CURRICULUM VITAE 4/2000
NAME: Elizabeth Ann Young
EDUCATION:
1963-1967 Regina Dominican High School Wilmette, Illinois
1967-1971 B.S. in Biology (cum laude) from the University of Dayton, Dayton, Ohio with emphasis in molecular biology, chemistry, and psychology
1971-1973 Graduate School, Department of Medical Microbiology, Ohio State University
1973-1976 Ohio State University College of Medicine with M.D. awarded in June, 1976
POST-GRADUATE TRAINING:
1976-1979 Resident in Psychiatry, Department of Psychiatry, Ohio State University
1979-1984 University of Michigan Research Fellow, Psychiatry Clinical Studies Unit, Department of Psychiatry, University of Michigan
ACADEMIC APPOINTMENTS:
1976-1979 Clinical Instructor, Department of Psychiatry, Ohio State University
1984-1991 Assistant Professor, Department of Psychiatry, University of Michigan
1991-1998 Associate Professor, Department of Psychiatry, University of Michigan
1998-present Professor, Department of Psychiatry, University of Michigan Curriculum Vitae 2 Elizabeth Ann Young
RESEARCH APPOINTMENTS:
1979-1981 Clinical Research Fellow, Department of Psychiatry, University of Michigan
1981-1982 N.R.S.A. Individual Postdoctoral Fellowship, University of Michigan, under the direction of Drs. Stanley Watson and Huda Akil
1982-1984 M.H.R.I. Fellowship, University of Michigan, under Drs. Stanley J. Watson and Huda Akil
1984-1991 Research Investigator, Mental Health .Research Institute
1991-1998 Associate Research Scientist, Mental Health Research Institute Associate Research Scientist, Reproductive Sciences Program
1998-present Senior Research Scientist, Mental Health Research Institute
SCIENTIFIC ACTIVITIES:
1992-1996 Member, NIMH IRG, Biological Psychopathology and Clinical Neurosciences Review committee
1992-present Special Review Committees and ad hoc reviewers at least once per year for NIMH, NIGMS, NCRR
1995-1998 Member Program Committee for Society of Biological Psychiatry
1995-1998 Member Program Committee for Endocrine Society
1995, 1997 Member Program Committee for Psychoneuroendocrinology
1995-present Member, Editorial Board of Molecular Psychiatry
1997-present Member, Editorial Board of Biological Psychiatry
Sept, 1996 Co-Chairman of Mental Health and Addictive Disorders Subsection of "Beyond Hunt Valley: A Re-evaluation of the Women's Health Agenda", Office of Research on Women's Health, NIH
1998-present Member, Editorial Board of Psychoneuroendocrinology
1999-present Member, Editorial Board of Neuropsychopharmacology
Reviewer for numerous journals including Archives of General Psychiatry, Biological Psychiatry, Curriculum Vitae 3 Elizabeth Ann Young
Psychiatry Research, Psychoneuroendocrinology, Endocrinology, Journal Clinical Endocrinology and Metabolism, American Journal of Physiology, Brain Research, Depression, Neuroendocrinology, J Neuroendocrinology.
GRANT SUPPORT:
1981-1982 N.R.S.A. Individual Postdoctoral award, $18, 468
1984-1989 NIMH Research Scientist Development Award, Level I Hypothalamo-Pituitary Adrenal Axis in Depression
1990-2000 NIMH Research Scientist Development Award, Level II Hypothalamo-Pituitary Adrenal Axis in Depression Current budget year $77, 756
1990-1995 Cortisol Feedback in Diurnal Rhythm NIMH FIRST AWARD $350,000 total
1991-1994 Cellular Immunity in Depressive Illness Co-investigator Ziad Kronfol, Principal Investigator, $448, 481 total
1992-2001 Molecular Elements, Neurocircuits, and Mental Illness Project 4 Human Neuroendocrine Studies Elizabeth Young, Co-Pricipal investigator Stanley J.Watson, Co-Principal Investigator Current budget year: $137, 665
1994-1998 Stress and Reproductive Hormones in Depressed Women, PI Current budget year: $152, 089
1998-2002 The Biology of Comorbid Mood and Anxiety, Elizabeth Young, PI, Oliver Cameron and James Abelson, Co-investigators Current budget year: $186,000
1998-2003 Cortisol in Post Traumatic Stress Disorder, PI of UM subcontract to Henry Ford Hospital for " PTSD: a Follow-up Years 11-15". Naomi Breslau, PI $28,500 (direct costs subcontract)
CERTIFICATION AND LICENSURE:
1976 Licensed to practice medicine, State of Ohio #039856
1979 Licensed to practice medicine, State of Michigan # 041187 Curriculum Vitae 4 Elizabeth Ann Young
1981 Board certified in Psychiatry, American Board of Psychiatry and Neurology
HONORS :
1967-1971 Dean's List, University of Dayton
1970 National Science Foundation summer research fellow, Department of Biology, under Dr. George McDougall in the area of fungal genetics
1969-1971 Alpha Epsilon Delta, International Premedical Honor Society
1977-1978 Chief Resident in Psychiatry, Department of Psychiatry, Ohio State University
1978 Recipient of Sandoz Award for outstanding resident of the year in the Department of Psychiatry, Ohio State University College of Medicine
MEMBERSHIPS IN PROFESSIONAL SOCIETIES :
1987 Member, Society of Biological Psychiatry
1987 Member, Society for Neuroscience
1988 Member, International Society for Psychoneuroendocrinology
1991 Member, Endocrine Society
1996-present Member, American College of Nueropsychopharmacology
TEACHING
Formal
1987-present Basic Neuroscience Course for Psychiatry Residents and Neuroscience graduate students, along with Drs. S.J. Watson and H. Akil 1987 Supervisor for summer research project for Alan Mishra, medical Curriculum Vitae 5 Elizabeth Ann Young
student 1988 DART conferences for mental health professionals 1988-1993 Monthly teaching rounds with CRC Residents 1988 Supervisor of research elective for medical student David Diehl 1990 Supervisor for summer research project for Juliet Kottak, medical student 1990 Ph.D. Dissertation Committee for Seung Kwak, Neuroscience student 1992-1996 Graduate Advisor, PhD. student from Physiology, Patti Liberman 1992-present Lectures to medical students rotating through Psychiatry, approximately 3-4 per year 1992-present Lectures to 3rd and 4th year Psychiatry residents on depression, treatment 1993-1995 PhD. dissertation committee for Hal Cantor 1993-present PhD. dissertation committee for Geneal Brooks 1994,-present Lectures to 4th year Pharmacology Elective Medical Students 1994-present Lectures for "Psychiatry Science in the Clinics" for 4th year medical students 1994-1997 PhD. dissertation committee for Genene Holt, Neuroscience graduate student 1995-present Directory of PGY-2 Psychiatry Core on Depression
Informal 1992-present Attending and supervising psychiatry residents on outpatient teams
Teaching undergraduates working with me: Jeff Nabonsal (1985-1987), Maureen Fitzpatrick (1986-1988), Patrick Killilea (1988), and Johan Samanta (1988-1990), Christina Barr (1991-1993); Kristina Fried (1993- 1994), Kurt Hafer (1993-1995), Melissa Krstov (1995) Valerie Press (1995-1997)
EXTRAMURAL INVITED PRESENTATIONS:
Young EA Rapid effects of glucocorticoids on HPA axis secretion. Invited Speaker for a Symposium at The Annual Meeting of the American College of Neuropsychopharmacology, Maui, December, 1989.
Stress and Adpatation: Basic Science Studies, APA Invited Symposium Speaker, May 25, 1993
Glucocorticoid Feedback in Depression, Invited Symposium Speaker , 9th World Congress of Psychiatry Meeting, Rio de Janiero, Brazil June 9, 1993
Negative Feedback Regulation Of Proopiomelanocortin In Depression Elizabeth A. Young, Huda Akil, Stanley J. Watson, Invited speaker, International Society of Psychoneuroendocrinology (ISPNE), Seattle Washington, August 1994. Curriculum Vitae 6 Elizabeth Ann Young
Glucocortisoid Cascade Hypothesis Revisited: Role of Gonadal Steroids, Workshop on Depression and Women, NIMH, November 4, 1993
Adaptive and Pathological Consequences of Repeated Stress, invited symposium discussant, ACNP symposium December, 1994, San Juan PR.
Influence of Gonadal Steroids on the HPA axis in Depressed Women and Normal Subjects, Workshop on the Psychobiology of Infertility, NICHD, September 21, 1995
Hypothalamic-Pituitary-Adrenal Dysregulation in Depression , Symposium presentation, Third International Symposium on Refractory Depression, October, 1995.
Hypercortisolemia, hippocampal glucocorticoid receptors and fast feedback, NIMH Seminar in Molecular Psychiatry at the Clinical Neuroendocrinology Branch, March 14, 1996
Depression, Ovarian Steroids and the HPA Axis, APA Invited Symposium Speaker, May 6, 1996
Brain Circuits in Control of HPA Axis Activations, APA Invited Symposium Speaker, May 8, 1996
Stress and Depression in Women, ACNP Regional Meeting, New York City, October 1996
Stress, Depression and Hormones, University of North Carolina Grand Rounds March 27, 1997
Stress, Depression and Hormones, Stanford University, April 17 1997
Women, Stress, Depression and Hormones Invited Speaker, International Society of Psychoneuroendocrinology XXVIIth Annual Meeting, San Francisco, July 28, 1997
Stress and Depression in Women, Invited Speaker symposium to ECNP, Vienna Austria, September, 1997
Neuroendocrine Regulation in Depression, Invited Speaker to a presidential workshop, Rockefeller University, March 1998
Gender and Hormonal Life in the Regulation of Stress, Invited Speaker to Columbia University Symposium on "Gender and Depression:Issues for a New Millenium" May 1, 1998 Curriculum Vitae 7 Elizabeth Ann Young
Ovarian Hormones And The Regulation Of Stress Systems, Invited Symposium Speaker to World Stress Meetings, Melbourne Australia, October 1998
Stress and Reproductive Hormones in Depression, University of Minnesota, Jan 2000
Depression and StressHormones in Clinic and Home Settings, University of Cardiff, March 2000
Stress Hormone Systems in Depression, University of Bristol, March 2000
Women, stress, depression and hormones, Yale University, June 2000
Gender Differences In The Regulation Of The Hypothalamic-Pituitary Adrenal Axis, Symposium presentation at the Second International Conference on Hormones, Brain and Neuropharmacology, July 2000.
COMMITTEE AND ADMINISTRATIVE SERVICES:
1985-1993 Psychiatry representitive, UM Hospital IRB
1988 MHRI Library Committee
1989 Biometrics Commmittee
1989-present MHRI Seminar Series Committee
1990-present Psychiatry Department Major Conference Series
1992-present Psychiatry, Appointments and Promotion Committee
1993-present Operating Committee, General-CRC
1993-1997 Reproductive Sciences Program Speaker's Selection Committee
1993-1995 Reproductive Sciences Program Training Grant Selection Committee
1994-1998 Reproductive Sciences Program P 30 Core Steering Committee
1995-1998 Reproductive Sciences Program Executive Committee
BIBLIOGRAPHY Curriculum Vitae 8 Elizabeth Ann Young
Completed Publications In Peer Reviewed Scientific Journals:
1. Pariser, S.F., Young, E.A., Jones, B.A., Pinta, E.R., and Paul, L.G.: Depression: A new approach to an old syndrome. Am Fam Physician, 18(4), 1978.
2. Pariser, S.F., Jones, B.A., Pinta, E.R., Young, E.A., and Fontane, M.E.: Panic attacks: Diagnostic evaluations of 17 patients. Am J Psychiatry, 136(1):105, 1979.
3. Harris, L.F., Hamparian, V.V., Young, E.A., and Hughes, J.H.: Lymphocyte transformation for detecting herpes virus induced tumor associated antigen. Cancer Res, 39:3946-4002, 1979.
4. Feinberg, M., DeVigne, J.P., Kronfol, Z., and Young, E.A.: The duration of action of phenelzine. Am J Psychiatry, 138:379-380, 1981.
5. Carroll, B.J., Feinberg, M., Greden, J.F., Tarika, J., Albala, A.A., Haskett, R.F., Jams, N., Kronfol, Z., Lohr, N., Steiner, M., DeVigne, J.P., and Young, E.A.: A specific laboratory test for the diagnosis of melancholia. Arch Gen Psychiatry, 38(1):15-22, 1981.
6. Akil, H., Young, E.A., Watson, S.J., and Coy, D.H.: Opiate binding properties of naturally occurring N- and C-terminus modified beta-endorphin. Peptides, 2:289-292, 1981.
7. Young, E.A., Olney, J., and Akil, H.: Increase in delta, but not mu, receptors in MSG-treated rats. Life Sciences, 31:1343-1346, 1982.
8. Walker, J.M., Moises, H., Coy, D., Young, E., Watson, S.J., and Akil, H.: Dynorphin-(1-17): Lack of analgesia but evidence for non-opiate electrophysiological and motor effects. Life Sciences, 31:1821-1824, 1982.
9. Young, E.A., Walker, J.M., Houghten, R., and Akil, H.: [3H]Dynorphin A binds selectively to guinea pig brain. Eur J Pharmacol, 91:327-328, 1983.
10. Young, E.A., Olney, J., and Akil, H.: Selective alterations of opiate receptor subtypes in monosodium glutamate-treated rats. J Neurochem, 40(6):1558-1564, 1983.
11. Young, E.A., Walker, J.M., Houghten, R., and Akil, H.: [3H]Dynorphin binding to guinea pig and rat brain. Life Sciences, 33:287-290, 1983.
12. Lewis, M.E., Young, E.A., Houghten, R.H., Akil, H., and Watson, S.J.: Binding of [3H]Dynorphin A to apparent kappa receptors in the deep layers of guinea pig cortex. Eur J Pharmacol, 98:149- 150, 1984.
13. Young, E.A. and Akil, H.: Changes in releasability of ACTH and beta-endorphin with chronic stress. Neuropeptides, 5:545-548, 1985.
14. Young, E.A. and Akil, H.: CRF stimulation of ACTH/beta-endorphin release: Effect of acute and Curriculum Vitae 9 Elizabeth Ann Young
chronic stress. Endocrinology, 117:23-30, 1985.
15. Young, E.A., Walker, J.M., Lewis, M.E., Houghten, R., Woods, J.H., and Akil, H.: [3H]Dynorphin binding and kappa selectivity of pro-dynorphin peptides in rat, guinea pig, and monkey brain. Eur J Pharmacol, 121:355-365, 1986.
16. Young, E.A., Lewis, J., and Akil, H.: The preferential release of beta-endorphin from the anterior lobe of CRF. Peptides, 7:603-607, 1986.
17. Robinson, T.E., Becker, J.B., Young, E.A., Akil, H., and Castaneda, E.: The effects of footshock stress on regional brain dopamine metabolism and pituitary beta-endorphin release in rats previously sensitized to amphetamine. Neuropharmacology, 26(7A):679-691, 1987.
18. Young, E.A., Walker, J.M., Houghten, R., and Akil, H.: The degradation of Dynorphin A in brain tissue in vivo and in vitro. Peptides, 8:701-707, 1987.
19. Watson, S.J., Lopez, J., Young, E.A., Vale, W., Rivier, J., Akil, H.: Effects of low dose oCRH in humans: Endocrine relationships and β-endorphin/β-lipotropin responses. J Clin Endocrinol Metab, 66:10-15, 1988.
20. Walker, J.M., Coy, D.H., Young, E.A., Baldrighi, G., Siegel, S.F., and Akil, H.: D-Ala2- 4 pentaflourophenylalanine -dynorphin 1-13-NH2 (DAFPHEDYN): A potent kappa-selective analog of dynorphin. Peptides, 8:811-817, 1987.
21. Young, E.A. and Akil, H.: Paradoxical effect of corticosteroids on pituitary ACTH/β-endorphin release in stressed animals. Psychoneuroendocrinology, 13: 317, 1988.
22. Young, E.A., Houghten, R., and Akil, H.: Plasma conversion of β-endorphin to γ-endorphin and induction with chronic stress. Eur J Pharmacol, 167: 229-236, 1989
23. Young, E.A., Adrenalectomy increases β-Lipotropin secretion over β-endorphin secretion from anterior pituitary corticotrophs. Life Sciences, 45:2233-37, 1989.
24. Herman, J.P., Schafer, M.K.-H., Young, E.A., Thompson, R.C., Douglass, J.O., Akil, H., and Watson, S.J.: Hippocampal regulation of the hypothalamo-pituitary-adrenocortical axis: In situ hybridization analysis of CRF and vasopressin messenger RNA expression in the hypothalamic paraventricular nucleus following hippocampectomy. J. Neuroscience, 9:3072-3082, 1989.
25. Herman, J.P., Schafer, M. K., Sladek, C., Day, R., Young, E.A., Akil, H., Watson, S.J.: Chronic electroconvulsive shock treatment elicits up-regulation of CRF andAVP mRNA in select populations of neuroendocrine neurons. Brain Research, 501:235-246, 1989.
26. Young, E.A., Watson, S.J., Kotun, J., Haskett, R.F., Grunhaus, L., Murphy-Weinberg, V., Vale, W., Rivier, J., and Akil, H.: Response to low dose oCRH in endogenous depression: role of cortisol feedback. Archives of General Psychiatry, 47:449-57, 1990. . Curriculum Vitae 10 Elizabeth Ann Young
27. Young, E.A., Akana, S., Dallman, M.F.: Decreased sensitivity to glucocorticoid fast feedback in chronically stressed rats. Neuroendocrinology, 51: 536-542, 1990.
28. Spencer, R.L., Young, E.A., Choo, P.H., McEwen, B.S. : Glucocorticoid Type I and Type II receptor binding: estimates of in vivo receptor number, occupancy and activation with varying levels of steroid. Brain Research, 514: 37-48, 1990.
29. Young, E.A.: Induction of the intermediate lobe POMC system with chronic swim stress and β- adrenergic modulation of this induction.Neuroendocrinology, 52:405-414, 1990
30. Young, E. A., Spencer, R. L., McEwen B.S. Changes at Multiple levels of the Hypothalamic Pituitary Adrenal Axis Following Repeated ECS. Psychoneuroendocrinology, 15:165-172, 1990.
31 Young, E.A., Grunhaus, L. Haskett, R.F., Pande A. C. , Murphy-Weinberg, V., Watson, S.J., Akil, H. : Heterogeneity in the β-endorphin response to Electroconvulsive Therapy Arch Gen Psychiatry, 48: 534-39, 1991
32. Young, E. A. , Haskett, R.F., Watson, S.J. and Akil, H. : Loss of Glucocorticoid Fast Feedback in Depression. Archives of General Psychiatry 48:693-699, 1991.
33. Kwak, S.P., Young, E.A., Akil, H. and Watson, S.J. : Changes in proopiomelanocortin primary transcript levels in the anterior pituitary accompany increased ACTH secretion during the diurnal surge. Journal of Neuroendocrinology, 4:21-27, 1992.
34. Kwak, S.P., Young, E.A., Morano I., Watson, S.J. and Akil, H.: Diurnal corticotropin-releasing hormone messenger ribonucleic acid variation in the paraventricular nucleus exhibits a rhythm distinct from that of plasma corticosterone. Neuroendocrinology 55:74-83, 1992.
35 Herman JP, Cullinan WE, Young EA, Akil H, Watson SJ. Selective forebrain fiber tract lesions implicate ventral hippocampal structures in tonic regulation of paraventricular nucleus CRH and AVP mRNA expression. Brain Research 592:228-238, 1992.
36. Akil, H., Haskett, R.,Young, E.A., Grunhaus, L., Kotun, J., Weinberg, V., Greden, J., Watson, S.J.: Multiple HPA profiles in endogenous depression: Effect of age and sex on cortisol and beta- endorphin. Biological Psychiatry, 33:73-85, 1993.
37. Young, EA, Przewlocki, R., Patel, P. , Watson, S.J., Akil, H. Altered Ratios of β-Endorphin:β- Lipotropin Released from Anterior Lobe Corticotrophs with Increased Secretory Drive I: Effects of Diminished Glucocorticoid Secretion, J. Neuroendocrinology, 5:115-120, 1993.
38. Young, E.A., Day, R., Schafer, M.K., Watson, S.J., and Akil, H. Altered Ratios of β-Endorphin:β- Lipotropin Released from Anterior Lobe Corticotrophs with Increased Secretory Drive II: Repeated Stress, J. Neuroendocrinology, 5:121-126, 1993.
39. Young, E.A., Kotun, J., Haskett R.F., Grunhaus, L., Greden J.F., Watson S.J., Akil, H. Dissociation between Pituitary and Adrenal Suppression to Dexamethasone in Depression. Archives General Curriculum Vitae 11 Elizabeth Ann Young
Psychiatry 50: 395-403, 1993.
40. Kwak, SP, Morano IM, Young EA, Watson SJ, Akil H. The diurnal CRH mRNA rhythm in the hypothalamus: Decreased expression in the evening is not dependent on endogenous glucocorticoids. Neuroendocrinology 57:96-105, 1993
41. Young, EA, Bronstein D, Akil H. Dopaminergic Regulation of Swim Stress Induction of the Pituitary Intermediate Lobe POMC System. Neuroendocrinology, 58: 294-302, 1993.
42. Lieberzon I, Chalmers DT, Mansour A, Lopez JF, Watson SJ, Young EA Glucocorticoid regulation of hippocampal oxytocin receptor binding. Brain Research, 650:317-322, 1994.
43. Young, Elizabeth A. Roger F. Haskett, Leon Grunhaus, Atul Pande, Virginia Murphy Weinberg, Stanley J. Watson, Huda Akil. Increased Circadian Activation of the Hypothalamic Pituitary Adrenal Axis in Depressed Patients in the Evening . Archives General Psychiatry 51: 701-707, 1994.
44. . Young, EA, Akil, H, Haskett RF, and Watson SJ. Evidence Against Changes In Corticotroph CRF Receptors In Depressed Patients. Biological Psychiatry, 37: 355-363, 1995.
45. Young, EA. The glucocorticoid cascade hypothesis revisited: role of gonadal steroids, Depression, 3:20-27, 1995.
46. Young EA, Kwak SP, Kottak J. Negative feedback regulation following administration of chronic exogenous corticosterone J Neuroendocrinology 7: 37-45, 1995
47. Young EA Normal Glucocorticoid Fast Feedback Following Chronic 50% Corticosterone Pellet Treatment. Psychoneuroendocrinology, 20:771-784, 1995.
48. Young EA The role of gonadal steroids in Hypothalamic-pituitary-adrenal axis regulation, Critical Reviews in Neurobiology, 9:371-381, 1996
49. Young EA, Lopez JF, Murphy-Weinberg V, Watson SJ and Akil H. Normal Pituitary Response to Metyrapone in the Morning in Depressed Patients: Implications for Circadian Regulation of CRH Secretion, Biological Psychiatry, 41: 1149-1155, 1997.
50. Young, EA, Vazquez D. Hypercortisolemia, hippocampal glucocorticoid receptors and fast feedback. Molecular Psychiatry, 1:149-159, 1996.
51. Young EA Sex differences in response to exogenous corticosterone, Molecular Psychiatry, 1: 313- 319, 1996
52. Liberzon I, Krstov M., Young E.A. Stress-Restress: Effects on ACTH and Fast Feedback. Psychoneuroendocrinology, 22: 443-453, 1997.
53. Liberzon I, Young EA: Effects of Stress and Glucocorticoids on CNS Oxytocin Receptors binding Curriculum Vitae 12 Elizabeth Ann Young
Psychoneuroendocrinology, 22: 411-422, 1997.
54. Young EA James L. Abelson, George C. Curtis, and Randolph M. Nesse Childhood Adversity and Vulnerability to Mood and Anxiety Disorders, Depression and Anxiety 5: 66-72, 1997.
55. Liberzon I, Trujillo KA, Akil H, Young EA: Motivational properties of oxytocin in conditioned place preferance paradigm. Neuropsychopharmacology, 17: 353-359, 1997
56. Lieberman PB, Woods JH , Young EA: The Role of Endogenous Opioids in the LH Surge in Rats: Studies with Clocinnamox, a Long Lasting Opiate Antagonist, European Journal of Pharmacology, 352:73-79, 1998.
57. Young EA, Lopez JF, Murphy-Weinberg V, Watson SJ, Akil H. The Role of Mineralocorticoid Receptors in HPA Axis Regulation in Humans. Journal of Clinical Endocrinology and Metabolism, 83: 3339-3345, 1998
58. López JF, Liberzon I, Vázquez DM,Young EA and Watson SJ: Serotonin 1a receptor mRNA regulation in the hippocampus after acute stress. Biological Psychiatry 45:943-947, 1999.
59. Young EA, Nesse RM, Weder A, Julius S. Trait anxiety and cardiovascular reactivity: studies from the Tecumseh populatiion, Journal Hypertension, 16:1727-1733, 1998.
60. Young, EA. Sex Differences And The HPA Axis: Implications For Psychiatric Disease. Journal of Gender Specific Medicine, 1:21-27, 1998
61 Cyranowski, JM, Frank E, Young E, Shear MK. Adolescent onset of the gender difference in lifetime rates of major depression: a theoretical model, Archives of General Psychiatry, January 2000
62 Crofford LJ, Jacobson J and Young EA. Modeling the involvement of the hypothalamic-pituitary- adrenal and hypothalamic-pituitary-gonadal axes in autoimmune and stress-related rheumatic syndromes in women. Journal of Women’s Health 8:203-215, 1999
63 Liberzon I, Abelson JL, Flagel SB, Raz, J and young EA. Neuroendocrine and psychophysiological responses in PTSD: A symptom provocation study. Neuropsychopharmacology 21:40-50, 1999.
64 Liberzon I, Lopez JF, Flagel SB, Vazquez DM and Young EA. Differential regulation of hippocampal glucocorticoid receptors and negative feedaback: Relevance to PTSD. Journal of Neuroendocrinology 83:3339-3345. 1999
65 Young, EA., Lopez, JF., Murphy-Weinberg, V., Watson, SJ., and Akil.H. Hormonal Evidence for Altered Responsiveness to Social Stress in Major Depression, Neuropsychopharmacology, 23:411- 418, 2000
66 Young EA, Aggen SH, Prescott CA, Kendler KS. Similarity in saliva cortisol measures in monozygotic twins and the influence of past major depression. Biological Psychiatry, 48:70-74, 2000 Curriculum Vitae 13 Elizabeth Ann Young
67 Korszun AK, Young EA, Engelberg NC, Masterson L, Dawson EC, Spindler K, McClure LA, Brown MB, Crofford LJ. Follicular phase Hypothalamic-Pituitary-Gonadal axis function in women with fibromyalgia and chronic fatigue syndrome, J Rheumatology, 27:1526-30, 2000.
68 Young EA, Midgley AR, Carlson NE, Brown MB. Alteration in the Hypothalamic-Pituitary- Ovarian axis in depressed women. Archives of General Psychiatry, in press.
69 Young EA, Carlson NE, Brown MB. 24 Hour ACTH and Cortisol Pulsatility in Depressed Women, Neuropsychpoharmacology, under revision
70 Korszun A, Young, EA, Engelberg, NC, Crofford LJ, Greden JF. Fibromyalgia patients with comorbid depression exhibit decreased daytime activity and more disturbed sleep than patients with uncomplicated fibromyalgia, submitted J. Rheumatology
71 Young EA and Nolen-Hoeksema S. Effect of Ruminations on Saliva Cortisol Response to a Social stressor. Psychoneuroendocrinology, under revision.
Chapte rs, Reviews, And Meeting Proceedings:
1. Pariser, S.F., Pinta, E.R., Jones, B.A., and Young, E.A.: Anxiety states: Diagnosis and treatment. In: Psychopharmacology Update. J. Davis and M. Greenblatt, eds., Grune and Stratton, New York, 1979.
2. Akil, H., Watson, S.J., Young, E.A., Lewis, M.E., Khachaturian, H., and Walker, J.M.: Endogenous opioids: Biology and function. In: Annual Review of Neuroscience, Vol. 7. W.M., Cowan, ed., Annual Reviews, Inc., Palo Alto, 1984.
3. Watson, S.J., Akil, H., Khachaturian, H., Young, E.A., and Lewis, M.E.: Opioid systems: Anatomical, physiological, and clinical perspectives. In: Opioids: Past, Present, and Future. H.O.J. Collier, J. Hughes, M.J. Rance, and M.B. Tyers, eds., Taylor and Francis Limited, London, 1984, pp. 145-178.
4. Young, E.A., Watson, S.J., and Akil, H.: Pituitary regulation in endogenous depression. In: Psychiatric Disorders: Neurotransmitters and Neuropeptides. Progress in Brain Research, Vol. 65. J.M. van Ree and S. Matthysse, eds., Elsevier Press, 1986, pp. 153-166.
5. Akil, H., Young, E.A., Walker, J.M., and Watson, S.J.: The many possible roles of opioid and related peptides in stress induced analgesia. In: Annals of New York Academy of Sciences, Vol. 467. D.D. Kelly, ed., 1986, pp. 140-153.
6. Young, E.A., Watson, S.J., and Akil, H.: Peptides and psychiatry update: HPA axis regulation in depression. In: Brain Peptides Update, Vol. I. J.B. Martin, M.J. Brownstein, and D. Krieger, eds., John Wiley and Sons, Inc., 1987, pp. 231-238.
7. Watson, S.J., Akil, H., and Young, E.A.: Hypothalamo-Pituitary-Adrenal axis peptides in Curriculum Vitae 14 Elizabeth Ann Young
affective disease: Focus on the ACTH/beta-endorphin system. In: Handbook of Clinical Psychoneuroendocrinology. C.B. Nemeroff and P.T. Loosen, eds., in press.
8. Akil, H., Young, E.A., Watson, S.J.: Proopiomelanocortin peptide secretion from anterior and intermediate lobe: Effect of pre-translational and post-translational events. In: The Alfred Benzon Symposium on Molecular Mechanisms in Secretion Proceedings. Edited by Munksgaard, Denmark; Raven Press, U.S.A.; and Nancodo, Japan, in press.
9. Spencer RL, Miller AW, Young EA, and McEwen BS.: Stress induced changes in the brain: implications for aging In: Stress and Aging Brain, Eds. G Nappi et al, Raven Press, 1990.
10. Young, EA Endogenous Opioid Peptides and neuroendocrine regulation. In-Service Training and continuing education of American Association for Clinical Chemistry, Endocrinology and Metabolism.
11. Lopez JF, Young, EA, Herman JP, Akil H, and Watson SJ.: The regulatory Biology of the HPA axis: an integrative approach. In CNS Peptide Mechanisms Ed. S C. Risch, APA press, pp1-52, 1990.
12. Patel, P.D., Kwak, S.P., Herman, J.P., Young, E.A., Akil, H. and Watson, S.J.: Functional heterogeneity of type I and type II corticosteroid receptor expression in rat hippocampus. Procceding of the International Symposium on Stress and Reproduction, 1991.
13. Young E.A. ,Bronstein D.M and Akil H.: Proopiomelanocortin Biosynthesis, Processing, and Secretion: Functional Implications. Handbook of Experimental Pharmacology /Opioids I Ed.: A Herz, Vol 104/I, pp 393-421, 1993. Springer Verlag, Berlin Heidelberg, Germany.
14. Midgley AR, Brand RM, Favreau PA, Boving BG, Ghazzi MN, Padmanabhan V, Young EA and Cantor HC Monitoring dynamic responses of perifused neuroendocrine tissues to stimuli in real time. Quantitave Neuroendocrinology, Johannes Veldhuis editor, 1994.
15. Young EA. Stress and Reproductive Hormones. Infertility and Reproductive Medicine Clinics of North America 7: 227-242, 1996.
61. Young EA and Korszun A. Psychoneuroendocrinology of Depression: Hypothalamic-Pituitary Gonadal Axis, Psychiatric Clinics of North America, June 1998 pp 309-323. Editor CB Nemeroff. WB Saunders, Philadelphia PA 19106.
62. Frank, E and Young E. Pubertal changes and adolescent challenges: why do rates of depression rise precipitously for girls between ages 10 and 15 years? In Gender and Its Effects on Psychopathology, Ed Ellen Frank. American Psychiatric Press, Washington DC, 2000
63. Young, EA and Korszun A. Women, Stress and Depression: sex differences in hypothalamic- pituitary-adrenal axis regulation. In Gender Differences in Mood and Anxiety Disorders, From Bench to Bedside. Ed Ellen Leibenluft. American Psychiatric Press, Washington DC, 1999 Curriculum Vitae 15 Elizabeth Ann Young
64. Young, EA. DHEA: Mood , memory and aging. Editorial. Biological Psychiatry. 45: 1531, 1999
65. Young, EA . Metyrapone ; in Encyclopedia of Stress, G. Fink Editor Academic Press, in press
66. Young, EA, Altemus M and Korszun, A. Sex differences in neurohormone and neurotransmitter systems. In Handbook of Women’s Health, Susan Kornstein, Editor, in press
67. Young EA, and Liberzon, I. “Stress and Anxiety Disorders”, in Hormones, Brain and Behavior Donald Pfaff, editor
Abstracts, Preliminary Communications
1. Young, E.A., Lewis, J., Liebeskind, J. and Akil, H.: The effects of hypophysectomy on multiple opiate receptors. Presented at at the Annual Meeting of the Society for Neuroscience, Los Angeles, California, October, 1981.
2. Young, E.A., Olney, J. and Akil, H.: Delta, but not mu receptors increase in the thalamus of MSG- treated rats. Presented at the International Narcotic Research Conference, North Falmouth, Massachusetts, June, 1982.
3. Young, E.A, Woods, J. and Akil, H. UM 1071 binding in rat and guinea pig brain: The effects of alkaloids and endogenous opiate ligands. Presented at the Annual Meeting of the Society for Neuroscience, Minneapolis, Minnesota, November, 1982
4. Akil, H. Matthews, J., Shiomi, H., Young, E.A., Lin, H-L., Watson, S.J. Induction of intermediate lobe POMC biosynthesis, processing, and release. Presented at the International Narcotic Research Conference, Garmisch, West Germany, June, 1983.
5. Young, E.A., Walker, J.M., Houghten, R., andAkil, H. [3H] Dynorphin binding in brain. Presented at the International Narcotics Research Conference, Garmisch, West Germany, June, 1983.
6. Young, E.A., Watson, S. J., and Akil, H. CRF-induced ACTH/β-END release in stress. Presented at the Annual Meeting of the Society for Neuroscience, Boston, Massachusetts, November, 1983.
7. Walker, J.M. , Young, E.A., Coy, D.H., and Akil, H. Analgesic effects and binding properties of a flourinated analog of dynorphin (1-13). Presented at the Annual Meeting of the Society for Neuroscience, Boston, Massachusetts, November, 1983.
8. Akil, H., Young, E.A., and Watson, S.J.: Multiple opioids from the same precursor: Which is the real product? Presented at the International Narcotics Research Conference, Cambridge, England, July, 1984.
9. Young, E.A., and Akil, H.: Alterations in pituitary sensitivity to corticosteroids in chronically stressed rats. Presented at the International Narcotics Research Conference, Cambridge, England, July, 1984. Curriculum Vitae 16 Elizabeth Ann Young
10. Young, E.A. and Akil, H.: Alterations in pituitary sensitivity to corticosteroids in chronically stressed rats. Presented at the Annual Meeting of the Society for Neurscience, Anaheim, California, November, 1984.
11. Lopez, J.F., Watson, S.J., Young, E.A., Knobloch, M., Weinberg, G., Vale, W., Rivier, J., Greden, J., and Akil, H.: CRF releases β-endorphin/ β-LPH in normal humans. Presented at the Annual Meeting of the Society for Neurscience, Anaheim, California, November, 1984.
12. Young, E.A., Akil, H.: Changes in releasability of ACTH/β-endorphin with stress. Presented at the Annual Meeting of Society of Biological Psychiatry, Dallas, May, 1985.
13. Young, E.A., Walker, J.M., Houghten, J.M., and Akil, H.: The breakdown of [3H] dynorphin A in vivo and in vitro. Presented at the International Narcotics Research Conference, North Falmouth, Massachusetts, June, 1985.
14. Young, E.A., and Akil,H. Multiple products derived from opioid peptides. Presented at the Annual Meeting of the Society for Neurscience, Dallas, Texas, October, 1985.
15. Young, E.A., Akil, H. Changes in glucocorticoid negative feedback to the pituitary with chronic stress. Presented at the Annual Meeting of American College of Neuropsychopharmacology, Maui, Hawaii, December, 1985
16. Young, E.A., Akil, H., Kotun, J., Haskett, R.F., Greden, J.F., Rivier, J.,Vale, W., Watson, S.J.: Response to oCRF in normal controls and endogenous depression. Presented at the Annual Meeting of Society of Biological Psychiatry, Washington D.C., May, 1986
17. Young, E.A. and Akil, H.: Conversion of b-endorphin to g-endorphin in rat plasma.Presented at the International Narcotics Research Conference, San Francisco, July, 1986.
18. Robinson, T.E., Becker, J.B., Young, E.A., Akil, H. and Casteneda, E.:Neural and endocrine responses to footshock stress in rats sensitized to amphetamine. Presented at the Annual Meeting of the Society for Neuroscience, Washington, D.C., November, 1986.
19. Young, E.A., Dallman, M.F., and Akil, H.: Brain and pituitary glucocorticoid feedback in chronic stress. Presented at the Annual Meeting of the Society for Neuroscience, Washington, D.C., November, 1986.
20. Young, E.A., and Akil, H.: The role of adrenergic input in the induction of the intermediate lobe by chronic swim stress. Presented at the Annual Meeting of American College of Neuropsychopharmacology Washington, D.C., December 1986.
21. Kotun, J., Haskett, R., Young, E., Grunhaus, L., Knobloch, M., Watson, S.J., and Akil, H.: Beta- endorphin in depressive disorders--variations with time of day and severity. Presented at the Annual Meeting of Society of Biological Psychiatry, Chicago, May, 1987.
22. Young, E.A. and Akil, H.: Positive glucocorticoid feedback in chronic stress. Presented at the Curriculum Vitae 17 Elizabeth Ann Young
Annual Meeting of Society of Biological Psychiatry, Chicago, May, 1987.
23. Young, E.A. and Akil, H.: Acute stress and chronic stress release different forms of ß-END-IR from anterior lobe. Presented at the Society for Neuroscience, New Orleans, November, 1987.
24. Schäfer, M.K.-H., Herman, J.P., Young, E., Thompson, R., Douglass, J., Sherman, T.G., Akil, H., and Watson, S.J.: Gene expression of neuropeptides related to CRF after adrenalectomy. Presented at the Society for Neuroscience, New Orleans, November, 1987.
25. Meador-Woodruff, J.H., Young, E.A., Ling, N., and Akil, H.: Stress-Induced alterations of gamma-melanotropin in the rat pituitary. Presented at the Society for Neuroscience, New Orleans, November, 1987.
26. Young, E.A. and Akil, H.: Dopaminergic regulation of stress induced release from intermediate lobe. Presented at the Meeting of the American College of Neuropsychopharmacology, San Juan, Puerto Rico, December, 1987.
27. Young, E.A., Akil, H., and Haskett, R.F.: Glucocorticoid fast feedback in depression. Presented at the Annual Meeting of Society of Biological Psychiatry, Montreal, May, 1988.
28. Young, E. and Akil, H.: Mechanisms of stress-driven induction of the intermediate lobe. Presented at the International Narcotics Research Conference, Albi, France, July, 1988.
29. Young, E.A., Schafer, M.K., Herman, J.P., Day, R., Watson, S.J., and Akil, H.: Effects of ECT on the HPA axis: basic and clinical studies. Presented at the Annual Meeting of Society for Neuroscience, Toronto, November, 1988.
30. Kwak, S.P., Young, E.A., Przewlocki, R., Akil,H., and Watson, S.J. Effects of chemical adrenalectomy on vasopressin, CRF, and POMC mRNA regulation in the hypothalamus and pituitary. Presented at the Annual Meeting of Society for Neuroscience, Toronto, November, 1988.
31. Young, E. A., Akil, H., Grunhaus, L., Haskett, R.F., Watson, S.J. : Heterogeneity in the β-endorphin response to ECT. Presented at the Annual Meeting of Society of Biological Psychiatry, San Francisco, May, 1989.
32. Young E. A., Watson, S.J., Kwak, S.P., Patel, P. and Akil, H. : Adrenalectomy and metyrapone changes ratios of β-LPH:β-endorphin released from corticotrophs in vivo and in vitro. Presented at the Annual Meeting of The Endocrine Society, Seattle, June, 1989.
33. Young E. A., Bronstein, D., and H. Akil: Do haloperidol and swim stress act through a common mechanism? Presented at the Annual Meeting of Society for Neuroscience, Phoenix, 1989.
34. Young, E.A., Haskett, R.F., Akil, H., Watson, S.J. Evidence for increased CRF drive in the evening in depressed patients. Presented at the Annual Meeting of Society of Biological Psychiatry, New Curriculum Vitae 18 Elizabeth Ann Young
York, May, 1990.
35. Young, E.A., Haskett, R.F., Watson, S.J. and Akil, H. Glucocorticoid Fast Feedback in Depressed Subjects. Presented at 2nd International Congress of Neuroendocrinology, Bordeaux, France, June 1990.
36. Young, E.A., Kwak S., Watson, S.J., and Akil, H. Biphasic corticotroph secretion response to short term metyrapone. Presented at the Annual Meeting of Society for Neuroscience, St Louis, November, 1990.
37. Young, E.A., Kotun, J.F., Haskett, R.F., Grunhaus, L., Akil, H., and Watson, S.J. β-lipotropin/β- endorphin and cortisol nonsuppression to dexamethasone in depression: relationship to sampling time and dexamethasone levels. Annual Meeting of Society for Biological Psychiatry, May, 1991.
38. Young, E.A.: Glucocorticoid supplementation, hypothalamic -pituitary-adrenal (HPA) axis regulation and glucocorticoid receptors. Society for Neuroscience Annual Meeting, November, 1991.
39 Young, EA, Haskett RF, Akil, H. Watson, SJ. Influence of Gonadal Steroids and Menopausal Status on HPA Axis Regulation in Depression. Annual Meeting of Society for Biological Psychiatry, May, 1992
40 Young, EA Rat Brain Glucocorticoid Receptors Are Differentially Affected by Pattern of Chronic Corticosterone Administration E. A. Young, Abstracts of the Endocrine Society Annual Meeting, June, 1992.
41. Blockade of Cortisol Response by Metyrapone Administration Normalizes the Response to ovine Corticotropin Releasing Hormone in Depressed Patients. Elizabeth A. Young, Huda Akil, Roger F. Haskett, and Stanley J. Watson. Annual Meeting of The International Society for Psychoneuroendocrinology, August 1992.
42. Evidence Against Changes In Corticotroph CRH Receptors In Depressed Patients. Elizabeth A. Young*, Huda Akil, Roger F. Haskett, and Stanley J. Watson. Annual Meeting The Society for Neuroscience, October 1992, Annaheim, CA.
43. Brain Glucocorticoid Receptors Are Differentially Affected By The Pattern Of Chronic Corticosterone Administration. E. A. Young, S.P. Kwak, S. J. Watson. Annual Meeting Society for Biological Psychiatry, May 1993, San Francisco, CA.
44. Glucorticoid Regulation Of Oxytocin Binding In Rat Hippocampus. Israel Liberzon, Derek Chalmers, Stanley J. Watson, Elizabeth Young, Annual Meeting Society for Biological Psychiatry, May 1993, San Francisco, CA.
45. 50% Corticosterone Pellet treatment does not affect fast feedback. EA Young, K Fried, E Ho. Annual Meeting The Society for Neuroscience, November, 1993, Washington DC.
46. Constant versus phasic corticosterone administration have different effects on brain glucocorticoid receptors and fast feedback sensitivity, ACNP, Dec 1993, Honolulu. Curriculum Vitae 19 Elizabeth Ann Young
47. Normal Response To Morning Metyrapone Administration In Depressed Patients E.A. Young, V. Murphy-Weinberg, J.F. Lopez, S.J. Watson, H. Akil, Society for Biological Psychiatry, May 1994
48. Ovarian steroids antagonize glucocorticoid effects on HPA axis. Society of Biological Psychiaty, May 1995, Miami, FL.
49. CNS Oxytocin Binding: Effects of stress and glucocorticoids. I Liberzon, EA Young. Society of Biological Psychiaty, May 1995, Miami, FL.
50. Delayed and non-habituating stress: effects on ACTH and corticosterone response to restress. I Liberzon, KM Hafer and EA Young, Annual Meeting The Society for Neuroscience, November, 1995, San Diego
51. Is a decrease in opioid tone necessary for the timing of the LH surge in rats? PB Lieberman, CA Paronis, JH Woods, EA Young. Annual Meeting The Society for Neuroscience, November, 1995, San Diego
52. Analytic Methods in Neuroendocrine research, EA Young, ACNP study panel, December, 1995.
53. Stress-restress: an animal model of PTSD. I Liberzon, M Krstov, EA Young . Society of Biological Psychiaty, May 1996, New York
54. Oxytocin's effects on AMPA receptor mRNA in Hippocampus. M Karam-Hage, I Liberzon, KA Bovenkirk, EA Young, JH Meador-Woodruff, Society of Biological Psychiaty, May 1996, New York.
55. Young EA, Ovarian hormones and the regulation of stress systems, Symposium talk presented at The International Psychoneuroendocrinology Meetings, August 1997 in San Francisco CA.
56. Young EA. Pulsatile and Circadian analyses of the HPA axis in Depressed women, Abstract presented at the Society of Biological Psychiatry Annual Meeting May 1998.
57. Young, EA Sex Differences in Response to Glucocorticoid Inhibition of Stress Responsiveness, American Neuroendocrine Stress Meeting, New Orleans, June 1998
58. Young EA Ovarian hormones and the regulation of stress systems, Abstract presented at The Second World Congress on Stress, Melbourne Australia, October 1998.
59. Young, EA Pulsatile analyses of reproductive hormones in depressed women. Abstract presented at the Society for Biological Psychiatry, May 1999
60. Young EA Ovarian Hormones And The Regulation Of Stress Systems, Abstract Presented at APA, May 1999.
61. Young EA, Altemus M, Parkison V, Shastry S. Effect of Estradiol on sensitivity to glucocorticoid feedback in females, Presented at Society for Neuroscience, , November 1999
71. Young EA, Lopez JF, Weinberg V,Watson SJ and Akil H. Altered Hormonal Response To A Social Stressor In Major Depression, Presented at Society for Biological Psychiatry, May 2000 Curriculum Vitae 20 Elizabeth Ann Young
72 Young, EA, Altemus, M. Gender Differences In The Regulation Of The Hypothalamic-Pituitary Adrenal Axis, Presented at the Second International Conference on Hormones, Brain and Neuropharmacology, July 2000.