Accelerating Excellence The Official Publication of Bioscience in Ohio 2009

A Balanced Equation Bio execs discover great chemistry in Ohio

also inside: Ohio goes to market | $148 billion bioscience impact | Regional highlights s!% !%s s!% Published for: BioOhio (An Ohio Edison Center) 1275 Kinnear Road Accelerating 2009 Columbus, OH 43212 (614) 675-3686 | Fax: (614) 675-3687 [email protected] | www.bioohio.com BioOhio President & CEO Excellence Anthony Dennis, Ph.D. The Official Publication of Bioscience in Ohio Vice President John F. Lewis, Jr. Sr. Director, Workforce & Education William C. Tacon, Ph.D. -%33!'%3 Director, Corporate Communications 7 Message from BioOhio President & CEO Matt Schutte Anthony Dennis Director, Business Development Scott Osborne History provides lessons on the stimulating value of a crisis to Executive Assistant encourage innovation. Martie Hexamer 11 Message from the Governor of the State of Ohio Membership & Events Coordinator Ted Strickland Jennifer Goldsberry From Thomas Edison and the electric light to the Wright Brothers and Vice President, Finance & Administration aviation, Ohio has been at the center of ingenuity and innovation. William Poore Chief Operating Officer Robert A. Baxter &%!452%3 12 Balancing Act About BioOhio Bioscience executives in Ohio find a unique balance that enables BioOhio is robust success in both business achievement and personal satisfaction. Ohio’s bioscience membership and 18 Ohio bioscience and healthcare industry impact: development $148 billion organization. A 501(c)(3) organization, Summary of latest report on bioscience in Ohio reveals dramatic BioOhio is committed to attracting and growth and results. advancing bioscience organizations in Ohio through education, promotion, advocacy, 20 Ohio: This state goes to market engagement, and collaboration. Support for The world discovers that “Bio in Ohio” is money in the bank. BioOhio is provided by the State of Ohio as 24 well as BioOhio member organizations and BioOhio’s “Elite Eight” sponsors. Influence and impact of founding members endures, grows. 30 One State, Five Unique Bioregions Published by: BioMedia, LLC. A “road trip” around Ohio updates on bioscience growth in Return Undeliverable Addresses to: 311 Lloyd Road / Cleveland, OH 44132 Ohio’s five regions. (216)373 -7676 | Fax (206)339-4452 38 [email protected] Many Vantage Points, A Common Belief www.ohiobiomagazine.com BioOhio and Third Frontier Chairman Mark Collar shares the special Editor-in-Chief: Matt Schutte role of government and public/private partnerships in Ohio. Managing Editor: James O’Hare Circulation & Research: Joyce McMahon )."2)%&

© 2009 BioMedia, LLC Custom Publishing. All rights reserved. 36 Contents may not be reproduced by any means, in whole or in part, Bioscience News from Around Ohio without the prior written permission of the publisher and BioOhio Brief overviews of recent developments in Ohio.

From the Cover: Finding a striking balance in Ohio are executives Barbara Kunz, President of Health & Life Sciences Global Business, Battelle; David Scholl, CEO & President, Diagnostic Hybrids; Baiju Shah, CEO & President, BioEnterprise; and Mark Laskovics, President & COO of Girindus America.

The Official Publication of Bioscience in Ohio !%s s!% Message from the BioOhio Board of Trustees President & CEO Chairman Mark A. Collar of BioOhio Partner, Triathlon Medical Ventures Chairman, Third Frontier Advisory Board Anthony Dennis, Ph.D. Vice Chair Peter G. Kleinhenz Managing Director, CID Capital Past Chairman Tim Biro Managing Partner, Ohio Innovation Fund I

When do you innovate the best? Members John A. Bantle, II, Ph.D. Vice President, Research & Graduate Studies, In my personal history I find I have learned great step forward. For example, we are Wright State University and innovated more during times of great planning events around the state with other Greg Blackmore stress or failure than I have during periods organizations to help auto suppliers diversify Sr. Vice President and Group President, of success. Even into the medical Life Sciences, STERIS more importantly, industry value Rathindra Bose, Ph.D. I discovered that chain. Also, we have V.P. for Research and Creative Activity, The federal and state Ohio University I have always stimulus presents Ohio proposed to the come out of those federal government Sandra J. Degen, Ph.D. with an unprecedented Vice President for Research, University of Cincinnati periods better the need for a opportunity to not only Anthony J. Dennis, Ph.D. positioned than comprehensive President & CEO, BioOhio when I went in. maintain the industry, but bioscience Paul DiCorleto But this isn’t about make a great step forward. workforce strategy Chairman, Lerner Research Institute me—it’s about to complement the (Cleveland Clinic) and Chairman, Dept. of Molecular our state. Similarly, existing workforce Medicine, Case School of Medicine I believe that Ohio has a bright future and programs in order to fuel growth for existing Kevin Driscoll, Ph.D. that the biosciences will be one of the key and relocating companies. Furthermore, we Executive Director, Global Health Care Connect & Develop, Procter & Gamble Health Care industries to lead us through the current crisis are researching the creation of a virtual center John (Jack) Fisher and into that future. for biomedical device development to serve all Executive Vice President, Even during the current downturn, the of Ohio’s innovators. Ohio Farm Bureau Federation biosciences in Ohio—both industry and Ohio has tremendous bioscience assets in Mike Hooven academia—have continued to grow and add all corners of the state and I can think of no President & CEO, Enable Medical Technologies jobs. This growth is due to several factors: better time than right now to work together Barbara Kunz President, Health & Life Sciences Global Division, to harness the strength of those assets to s ANIDEALMIXOFCOMPANIESINCLUDING Battelle insure that Ohio brings about a brighter some of the world’s best CROs and Thomas J. Murphy pharmaceutical manufacturers future for everyone who benefits from more President & COO, Ben Venue Laboratories effective, efficient, and innovative bioscience s INCREASINGLYCOMPETITIVERESEARCH John M. Rice, Ph.D. developments. Managing Partner, Triathlon Medical Ventures excellence at Ohio’s universities As always, if you are a bioscience company David R. Scholl, Ph.D. s THESTEADYHANDOFSTATEANDREGIONAL operating in Ohio, we are proud to have you President & CEO, Diagnostic Hybrids, Inc. leadership supporting all phases of here. If you are a company who needs to grow Arnold W. Strauss, M.D. company formation and growth. or needs a new and supportive home, please Director, Cincinnati Children’s Research Foundation Chief Medical Officer, Cincinnati Children’s Hospital In fact, the federal and state stimulus presents give us a call and we can help you meet your Medical Center Ohio with an unprecedented opportunity to most optimistic goals. AE Caroline Whitacre, Ph.D. not only maintain the industry, but make a Vice President for Research, The Ohio State University

Accelerating Excellence !%s Looking for Deal Flow... Follow The Money These companies are putting Ohio on the national venture investment map.

Companies receiving private investment since 2004

AcelleRx Therapeutics Fused Multimodality Imaging SpineMatrix Akebia Therapeutics Future Path Medical StaffKnex Allostatix Ganeden Biotech STI American Safety & Health Great Lakes Pharmaceuticals Symphony Medical Institute Health Pro Brands Synapse Biomedical AMT Systems Hill Top Research Syncro Medical Innovations VasoLux MicroSystems LLC AnalizaDx HTP, Inc. Synostics Ventaira Pharmaceuticals Aria Analytics Icon Interventional Telerad Express Vertebration Aris Teleradiology Imalux ThermedX ViewRay Arteriocyte InfraRed Imaging Systems Tolera Vision Optimization AssureRx IntElect Medical Transcutaneous Technologies Vitality Distributing Athersys Interscopic Analysis Treatment-on-Line WholeHealth Atricure Interventional Imaging, Inc. Trek Diagnostics WIL Research Laboratories Avantec InVasc Therapeutics Turning Point, LLC within3 Axiom Laboratory Partners Tursiop Technologies Workflow.com AxioMed Spine Life Line Screening Vascular Biogenics Xanthostat Ayalogic M2M Imaging Biosys Medical MDG Medical Athersys (reverse Merger) Blue Chip Surgical Center MemberHealth Partners AtriCure Merlot OrthopediX Brainwashed Bargmann Management Minimally Invasive Devices Branam Oral Health Mork Process BioCrystal (product line purchased by Technologies Thermo Fisher Scientific) Myriad Health Calfacior BioCrystal (product line purchased by Invitrogen) Cardiac Power NanoStatics, LLC Biomec CardioInsight Technologies NCRx Optical Cleveland BioLabs Cell Targeting NDI Medical Cervilenz Neoprobe EdgePark Surgical ChanTest Neuros Medical Eurand CH Mack NextMed Systems Healthcare Transaction Processors (purchased by Clear Catheter NineSigma McKesson) Cleveland BioLabs Noteworthy Medical Hygenic Clevex Ogenix Memberhealth Opticon Medical Click4Care NDI Medical (product line alliance with partial exit) Copernicus Therapeutics Orthohelix RSB Spine Critisense P2D Inc Sears Dental and Dental Care CryMed PartsSource CSF Therapeutics Percuvision Shared P.E.T. Imaging, LLC (purchased by Alliance Imaging) Danfoss AquaZ PeriTec Biosciences SourceOne Healthcare (purchased by Merry) Diagnostic Hybrids PetsDx Imaging DiraMed Phycotransgenics Theken Spine (purchased by Integra Life Sciences) WORTH $2.2 BILLION Early Sense PrevaHealth Trek Diagnostics (purchased by Magellen Biosciences) Endotronix PrognostiX Eris Medical Technologies Rescentris, Inc. USB / Anatrace (purchased by Affymetrix) Eurand Ricerca Biosciences LLC Wellcorp (purchased by Nationwide) Roscoe Medical BIOSCIENCE EXITS 2005-2009 Excera OHIO IPOs & ACQUISITIONS Whole Health Management (purchased by Franklin & Seidelmann Simbionix Walgreens) Freedom Meditech Spineform

Just follow the money to Ohio

www.BioOhio.coms!% Looking for Deals? $985 Million Health Care Over 130 investment groups found Private Equity Investment Since great opportunities in Ohio. 2004

Credit Suisse First Boston Lennon Trust, The Radius Ventures Crystal Ventures Life Science Capital Regional Commercialization Cystic Fibrosis Foundation Lorain County Community Fund Custer Capital College Foundation Reservoir Ventures Accel Partners Danish Strategic Partners LSKW Investments River Associates Accipiter Capital Management Deutsche Bank Securities Luxemburg Capital River Cities Capital Funds Aisling Capital Development Capital Ventures MB Venture Partners Riverside Capital Akron ArchAngels Network Docor MedEquity Partners RMS Investments Akron Radiology Group Domain Partners Miami Valley Ventures RMS Management Ampersand Ventures Draper Triangle Ventures Michael J. Fox Foundation Rocket Ventures Amphion Innovations DSM Venturing Morgenthaler Ventures Roulston Ventures Angiotech DW Healthcare Partners MPM BioEquities RSL Investments Astro Modeling Early Stage Partners Mutual Capital Safeguard Scientific Athenian Ventures Entrepreneurs Fund NCIC Capital Scius (Spire Capital) Battelle Ventures ExOxEmis NCT Ventures SG Capital Partners Beecken Petty O’Keefe Fidelity Biosciences New England Partners Southern Ohio Creates Capital Behrman Capital First Fifty Fund North Coast Angels Southwest Michigan First Life Science BIOMEC Fletcher Spaght Ventures Norwich Ventures Sterling Capital Biotechnology Value Fund Fort Washington Capital Nu Vista Partners Sun Bridge Partners Blue Chip Venture Company Partners Oak Investment Partners Summit Health Ventures Blue Point Capital Foundation Medical Partners Oakwood Medical Investors Summit Partners Boston Scientific Frantz Medical Ventures Ohio Tech Angel Fund Sunrise Equity Partners Bridge Fund Fusion Capital Fund OrbiMed Advisors Sycamore Partners Bridge Investment Fund Glengary Ventures Oxford Bioscience Talisman Capital Camden Partners GLIDE Fund PA Early Stage Partners TechColumbus Capital Resource Partners Greatbatch Palo Alto Investors TechGenesis Fund Case Technology Ventures Greylock Pappas Ventures Teton Capital Charter Life Sciences Hambrecht + Quist Partisan Management Health Foundation Paul Capital Thomas, McNerney & Chrysalis Ventures Partners CID Equity Partners Innovation Alliance Fund Platinum Montaur Life Sciences LLC Thomas Weisel Healthcare Cincinnati Children’s Innovation Ohio Fund Venture Partner Plymouth Venture Partners Tomorrow Fund Invesco Funds Toucan Ventures Polaris Venture Partners CincyTech Ventures Investor Growth Capital TL Ventures Pontifax Claritas Capital Isabella Capital Triathlon Medical Ventures Primus Venture Partners Cleveland Clinic Innovations James Richarson & Sons U.S. Venture Partners Proseed Cogene Ventures JumpStart Venture Investors LLC Psilos Group CompuGroup Kadima Partners Vivo Ventures QCA First Fund Core Network Kearny Venture Welsh Carson Queen City Angels Cowan Healthcare Kirtland Capital Xgen RA Capital Management

www.bioenterprise.com www.biostart.org www.ohio.edu/biotech/ www.techcolumbus.org!%s s!% Message from the Governor of the State of Ohio Ohio: Ted Strickland the Home to Innovation

Ohio has a long history of innovation that includes the remarkable and Clinic, the Ohio State University Medical School, and other Ohio fundamental contributions of pioneers such as Thomas Edison and the universities are just a few of our premier research institutions. To help Wright brothers. We have been the centerpiece of American ingenuity foster continued innovation in bioscience research, the Ohio Research for many generations. It is the intent of my administration to continue Scholars Program is attracting world-class scholars and researchers this legacy by investing in the intellectual, human and financial capital who will anchor our centers of excellence and build upon Ohio’s already that is needed to fuel an innovative economy. impressive research capabilities. The Ohio Research Scholars Program Ohio is already positioned to excel in the technologies that will propel provides grants to strengthen and increase the research led by Ohio’s the future economy. These technologies academic institutions in support of regional span advanced energy, advanced materials, economic priorities. Ohio is actively instruments-controls-electronics, power We are also celebrating learning by giving and propulsion, and biosciences. Our state investing in the intellectual, “ Ohio’s young talent the opportunity to learn is home to more than 1,100 companies human and financial capital from and grow with bioscience companies focused on bioscience—from innovative that will allow our state to through initiatives such as the Ohio Third start-ups to some of the world’s largest succeed in the future. Frontier Internship Program. The program corporations. Each company has a distinct has helped place more than 3,000 students advantage over their competition, because they operate in a state with outstanding academic research capabilities, in enriching educational” experiences with more than 700 companies a fully developed supply chain and public policy programs to help throughout Ohio. Innovation and economic prosperity flourish in centers ensure sufficient investment capital to support the continued growth of of science and research, and enhancing our young minds will help new biomedical technologies. strengthen Ohio’s reputation as a center of excellence. I’ve recently introduced an education reform and funding plan that places a priority Through the Ohio Third Frontier, we are building world-class research on fostering creativity and innovation in our schools and teaching programs, nurturing early-stage bioscience companies, and fostering students the problem-solving and critical thinking skills required in a technology development. Of the $893 million in Ohio Third Frontier funds st invested between January 2002 and December 2008, 37 percent directly 21 Century economy. supported bioscience-related research, as well as development and To thrive in today’s globally competitive world, standing still is not an commercialization initiatives. More resources have indirectly supported option. That is why Ohio is actively investing in the intellectual, human and investments made by pre-seed and venture capital funds into Ohio financial capital that will allow our state to succeed in the future. Whether biomedical companies, which has demonstrated our commitment to it’s supporting world-class research, assisting in a new start-up business maintaining and enhancing the strength of the bioscience industry in Ohio. or nurturing young minds, Ohio is committed to enhancing our state’s Companies across the State of Ohio benefit from a vast network of assets. Each investment we make today will ensure Ohio’s continued research organizations and bioscience leaders. Battelle, the Cleveland leadership as a home to innovation for many generations to come. AE

!%s Cover Story

Ohio has supported Diagnostic Hybrids in many ways since it was founded and attracted now- President & CEO David Scholl as Director of Research in 1983. Balancing Act Four bioscience executives share the secrets of creating and balancing both career success and personal satisfaction.

A not-so-hidden gem in the bioscience industry, Ohio Unlike other locations, Ohio offers access to a community eager boasts over 1,100 bioscience companies, more than 50,000 to embrace and help new businesses assimilate. Ohio’s culture is employees—not including healthcare workers—and $700 million in marked by collaboration, where even the most influential leaders annual research. in the bioscience industry are accessible. The business support infrastructure in Ohio helps companies succeed and grow and not Ohio is a hotbed of bioscience activity in the center of the Midwest. surprisingly, the talent pool of bioscience professionals in Ohio is vast. Beyond the number of companies and research institutions, however, With all these benefits, it’s no wonder Ohio ranks among the there’s something else happening here. top states for bioscience industry strength. Here’s what four top In Ohio, executives can successfully pursue their career as well as their executives in the bioscience community have to share about the personal aspirations, and entrepreneurs can build global businesses balanced equation between business opportunities and personal while still making it home in time for dinner with their families. lives they’ve found in Ohio. s!% David Scholl 0RESIDENT#%/ $IAGNOSTIC(YBRIDSs!THENS

For David Scholl, president and CEO of Diagnostic Hybrids, the state of Ohio has provided a wealth of opportunities for both his business and his family through every growth stage. Diagnostic Hybrids innovates, develops, manufactures and markets cellular and molecular diagnostic kits for various applications in detecting a wide range of diseases. Since its founding in 1983, the company has benefited from Ohio’s programs every step of the way. As a relatively young company, Diagnostic Hybrids tapped into a state loan in the belief that the product it was developing would have big implications in the industry. The company’s confidence paid off, and so did Ohio’s investment. That product now represents close to 70 percent of the market share in its category. work. Kunz is impressed by Ohio’s economic Several years later, Diagnostic Hybrids collaborated with Ohio University development efforts to bring more bioscience to secure state funding through Ohio’s Technology Action Fund to bring entities to the state. life. A more balanced a particular scientist and his technology to the university. This effort lifestyle in Ohio provides Kunz time to pursue personal interests like gardening. balance. ultimately generated nearly 40 jobs at Diagnostic Hybrids. “This was a great example of collaboration that was a winning project for us, and it’s returning mightily on the state’s $1 million investment,” Scholl says. Barbara Kunz President, Battelle’s Health & Life Sciences Recently Diagnostic Hybrids was awarded a grant through Ohio’s Third 'LOBAL"USINESSs#OLUMBUS Frontier Program to work with Case Western Reserve University on an initiative that they would not have otherwise been able to pursue. With renowned hospitals, research centers and manufacturing Diagnostic Hybrids is building a 4,000-square-foot facility in Cleveland facilities working together to develop new advances in bioscience, Ohio to support the collaboration. offers companies in this industry a true culture of collaboration. This Scholl credits Ohio’s tax reform with helping enable Diagnostic Hybrids’ community spirit extends beyond the business environment, however, to enrich personal lives as well. recent expansion by eliminating tax on machinery and equipment as well as sales outside Ohio. When Barbara Kunz, president of Battelle’s Health & Life Sciences Global Business, first relocated to Columbus to join Battelle in 2007, While his business has matured, so has Scholl’s family. His children she was immediately impressed by the synergy and alliances between are adults now, but through the years Ohio has afforded the Scholls the bioscience entities. ability to lead a rich, balanced lifestyle. “I have been astounded at the amount of opportunity that exists here in When his children were little, Scholl’s short commute allowed him to Ohio, in Columbus specifically, to work on bioscience related initiatives with take time out of the day to coach Little League and still return to the people who are doing world-class research and clinical practice,” Kunz says. office to finish his day. As one of Battelle’s four global businesses, the Health & Life Sciences Athens offers many outdoor activities but Scholl says the state’s options business focuses on delivering a comprehensive set of R&D services that solve complex challenges focused on the biotechnology, medical are endless. “With an hour and a half’s trip, we can be sitting at an Ohio device, and pharmaceutical markets and public health sectors. State football game or at a Cincinnati Reds baseball game. Those are the features that have made the ‘life’ side of it for me,” he says. As a result, it’s critical for the organization to engage with other entities to make advances in the field. Kunz believes one of Ohio’s biggest Scholl believes living in Ohio has enabled him to lead the lifestyle many strengths is the sense of community in this industry. “There’s an open executives crave. “I just wanted to be a successful entrepreneur, and so invitation to get involved, and I’ve been impressed by how easy it is to the combination of being able to do that within a relatively short period get very influential people around a table to focus on an issue that really of time and being able to do family things was a huge plus. I think most will improve lives,” she says. entrepreneurs will recognize what I mean by that,” he concluded. continued on following page !%s Ohio’s collaborative community also includes the economic develop- Kunz finds navigating her life in Ohio much easier than in other places ment sector, focused on bringing more bioscience businesses to she has lived. She enjoys her easy access to Ohio’s park system where the state. she walks, jogs or bikes. Kunz also takes advantage of Ohio’s many Kunz is excited about Ohio’s economic development activities, which museums and sporting events, and she finds that the time she spends involve the state, the universities and bioscience organizations. The gardening rejuvenates her mind. result has been a tremendous amount of growth in the industry. “The difference in accessing things that you need in your daily life is While numerous initiatives in the bioscience community keep Kunz tremendously different compared to my experiences living on the East busy, she has found a similar collaborative environment in her personal coast,” Kunz observes. endeavors. She is involved in non-profit organizations and leverages With easier access to both work and play, Kunz is happy to have found Ohio’s university system for personal enrichment and networking with a balance in her business and personal life in Ohio. like-minded Ohioans.

work. Shah believes the business support Baiju Shah Ohio provides the 0RESIDENT#%/ "IO%NTERPRISEs#LEVELAND bioscience industry is unmatched in other states. life. Shah and Ohio’s access to business opportunities and numerous ways his family enjoy The to lead a balanced lifestyle convince many bio executives to come to Cleveland Botanical Ohio—and stay here. Gardens and other easily accessible Ohio Baiju Shah is at the forefront of efforts to ensure fast-growth attractions. balance. biomedical companies benefit from all Ohio has to offer. He is the president and CEO of Cleveland-based BioEnterprise, a business formation, recruitment and acceleration initiative designed to grow healthcare companies and commercialize bioscience technologies. BioEnterprise’s primary focus is on connecting emerging companies in the Cleveland area with clinical institutions, commercial partners and venture capitalists. Shah praises Ohio’s business support initiatives, including the “phenomenal tax environment,” but says for the companies he assists, the most important business advantages to being in Ohio are access and support. Ohio’s infrastructure provides companies with connections to the resources they need to grow. Shah believes that the support Ohio provides to help launch businesses is distinctive. “It doesn’t exist in the same breadth in other locations,” he says. The influential community involved in recruiting businesses to Ohio is unmatched. “Companies considering Ohio as a location are floored by the type of meetings we arrange for them in their preliminary visits,” Shah says. Once these companies relocate to Ohio, organizations like BioEnterprise and BioOhio ensure the support continues. “We don’t just give them a list of resources. We go the extra step to introduce them to the right people.” It’s rewarding for Shah to see many entrepreneurs succeed in Ohio. He knows that the business and personal benefits of living in Ohio can’t be found elsewhere.

continued on following page s!% Although Shah grew up in Ohio, he has lived abroad and in locations Festival, Ingenuity Arts Festival and local farmers’ markets. What strikes across the East coast. He returned to Ohio, though, because he knew Shah is the easy access to almost anything his family wants to do. he could pursue his passions here. “The ability to be spontaneous is a definite benefit to families,” he says. Not only has he been able to grow BioEnterprise into a successful “We can decide what we want to do that day. In other places you need operation with more than $820 million in funding attracted by the longer lead times and have to plan way in advance. Here, it’s a very companies they have supported, but he leads an active and balanced different life and level of flexibility that’s enjoyable.” personal life as well. Shah is having great success leading BioEnterprise to achieve its goal The Shahs enjoy local amenities like the Cleveland Botanical Gardens, of helping people around the world live better lives, all the while living a NASA Glenn Center and Ohio’s many festivals like the Maple Syrup rewarding, balanced life of his own in Ohio.

Mark Laskovics 0RESIDENTAND#// 'IRINDUS!MERICA )NCs#INCINNATI

Ohio’s strong support of the bioscience industry, robust university system and the ability to lead a balanced life provides an ideal combination for bio companies and their employees to succeed. As a result, Ohio’s pool of talented workers in the bioscience industry is robust. This talent pool is one of biggest benefits to building a bio business in Ohio, according to Dr. Mark Laskovics, president and chief operating officer of Girindus America, Inc. Girindus is a technology-driven company offering the pharmaceutical and cosmetic industries comprehensive skills, including process R&D, cGMP-compliant scale-up and manufacture of active ingredients, as well as regulatory support. “We’re a technology-based company and hire a lot of chemists,” Laskovics says. “Ohio has an amazing university system so the labor work. A recent Ohio Third Frontier grant has pool is very rich in the technology area.” In addition to fueling a enabled Girindus to build a new production population of bioscience professionals, Ohio’s universities offer other facility for a unique class of compounds. life. In Ohio, Laskovics enjoys a variety of leisure activities opportunities for Girindus. including rebuilding a 1972 VW Beetle. balance. “The professors at the University of Cincinnati’s Chemistry Department have been especially helpful in putting us in touch with resources we need. We’ve found the interface between the university and our company is very important,” Laskovics adds. Ohio’s business-friendly environment also has been instrumental in the company’s continued growth. A recent $1.2 million Ohio Third Frontier grant enabled Girindus to build a production facility for a synthesis area for a unique class of compounds. “This allowed us to get into this business at the beginning, and it’s turned out to be a nice source of growing revenue in that area,” he says. Laskovics credits Hamilton County for helping the company in its early days by making the team aware of training grants and helping them put together a tax abatement package. “Any time I’ve needed anything, the state, the county and the city of Reading have been very helpful in moving us along,” he says.

continued on following page !%s Laskovics believes part of the reason Ohio’s talent pool is so rich is that people want to stay here. Ohio’s reasonable cost of living and easy lifestyle attract people and keep them. “The convenience of living in a state where major things like entertainment, professional sports, your work and your home are accessible and affordable makes it pretty easy to live a full life,” he says. This more relaxed environment allows Laskovics to enjoy a range of activities in his free time, from biking the trails in the Loveland area to rebuilding his wife’s beloved ’72 Volkswagen Beetle from scratch. After living all over the world, Laskovics and his family enjoy Ohio most for its extensive business opportunities and opportunity for a balanced lifestyle.

In every region of Ohio, executives express the same sentiment: Ohio is an ideal location to build and grow a bioscience business. With a state dedicated to supporting the industry, a collaborative professional community, a robust economic development effort and a vast pool of bioscience talent fed by Ohio’s outstanding university system, the success of the state’s bioscience industry is growing. Special appreciation to the Ohio Ohio delivers on its promise of a business-friendly environment combined with a relaxed, affordable Business Development Coalition, and accessible place to live. The state continues to emerge as a bioscience force. Those lucky Paul Werth Associates, and George C. Anderson Photography for their enough to call Ohio home are finding its work-life balance a winning equation. E A assistance on this feature.

s!% !%s Ohio bioscience & healthcare industry impact:

$148 billion

A report published by BioOhio in January entities were operating in the state. While Bioscience-related entities include those reveals the importance of bioscience and company launches and relocations explain involved in research, development, and health care to Ohio’s economic resurgence. some of the 39.5% increase since 2007 marketing of pharmaceuticals, diagnostics, bioinformatics, medical devices, medical The overall economic impact of Ohio-based (818), the expansion is mostly attributable to a more thorough census of organizations. equipment, biotechnology products, and bioscience is $148.2 billion, representing For instance, 636 Ohio companies are FDA- health-related products. 15.7% of Ohio’s total economic output. certified to manufacture medical devices Bioscience also directly and indirectly Half of Ohio’s bioscience entities (574) are and 88 facilities in the state are FDA- located in northeast Ohio, which includes generates 1.4 million jobs in Ohio. certified to manufacture pharmaceuticals. the Cleveland area, Akron, Canton, and BioOhio’s comprehensive definition of the BioOhio determined that nearly half of Youngstown. Southwest Ohio, anchored by bioscience industry includes three integrated these companies are actively involved in Cincinnati, and central Ohio, which includes sectors: commercial bioscience entities, the value chain of at least one commercial the capital Columbus, are each home to about hospitals and healthcare providers, and bioscience product. 200 of the state’s bioscience-related entities. medical colleges. The commercial bioscience sector alone accounts for a $33.8 billion overall economic impact and 50,100 direct jobs, up from $27.3 billion and 48,485 direct jobs in 2006. When indirect and induced jobs are factored, the commercial bioscience employment impact jumps to 135,136. Analysis of commercial bioscience industry segments revealed research and development as the top employment sector (12,415), while agricultural biotechnology contributed the largest direct economic impact ($10.7 billion). Medical device and equipment manufacturers directly employ 9,757 Ohioans. Bioscience, medical technology, and research organizations continue to thrive in Ohio. As of December 2008, 1,141 bioscience-related

s!% or announced new facilities in Ohio; 36 projects occurred in 2007. Noteworthy 2007 examples include: Philips Medical expanding R&D space for their imaging systems in Highland Heights; growing CROs like Kendle International in Cincinnati, Charles River Labs in Spencerville, and WIL Research in Ashland; Ben Venue Labs’ new 244,000 square foot facility; and Cardinal Health breaking ground on a $50 million, 250,000 square foot facility at its Dublin headquarters. “The current global economic crisis is affecting every industry sector,” said BioOhio President & CEO Tony Dennis, “but a solid infrastructure and sustained growth will help Ohio’s bioscience industry weather the storm expansion continued to rise in Ohio. Overall, and position it for explosive growth when the nearly $2.5 billion were invested across Ohio economy recovers.” to accelerate bioscience growth in 2007, Commenting on the strength of agricultural almost doubling the 2006 total. The sources of biotechnology in the state, Ohio State’s Vice funding include venture capital, angel funds, President for Agricultural Administration Bobby IPOs, SBIR/STTR, state biomedical grants, Moser said, “Agbioscience is a key driver of acquisitions, and NSF and NIH grants. economic progress and technology-based The largest portion of the 2007 increase was economic development for the U.S. and “exit” related, as six acquisitions and two Ohio. Because of a strong R&D and outreach IPOs generated more than $1 billion, 44% of infrastructure together with the support of total investment in Ohio bioscience ventures. multiple stakeholders across the state, Ohio Universal American Financial Corp’s purchase has moved into an early leadership position in of MemberHealth for $630 million represented this area.” the largest investment in 2007. “The Ohio Bioscience Growth Report clearly The report also reveals that funding for For the complete report and appendix, visit shows that Ohio continues to make great research, company formation, and company www.bioohio.com. AE strides in the biosciences, and our bioscience industry is on the fast track creating jobs of the future for Ohioans,” said Lieutenant Governor Lee Fisher. “We are once again rated as one of the nation’s top technological innovators, recognition of the wide diversity of world-class research institutions, medical centers, and visionary companies that call Ohio home.” From 2004 to 2007, an average of 66 new companies began operation in Ohio each year. In 2007, Ohio welcomed 60 bioscience organizations by way of new company launches or companies establishing their first facility in the state, including AcelleRX Therapeutics (Cleveland), Akebia Therapeutics (Cincinnati), Freedom Meditech (Cleveland/Toledo), and Traycer Diagnostic Systems (Columbus). From 2005 through 2007, 100 bioscience- related companies either expanded operations !%s OHIO: This state goes to market

companies as well as those new to the state, increasing efficiency and decreasing costs. Contract research organizations, or CROs, offer their clients a wide range of services to aid in the pharma and medical device development process. And CROs are thriving in Ohio. Battelle in Columbus and Kendle in Cincinnati may be among the most recognized, but the pharmaceutical industry’s trend toward outsourcing also has been a boon to others— Charles River Laboratories’ in Spencerville, Medpace in Cincinnati, and WIL Research in Ashland, just to name a few. In Toledo, NAMSA is the global leader in guiding medical device manufacturers along the product testing and regulatory approval paths. Ohio CMOs (contract manufacturing organizations) are helping bioscience companies go to market too. Ohio’s rich manufacturing history and qualified workforce have helped give birth to hundreds of CMOs with experience ranging from therapeutics to devices. In Ohio, THE WORLD DISCOVERS THAT BIO IN OHIO IS LIKE MONEY IN THE BANK 636 companies } are FDA certified to manufacture Considering Ohio provided the formative globally, Ohio’s unique value proposition medical devices and 88 facilities are FDA thinking grounds of Thomas Edison and two has emerged: Ohio is where more and certified to produce pharmaceuticals. Wright brothers, the state boasts formidable more pharmaceutical, medical device, and In Strongsville, near Cleveland, Sparton roots in innovation and entrepreneurialism. diagnostics companies come to prototype, Medical Systems, Inc. is an FDA registered And with 5 Ohio institutions among the top test, manufacture, package, distribute, and and ISO 13485 contract design, development, 100 NIH funding recipients, research and market their products. Ohio goes to market. and manufacturing company specializing development activity employs thousands in Nearly 1,200 bioscience-related entities in complex laboratory instrumentation and Ohio and improves lives around the world. operate in Ohio, concentrated in market electromechanical point-of-care medical devices It’s true that innovation, entrepreneurs, sectors such as pharmaceuticals and for original equipment manufacturers (OEMs) and R&D help define a state or region as diagnostics, medical devices and equipment, and emerging companies. Medical product a bioscience “cluster,” but too often the agbio and imaging. This diverse industry manufacturers from around the world ask marketplace is forgotten in the definition. As presence has established robust supply chains Sparton Medical Systems for help when they’re the bioscience industry matures and evolves and industry assets for expanding in-state ready to go to market.

s!% development through to scale-up and full- scale commercialization.” BioOhio, the state’s bioscience membership and development organization, has embarked on a project with the Global Cardiovascular Innovation Center to catalog and link Ohio’s vast bioscience supply chain participants.

Sparton Medical “Once vetted, we expect to find the number Systems of supply chain resources in Ohio exceeding operations in the number of market-facing companies or Strongsville. ‘tier one’ companies,” commented BioOhio Business Development Director Scott Osborne, “both medical device and pharmaceutical.” Veridex, a Johnson & Johnson company, added features. With key U.S. operations in was one such company. Sparton Medical Vandalia, Ohio, Eurand has a strong track BioOhio and the GCIC are delineating Ohio’s produces the medical equipment driving record of developing products using its biomedical supply chain for two reasons: Veridex’s CellSearch System, which innovative drug formulation technologies. It 1) market-facing companies will find measures circulating tumor cells to predict progression-free survival and overall survival “We expect to find the number of supply chain in patients with metastatic breast, colorectal or prostate cancer. And the market is resources in Ohio exceeding the number of market- pleased. CellSearch was ranked as the top { facing companies or ‘tier one’ companies.” } medical innovation for 2009 at Cleveland Scott Osborne, BioOhio Clinic’s Medical Innovation Summit. has had four partnered products approved efficiencies and effectiveness through close “The value of contract development and by the FDA since 2001 and has a pipeline of proximity to their suppliers, and 2) suppliers manufacturing companies is their ability to product candidates in development for itself will discover the advantage of being close to repeatedly offer a well balanced approach and collaboration partners. to not only reduce timing and costs but also continued on following page “We manufacture all of the limit the risks involved with launching highly products that we develop regulated medical products,” said Kevin for ourselves and our Webb, business development manager at collaboration partners,” said Sparton Medical. Eurand Associate Director of On the pharma technology side, Eurand Marketing Erin O’Brien. “And partners with pharmaceutical and biotech our manufacturing processes companies, collaborating with them to bring and units are integrated with a product to market or extend the lifecycle our R&D facilities, which of a product in the market through value- enables taking products in

A capsule filling machine at Eurand’s U.S. manufacturing facility in Vandalia.

!%s key customers. Plans are already underway infrastructure to get their product wherever it market, literally. Cardinal Health is a $91 billion for a searchable web directory and an annual needs to go, allowing for just-in-time delivery global manufacturer and distributor of medical event to help suppliers and market-facing and lower shipping costs. and surgical supplies and technologies, companies connect. These advantages weren’t lost on MP securing the no. 19 spot in the Fortune 500. With a worldwide distribution network, “Beyond the web tools and an annual event,” Biomedicals, which manufactures and markets Cardinal’s healthcare supply chain divisions— Osborne added, “we want companies inside more than 55,000 products and is one of pharmaceutical and medical—generate $84 and outside Ohio to know that they can come the only companies in the industry to offer billion in revenue. to us with supply chain questions whenever a comprehensive line of life science, fine the need arises.” chemical and diagnostic products. Although And even the best medical products require branding expertise and marketing creativity to Biomedical companies not only enjoy its headquarters are in southern California, its ensure that once they get to market, they stay leveraging Ohio’s production assets and supply largest distribution center is in Solon, Ohio, a there. Ohio has that covered too. chain strengths, they realize the benefit of Cleveland suburb. being within 600 miles of 60% of the U.S. Dublin, Ohio-based Cardinal Health gets population and a world-class transportation billions of dollars of healthcare products to

Ohio is within 600 miles of 60 percent of the U.S. population. Headquartered in Columbus, GSW Worldwide is one of the largest healthcare advertising agencies in the world with offices in 13 major global markets. GSW is a key business unit of inVentiv Health, whose client roster is comprised of more than 350 leading pharma, bioscience, and healthcare payor companies, including the top 20 global pharmaceutical manufacturers. Other Ohio-based inVentiv Health divisions include Stonefly Communications, Blue Diesel, and the Navicor Group, with services ranging from product launch and branding to interactive marketing and strategic communications. Beyond inVentiv’s significant presence, several other Ohio firms specialize in bioscience and healthcare marketing communications, including OffWhite Salter in Marietta, Ohio. Advertising is on BioOhio’s mind as well. “We were blown away by the depth and breadth of Ohio’s biomedical supply chain,” admitted Osborne, “now it’s on us to make sure we’re not the only ones who know it.” AE

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!%s BioOhio’s Elite Eight Organization’s Founding Members influence and impact Ohio’s bioscience industry

For more than two decades, BioOhio has accelerated the growth of bioscience business, research, and workforce development in all corners of Ohio. But without the financial and inspirational support provided by its founding members, BioOhio certainly would have encountered more speed bumps along the way. But just because they support BioOhio isn’t why we’re giving them some ink. They are doing very cool things that are accelerating “Bio in Ohio” while making our world a better place to live. s!% University of Cincinnati income and 386 jobs to the region in 2007—its Faster diagnosis and more immediate test results are the desires biggest economic impact of many patients and physicians. University of Cincinnati engineer to date. Half of those Chong Ahn, Ph.D., has made it his mission to meet those needs. He’s start-ups stemmed from developing point-of-care clinical diagnostic technologies to quickly Ohio University research. analyze a person’s condition and status, focusing specifically on the Ohio University’s success quantitative analysis of cardiac biomarkers. at technology transfer Ahn’s “smart” polymer lab-on-a-chip diagnostic technology uses a has been recognized by small blood sample to provide detailed information on a patient’s the national media. Last condition within 5 to 10 minutes—leading to faster diagnosis and fall Forbes magazine treatment in the doctor’s office or the emergency department. The ranked Ohio University fourth in the country for development by this electrical and biomedical engineer has led to the John Kopchick the amount of license formation of a start-up company called Siloam Biosciences, Inc. Photo Credit: Rick Fatica revenue it generates Ahn, director of UC’s MicroSystem and BioMEMS Lab and founder in relation to its research funding based on 2006 data from the of Siloam, has already filed for 10 patents related to his technology Association of University Technology Managers (AUTM). The university and has received $2 million from federal funding sources and $5 had a 13 percent return on investment, according to the study. million from another investor. In November 2008 he opened an 8,000 square-foot manufacturing facility in Cincinnati’s Forest Park Procter & Gamble neighborhood, with hopes of launching his product in 2010. Scientific start-up companies often result in a number of highly skilled Health Care jobs. Siloam Biosciences is no exception. It will start with a staff of 15, Three billion times a day, P&G brands touch the lives of people with hope of growing to employ 50 people. around the world. P&G has the #1 or #2 product in over 20 different Ahn’s innovative and entrepreneurial spirit is mirrored across consumer categories and 99 percent of U.S. households purchased the University of Cincinnati by faculty experts in a wide range of a P&G product in 2008. Its $23 billion brands are leaders in their disciplines—from medicine to design to the life and social sciences. respective categories and platforms for innovation. And it’s that same entrepreneurial spirit that led to a 70 percent increase in industry support to the university in 2008. University of Cincinnati investigators are clearly thinking outside the box as they develop projects and seek funding sources. They are forming partnerships, licensing technologies, starting companies and creating jobs right here in Ohio—all to enhance the economy and speed the translation of research results. Ohio University In fiscal year 2008, Ohio University reported its highest royalty income to date—$5.9 million. Ohio University has been a top generator of licensing revenue among public colleges and universities in Ohio. Much of that income stems from a license for a 1988 research Strategic Focus. P&G’s Health Care businesses deliver more than discovery at the Edison Biotechnology Institute by Ohio Eminent $14 billion in annual global sales from a portfolio of trusted consumer Scholar John Kopchick. The work led to the development of a drug for and pharmaceutical brands. P&G Health Care has successfully people with acromegaly, a form of gigantism that creates excessive developed and marketed a wide range of products including: Actonel®, growth of bones and organs in adults. The drug, which achieved FDA Asacol®, Align®, Always®, Clearblue®, Crest®, Didronel®, Enablex®, approval in 2003, is now produced and marketed by Pfizer. Metamucil®, Oral B®, Pepto-Bismol®, Prilosec OTC®, Pur®, Tampax®, ® OU is reinvesting that revenue in new innovations in biotechnology, and Vicks . clean energy and transportation. Their patent filings more than P&G Health Care is focused on areas in which they have proven doubled from 15 in 2007 to 32 in 2008. Their small business expertise—respiratory health, digestive wellness, and water. It’s incubator, the Innovation Center, contributed $15 million in labor also selectively seeking innovation opportunities in areas of strategic !%s interest to other P&G businesses, like hair growth and skin aging. P&G You and P&G… think of the possibilities. concentrates on areas where consumers play a particularly active role To learn more, visit www.pgconnectdevelop.com or contact Rimma in managing their health and well-being. This strategic focus and a Driscoll at 513-622-3649 or [email protected]. targeted portfolio help ensure each development project and marketed product gets the attention it deserves. Case Western Reserve Track Record of Breakthrough Science & Collaborative Partnerships. More than 700 scientists and technical employees work University at 7 global technical centers with an unprecedented commitment to JumpStart Inc., the Northeast Ohio organization that accelerates the innovation in the broadest sense. Their collective scientific efforts have progress of early-stage businesses, and Case Technology Ventures resulted in more than 3,000 active health care patents. P&G Health (CTV), a pre-seed stage venture capital and technology validation Care also has a long-standing record of win-win partnerships, from fund at Case Western Reserve University, recently announced an small university-based labs to large multi-national companies. investment commitment of $375,000 in Neuros Medical, Inc., a Delighting the Consumer. In today’s evolving healthcare marketplace, Cleveland company commercializing neurostimulation technology efficacy, safety and compliance are no longer enough. It’s now a developed at the university. matter of truly delighting the better informed and more engaged Neuros’ technology was created by Drs. Kevin Kilgore and Niloy healthcare consumers. P&G’s 175-year heritage of deeply Bhadra of Case Western Reserve University’s Department of understanding the world’s consumers uniquely enables them to Biomedical Engineering and MetroHealth Medical Center, in transform innovative technologies into delightful product experiences. partnership with the Cleveland FES (Functional Electrical Stimulation) Center. It is referred to as “Nerve Block” and delivers high-frequency stimulation to sensory nerves in the peripheral nervous system to block chronic pain. The system consists of an electrode placed around a peripheral nerve and powered by a pace-maker size generator that is implanted into the chest cavity, abdomen, or lower leg. Because the generator operates in a much higher frequency range than conventional neurostimulation devices, Neuros’ technology is able to stop nerve activity to block pain completely, as opposed to simply masking the pain signal. The company’s initial target market is patients with chronic pain, specifically residual limb pain, a common occurrence after undergoing limb amputation due to vascular disease, circulatory issues, diabetes, cancer or trauma-related events. The company’s chief executive, Jon Snyder, is a CEO-in-residence at BioEnterprise and venture partner at Arboretum Ventures with over 20 years of experience in biomedical and healthcare sales, marketing, and operations. Case’s Vice President for Technology Management Dr. Joseph Jankowski commented, “It’s satisfying to see the intimate collaboration among JumpStart, BioEnterprise and Case Western Reserve University’s researchers and commercialization leadership so quickly lead to this venture that portends to impact the region in terms of health care and financial returns.” This is JumpStart’s 49th investment in its 38th company and its 4th direct co-investment with Case’s CTV Fund.

s!% genetic structures to foods that feed, power, and protect the health of the world. In fact, Ohio State’s extensive partnerships make the university second only to Duke University in industry-sponsored research. The many ongoing research efforts at Ohio State promise to advance innovation and fuel economic growth for Ohio and beyond. Cleveland Clinic Cleveland Clinic will begin an expansion of its reference laboratory, a project that will help improve medical laboratory testing capabilities for its patients and facilities throughout northeast Ohio. The project is The Ohio State University campus. expected to create 500 new jobs within the next five years. The construction of a new laboratory facility will allow for growth of Ohio State University the Pathology and Laboratory Medicine Institute at Cleveland Clinic, The Ohio State University stands ready to lead the new continued on following page “Innovation Revolution.” Teams of researchers throughout the university provide unique skills to an array of near- and long- term biological science needs. The OSU College of Food, Agricultural, and Environmental Sciences teams transform food, agricultural crops, and other organic matter into health-promoting products as well as alternative fuel sources. At the cellular level, the Medical Center and Health Science Colleges’ teams are unlocking humankind’s most fundamental codes and revolutionizing health care delivery. Ohio State physicians and researchers are at the forefront of personalized health care, using biomarkers, or genetics, to target treatment outcomes based upon an individual’s propensity to respond to selected protocols. The Center for Personalized Health Care at Ohio State’s Medical Center, founded in 2005, fosters incorporation of personalized health care initiatives into health maintenance and clinical care across the nation and the world. The Ohio State Comprehensive Cancer Center, one of 40 National Cancer Institute (NCI) designated centers, and the James Cancer Hospital and Solove Research Institute, rank among the top 20 cancer hospitals in the nation. The work of these entities has been enhanced with the award of an NCI Knowledge Center contract, making Ohio State part of NCI’s Cancer Biomedical Informatics Grid program. At Ohio State, NCI funding for research has more than quadrupled over the last 10 years and partnerships have been forged with companies such as Pfizer, Genentech, and Amgen. The foundational sciences are readily embraced by Ohio State and its public and private partners—from

!%s which tests tissues and other samples to help the medical community Battelle’s range detect, diagnose and treat diseases. of services is The 100,000-square-foot laboratory will be built on Cleveland Clinic’s performed in Good Main Campus. The Clinic is working with architects and engineers on Laboratory Practice the design for the building, which will include administrative space. (GLP) environments, which also foster the “This expansion will help enhance patient care by allowing us to development of in- provide more sophisticated testing with a faster turnaround time vitro technologies, in on results,” said Kandice Kottke-Marchant, M.D., Ph.D, chair of the silico modeling, and Pathology and Laboratory Medicine Institute. “It will also open up bioinformatics. new research and test development opportunities in molecular and DNA testing.” Public Health and Environmental Health Research and Evaluation. Battelle’s public health, environmental, and social The Institute has a staff of nearly 800, including 59 pathologists. scientists deliver quality solutions to the nation’s most challenging It annually generates nearly 10 million laboratory test results, health problems. Optimal study design and analysis methodology interpretations and diagnostic consultations. developed by Battelle and deployed using state-of-the-art software Medical testing is currently performed at Cleveland Clinic’s Laboratory technology are the core of its research services, providing clients with Medicine building. Once the new building opens, testing will be reliable information to support their decision-making. performed at both sites. Medical Device Solutions. Battelle’s disciplined approach to The Pathology and Laboratory Medicine Institute contains the systems engineering, programmatic risk management, material Department of Anatomic Pathology, the Department of Clinical science and detailed design reduces development risk and minimizes Pathology and the new Department of Molecular Pathology. It also cost and time to market. The engineering and life science expertise houses the academic Department of Pathology of the Cleveland Clinic enables clients to transform clinical needs into market-leading Lerner College of Medicine. medical devices in multiple therapeutic areas. To learn more about Battelle, please visit www.battelle.org. Battelle University Hospitals Battelle, the world’s largest non-profit, independent research and development organization, generates innovative products and University Hospitals Case Medical Center (UHCMC), in affiliation with solutions through its four global businesses: Health and Life Sciences, Case Western Reserve University (CWRU), operates one of the largest Energy Technology, National Security, and Laboratory Management. biomedical research centers in the United States. This longstanding By applying its full scope of science and technology (S&T) resources, affiliation was renewed in 2006 under a 50-year affiliation agreement Battelle delivers comprehensive research and development services, laboratory management and technology commercialization to support private industry and government agencies worldwide tasked with solving the most critical human health issues. Battelle’s solutions: improve the effectiveness of public health programs; enhance understanding of how the environment and other risk factors affect human health; and accelerate the development of safe and effective therapeutics, vaccines, diagnostics and medical devices. Battelle’s Health and Life Sciences Global Business continues to invest in laboratories, equipment, S&T, and scientific expertise to ensure the capacity and capability to deliver the comprehensive services required by clients in the following areas: Safety and Efficacy. Battelle’s commitment to regulatory compliance and ability to leverage unmatched scientific expertise, proprietary technology and world class facilities enables the advancement of therapeutics, diagnostics, vaccines, technology enhancement and crop science. Battelle also offers non-clinical services that encompass drug safety and efficacy, pharmacology, pathology, analytical and bioanalytical chemistry, and biomarker The Lerner Tower at University Hospitals discovery, development and validation. in Cleveland. s!% to leverage their individual and mutual strengths in research, education and clinical care. Recent developments include: Diaphragmatic Pacing System. UHCMC is the premier diaphragmatic pacing center in the world for quadriplegics and amyotrophic lateral sclerosis (ALS) sufferers. The pacing device used in this program was developed at CWRU and UHCMC in the 1990s and was approved for use in 2001. The late actor Christopher Reeve, who had suffered a spinal cord injury, became one of the first subjects to have the system implanted. The technology is being commercialized under a license agreement with Cleveland-based Synapse Biomedical. 3-D Map of the Heart. UHCMC is the site for an ongoing clinical study utilizing technology developed at UHCMC and CWRU to non- invasively image electrical activity on the surface of the heart. Patented algorithms are used to combine electrical data and chest CT scans, generating 3-D maps of the heart’s electrical activity. The system provides more information than electrocardiograms, is non-invasive and has wide application in the diagnosis of electrical abnormalities during various cardiac diseases. Cleveland’s CardioInsight Technologies is developing the technology. Reverse Cancer Cell Resistance to Chemotherapy. UHCMC is the only site in the U.S. to use reverse cancer cell resistance to chemotherapy. Supported by Tracon Pharmaceuticals, it is a “first in humans” clinical safety study involving a small molecule inhibitor (methoxyamine) aimed at base excision repair that is intended to reverse cancer cell resistance to chemotherapy. This research was conducted as part of the UHCMC Ireland Cancer Center Therapeutics Development Program. University Hospitals has been serving patients for more than 140 years. It has embarked on its Vision 2010 strategic plan which calls for more than $1 billion in investments for the system. The plan reaffirms a strong commitment to the University Hospitals Case Medical Center campus with new facilities and the expansion of services, along with new construction and enhancements to UH suburban ambulatory centers. AE

!%s Bioscience Roadtrip ne State 5 Robus

A”Road Trip” around Ohio reveals common purpose, unique assets

Unlike most states (and even many Proxy plans to invest $1.5 million in And while a popular trend for retirees countries), Ohio doesn’t rely on a single city capital and $1.8 million in annual payroll in from Ohio is to look southward, a growing or region to carry its bioscience flag. Just as Cleveland. Proxy Biomedical considered other bioscience company in Florida perhaps is the buckeye tree is known for its distinctive life science regions for this expansion, but signaling another trend as it instead looks compound leaf made of five leaflets, Ohio ultimately chose northeast Ohio. The main north for the next phase of its life. With boasts five regions with distinct, vibrant reasons: 1) the region’s leading healthcare assistance from Team NEO, BioEnterprise, bioscience business and research activity. and educational institutions—such as and the state of Ohio, ViewRay relocated Cleveland Clinic, University Hospitals, Case its headquarters from Gainesville to Let’s embark on a brief guided tour of the Western Reserve University, Cleveland Cleveland. The move was propelled after a accomplishments, partnerships, and unique State University and more than 40 others, group of key investors offered ViewRay a $25 assets found throughout the Buckeye state. 2) the state of Ohio’s strong commitment million investment to move from Gainesville to Northeast Ohio to the biomedical industry, and 3) the any leading center of bioscience innovation. services of supporting organizations such as Northeast Ohio clearly fit the bill. We start our tour in the active northeast BioEnterprise and TeamNEO. corner of the state. During the past year ViewRay is developing image-guided radiation alone, northeast Ohio attracted ten biomedical therapy technologies in a 41,000-square-foot companies from other states and foreign Cleveland facility and plans to create 100 jobs countries. A busy region, indeed. within three years. “Access to partners, customers and www.bioenterprise.com www.teamNEO.org In January, 2009, Proxy Biomedical of workforce is critical to our success,” says Ireland opened its US headquarters in Peter Gingras, Proxy Biomedical’s CEO. Northwest Ohio Cleveland. The Cleveland Proxy Biomedical “By establishing operations in northeast Leave Northeast Ohio and follow the Lake Erie facility designs, develops, manufactures Ohio, we take advantage of critical product shoreline about 100 miles to the west, past and markets biomaterials for the repair and development support and clinical trials that the Lake Erie islands, and you’ll find more regeneration of tissue for advanced surgical will enable our accelerated growth and evidence of bioscience growth. Northwest procedures. The company develops proprietary service to the world’s largest market, the Ohio’s Regional Growth Partnership (RGP), implantable meshes and engineered bio- United States.” Proxy has already developed through the Third Frontier’s ESP program materials for surgical applications, tissue strategic partnerships with Case Western regeneration and tissue repair. Proxy also Reserve University, Cleveland Clinic, the (Rocket Ventures) and northwest Ohio’s offers a disposable, easy-to-use suture Global Cardiovascular Innovation Center Edison Incubator (Launch), has developed a grasper needle for laparoscopic surgery. (GCIC) as well as a Dayton, Ohio firm. continued on page 32 s!% st Bioscience Regions

Proxy Biomedical Limited, a Galway, Ireland-based developer of next generation medical products that use proprietary biomaterials technology, has recently established U.S. headquarters in Cleveland.

Rocket Ventures serves the entrepreneurial community in the 18-county Northwest Ohio region with a new facility and a new “BioCommercialization” approach.

Located in the heart of Dublin, Ohio’s Innovation Park, the 40,000-square-foot Dublin Entrepreneurial Center is prime space for viable concepts to become tomorrow’s industry-leading businesses

From left: Aniruddha The 36,000 square-foot Innovation Puntambekar, Ph.D., a senior Center is the home of Ohio University’s scientist, and Chong Ahn, technology business incubator. The Ph.D., CEO of Siloam, a Innovation Center Program provides Cincinnati-based bioscience incubation services to biotechnology company. companies, IT companies, and Photo courtesy of BIOSTART. companies that provide services to these two industry sectors. !%s Comprehensive Commercialization Process or completed establishment of 15 companies (CCP). The RGP’s partnership with the in the bioscience sector. Nearing the end of University of Toledo supplies critical executive their development stage are a dozen new talent to the many novel technologies being technologies, including commercialization of developed at the region’s universities and biologics, pharmaceuticals, medical devices, hospitals. HIT and agbio. A unique feature of In addition to this program is the managed companies, flexibility offered to RGP is assisting much faster in southwest Ohio than in the U.S. inventors. Suppose several others in the the inventor needs bioscience sector as a whole. to continue to devote and building critical Besides homegrown companies, southwest time to research or infrastructure. Ohio also is successfully recruiting new clinical work, but also companies, such as San Diego-based Amylin BioOhio’s most recent Bioscience Growth wishes to form a start-up company. The RGP Pharmaceuticals. Site Selection magazine Report reported 75 Bioscience companies in ensures that critical support services are made recently highlighted Amylin and five other northwest Ohio. RGP expects that number to available to the startup company—including Southwest Ohio companies—Alkermes, grow by 15 to 25 percent by 2009. an interim management team. CCP is now Eurand, Cognis, Prasco Laboratories and available for use by all local bioscience www.rgp.org Patheon—in a group of the fastest growing institutions in northwest Ohio. in Ohio. Southwest Ohio The RGP believes that the key to the bio- The startup scene is lively as well. Venture Greater Cincinnati also stands poised for science sector’s success is the optimization capital firms have more than $1 billion of the entire industry’s needs, not just those strong growth in the life science industry. under management and include a focus of the individual institutions. The RGP works Spurring the activity are increased federal on bioscience companies. Supported by a to serve as the unbiased connection to all of research dollars, rising venture capital activity growing base of seed-stage capital, at least bioscience resources in northwest Ohio. To and a growing community of local six bioscience companies have launched in meet this goal, the RGP created an initiative bioscience companies. recent years. Here are two that are developing called BioCommercialization to focus Leading the way are two major research technology licensed from local institutions and on the needs of northwest Ohio’s growing institutions in southwest Ohio that are companies. bioscience industry. attracting significant funding. The University Akebia Therapeutics specializes in the This effort aggregates the highly specialized of Cincinnati and Cincinnati Children’s discovery and development of breakthrough intellectual, physical and financial resources Hospital Medical Center have combined total small molecules focused on anemia and required for new and established bioscience research expenditures of $353 million. peripheral artery disease. Novartis was among companies. RGP is assembling advisory In addition to leadership from education its investors in a recent Series A financing boards made up of local industry leaders to and healthcare institutions, a vibrant round of $15.1 million. Akebia in-licensed guide BioCommercialization activities. commercial business sector is playing its initial drug development programs The first year of operations for the RGP a key role. from Cincinnati-based Procter & Technology Programs was 2008, during Gamble. The region is home to more than which Rocket Ventures and Launch initiated And Siloam Bioscience was 220 businesses involved founded based on technology in the research, testing developed at the UC and production of College of Engineering. pharmaceutical, The company develops medical and agricultural affordable solutions for products. Among the point-of-care testing in successful headquarters emergencies using smart, companies are Ethicon disposable “lab-on-a-chips” Endo-Surgery, Meridian on low-cost plastic platforms. Bioscience, Kendle Siloam is anticipating market New incubator space in International, AtriCure and entry within three years and expects southwest Ohio. Medpace. Also, clinical research is growing to grow from eight to 20 jobs. s!% All of this activity—from research institutions Besides acres of woods, waterways and and big businesses to startups and a wildlife, Athens County boasts a vibrant healthy funding climate—has led economic arts scene as well as unique shopping development officials in southwest Ohio to opportunities—everything from funky uptown identify a bioscience “cluster” that is creating shops to the Farmers’ Market, which features fertile ground on which companies can launch, organic, locally grown vegetables. locate, expand and thrive. The community and university support www.cincytechusa.com that sustains Athens’ distinctive nature is what enables Diagnostic Hybrids to thrive, Southeast Ohio Scholl said. When Dave Scholl moved to Athens County in Just as Diagnostic Hybrids won national 1977 as a young graduate student, he couldn’t acclaim for its astonishing 663% growth rate have imagined getting a ringside seat to the from 2000 to 2003, Scholl predicts Athens birth of the biotech industry. And he likely County will follow in its footsteps. couldn’t have imagined he would soon preside “Athens County has an unbeatable work over the explosive growth of an Inc. 500 ethic. This was once all coal mining territory. company—without ever leaving the county. Let’s face it, if you’re willing to go two miles As a Ph.D. candidate in microbiology at Ohio down into the ground to work, you’ve got the University, Dave worked with chemist-turned- tenacity and commitment that will benefit any nuclear physics pioneer Wilfred Konneker employer,” Scholl said. and other OU professors on the team that To read more about Athens County’s innovative developed the first transgenic animal. The character, visit www.businessremixed.com. team’s recombination technique started a windfall of opportunities for Diagnostic Central Ohio Hybrids, Inc., now the world’s largest cell Finally, we circle in on the center of the culture provider, for which Dave is president state in the region dominated by the and CEO. state’s capital, Columbus, and its many surrounding communities that are bubbling with bioscience growth.

“Athens proved to be fertile ground for us,” Scholl said. As proof of Athens County’s business-friendly While Ohio’s largest company, atmosphere, the Athens County Economic Cardinal Health, opened its doors to a Development Council recently launched www. 250,000-square-foot expansion of its businessremixed.com, a web site featuring corporate headquarters in Dublin, Ohio, this biotech success stories like Scholl’s, and spring, another opening was taking place in highlighting the lifestyle, culture and benefits the Emerald City. The Dublin Entrepreneurial of living and working in southeastern Ohio. Center (DEC) invited guests to experience the synergy of a new facility designed to spur Geoff Greenfield, co-founder of Athens-based start-up businesses into becoming the next Third Sun Solar & Wind Power Ltd., now one industry-leading corporation. of the Midwest’s leading solar contractors, lists just a few of the reasons he loves living After all, it was in Dublin that Bob Walter in Athens County: “Music, culture, food, began his entrepreneurial venture that international students, like-minded people, would become the $91-billion healthcare ecological consciousness. Plus it’s a safe, products and services company known close-knit community,” he added. as Cardinal Health. continued on following page !%s The DEC was created to support those next-generation entrepreneurs by providing a physical space that also provides access to both entrepreneurial services and capital from a variety of resources, including TechColumbus. Dublin’s efforts are not going unnoticed. In March, BusinessWeek magazine named Dublin the best small city in Ohio for start-ups. The DEC is located in the core of Innovation Park, a 1,300-acre technology park currently under development. The Park is adjacent to U.S. 33 and state Route 161, where the City of Dublin is investing $52 million in interchange improvements. Innovation Park is anchored by the state- of-the-art Dublin Methodist Hospital, which opened its doors in 2008, and is considered a model hospital for its evidence-based- design healing environment and cutting-edge technology, including a virtually paperless facility. In turn, the hospital’s opening has spawned a flurry of ancillary medical services and offices in the community. The city is currently considering the development of a $180 million proton therapy cancer treatment facility in the park. The bioscience sector is a growth industry in Ohio and one that is supported by the state. Last year, more than $2.5 billion was invested to accelerate Ohio’s bioscience growth, nearly doubling the previous year’s total. Dublin has 57 biotech and pharmaceutical companies, while the Columbus MSA lists 519. In the medical services industry, Dublin is home to 234 companies and the Columbus MSA includes 3,806. In addition to Cardinal Health, Dublin-based bioscience businesses include: Activaero America Inc., Bound Tree Medical, Butler Animal Health Supply, Cardiox, Neoprobe Corp., Opticon Medical and Smiths Medical. Learn more about central Ohio at www.dublin.oh.us AE

s!% Bioscience News from around Ohio

Senator Sherrod Brown announces new bill Connecticut medical device component to create jobs through workforce training in maker relocates to Kettering emerging industries March 30 – A Connecticut-based plastics manufacturer April 1 – U.S. Sen. Sherrod Brown (D-OH) joined Ohio with concentration in medical devices and analytical Board of Regents Chancellor Eric Fingerhut, BioOhio systems is moving its manufacturing operations to President and CEO Tony Dennis, and Kettering, a Dayton suburb. Ohio university and college presidents ADISCO will occupy approximately 5,000 square feet of to announce new legislation that would manufacturing space within the National Composite Center invest in bioscience and other emerging 1&& DQRQSURÀWIRXQGHGLQWRSURPRWHGHYHORS industries in Ohio. and commercialize advanced composite technology. The Brown’s “Strengthening Employment WUDQVLWLRQEHJDQLQ$SULODQGFRPSDQ\RIÀFLDOVH[SHFW Clusters to Organize Regional Success” to complete the relocation in 12 to 18 months. ADISCO’s (SECTORS) Act, which he introduced existing manufacturing facility in Connecticut will remain Senator today with Sen. Olympia Snowe (R- operational throughout this transition period. Sherrod Brown ME), would support the development of The Ohio Tax Credit Authority approved a six-year, specialized workforce training programs $203,217 job-creation tax credit for ADISCO. The 45 at two-year colleges to meet regional percent job creation tax credit requires the company to workforce needs of emerging industries maintain operations at the project site for 12 years. The RU´VHFWRUVµ%URZQDQG6QRZHÀUVW Ohio Department of Development described it as a $255,000 introduced this legislation in 2008. SURMHFWWKDWZLOOFUHDWHMREVLQWKUHHWRÀYH\HDUV “Workforce development and job creation go hand-in-hand,” said Brown. “By providing tailored education Chancellor programs for regional industry needs, Eric Fingerhut we can create and retain jobs in Ohio. We need to ensure that Ohio workers are equipped with the skills for jobs of the 21st century.” “The proposed SECTORS Act provides a framework which supports the implementation of educational programs, work- force training and infrastructure for the statewide expansion of Ohio’s bioscience industry,” said BioOhio’s Tony Dennis, “not limiting investment to just one region.” Dennis added The new home of ADISCO in the National Composite Center in Kettering. that the legislation would leverage Ohio community colleges’ growing involvement in the bioscience industry. In a Dayton Daily News article, ADISCO President Fletcher Brown said the company will hire up to four people this year The SECTORS Act provides grants for sector partnerships and about 14 in 2010, in addition to a handful of employees among institutions of higher education, industry, organized relocating from Connecticut. Adisco will initially operate as labor, and workforce boards. These partnerships would a hosted business in the NCC, but will move out to larger FUHDWHFXVWRPL]HGVROXWLRQVIRUVSHFLÀFLQGXVWULHVDWWKH quarters as the business grows, Brown said. regional level. A sector approach can focus on the dual goals of promoting the long-term competitiveness of industries and “The precision-machined polymers market is growing advancing employment opportunities for workers. and has applications in all of the Dayton area’s strategic industries,” said Marty Hohenberger, vice president of business recruitment for the Dayton Development Coalition.

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!%s ChanTest acquires Applied Cell Sciences organizations. A ribbon-cutting ceremony highlighted the RSHQLQJRI4('·VH[SDQGHGIDFLOLWLHVLQ0D\ÀHOG9LOODJHD Feb. 26 - The leading experts in ion channels and GPCR suburb of Cleveland. (G-protein coupled receptors)—key to drug discovery, development, and safety—are now united. ChanTest, QED is in the process of adding manufacturing, logistics the leading provider of ion channel testing services and and testing space and looks to double its work force during validated cell lines, has acquired Rockville, Maryland-based the year. The expansion is a tangible demonstration of Applied Cell Sciences. ACS specializes in GPCR services, the growing presence of the medical imaging industry in cell lines, and reagents. Cleveland. It is estimated that nearly 50 imaging companies with about 3,000 employees—including market leaders Philips Medical Systems, Hitachi Medical Systems, General Electric and Toshiba Medical Systems—have a presence in Northeast Ohio.

Supercomputer expansion to benefit Ohio

The combined company will maintain both facilities in bioscience industry Rockville and Cleveland. ChanTest currently has 70 Feb. 25 - The Ohio Supercomputer Center launched a $4 employees, while ACS employs 5. Going forward, ACS PLOOLRQH[SDQVLRQRILWVÁDJVKLSVXSHUFRPSXWLQJV\VWHP products and services will be marketed under the a strategic addition that will more than double current ChanTest name. FRPSXWLQJSRZHUDQGPHPRU\VLJQLÀFDQWO\LQFUHDVLQJ “We are now uniquely positioned to serve the drug discovery the Center’s computational capacity dedicated to Ohio’s and safety needs of pharmaceutical and biotech customers bioscience and research efforts. with the most-comprehensive portfolio available of ion channel and GPCR services, reagents, and cell lines, covering nearly half of the known drugable genome,” said &KDQ7HVW3UHVLGHQWDQG&KLHI([HFXWLYH2IÀFHU$UWKXU0 “Buzz” Brown, M.D., Ph.D. &RPSDQ\RIÀFLDOVVDLGWKDWZRUNKDVDOUHDG\EHJXQRQ new cell lines that combine GPCRs and ion channels to offer a more-complete assessment of compound’s promise in discovery or preclinical safety testing.

QED expands operations in Northeast Ohio Jan. 23 - Quality Electrodynamics (QED) hosted over 200 international visitors from the bioscience industry as well The expansion will integrate a new generation of IBM as from several governmental, educational, and research hardware into OSC’s IBM Cluster 1350, which became operational in January 2008. Because of the pent-up demand by Ohio researchers for supercomputing access, the new system reached operational capacity in just three months. “This expansion can further propel Ohio to the forefront of biosciences research and job creation,” said Stanley Ahalt, executive director of OSC. “With critical supercomputing resources, Ohio researchers can increase the state’s share of national bioscience funding.” 26&RIÀFLDOVGHWHUPLQHGWKDWWKHELRVFLHQFHVZRXOGEHRQH of the most productive areas in which the Center could focus investments, collaborations, research and market solutions. OSC’s partnerships include work with Nationwide &KLOGUHQ·V5HVHDUFK,QVWLWXWHRQWKHLQQRYDWLYH9LUWXDO

s!% 0LFURVFRS\WR0LFURDUUD\FDQFHULGHQWLÀFDWLRQSURMHFW the Governor’s Cup to Ohio for the third consecutive year which has garnered national attention. OSC also designates our state as the preferred location for capital partners with the Ohio State University Medical LQYHVWPHQWZKHUHFRPSDQLHVÀQGDVWDWHRISHUIHFWEDODQFH Center’s Biomedical Informatics Department, between business pursuits and quality of life.” working on its caGrid infrastructure and related Governor Strickland attributes Ohio’s third consecutive software, which provides a national network that Governor’s Cup win to the state’s manufacturing strengths, may speed cancer research discoveries. logistics capabilities, skilled workforce, and our competitive Expected to be fully operational by summer, the total business environment. The City of Dayton played an expanded system will increase in computing capacity from outstanding role this year, ranking number one in the WHUDÁRSVWRWHUDÁRSVDQGPRUHWKDQGRXEOHDYDLODEOH category for mid-sized metropolitan areas with populations memory, from 8.4 terabytes to 24 terabytes. between 200,000 and one million. AE

Ohio Leads the Nation in New and Expanded Business Facility Investment 0DUFK*RYHUQRU7HG6WULFNODQG and Lt. Governor Lee Fisher joined members of Ohio’s business and economic development communities and Ohio General Assembly to announce that the State of Ohio was awarded Site Selection

magazine’s Governor’s Cup Award for leading the nation in new and expanded facilities in 2008. The March edition of the magazine highlighted the award and Ohio’s economic accomplishments, which include 12 cities around the state with top 10 rankings. This year marks the seventh time Ohio has been awarded WKH*RYHUQRU·V&XSUHFHLYLQJWKHDZDUGLQ DQG7KHRFFDVLRQPDUNVWKHWKLUGZLQLQD row for Ohio and the state’s fourth in six years. ´%XVLQHVVHVFRQWLQXHWRGLVFRYHUWKHEHQHÀWVRILQYHVWLQJ in Ohio,” said Mark Barbash, interim director of the Ohio Department of Development. “Site Selection’s award of !%s ManyVantageVantage VantageVantage Points, Points,Points, A Common Belief As I near completion of six years as chair of leveraged a remarkable $3.5 billion in outside money—an almost 9 the Third Frontier Advisory Board, I exercise to 1 ratio. The combined funding has brought together the public and my typing skills. My purpose? To capture and private sectors to build or expand important industries in Ohio: solar share thoughts on the role of government in energy innovations in Toledo; cardiovascular technology in Cleveland; technology-based economic development, and medical imaging in Columbus to name just a few. and the special approach we are taking Over 500 companies have been created, attracted, or capitalized, here in Ohio. representing over 7,700 jobs at an average salary of $67,000. And First, a bit of background for the as the major new job growth that follows these new companies and sake of “transparency.” For industries takes root, more expansion capital will be attracted. In that 32 years, I worked for Procter way, the stimulus keeps on working. & Gamble. I started by By Mark Collar carrying a bag on the Diverse groups of Americans will come together when Chairman, BioOhio & Chairman, streets of Chicago and opportunity exists, and fair, practical programs give enterprising Third Frontier Advisory Board completed my career people a chance to compete. I have been pleased to find strong at P&G as president of support for the Third Frontier from Democrats and Republicans, the Pharmaceutical and Personal Health division. P&G is a great conservatives and liberals, large companies and small companies, company and I was blessed to work within this meritocracy, where private and public sector employees, academia and business everything starts with delighting our consumers. leaders, legacy and emerging industries. Since then I’ve pursued multi-faceted roles with opportunities to America was built on the basis of innovation, and make no make a difference. In addition to my involvement in the $1.6 billion mistake: innovation is alive and well in America. Great ideas build Third Frontier Project, I chair BioOhio and the Health Alliance of economies—ideas that result in exciting products and services that Cincinnati (a large hospital group), I am a founding board member help people improve their lives. of BIOSTART, and I serve on the boards of First Financial Bank Great innovation does not require the government to play a great and an emerging medical device company, AtriCure. I also serve role, but in times of economic stress government must prime as a venture partner at Triathlon, the largest bio-focused VC firm the innovation pump to make a real difference. And in times of in the region. As a result of these diverse roles, I see economic economic prosperity, well-designed governmental programs work development from numerous nooks, crannies and vantage points. in partnership with industry to ensure a continuing flow of great And here’s what I believe: technology and new industries we can’t even imagine today.

America’s free markets will continue to drive economic America’s greatness has not been fatally deflated by the actions growth and prosperity. Certainly, there’s a critical need for wise of a relative few. We are a country with a grand majority of people governmental regulation to protect the public. But government also from all walks of life, all socio-economic backgrounds and positions, has an imperative to not inhibit smart, enterprising people from all trying to do the right things with their talents, all with a desire profiting and creating jobs for others. Regulation must also not to make a difference. This grand majority believe that America is a insulate poor performers from suffering some losses. That’s the way place of opportunity for those who work. markets work, after all. The sooner we start celebrating what made America great, Governmental stimulation works when it does just celebrating success, and nourishing the prevailing sense of wanting that—stimulates the free markets by creating opportunities for to succeed, the sooner we will leave this lethargy, and get back on entrepreneurs to increase rewards or decrease risks. The Ohio Third our track to greatness. Let’s focus on the American grand majority Frontier program has been our model for successful stimulus. Over and celebrate the greatness they bring. the past six years, about $400 million in state investment have God bless the American dream. AE

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