reactions between antibodies and antigens for the detection of multiple drugs and drug moderate doses. However, it has also been shown that Buprenorphine has abuse potential and metabolites in human urine without the use of an instrument. may itself cause dependency. Subutex®, and a Buprenorphine/Naloxone combination product, Suboxone®, are the only two forms of Buprenorphine that have been approved by FDA in 2002 for AMPHETAMINE (AMP 1000) use in opioid addiction treatment. Buprenorphine was rescheduled from Schedule V to Schedule Amphetamine is a Schedule II controlled substance available by prescription (Dexedrine®) and is III drug just before FDA approval of Suboxone and Subutex. also available on the illicit market. Amphetamines are a class of potent sympathomimetic agents The BUP assay contained within the ECO CUP™ One Step Drug Test yields a positive result One Step Drug Test with therapeutic applications. They are chemically related to the human body's natural when the concentration of Buprenorphine in urine exceeds 10 ng/mL. Package Insert for Multi Drug Screen Test Cup catecholamines: epinephrine and norepinephrine. Acute higher doses lead to enhanced stimulation of the central nervous system and induce euphoria, alertness, reduced appetite, and a This Instruction Sheet is for testing of any combination of the following drugs: COCAINE (COC 300) sense of increased energy and power. Cardiovascular responses to Amphetamines include Cocaine is a potent central nervous system (CNS) stimulant and a local anesthetic. Initially, it AMP/BAR/BZO/BUP/COC/THC/MTD/mAMP/MDMA/MOR/OPI/OXY/PCP/PPX/TCA/EDDP/6-ACM increased blood pressure and cardiac arrhythmias. More acute responses produce anxiety, brings about extreme energy and restlessness while gradually resulting in tremors, over-sensitivity /COT/K2/KET/FEN/TRA/MDPV/ETG/ALCO paranoia, hallucinations, and psychotic behavior. The effects of Amphetamines generally last 2-4 and spasms. In large amounts, cocaine causes fever, unresponsiveness, difficulty in breathing and Including Adulterant Tests (Specimen Validity Tests) for: hours following use, and the drug has a half-life of 4-24 hours in the body. About 30% of unconsciousness. Oxidants (OX), Specific Gravity (S.G.), pH, Creatinine (CRE), Nitrite (NIT) and Glutaraldehyde (GLU). Amphetamines are excreted in the urine in unchanged form, with the remainder as hydroxylated Cocaine is often self-administered by nasal inhalation, intravenous injection and free-base A rapid, one step screening test for the simultaneous, qualitative detection of multiple drugs and and deaminated derivatives. smoking. It is excreted in the urine in a short time primarily as Benzoylecgonine.1.2 drug metabolites in human urine. The AMP 1000 assay contained within the ECO CUP™ One Step Drug Test yields a positive Benzoylecgonine, a major metabolite of cocaine, has a longer biological half-life (5-8 hours) than For Forensic Use Only result when the concentration of Amphetamine in urine exceeds 1,000 ng/mL. This is the cocaine (0.5-1.5 hours), and can generally be detected for 24-48 hours after cocaine exposure.2 suggested screening cut-off for positive specimens set by the Substance Abuse and Mental Health The COC 300 assay contained within the ECO CUP™ One Step Drug Test yields a positive INTENDED USE 3 Services Administration (SAMHSA, USA). result when the concentration of Benzoylecgonine in urine exceeds 300 ng/mL. This is the The ECO CUP™ One Step Drug Test is a lateral flow chromatographic immunoassay for the suggested screening cut-off for positive specimens set by the Substance Abuse and Mental Health qualitative detection of multiple drugs and drug metabolites in urine at the following cut-off AMPHETAMINE (AMP 500) Services Administration (SAMHSA, USA).3 concentrations: See AMPHETAMINE (AMP 1000) for the summary. The AMP 500 assay contained within the ECO CUP™ One Step Drug Test yields a positive Test Calibrator Cut-off COCAINE (COC 150) result when the concentration of Amphetamine in urine exceeds 500 ng/mL. See COCAINE (COC 300) for the summary. Amphetamine (AMP 1000) D-Amphetamine 1,000 ng/mL The COC 150 assay contained within the ECO CUP™ One Step Drug Test yields a positive 500 ng/mL Amphetamine (AMP 500) D-Amphetamine AMPHETAMINE (AMP 300) result when the concentration of Benzoylecgonine in urine exceeds 150 ng/mL. Amphetamine (AMP 300) D-Amphetamine 300 ng/mL See AMPHETAMINE (AMP 1000) for the summary. Barbiturates (BAR) Secobarbital 300 ng/mL The AMP 300 assay contained within the ECO CUP™ One Step Drug Test yields a positive MARIJUANA (THC 50) Benzodiazepines (BZO) Oxazepam 300 ng/mL result when the concentration of Amphetamine in urine exceeds 300 ng/mL. 9-tetrahydrocannabinol) is the primary active ingredient in cannabis (marijuana). When Buprenorphine (BUP) Buprenorphine 10 ng/mL smoked or orally administered, THC produces euphoric effects. Users have impaired short term BARBITURATES (BAR) Cocaine (COC 300) Benzoylecgonine 300 ng/mL memory and slowed learning. They may also experience transient episodes of confusion and Barbiturates are central nervous system depressants. They are used therapeutically as sedatives, anxiety. Long-term, relatively heavy use may be associated with behavioral disorders. The peak Cocaine (COC 150) Benzoylecgonine 150 ng/mL hypnotics, and anticonvulsants. Barbiturates are almost always taken orally as capsules or tablets. effect of marijuana administered by smoking occurs in 20-30 minutes and the duration is 90-120 9 50 ng/mL Marijuana (THC 50) -THC-9-COOH The effects resemble those of intoxication with alcohol. Chronic use of barbiturates leads to minutes after one cigarette. Elevated levels of urinary metabolites are found within hours of Marijuana (THC 20) 9-THC-9-COOH 20 ng/mL tolerance and physical dependence. Short acting Barbiturates taken at 400 mg/day for 2-3 months exposure and remain detectable for 3-10 days after smoking. The main metabolite excreted in the Methadone (MTD) Methadone 300 ng/mL can produce a clinically significant degree of physical dependence. Withdrawal symptoms 9-tetrahydrocannabinol-9-carboxylic acid (11-nor- 9-THC-9-COOH). experienced during periods of drug abstinence can be severe enough to cause death. Only a Methamphetamine (mAMP 1000) D-Methamphetamine 1,000 ng/mL The THC 50 assay contained within the ECO CUP™ One Step Drug Test yields a positive small amount (less than 5%) of most Barbiturates are excreted unaltered in the urine. 9 Methamphetamine (mAMP 500) D-Methamphetamine 500 ng/mL result when the concentration of 11-nor- -THC-9-COOH in urine exceeds 50 ng/mL. This is the The approximate detection time limits for Barbiturates are: suggested screening cut-off for positive specimens set by the Substance Abuse and Mental Health Methylenedioxymethamphetamine (MDMA) D,L-Methylenedioxymethamphetamine 500 ng/mL Short acting (e.g. Secobarbital) 100 mg PO (oral) 4.5 days Services Administration (SAMHSA, USA).3 Opiate (OPI 300, MOP, MOR) Morphine 300 ng/mL Long acting (e.g. Phenobarbital) 400 mg PO (oral) 7 days4 Opiate (OPI 2000) Morphine 2,000 ng/mL The BAR assay contained within the ECO CUP™ One Step Drug Test yields a positive result MARIJUANA (THC 20) Oxycodone (OXY) Oxycodone 100 ng/mL when the concentration of Secobarbital in urine exceeds 300 ng/mL. See MARIJUANA (THC 50) for the summary. Phencyclidine (PCP) Phencyclidine 25 ng/mL The THC 20 assay contained within the ECO CUP™ One Step Drug Test yields a positive BENZODIAZEPINES (BZO) result when the concentration of 11-nor- 9-THC-9-COOH in urine exceeds 20 ng/mL. Propoxyphene (PPX) Propoxyphene 300 ng/mL Benzodiazepines are medications that are frequently prescribed for the symptomatic treatment of Tricyclic Antidepressants (TCA) Nortriptyline 1,000 ng/mL anxiety and sleep disorders. They produce their effects via specific receptors involving a METHADONE (MTD) 2-Ethylidene-1,5-dimethyl-3,3-dipheylpyrrolidine (EDDP) 2-Ethylidene-1,5-dimethyl-3,3-dipheylpyrrolidine 300 ng/mL neurochemical called gamma aminobutyric acid (GABA). Because they are safer and more Methadone is a narcotic analgesic prescribed for the management of moderate to severe pain and 6-Acetylmorphine (6-ACM) 6-Acetylmorphine 10 ng/mL effective, Benzodiazepines have replaced barbiturates in the treatment of both anxiety and for the treatment of opiate dependence (heroin, Vicodin, Percocet, Morphine). The pharmacology Cotinine（COT） Cotinine 200 ng/mL insomnia. Benzodiazepines are also used as sedatives before some surgical and medical of oral Methadone is very different from IV Methadone. Oral Methadone is partially stored in the procedures, and for the treatment of seizure disorders and alcohol withdrawal. Synthetic Cannabinoid (K2 50) JWH -018 Pentanoic Acid / JWH-073 Butanoic Acid 50 ng/mL liver for later use. IV Methadone acts more like heroin. In most states you must go to a pain clinic Risk of physical dependence increases if Benzodiazepines are taken regularly (e.g., daily) for 20 ng/mL or a Methadone maintenance clinic to be prescribed Methadone. Methadone is a long acting pain Synthetic Cannabinoid (K2 20) JWH-018 Pentanoic Acid / JWH-073 Butanoic Acid more than a few months, especially at higher than normal doses. Stopping abruptly can bring on Ketamine (KET) Ketamine 1,000 ng/mL reliever producing effects that last from twelve to forty-eight hours. Ideally, Methadone frees the such symptoms as trouble sleeping, gastrointestinal upset, feeling unwell, loss of appetite, client from the pressures of obtaining illegal heroin, from the dangers of injection, and from the Fentanyl (FEN) Fentanyl 200 ng/mL sweating, trembling, weakness, anxiety and changes in perception. emotional roller coaster that most opiates produce. Methadone, if taken for long periods and at Tramadol (TRA) Tramadol 50 ng/mL Only trace amounts (less than 1%) of most Benzodiazepines are excreted unaltered in the urine; large doses, can lead to a very long withdrawal period. The withdrawals from Methadone are more Methylenedioxypyrovalerone (MDPV) Methylenedioxypyrovalerone 1,000 ng/mL most of the concentration in urine is conjugated drug. The detection period for the prolonged and troublesome than those provoked by heroin cessation, yet the substitution and Benzodiazepines in the urine is 3-7 days. Ethyl Glucuronide (ETG) Ethyl Glucuronide 300 ng/mL phased removal of methadone is an acceptable method of detoxification for patients and The BZO assay contained within the ECO CUP™ One Step Drug Test yields a positive result 4 Alcohol (ALCO) Alcohol >0.04% therapists. when the concentration of Oxazepam in urine exceeds 300 ng/mL. The MTD assay contained within the ECO CUP™ One Step Drug Test yields a positive result This assay provides only a preliminary qualitative test result. Use a more specific alternate when the concentration of Methadone in urine exceeds 300 ng/mL. quantitative analytical method to obtain a confirmed analytical result. Gas chromatography/mass BUPRENORPHINE (BUP) spectrometry (GC/MS) is the preferred confirmatory method.1 Apply clinical and professional Buprenorphine is a semisynthetic opioid analgesic derived from thebain, a component of opium. It METHAMPHETAMINE (mAMP 1000) PN: judgment to any drug of abuse test result, particularly when preliminary positive results are has a longer duration of action than morphine when indicated for the treatment of moderate to Methamphetamine is an addictive stimulant drug that strongly activates certain systems in the Y03 111 17405 obtained. severe pain, perioperative analgesia, and opioid dependence. Low doses buprenorphine produces brain. Methamphetamine is closely related chemically to amphetamine, but the central nervous sufficient agonist effect to enable opioid addicted individuals to discontinue the misuse of opioids system effects of Methamphetamine are greater. Methamphetamine is made in illegal laboratories SUMMARY AND EXPLANATION OF THE TEST without experiencing withdrawal symptoms. Buprenorphine carries a lower risk of abuse, and has a high potential for abuse and dependence. The drug can be taken orally, injected, or addiction, and side effects compared to full opioid agonists because of the “ceiling effect”, which inhaled. Acute higher doses lead to enhanced stimulation of the central nervous system and The ECO CUP™ One Step Drug Test is a competitive immunoassay utilizing highly specific means no longer continue to increase with further increases in dose when reaching a plateau at induce euphoria, alertness, reduced appetite, and a sense of increased energy and power. Cardiovascular responses to Methamphetamine include increased blood pressure and cardiac PHENCYCLIDINE (PCP) COTININE (COT) arrhythmias. More acute responses produce anxiety, paranoia, hallucinations, psychotic behavior, Phencyclidine, also known as PCP or Angel Dust, is a hallucinogen that was first marketed as a Cotinine is the first-stage metabolite of nicotine, a toxic alkaloid that produces stimulation of the and eventually, depression and exhaustion. The effects of Methamphetamine generally last 2-4 surgical anesthetic in the 1950's. It was removed from the market because patients receiving it autonomic ganglia and central nervous system when in humans. Nicotine is a drug to which hours and the drug has a half-life of 9-24 hours in the body. Methamphetamine is excreted in the became delirious and experienced hallucinations. virtually every member of a tobacco-smoking society is exposed whether through direct contact or urine as amphetamine and oxidized and delaminated derivatives. However, 10-20% of Phencyclidine is used in powder, capsule, and tablet form. The powder is either snorted or smoked second-hand inhalation. In addition to tobacco, nicotine is also commercially available as the Methamphetamine is excreted unchanged. Thus, the presence of the parent compound in the after mixing it with marijuana or vegetable matter. Phencyclidine is most commonly administered active ingredient in smoking replacement therapies such as nicotine gum, transdermal patches urine indicates Methamphetamine use. Methamphetamine is generally detectable in the urine for by inhalation but can be used intravenously, intra-nasally, and orally. After low doses, the user and nasal sprays. 3-5 days, depending on urine pH level. thinks and acts swiftly and experiences mood swings from euphoria to depression. Self-injurious In a 24-hour urine, approximately 5% of a nicotine dose is excreted as unchanged drug with 10% The mAMP 1000 assay contained within the ECO CUP™ One Step Drug Test yields a positive behavior is one of the devastating effects of phencyclidine. as cotinine and 35% as hydroxycotinine; the concentrations of other metabolites are believed to result when the concentration of Methamphetamine in urine exceeds 1,000 ng/mL. PCP can be found in urine within 4 to 6 hours after use and will remain in urine for 7 to 14 days, account for less than 5%.1 While cotinine is thought to be an inactive metabolite, it’s elimination depending on factors such as metabolic rate, user's age, weight, activity, and diet.5 Phencyclidine is profile is more stable than that of nicotine which is largely urine pH dependent. As a result, METHAMPHETAMINE (mAMP 500) excreted in the urine as an unchanged drug (4% to 19%) and conjugated metabolites (25% to 30%).6 cotinine is considered a good biological marker for determining nicotine use. The plasma half-life See METHAMPHETAMINE (mAMP 1000) for the summary. The PCP assay contained within the ECO CUP™ One Step Drug Test yields a positive result of nicotine is approximately 60 minutes following inhalation or parenteral administration.2 Nicotine The mAMP 500 assay contained within the ECO CUP™ One Step Drug Test yields a positive when the concentration of Phencyclidine in urine exceeds 25 ng/mL. This is the suggested and cotinine are rapidly eliminated by the kidney; the window of detection for cotinine in urine at a result when the concentration of Methamphetamine in urine exceeds 500 ng/mL. screening cut-off for positive specimens set by the Substance Abuse and Mental Health Services cutoff level of 200 ng/mL is expected to be up to 2-3 days after nicotine use. Administration (SAMHSA, USA).3 The COT assay contained within the ECO CUP™ One Step Drug Test yields a positive result METHYLENEDIOXYMETHAMPHETAMINE (MDMA) when the concentration of Cotinine in urine exceeds 200 ng/mL. Methylenedioxymethamphetamine (ecstasy) is a designer drug first synthesized in 1914 by a PROPOXYPHENE (PPX) 8 German drug company for the treatment of obesity. Those who take the drug frequently report Propoxyphene is a mild narcotic analgesic found in various pharmaceutical preparations, usually SYNTHETIC CANNABINOIDS (K2 50) adverse effects, such as increased muscle tension and sweating. MDMA is not clearly a stimulant, as the hydrochloride or napsylate salt. These preparations typically also contain large amounts of Since 2004, herbal mixtures such as “Spice” have been sold in Switzerland, Austria, Germany and although it has, in common with amphetamine drugs, a capacity to increase blood pressure and acetaminophen, aspirin, or caffeine. Peak plasma concentrations of propoxyphene are achieved other European countries mainly via Internet shops. Although declared as incense, they are heart rate. MDMA does produce some perceptual changes in the form of increased sensitivity to from 1 to 2 hours post dose. In the case of overdose, propoxyphene blood concentrations can smoked as “bio-drugs” by the consumers. In corresponding blogs, drug users reported light, difficulty in focusing, and blurred vision in some users. Its mechanism of action is thought to reach significantly higher levels. In human, propoxyphene is metabolized by N-demethylation to cannabis-like effects after smoking. These products enjoy great popularity particularly among be via release of the neurotransmitter serotonin. MDMA may also release dopamine, although the yield norpropoxyphene. Norpropoxyphene has a longer half-life (30 to 36 hours) than parent younger people, as up to now the mixtures are sold in head shops and via internet in many 10 general opinion is that this is a secondary effect of the drug (Nichols and Oberlender, 1990). The propoxyphene (6 to 12 hours). The accumulation of norpropoxyphene seen with repeated doses countries without age restriction. most pervasive effect of MDMA, occurring in virtually all people who took a reasonable dose of the may be largely responsible for resultant toxicity. JWH-018 was developed and evaluated in basic scientific research to study structure activity 11 drug, was to produce a clenching of the jaws. The PPX assay contained within the ECO CUP™ One Step Drug Test yields a positive result relationships related to the cannabinoid receptors. JWH-073 has been identified in numerous 12 The MDMA assay contained within the ECO CUP™ One Step Drug Test yields a positive when the concentration of Propoxyphene or Norpropoxyphene in urine exceeds 300 ng/mL. herbal products, such as “Spice”, “K2”, and “K3”. These products may be smoked for their result when the concentration of Methylenedioxymethamphetamine in urine exceeds 500 ng/mL. psychoactive effects. TRICYCLIC ANTIDEPRESSANTS (TCA) The K2 50 assay contained within the ECO CUP™ One Step Drug Test yields a positive result OPIATE (OPI 300, MOR, MOP) Tricyclic Antidepressants (TCA) are commonly used for the treatment of depressive disorders. when the concentration of Synthetic Cannabinoid compounds in urine exceeds 50 ng/mL. Opiate refers to any drug that is derived from the opium poppy, including the natural products, TCA overdoses can result in profound central nervous system depression, cardiotoxicity and morphine and codeine, and the semisynthetic drugs such as heroin. Opioid is more general, anticholinergic effects. TCA overdose is the most common cause of death from prescription drugs. SYNTHETIC CANNABINOIDS (K2 20) referring to any drug that acts on the opioid receptor. Opioid analgesics comprise a large group of TCAs are taken orally or sometimes by injection. TCAs are metabolized in the liver. Both TCAs See SYNTHETIC CANNABINOIDS (K2 50) for the summary. substances which control pain by depressing the central nervous system. Large doses of and their metabolites are excreted in urine mostly in the form of metabolites for up to ten days. The K2 20 assay contained within the ECO CUP™ One Step Drug Test yields a positive result morphine can produce higher tolerance levels, physiological dependency in users, and may lead The TCA assay contained within the ECO CUP™ One Step Drug Test yields a positive result when the concentration of Synthetic Cannabinoid compounds in urine exceeds 20 ng/mL. to substance abuse. Morphine is excreted unmetabolized, and is also the major metabolic product when the concentration of Nortriptyline in urine exceeds 1,000 ng/mL. of codeine and heroin. Morphine is detectable in the urine for several days after an opiate dose.4 KETAMINE (KET) The OPI 300 assay contained within the ECO CUP™ One Step Drug Test yields a positive 2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHEYLPYRROLIDINE (EDDP) Ketamine is a short-acting “dissociative” anesthetic due to its ability to separate perception from result when the concentration of Morphine in urine exceeds 300 ng/mL. EDDP is an immunoassay based on the principle of competitive binding. Drugs which may be sensation. It also has hallucinogenic and painkilling qualities that seem to affect people in very present in the urine specimen compete against the drug conjugate for binding sites on the different ways. Ketamine is chemically related to PCP (Angel Dust). Ketamine is occasionally OPIATE (OPI 2000) antibody. administered to people but, more commonly, is used by vets for pet surgery. Generally street K is Opiate refers to any drug that is derived from the opium poppy, including the natural products, During testing, a urine specimen migrates upward by capillary action. EDDP, if present in the urine most often diverted in liquid form from vets’ offices or medical suppliers. Ketamine generally takes morphine and codeine, and the semisynthetic drugs such as heroin. Opioid is more general, specimen below 300 ng/mL, will not saturate the binding sites of antibody coated particles in the 1-5 minutes to take effect. Snorted ketamine takes a little longer at 5-15 minutes. Depending on referring to any drug that acts on the opioid receptor. Opioid analgesics comprise a large group of test device. The antibody coated particles will then be captured by immobilized EDDP conjugate how much and how recently one has eaten, oral ketamine can take between 5 and 30 minutes to substances which control pain by depressing the central nervous system. Large doses of and a visible colored line will show up in the test line region. The colored line will not form in the take effect. The primary effects of ketamine last approximately an 30-45 minutes if injected, 45-60 morphine can produce higher tolerance levels, physiological dependency in users, and may lead test line region if the EDDP level exceeds 300 ng/mL because it will saturate all the binding sites minutes when snorted, and 1-2 hours if used orally. The Drug Enforcement Administration reports to substance abuse. Morphine is excreted unmetabolized, and is also the major metabolic product of anti-EDDP antibodies. A drug-positive urine specimen will not generate a colored line in the test that the drug can still affect the body for up to 24 hours. of codeine and heroin. Morphine is detectable in the urine for several days after an opiate dose.4 line region, while a drug-negative urine specimen or a specimen containing a drug concentration The KET assay contained within the ECO CUP™ One Step Drug Test yields a positive result The OPI 2000 assay contained within the ECO CUP™ One Step Drug Test yields a positive less than the cut-off will generate a line in the test line region. To serve as a procedural control, a when the concentration of Ketamine in urine exceeds 1,000 ng/mL. result when the concentration of Morphine in urine exceeds 2,000 ng/mL. This is the suggested colored line will always appear at the control line region indicating that proper volume of specimen screening cut-off for positive specimens set by the Substance Abuse and Mental Health Services has been added and membrane wicking has occurred. FENTANYL (FEN) Fentanyl is a potent, synthetic opioid analgesic with a rapid onset and short duration of action.13 It is Administration (SAMHSA, USA).3 The EDDP assay contained within the ECO CUP™ One Step Drug Test yields a positive result when the concentration of 2-Ethylidene-1,5-Dimethyl-3,3-Dipheylpyrrolidine in urine exceeds 300 OXYCODONE (OXY) ng/mL. and is commonly used in pre-procedures as a pain reliever as well as an anesthetic in combination O x ycodone,[4 ,5-e poxy-1 4-h ydroxy- 3 - metho xy-17-meth y l -mor phi nan - 6 - one , with a benzodiazepine. Fentanyl is approximately 80 to 100 times more potent than morphine and 14,15 6-ACETYLMORPHINE (6-ACM) roughly 15 to 20 times more potent than heroin. Fentanyl and its derivatives are used dihydrohydroxycodeinone] is a semisynthetic opioid agonist derived from thebaine, a constituent 16 of opium. Oxycodone is a Schedule II narcotic analgesic and is widely used in clinical medicine. 6-Acetylmorphine (6-ACM) is one of three active metabolites of heroin (diacetylmorphine), the recreationally. Deaths have resulted from both recreational and improper medical use. The pharmacology of oxycodone is similar to that of morphine, in all respects, including its abuse others being morphine and the much less active 3-acetylmorphine (3-ACM). 6-ACM is rapidly The FEN assay contained within the ECO CUP™ One Step Drug Test yields a positive result when and dependence liabilities. Pharmacological effects include analgesia, euphoria, feelings of created from heroin in the body, and then is either metabolized into morphine or excreted in the the concentration of Fentanyl in urine exceeds 200 ng/mL relaxation, respiratory depression, constipation, papillary constriction, and cough suppression. urine. Since 6-ACM is a unique metabolite to heroin, its presence in the urine confirms that heroin Oxycodone is prescribed for the relief of moderate to high pain under pharmaceutical trade names was the opioid used. This is significant because in a urine immunoassay drug screen, the test TRAMADOL (TRA) as OxyContin® (controlled release), OxyIR®, OxyFast® (immediate release formulations), or typically tests for morphine, which is a metabolite of a number of legal and illegal opiates/opioids Percodan® (aspirin) and Percocet® (acetaminophen) that are in combination with other such as codeine, morphine sulphate, and heroin. 6-ACM remains in the urine for no more than 24 nonnarcotic analgesics. Oxycodone's behavioral effects can last up to 5 hours. The hours so a urine specimen must be collected soon after the last heroin use, but the presence of controlled-release product, OxyContin®, has a longer duration of action (8-12 hours). 6-ACM guarantees that heroin was in fact used as recently as within the last day. The OXY assay contained within the ECO CUP™ One Step Drug Test yields a positive result The 6-ACM assay contained within the ECO CUP™ One Step Drug Test yields a positive The TRA assay contained within the ECO CUP™ One Step Drug Test yields a positive result when the concentration of Oxycodone in urine exceeds 100ng/mL. result when the concentration of 6-Acetylmorphine in urine exceeds 10 ng/mL. when the concentration of Tramadol in urine exceeds 50 ng/mL. METHYLENEDIOXYPYROVALERONE (MDPV) Oxidants (OX): Tests for the presence of oxidizing agents such as bleach and peroxide in the urine. “Bath salts”, a form of designer drugs, also promoted as “plant food” or “research chemicals”, is sold 8,9 mainly in head shops, on the Internet, and at other retail locations. Designer drugs were developed from 1.003 to 1.030. Specific gravity levels of less than 1.003 or higher than 1.030 may be an contaminated with blood , the use of gloves is recommended to avoid unnecessary contact in recent years to subvert law enforcement and drug testing agencies and are advertised as “legal” indication of adulteration or specimen dilution. with the specimen. highs. The technical term for “bath salts” is substituted cathinone. Substituted cathinones are synthetic, concentrated versions of the stimulant chemical in Khat. Khat is a plant that is cultivated in the range of 4.0 to 9.0. Values below pH 4.0 or above pH 9.0 may indicate the sample has regulations. and used in East Africa and the Middle East. It has a stimulant effect on the user and can be quite been altered. dangerous. The white crystals resemble legal bathing salts, thus the name of “bath salts”. In 2009 specimens STORAGE AND STABILITY and 2010 there was a significant rise in the abuse of synthetic cathinones, initially in the United should contain no trace of nitrite. Positive results for nitrite usually indicate the presence of an Kingdom and the rest of Europe, and subsequently in the US and Canada. adulterant. Store as packaged in the sealed pouch at 2-30oC (36-86oF). The test is stable through the Established as one of the main ingredients for “bath salts”, among other synthetic stimulants like found in a expiration date printed on the sealed pouch. The test cup must remain in the sealed pouch until Mephedrone, Methylone, Butylone and Methadrone, MDPV started appearing around 2004 when it urine specimen. Detection of glutaraldehyde in a specimen is generally an indicator of use. DO NOT FREEZE. Do not use beyond the expiration date. was popularized as a club drug, often used in combination with alcohol, GHB, cannabis and other adulteration. abused drugs, for its desired effects such as euphoria, alertness, talkativeness, and sexual arousal. SPECIMEN COLLECTION AND PREPARATION There are currently no prescribed used for the synthetic stimulants. common mechanisms used in an attempt to circumvent drug testing. Low creatinine may While synthetic stimulants appear to affect users in ways similar to amphetamines, ecstasy and indicate dilute urine. Urine Assay cocaine, reports concerning aggression, tachycardia, paranoia and suicide suggest that they may The urine specimen shoud be collected into the test cup. Urine collected at any time of the day may be be more acutely toxic. These negative effects have resulted in an increase of ER visits and PRINCIPLE used. If the urine specimen is collected for later testing, another dry and clean container must be used to hospitalizations, severe psychotic and violent episodes, self-inflicted wounds, suicide and an collect the specimen. Urine specimens exhibiting visible precipitates should be allowed to settle to obtain alarming increase in abuse-related deaths. U.S. Poison Control and National Drug Intelligence have (1) ECO CUP™ One Step Drug Test is an immunoassay based on the principle of competitive a clear specimen for testing. all issued health warnings, noting nationwide emergency room visits related to these drugs. In binding. Drugs which may be present in the urine specimen compete against their respective drug October 2011, the DEA announced an emergency ban on MDPV, Methylone and Mephedrone, conjugate for binding sites on their specific antibody. SPECIMEN STORAGE making testing for these substances more vital than ever. During testing, a urine specimen migrates upward by capillary action. A drug, if present in the urine The MDPV assay contained within the ECO CUP™ One Step Drug Test yields a positive result specimen below its cut-off concentration, will not saturate the binding sites of its specific antibody. Urine specimens may be stored at 2-8°C (36-46°F) for up to 48 hours prior to testing. For prolonged when the concentration of Methylenedioxypyrovalerone in urine exceeds 1,000 ng/mL. The antibody will then react with the drug-protein conjugate and a visible colored line will show up storage, specimens may be frozen and stored below -20°C. Frozen specimens should be thawed and in the test line region of the specific drug strip. The presence of drug above the cut-off mixed well before testing. concentration will saturate all the binding sites of the antibody. Therefore, the colored line will not ETHYL GLUCURONIDE (ETG) form in the test line region. MATERIALS Ethyl Glucuronide (EtG) is a direct metabolite of ethanol, which is formed by enzymatic conjugation 20,21 A drug-positive urine specimen will not generate a colored line in the specific test line region of the of ethanol with glucuronic acid. Alcohol in urine is normally detected for only a few hours, Materials Provided whereas EtG can be detected up to several days even after complete elimination of alcohol from strip because of drug competition, while a drug-negative urine specimen will generate a line in the the body.22 Therefore, EtG can be a useful diagnostic biomarker for determining recent alcohol use test line region because of the absence of drug competition.

and in monitoring abstinence in alcoholics in alcohol withdrawal treatment programs.23-26 Ethanol To serve as a procedural control, a colored line will always appear at the control line region, can be produced in vitro due to fermentation of urine samples containing sugars, bacteria or yeast indicating that proper volume of specimen has been added and membrane wicking has occurred. Materials Required But Not Provided when samples are exposed to warm temperatures.27 In such cases, EtG test can be used, as a confirmatory test to determine if the alcohol in the sample is due to consumption of alcohol or it is (2) Alcohol test is based on the high specifity of alcohol oxidase (ALOx) for ethyl alcohol in the formed in vitro as a result of fermentation. Currently EtG is monitor by GC/MS and LC/MS/MS.28,29 presence of peroxidase and enzyme substrate such as tetramethylbenzidine (TMB) as shown in DIRECTIONS FOR USE Ethyl glucuronide (EtG) is a minor non-oxidative metabolite of ethyl alcohol formed by the in vivo the following: conjugation of ethanol with glucuronic acid with UDP glucuronosyltransferase. EtG is a product of ALOX/Peroxidase Allow the test cup, and urine specimen to come to room temperature [15-30°C (59-86°F)] prior to testing. metabolic process of ingested alcohol (ethanol) rapidly metabolized in the body, which is excrete in EtOH + TMB CH3CHO + Colored TMB the blood, hair and urine. By using, the ECO Ⅱ CUP™ One Step Drug Test EtG can be detect The distinct color on reactive pad could be observed in less than 60 seconds after the reaction pad 1) Tear the foil pouch open, remove test cup, and donor needs to obtain their own disposable gloves. in urine, confirming the consumption of alcohol. The EtG metabolite remains in the body longer and was wetted with urine specimens with the ethyl alcohol concentration greater than 0.04%. It should Label the test cup with donor information. (Fig. 1) therefore has a more useful window of detection of 8 to 80 hours. EtG testing is an excellent option be pointed out that other alcohols such as methyl, propanyl and allyl alcohol would develop the 2) Wear disposable gloves to collect urine specimen. Open test cup lid. Urinate directly into the for zero-tolerance alcohol consumption or for rehabilitation programs. similar color on the reactive pad. However, these alcohols are not normally present in human urine. test cup. Be sure to fill up the test cup with the urine specimen between minimum 30mL to The EtG assay contained within the ECO CUP™ One Step Drug Test yields a positive maximum 90mL (marked on the cup). (Fig. 2) result when the concentration of Ethyl Glucuronide in urine exceeds 300 ng/mL. REAGENTS 3) After urine specimen has been collected, close the lid securely and return cup to collection official. (Fig. 3) 4) The collection official will use newly obtained gloves to peel off the label to reveal test results. Read (1) The test contains a membrane strip coated with drug-protein conjugates (purified bovine ALCOHOL (ALCO) results of alcohol test at 2 minutes, adulterant test at 3 minutes, and drug tests at 5 minutes. DO NOT Excess or inappropriate consumption of alcohol is a common and pervasive social problem. It is a albumin) on the test line, a goat polyclonal antibody against gold-protein conjugate at the control INTERFERET ALCOHOL AND ADULTERANT TEST RESULTS AFTER 5 MINUTES AND DRUG contributory factor to many accidents, injuries and medical conditions. Urine alcohol test is line, and a dye pad which contains colloidal gold particles coated with mouse monoclonal antibody TESTS RESULTS AFTER 10 MINUTES. (Fig. 4) intended for use as a rapid method to detect the presence of alcohol in urine greater than 0.04%. specific to individual drug on the list in the “Intended Use ” section. To confirm the concentration of positive specimens, an alternate, non-enzymatic technology such (2) The alcohol pad contains tetramethylbenzidine, alcohol oxidaze, peroxidase, buffer and as headspace gas chromatography should be used. stabilizing proteins. ADULTERANT TESTS (SPECIMEN VALIDITY TESTS) REAGENTS ADULTERANT TESTS (SPECIMEN VALIDITY TESTS) SUMMARY 5 The adulterant test strip contains chemically treated reagent pads. Observation of the color change Adulteration Pad Reactive Indicator Buffers and Non-reactive Ingredients on the strip compared to the color chart provides a semi-quantitative screen for oxidants, specific Oxidants (OX) 0.36% 99.64% gravity, pH, creatinine, nitrite and glutaraldehyde in human urine which can help to assess the Specific Gravity (S.G.) 0.25% 99.75% (Fig. 1) (Fig. 2) integrity of the urine specimen. pH 0.06% 99.94% (Fig. 3) Nitrite (NIT) 0.07% 99.93% ADULTERATION Glutaraldehyde (GLU) 0.02% 99.98% Creatinine (CRE) 0.04% 99.96% PN: Adulteration is the tampering of a urine specimen with the intention of altering the test results. The Y03 111 17405 use of adulterants in the urine specimen can cause false negative results by either interfering with PRECAUTIONS the test and/or destroying the drugs present in the urine. Dilution may also be used to produce false negative drug test results. To determine certain urinary characteristics such as specific gravity C C C and pH, and to detect the presence of oxidants, nitrite, glutaraldehyde and creatinine in urine are T T T considered to be the best ways to test for adulteration or dilution. (Fig. 4) NEGATIVE POSITIVE INVALID 9. There is a possibility that technical or procedure error for alcohol test as well other substances PCP THC 20 AMP 300 mAMP OPI 300 OPI 2000 COC K2 20 K2 50 INTERPRETATION OF RESULTS Analyte Pos Ne g Pos Neg Pos Neg in certain foods and medicines may interfere with the test and cause false results. Please refer Pos Neg Pos Neg Pos Neg Pos Neg Pos Neg Pos Neg Negative Samples 0 1 0 40 0 42 0 4 0 3 0 17 0 0 (Please refer to the previous illustration) to “Analytical Specificity” section for alcohol test list of substances that will interfere the test Near Cut-off Negative 1 22 1 20 Samples [ between 50% 0 0 0 3 1 6 0 10 0 11 1 13 0 13 NEGATIVE: Two lines appear. * One color line should be in the control region (C), and another results. of cut-off and cut-off ] apparent color line adjacent should be in the test region (T). This negative result indicates that the 10.Alcohol test is a semi-quantitative assay. It identifies alcohol in human urine specimens at a Near Cut-off Positive Samples [ between cut- 7 2 3 0 3 0 3 1 18 1 3 0 26 1 drug concentration is below the detectable level. concentration of 0.04% or higher. off and 150% of cut-off ] 37 0 39 0 Positive Samples *NOTE: The shade of color in the test line region (T) will vary, but it should be considered negative [>150% of cut-off ] 28 0 47 0 40 0 22 0 7 0 6 0 0 0 whenever there is even a faint distinguishable color line. Agreement with GC/MS 95% >99%>99% >99% >99% 98% 96% >99%96% >99%>99% 97% 96% >99%>97% >99%>97%>99% POSITIVE: One color line appears in the control region (C). No line appears in the test region (T). PERFORMANCE CHARACTERISTICS This positive result indicates that the drug concentration is above the detectable level. AMP PPX EDDP BUP COC150 mAMP500 AMP500 6-ACM ETG COT Analyte INVALID: Control line fails to appear. Insufficient specimen volume or incorrect procedural Pos Neg Pos Neg Pos Neg Pos Neg Pos Neg Pos Neg Pos Neg Pos Neg Pos Neg Pos Neg techniques are the most likely reasons for control line failure. Review the procedure and repeat Accuracy Negative Samples 0 1 0 20 0 20 0 20 0 40 0 42 0 20 0 20 0 70 the test using a new test cup. If the problem persists, discontinue using the lot immediately and In the comparison study, the ECO CUP™ One Step Drug Test was compared to a GC/MS Near Cut-off Negative 0 185 Samples [ between 50% 0 19 1 19 2 18 2 18 0 6 0 6 2 18 0 20 0 70 contact your supplier. reference method to determine its accuracy. Clinical urine samples were collected for each of the of cut-off and cut-off ] drug types list on the following table. Clinical specimens were quantified by GC/MS analysis Near Cut-off Positive Samples [ between cut- 7 1 18 2 19 1 17 3 4 0 11 0 20 0 19 1 70 0 (Please refer to the alcohol color chart) before testing. off and 150% of cut-off ] 103 12 Positive Samples 51 Alcohol Test Results [>150% of cut-off ] 13 0 20 0 20 0 20 0 0 31 0 20 0 20 0 70 0 NEGATIVE: Almost no color change by comparing with the background. The negative result Agreement with GC/MS 95%>99%95%98%98%95%93%95%>99%>99%>99%>99%>99%95%98%>99%>99%>99% >99%94% indicates that the alcohol concentration is less than 0.04%. Test Compounds Contributed to the Totals of GC/MS POSITIVE: A distinct color developed all over the pad. The positive result indicates that the urine AMP Amphetamine alcohol concentration is 0.04% or higher. BAR Secobarbital, Butalbital, Phenobarbital, Pentobarbital INVALID: The test should be considered invalid if only the edge of the reactive pad turned color BZO Oxazepam, Nordiazepam, α -OH-Alprazolam, Desalkylflurazepam Reproducibility Reproducibility studies were carried out using commercially available stock solutions of the drug that might be attributed to insufficient sampling. The subject should be retested. BUP Buprenorphine COC Benzoylecgonine analytes listed. Dilutions were made from the stock solution of each drug to the concentrations 9 specified in the following tables. The results are listed in the following tables. ADULTERANT TESTS (SPECIMEN VALIDITY TESTS) INTERPRETATION THC -tetrahydrocannabinol-9-carboxylic acid MTD Methadone (Please refer to the color chart) Methamphetamine mAMP AMPHETAMINE (AMP 1000) Semi-quantitative results are obtained by visually comparing the reacted color blocks on the strip MDMA D,L-Methylenedioxymethamphetamine, Methylenedioxyamphetamine to the printed color indicator on the color chart. No instrumentation is required. OPI, MOR Morphine, Codeine Amphetamine Total number of Result Precision OXY Oxycodone conc.(ng/mL) Determinations ADULTERANT TESTS (SPECIMEN VALIDITY TESTS) LIMITATIONS PCP Phencyclidine No drug present 40 40 negative >99% PPX Propoxyphene 500 40 40 negative >99% 1. The adulterant tests included with the product are meant to aid in the determination of TCA Nortriptyline 750 40 40 negative >99% abnormal specimens, but may not cover all the possible adulterants. EDDP 2-Ethylidene-1,5-Dimethyl-3,3-Dipheylpyrrolidine 1,000 40 40 positive >99% 2. Oxidants: Normal human urine should not contain oxidants. The presence of high level of antioxidants in 6-ACM 6-Acetylmorphine the specimen, such as ascorbic acid, may result in false negative results for the oxidants pad. COT Cotinine 1,500 40 40 positive >99% 3. Specific Gravity: Elevated levels of protein in urine may cause abnormally high specific gravity values. K2 JWH-018 Pentanoic Acid / JWH-073 Butanoic Acid 4. Nitrite: Nitrite is not a normal component of human urine. However, nitrite found in urine may KET Ketamine indicate urinary tract infections or bacterial infections. Nitrite levels of > 20mg/dL may produce FEN Fentanyl AMPHETAMINE (AMP 500) false positive glutaraldehyde results. TRA Tramadol Amphetamine Total number of Result Precision 5. Glutaraldehyde: Is not normally found in a urine specimen. However certain metabolic MDPV Methylenedioxypyrovalerone conc.(ng/mL) Determinations abnormalities such as ketoacidosis (fasting, uncontrolled diabetes or high-protein diets) may ETG Ethyl Glucuronide No drug present 40 40 negative >99% interfere with the test results. 250 40 40 negative >99% 6. Creatinine: Tests for the specimen for dilution and flushing. Normal creatinine levels are between 750 40 40 positive >99% 20 and 350mg/dL. Under rare conditions, certain kidney diseases may show dilute urine. The following results are tabulated from these clinical studies: 1,000 40 40 positive >99% % Agreement with GC/MS (HPLC for TCA, Predicate Device for COT and KET) QUALITY CONTROL AMPHETAMINE (AMP 300) A procedural control is included in the test. A color line appearing in the control region (C) is AM P mAMP OPI 2000 OPI 300 COC PCP AMP300 COC150 THC20 mAMP500 6-ACM BAR TCA considered an internal procedural control. It confirms sufficient specimen volume, adequate Amphetamine Total number of Result Precision Positive conc.(ng/mL) Determinations membrane wicking and correct procedural technique. Agreement 95% 96% >99% 96% 96% 95% >99% >99% >99% >99% 98% 97% 98% Negative No drug present 60 60 negative >99% Agreement >99% >99% 97% >99% >99% >99% 98% >99% >99% >99% >99% 98% >99% LIMITATIONS 150 30 30 negative >99% Overall 98% 98% 98% 98% 98% 95% 99% >99% >99% >99% 99% 98% 99% Agreement 225 15 15 negative >99% 1. The ECO CUP™ One Step Drug Test provides only a qualitative, preliminary analytical result. 375 15 15 positive >99% A secondary analytical method must be used to obtain a confirmed result. Gas MDMA BZO MTD OXY EDDP THC PPX BUP AMP500 COT K2 50 K2 20 KET ETG 450 30 30 positive >99% chromatography/mass spectrometry (GC/MS) is the preferred confirmatory method. 3,4,7 Positive 93% 96% 94% 95% 98% 96% 95% 93% >99% >97% >99% >99% 600 30 30 positive >99% 2. There is a possibility that technical or procedural errors, as well as other interfering substances Agreement >99% >97% Negative in the urine specimen may cause erroneous results. Agreement >99% >99% 98% >99% 95% >99% 98% 95% 95% 94% >99% >99% >99% >99% 3. Adulterants, such as bleach and/or alum, in urine specimens may produce erroneous results Overall 96% 98% 96% 98% 96% 98% 96% 94% 98% 96% 98% 98% >99% >99% BARBITURATES (BAR) regardless of the analytical method used. If adulteration is suspected, the test should be Agreement repeated with another urine specimen and a new test cup. Secobarbital Total number of Result Precision BAR MDMA BZO MTD OXY TCA THC KET conc.(ng/mL) Determinations 4. A positive result does not indicate intoxication of the donor, the concentration of drug in the Analyte urine, or the route of drug administration. Pos Ne g Pos Neg Pos Neg Pos Neg Pos Neg Pos Neg Pos Neg Pos Neg No drug present 40 40 negative >99% Negative Samples 0 4 0 4 0 5 0 3 0 4 0 4 0 0 5. A negative result may not necessarily indicate drug-free urine. Negative results can be obtained Near Cut-off Negative 0 270 150 40 40 negative >99% Samples [ between 50% 1 37 0 36 0 28 1 44 0 36 0 36 0 15 when drug is present but below the cut-off level of the test. of cut-off and cut-off ] 225 40 40 negative >99% 6. Test does not distinguish between drugs of abuse and certain medications. Near Cut-off Positive Samples [ between cut- 34 1 33 3 27 2 27 2 34 2 35 1 23 1 300 40 40 positive >99% 7. A positive test result may be obtained from certain foods or food supplements. off and 150% of cut-off ] 274 1 Positive Samples 450 40 40 positive >99% 8. Alcohol test is designed for use with human urine only. A positive result indicates only the [>150% of cut-off ] 3 0 4 0 18 0 3 0 4 0 4 0 1 0 presence of alcohol and does not indicate or measure intoxication. Agreement with GC/MS 97% 98% 93% >99% 96% >99% 94% 98% 95% >99% 98% >99% 96% >99%>99% >99% BENZODIAZEPINES (BZO) METHAMPHETAMINE (mAMP 1000) PHENCYCLIDINE (PCP)

Oxazepam Total number of Result Precision Methamphetamine Total number of Result Precision Phencyclidine Total number of Result Precision conc.(ng/mL) Determinations conc.(ng/mL) Determinations conc.(ng/mL) Determinations No drug present 40 40 negative >99% No drug present 40 40 negative >99% No drug present 40 40 negative >99% 150 40 40 negative >99% 500 40 40 negative >99% 12.5 40 40 negative >99% 225 40 40 negative >99% 750 40 40 negative >99% 19 40 40 negative >99% 300 40 40 positive >99% 1,000 40 40 positive >99% 25 40 40 positive >99% 450 40 40 positive >99% 1,500 40 40 positive >99% 37.5 40 40 positive >99%

TRICYCLIC ANTIDEPRESSANTS (TCA) COCAINE (COC 300) METHAMPHETAMINE (mAMP 500) Nortriptyline Total number of Result Precision Benzoylecgonine Total number of Result Precision Methamphetamine Total number of Result Precision conc.(ng/mL) Determinations conc.(ng/mL) Determinations conc.(ng/mL) Determinations No drug present 40 40 negative >99% No drug present 40 40 negative >99% No drug present 60 60 negative >99% 500 40 40 negative >99% 150 40 40 negative >99% 250 30 30 negative >99% 750 40 40 negative >99% 225 40 40 negative >99% 375 15 15 negative >99% 1,000 40 40 positive >99% 375 40 40 positive >99% 625 15 12 positive >80% 1,500 40 40 positive >99% 450 40 40 positive >99% 750 30 30 positive >99% 1000 30 30 positive >99% 2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHEYLPYRROLIDINE (EDDP) COCAINE (COC 150) EDDP Total number of Result Precision METHYLENEDIOXYMETHAMPHETAMINE (MDMA) Benzoylecgonine Total number of Result Precision conc.(ng/mL) Determinations conc.(ng/mL) Determinations Methylenedioxymeth- amphetamine Total number of Result Precision No drug present 60 60 negative >99% Determinations No drug present 60 60 negative >99% conc.(ng/mL) 150 60 60 negative >99% 75 30 30 negative >99% No drug present 40 40 negative >99% 450 60 60 positive >99% 112.5 15 15 negative >99% 250 40 40 negative >99% 600 60 60 positive >99% 187.5 15 11 positive >73% 375 40 40 negative >99% 225 30 29 positive >96% 500 40 40 positive >99% 6-ACETYLMORPHINE (6-ACM) 300 30 30 positive >99% 750 40 40 positive >99% 6-Acetylmorphine Total number of Result Precision conc.(ng/mL) Determinations MARIJUANA (THC 50) No drug present 40 40 negative >99% OPIATE (OPI 300, MOP, MOR) 9-THC-9-COOH Total number of Result Precision 5 40 40 negative >99% conc.(ng/mL) Determinations Morphine Total number of Result Precision 15 40 40 positive >99% conc.(ng/mL) Determinations No drug present 40 40 negative >99% 20 40 40 positive >99% No drug present 40 40 negative >99% 25 40 40 negative >99% 150 40 40 negative >99% 37.5 40 40 negative >99% BUPRENORPHINE (BUP) 225 40 40 negative >99% 50 40 40 positive >99% 300 40 40 positive >99% Buprenorphine Total number of Result Precision 75 40 40 positive >99% 375 40 40 positive >99% conc.(ng/mL) Determinations No drug present 60 60 negative >99% 5 60 60 negative >99% MARIJUANA (THC 20) 15 OPIATE (OPI 2000) 60 60 positive >99% 9-THC-9-COOH Total number of Result Precision 20 60 60 positive >99% conc.(ng/mL) Determinations Morphine Total number of Result Precision conc.(ng/mL) Determinations No drug present 60 60 negative >99% PROPOXYPHENE (PPX) 10 30 29 negative 97% No drug present 40 40 negative >99% 15 15 9 negative 60% 1,000 40 40 negative >99% Propoxyphene Total number of Result Precision conc.(ng/mL) Determinations 25 15 12 positive >80% 1,500 40 40 negative >99% 30 30 29 positive 97% 2,000 40 40 positive >99% No drug present 60 60 negative >99% 40 30 30 positive >99% 3,000 40 40 positive >99% 150 60 60 negative >99% 450 60 60 positive >99% 600 60 60 positive >99% METHADONE (MTD) OXYCODONE (OXY) Methadone Total number of Result Precision Oxycodone Total number of Result Precision KETAMINE (KET) conc.(ng/mL) Determinations conc.(ng/mL) Determinations

PN: Ketamine Total number of Result Precision conc.(ng/mL) Determinations No drug present 40 40 negative >99% No drug present 40 40 negative >99% Y03 111 17405 150 40 40 negative >99% 50 40 40 negative >99% No drug present 24 24 negative >99% 225 40 40 negative >99% 75 40 40 negative >99% 500 24 24 negative >99% 300 40 40 positive >99% 100 40 40 positive >99% 1,000 24 24 positive >99% 450 40 40 positive >99% 150 40 40 positive >99% 1,500 24 24 positive >99% COTININE（COT） Analytical Sensitivity Drug concentration n KET Cotinine Total number of Result Precision Cut-off Range - + conc.(ng/mL) Determinations A drug-free urine pool was spiked with drugs at concentrations listed. The results are summarized 0% Cut-off 30 30 0 below. No drug present 60 60 negative >99% -50% Cut-off 30 30 0 100 60 60 negative >99% Cut-off 30 0 30 +50% Cut-off 30 0 30 400 60 60 positive >99% Drug concentration n AMP 1000 BAR BZO COC 300 THC 50 Cut-off Range - + - + - + - + - + 0% Cut-off 10 10 0 10 0 10 0 10 0 10 0 Analytical Specificity SYNTHETIC CANNABINOID (K2 50) -50% Cut-off 10 10 0 10 0 10 0 10 0 10 0 The following table lists the concentration of compounds (ng/mL) that were detected positive in JWH-018 Pentanoic Acid/ Total number of Result Precision JWH-073 Butanoic Acid -25% Cut-off 10 10 0 10 0 10 0 10 0 10 0 urine by the at a read time of 5 minutes. conc.(ng/mL) Determinations ECO CUP™ One Step Drug Test Cut-off 10 0 10 0 10 0 10 0 10 0 10 No drug present 60 60 negative >99% 25 60 60 negative >99% +25% Cut-off 10 0 10 0 10 0 10 0 10 0 10 Drug Concentration (ng/mL) 75 60 60 positive >99% +50% Cut-off 10 0 10 0 10 0 10 0 10 0 10 AMPHETAMINE (AMP 1000) d-amphetamine 1,000 D,l-amphetamine 1,000 Drug concentration MTD mA MP1000 MDMA MOR OPI OXY PCP TCA SYNTHETIC CANNABINOID (K2 20) n l-amphetamine 20,000 Cut-off Range - + - + - + - + - + - + - + - + JWH-018 Pentanoic Acid/ Total number of Phentermine 1,250 JWH-073 Butanoic Acid Result Precision 0% Cut-off 10 0 10 0 conc.(ng/mL) Determinations 10 10 0 10 0 10 0 10 0 10 0 10 0 (+/-)-Methylenedioxyamphetamine 1,500 No drug present 60 60 negative >99% -50% Cut-off 10 10 0 10 0 10 0 10 0 10 0 10 0 10 0 10 0 10 60 60 negative >99% -25% Cut-off 10 10 0 10 0 10 0 10 0 10 0 10 0 10 0 10 0 AMPHETAMINE (AMP 500) 30 60 60 positive >99% Cut-off 10 0 10 0 10 0 10 0 10 0 10 0 10 0 10 0 10 d-amphetamine 500 +25% Cut-off 10 0 10 0 10 0 10 0 10 0 10 0 10 0 10 0 10 D,l-amphetamine 750 l-amphetamine 16, +50% Cut-off 10 0 10 0 10 0 10 0 10 0 10 0 10 0 10 0 10 FENTANYL (FEN) Phentermine 650 (+/-)- Methylenedioxyamphetamine 800 Fentanyl Total number of Result Precision conc.(ng/mL) Determinations Drug concentration n AMP 300 COC 150 THC 20 mAMP 500 Cut-off Range - + - + - + - + AMPHETAMINE (AMP 300) No drug present 60 60 negative >99% 0% Cut-off 25 25 0 25 0 25 0 25 0 d-amphetamine 300 60 negative D,l-amphetamine 500 100 60 >99% -50% Cut-off 25 25 0 25 0 25 0 25 0 l-amphetamine 10,000 300 60 60 positive >99% -25% Cut-off 25 25 0 25 0 25 0 25 0 Phentermine 400 Cut-off 25 1 24 3 22 2 23 2 23 (+/-)-Methylenedioxyamphetamine 500 +25% Cut-off 25 0 25 0 25 0 25 0 25 TRAMADOL（TRA） +50% Cut-off 25 0 25 0 25 0 25 0 25 BARBITURATES (BAR) Tramadol Total number of Result Precision Secobarbital 300 conc.(ng/mL) Determinations Amobarbital 300 Drug concentration BUP PPX EDDP 6-ACM AMP500 COT ETG Alphenol 150 N o drug present 60 60 negative >99% n n Cut-off Range 25 60 60 negative >99% - + - + - + - + - + - + - + Aprobarbital 200 75 60 60 positive >99% 0% Cut-off 90 90 0 90 0 90 0 90 0 90 0 90 0 30 30 0 Butabarbital 75 -50% Cut-off 90 90 0 90 0 90 0 90 0 90 0 90 0 30 30 0 Butalbital 2,500 -25% Cut-off 90 81 9 81 9 78 12 80 10 81 9 90 0 30 30 0 Butethal 100 Cyclopentobarbital 600 METHYLENEDIOXYPYROVALERONE (MDPV) Cut-off 90 48 42 44 46 41 49 46 44 45 45 63 27 30 3 27 Pentobarbital 300 Methylenedioxypyrovalerone +25% Cut-off 90 11 79 12 78 15 75 12 78 10 80 40 50 30 1 29 Phenobarbital 100 +50% Cut-off 90 0 90 0 90 0 90 0 90 0 90 16 74 30 0 30 2X Cut-off 90 0 90 0 90 0 90 0 90 0 90 0 90 30 0 30 BENZODIAZEPINES (BZO) a-Hydroxyalprazolam 1,260 Alprazolam 200 Drug concentration K 2 5 0 K 2 2 0 F E N T R A M D P V n n Bromazepam 1,560 Cut-off Range - + - + - + - + - + Chlordiazepoxide 1,565 0% Cut-off 10 10 0 10 0 30 30 0 30 0 30 0 Chlordiazepoxide HCl 780 ETHYL GLUCURONIDE (ETG) Clobazam 100 -50% Cut-off 10 10 0 10 0 30 30 0 30 0 30 0 Clonazepam 785 Ethyl Glucuronide Total number of Result Precision -25% Cut-off conc. (ng/mL) Determinations 10 10 0 10 0 30 30 0 30 0 30 0 Clorazepate Dipotassium 195 Delorazepam 1,560 No drug present 70 70 negative >99% Cut-off 10 0 10 0 10 30 2 28 2 28 2 28 Desalkylflurazepam 390 150 70 70 negative >99% Diazepam 195 +25% Cut-off 10 0 10 0 10 30 0 30 0 30 0 30 450 70 70 positive >99% Estazolam 2,500 +50% Cut-off Flunitrazepam 385 600 70 70 positive >99% 10 0 10 0 10 30 0 30 0 30 0 30 (±) Lorazepam 1,560 0 0 0 0 0 0 0 0 0 0 0 2 2 0 40 10 50 24 10 0 0 0 400 2 0 300 100 400 200 100 , , , , 1,000 0 0 0 2,500 8,000 2,500 0 3,500 1,500 6,250 30,000 4 70,000 50,000 4 2 10,000 20,000 40,000 40,000 45,000 50,000 50,000 50,000 50,000 5 70,000 50,000 50,000 10,000 12,500 15,000 25,000 25,000 100,000 100,000 100,000 100,000 100,000 100,000

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4 5 5 5 h h

4 3 5 4 6 5 1 N-( N-4-

m p p 3 8 2 0 - IDENE y a ime 7 1 eraz 2 eraz r 2 N-( m x h 0 0 1 t 210 122 018 073 019 073 019 018 T 2 a o - - - e AMINE (KET) h h M H H H t t m ifluop ifluop A e e - r r ,4,6- enlafaxine hydrochloride W W W ramadol WH- WH- WH- WH- WH- WH- WH- WH- T Methadone Meperidine M JWH-398 N-pentanoic acid metabolite J J SYNTHETIC CANNABINOID (K2) J J J J D Promethazine Phencyclidine M 2 M KET Ketamine J J J Bupivacaine Disopyramide Eserine J J RCS-4 T L 2-ETHY EDDP Phencyclidine Disopyramide Mianserin T V Nalorphine Hydromorphone Levorphanol Normorphine Norcodeine Oxycodone Oxymorphone Thebaine COTININE (COT) (-)-Cotinine (-)-Nicotine 6-ACETYLMORPHINE 6-Acetylmorphine Morphine Bilirubin Codeine Diacetylmorphine Ethylmorphine Hydrocodone 75 25 90 500 300 500 100 100 500 300 800 400 100 625 300 200 400 3,000 2,000 1,250 1,000 2,000 5,000 2,000 1,000 1,580 1,580 1,000 1,500 2,000 2,000 1,000 1,500 2,500 3,000 300 15,000 75,000 13,000 10,000 50,000 26,000 50,000 12,500 25,000 12,500 50,000 12,500 AMINE (MDMA) (MDMA) AMINE , MOR) ANTIDEPRESSANTS (TCA) P TE (OPI 300, MO TE (OPI 2000) Morpholine rimipramine Promazine Promethazine T T METHYLENEDIOXYMETHAMPHE Methylenedioxymethamphetamine 3,4-Methylenedioxyamphetamine (+/-)-3,4-Methylenedioxy-n-ethylamphetamine OPIA 6-acetylmorphine Codeine Eserine (Physostigmine) Ethylmorphine Heroin Hydromorphone Hydrocodone Morphine Morphine-3-glucuronide Oxycodone Thebaine OPIA 6-acetylmorphine Codeine Ethylmorphine Heroin Hydromorphone Hydrocodone Morphine Morphine-3-glucuronide Oxycodone Thebaine OXYCODONE (OXY) Oxycodone Codeine Dihydrocodeine Ethylmorphine Hydrocodone Hydromorphone Oxymorphone Thebaine PHENCYCLIDINE (PCP) Phencyclidine 4-Hydroxy PCP PCP PROPOXYPHENE (PPX) Norpropoxyphene Propoxyphene TRICYCLIC Nortriptyline Amitriptyline Clomipramine Desipramine Doxepin Imipramine Maprotiline Nordoxepin 20 50 50 50 10 20 95 500 300 300 300 150 300 200 390 300 100 160 1000 1,000 2,500 1,000 1,000 5,000 2,500 2,500 2,500 90,000 10,000 50,000 20,000 60,000 20,000 50,000 20,000 20,000 15,000 10,000 10,000 80,000 75,000 12,500 500,000 200,000 2,500 1000) 500) (mAMP AMINE etrahydrocannabinol AMINE (mAMP -T 9 (THC 50) (THC 20) etrahydrocannabinol-9 Carboxylic Glucuronide -T -THC-9-COOH -THC-9-COOH -THC-9-COOH -THC-9-COOH 8 9 9 8 9 -THC -THC -THC -THC 8 9 8 9 rimethobenzamide riazolam emazepam (+/-)-3,4-Methylenedioxy-n-ethylamphetamine Procaine (Novocaine) T +/-methamphetamine +methamphetamine Ranitidine (Zantac) Methylenedioxymethamphetamine METHAMPHET d-methamphetamine D,l-Methamphetamine lRanitidine Procaine (+/-)-Methylenedioxyamphetamine Methylenedioxymethamphetamine (+/-)-3,4-Methylenedioxy-n-ethylamphetamine Cannabinol METHAMPHET BUPRENORPHINE (BUP) BUPRENORPHINE Buprenorphine Norbuprenorphine COCAINE (COC 300) Benzoylecgonine Cocaethylene Cocaine Metoclopramide Procaine COCAINE (COC 150) Benzoylecgonine Cocaethylene Cocaine MARIJUANA RS-Lorazepam glucuronide RS-Lorazepam Midazolam Nitrazepam Norchlordiazepoxide Nordiazepam Oxazepam T T METHADONE (MTD) Methadone Doxylamine MARIJUANA

PN: Y0311117405 Glutathione reduced 50,000 Acebutolol Cefoxitin Ecgonine Methyl Ester Lysergic Acid Diethylamide p-Phenylenediamine Trimipramine Acetaldehyde Ceftriaxone Emetine (LSD) Phenelzine Triprolidine Mianserin 30,000 Acetaminophen Cefuroxime Ephedrine Mebendazole Phenformin Tropic Acid Naphazoline hydrochloride 20,000 Acetamidophenol Cephalexin Epinephrine Meclizine Pheniramine Tropine Nomifensine 100,000 (N-Acetyl-p-aminophenol ) Cephaloridine Erythromycin Meclofenamic Acid Phenol Tryptamine Prilocaine 50,000 Acetazolamide Cephradine Estradial Medazepam Phenolphthalien Tyramine Promazine 100,000 Acetone Chloramphenicol Estriol Mefenamic Acid Phenothiazine Urea ( Carbamide ) Acetophenetidin Chlorcyclizine Estron Melanin Phenoxymethyl Uric Acid Pyrilamine 50,000 Acetopromazine Chloroquine Glucuronide Melphalan Penicillinic acid ( Penicillin V ) Vancomycin Thioridazine hydrochloride 100,000 N-Acetyl-L-cysteine Chlorothiazide Estrone-3-Sulfate Menthol Phentolamine Vincamine Benzthiazide 100,000 N-Acetylprocainamide Chlorotrianisene Ethacrynic Acid Meperidine Phenylbutazone Xylometazoline Picrotoxin 10,000 (Acedainide ) Chlorpheniramine Ethambutol Mephenesin Phenylethylamine Yohimbine Acetylsalicylic Acid (Aspirin) Chlorpromazine Ethamivan Mephentermine Phenylpropanolamine Zearalenone Phenyltoloxamine 100,000 Albumin, standard Chlorpropamide Ethanol, Standard Meprobamate Pilocarpine Zomepirac 2,4,6-Trimethylbenzamide 100,000 Allobarbital (Diallybarbituric Chlorprothixene Ethopropazine Metaproterenol Pimozide Zopiclone Acid ) Chlorthalidone Ethosuximide Phenylnalonamide Metaraminol Pinacidil FENTANYL (FEN) Allopurinol Chlorzoxazone Ethylene Glycol Methadone Pindolol Fentanyl 200 (4-Hydroxypyrazole)(3,4- Cholesterol Ethylenediamine Tetraacetic Acid Methanol, Absolute Pipecolic Acid Methadone Non pyrimidine) Cimetidine Etodolac Methaqualone Pipedemic Acid Cross-Reacting Compounds Alprenolol Cinchonidine Etoposide Methazolamide Piroxicam *Parent compound only： TRAMADOL (TRA) Amantadine Cinoxacin Famotidine Methotrimeprazine Potassium Chloride Tramadol 50 (Adamantan-1-amine) Clemastine Fenfluramine Methoxamine Potassium Iodide Amcinonide Clenbuterol Fenoprofen Naphthalene Acetic Acid Prazepam Prazosin METHYLENEDIOXYPYROVALERONE (MDPV) Amikacin Clindamycin Fentanyl Naproxen Acebutolol Amiloride Clobetasone Butyrate Ferrous Sulfate Methoxyamine Prednisone Methylenedioxypyrovalerone 1,000 Acetaldehyde p-Aminobenzoic Acid Clomipramine Flufenamic Acid Hydroxyprogesterone Primaquine Acetaminophen Acetazolamide Butylone 1,000 DL-Aminoglutethimide Clonidine Flunisolide Methylene Blue Primidone Acetone Ethylone 1,000 Amiodarone Cloxacillin Fluphenazine Methylphenidate (Ritalin ) Proadifen Acetophenetidin Methylone 10,000 Amitryptyline Clozapine Flurandrenolide Methyl Salicylate Probenecid N-Acetylprocainamide Ammonium Chloride Colchicine Flurazepam Meticrane Procainamide Mephedrone 10,000 (Acedainide ) Amoxicillin Cortisone Flurbiprofen Metronidazole Prochlorperazine Acetylsalicylic Acid ( Aspirin) Methedrone 10,000 Amphotericin B Cortol Formaldehyde Milrinone Procyclidine Aminopyrine Pyrovalerone 4,000 Ampicillin Creatinine Furosemide Minaprine Promazine Amitryptyline Naphyrone ＞100,000 Aniline Cromolyn Gemfibrozil Nabumetone Propionylpromazine Ammonium Chloride Flephedrone ＞100,000 Antipyrine Cyclobenzaprine Gentamicin Sulfate Nadolol Protriptyline Amobarbital Brompheniramine ＞100,000 Apomorphine Cyclophosphamide Gentisic Acid Nafcillin Pseudoephedrine Amoxicillin L-Ascorbic Acid Cyclosporin A Glucose Nalbuphine Pyridine-2-Aldoxime Methyprylon ＞100,000 Amphotericin B ASP-PHE-Methyl-Ester Cyproheptadine Glybenclamide Nalidixic Acid Pyridoxine Ampicillin Zomepirac ＞100,000 (Aspartame) Dantrolene Griseofulvin Nalmefene Quinidine Aniline D-Aspartic Acid Deferoxamine Mesylate Guaiacol Glyceryl Ether Nalorphine Quinine Antipyrine ETHYL GLUCURONIDE (ETG) DL-Aspartic Acid Delta-8-THC Guanethidine Naloxone Quinolinic Acid DL-Amphetamine sulfate L-Aspartic Acid (-)-delta-9-THC Halcinonide Naltrexone Ranitidine 300 DL-Aspartic Acid Baclofen Deoxyepinephrine Haloperidol Naphthalene Acetic Acid Rescinnamine L-Aspartic Acid Barbituric Acid Desipramine Hemoglobin Naphthol Reserpine Apomorphine The following substances may interfere with the alcohol test: strong oxidizers, ascorbic acid, tannic Beclomethasone Desmethyldiazepam Hexachlorocyclohexane Neomycin Sulfate Riboflavin Aprobarbital acid, polyphenolic compounds, mercaptans, uric acid, bilirubin, oxalic acid and so on, but these Beclomethasone Dipropionate Desoximetasone Hexachlorophene Niacinamide Ritodrine Aspartame compounds are not normally present in sufficient amount in urine to interfere with the test. Bendroflumethiazide Dexamethasone Hexobarbital Nialamide Salbutamol (Albuterol ) Atropine Benzidine Dextromethorphan Hippuric Acid (+/-) Nicotine Salicylic Acid Barbituric Acid EFFECT OF URINARY SPECIFIC GRAVITY Benzilic Acid diethylaminoethyl Diazoxide Histamine Nicotinic Acid Sodium Chloride Benzidine Fifteen (15) urine samples of normal, high, and low specific gravity ranges (1.005, 1.015, 1.03) were ester Dichloromethane DL-Homatropine Nifedipine Sodium Formate Benzilic Acid Benzocaine spiked with drugs at 50% below and 50% above cut-off levels respectively. The ECO CUP™ Benzocaine Dichlorphenamide Hydrastine Nitrofurantoin Sulfamethazine Benzoic Acid One Step Drug Test was tested in duplicate using ten drug-free urine and spiked urine samples. Benzoic Acid Diclofenac Hydrochlorothiazide Norclomipramine Sulfamethoxazole Benzoylecgonine The results demonstrate that varying ranges of urinary specific gravity do not affect the test results. Benzphetamine Dicyclomine Hydrocortisone Norcocaine Sulfanilamide Benzphetamine Benzthiazide Dieldrin Hydrocarbalamine Norcodeine Sulfathiazole Benzthiazide EFFECT OF THE URINARY PH Benztropine Diflorasone Diacetate Hydroflumethiazide Nordoxepin Sulfisoxazole Bilirubin Benzyl alcohol Diflucortolone pivalate Hydroxyhippuric Acid Norethindrone Sulindac Bisacodyl The pH of an aliquoted negative urine pool was adjusted to pH ranges of 4.0, 4.5, 5.0, 6.0 and Benzylamine Diflunisal Hydroxyzine Norfloxacin Talbutal 9.0, and spiked with drugs at 50% below and 50% above cut-off levels. The spiked, pH-adjusted Bromazepam Berberine Digitoxin Ibuprofen Normorphine Tannic Acid 2-Bromo-a -ergocryptine urine was tested with the ECO CUP™ One Step Drug Test. The results demonstrate that Betamethasone Digoxin Indapamide Noscapine Terbutaline varying ranges of pH do not interfere with the performance of the test. Brompheniramine Bilirubin Dihydroxymandelic Acid Indomethacin Nylidrin Terfenadine Caffeine Tetracycline INTERFERENCE Brompheniramine Theophylline Ipratropium Bromide Orphenadrine Cannabidiol Bumetanide Dimenhydrinate Iproniazid Oxalic Acid Theobromine Cannabino A study was conducted to determine the cross-reactivity of the test with compounds in either Buspirone Dimercaprol Isonicotinic Acid Oxolinic Acid Theophylline Chloramphenicol drug-free urine or drug positive urine containing Cocaine, Barbiturates, Benzodiazepines, Butacaine Dimethylaminoantipyrin Isopropamide Oxprenolol Thiamine Chlorcyclizine Amphetamine, Methamphetamine, Marijuana, Methadone, Methylenedioxymethamphetamine, Butyrophenone Dimethyl Isosorbide Isoxsuprine Oxymetazoline Tobramycin Chlordiazepoxide Opiate, Oxycodone, Phencyclidine, Morphine, EDDP (Methadone Metabolites), 6-Acetylmorphine, Caffeine Dimethyl Sulfoxide Kanamycin Oxyphenbutazone Tolazamide Chloroquine Buprenorphine, Propoxyphene，Tricyclic Antidepressants，Cotinine，Synthetic Cannabinoid, Camphor Diphenhydramine Ketoprofen Oxypurinol Tolbutamide Chlorothiazide Ketamine, Fentanyl, Tramadol, Methylenedioxypyrovalerone or Ethyl Glucuronide. The following Canrenoic Acid Dipyridamole Kynurenic Acid Paclitaxel Tolmetin Chlorotrianisene compounds show no cross-reactivity when tested with the ECO CUP™ One Step Drug Test Captopril Dipyrone Labetalol Pancuronium Bromide Toluene Chlorpheniramine at concentrations of 100µg/mL. Carbamazepine Dobutamine Levorphanol Papaverine Trazodone Chlorpromazine Carbamyl-Carboplatin Doxepin Lidocaine Pargyline Triamcinolone Dimercaprol Cocaine, Benzodiazepines, Amphetamine, Methamphetamine, Marijuana, Opiate, Morphine, Carisoprodol Doxycycline Lisinopril Penicillin Triamterene Dimethylaminoantipyrin Oxycodone, Phencyclidine, Barbiturates, Buprenorphine, Propoxyphene, Ketamine, EDDP, Cefaclor Doxylamine Lithium Carbonate Pentachlorophenoll Trichlormethiazide Dimethyl Isosorbide 6-Acetylmorphine. Non Cross-Reacting Compounds Cefadroxil Droperidol Loperamide Pentoxifylline Trichloroacetic acid Dimethyl Sulfoxide ： *Parent compound only Cefotaxime Ecgonine Lormetazepam Pentylenetetrazole Trimethoprim Disopyramide Acid d6 － Acid1

= 3,4- 1-nor-9-carboxy-delta-9-THC Acid ryptophan yrosine 1-nor-9-carboxy-delta-9-THC ramadol razodone rifluoperazine rimethoprim ryptamine yramine emazepam etracycline etrahydrocortisone etrahydrozoline 1-Hydroxy-delta-9-THC *Parent compound only: 1 1-Naphthylacetic 2,3-Pyridine Dicarboxylic (+/-)-1 (+/-)-4-Hydroxyamphetamine HCL Hydrate MethylenedioxymethamphetamineZ Synthetic Cannabinoid Non Cross-Reacting Compounds (-)-1 (-)-delta-9-THC (+/-) Nicotine 4-Metylumbelliferyl B-D-Glucuronide 5,5-Diphenylhydantoin Acebutolol Acetaminophen Acetazolamide Acetone Acetophenetidin Acetopromazine (±)Phenylpropanolamine Prednisolone Procaine Promazine Promethazine Propranolol d-Propoxyphene Pseudoephedrine Quinacrine Quinidine Quinine Ranitidine Riboflavin Salicylic acid Secobarbital Serotonin Sodium Chloride Sulfamethazine Sulindac T T T T Thebaine Theophylline Thiamine Thioridazine l-Thyroxine T T T T T d,l-T T d,l-T Uric Zomepirac *MDA=3,4- Methylenedioxyamphetamine **MDMA Phencyclidine Phenelzine Pheniramine Phenobarbital Phenothiazine Phentermine 3-Hydroxytyramine Lidocaine Acid Ethanol Ethyl-p-aminobenzoate Etodolac Fenfluramine Fenoprofen Furosemide Gentisic acid d (+) Glucose Hydralazine Hydrochlorothiazide Hydrocodone Hydrocortisone Hydromorphone HCL (+/-)-4-Hydroxyamphetamine o-Hydroxyhippuric acid p-Hydroxymethamphetamine Hydroxyzine Ibuprofen Imipramine Imidazole (-)Isoproterenol Isoxsuprine Ketamine Labetalol l-Ascorbic acid l-Epinephrine Levorphanol Lisinopril Loperamide Maprotiline Meperidine Mefenamic Dipyrone Digoxin 4-Dimethylaminoantipyrine Diflunisal 5,5-Diphenylhydantoin Disopyramide Doxylamine Ecgonine Methylester EDDP Ephedrine Erythromycin Meprobamate Methadone d-Methamphetamine l-Methamphetamine Methoxyphenamine MDA* MDMA** Methylphenidate Morphine Sulfate Nalorphine Naloxone Naltrexone Nimesulide Norethindrone d-Norpropoxyphene Noscapine d,l-Octopamine Orphenadrine Oxalic acid Oxazepam Oxypurinol Oxycodone Oxymetazoline Oxymorphone Papaverine Paracetamol Penicillin-G Pentobarbital Perphenazine Phenylephrine-L Amoxicillin iagra) Acid Acid Acid Acid Alcohol Acid feine erapamil alproic razodone rimethoprim ryptophan yrosine emazepam etracycline etrahydrocortisone obutamide Benzoic Benzoylecogonine Benzyl Bilirubin Brompheniramine Buspirone Caf Cannabidiol Captopril Chloral Hydrate Chloramphenicol Chlordiazepoxide Chloroquine (+)-Chlorpheniramine (±)Chlorpheniramine Chlorpromazine Chlorprothixene Cholestrol Cimetidine Clomipramine Clonidine Cocaine Codeine Cortisone Creatinine Cyclobarbital Cyclobenzaprine Deoxycorticosterone Delorazepam Desoximetasone Dextromethorphan Diazepam Cotinine Non Cross-Reacting Compounds *Parent compound only Acetone Acetophenetidin Albumin Amitryptyline Amobarbital L-amphetamine Ampicillin Apomorphine Aspartame Atropine Benzilic Quinidine Ranitidine Riboflavin Salicylic V Sidenafil( Chloride Sodium Sulfamethoxazole Sulindac T T T Theophyline Thiamine Thioridazine Thyroxine T T T T T Urea Uric V V Zoloft Acid feine Buspirone Caf Captopril Carbamazepine Cefaclor Cemetidine Chloramphenicol Chlordiazepoxide Chloroquine Chlorothiazide Chlorpheniramine Chlorpromazine Chlorpropamide Cholesterol Clindamycin Clonidine Clozapine Colchicine Cortisone Creatinine Deoxycorticosterone Desipramine Dextromethorphan Diazepam Digoxin Diphenhydramine Dipyridamole Doxycycline Erythromycin Estradiol Estriol Estrone Ethanol Ethylene Glycol Epinepherine Ferrous Sulfate Furosemide Gentamycin Glucose Haloperidol Hemoglobin Hydralazine Hydrocortisone Hydroxycarbalamine Hydroxyprogesterone Hydroxyzine Ibuprofen Indomethacin Lidocaine Lisinopril Lithium Loperamide Lorazepam LSD Metronidazole Naproxen Niacinamide Nicotine Nifedipine Nitrofurantoin Nortriptyline Ofloxacin Oxalic Penicillin G Pentobarbital Phenobarbital Prednisolone Prednisone Prochloperazine Promethazine Propoxyphen Propranolol Prozac(Fluoxetin) Pseudoephedrine Pyroxidine

: Acid Acid ryptophan yrosine Phenylethlamine erapamil riamterene rifluoperazine rimethoprim rans-2-Phenyl-cylopropylamine-hydr yramine emazepam etracycline etrahydrocortisone, 3 etrahydrocortisone 3 etrahydrozoline olbutamine Secobarbital Serotonin (5-Hydroxytyramine) Sulfamethazine Sulindac T T T Acetate T (ß-D-glucuronide) T Thiamine Thioridazine T T T T D, L-T T D, L-T Uric acid V Zomepirac Acetaldehyde Acetaminophen Acetazolamide Acetone Albumin Albuterol Ammonium Amphotericin B Ampicillin Amtriptyline Apomorphine Ascorbic Phenylpropanolamine Prednisolone Prednisone Procaine Promethazine D,L-Propanolol D-Propoxyphene D-Pseudoephedrine Quinidine Quinine Ranitidine Salicylic acid Non Cross-Reacting Compounds *Parent compound only Methylenedioxymethamphetamine ß- Penicillin-G Pentazocine Pentobarbital Perphenazine Phencyclidine Phenelzine Phenobarbital Phentermine T ochloride Aspartate Aspirin Atenolol Atropine Beclomethasone Benzocaine Benzoic Bilirubin Bupropion Ephedrine Y ¬-Estradiol Chlorquine Cholesterol Clonidine hydrochloride Cocaine Codeine Cortisone (-) Cotinine Creatinine Deoxycorticosterone Dextromethorphan Diazepam Diclofenac Diflunisal Digoxin Diphenhydramine Doxylamine Ecgonine hydrochloride Ecgonine methylester (IR,2S)-(-)-Ephedrine L-Ephedrine (-) Erythromycin ß Estrone-3-sulfate Ethyl-p-aminobenzoate Fenoprofen Furosemide Gentisic Hemoglobin Hydralazine Hydrochlorothiazide Hydrocodone Hydrocortisone p-Hydroxyamphetamine O-Hydroxyhippuric p-Hydroxy-methamphetamine 3-Hydroxytyramine Ibuprofen Iproniazid (-) Isoproterenol Isoxsuprine Ketamine Ketoprofen Labetalol Levorphanol Loperamide Meperidine Meprobamate Methadone D-methamphetamine Methoxyphenamine 3,4-Methylene-dioxyethylamph etamine (+)3,4-Methylene-dioxymetha mphetamine Methylphenidate Morphine-3-D-glucuronide Morphine sulfate Nalidixic acid Naloxone Naltrexone Naproxen Niacinamide Nifedipine Norcodein Norethindrone D-Norpropoxyphene Noscapine D,L-Octopamine Oxalic acid Oxazepam Oxolinic acid Oxycodone Oxymetazoline Papaverine : Antidepressants Non Acid Acid feine incamine ricyclic ancomycin ohimbine razodone riamcinolone riamterene riazolam richlormethiazide richloroacetic acid rifluoperazine riflupromazine rimethobenzamide rimethoprim rimipramine riprolidine ropic ropine ryptamine yramine etrahydrozoline obramycin olazamide olbutamide olmetin oluene erfenadine etracycline etraethylthiuram T Theobromine Theophylline Thiamine Thioridazine T T T T T T T T T T T T T T T T T T T T T Urea ( Carbamide ) Uric V V Xylometazoline Y Zearalenone Zomepirac Zopiclone 4-Acetamidophenol Acetophenetidin N-Acetylprocainamide Acetylsalicylic acid Aminopyrine Amobarbital Amoxicillin DL-Amphetamine Ampicillin Ascorbic acid Apomorphine Aspartame Atropine Benzilic acid Benzoic acid Benzoylecgonine Benzphetamine Bilirubin Brompheniramine Caf Cannabidiol Cannabinol Chloralhydrate Chloramphenicol Chlordiazepoxide Chlorothiazide (±) Chlorpheniramine Chlorpromazine T T T T Cross-Reacting Compounds *Parent compound only Acid Acid Acid Acid Acid albutal amoxifen annic enoxicam erbutaline Secobarbital Sodium Chloride Sodium Formate Sulfamethazine Sulfamethoxazole Sulfanilamide Sulfathiazole Sulfisoxazole Sulindac T T T T T Pipedemic Piroxicam Potassium Chloride Potassium Iodide Prazepam Prazosin Prednisone Prilocaine Primaquine Primidone Proadifen Probenecid Procainamide Prochlorperazine Procyclidine Promazine Promethazine Propionylpromazine Protriptyline Pseudoephedrine Pyridine-2-Aldoxime Pyridoxine Pyrilamine Quinidine Quinine Quinolinic Oxazepam Ranitidine Rescinnamine Reserpine Riboflavin Ritodrine Salbutamol (Albuterol ) Salicylic Pargyline Penicillin Pentachlorophenol Pentobarbital Pentoxifylline Pentylenetetrazole p-Phenylenediamine Phenelzine Phenformin Pheniramine Phenobarbital Phenol Phenolphthalien Phenothiazine Phenoxymethyl ) Penicillinic acid ( Penicillin V Phentolamine Phenylbutazone Phenylethylamine Phenylpropanolamine Phenyltoloxamine Picrotoxin Pilocarpine Pimozide Pinacidil Pindolol Pipecolic Acid Acid Acid Acid Acid Acid Acid Labetalol Levorphanol Loperamide Meperidine Mephentermine Methoxyphenamine Hydroxyprogesterone Nifedipine Nitrazepam Noscapine Oxycodone Oxymetazoline Oxyphenbutazone Oxypurinol Glucose Hemoglobin Hydralazine Hydrastine Hydrochlorothiazide Hydrocodone Hydrocortisone Hydrocarbalamine Hydroflumethiazide Hydroxyhippuric Dobutamine Doxepin Doxycycline Ecgonine Methyl Ester Ecgonine Emetine Ephedrine Epinephrine Erythromycin Estriol Estrone Ethyl-p-aminobenzoate Etodolac Etoposide Famotidine Fenfluramine Ferrous Sulfate Flufenamic Flunisolide Formaldehyde Furosemide Gemfibrozil Gentamicin Sulfate Gentisic p-Hydroxyamphetamine Hydroxyzine Ibuprofen Imipramine Indapamide Indomethacin Ipratropium Bromide Iproniazid Isonicotinic Isopropamide Isoxsuprine Kanamycin Ketamine Ketoprofen Kynurenic Methylphenidate (Ritalin ) Methyl Salicylate Nabumetone Nadolol Nafcillin Nalidixic Nalmefene (+/-) Nicotine Nicotinic Paclitaxel Pancuronium Bromide Papaverine

PN: Y0311117405 Acetyl-L-Cysteine Cefadroxil Dipyrone Hypnoval（Cyclobarbital） Naphazoline Hydrochloride Potassium Iodide Trazodone Baclofen Acetylsalicylic Acid (Aspirin) Cefotaxime Disopyramide Hypoxanthine Naphthol p-Phenylene Triazolam Benzphetamine a-Chymotrypsin Cefoxitin DL-3,4-Dihydroxymandelic Acid Ibuprofen Naproxen Prazepam Trichlormethiazide Barbituric Acid a-Hydroxyalprazolam Cefradine Capsules DL-Aminoglutethimide Imidazole Neomycin Sulfate Prazosin Trichloroacetic Acid Berberine a-Hydroxyhippuric Acid Ceftriaxone DL-Aspartic Acid Imipramine Niacinamide Prednisolone Acetate Trimethoprim Benzocaine Albumin, Human RecombinantCefuroxime Axetil (Zinnat) DL-Tryptophan Indapamide Nialamide Prednisone Trimipramine Benzyl alcohol Allopurinol Cephradine D-Methamphetamine Indomethacin Nicotinic Acid Prilocaine Triprolidine Benzoylecogonine Alphenal Cetirizine Hydrochloride Dobutamine Ipratropium Bromide Nifedipine Primaquine diphosphate Tropic Acid Bendroflumethiazide Alprazolam Chloral Hydrate Dopamine Isonicotinic Acid Nimesulide Primidone Tropine Benzylamine Hydrochloride Alprenolol Hydrochloride Chloramphenicol Doxepin Isoproterenol-(+/-) Nitrazepam Proadifen Tryptamine Bisacodyl Amantadine Hydrochloride Chlordiazepoxide HCL Doxycycline Hytclate Isoxsuprine Nitrofurantoin Probenecid Tyramine Bromazepam Amikacin Chloroquine Doxylamine JWH-210 4-hydroxypentyl Nomifensine Procainamide Hydrochloride Urea Bupivacaine Amikacin Sulfate Chlorothiazide Droperidol metabolite Norchlordiazepoxide Procaine Uric Acid Buprenorphine Amiloride Chlorotrianisene Ecgonine Methylester Ketamine Norclomipramine Prochlorperazine Dimaleate Salt Vancomycin HCL Buspirone Aminophenazon Chlorpheniramine Emetine Dihydro-Chloride Kynurenic Acid Norcocaine Procyclidine Vanillic acid Diethylamine Butacaine Aminophylline Chlorpromazine Hydrate Labetalol Nordiazepam Promazine VB2 Butabarbital Amiodarone Hydrochloride Chlorpropamide Ephedrine-(+/-) Lactose Nordoxepin Promethazine Venlafaxine Hydrochloride Amitriptyline Chlorprothixene Erythromycin L-Aspartic Acid Norethindrone Propionylpromazine Verapamil Butyrophenone Ammonium Chloride Chlorthalidone Eserine L-Cystine Norfloxacin Propoxyphene,d- Vincamine Butethal Amobarbital Chlorzoxazone Estazolam Levorphanol Norfludiazepam Propranolol Xylometazoline Caffeine Amoxicillin Cholesterol Estradiol,17B- Lidocaine Norpropoxyphene Protriptyline Yohimbine Carbamazepine Amphetamine Sulfate Cicosporin Estriol Lisinopril Nortriptyline Hydrochloride Pseudoephedrine HCL Zearalenone Carisoprodol Amphotericin B Cimetidine Estrone Lithium Carbonate Noscapine Pyridine-2-Aldoxime Zomepirac Cefaclor Ampicinine(Ampicillin) Cinchonidine Estrone-3-Sulfate Loperamide Nylidrin Pyridoxine Zopiclone Ceftriaxone Anamycin Sulfate Cinoxacin Ethacrynic Acid Lorazepam (±) /Lorazepam O6-Acetylmorphine Pyrilamine Cefotaxime Cefoxitin Aniline Citric Acid Ethambutol Glucuronide Octopamine Quinacrine Cefuroxime Axetil (Zinnat) Antipyrine Clenbuterol Hydrochloride Ethyl Acetate L-Thyroxine Ofloxacin Quinidine Fentanyl Non Cross-Reacting Cefadroxil Apomorphine Clindamycin Ethylenediamine Tetraacetic Mannitol Orphenadrine Hydrochloride Quinine Compounds： Cephradine Aprobarbital Clobazam Acid Maprotiline Oxalic Acid R(-)-Epinephrine *Parent compound only: Chloroquine Aspartame Clobetasone Butyrate Ethyl Morphine Mebendazole Oxazepam Ranitidine Chlorpheniramine Atenolol Clomipramine Ethyl-p-aminobenzoate Meclofenamic Acid Oxycodone Riboflavin Acebutolol Chlorpromazine Atropine Clonazepam Etodolac Medazepam Oxymetazoline Ritodrine Acetopromazine-d6 Chlorpropamide Baclofen Clonidine Hydrochloride Etoposide Mefenamic Acid Oxymorphone Roxithromycin Tablets Acetyl-L-cysteine Chlorprothixene Barbituric Acid Clorazepate Dipotassium Famotidine Melanin Oxyphenbutazone Salbutamol (Albuterol ) Acetylsalicylic Acid ( Aspirin ) Chlorthalidone Beclometasone Dipropionate Cloxacillin Fenfluramine Menthol Oxypurinol Salicylic Acid Acetaminophen Chlorzoxazone Beclomethasone Clozapine Fenoprofen Meperidine Paclitaxel Secobarbital O6-Acetylmorphine Chloral Hydrate Bendroflumethiazide Cocaethylene Fentanyl Citrate Salt Meprobamate p-Aminobenzoic Acid Serotonin Acetazolamide Cimetidine Benzalkonium Bromide Cocaine Hydrochloride Ferrous Sulfate Merperidine Pancuronium Bromide Sertraline N-Acetylprocainamide Cinchonidine Benzilic Acid Codeine Flufenamic Acid Metaproterenol Hemisulfate Papaverine Sodium Chloride Acetone Cinoxacin Benzocaine Colchicine Flunisolide Salt Paracetamol Tablets Sodium Cromoglicate Acetophenetidin Cicosporin Benzoic Acid Compound Zinc Undec Flunitrazepam Metaraminol Pargyline Sodium Formate Alprenolol hydrochloride Citric acid Benzoylecogonine Cortisone Fluphenazine Dihydrochloride Methadone PCP Morpholine Anolog Stearic Magnesium Alprazolam Clenbuterol Hydrochloride Benzphetamine Cotinine Flurandrenolide Methamphetamine Penicillin Sulfamethazine Allopurinol Clindamycin Benzthiazide Creatinine Flurazepam Methoxamine Pentobarbital Sulfamethoxazole Alphenal Clobetasone Butyrate Benzyl Alcohol Cyclobenzaprine Hydrochloride Furosemide Sulfanilamide Methoxyamine Hydrochloride Pentoxifylline Amiloride Clomipramine Benzylamine Hydrochloride Cyclopentobarbital Gemfibrozil Sulfathiazole Methoxyphenamine Pentylenetetrazole Aminophenazon Clorazepate Dipotassium Berberine Cyclophosphamide Gentamicin Sulfate Sulindac Methyl Salicylate Perphenazine Amiodarone Hydrochloride Tablets Clonazepam Cyproheptadine Hydrochloride Gentisic Acid Tamoxifen Citrate Betamethasone Methylene Blue Phenacetin Ampicinine(Ampicillin) Clobazam D/L-Tyrosine Tannic Acid Bilirubin Glucose Methylenedioxymethampheta Phencyclidine (PCP) Amitriptyline Cloxacillin Temazepam Bisacodyl Dantrolene Sodium Glutathione Reduced mine-(+/-) 3/4（MDMA） Phenelzine Aminophylline Cholesterol Tenoxicam Bromazepam D-Aspartic Acid Glybenclamide Methylphenidate Phenformin Amantadine Hydrochloride (-)-Cotinine Terbutaline Bromocriptine Mesylate Deferoxamine Mesylate Griseofulvin Meticrane Pheniramine Amphotericin B Cocaethylene Terfenadine Bupivacaine Delta-8-THC Halcinonide Metoclopromide Hydrochloride Phenobarbital Ammonium Chloride Cocaine Hydrochloride Tetracycline Buprenorphine Deoxyepinephrine Haloperidol Metronidazole Phenol Amphetamine Sulfate Codeine Tetraethylthiuram Disulfide Bupropion Hydrochloride Desipramine Hemoglobin Mianserin Phenolphthalien Amikacin Creatinine Tetrahydrocannabinol, Delta-9- Buspirone Desoximetasone Heroin Midazolam Phenothiazine Amikacin sulfate Cyclobenzaprine Hydrochloride Tetrahydrozoline Butabarbital Dexamethasone Hexachlorophene Milrinone Phentermine p-Aminobenzoic Acid L-Cystine Thebaine Butacaine Dextromethorphan Hippuric Acid Minaprine Phenylbutazone DL-Aminoglutethimide Cyproheptadine Hydrochloride Theobromine Butalbital Hydrobromide Histamine Morphine Phenylephrine-L Anamycin sulfate Cyclopentobarbital Theophylline Butethal Diazepam Hydralazine Nabumetone Phenylethylamine Aniline Dantrolene sodium Butyrophenone Diazoxide Hydrochlorothiazide N-Acetylprocainamide Phenylpropanolamine Thiamine Antipyrine Dextromethorphan hydrobromide Caffeine Dieldrin Hydrocodone Nadolol Phenyltoloxamine Thioridazine Hydrochloride Apomorphine Dexamethasone Camphor Diflorasone Diacetate Hydrocortisone Nafcillin p-Hydroxymethamphetamine Tobramycin Aprobarbital Deoxyepinephrine Cannabidiol Diflunisal Hydroflumethiazide Nalbuphine Picrotoxin Tolazamide Aspartame Deferoxamine Mesylate Canrenoic Acid Digoxin Hydromorphone Nalidixic Acid Pilocarpine Tolbutamide L-Ascorbic Acid Desipramine Captopril Dihydralazine Hydroxocobalamin Nalmefene Pimozide Tolmetin L-Aspartic Acid Dimethyl Isosorbide Carbamazepine Dimethyl Isosorbide Hydroxyprogesterone Nalorphine Hydrochloride Pipecolic Acid Tramadol D-Aspartic Acid Diazepam Carisoprodol Dimethyl Sulfoxide Hydroxyurea Naloxone Hydrochloride Piroxicam Trans-2-Phenylcyclo-Propylamine DL-Aspartic Acid Diflorasone Diacetate Cefaclor Dipyridamole Hydroxyzine Dihydrochloride Naltrexone Hydrochloride Potassium Chloride Hydrochloride Atropine Diflunisal (+)3,4-Methylenedioxyamphetamine (+)3,4-Methylenedioxymethamphetamine Hydroxyurea Haloperidol salicylate Methyl hydrochloride Methoxyamine salt hemisulfate Metaproterenol Norfludiazepam Oxymorphone Ofloxacin Picrotoxin Potassium chloride Pargyline Propionylpromazine Sertraline Trichlormethiazide Trimethoprim L-Thyroxine Vincamine Vanillic acid diethylamine Tramadol Non Cross-Reacting Compounds *Parent compound only: Sulfamethoxazole Sulfisoxazole Sulindac Sulfathiazole Sulfanilamide Citrate Tamoxifen Tannic Acid Tenoxicam Terfenadine Terbutaline disulfide Tetraethylthiuram Tetracycline Thebaine Theobromine Thiamine Theophylline Tobramycin Tolazamide Tolbutamide Tolmetin Triprolidine Tramadol Trazodone 2, 4, 6-trmethylbezamide Tropic Acid Tropine D/L-Tyrosine Trichloroacetic acid Trimipramine Tryptamine Trifluoperazine D, L-Tryptophan Triazolam Trans-2-phenylcyclo-propylamine hydrochloride Tyramine Uric Acid Urea Vancomycin HCL Venlafaxine hydrochloride Verapamil Xylometazoline hydrochloride Yohimbine Zearalenone Zomepirac Zopiclone Albumin,Human recombinant Atenolol Benzthiazide Beclomethasone Bupropion hydrochloride Benzalkonium bromide Chlorothiazide Camphor Clonidine hydrochloride Canrenoic acid Captopril Clozapine Chloramphenicol Cortisone a-Chymotrypsin Cetirizine Hydrochloride Tablets Dipyridamole Desoximetasone R(-)-Epinephrine Emetine dihydro-chloride hydrate Ethyl acetate Fluphenazine dihydrochloride (+/-)-4-Hydroxyamphetamine HCL Oxymetazoline Oxyphenbutazone Oxypurinol Bromide Pancuronium Papaverine tablets Paracetamol Paclitaxel Anolog PCP Morpholine Pentobarbital Pentylenetetrazole Pentoxifylline Perphenazine Phenelzine Penicillin Phenacetin Phencyclidine(PCP) Phenformin Pheniramine Phenobarbital Phenothiazine Phenol Phenolphthalien Phentermine P-phenylene Phenylephrine-L Phenylbutazone Phenylethylamine Phenylpropanolamine Phenyltoloxamine Pilocarpine Pimozide Pipecolic Acid Piroxicam Potassium Iodide Prazepam Prednisolone Acetate Prilocaine Primaquine diphosphate Primidone Proadifen Probenecid Procainamide hydrochloride Procaine Procyclidine Promazine Promethazine Propoxyphene,d- Propranolol Protriptyline Pseudoephedrine HCL Pyridine-2-Aldoxime Pyridoxine Pyrilamine 2, 3-pyridine dicarboxylic acid Quinine Quinidine Quinacrine Sodium chloride Ritodrine Roxithromycin tablets Ranitidine Riboflavin Salbutamol (Albuterol ) Salicylic Acid Secobarbital Serotonin Sodium Cromoglicate Sodium Formate Stearic magnesium Sulfamethazine Isoxsuprine Isoproterenol-(+/-) Ketamine Acid Kynurenic Labetalol Lactose Levorphanol Lidocaine Lithium Carbonate Lorazepam glucuronide Mannitol Maprotiline Mebendazole Meclofenamic Acid Medazepam Mefenamic Acid Melanin Meperidine Meprobamate Merperidine Metaraminol Methamphetamine D-methamphetamine o-Methoxyanime HCL Methoxyphenamine Methylene Blue Methylphenidate Meticrane Metoclopromide Hydrochloride Metronidazole 4-Metylumbelliferyl B-D-glucuronide hydrate Mianserin Milrinone Minaprine Morphine Nabumetone Nadolol Nafcillin Nalbuphine Nalorphine hydrochloride Naphthol Naproxen Naphazoline hydrochloride 1-Naphthylacetic acid1 Naloxone hydrochloride Nalmefene Neomycin Sulfate Nialamide Niacinamide (+/-) Nicotine Nimesulide Nitrazepam Nifedipine Nicotinic Acid Nitrofurantoin Norchlordiazepoxide Norclomipramine Nordiazepam Nordoxepin Norfloxacin Norethindrone Norpropoxyphene Noscapine Nomifensine Nortriptyline Hydrochloride Nylidrin Octopamine Orphenadrine hydrochloride Oxalic Acid Oxazepam ） Cyclobarbital （ -Hydroxyhippuric acid Hydrocodone Hydroxocobalamin hydrochloride ａ Hydroxyzine dihydrochloride a-Hydroxyalprazolam Hydroxyprogesterone p-Hydroxymethamphetamine Hydrocortisone Hydrochlorothiazide Ibuprofen Imipramine Imidazole Indapamide Indomethacin Ipratropium Bromide Isonicotinic Acid Hippuric Acid Histamine Hydralazine Diazoxide Diazoxide Dieldrin Dipyrone 5,5-Diphenylhydantoin acid D,L-3,4-Dihydroxymandelic Dihydralazine Hemoglobin Disopyramide Dopamine Dobutamine Doxepin Hytclate Doxycycline Doxylamine Droperidol Ecgonine methylester Ephedrine-(+/-) Erythromycin Eserine Estazolam Estradiol,17B- Estriol Estrone Estrone-3-sulfate Etoposide Ethacrynic Acid Ethambutol Ethyl-p-aminobenzoate Ethylenediamine Tetraacetic Etodolac EthylMorphine Famotidine Fenfluramine Ferrous Sulfate Fenoprofen Flufenamic Acid Flunitrazepam Flunisolide Flurandrenolide Flurazepam Furosemide Gentamicin Sulfate Glutathione reduced Glybenclamide Griseofulvin Halcinonide Heroin Hexachlorophene Hypnoval Hydroflumethiazide Hydromorphone

PN: Y0311117405 Butabarbital Procaine HCL Benzoylecgonine Labetalol Hydrochloride Prednisolone Guaifenesin Guaiacol glyceryl ether Promazine hydrochloride SS Benzoic Acid Levorphanol Prednisone Acetate Hippuric Acid Promethazine Bilirubin, Mixed Isomers Loperamide Hydrochloride Procaine HCL Hydralazine hydrochloride Propranolol Hydrochloride Brompheniramine Maleate Loxapine Succinate Salt Promazine Hydrochloride Hydrochlorothiazide D-Propoxyphene Buspirone Hydrochloride Maprotiline Hydrochloride Promethazine Methylenedioxypyrovalerone Hydrocodone Pseudoephedrine HCL Butabarbital (±)-3,4-Methylenedioxyethylamphetamine D-Propoxyphene Non Cross-Reacting Hydrocortisone Quinacrine Cannabidiol (±)-3,4-Methylenedioxyamphetamine Propranolol Hydrochloride Compounds O-Hydroxyhippuric acid Quinidine Cannabinol Meperidine Pseudoephedrine HCL *Parent compound only: 3-Hydroxytyramine Quinine Caffeine Meprobamate Quinine Chlordiazepoxide HCL Methamphetamine Hydrochloride Ibuprofen Ranitidine Hydrochloride Quinidine Chlorothiazide (±)Methadone Quinacrine Dihydrochloride Imipramine HCL Salicylic acid Acetpromazine－d6 hydrochloride Chloroquine Diphosphate S(+)-Methamphetamine Ranitidine Hydrochloride Iprazid Sertraline HCI Acetaminophen Chlorpheniramine Maleate L-methamphetamine Salicylic Acid N-Acetylprocainamide Isoproterenol Hydrochloride Serotonin HCI Chlorpromazine Hydrochloride Methoxyphenamine Hydrochloride Secobarbital Aspirin Isoxsuprine hydrochloride Secobarbital Chloramphenicol Methylphenidate Serotonin HCL 4-Dimethylaminoantipyrine Ketamine hydrochloride Sulfamethazine Chloral Hydrate (±)-3,4-Methylenedioxymethamphetamine Sertraline HCL Amitryptyline Ketoprofen Sulindac Cholesterol Methyprylon Sulfamethazine Amobarbital Labetalol Hydrochloride Temazepam Chlorothiazide Sulindac Amoxicillin Levorphanol Acetophenetidin Clomipramine Hydrochloride Morphine Sulfate Salt Solution Temazepam Ampicillin Loperamide Hydrochloride S（+）Amphetamine Clonidine Hydrochloride Nalidixic Acid Tetracycline Ascorbic acid Loxapine succinate salt Tetracycline (-) Cotinine Nalorphine Hydrochloride Tetrahydrozoline Hydrochloride (±)Amphetamine Maprotiline hydrochloride Tetrahydrocortisone3 Cocaethylene Naproxen Apomorphine Meperidine (5-Dglucuronide) Cocaine Hydrochloride Naloxone Thebaine Aspartame Meprobamate Tetrahydrozoline hydrochloride Codeine Naltrexone Hydrochloride Theophylline Atropine (±)Methadone Thebaine Cortisone Nicotinamide (Vitamin B3) Thioridazine Benzilic acid D-methamphetamine Thiamine Creatinine Nimesulide Thiamine, (Vitamin B1) HCL Dextromethorphan Benzoic acid Methoxyphenamine hydrochloride Thioridazine Nifedipine L-Thyroxine Diazepam Norcodeine Tolbutamide Benzoylecgonine Noroxymorphone HCL D, L-Thyroxine Diclofenac Sodium Nordoxepin Hydrochloride Trimethoprim Benzphetamine HCL (±)-MDA Tolbutamine Methylenedioxymethamphetamine-(+/-)3/4 L-methamphetamine Dicyclomine Norethisterone Trazodone Hydrochloride Bilirubin Diflunisal (MDMA) Triamterene D-Norpropoxyphene Maleate Salt Triamterene Caffeine Digoxin Noscapine HCL Hydrate Trimipramine Methaqualone Trifluoperazine dihydrochloride Cannabidiol 4-Dimethylaminoantipyrine Noroxymorphone HCL Tryptamine Methylphenidate Trimethoprim Cannabinol 5,5-Diphenylhydantoin Nylidrin Hydrochloride Trifluoperazine Dihydrochloride Chloralhydrate Trimipramine Diphenhydramine (±)-Octopamine HCL DL-Tryptophan Chloramphenicol Nalorphine Trans-2-phenylcyclo-propylamine Dopamine Hydrochloride Oxalic Acid Trans-2-Phenylcyclopropylamine Chlorothiazide Naloxone hydrochloride Doxylamine Succinate Salt Oxazepam Hydrochloride Chlorothiazide Nalidixic acid Tryptamine Ecgonine Methyl Ester Oxolinic Acid DL-Tyrosine Chlorpheniramine Maleate Naltrexone hydrochloride Chlordiazepoxide HCL Ecgonine HCL Oxycodone Tyramine Chlorpromazine Hydrochloride Naproxen Trazodone Efavirenz Oxymetazoline Hydrochloride Uric Acid Chlorpheniramine Maleate Nicotinamide Buspirone hydrochloride Emetine Dihydrochloride Hydrate Papaverine Hydrochloride Verapamil Hydrochloride Cholesterol Morphine sulfate salt solution D, L-Tryptophan (-)-Epinephrine Phencyclidine Zomepirac Sodium Salt Clomipramine Hydrochloride Nifedipine Tyramine Ephedrine-(±) Hydrochloride Pentobarbital Clonidine hydrochloride Norcodein D/L-Tyrosine (-)-Ephedrine HCL Pentazocine Cocaethylene Norethindrone Uric acid (1R,2S)-(-)-Ephedrine Perphenazine The Other Few Non Cocaine hydrochloride d-Norpropoxyphene Verapamil Hydrochloride Erythromycin Penicillin G Sodium Salt Cross-Reacting Compounds Codeine Noscapine HCL d,I-Metamfepramone HCL Estradiol Phenelzine Sulfate Salt of BUP at Concentration of Cortisone (±)-Octopamine HCL Estrone-3-Sulfate Potassium Salt Phenobarbital Ethyl-P-Aminobenzoate Phentermine HCL (-) Cotinine Oxalic acid Ethyl Glucuronide Fenoprofen Calcium Salt Hydrate Phenylethylamine Creatinine Oxazepam Non Cross-Reacting Compounds Furosemide L-Phenylephrine Codeine 21-Hydroxy progesterone Oxolinic acid Gentisic Acid Morphine Oxycodone *Parent compound only: Phenylpropanolamine Hydrochloride Dextromethorphan D-Glucuronic Acid Oxymetazoline Hydrochloride (-)-Ephedrine HCL Glutethimide Methamphetamine hydrochloride p-Hydroxymethamphetamine Acebutolol Hydrochloride Guaifenesin (Guaiacol Glyceryl Ether) BIBLIOGRAPHY Diphenhydramine Papaverine hydrochloride Acepromazine-d6 Hydrochloride Hemoglobin Porcine Doxylamine Penicillin-G Acetaminophen Hippuric Acid 1. Stewart DJ, Inaba T, Lucassen M, Kalow W. Clin. Pharmacol. Ther. April 1979; 25 ed: 464, 264-8. 5,5-Diphenylhydantoin Pentobarbital N-Acetylprocainamide Hydralazine Hydrochloride Ecgonine hydrochloride Perphenazine Acetophenetidin Hydrocodone 2. Ambre J. J. Anal. Toxicol. 1985; 9:241. Ecgonine methylester Phenelzine Amoxicillin 3. Hawks RL, CN Chiang. Urine Testing for Drugs of Abuse. National Institute for Drug Abuse (NIDA), Research Ephedrine-(+/-) hydrochloride PCP Ampicillin 21-Hydroxyprogesterone Monograph 73, 1986. [1R,2S] (-) Ephedrine Phenobarbital Amitriptyline Hydrochloride p-Hydroxymethamphetamine 4. Tietz NW. Textbook of Clinical Chemistry. W.B. Saunders Company. 1986; 1735. (-)-Epinephrine Acebutolol Hydrochloride S(-)-Amphetamine Hydrocortisone 5. FDA Guidance Document: Guidance for Premarket Submission for Kits for Screening Drugs of Abuse to be R(-)-Amphetamine Erythromycin R(-)-Amphetamine Hydrochlorothiazide Used by the Consumer, 1997. Amobarbital Estradiol Phentermine HCL (±)- 4-Hydroxyamphetamine HCL 6. Robert DeCresce. Drug Testing in the workplace, 114. (±)Amphetamine Estrone-3-sulfate (+/-)-4-Hydroxyamphetamine HCL Ibuprofen 7. Baselt RC. Disposition of Toxic Drugs and Chemicals in Man. 2nd Ed. Biomedical Publ., Davis, CA 1982; 487. R-(-)-Apomorphine Hydrochloride Hemihydrate Pentazocine Imipramine HCL 8. OSHA, The Bloodborne Pathogens Standard 29, Code of Federal Regulations 29 CFR 1910.1030. Fenoprofen Aspirin L-Phenylephrine Iprazid 9. CDC, Centers forDisease Control (CDC) Guidelines, Morbidity and Mortality Weekly Report, Volume 37, Furosemide Aspartame Gentisic acid Phenylpropanolamine hydrochloride Isoxsuprine Hydrochloride Number 24, 1988. L-Ascorbic Acid Isoproterenol Hydrochloride Hemoglobin porcine 2-phenylethylamine HCL 10. Auwarter V et. al. ‘Spice’ and other herbal blends: harmless incense or cannabinoid designer drugs? J. Mass Atropine Ketamine Hydrochloride D-Glucuronic acid Prednisolone Spectrom. 44: 832-837 (2009). Benzphetamine HCL Ketoprofen Glutethimide Prednisone Benzilic Acid 11. U.S Drug Enforcement Administration (DEA). Drugs and Chemicals of Concern: JWH-073. (2009). 12.U.S. Drug Enforcement Administration (DEA). Drugs and Chemicals of Concern: JWH-018. (2009). 13. "WCPI Focus on Pain Series: The Three Faces of Fentanyl". Aspi.wisc.edu. Retrieved 2010-07-28. 14. "FENTANYL : Incapacitating Agent". CDC. Retrieved 2014-09-18. 15. Mutschler, Ernst; Schäfer-Korting, Monika (2001). Arzneimittelwirkungen (in German) (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. p. 286. ISBN 3-8047-1763-2. 16. Parry WH, Martorano F, Cotton EK (January 1976). "Management of life-threatening asthma with intravenous isoproterenol infusions".Am. J. Dis. Child.130(1):39–42. doi:10.1001/archpedi.1976.02120020041006. 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Ethyl Glucuronide: A Biomarker to identify Alcohol use by Health Professionals Recovering from Substance use Disorders. Skipper G.E et al. Alcohol and Alcoholism, 2004, 39(5):445-449. 25. Ethyl Glucuronide- A marker of Recent Alcohol Consumption with Clinical and Forensic Implications. Wurst FM et al. Alcohol. 2000, 20(2):111-116. 26. Ethyl Glucuronide (EtG): A new marker to detect Alcohol use in recovering physicians., Skipper G.E., et al. Journal of Medical Licensure and Discipline. 2004, 90(2): 14-17. 27. Production of urinary ethanol after sample collection. Saady, J.J., Poklis, A.and Dalton, H.P. (1993) Journal of Forensic Sciences 38, 1467-1471. 28. Preliminary immunochemical test for the determination of Ethyl Glucuronide in serum and urine: Comparison of screening method results with Gas Chromatography- Mass spectrometry. Zimmer H., et al. Journal of Analytical Toxicology. 2002, 26:11-16. 29. Confirmatory Analysis of Ethyl Glucuronide in urine by liquid chromatography/ElctrosprayIonization/Tandem Mass Spectrometry according to forensic guidelines. Weinmann W. et al. J. Am. Soc. Mass Spectrom. 2004, 15(2):188-193.

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