2nd N€uromed Meeting 10-12 June, 2010 Faculty of Science, Sidi Mohamed Ben Abdellah University Fez -

N€uromed is a project funded by the European FP7. It is a capacities’ programme within the International Cooperation scheme, whose objective is to build capacities for Mediterranean Neuroscience Research, through twinning between EU research centers (in , Italy and Spain) and emerging labs in the Mediterranean Partner Countries (, Egypt, Morocco and Turkey). Six months after the start of the project, most activities are now under way: exchanges have started, local events have taken place, lectures are planned, and recruitment is well advanced. However, most members do not know each other yet, and many of them do not really understand what N€uromed is about. Thus, beyond the scientific aspects of this meeting, which of course are central to the project, it must allow us to exchange views, understand the objectives, learn more about the other members’ work. This is way the meeting includes: - A high quality scientific workshop: the aim is to identify scientific strengths of the project on which we will build the future. Abstracts are published (http://.....), and a summary of each session will be available. - A Board meeting: which is the general assembly of the consortium where the methodology and work programme of N€uromed will be discussed. - A Strategic Management Committee (SMC) meeting, where representatives of the 7 countries meet to discuss operational aspects. Welcome to this important event, N€uromed counts on you to do everything possible to make it successful! Thank you.

D. Boussaoud

Coordinator : [email protected]‐mrs.fr, Project Manager : [email protected]‐mrs.fr Web site: www.neuromedproject.eu Programme of the workshop

Thursday, 10 June Venue: Palais des Congrès

9:00 OFFICIAL OPENING OF THE WORKSHOP

10:00 Workshop “Getting funding from FP7”: Céline Damon (Marseille) & Sanaa Zebbakh (Rabat), Joumana Sweiss (Marseille), Benmoussa Hayat (Fès).

11:00 Strategic Management Committee (SMC) meeting

Session 1: Brain diseases and their treatment – Chair: A. Benazzouz & E. Khedr

13:30 Keynote speaker. Neurotoxicity, a major health concern in Morocco. Nouria Lakhdar-Ghazal, Mohamed V University, Rabat, Morocco.

14:00 Parkinson's disease: From pathophysiology to new therapeutical appraoches. Abdelhamid Benazzouz, CNRS & University of Bordeaux, Bordeaux, France

14:15 Transcranial Magnetic Stimulation and Study of Human Cognition in Alzheimer patients. Eman Khedr, University of Assiut, Egypt

14:30 Schizophrenia and learning by observation. Mohamed Agoub, Université Hassan II, Casablanca, Morocco.

14:45 Insight in bipolar disorder. Marc Adida, Univmed, Marseille, France

15:00 Coffee break

15:30 Some aspects of transduction mechanisms of endocannabinoids transmission. Mohammed Errami, University Abdelmalek Essaadi, Tetouan, Morocco

15:45 Molecular Mechanisms of Neurological Alterations in Hepatic Encephalopathy. Marta Llansola. Centro de Investigacion Principe Felipe, Valencia, Spain.

16:00 Neurosteroids: emerging players in the pathophysiology of hepatic encephalopathy and other neurologic disorders. S. Ahboucha, Cadi Ayyad University, Marrakech, Morocco. 16:15 General discussion: where are the strengths for N€uromed?

17:00 Public lecture. Psychiatric diseases. Omar Battas, Univ. Hassan II, Casablanca, Morocco

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Friday, 11 June

Session 2: The plastic brain: implications for learning and education Chair: M. Errami & H. Gamrani

8h30 Keynote speaker. Neuroplasticity and learning. Driss Boussaoud, CNRS & Aix- Marseille University, Marseille, France

9:00 Subcortical cytoskeleton and neuroplasticity. Latifa Dorbani-Mamine, USTHB, , Algeria

9:15 Experimental hyperthyroidism disrupts hippocampal long-term potentiation but not paired pulse facilitation in adult rats. Seda Artis, Medical Faculty of Erciyes University, Kayseri, Turkey

9:30 Coffee break

10:00 Neurogenesis after complete spinal cord transection in Pleurodeles waltlii. Marie Moftah, Alexandria University, Alexandria, Egypt

10:15 Organization of corticospinal projections in control and knockout-AC1 adult mice. Mohamed Bennis, University Cadi Ayyad, Marrakech, Morocco

10:30 The musician brain as an excellent model of brain plasticity. Mireille Besson, CNRS & Aix-Marseille University, Marseille, France

10:45 Evaluation of perceptual and mnemonic deficits in children. Ahmed Ahami, University Ibn Tofail, Kenitra, Morocco.

11:00 General discussion: where are the strengths for N€uromed?

11:30 Keynote speaker. History of mediterranean Neuroscience: The path to N€uromed. Wail Benjelloun, Mohamed V University, Rabat, Morocco

12:00 Lunch

Session 3: Adaptation to environmental stress Chair: M. Najimi & R. Magoul

13:30 Keynote speaker. Corticosterone: a clock endocrine output involved in the circadian functioning of serotoninergic neurons. Paul Pévet, Strasbourg University, Strasbourg, France

14:00 Water deprivation affects the neural and glial system in a desert rodent the mérione Shawi. Halima Gamrani, Cadi Ayyad University, Marrakech, Morocco.

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14:15 EM66-containing neurons in the hypothalamic parvocellular paraventricular nucleus of the rat: plasticity related to stress. Rabia Magoul, Sidi Med Ben Abdallah University, Fes, Morocco

14:30 Differential effect of stress on neurogenesis in rat adult central nervous system. Mohamed Najimi, Moulay Slimane University, Béni-Mellal, Morocco

14:45 Arrhythmogenicity of Epinephrine-Induced Hyperadrenergic Activity: An Applied Perspective. Miran Khalil Rakha, Suez Canal University (SCU), Ismailia, Egypt

15:00 General discussion: where are the strengths for N€uromed?

15:30 POSTER SESSION & Coffee

Session 4: Technological development of new methodologies for neurosciences Chair: E.H Bouyakhf & S. Boujraf

17:30 EEG adaptive linear predictive modeling applied to the learning process. Fakhita Regragui, LIMIARF, Mohamed V University, Rabat, Morocco

17:45 Virtual Reality and Neuroscience. Beatriz Rey Solaz, LabHuman, Valencia, Spain

18:00 Image processing for the detection of functional areas affected by stroke in the brain MRI. Yazid Cherfa, Saad Dahlab University, Blida, Algeria

18:15 Diffusion fMRI and BOLD-fMRI: Towards Better Understanding of White and Grey Matters Function. Said Boujraf, University Sidi Med Ben Abdellah, Fès, Morocco.

18:30 General discussion: where are the strengths for N€uromed?

19:00 Closing words

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TITLES OF THE POSTERS

Neurodegenerative diseases – Chair: E. Khedr & N. Lakhdar-Ghazal

1. Transcranial magnetic stimulation and Obsessive convulsive Neurosis. M. Abdel Rahman, Assiut University, Eypt. 2. Iron Deficiency Anemia Correlates With Cognitive Performances of Schoolchildren in Morocco. Y. Aboussaleh, A.O.T Ahami, M. El Hioui, S. Rusinek, F. Bonthoux. University Ibn Tofail, Kenitra, Morocco. 3. Anticonvulsant effect of butanolic extract of Anacyclus pyrethrum roots in rat. M. Bel Fakir, Z. Sokar, M. Bennis and S. Ba M'hamed. Cadi Ayyad University, Marrakech, Morocco. 4. Psychomotor development of exposed mice offspring to fenugreek seeds. L. Khalki, Z. Sokar and S. Ba M'hamed. Cadi Ayyad University, Marrakech, Morocco. 5. Perna perna (Mollusca, Bivalvia): evaluation of pollution on the neuroseceretory cells of cerebroid ganglia and sexual cycle during an annual cycle. Klouche M.S., Idardare Z., Moukrim A., Lakhdar-Ghazal N., Benomar S. Mohamed V University, Rabat, Morocco. 6. Impact of pollution in neurosecretory cells of ganglia nerves of Molluscan Mytilidae : Approach of the neuroendocrine control. Benomar S., Aarab L., Klouche M.S., Moukrim A., Yacoubi B. and Mathieu M. Mohamed V University, Rabat, Morocco. 7. Chronic hyperammonemia induces tonic activation of NMDA receptors in cerebellum leading to a decrease of neuronal nitric oxide synthase activity. Nisrin El Mlili, Carmina Montoliu, Hanan Ahabrach, Omar Cauli, Amparo Urios, Errami Mohammed and Vicente Felipo. Centro de Investigacion Principe Felipe, Valencia, Spain. 8. Persistent effect of aluminum chronic toxicity on memory in adult wistar male rat. Azzaoui F-Z and Ahami A.O.T. Unit of Clinic and Cognitive Neuroscience and Health, Laboratory of Biology and Health, Department of Biology, Faculty of Science, Ibn Tofail University, Kenitra, Morocco. 9. Calcitonin-induced sleep disturbance in rat when injected in the lateral ventricle and into the periaqueductal gray. R. Aboufatima, A. Zyad, J. Hafid, A.Chait. Faculté des Sciences Semlalia, Cadi Ayyad University, Marrakech, Morocco.

10. Clinical and genetic aspects of spastic paraplegia. Ali Benomar, Mohamed V University, Rabat, Morocco.

Neuroplasticity – Chair: M. Moftah & D. Boussaoud 11. Neural correlates of observational learning in non human primates. Belmalih A., Thura D., Isbaine F., Brovelli A., Demolliens M., Meunier M. and Boussaoud D. INCM- CNRS & Aix-Marseille University, Marseille (France)

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12. Lack of melanopsin in ganglion cells and its impact on retinal clock. Lahouaoui H., Dkhissi-Benyahya O. and Bennis M. Cadi Ayyad University, Marrakech, Morocco ; Department of Chronobiology, INSERM U846, Bron, France. 13. Organization and functioning of the circadian clock of a diurnal rodent, Lemniscomys barbarous. Ouarour A., Faculty of Science, Abdelmalek Essaadi University, Tetouan, Morocco. Adaptation to environmental stress – Chair: P. Pévet & M. Llansola 14. Nervous adaptive mechanisms of the vertebrates in dry land: A cyto and morphofunctional approach. Z. Barka, A. Dekar and S. Ouali, USTHB, Algeria 15. Anorexigenic and orexigenic factors regulation in the rat dorsal vagal complex during stress-induced anorexia. F. Chigr, M. Najimi, F. Rachidi, C. Tardivel, J. Trouslard, E. Moyse. Sultan Moulay Slimane University, Béni-Mellal, Morocco ; CRN2M, Labo PNV, Aix Marseille Univeristy, Marseille, France. 16. Kisspeptin in the hypothalamus of the jerboa: sexual dimorphism and seasonal variation. S. El Ouezzani, Sidi Mohamed Ben Abdellah, Fes, Morocco. Technological developments – Chair: S. Boujraf & E.H Bouyakhf 17. Comparative Study between Bias Correction Algorithms in Magnetic Resonance Imaging. A. Cherfa and Y. Cherfa. Laboratory of research in medical imagery, University Saad Dahlab of Blida, Algeria. 18. 3D MR Brain Images segmentation using fuzzy methods: FCM and BCFCM. A. Cherfa and Y. Cherfa. Laboratory of research in medical imagery, University Saad Dahlab of Blida, Algeria. 19. Brain MRI segmentation by snakes. Image processing for the detection of functional areas affected by stroke in the brain MRI. Y. Yazid and A. Cherfa. Laboratory of research in medical imagery, University Saad Dahlab of Blida, Algeria.

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Agenda of the SMC Meeting (Saturday, 12 June)

8:30 How are we doing 6 months after the kick off? (D. Boussaoud, Univmed) 9:00 WP1: Management and coordination (J. Sweiss, UnivMed) 9:15 WP2: Recruitment (M. Besson, UnivMed)

9:30 WP3: Training and exchange of staff (M. Alcañiz, UPVLC)

9:45 Coffee break

10:15 WP4: Workshops, lectures and schools (M. Errami, UAE)

10:30 WP5: Physical infrastructure (I. Kurnaz, YU)

10:40 WP6: Dissemination (R. Walker, XiWrite)

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