524 rc_AA874848_s_at Thy1 Thymus cell surface antigen 0.00000 11708 ± 589 7482 ± 277 5927 ± 232 AB006450_at Timm17a translocator of inner mitochondrial membrane 17a (yeast) 0.00004 3446 ± 123 4936 ± 121 4292 ± 212 U50194_at Tpp2 tripeptidylpeptidase II 0.01840 2744 ± 82 3139 ± 122 2699 ± 109 X68101_at trg 0.02089 4433 ± 96 4567 ± 105 4193 ± 72 AB015946_s_at Tubg1 , gamma 1 0.00753 1426 ± 66 1371 ± 42 1176 ± 52 D10699_g_at Uchl1 carboxy-terminal hydrolase L1 0.00651 17019 ± 1007 20293 ± 467 18190 ± 321 U87305_at Unc5h1 transmembrane receptor Unc5H1 0.00000 889 ± 70 829 ± 62 456 ± 9 X02341cds_at Vip vasoactive intestinal polypeptide 0.00001 374 ± 17 307 ± 17 238 ± 10 AF033027_at Ykt6 prenylated SNARE protein 0.00001 1422 ± 51 1834 ± 54 1415 ± 44 rc_AA924084_at Ywhab tyrosine 3-monooxgenase/tryptophan 5 monooxgenase protein, beta 0.00046 2290 ± 39 2409 ± 65 2047 ± 57 D17445_at Ywhah Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta 0.02979 11357 ± 234 11793 ± 412 10556 ± 280 AF054586_at Znf179 zinc finger protein 179 0.03101 2706 ± 223 3188 ± 171 2497 ± 135

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