SUPPLEMENTARY DATA Supplementary Figure S1. Subject

SUPPLEMENTARY DATA

Supplementary Figure S1. Subject disposition.

Percentages are based on randomized participants. The trial was initiated 25 November 2013, total trial duration was 58 weeks and consisted of a 2-week screening period, a dose initiation and escalation period of 2−4 weeks, a maintenance period of 48−52 weeks (dependent on dose/dose escalation scheme) and a 4-week follow-up period. The trial was completed 04 June 2015. n: number of participants

Supplementary Table S1. Baseline demographics of C-peptide-positive subjects.

Liraglutide Liraglutide Liraglutide Placebo

0.6mg 1.2mg 1.8mg N=51 Female (N, %) 31 (53.4) 23 (41.1) 32 (43.2) 26 (51.0) Age (years) (mean, SD) 42.6 (13.7) 45.0 (15.0) 44.4 (14.1) 43.5 (13.3) Body weight (kg) (mean, SD) 87.4 (18.1) 90.1 (17.9) 90.0 (17.6) 90.6 (18.1)

HbA1c (%) (mean, SD) 8.03 (0.790) 8.16 (0.725) 8.24 (0.911) 8.16 (0.719)

HbA1c (mmol/mol) (mean, SD) 64.3 (8.6) 65.8 (8.0) 66.6 (9.9) 65.8 (7.9) Duration of diabetes (years) (mean, SD) 12.9 (9.2) 13.4 (10.5) 13.4 (10.4) 10.9 (7.9) Fasting C-peptide serum (nmol/L) (geometric mean, CV) 0.15 (119.76) 0.13 (148.42) 0.11 (126.61) 0.13 (141.10) Fasting plasma glucose (mmol/L) (mean, SD) 10.38 (3.075) 11.10 (3.613) 10.40 (3.892) 9.77 (3.193) Hypoglycemic awareness; Yes (N, %) 56 (96.6) 54 ( 96.4) 68 (91.9) 49 (96.1) Any severe hypoglycemic episode within the last year; Yes 0 (0.0) 2 (3.6) 5 (6.8) 1 (2.0) (N, %) CSII (N, %) 13 (22.4) 9 (16.1) 13 (17.6) 10 (19.6) CSII; total daily insulin dose (U). Geometric mean (CV) 60.73 (49.44) 50.84 (50.91) 68.93 (47.57) 41.05 (53.23) MDI: total daily insulin dose (U). Geometric mean (CV) 63.45 (68.62) 69.45 (61.60) 61.21 (44.07) 68.74 (46.34)

CSII, continuous subcutaneous insulin infusion; CV, coefficient of variation; HbA1c, glycated hemoglobin; MDI, multiple dose injection; SD, standard deviation

Supplementary Figure S2.

Panel A. Change in FPG (mmol/L) by treatment week. On-treatment analysis. Group mean estimates (±SEM) are from a mixed model for repeated measurements with treatment, stratification and country as fixed factors, and baseline value as a fixed covariate, all nested within visit.

Panel B. Change in mean of 9-point SMPG (mmol/L) by treatment week. On-treatment analysis. Group mean estimates (±SEM) are from a mixed model for repeated measurements with treatment, stratification and country as fixed factors, and baseline value as a fixed covariate, all nested within visit.

Panel C. Change in 1,5-AG (ug/mL) by treatment week. On-treatment analysis. Group mean estimates (±SEM) are from a mixed model for repeated measurements on the log-transformed post-baseline responses with treatment, stratification and country as fixed factors, and baseline value as a fixed covariate, all nested within visit. Group mean estimates are adjusted according to the observed baseline distribution and back transformed to the original scale. Error bars are calculated on the log scale before being back transformed to original scale.

1,5-AG, 1,5-anhydroglucitol; BL, baseline; FPG, fasting plasma glucose; Lira, liraglutide; SEM, standard error of the mean; SMPG, self-measured plasma glucose profile

Supplementary Table S2. Treatment differences in FPG, SMPG and 1,5-AG after 52 weeks.

Liraglutide 1.8 mg Liraglutide 1.2 mg Liraglutide 0.6 mg 95% CI p-value 95% CI p-value 95% CI p-value FPG* -0.12 [-0.82; 0.59] 0.7488 -0.31 [-1.01; 0.40] 0.3969 0.28 [-0.40; 0.96] 0.4140 SMPG* 0.47 [0.12; 0.81] 0.0080 0.15 [-0.19; -0.49] 0.3940 0.23 [-0.10; 0.56] 0.1771 1,5-AG** 1.07 [0.99; 1.16] 0.0966 1.03 [0.95; 1.11] 0.4927 1.01 [0.94; 1.09] 0.7696 *ETD compared to placebo in FPG and mean of 9-point SMPG after 52 weeks. **ETR compared to placebo for 1,5-AG after 52 weeks. 1,5-AG, 1,5-anhydroglucitol; CI, confidence interval; ETD, estimated treatment differences; ETR, estimated treatment ratio; FPG, fasting plasma glucose; SMPG, self-measured plasma glucose

Supplementary Table S3. Event adjudication committee (EAC)-confirmed pancreatitis.

The participant was randomized to 0.6mg liraglutide and had the following medical history: duration of type 1 diabetes of 37 years, diabetic retinopathy, diabetic nephropathy, hypertension, hyperlipidemia, hay fever, vitamin D insufficiency, and never smoked. At 144 days after start of treatment with trial product, the participant was hospitalized due to acute central abdominal pain, which radiated to the back. The participant reported that the pain did not increase after eating, and that there was no vomiting, fever or rapid pulse. Cardiac investigations were without abnormal findings. An abdominal ultrasound was performed and no intra-abdominal pathology detected. Computed tomography of the abdomen and pelvis noted appearances compatible with pancreatitis. C-reactive protein was 31.0 mg/L (reference range: 0-8 mg/L). Lipase was 25 U/L (reference range: 0-60 U/L). Four preferred terms were reported covering the event (‘pancreatitis, ‘abdominal pain’, ‘back pain’ and ‘nausea’), all assessed as possibly related to trial product by the investigator. The participant was withdrawn from the trial due to the acute pancreatitis and recovered.

Supplementary Table S4. Summary of EAC-confirmed cases of diabetic ketoacidosis.

Duration of event Latest HbA value Baseline C-peptide Treatment group SAE/Severity 1c (days) before event level Liragutide 1.8 mg Subject 1a 3 Y/Moderate 7.6%

Supplementary Table S5. Summary of hyperglycemia with ketosis by baseline C-peptide (

Liraglutide 1.8 mg Liraglutide 1.2 mg Liraglutide 0.6 mg Placebo

N % E R N % E R N % E R N % E R

%, percentage of participants experiencing at least one event; E, number of events; LLOQ, lower limit of quantification for baseline C-peptide (0.03 nmol/L); N, number of participants experiencing at least one event; R, event rate per year of exposure

Supplementary Figure S3. Change in HbA1c (%) by treatment week and baseline C-peptide (

Supplementary Table S6. Change in HbA1c (%) by baseline C-peptide (

Liraglutide 1.8mg Liraglutide 1.2mg Liraglutide 0.6mg N N N 95% CI p-value 95% CI p-value 95% CI p-value Estimate Estimate Estimate Treatment difference (Liraglutide – placebo) C-peptide

C-peptide ≥LLOQ 56 -0.44 [-0.74; -0.15] 55 -0.32 [-0.62; -0.02] 72 -0.03 [-0.31; 0.25]

Test for treatment by 0.0754 0.2164 0.6296 subgroup interaction On treatment analysis. Post-baseline responses are analysed using a mixed model for repeated measurements with treatment, C-peptide, stratification and country as fixed factors, and baseline value as a fixed covariate. The model also includes the interaction between C-peptide and treatment, and the interactions between each model term and visit. Group mean estimates are adjusted according to the observed baseline distribution in each C-peptide subgroup.

CI, confidence interval; HbA1c, glycated hemoglobin; LLOQ, lower limit of quantification (0.03 nmol/L); N, number of liraglutide-treated subjects contributing to the analysis (for the placebo group, N=272 [C-peptide

Supplementary Table S7. Summary of symptomatic hypoglycemia by baseline C-peptide (

Liraglutide 1.8 mg Liraglutide 1.2 mg Liraglutide 0.6 mg Placebo

N % E R N % E R N % E R N % E R

%, percentage of subjects with at least one event (episode); ADA, American Diabetes Association; E, number of events (episodes); LLOQ, lower limit of quantification (0.03 nmol/L); N, number of subjects with at least one event (episode); R, event rate per subject year of exposure

Supplementary Table S8. Number of symptomatic hypoglycemic episodes by baseline C-peptide (

Liraglutide 1.8mg Liraglutide 1.2mg Liraglutide 0.6mg Estimate 95% CI p-value Estimate 95% CI p-value Estimate 95% CI p-value Event rate ratio (Liraglutide/placebo)

C-peptide

ADA, American Diabetes Association; CI, confidence interval; LLOQ, lower limit of quantification (0.03 nmol/L)

Supplementary Table S9. Mean HbA1c (%) at baseline for baseline HbA1c subgroups <8.5% and ≥8.5%.

Liraglutide 1.8 mg Liraglutide 1.2 mg Liraglutide 0.6 mg Placebo

HbA1c <8.5% Number of subjects 235 230 236 234

Mean HbA1c (%) 7.7 7.7 7.8 7.7 Standard deviation 0.4 0.5 0.4 0.4

HbA1c ≥8.5% Number of subjects 111 116 114 113

Mean HbA1c (%) 9.0 9.0 9.0 9.0 Standard deviation 0.4 0.5 0.5 0.4

HbA1c, glycated hemoglobin

Supplementary Table S10. Change in HbA1c by baseline HbA1c (<8.5% and ≥8.5).

Liraglutide 1.8mg Liraglutide 1.2mg Liraglutide 0.6mg N Estimate 95% CI p-value N Estimate 95% CI p-value N Estimate 95% CI p-value Treatment difference (Liraglutide – placebo) Baseline HbA1c <8.5 210 -0.21 [-0.36; -0.07] 204 -0.18 [-0.33; -0.03] 228 -0.08 [-0.23; 0.06]

Baseline HbA1c ≥8.5 95 -0.15 [-0.37; 0.07] 108 - 0.09 [-0.30; 0.12] 106 -0.10 [-0.31; 0.10] Test for treatment by 0.6426 0.4626 0.8789 subgroup interaction On-treatment analysis. Post-baseline responses are analysed using a mixed model for repeated measurements with treatment, stratification and country as fixed factors, and baseline value as a fixed covariate. The model also includes the interaction between HbA1c and treatment, and the interactions between each model term and visit. Group mean estimates are adjusted according to the observed baseline distribution in each HbA1c subgroup.

Supplementary Table S11. List of investigators.

ARGENTINA Primary Investigator City Centre CENUDIAB Alejandra Oviedo Buenos Aires CENUDIAB Martha Calveyra Buenos Aires CENUDIAB Veronica Geronazzo Buenos Aires Inst. Clínica Guillermo Rodriguez Mendoza Méd. y Diabetes Inst. Clínica Alejandra Cicchitti Mendoza Méd. y Diabetes Inst. Clínica Joaquin Gonzalez Mendoza Méd. y Diabetes Hospital Josefina Pozzo Buenos Aires Aleman Hospital Maria Lozano Buenos Aires Aleman Hospital Maria Rey Buenos Aires Aleman Hospital Maria Ridruejo Buenos Aires Aleman IME Claudia Lamela Buenos Aires IME Maria Moisello Buenos Aires IME Patricia Castaño Buenos Aires Hospital Luis De Loredo Córdoba Privado Hospital María Cismondi Córdoba Privado Hospital Mariana Burgos Córdoba Privado Hospital Santiago De Loredo Córdoba Privado Hospital S Da Luz Córdoba Privado Hospital Milena Suppo Córdoba Privado CIAD Cecilia Heredia Buenos Aires CIAD Sonia Hermida Buenos Aires CIAD G Gili Buenos Aires CIAD Virginia Visco Buenos Aires

AUSTRALIA Primary Investigator City Centre DON Christy Sankoorikal Broadmeadow DON Thomas Donnelly Broadmeadow SAER Anthony Roberts Keswick

AUSTRALIA Primary Investigator City Centre SAER Jui Ho Keswick ALF A/Duncan Topliss Melbourne ALF Kavita Melbourne Kumareswaran RMH Peter Colman Melbourne LMH Parind Vora Elizabeth Vale LMH Peak Mann Mah Elizabeth Vale

BELGIUM Primary Investigator City Centre UZ GHB Katrien Benhalima Leuven UZ GHB Pieter Gillard Leuven UZ GHB Chantal Mathieu Leuven UZA Frida Peiffer Edegem UZA Christophe De Block Edegem UZA Luc Van Gaal Edegem Cliniques du Eric Weber Arlon Sud- Luxembourg Cliniques du Vincent Ers Arlon Sud- Luxembourg CHU de Liège Bernard Jandrain Liège CHU de Liège Nicolas Paquot Liège CHU de Liège André Scheen Liège

CANADA Primary Investigator City Centre IUCPQ Claude Garceau Québec IUCPQ Francois Dube Québec IUCPQ Isabelle Kirouac Québec IUCPQ Isabelle Labonte Québec IUCPQ Kathleen Raby Québec IUCPQ Sylvain Chouinard Québec Credit Valley Alice Cheng Mississauga Endo Research Credit Valley Irving Gottesman Mississauga Endo Research Credit Valley Vladimir Milosevic Mississauga Endo Research Credit Valley W. John Langlois Mississauga

CANADA Primary Investigator City Centre Endo Research St. Michael's Amir Hanna Toronto Hospital St. Michael's Andrew Advani Toronto Hospital St. Michael's Lawrence Leiter Toronto Hospital St. Michael's Robert Josse Toronto Hospital Joanne Liutkus Joanne Liutkus Cambridge Joanne Liutkus Phoebe Bishara Cambridge Joanne Liutkus Robert Harvey Cambridge IRCM Hortensia Mircescu Montréal IRCM Remi Rabasa-Lhoret Montréal Alberta Elizabeth Edmonton Diabetes Rosolowsky Institute Alberta Jennifer Jacquier Edmonton Diabetes Institute Alberta Peter Senior Edmonton Diabetes Institute Alberta Tammy McNab Edmonton Diabetes Institute Bruno St-Pierre Bruno St-Pierre Sherbrooke Bruno St-Pierre Chantal Godin Sherbrooke CHU de Martin D'Amours Quebec Quebec- Universite Laval CHU de Stanley Weisnagel Quebec Quebec- Universite Laval CHU de Stanley Weisnagel Quebec Quebec- Universite Laval Winnipeg Carmen Hurd Winnipeg Regional Health Authority Winnipeg Vincent Woo Winnipeg Regional Health Authority Mount Sinai Bernard Zinman Toronto Hospital Mount Sinai Bruce Perkins Toronto Hospital LMC Toronto Adam Telner Toronto

CANADA Primary Investigator City Centre LMC Toronto Andrew Boright Toronto LMC Toronto Loren Grossman Toronto LMC Toronto Oren Steen Toronto LMC Toronto Ronnie Aronson Toronto LMC Toronto Samantha Sandler Toronto Hani Alasaad Suzan Abdel-Salam Barrie LMC Robert Schlosser Thornhill LMC Ronald Goldenberg Thornhill LMC David Twum- Oakville Barima LMC Sam Farah Oakville

FINLAND Primary Centre Investigator City FinnMedi Jorma Lahtela Tampere FinnMedi Päivi Hannula Tampere Laakso sairaala Nina Uhlenius Helsinki

Satakunta Pirkko Korsoff Pori Satakunta Taina Salmela- Pori Mattila Turun Lassi Nelimarkka Turku Yliopistollinen keskussairaala Turun Minna Soinio Turku Yliopistollinen keskussairaala HUS/Nefrologian Kim Pettersson- Helsinki klinikka Fernholm Seinäjoen Kari Väisänen Seinäjoki keskussairaala Seinäjoen Suvi Hietaniemi Seinäjoki keskussairaala

FRANCE Primary Investigator City Centre C.H.G. de Elie Aboud Narbonne Narbonne C.H.G. de Helene Bonnaure Narbonne Narbonne C.H.G. de Jean-Francois Thuan Narbonne Narbonne

FRANCE Primary Investigator City Centre C.H.G. de Jean Michel Andrieu Narbonne Narbonne C.H.G. de Jean-Pierre Narbonne Narbonne Courreges Hôpital Jean Annie Clergeot Besançon Minjoz Hôpital Jean Sophie Borot Besançon Minjoz Hôpital Jean Michel Grandmottet Besançon Minjoz Hôpital Jean Alfred Penfornis Besançon Minjoz Chu Du Bocage Benjamin Bouillet Dijon Chu Du Bocage Elodie Crevisy Dijon Chu Du Bocage Geneviève Vaillant Dijon Chu Du Bocage Ivan Belleville Dijon Chu Du Bocage Jean-Michel Petit Dijon Chu Du Bocage Marana Habchi Dijon Chu Du Bocage Marie-Claude Dijon Brindisi Chu Du Bocage Maud Beacco Dijon Chu Du Bocage Perrine Buffier Dijon Chu Du Bocage Sabine Baillot- Dijon Rudoni Chu Du Bocage Bruno Verges Dijon GHM Portes du Aurelie Decaudain Vénissieux Sud GHM Portes du Chantal Bully Vénissieux Sud GHM Portes du Elisabeth Drevard Vénissieux Sud GHM Portes du Kader Djebabra Vénissieux Sud GHM Portes du Pierre Serusclat Vénissieux Sud Hôpital Nord Laurence Floch Saint-Herblain Laënnec Hôpital Nord Vincent Jacquin Saint-Herblain Laënnec Hôpital Nord Bertrand Cariou Saint-Herblain Laënnec Fondation Louis Labbe Le Creusot Hôtel-Dieu Fondation Sylvaine Clavel Le Creusot Hôtel-Dieu Fondation Stéphanie Tracol Le Creusot Hôtel-Dieu

FRANCE Primary Investigator City Centre CHU Claude Gruel Pointe à Pitre CHU Jean-Paul Donnet Pointe à Pitre CHU Miro Popescu Pointe à Pitre CHU Sonia Benabdallah Pointe à Pitre CHSF Catherine Petit Corbeil-Essonnes CHSF Guillaume Corbeil-Essonnes Charpentier Chu Cote De Anne Rod Caen Nacre Chu Cote De Julie Morera Caen Nacre Chu Cote De Michael Joubert Caen Nacre Chu Cote De Yves Reznik Caen Nacre Hopital De La Emmanuel Sonnet Brest Cavale Blanche Hopital De La Nathalie Roudaut Brest Cavale Blanche Hopital De La P Monguillon Brest Cavale Blanche Hopital De La Véronique Kerlan Brest Cavale Blanche Hôpital Bichat Florence Travert Paris Hôpital Bichat Michel Marre Paris Hôpital Bichat Ronan Roussel Paris Hopital Nord Bogdan Galusca Saint-Priest-en-Jarez Hopital Nord Luc Millot Saint-Priest-en-Jarez Hopital Nord Lyadh Khalfallah Saint-Priest-en-Jarez Hopital Nord Natacha Germain Saint-Priest-en-Jarez Hopital Nord Bruno Estour Saint-Priest-en-Jarez CHU de Poitiers Pierre-Jean Saulnier Poitiers

CHU de Poitiers Samy Hadjadj Poitiers CHU de Poitiers Richard Marechaud Poitiers

GERMANY Primary Centre Investigator City Herrmann-Rinke, Anja Rinke Marburg Marburg Herrmann-Rinke, Christine Herrmann- Marburg Marburg Rinke Marck, Pohlheim Cornelia Marck Pohlheim Marck, Pohlheim Markus Pickel Pohlheim Paschen, Hamburg Bernd-M. Scholz Hamburg

GERMANY Primary Centre Investigator City Paschen, Hamburg Björn Paschen Hamburg Paschen, Hamburg Petra Kümmel Hamburg Rose, Münster Dirk Lammers Münster Rose, Münster Harald Pohlmeier Münster Rose, Münster Ludger Rose Münster Gemeinschaftspraxis Desiree Braun St. Ingbert-Oberwuerzbach Segner & Braun Gemeinschaftspraxis Alexander Segner St. Ingbert-Oberwuerzbach Segner & Braun Schlecht, Eisenach Katja Fleischmann Eisenach Schlecht, Eisenach Karin Schlecht Eisenach Gemeinschaftspraxis Andreas Klinge Hamburg für Innere Medizin Gemeinschaftspraxis Dominik Dahl Hamburg für Innere Medizin Gemeinschaftspraxis Katharina Gaede Hamburg für Innere Medizin Gemeinschaftspraxis Ulrich Wendisch Hamburg für Innere Medizin Wenzl-Bauer, Josef Wenzl Rehlingen-Siersburg Rehlingen-Siersb. Wenzl-Bauer, Veronika Wenzl- Rehlingen-Siersburg Rehlingen-Siersb. Bauer

IRELAND Primary Investigator City Centre Mater Ali Hameed Dublin Misericordiae Hospital Mater Hafiz Muhhammad Dublin Misericordiae Zia Ul Hussnain Hospital Mater Maria Byrne Dublin Misericordiae Hospital Mater Najia Siddique Dublin Misericordiae Hospital Mater Saad Abdulghafour Dublin Misericordiae Hospital Connolly Tommy Tun Blanchardstown Hospital Blanchardstown Connolly Ultan Healy Blanchardstown Hospital

IRELAND Primary Investigator City Centre Blanchardstown Connolly Seamus Sreenan Blanchardstown Hospital Blanchardstown Beaumont Diarmuid Smith Dublin Hospital Beaumont Hannah Forde Dublin Hospital CRC St. Aftab Khattak Dublin Vincent's CRC St. Aftab Khattak Dublin Vincent's CRC St. Gaoatswe Dublin Vincent's Gadintshware CRC St. Donal O'Shea Dublin Vincent's Galway CRF Aaron Liew Galway Galway CRF Aonghus O'Loughlin Galway Galway CRF Conall Dennedy Galway Galway CRF Timothy O'Brien Galway

ISRAEL Primary Investigator City Centre Hadassah Ein Ofri Mosenzon Jerusalem Karem Hadassah Ein Marina Potekhin Jerusalem Karem Hadassah Ein Itamar Raz Jerusalem Karem Schneider Ariel Tenenbaum Petah Tikva Children's MC. Schneider Avivit Brener Petah Tikva Children's MC. Schneider Liat De-Vries Petah Tikva Children's MC. Schneider Rachel Bello Petah Tikva Children's MC. Schneider Revital Nimri Petah Tikva Children's MC. Schneider Shlomit Shalitin Petah Tikva Children's MC. Schneider Tal Ben Ari Petah Tikva Children's MC. Schneider Yael Gazit Petah Tikva Children's MC.

ISRAEL Primary Investigator City Centre Schneider Yael Lebenthal Petah Tikva Children's MC. Schneider Liora Lazar Petah Tikva Children's MC. Schneider Moshe Phillip Petah Tikva Children's MC. Rambam MC - Nehama Zuckerman- Haifa Children A Levin Rambam MC - Oz Mordechai Haifa Children A Rambam MC - Naim Shehadeh Haifa Children A Rambam MC - Smadar Shilo Haifa Children A Maccabi Health Josef Cohen Rishon Lezion Services-Diabet Maccabi Health Margarita Mashavi Rishon Lezion Services-Diabet Maccabi Health Vered Toskar Rishon Lezion Services-Diabet Wolfson MC Daniel Shpitz Holon Wolfson MC Dimitry Feldman Holon Wolfson MC Elena Zvulunov Holon Wolfson MC Irena Leibovitch Holon Wolfson MC Israel Hochman Holon Wolfson MC Issac Bar-or Holon Wolfson MC Julio Wainstein Holon Wolfson MC Lea Chananashvili Holon Wolfson MC Yosefa Bar-Dayan Holon Wolfson MC Yulian Tilis Holon Endocrinology Anat Tsur Jerusalem Clalit Jerusalem Endocrinology Arin Hag Yahia Jerusalem Clalit Jerusalem Endocrinology Asher Corcos Jerusalem Clalit Jerusalem Endocrinology Muriel Metzger Jerusalem Clalit Jerusalem Endocrinology Odile Cohen- Jerusalem Clalit Jerusalem Ouaknine Endocrinology Ofa Makhoul Jerusalem Clalit Jerusalem Endocrinology Susan Chayen Jerusalem Clalit Jerusalem Endocrinology Victoria Terletsky Jerusalem Clalit Jerusalem

NETHERLANDS Primary Centre Investigator City UMC St. Evertine Abbink- Nijmegen Radboud Zandbergen UMC St. C.J. Tack Nijmegen Radboud MCH loc. P.H.L.M. Geelhoed- Den Haag Westeinde Duijvestijn MCH loc. Solrun Johannsson- Den Haag Westeinde Vidarsdóttir Bethesda diab. A. Kooy Hoogeveen research center Bethesda diab. Frank Huvers Hoogeveen research center Academisch Hans Romijn Amsterdam Medisch Centrum Academisch Maarten Soeters Amsterdam Medisch Centrum Academisch Samuel van Nierop Amsterdam Medisch Centrum VieCuri J.P.W. van den Venlo Bergh VieCuri Inge Boullart Venlo VieCuri R.Y. Velde Venlo Diabeter H.J. Aanstoot Rotterdam Diabeter Sarah Bovenberg Rotterdam

NORWAY Primary Centre Investigator City Stavanger John Cooper Stavanger Helseforskning Sykehuset Carl Tobias Hamar Innlandet HF Petersson Sykehuset Trine Finnes Hamar Innlandet HF Haukeland Eirik Søfteland Bergen Universitetssykehus Haukeland Hrafnkell Bergen Universitetssykehus Thordarson Haukeland Marianne Grytaas Bergen Universitetssykehus Haukeland Nevena Jovanovic Bergen Universitetssykehus Kongsvinger Jon Arne Sparby Kongsvinger Sykehus Bærum sykehus Rolf Whitfield Gjettum

NORWAY Primary Centre Investigator City Bærum sykehus Harald Smith Gjettum Bærum sykehus Øystein Husby Gjettum

POLAND Primary Investigator City Centre CenterMed Barbara Zmurowska Lublin CenterMed Ewa Szyprowska Lublin CenterMed Wojciech Lublin Szydlowski Prywatny Edyta Cichocka Zabrze Gabinet Prywatny Katarzyna Nabrdalik Zabrze Gabinet Prywatny Janusz Gumprecht Zabrze Gabinet Przychodnia dla Iwona Chorazy Warszawa Wojska SPZOZ Przychodnia dla Krystyna Warszawa Wojska SPZOZ Matuszewska Kat. i Klin. Pawel Piatkiewicz Warszawa Chorob Wew. i Dia Kat. i Klin. Malgorzata Bernas Warszawa Chorob Wew. i Dia Kat. i Klin. Malgorzata Bernat- Warszawa Chorob Wew. i Karpinska Dia Kat. i Klin. Krzysztof Warszawa Chorob Wew. i Markiewicz Dia Kat. i Klin. Roman Laz Warszawa Chorob Wew. i Dia Kat. i Klin. Ewa Jagielinska- Warszawa Chorob Wew. i Kalinowska Dia KO-MED Elzbieta Kramarczuk Zamość KO-MED Tomasz Mlynarski Zamość

RUSSIAN FEDERATION Primary Investigator City Centre Penza reg. hosp. Daria Kiseleva Penza Penza reg. hosp. Ekaterina Penza

RUSSIAN FEDERATION Primary Investigator City Centre Komissarova Penza reg. hosp. Irina Samylina Penza Penza reg. hosp. Olga Shimokhina Penza Penza reg. hosp. Marina Sergeeva- Penza Kondrachenko Saratov City Galina Saratov Clinical Hosp Znamenshchikova #9 Saratov City Elena Anikeeva Saratov Clinical Hosp #9 Saratov City Lubov Kargina Saratov Clinical Hosp #9 Saratov City Natalia Saratov Clinical Hosp Shatkovskaya #9 Saratov City Tatyana Rodionova Saratov Clinical Hosp #9 Emerg. hosp Anna Atamanova Volgograd #25 Emerg. hosp Oxana Korolik Volgograd #25 Emerg. hosp Ludmila Zarutskaya Volgograd #25 Kazan Elvira Bimerskaia Kazan Endocrinology Dispensary Kazan Irina Shalennaya Kazan Endocrinology Dispensary Kazan Radmila Mikhan Kazan Endocrinology Dispensary Kazan Svetlana Zyangirova Kazan Endocrinology Dispensary Kazan State Liliya Orlova Kazan Medical Academy Kazan State Farida Nasybullina Kazan Medical Academy Kazan State Gulmira Kashapova Kazan Medical Academy Kazan State Gulnar Vagapova Kazan

RUSSIAN FEDERATION Primary Investigator City Centre Medical Academy Kazan State Ludmila Kurshakova Kazan Medical Academy Kazan State Ludmila Sultanova Kazan Medical Academy

SWEDEN Primary Centre Investigator City Sahlgrenska Björn Eliasson Göteborg Universitetssjukhuset Sahlgrenska Christel Hero Göteborg Universitetssjukhuset Obesitascentrum/Medicinklin Ann-Sofie Bolmér Stockholm Obesitascentrum/Medicinklin Cecilia Tibell Stockholm Obesitascentrum/Medicinklin Joanna Stockholm Hemmingsson Skånes Universitets Sjukehus Bo Ahrén Malmö Skånes Universitets Sjukehus Christoffer Malmö Tengryd Skånes Universitets Sjukehus Johan Farngren Malmö Karolinska Johan Hoffstedt Stockholm Universitetssjukhuset Huddinge Karolinska Patrik Löfgren Stockholm Universitetssjukhuset Huddinge Karolinska Per Oskarsson Stockholm Universitetssjukhuset Huddinge

UKRAINE Primary Centre Investigator City IEM Olga Ozerianska Kyiv IEM Liubov Sokolova Kyiv IEM Andrij Efimov Kyiv IEM Mycola Tronko Kyiv EndoI-Kh Aleksandr Kharkiv Kholodnyi EndoI-Kh Anna Cherniaieva Kharkiv EndoI-Kh Nonna Kravchun Kharkiv EndoI-Kh Iurii Karachentsev Kharkiv

UKRAINE Primary Centre Investigator City Zhytomyr Reg Clin Iryna Shpilia Zhytomyr Hosp Zhytomyr Reg Clin Petro Kuskalo Zhytomyr Hosp Zhytomyr Reg Clin Tetiana Ishchenko Zhytomyr Hosp Zhytomyr Reg Clin Victoriya Zhytomyr Hosp Stakhovska UMSA- Albina Matiusha Poltava PoltRegClinHospital UMSA- Vitaliy Katerenchuk Poltava PoltRegClinHospital CEMDM Natalia Zaitseva Kharkiv CEMDM Olena Tkachuk Kharkiv CEMDM Ivan Smirnov Kharkiv

UNITED KINGDOM Primary Investigator City Centre Western Barbara Brett Edinburgh General Hospital Western John McKnight Edinburgh General Hospital Univ Dept of Beverley Millward Plymouth Med, Plymouth Univ Dept of Ann Millward Plymouth Med, Plymouth Univ Dept of J Stokes Plymouth Med, Plymouth Univ Dept of Mike Eaton Plymouth Med, Plymouth Univ Dept of Patrick English Plymouth Med, Plymouth Southmead Andrew Johnson Bristol Hospital Southmead Kathryn Lonnen Bristol Hospital Southmead Polly Bingley Bristol Hospital Ealing Hospital Kevin Baynes Middlesex Ealing Hospital Sanjeev Mehta Middlesex James Cook Uni Rasha Mukhtar Middlesborough Hospital James Cook Uni Ruth Todd Middlesborough Hospital

UNITED KINGDOM Primary Investigator City Centre James Cook Uni Stephen Jones Middlesborough Hospital James Cook Uni Rudolf Bilous Middlesborough Hospital St. Helens Kevin Hardy Merseyside Hospital St. Helens Niall Furlong Merseyside Hospital St. Helens Upendram Srinivas- Merseyside Hospital Shankar Queen Elizabeth P Narendran Birmingham Hospital Queen Elizabeth Sandip Ghosh Birmingham Hospital Royal Amar Ali Blackburn Blackburn Hospital Royal Khaled Tofeec Blackburn Blackburn Hospital Royal Shenaz Ramtoola Blackburn Blackburn Hospital University Hosp Kamal Abouglila Durham North Durham University Hosp Praveen Partha Durham North Durham Lister Hospital Adie Viljoen Stevenage Lister Hospital Les Borthwick Stevenage Lister Hospital Supriya Joshi Stevenage Lister Hospital Sumarie Viljoen Stevenage

UNITED STATES Primary Centre Investigator City Texas Diabetes & Lindsay Harrison Austin Endocrinology Texas Diabetes & Luis Casaubon Austin Endocrinology Texas Diabetes & Thomas Blevins Austin Endocrinology Texas Diabetes & Tira Chaicha-Brom Austin Endocrinology Texas Diabetes & Valerie Espinosa Austin Endocrinology Texas Diabetes & Louie Riesch Austin

UNITED STATES Primary Centre Investigator City Endocrinology Texas Diabetes & Alison Cooper Austin Endocrinology Texas Diabetes & Carrie Livingston Austin Endocrinology Texas Diabetes & Cortney Hance Austin Endocrinology Texas Diabetes & Lily Ahn Austin Endocrinology Texas Diabetes & Monica Cano Austin Endocrinology Texas Diabetes & Vankatesh Segu Austin Endocrinology Carolina Health Chad Huberty Myrtle Beach Specialists Carolina Health Donald Eagerton Myrtle Beach Specialists Carolina Health Maggi Hullett Myrtle Beach Specialists Carolina Health John Harrison Myrtle Beach Specialists Carolina Health Irena Ross Myrtle Beach Specialists Carolina Health Marina Shvarts Myrtle Beach Specialists University Physicians Jeffrey Rothman Staten Island Group University Physicians Neil Cohen Staten Island Group University Physicians Shahed Quyyumi Staten Island Group University Physicians Bridget Recker Staten Island Group University Physicians Cheryl Correll Staten Island Group University Physicians Jessica Edwin Staten Island Group Carl R. Meisner Carl Meisner Sugar Land Medical Clinic Carl R. Meisner Caroline Mbogua Sugar Land Medical Clinic Carl R. Meisner Rachid Alaoui Sugar Land Medical Clinic Carl R. Meisner Florence Toe Sugar Land Medical Clinic Medical James Thrasher Little Rock Investigations Inc. Medical Teresa Nimmo Little Rock Investigations Inc.

UNITED STATES Primary Centre Investigator City Medical Spencer Francis Little Rock Investigations Inc. Medical Amanda Stubbs Little Rock Investigations Inc. Medical Kimberly Little Rock Investigations Inc. Williamson Medical Lesa Thrasher Little Rock Investigations Inc. Partners In Patricia Bononi Pittsburgh Nephrology & Endoc Partners In Melissa Bain Pittsburgh Nephrology & Endoc Optimum Clinical Imran Zubair Salt Lake City Research, Inc Optimum Clinical Jackson Rhudy Salt Lake City Research, Inc AMCR Institute Inc Brandee Ibarra Escondido AMCR Institute Inc Chandrasekhar Escondido Varma AMCR Institute Inc Timothy Bailey Escondido AMCR Institute Inc Carmen Franco- Escondido Cline AMCR Institute Inc John Walsh Escondido AMCR Institute Inc Trent Davis Escondido AMCR Institute Inc Carmen Moscoa Escondido AMCR Institute Inc Laura Bedolla Escondido AMCR Institute Inc Roya Jannesari Escondido AMCR Institute Inc Yvonne Canedo Escondido AMCR Institute Inc Tracy McKay Escondido Aurora Advanced Rajeev Jain Milwaukee Healthcare Inc Aurora Advanced Debra Krasprzak Milwaukee Healthcare Inc Aurora Advanced Maurene Maaske Milwaukee Healthcare Inc Missouri Endocrine & Amin Radparvar St Peters Diabetes East Coast Inst for Rosalyn Alcalde Jacksonville Research/Baptist Crawford Endocrinology East Coast Inst for Wasim Deeb Jacksonville Research/Baptist Endocrinology East Coast Inst for Megan Minor Jacksonville Research/Baptist Endocrinology Diabetes And Kathryn Lucas Morehead City Endocrinology

UNITED STATES Primary Centre Investigator City Consultants Diabetes And Kristin Ferree Morehead City Endocrinology Consultants International Diabetes Glenn Matfin Minneapolis Center International Diabetes Richard Bergenstal Minneapolis Center International Diabetes Richard Bergenstal Minneapolis Center International Diabetes Elinor Strock Minneapolis Center International Diabetes Kathy McCann Minneapolis Center International Diabetes Marcia Madden Minneapolis Center Endocrine Research Cynthia Brown Roswell Solutions Endocrine Research John Reed Roswell Solutions Endocrine Research Miguel Munoz Roswell Solutions Endocrine Research Donni Jester Roswell Solutions Endocrine Research Jessica Tapia Roswell Solutions Endocrine Research Susie Estes Roswell Solutions Endocrine Research Tabby Sapp Roswell Solutions Michael L Reeves Michael Reeves Chattanooga Michael L Reeves Pamela Reeves Chattanooga John J Shelmet, MD John Shelmet Lawrenceville John J Shelmet, MD Billie Shelmet Lawrenceville Texas Diabetes & Kamalpreet Singh Round Rock Endocrinology Texas Diabetes & Kerem Ozer Round Rock Endocrinology Texas Diabetes & Stephanie Shaw Round Rock Endocrinology Texas Diabetes & Michelle Ulrich Round Rock Endocrinology Texas Diabetes & Jefferey Shirley Round Rock Endocrinology Texas Diabetes & Alison Cooper Round Rock Endocrinology Texas Diabetes & Amanda Bonazzi Round Rock Endocrinology Texas Diabetes & Desiree Warne Round Rock

UNITED STATES Primary Centre Investigator City Endocrinology Texas Diabetes & Lindsay Groce Round Rock Endocrinology Texas Diabetes & Oliva Johnson Austin Endocrinology NorCal Yshay Shlesinger San Ramon Endocrinology NorCal Svetlana Lisovskiy San Ramon Endocrinology Columbia University Carlos Lopez New York Medical Center Columbia University Daniel Donovan New York Medical Center Columbia University Rocky Tang New York Medical Center High Desert Medical Anthony Dulgeroff West Lancaster Group High Desert Medical Vincent Ho West Lancaster Group Albany Medical Gregg Gerety Albany College Albany Medical Carol Duma Albany College Albany Medical Susan Flaherty Albany College David Gorson, MD David Gorson Bennington Baylor Endocrine Erin Roe Dallas Center Baylor Endocrine Priscilla Hollander Dallas Center Baylor Endocrine Kristen Chionh Dallas Center Baylor Endocrine Kristy Schuh Dallas Center Baylor Endocrine Laurie Jones Dallas Center Baylor Endocrine Meghan Manley Dallas Center Mercy Medical Gregory Ledger Springfield Research Inst Mercy Medical Randall Robinson Springfield Research Inst Mercy Medical Christina Doing Springfield Research Inst Mercy Medical Jennifer Robertson Springfield Research Inst Mercy Medical Zella Holmes Springfield Research Inst Jellinger and Lerman, Sam Lerman Hollywood

UNITED STATES Primary Centre Investigator City MD, PA Jellinger and Lerman, Jose Garcia Hollywood MD, PA Jellinger and Lerman, Carrie-Ann Silvia Hollywood MD, PA Jellinger and Lerman, Maria Martin Hollywood MD, PA Jellinger and Lerman, Mary Kathryn Hollywood MD, PA Linear Jellinger and Lerman, Sharon Lamkin Hollywood MD, PA Mountain View Ronald Mayfield Greer Clinical Research Mountain View Thomas Ballard Greer Clinical Research Mountain View William Byars Greer Clinical Research Mountain View Bunny Phillips Greer Clinical Research Mountain View Denise Wood Greer Clinical Research Mountain View Jacqueline Saunders Greer Clinical Research Mountain View Kristy Smith Greer Clinical Research Mountain View Lina Lopez Greer Clinical Research Mountain View Nancy Durham Greer Clinical Research Mountain View Wendy Harrell Greer Clinical Research Mountain View Yolanda Livingston Greer Clinical Research Barry J Reiner, LLC Barry Reiner Baltimore Larry Stonesifer, MD Larry Stonesifer Federal Way Larry Stonesifer, MD Cindy Heins Federal Way Larry Stonesifer, MD Heather Baldwin Federal Way Larry Stonesifer, MD Marcia Miller Federal Way Larry Stonesifer, MD Tammy Lovie- Federal Way Yokum Your Diabetes Brian Burtch Mentor Endocrine Nutrition Group Your Diabetes Daniel Weiss Mentor Endocrine Nutrition Group Diabetes and Obesity Howard Baum Nashville Clinical Diabetes and Obesity Michael May Nashville

UNITED STATES Primary Centre Investigator City Clinical Diabetes and Obesity Connie Root Nashville Clinical Diabetes and Obesity Janet Myers Nashville Clinical Diabetes and Obesity Janie Lipps Nashville Clinical American Health Terry Ridge Indianapolis Network American Health Thomas Moretto Indianapolis Network American Health Karen Thomas Indianapolis Network Atlanta Diabetes Bruce Bode Atlanta Associates Atlanta Diabetes Jonathan Ownby Atlanta Associates Atlanta Diabetes Joseph Johnson Atlanta Associates University Diabetes & David Huffman Chattanooga Endocrine Consultants University Diabetes & Mandy Jones Chattanooga Endocrine Consultants MedPharmics, LLC Cori Favalora Metairie MedPharmics, LLC Paul Blomkalns Metairie MedPharmics, LLC Robert Jeanfreau Metairie MedPharmics, LLC Kristen Knight Metairie MedPharmics, LLC Andrea Jeanfreau Metairie MedPharmics, LLC Susan Tortorich Metairie MedPharmics, LLC Tim Slocum Metairie Washington C. Rachel Kilpatrick St. Louis University Washington Janet McGill St. Louis University International Cristian Breton Hialeah Research Associates International Luis Quintero Hialeah Research Associates International Noel Lezama Hialeah Research Associates International Gustavo Canelon, Hialeah Research Associates CRC International Juan Calderon Hialeah Research Associates International Yamilet Yuen Hialeah Research Associates

UNITED STATES Primary Centre Investigator City SSM Medical Group Jerome Thurman St Charles SSM Medical Group Dana Brantley St Charles SSM Medical Group Janice Woodson St Charles Strelitz Diabetes Aaron Vinik Norfolk Center Strelitz Diabetes Matthew Boucier Norfolk Center Strelitz Diabetes Carolina Casellini Norfolk Center Strelitz Diabetes Danielle Jones Norfolk Center West Broadway Diana Rabadi-Marar Council Bluffs Clinic West Broadway Isam Marar Council Bluffs Clinic Cotton O'Neil Clinical Alan Wynne Topeka Research Cotton O'Neil Clinical Gary Graf Topeka Research Cotton O'Neil Clinical Cathy Pritchard Topeka Research Cotton O'Neil Clinical Dawnya Horn Topeka Research Cotton O'Neil Clinical Linda Frazee Topeka Research Jedidiah Clinical Andrew Henry Tampa Research Jedidiah Clinical Patrick Watson Tampa Research Jedidiah Clinical Olayemi Claridge Tampa Research Jedidiah Clinical Oluwakemi Bakare Tampa Research Mercury Street Erin Williams-Leber Butte Medical Group, Mercury Street John Pullman Butte Medical Group, Rocky Mtn Diabetes Carl Vance Idaho Falls & Osteo Ctr Rocky Mtn Diabetes David Liljenquist Idaho Falls & Osteo Ctr Rocky Mtn Diabetes Jonathan Williams Idaho Falls & Osteo Ctr Rocky Mtn Diabetes Tiffany Coughenour Idaho Falls & Osteo Ctr Creekside Endocrine Howard Kerstein Denver Associates Creekside Endocrine Leonard Zemel Denver Associates

UNITED STATES Primary Centre Investigator City Sestron Clinical Barbara Biggs Marietta Research Sestron Clinical Glenn Gatipon Marietta Research Sestron Clinical Kathryn Collier Marietta Research Sestron Clinical Lance Walker Marietta Research Sestron Clinical Lisa Hollifield Marietta Research Sestron Clinical Linda Sweeney Marietta Research Sestron Clinical Sestilia Tirillo Marietta Research The Chandler Bronell Chandler Upper Darby &Thakur Medical Diabetes And Norman Fishman Chesterfield Endocrinology Specialists Diabetes And Maria Weir Chesterfield Endocrinology Specialists Diabetes And Rachel Fishman Chesterfield Endocrinology Oiknine Specialists Diabetes And Suzette Christopher Chesterfield Endocrinology Specialists Northside Internal Harold Cathcart Spokane Medicine Northside Internal Timothy Gardner Spokane Medicine Northside Internal Brandie Sevey Spokane Medicine Northside Internal Kami Halsey Spokane Medicine Diabetes And Chris Sadler La Mesa Endocrine Associates Diabetes And Raymond Fink La Mesa Endocrine Associates Diabetes And Daniel Einhorn La Mesa Endocrine Associates Diabetes And Denise Humphries La Mesa Endocrine Associates Sergio F Rovner, Benito Marranzini El Paso M.D. Sergio F Rovner, Sergio Rovner El Paso M.D. Sergio F Rovner, Verlaine Stewart- El Paso M.D. Ray

UNITED STATES Primary Centre Investigator City Billings Clinical Christopher Sorli Billings Research Cen Billings Clinical Kim Ackerman Billings Research Cen SUNY Upstate Roberto Izquierdo Syracuse Medical University SUNY Upstate Ruth Weinstock Syracuse Medical University Winthrop University Cindy Bredefeld Mineola Hospital Winthrop University Lauren Maiorini Mineola Hospital Winthrop University Lawrence Shapiro Mineola Hospital Winthrop University Mageda Mikhail Mineola Hospital Winthrop University Neha Bansal Mineola Hospital Winthrop University David Sionit Mineola Hospital Winthrop University Eileen Egan Mineola Hospital Winthrop University Marilyn Richardson Mineola Hospital Winthrop University Nazanin Barzideh Mineola Hospital Palmetto Clinical Colby Grossman Summerville Research Palmetto Clinical D. Eric Bolster Summerville Research Palmetto Clinical Suzann Weathers Summerville Research Palmetto Clinical Jessica Salamacha Summerville Research Laureate Medical Ibrez Bandukwala Atlanta Group Laureate Medical Jennifer Madden Atlanta Group Laureate Medical Kate Wheeler Atlanta Group Laureate Medical Morris Brown Atlanta Group Laureate Medical Scott Kleber Atlanta Group Laureate Medical Sekhar Ghosh Atlanta Group The Endocrine Clinic Alan Cohen Memphis The Endocrine Clinic Omid Rad Pour Memphis The Endocrine Clinic Richard Childress Memphis

UNITED STATES Primary Centre Investigator City The Endocrine Clinic Lily Rutledge Memphis The Endocrine Clinic Stacie Olivi Memphis St Joseph's / Candler Joseph Dehaven Savannah Health S Mount Sinai School Brett Ives New York of Medicine Mount Sinai School Camilla Levister New York of Medicine Mount Sinai School David Lam New York of Medicine Mount Sinai School Carol Levy New York of Medicine Mount Sinai School Deirdre Cocks- New York of Medicine Eschler Mount Sinai School Ronald Tamler New York of Medicine Mount Sinai School Cynthia Esrig New York of Medicine Mount Sinai School Joanna Lis New York of Medicine Mills-Peninsula David Klonoff San Mateo Health Service Mills-Peninsula Irina Nayberg San Mateo Health Service Mills-Peninsula Karen Aeschliman San Mateo Health Service Dallas Diabetes & Julio Rosenstock Dallas Endocrine Ce Dallas Diabetes & Salomon Banarer Dallas Endocrine Ce Dallas Diabetes & Allison Camacho Dallas Endocrine Ce Dallas Diabetes & Leslie Rooker- Dallas Endocrine Ce Morris, PA-C Dallas Diabetes & Lisa Mize Dallas Endocrine Ce Dallas Diabetes & Wendy Kniffen, PA- Dallas Endocrine Ce C Dallas Diabetes & Summer Oswald Dallas Endocrine Ce University Of Iowa Eva Tsalikian Iowa City Hospitals University Of Iowa Joanne Cabbage Iowa City Hospitals University Of Iowa Michael Tansey Iowa City Hospitals University Of Iowa Julie Coffey Iowa City Hospitals University Of Iowa Sarah Salamati Iowa City

UNITED STATES Primary Centre Investigator City Hospitals PharmQuest Alexander Murray Greensboro PharmQuest Randal Von Seggern Greensboro PharmQuest Stephen South Greensboro PharmQuest William Harris Greensboro PharmQuest Sherri Frazier Greensboro PharmQuest Sharon Debnam Greensboro Monterey Endocrine James Chu Monterey & Diabetes Medical Group Of Allan Klass Encino Encino Medical Group Of David Kayne Encino Encino Medical Group Of Marie Feldman Encino Encino Diabetes/Lipid Paul Rosenblit Huntington Beach Management & Diablo Clinical Helen Stacey Walnut Creek Research, Inc. Diablo Clinical Leonard Chuck Walnut Creek Research, Inc. Diablo Clinical Mark Christiansen Walnut Creek Research, Inc. Diablo Clinical Richard Weinstein Walnut Creek Research, Inc. Diablo Clinical Kristy Sunada Walnut Creek Research, Inc. Solutions Through Alan Cleland Jacksonville Advanced Res Solutions Through Rosalyn Crawford Jacksonville Advanced Res Solutions Through Wasim Deeb Jacksonville Advanced Res Solutions Through Lisa Thomas Jacksonville Advanced Res Solutions Through Megan Minor Jacksonville Advanced Res MidState Endocrine Terri Jerkins Nashville Associates MidState Endocrine Randy Jerkins Nashville Associates John Muir Physician Anna Chang Concord Network Cl John Muir Physician Douglas Zlock Concord Network Cl John Muir Physician Roy Kaplan Concord Network Cl North Texas Jonathan Leffert Dallas Endocrine Center

UNITED STATES Primary Centre Investigator City North Texas Peter Bressler Dallas Endocrine Center North Texas Alexandra Ramirez Dallas Endocrine Center North Texas Donna Flanders Dallas Endocrine Center North Texas Julia Dilliard Dallas Endocrine Center North Texas Michelle Katz Dallas Endocrine Center North Texas Susan Watkins Dallas Endocrine Center Amarillo Medical Leonard Dodson Amarillo Specialists Amarillo Medical Stephen Usala Amarillo Specialists Amarillo Medical William Biggs Amarillo Specialists Amarillo Medical Kenny Brantley Amarillo Specialists