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January 2016 QuarterlyBrain & Behavior Research Foundation January 2016 PRESENTING THE DISTINGUISHED INVESTIGATORS Interview with a Researcher Advice on Caring for Bipolar Disorder A RECOVERY STORY: HUDA AKIL, PH.D. with ROBERT M.A. HIRSCHFELD, M.D. From A Nightmare Childhood, A Happy Path Forward bbrfoundation.org BY THE NUMBERS SINCE 1987 Awarded to Scientists $342 MILLION Grants The breakdown of our grantees since 1987 3,888 Young Investigators 748 Independent Investigators 5,000+ 394 Distinguished Investigators Universities & Countries, Medical Centers Including the U.S. 529 34 165 Scientific Council Members The all-volunteer The group includes: Foundation Scientific Council 52 Members of the Institute of Medicine is composed of 165 leading experts 23 Chairs of Psychiatry & Neuroscience Departments across disciplines in brain & behavior research 13 Members of the National Academy of Sciences who review grant applications and 4 Recipients of the National Medal of Science recommend the 4 Former Directors of the National Institute of Mental Health most promising ideas to fund. 2 Nobel Prize Winners Board of Directors OFFICERS Contents Chairman Stephen A. Lieber Vice President Suzanne Golden Secretary President’s Letter . 3 John B. Hollister Drs . Betty and David Hamburg Receive Treasurer Arthur Radin, CPA Pardes Humanitarian Prize Honors . 4 Interview with a Researcher: Huda Akil, Ph .D . DIRECTORS Anne E. Abramson The Biology of Emotions . 6 Donald M. Boardman J. Anthony Boeckh Ask the Researcher: Nora Volkow, M .D . 9 Susan Lasker Brody Paul T. Burke Research Discoveries in the News . 10 Bonnie D. Hammerschlag John Kennedy Harrison II Highlights from the 2015 New York Mental Health Carole H. Mallement Research Symposium . 13 Milton Maltz Marc R. Rappaport FEATURE: 2015 Distinguished Investigator Grants . 21 Virginia M. Silver Kenneth H. Sonnenfeld, Ph.D., J.D. Frequently Asked Questions . 27 Barbara K. Streicker Barbara Toll FEATURE: Parenting: Advice on Caring for Bipolar Disorder, Robert Weisman, Esq. A Conversation with Robert M .A . Hirschfeld, M .D . 29 EX-OFFICIO FEATURE: A Recovery Story: From A Nightmare Childhood, President & CEO A Happy Path Forward . 34 Jeffrey Borenstein, M.D. President, Scientific Council Glossary . 36 Herbert Pardes, M.D. President Emerita Constance E. Lieber PUBLICATION CREDITS Writers Fatima Bhojani Elena Gooray Becky Ham Jennifer Michalowski Peter Tarr, Ph.D. Editors Lauren Duran Becky Ham Design Cover Credit: Photo of Catherine Dulac Courtesy of the Department of Molecular and Kim Howie Cellular Biology, Harvard University bbrfoundation.org 1 Scientific Council 165 Members 2 Nobel Prize Winners 4 Former Directors of the National Institute of Mental Health PRESIDENT 4 Recipients of the National Medal of Science Herbert Pardes, M.D. 13 Members of the National Academy of Sciences 21 Chairs of Psychiatry & Neuroscience Departments at VICE PRESIDENT EMERITUS Leading Medical Institutions Floyd E. Bloom, M.D. 47 Members of the Institute of Medicine Ted Abel, Ph.D. Frederick K. Goodwin, M.D. Richard J. Miller, Ph.D. Anissa Abi-Dargham, M.D. Joshua A. Gordon, M.D., Ph.D. Karoly Mirnics, M.D., Ph.D. George K. Aghajanian, M.D. Elizabeth Gould, Ph.D. Bita Moghaddam, Ph.D. Schahram Akbarian, M.D., Ph.D. Anthony A. Grace, Ph.D. Dennis L. Murphy, M.D. Huda Akil, Ph.D. Paul Greengard, Ph.D. Charles B. Nemeroff, M.D., Ph.D. Susan G. Amara, Ph.D. Raquel Gur, M.D., Ph.D. Eric J. Nestler, M.D., Ph.D. Stewart A. Anderson, M.D. Suzanne N. Haber, Ph.D. Andrew A. Nierenberg, M.D. Nancy C. Andreasen, M.D., Ph.D. Philip D. Harvey, Ph.D. Patricio O’Donnell, M.D., Ph.D. Amy F.T. Arnsten, Ph.D. Stephan Heckers, M.D. Dost Ongur, M.D., Ph.D. Gary S. Aston-Jones, Ph.D. Nathaniel Heintz, Ph.D. Steven M. Paul, M.D. Jay M. Baraban, M.D., Ph.D. René Hen, Ph.D. Godfrey D. Pearlson, MBBS, M.D. Deanna Barch, Ph.D. Fritz A. Henn, M.D., Ph.D. Marina Piciotto, Ph.D. Jack D. Barchas, M.D. Takao Hensch, Ph.D. Daniel S. Pine, M.D. Samuel H. Barondes, M.D. Robert M.A. Hirschfeld, M.D. Robert M. Post, M.D. Francine M. Benes, M.D., Ph.D. L. Elliot Hong, M.D. James B. Potash, M.D., M.P.H. Karen F. Berman, M.D. Steven E. Hyman, M.D. Steven G. Potkin, M.D. Wade H. Berrettini, M.D., Ph.D. Robert B. Innis, M.D., Ph.D. Pasko Rakic, M.D., Ph.D. Randy D. Blakely, Ph.D. Jonathan A. Javitch, M.D., Ph.D. Judith L. Rapoport, M.D. Pierre Blier, M.D., Ph.D. Daniel C. Javitt, M.D., Ph.D. Perry F. Renshaw, M.D., Ph.D., M.B.A. Robert W. Buchanan, M.D. Lewis L. Judd, M.D. Kerry J. Ressler, M.D., Ph.D. Peter F. Buckley, M.D. Peter W. Kalivas, Ph.D. Carolyn B. Robinowitz, M.D. William E. Bunney, Jr., M.D. Eric R. Kandel, M.D. Bryan L. Roth, M.D., Ph.D. Joseph D. Buxbaum, Ph.D. Richard S.E. Keefe, Ph.D. John L.R. Rubenstein, M.D., Ph.D. William Byerley, M.D. Samuel J. Keith, M.D. Bernardo Sabatini, M.D., Ph.D. Marc G. Caron, Ph.D. Martin B. Keller, M.D. Gerard Sanacora, M.D., Ph.D. William T. Carpenter, Jr., M.D. John R. Kelsoe, M.D. Akira Sawa, M.D., Ph.D. Cameron S. Carter, M.D. Kenneth S. Kendler, M.D. Alan F. Schatzberg, M.D. BJ Casey, Ph.D. James L. Kennedy, M.D. Nina R. Schooler, Ph.D. Dennis S. Charney, M.D. Robert M. Kessler, M.D. Robert Schwarcz, Ph.D. Bruce M. Cohen, M.D., Ph.D. Kenneth K. Kidd, Ph.D. Philip Seeman, M.D., Ph.D. Jonathan D. Cohen, M.D., Ph.D. Mary-Claire King, Ph.D. Yvette I. Sheline, M.D. Peter Jeffrey Conn, Ph.D. Rachel G. Klein, Ph.D. Pamela Sklar, M.D., Ph.D. Edwin Cook, M.D. John H. Krystal, M.D. Solomon H. Snyder, M.D., DSc, D.Phil. Richard Coppola, DSc Amanda Law, Ph.D. (Hon. Causa) Joseph T. Coyle, M.D. James F. Leckman, M.D. Matthew State, M.D. Jacqueline N. Crawley, Ph.D. Francis S. Lee, M.D., Ph.D. Murray Stein, M.D., M.P.H. John G. Csernansky, M.D. Ellen Leibenluft, M.D. John S. Strauss, M.D. Karl Deisseroth, M.D., Ph.D. Robert H. Lenox, M.D. J. David Sweatt, Ph.D. J. Raymond DePaulo, Jr., M.D. Pat Levitt, Ph.D. John A. Talbott, M.D. Ariel Y. Deutch, Ph.D. David A. Lewis, M.D. Carol A. Tamminga, M.D. Wayne C. Drevets, M.D. Jeffrey A. Lieberman, M.D. Laurence H. Tecott, M.D., Ph.D. Ronald S. Duman, Ph.D. Irwin Lucki, Ph.D. Ming T. Tsuang, M.D., Ph.D., DSc Jan A. Fawcett, M.D. Gary Lynch, Ph.D. Leslie G. Ungerleider, Ph.D. Stan B. Floresco, Ph.D. Robert C. Malenka, M.D., Ph.D. Rita J. Valentino, Ph.D. Judith M. Ford, Ph.D. Anil K. Malhotra, M.D. Jim van Os, M.D., Ph.D., MRCPsych Alan Frazer, Ph.D. Husseini K. Manji, M.D., FRCPC Susan Voglmaier, M.D., Ph.D. Robert R. Freedman, M.D. J. John Mann, M.D. Nora D. Volkow, M.D. Fred H. Gage, Ph.D. John S. March, M.D., M.P.H. Mark von Zastrow, M.D., Ph.D. Aurelio Galli, Ph.D. Helen S. Mayberg, M.D. Karen Dineen Wagner, M.D., Ph.D. Mark S. George, M.D. Robert W. McCarley, M.D. Daniel R. Weinberger, M.D. Elliot S. Gershon, M.D. Bruce S. McEwen, Ph.D. Myrna M. Weissman, Ph.D. Mark A. Geyer, Ph.D. Ronald D.G. McKay, Ph.D. Jared W. Young, Ph.D. Jay N. Giedd, M.D. James H. Meador-Woodruff, M.D. L. Trevor Young, M.D., Ph.D. Jay A. Gingrich, M.D., Ph.D. Herbert Y. Meltzer, M.D. Jon-Kar Zubieta, M.D., Ph.D. David Goldman, M.D. Kathleen Merikangas, Ph.D. 2 Quarterly January 2015 bbrfoundation.org 2 PRESIDENT’S LETTER Jeffrey Borenstein, M .D . President & CEO Brain & Behavior Research Foundation I recently had the honor of representing the Brain & Behavior This issue of the Quarterly highlights the 15 exceptionally Research Foundation at an event at the U.S. Supreme Court talented winners of our 2015 Distinguished Investigator honoring Judge Steven Leifman of Miami, Dade County, Grants, which provide $100,000 to senior scientists who Florida. Judge Leifman, who received our Foundation’s have a cutting edge and innovative idea which requires Productive Lives Award in 2012, received the William H. seed money to gather data so as to gain additional fund- Rehnquist Award from Supreme Court Chief Justice John ing. We offer advice on caring for people with bipolar Roberts. This award is one of the nation’s highest judicial disorder from preeminent psychiatrist and member of our honors and is presented to a state court judge “who exem- Scientific Council, Dr. Robert Hirschfeld and feature an plifies judicial excellence, integrity, fairness and professional interview with Dr. Huda Akil, also a Scientific Council ethics.” Judge Leifman was honored for his “transformative member and 2007 winner of the Goldman-Rakic Prize work in the way people with mental illness are treated in the for Outstanding Achievement in Cognitive Neuroscience criminal justice system.” on the biology of emotions. One of the saddest and most tragic aspects of mental illness We also report on our Annual New York Mental Health is when a person becomes involved in the criminal justice Research Symposium and our Annual National Awards system as a result of untreated or inadequately treated illness.
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