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Thompson, Ph.D CURRICULUM VITAE PERSONAL DATA Name: Robert Charles Thompson, Ph.D. Title: Research Associate Professor, Department of Psychiatry Research Associate Professor, Molecular and Behavioral Neuroscience Institute (MBNI) Program/Address: 5049 Biomedical Sciences Research Building 109 Zina Pitcher Place Ann Arbor, MI 48109-2200 Phone: (734) 615-3117 Fax: (734) 936-2690 E-mail: [email protected] EDUCATION AND TRAINING 9/74-6/78 Bachelor of Sciences in Biochemistry Juniata College, Huntingdon, Pennsylvania 9/84-9/6//85 Masters Program in Biology (M.S.) University of Oregon, Eugene, Oregon Edward Herbert, Ph.D. Mentor 9/85-6/09/89 Ph.D. Program Dept. of Cell Biology and Anatomy Vollum Institute for Advanced Biomedical Research Oregon Health Sciences University (O.H.S.U.) Portland, Oregon 97201 Edward Herbert. Ph.D./James O. Douglass, Ph.D., Mentors 8/88-5/95 Postdoctoral Fellow, University of Michigan, Mental Health Research Institute, Ann Arbor, Michigan Mentor: Stanley J. Watson, M.D., Ph.D. EMPLOYMENT 7/78-4/79 Electron Microscopist, Hershey Medical Center, Department of Pathology University of Pennsylvania School of Medicine, Hershey, PA. Javad Tofigi, M.D. Supervisor. 5/79-2/84 Research Asst II/Associate I, University of Michigan, Mental Health Research Institute, University of Michigan, Ann Arbor, MI. Stanley J. Watson, M.D., Ph.D. Supervisor ACADEMIC APPOINTMENTS 6/95-10/03 Assistant Research Scientist, Reproductive Sciences Program, University of Michigan, Ann Arbor, MI. 11/03-09/10 Research Assistant Professor, Reproductive Sciences Program, University of Michigan, Ann Arbor, MI. 06/99-04/01 Assistant Research Scientist, Department of Psychiatry, University of Michigan, Ann Arbor, MI. 05/01-06/08 Assistant Professor, Department of Psychiatry, University of Michigan, Ann Arbor, MI. 08/05-09/10 Research Assistant Professor, Molecular and Behavioral Neuroscience Institute. 1 Thompson, Robert C. January 2015 CV Thompson, R.C. 01/15 02/09-09/10 Research Assistant Professor, Department of Psychiatry, University of Michigan, Ann Arbor, MI. 09/10-07/12 Research Associate Professor, Reproductive Sciences Program, University of Michigan, Ann Arbor, MI. 09/10-present Research Associate Professor, Molecular and Behavioral Neuroscience Institute. 09/10-present Research Associate Professor, Department of Psychiatry, University of Michigan, Ann Arbor, MI. RESEARCH INTERESTS: 1. Determine the role of altered gene expression in brain regions that regulate mood and relate to psychiatry disease. 2. Determine the underlying mechanisms by which stress and endocrine challenges influence brain function. 3. Determine the roles of small non-coding RNAs in the adult brain and in psychiatric disease. GRANT SUPPORT Direct Term Effort Costs/year Current Pritzker Neuropsychiatric Research Consortium. Role: Co-Investigator, (Huda Akil, Stanley Watson, PIs). 9/07 – 6/14 5% $1,925,000 NIH R01 MH104261, entitled: Can Affective Resilience be Enhanced? A Developmental and Epigenetic Approach 07/01/14 – Role: Co-Investigator (PI: Akil/Watson) 06/30/19 8% $389,427 Grants Pending NIH R01 Prefrontal Cortical Interneurons and Stress Adaptation. MPI: (Herman, Submitted Thompson) June 2017 20% $275,000 NIH R21 Entitled: Identify Unannotated Transcripts in Human and Mouse Genomes. Submitted Co-PI (Meng, Thompson). Oct 2017 10% $275,000 NIH R21 –Entitled: Single Cell Transcriptomics to Map the Effects of Developmental Lead Exposure on the Submitted Hippocampus (Co-I) Oct 2017 6% GRANTS COMPLETED: NARSAD Independent Investigator Grant 09/15/13- 09/14/15 Role: Principal Investigator Title: Stress Dependent Regulation of the Transcriptome in Genetically Defined CNS Cell Types. 2 Thompson, Robert C. January 2015 CV Thompson, R.C. 01/15 This project aimed to identify gene differentially regulated by chronic variable stress in cortical astrocytes using a translational RNA affinity purification methodology to isolate RNA. R01 DA025973 09/08 – 06/13 Role Co-Principal Investigator (Stanley J. Watson, Co-PI). NIH/NIDA Title: Cocaine Regulation of miRNAs in Rats with Differing Vulnerability to Drug Abuse. This project aimed to identify microRNAs that varied between two lines of rodents bred for their differences in a novel environment as well as how these microRNAs varied due to cocaine exposure in both lines of rats. R21 MH090574-01 06/30/11 – 5/31/13 NIH/NIMH Title: Stress Regulation of Non-Coding RNAs in Prefrontal Cortex This project aims to identify microRNAs that are differentially expressed due to chronic stress treatments in mice. P01 DA021633 09/31/07 – 06/30/12 NIH NIDA Title: Antecedents and Consequences of Drug Abuse: Heritability, Stress and Neuroplasticity. This project aims to use selectively bred rat lines that vary in their propensity to self-administer drugs of abuse to detail the underlying neuroanatomical and molecular differences that underlie these traits. 1R21 MH083175-A2 (Thompson, Robert C, PI) 08/11/09 – 07/31/11 NIH / NIMH Title: microRNA Expression Patterns in Human Psychiatric CNS Samples This project aims to use miRNA-based microarrays to examine the patterns of miRNAs expressed in different human brain regions using sample derived from controls and major depressive disorder (MDD) patients. UM CCMB Pilot Research Grant Program (Thompson, Robert C and Meng, Fan; Co-PIs). 08/09 – 07/11 University of Michigan Center for Computational Medicine and Biology microRNA Expression Patterns in Human Bipolar CNS Samples This pilot research project aims to use deep sequencing strategies to profile microRNA expression using RNA samples derived from a limited number of control and Bipolar (BP) disorder patients. miRNA expression patterns will evaluated using miRNA in situ hybridization methods as well as compared to mRNA expression patterns derived from the same RNA samples (same patients, same brain regions). R01 MH069879 (Jeffery Tasker, PI, Univ of Tulane). Role: Co-I. 07/04 – 06/11 NIH/NIMH Title: Cellular Plasticity and HPA Axis Dysfunction. The major goal of this study was to utilized gene expression technologies to identify genes related to synaptic alterations following chronic stress. R01 NS051472 (Michael D. Uhler, PI). Role: Co-I 1/05 – 12/10. NIH/NS Title: Functional Genomic Studies of Neuronal Differentiation. Microarray identification of genes regulated during P19 neuronal differential followed by functional evaluation of a subset of these genes with conserved non-genic sequences (CNGs) using surface transfection and expression protocol (STEP) and RNAi technologies 3 Thompson, Robert C. January 2015 CV Thompson, R.C. 01/15 HONORS AND AWARDS 1989-1992 National Research Service Award 1996-1998 Young Investigator Award, National Alliance for Research on Schizophrenia and Depression 1999-2001 Young Investigator Award, National Alliance for Research on Schizophrenia and Depression 2005 Neuroscience Program Faculty Outstanding Service Recognition Award MEMBERSHIP IN PROFESSIONAL SOCIETIES Society For Neuroscience (1988- present) American Association For the Advancement of Science (1986- present) American Neuroendocrine Society (2003-present) Endocrine Society (2006-present) EDITORIAL POSITIONS, PEER-REVIEW SERVICE Journal Reviewer 1988-present American Journal of Physiology-Endocrinology and Metabolism Journal of Neuroscience Brain Research Chemical Neuroanatomy Endocrinology Endocrine Journal of Biological Chemistry Journal of Neurochemistry Molecular Endocrinology Molecular Psychiatry Physiological Genomics Proceedings of the National Academy of Sciences Grant Reviewer: NIH NIDA Special Emphasis Panel (Microarrays): ZDA1 RXL-E (20) 7/00 NIH NIAAA Special Emphasis Panel (Microarrays): ZAA1CC01 2/08/01 NIH NIAAA Biomedical Research Review Committee 2/14/02 NIH NIDA Center Grant Review (ZDA1 RSL-E(94), adhoc reviewer) 2/15/02 NIH NIDA Site Visit Team Member (ZDA1 RSL-E (94)) 4/16/02 -4/17/02 TEACHING ACTIVITIES Current Human Neuroanatomy (Med Adm 570, 2000-2009) Limbic System 2 hours Hypothalamus 2 hours Chemical Senses 2 hours Autonomic Nervous System 2 hours Psychiatry Residency Core Curriculum Proteolytic Processing of Neuropeptides. (1 hr; 1995) DNA chips and Psychiatric Disorders (1 hr; 1999)) Basic Molecular Biology Introduction (2001 – present) Neurotransmitters and Signal Transduction (2014-present) 4 Thompson, Robert C. January 2015 CV Thompson, R.C. 01/15 Introduction to Research in Cellular and Molecular Neurobiology (Neuroscience 623), 2006 through present. Worked with two other UM faculty to lead 2 week laboratory course. My responsibilities were to lead instruction on molecular biology and protein measurement methods. Research Responsibility and Ethics (PIBS 503; 2004 – present) Oversee discussion group Mammalian Reproductive Endocrinology (MRE 541, 1996-present). Molecular Biology of Reproduction I (Basic Molecular Methods, Transcriptional Regulation and Approaches). Molecular Biology of Reproduction II (Transcriptional Regulation, Receptors, Cellular Signaling) 10 hrs (1996), 8 hours (1997), 4 hours (1998-2001); 2 hours (2002-2008) Past Neuroanatomy, Oregon Health Sciences University, Winter term (1988) Instructor (1988). Course Director: Gary Ciment, Ph. D.Dept. of Cell Biology & Anatomy Morphology for Molecular Biologists, ACB 533 (1996 - 2000) Advanced In Situ Hybridization Strategies (2 hrs) Signaling in the Nervous System (Neuroscience 612; 2004 – 2007) 2 hour lecture on Opiates and Neuropeptides Research Training Summary Undergraduate Research 30 (2 for honors) Graduate Student Rotations 15 Medical Student Research Rotations 2 Predoctoral
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