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| Hai Lala at Matali Del Tema Ana Haiti |HAI LALA AT MATALIUS009951035B2 DEL TEMA ANA HAITI (12 ) United States Patent (10 ) Patent No. : US 9 , 951, 035 B2 Chang et al. (45 ) Date of Patent: * Apr . 24 , 2018 ( 54 ) SELECTIVE MATRIX 7 , 928 ,127 B2 4 /2011 Lee et al . 7 ,981 ,426 B2 7 / 2011 Kim METALLOPROTEINASE INHIBITORS 7 , 993 , 665 B2 8 / 2011 Colin et al. 8 , 012 , 947 B2 9 /2011 Tomic et al . @( 71 ) Applicant: University of Notre Dame du Lac, 8 , 093 , 287 B2 1 / 2012 Lee et al . South Bend , IN (US ) 8 , 129 , 341 B2 3 /2012 Gold et al . 8 , 247 , 384 B2 8 / 2012 Green et al . @( 72 ) Inventors : Mayland Chang, Granger , IN ( US ) ; 8 , 889 ,615 B2 11/ 2014 Tomic - Canic et al . 9 ,604 ,957 B2 * 3 / 2017 Chang . .. .. .. .. C07D 331/ 02 Shahriar Mobashery , Granger, IN 2002 / 0037916 A1 3 / 2002 Mobashery et al. ( US ) 2007 / 0232541 A1 10 / 2007 Reiter et al. 2009 /0068251 A1 3 /2009 Tomic et al. @( 73 ) Assignee : University of Notre Dame du Lac , 2011/ 0224275 AL 9 / 2011 Lee et al. South Bend , IN (US ) 2011 / 0293643 Al 12 / 2011 Wilkes 2012 / 0052110 A1 3 /2012 Tomic et al . ( * ) Notice : Subject to any disclaimer , the term of this 2013 / 0052184 Al 2 /2013 Chang et al. patent is extended or adjusted under 35 U . S . C . 154 ( b ) by 0 days. FOREIGN PATENT DOCUMENTS This patent is subject to a terminal dis WO 2006125208 AL 11 / 2006 WO 2010093607 AL 8 /2010 claimer . wo 2011026107 AL 3 / 2011 ( 21 ) Appl. No .: 15 / 469, 010 wo 2016044844 A1 3 / 2016 ( 22 ) Filed : Mar. 24 , 2017 OTHER PUBLICATIONS Armstrong et al. , “ The Role of Matrix Metalloproteinases in Wound (65 ) Prior Publication Data Healing " , Journal of the American Podiatric Medical Association , US 2017 /0190685 A1 Jul. 6 , 2017 vol . 92 , No. 1 , 2002 ; pp . 12 - 18 . Brown et al ., “ Potent and Selective Mechanism - Based Inhibition of Gelatinases ” , Journal of the American Chemical Society , vol. 122 , Related U . S . Application Data No . 28 ; Jun . 30 , 2000 ; pp . 6799 -6800 ; American Chemical Society . (63 ) Continuation of application No. 15 / 120 ,508 , filed as Chen et al. , “ Molecular and Mechanistic Validation of Delayed application No . PCT/ US2015 /016950 on Feb . 20 , Healing Rat Wounds as a Model for Human Chronic Wounds ” , Wound Repair and Regeneration , vol. 7 , No. 6 , Nov . 1999 , pp . 2015 , now Pat . No . 9 ,604 , 957 . 486 -494 ; The Wound Healing Society . (60 ) Provisional application No . 62 / 088, 380 , filed on Dec. Cui et al. , “ Inhibition of MMP - 9 by a Selective Gelatinase Inhibitor 5 , 2014 , provisional application No. 61/ 942 , 516 , filed Protects Neurovasculature from Embolic Focal Cerebral Ischemia ” , on Feb . 20 , 2014 . Molecular Neurodegeneration , vol. 7 , No . 21, 2012 , pp . 1 - 15 , BioMed Central Ltd . Fisher et al . , “ Recent Advances in MMP Inhibitor Design ” , Cancer ( 51 ) Int. Cl. and Metastasis Reviews, vol . 25 , 2006 , pp . 115 - 136 , Springer C070 331 /02 ( 2006 .01 ) Science and Business Media , LLC . CO7D 303 / 34 ( 2006 . 01 ) Forbes et al. , “ Active Site Ring -Opening of a Thiirane Moiety CO7D 413 / 12 ( 2006 .01 ) and Picomolar Inhibition of Gelatinases” , Chemical Biology & A61K 9 /00 ( 2006 . 01 ) Drug Design , vol. 74 , Aug . 2009 , pp . 527 - 534 , John Wiley & Sons A61K 31/ 38 ( 2006 .01 ) A / S . A61K 31/ 4245 ( 2006 .01 ) Gooyit et al. , " A Chemical Biological Strategy to Facilitate Diabetic (52 ) U .S . CI. Wound Healing" , ACS Chemical Biology 2014 , vol . 9 ; Sep . CPC . .. .. .. C070 331/ 02 ( 2013 .01 ) ; A61K 9 /0014 20 , 2013 ; pp . 105 - 110 ; ACS Publications, American Chemical (2013 .01 ) ; A61K 31/ 38 ( 2013 .01 ) ; A61K Society 31/ 4245 (2013 .01 ) ; C07D 303 / 34 ( 2013 .01 ) ; (Continued ) CO7D 413 / 12 (2013 . 01 ) (58 ) Field of Classification Search Primary Examiner — Matthew P Coughlin CPC . .. CO7D 331/ 02 ; CO7D 303 / 34 ( 74 ) Attorney , Agent, or Firm — Haukaas Fortius PLLC ; See application file for complete search history . Michael H . Haukaas ( 56 ) References Cited (57 ) ABSTRACT The invention provides compounds, compositions, and U . S . PATENT DOCUMENTS methods for the treatment of diseases , disorders , or condi 6 , 025 , 150 A 2 / 2000 Livant tions that are modulated by matrix metalloproteinases 6 , 166 ,084 A 12 / 2000 Bloor (MMPs ) . The compounds can be selective MMP inhibitors , 6 , 555 , 118 B1 4 / 2003 Niazi for example , selective inhibitors of MMP - 2 , MMP - 9 , and /or 6 , 600 , 057 B2 7 / 2003 Quirk MMP - 14 . The disease, disorder, or condition can include , 6 ,703 , 415 B2 3 / 2004 Mobashery et al. for example , stroke , neurological disorders , ophthalmologi 7 , 144 , 917 B2 12 / 2006 Mobashery et al . 7 , 320 , 783 B2 1 / 2008 Livant cal disorders , or wounds , such as chronic wounds or diabetic 7 ,402 , 571 B2 7 / 2008 Tennenbaum et al. wounds . 7 , 727, 520 B2 6 / 2010 Ferguson 7 , 879 , 798 B1 . 2 /2011 Aufseeser 19 Claims, 9 Drawing Sheets US 9 , 951 ,035 B2 Page 2 ( 56 ) References Cited Lee et al. , “Metabolism of a Highly Selective Gelatinase Inhibitor Generates Active Metabolite " , Chemical Biology & Drug Design , vol . 70 ; Sep . 2007 , pp . 371 -382 , Blackwell Munksgaard . OTHER PUBLICATIONS Lee et al. , " Structure - Activity Relationship for Thiirane - Based Gooyit et al. , “ O - Phenyl Carbamate and Phenyl Urea Thiiranes as Gelatinase Inhibitors” , ACS Medicinal Chemistry Letters , vol. 3 , Selective Matrix Metalloproteinase - 2 Inhibitors that Cross the May 2 , 2012 ; pp . 490 -495 ; ACS Publications, American Chemical Blood -Brain Barrier ” , Journal ofMedicinal Chemistry , vol . 56 , Sep . Society . 12 , 2013 , pp . 8139 - 8150 ; ACS Publications , American Chemical Pradhan et al. , “ Wound -Healing Abnormalities in Diabetes and New Society . Therapeutic Interventions” , Diabetic Foot, US Endocrine Disease , Gooyit et al. , " Selective Gelatinase Inhibitor Neuroprotective 2007 , pp . 68 - 72 , Touch Briefings . Agents Cross the Blood - Brain Barrier " , ACS Chemical Neurosci Song et al . , “ Water - Soluble MMP - 9 Inhibitor Prodrug Generates ence , vol. 3 , Jul . 30 , 2012 ; pp . 730 -736 ; ACS Publications, Ameri Active Metabolites That Cross the Blood - Brain Barrier” , ACS can Chemical Society. Chemical Neuroscience , vol. 4 ; May 20 , 2013 ; pp . 1168 - 1173 ; ACS Gooyit et al. , “ Selective Water -Soluble Gelatinase Inhibitor Publications, American Chemical Society. Prodrugs ” , Journal of Medicinal Chemistry , vol. 54 , Aug . 25 , 2011 ; Toth et al. , “ Tissue Inhibitor of Metalloproteinase ( TIMP) - 2 Acts pp . 6676 - 6690 ; ACS Publications, American Chemical Society . Synergistically with Synthetic Matrix Metalloproteinase (MMP ) Gu et al. , “ A Highly Specific Inhibitor of Matrix Metal loproteinase - 9 Rescues Laminin from Proteolysis and Neurons from Inhibitors but not with TIMP - 4 to Enhance the (Membrane Type Apoptosis in Transient Focal Cerebral Ischemia ” , The Journal of 1 ) -MMP - DependentActivation of Pro -MMP - 2 ” , The Journal of Neuroscience , vol. 25 , No . 27 , Jul . 6 , 2005 ; pp . 6401- 6408 ; Society Biological Chemistry , vol. 275 , No . 52 , Dec. 29 , 2000 ; pp . 41415 for Neuroscience . 41423 ; The American Society for Biochemistry and Molecular Gutierrez -Fernandez et al. , “ Increased Inflammation Delays Wound Biology , Inc . Healing in Mice Deficient in Collagenase - 2 (MMP - 8 ) " , The FASEB U . S . Patent and Trademark Office as International Searching Journal , vol. 21 , No . 10 , Aug . 2007 , pp . 2580 - 2591 . Authority, “ International Search Report and Written Opinion for Hadass et al. , " Selective Inhibition of Matrix Metalloproteinase - 9 patent application No. PCT /US2015 /016950 , ” dated May 20 , 2015 ; Attenuates Secondary Damage Resulting from Severe Traumatic Brain Injury ” , PLoS One , vol . 8 , No. 10 , e76904 ; Oct . 23 , 2013 , pp . 9 pgs. , published by International Bureau of WIPO (World Intel 1 - 14 ; Open Access. lectual Property Organization ). Harsha et al. , “ ADAM12 : a Potential Target for the Treatment of Zhang et al. , “ Role of Matrix Metalloproteinases and Therapeutic Chronic Wounds” , Journal of Molecular Medicine ( Berlin ), vol. 86 , Benefits of Their Inhibition in Spinal Cord Injury ” , No. 8 , Aug . 2008 , pp . 961 - 969, National Institutes of Health Public Neurotherapeutics: The Journal of American Society for Experi Access , 14 pgs . mental NeuroTherapeutics, Apr. 1 , 2011 ; 15 pgs .; Springerlink . com . Hesek et al ., “ Design and Characterization of a Metalloproteinase Zhou et al . , “ QM /MM Studies of the Matrix Metalloproteinase 2 Inhibitor - Tethered Resin for the Detection of Active MMPs in (MMP2 ) Inhibition Mechanism of ( S ) - SB -3CT and Its Oxirane Biological Samples” , Chemistry & Biology, vol. 13 , Apr. 21 , 2006 ; Analogue ” , Journal of Chemical Theory and Computation , vol. 6 , pp . 379 - 386 ; Elsevier Ltd . No . 11 , Jul. 10 , 2010 ; pp . 3580 - 3587 ; American Chemical Society . Hesek et al ., “ Synthesis of an Inhibitor - Tethered Resin for Detection Extended Search Report of the European Patent Office dated Jun . of Active Matrix Metalloproteinases Involved in Disease” , Journal 13, 2017 in EP Application No . 15752642 . 7 ; 7pgs. of Organic Chemistry , vol. 71, No . 16 , Jul. 11, 2006 ; pp . 5848 -5854 ; American Chemical Society . * cited by examiner U . S . Patent Apr. 24 , 2018 Sheet 1 of 9 US 9 , 951, 035 B2 Figure 1 U . S . Patent Apr. 24 , 2018 Sheet 2 of 9 US 9 ,951 , 035 B2 Opt Lowongamantanamankunnemwambambwa wwwwwwwwwwwwwwww 08 wwww Vrecorrere OCk ** . ** hammanamnanamantanamanmannanamanthammadowntimamiwaminanntmanninuman VN
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