PRACTICAL INFORMATION

Tuesday, 20th May 2014: International Clinical Trials’ Day Wednesday, 21st May 2014: ECRAN Project Meeting

Neumünster Abbey, City, Grand-Duchy of Luxembourg

Registration To register for the International Clinical Trials’ Day and / or for the ECRAN Project meetings, please sign up online: ECRIN & ICTD Registration

Meeting venue Neumünster Abbey Address: 28,rue Münster L-2160 Luxembourg (G.-D. de Luxembourg) Phone: (+352) 26 20 52 1 Fax: (+352) 26 20 19 80 E-mail: [email protected] http://www.ccrn.lu/en/Culture

Welcome Desk Our team is pleased to welcome and inform you in the lobby of the conference room José Ensch during all the meetings. Just follow the signs WELCOME DESK Contact persons

For any questions including your stay at a hotel or any other information, please contact: - Tania Zamboni [email protected] +352 26 970 801 / +352 621 491 800 1 How to reach the meeting venue?

From Luxembourg AIRPORT by bus:

 Bus line N°16 or N°9 in direction of Centre - Gare http://www.vdl.lu/vdl_multimedia/PdfLigne16.pdf (Mo-Fr: from 5h30 am every 10 min / Su: from 6 am every 30 min) http://www.vdl.lu/vdl_multimedia/PdfLigne9.pdf (from 5h24 am Mo-Sa: every 15 min / Sunday: every 30 min) Neumünster  This ride takes maximum 30 minutes to Gare Centrale (Central Abbey Luxembourg Railway station)  Take bus line N°23 http://www.vdl.lu/vdl_multimedia/PdfLigne23.pdf (Mo-Fr: from 6h49 am every 30 minutes / Su: from 9h29 am until 7h29 pm every 60 min)  Get off at the bus stop Stadtgronn-Brék  This ride takes max 5 minutes  Walk over the little bridge, turn left twice, and you arrive at the Neumünster Abbey From Luxembourg RAILWAY STATION:

 Take bus line N°23 http://www.vdl.lu/vdl_multimedia/PdfLigne23.pdf (Mo-Fr: from 6h49 am every 30 minutes / Su: from 9h29 am until 7h29 Neumünster pm every 60 min) BusAbbey stop  Get off at the bus stop Stadtgronn-Brék. Stadtgronn-Brék  This ride takes max 5 minutes Bus stop Stadtgronn-Brék  Walk over the little bridge, turn lef twice, and you arrive at the Neumünster Abbey

By CAR If you come by car please contact [email protected]. It will be a pleasure to tell you where to park and how to come to the meeting venue.

2 HOTELS We provide you all information regarding the hotels in the surroundings of the meeting venue here below. To book your room please contact the hotel directly.

Walking distance to Price / night Hotel Address Contact Details Website hotel the meeting and person venue Tel: +352 22 04 93 Hotel 10 Place Guillaume II 850 m Fax: +352 22 04 96 90 - 140€ www.hotelvauban.lu Vauban L-1648 Luxembourg [email protected] 29, boulevard F.D. Tel: +352 22 19 75 Hotel Grand 1.0 km Roosevelt fax: +352 22 67 11 200 € www.hotelcravat.lu Cravat L-2450 Luxembourg [email protected] Tel: +352 27 47 37 www.hotel- Hotel Place 18 place d'Armes Fax: +352 27 47 38 205€ 1.1 km leplacedarmes.com/ d'armes L-1136 Luxembourg info@hotel- minimum en/home leplacedarmes.com www.sofitel.com/gb/ Tel: +352 248771 hotel-5555-sofitel- Hotel Sofitel 35, rue du Laboratoire 1.1 km Fax: +352 26480223 210 € luxembourg-le- centre-ville L-1911 Luxembourg [email protected] grand- ducal/index.shtml Tel: +352 47 45 34 Hotel 14, Place d’Armes 1.0 km Fax: +352 46 42 74 120 - 140€ www.hotelfrancais.lu Français L-1136 Luxembourg [email protected] www.accorhotels.co Hotel Tel: +352 248781 35, rue du Laboratoire m/gb/hotel-5556- Novotel City 1.1 km [email protected] 120 € L-1911 Luxembourg novotel-luxembourg- Center Fax: +352 26480224 centre/index.shtml Tel: +352 489 911 Hotel Avenue De La Liberte 28 www.goldentulipcen 1.2 km reservations@goldentuli 115 - 135€ Golden Tulip L-1930 Luxembourg tralmolitor.com pcentralmolitor.com Tel: +352 268 91 81 Avenue de la Gare 45- Park Inn by Fax: +352 2689 1899 www.parkinn.com/h 1.1 km 47 149 - 165€ Radisson info.luxembourg@rezido otel-luxembourg L-1611 Luxembourg rparkinn.com Tel. : +352 45 61 411 Group 5 avenue Marie-Thérèse Fax : +352 45 61 41 222 www.parcplaza.lu/uk Goeres - 1.6 km 100 - 130€ L-2132 Luxembourg reception.plaza@goeres- /index.php Park Plaza group.com HOTELS We provide you all information regarding the hotels in the surroundings of the meeting venue here below. To book your room please contact the hotel directly. Walking Price / distance to Hotel Address Contact Details night and Website hotel the meeting person venue Tel: +352 2627440 http://www.bestwestern Hotel Victor 3 avenue Victor Hugo Fax: +352 26864730 .de/hotels/Luxemburg/B 1.9 km 140 - 160€ Hugo L-1750 Luxemburg [email protected] EST-WESTERN-PLUS- western.de Grand-Hotel-Victor-Hugo 2, Boulevard de la Tel: + 352 40 21 01 Hôtel Le 1.6 km Pétrusse Fax: +352 40 36 66 115 - 125€ www.chatelet.lu/en Chatelet L-2320 Luxembourg [email protected] Alvisse Parc Route d'Echternach Tel: +352 43 56 43 0 4.1 km 89 - 107€ www.parc-hotel.lu Hotel L-1453 Luxembourg Fax: +352 43 69 03 Hotel- 36, rue des Tel: +352 44 23 56 Restaurant 4.0 km Septfontaines 105 € www.sieweburen.lu/en Fax: +352 44 23 53 Sieweburen L-2534 Luxembourg http://doubletree3.hilto n.com/en/hotels/luxemb Hotel Double 12 Rue Jean Engling Tel: +352-43-781 ourg/doubletree-by- 4.8 km 175 € Tree by Hilton L 1466 Luxembourg Fax: +352-43-6095 hilton-hotel-luxembourg- LXMHIDI/about/index.ht ml Tel: +352 27333-1 www.melia.com/en/hot Hotel Melia 10 Rue Fort Thuengen Fax: +352 27333-999 els/luxembourg/luxemb 2.7 km 150 € Kirchberg L-1499 Luxembourg melia.luxembourg@m ourg/melia- elia.com luxembourg/index.html Hotel Tel: +352 34 95 95 Single 22 ROUTE DE TREVES www.campanile- Campanile Fax: +352 34 94 95 room: 105€ 7.2 km SENNINGERBERG luxembourg- Luxembourg Luxembourg@campani Double L-2633 Luxembourg airport.lu/en/index.aspx (Airport) le.com room: 116€ www.accorhotels.com/g IBIS Route de Trèves Tel: +352 438801 b/hotel-0974-ibis- Luxembourg 6.0 km L-2632 Luxembourg Fax: +352 438802 78 - 100€ luxembourg- Airport Findel [email protected] aeroport/index.shtml www.nh- Tel. +352 340 571 NH Hotel 1 Route de Treves hotels.com/nh/en/hotels 7.0 km nhluxembourg@nh- 120 - 160€ Findel (Airport) L-1019 Luxembourg /luxembourg/luxembour hotels.com g/nh-luxembourg.html PROGRAMME

Tuesday, May 20th 2014 International Clinical Trials’ Day 09h30 Registration and coffee 10h00 – 10h15 Welcome and why are we here? Dr Christian Gluud, Denmark 10h15 – 10h30 What are ECRIN and ECRIN-ERIC? Director Jacques Demotes-Mainard, France 10h30 – 11h00 Relaunch of The James Lind Library. Sir Iain Chalmers, UK 11h00 – 11h30 Clinical studies with group sequential designs or adaptive designs: a user perspective. Prof Philip Hougaard, Lundbeck A/S, Denmark 11h30 – 11h45 Coffee break 11h45 – 12h15 Approaches to adaptive designs. Prof Peter Bauer, Austria 12h15 – 12h45 When are adaptive designs really needed? Prof Christopher Jennison, UK 12h45 – 13h15 Round table discussions on adaptive trial designs 13h15 – 14h45 Lunch and coffee 14h45 – 15h30 Credibility and bias in the results of clinical trials. Prof John P.A. Ioannidis, U.S.A. 15h30 – 16h00 Did the World Medical Association get their last revision of the Declaration of Helsinki right? Prof Silvio Garattini, Italy 16h00 – 16h15 Presentation of the ECRAN project. Dr Paola Mosconi, Italy 16h15 – 16h30 The ECRAN Film 17h30 – 19h00 Social Programme: Robert Schuman Circular Guided Walk http://www.lcto.lu/en/place/toursonrequest/schuman-circular-walk http://en.wikipedia.org/wiki/Robert_Schuman 19h30 Cultural Dinner @ Neumünster Abbey PROGRAMME

Wednesday, May 21st 2014

ECRAN Project Meeting

09:30 – 09:40 Welcome and introduction by the EU Commission. EU Commissioner. 09:40 – 09:50 Presentation of the ECRAN film. Dr Paola Mosconi, Italy and Dr Christian Gluud, DK. 09:50 – 10:10 The importance to promote independent clinical trials: where are the European researchers? Director Jacques Demotes-Mainard, ECRIN-ERIC. 10:10 – 10:30 Why evidence-based medicine is so important for designing clinical research and clinical practice. Editor-in-Chief David Tovey, The Cochrane Library, UK. 10:30 – 11:00 Transparency: an imperative in clinical research. Professor An-Wen Chan, Canada. 11:00 – 11:20 Coffee break 11:20 – 11:40 The ECRAN project: materials and tools. Dr Paola Mosconi, ECRAN. 11:40 – 12:10 Experiences from participation in design and promotion of randomised clinical trials: examples from patients’ organisations. Chair Brian West, EATG, Tamás Bereczky, EATG and invited speakers. 12:10 – 12:30 Impact of journals, web and social networks in promoting clinical trials. Clinical Editor Europe, Wim Weber, The BMJ, UK 12:30 – 13:00 General discussion. Paola Mosconi, Jacques Demotes-Mainard, and Christian Gluud. 13:00 – 14:00 Lunch 14:00 – 15:00 What are the bottlenecks in disseminating information on clinical trials and how can we blow up the bottlenecks? • Consumers’ and patients’ organisation. Invited speakers. • The European Network of Health Care Journalists. Senior Lecturer John Lister, UK. • The evidence-based community. Director Gerd Antes, Germany. • The clinical researchers. Professor Silvio Garattini, Italy • Testing Treatments. Sir Iain Chalmers, UK. 15:00 – 16:15 Five break out groups 16:15 – 16:45 How, when and who should speak about clinical trials? Report from the five break outs. Chairs: Jacques Demotes-Mainard, Paola Mosconi and Christian Gluud. GENERAL INFORMATION ABOUT Luxembourg Preparing your stay

Luxembourg (Grand Duchy of Luxembourg) is a country in the western Europe, bordered by , France and Germany. LANGUAGES National language: / Other languages: French, German and English TIME ZONE UTC/GMT +1 hour. Here a link to convert the time depending on your country of origin: Worldclock converter CURRENCY: The official currency is the Euro (EUR). CLIMATE: Like most of the Western Europe, Luxembourg has a moderate climate. The seasons are characterized by cool summers and cold, cloudy and humid winters. A nice time of the year to visit is spring (May to June) and autumn (September to October). For the festive period at the end of the year, the weather can also become dry, cold or snowy. ELECTRICITY: The voltage in Luxembourg is 220v and the standard European two-pin plug is used. North American and British travelers are advised to bring adaptors with them to Luxembourg as they are not widely available in the city. INVITATION LETTER VISA: For visa application, if you need conference invitation letter, please contact: [email protected]. Invitation letter will be issued to registered participants only. If you need more information about visa for your travel to Luxembourg, please see here: www.mae.lu EMERGENCY CALLS: Police Grand-Ducale: Phone 113 - www.police.lu Medical and fire rescue: Phone 112

Key facts about Luxembourg and further information as restaurants, please visit these websites: National Tourist Board (ONT): www.visitluxembourg.com/en Tourist Office (LCTO): www.lcto.lu www.lonelyplanet.com/luxembourg 7 8