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Drugs & Chemicals 1: Tumor Suppressor Protein p53 2: Heterogeneous-Nuclear Ribonucleo- (1029) proteins (14) activ apoptosi arf cell express function inactiv induc altern assai associ bind mdm2 mutat p53 p73 pathwai protein regul complex detect exon famili genom respons suppress suppressor tumor wild-typ interact intron isoform nuclear protein sensit site specif splice suggest variant 3: RNA, Transfer (110) 4: DNA Primers (1987) codon contain differ eukaryot gene initi amplifi analysi chain clone detect dna express mrna protein region ribosom rna fragment gene genotyp mutat pcr sequenc site speci suggest synthesi polymorph popul primer reaction region restrict sequenc speci termin translat trna utr 5: Saccharomyces cerevisiae Proteins 6: Apoptosis Regulatory Proteins (291) (733) activ apoptosi apoptosis-induc albican bud candida cerevisia complex encod apoptot bcl-2 caspas caspase-8 cell eukaryot fission function growth interact involv death fasl induc induct ligand methyl necrosi pathwai program sensit surviv trail mutant pomb protein requir saccharomyc strain suggest yeast 7: Plant Proteins (414) 8: Membrane Proteins (1608) access arabidopsi cultivar flower hybrid leaf leav apoptosi cell conserv domain express function gene human identifi inhibitor line maiz plant pollen rice root seed mammalian membran mice mous mutant seedl speci thaliana tomato transgen wheat mutat protein signal suggest transport 1 9: Tumor Suppressor Proteins (815) 10: 1-Phosphatidylinositol 3-Kinase activ arrest cell cycl cyclin damag delet dna (441) 3-kinas activ akt cell egf egfr express function gene methyl mutat p53 epiderm factor gefitinib inhibit inhibitor promot protein repair suppressor system growth kinas pathwai phosphoryl pi3k receptor tumor signal surviv tyrosin 11: Proteins (1227) 12: Enzyme Precursors (42) algorithm apoptosi avail cell data databas domain encod express function gene inform method mice mutat activ analysi cell differ evid express function increas kinas mechan phosphoryl protein network predict protein set structur provid role signal site specif structur suggest tyrosin 13: Caspase 1 (15) 14: Caspases (794) apoptosi associ cell control activ apoptosi apoptot bax bcl-2 caspas caspase-3 cell death induc induct death express famili gene inhibit inhibitor mechan pathwai proapoptot protein releas surviv trail increas induc level member mice mous mutant phenotyp rat respons role select 15: Cytochromes c (184) 16: Intracellular Signaling Peptides and Proteins (602) activ apoptosi apoptot bax bcl-2 caspas caspase-3 cell cytochrom death activ apoptosi cell death induc induct inhibitor mechan mitochondri mitochondria mtdna pathwai protein releas diseas express function gene induc interact kinas mechan mutat pathwai patient phosphoryl protein regul role signal 2 17: Frizzled Receptors (22) 18: Receptors, G-Protein-Coupled activ beta-catenin cell differ famili form format (175) identifi involv local mechan pathwai protein action activ agonist alpha antagonist beta cell express gamma gene glucocorticoid ligand mediat pathwai regul requir role sequenc signal receptor role signal stimul studi transduct wnt subunit 19: Macromolecular Substances (157) 20: Eye Proteins (215) cell conclusions cone degener develop activ assembl bind complex compon dna essenti form format function human examin express gene implant macular interact model process protein recruit requir site structur subunit methods mutat optic photoreceptor pigment protein retin retina studi visual 21: Drosophila Proteins (613) 22: Protein Kinase C (266) adult aphid conserv control differ activ c-jun cell erk increas induc inhibit drosophila fli fly function inhibitor jnk kinas mapk host insect larva larval mammalian melanogast mitogen-activ p38 pathwai mosquito pheromon speci suggest wing phosphoryl pkc protein regul signal stimul 23: DNA-Binding Proteins (3805) 24: Nerve Tissue Proteins (954) activ bind cell damag dna domain associ bind cell depress diseas disord express function gene genet express factor function gene identifi interact mechan mice motor mutat neuron progress protein studi mice mutat promot protein regul regulatori repair signal site transcript 3 25: Transcription Factors (3309) 26: Repressor Proteins (859) activ bind cell develop differenti element express activ cell chromatin control domain express factor function gene mutat pathwai factor function gene histon mutat pathwai promot regul regulatori repress role signal site transcript promot protein regul regulatori repress role signal transcript 27: DNA (2387) 28: Tumor Markers, Biological (1491) analysi cancer carcinoma clinic express allel analysi associ bind damag dna fragment gene genet genom genotyp mutat pcr factor gene lesion marker polymorph popul promot region repair replic sequenc outcom patient poor predict prognosi prognost specimen stage stain surviv tumor 29: Nitrates (54) 30: Organometallic Compounds (54) concentr demonstr differ effect group acid associ caus cell chang increas level model nitric oxid activ produc product rate reduc sampl studi suggest synthas combin complex compound water synthesi deriv effect group high increas model process select structur studi treatment 31: Lead (43) 32: Kinesin (65) caus dose effect expos cell centrosom chromosom exposur function genet group health increas irradi lead level method model develop divis express famili radiat respons sampl studi water function gene meiotic microtubul mitosi mitot protein requir respons segreg sequenc specif 4 spindl 33: Neutral Red (6) 34: Paclitaxel (309) advanc agent anticanc cancer assai caus cell concentr dai chemotherapi cisplatin combin cytotox detect determin dna effect evid exposur light method microm min rat drug effect median paclitaxel specif support test sensit patient phase regimen respons sensit surviv toxic treatment 35: Tubulin Modulators (5) 36: Tubulin (142) agent bind cancer data drug activ cell centrosom checkpoint estim exposur identifi effect chromosom cytokinesi divis inhibit larg method new reduc screen express increas local meiosi meiotic size small structur target therapi microtubul mitosi mitot protein requir segreg spindl studi 37: HLA Antigens (146) 38: Histocompatibility Antigens Class I (233) allel antigen associ class complex donor drb1 genet histocompat hla human leukocyt major allel antigen barrier class complex drb1 natur patient present transplant mhc molecul gap leukocyt type histocompat hla human iron junction major mhc molecul natur present specif type 39: Spectrin (22) 40: Factor IX (28) cell control decreas defici earli function adenoviru adult analysi deliveri develop differ effici express factor group human identifi increas gene growth human mechan molecular studi larg level local new number therapi transfer year observ protein rel sampl studi suggest vector 5 41: Hepatitis delta Antigens (3) 42: Calcium (528) affect analysi blot conserv detect dna activ atp bone ca2+ calcium cam cell express form format gene gener channel current function gate mammalian mutant protein region human intracellular ion potassium potenti receptor releas sodium subunit respons reveal sequenc vector western 43: Glycine (128) 44: Oxygen (281) acid activ analysi control diseas enzym function activ antioxid damag differ endotheli energi enzym free function increas level gene increas model mutant mutat patient polymorph posit residu site structur measur oxygen rate reactiv studi substitut oxid respons speci stress studi 45: Sulfatases (11) 46: Cysteine (166) detect develop chang cleavag cystein form function group human activ increas indic mutant mutat posit proteas protein enzym function gene genom residu role serin stabil structur high isol level low mutat product protein site site specif strain structur substrat tissu 47: Histones (546) 48: Histone Deacetylases (285) acetyl activ associ chromatin acetyl activ associ cbp chromatin coactiv deacetylas dna gene hdac coactiv deacetylas gene hdac histon histon mechan modif nucleosom mechan modif nucleosom p300 recruit regul p300 recruit regul remodel repress silenc remodel repress silenc transcript transcript 6 49: Sirtuins (40) 50: Lysine (199) acetyl activ chromatin cleavag degrad differ acetyl activ chromatin coactiv domain effect function gene histon increas combin deacetylas function hdac mutat proteas protein residu site histon mechan modif mutant specif structur transcript nucleosom recruit regul remodel repress role studi transcript 51: Silent Information Regulator Pro- 52: Phosphoglycerate Dehydrogenase teins, Saccharomyces cerevisiae (23) (1) acetyl activ assembl biosynthesi catalyt acetyl activ chromatin complex control deacetylas enhanc gene high chromatin complex compon conform crystal deacetylas enzym form histon level low modif mutat popul recruit regul suggest transcript yeast histon modif recruit structur substrat subunit transcript 53: NAD (47) 54: O-Acetyl-ADP-Ribose (2) activ biochem biosynthesi catalyt catalyz cell activ alter chromatin control dehydrogenas effect enzym chang conserv decreas function enzymat human metabol pathwai protein reaction complex enzym gene histon increas mutant peptid recombin reductas respons substrat treatment splice substrat variant wild-typ yeast 55: Mutagens (252) 56: RNA, Viral (502) assai assess carcinogen chemic damag dna dose antivir capsid genom hbv hcv hepat hiv hiv-1 host effect expos exposur frequenc human immunodefici infect infecti particl replic genotox increas indic induc mutagen potenti studi toxic worker rna viral virion viru virus 7 57: Fluorouracil (367) 58: Factor VIII (63) advanc agent cancer chemotherapi associ bleed
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  • Supplementary Table S4. FGA Co-Expressed Gene List in LUAD

    Supplementary Table S4. FGA Co-Expressed Gene List in LUAD

    Supplementary Table S4. FGA co-expressed gene list in LUAD tumors Symbol R Locus Description FGG 0.919 4q28 fibrinogen gamma chain FGL1 0.635 8p22 fibrinogen-like 1 SLC7A2 0.536 8p22 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 DUSP4 0.521 8p12-p11 dual specificity phosphatase 4 HAL 0.51 12q22-q24.1histidine ammonia-lyase PDE4D 0.499 5q12 phosphodiesterase 4D, cAMP-specific FURIN 0.497 15q26.1 furin (paired basic amino acid cleaving enzyme) CPS1 0.49 2q35 carbamoyl-phosphate synthase 1, mitochondrial TESC 0.478 12q24.22 tescalcin INHA 0.465 2q35 inhibin, alpha S100P 0.461 4p16 S100 calcium binding protein P VPS37A 0.447 8p22 vacuolar protein sorting 37 homolog A (S. cerevisiae) SLC16A14 0.447 2q36.3 solute carrier family 16, member 14 PPARGC1A 0.443 4p15.1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha SIK1 0.435 21q22.3 salt-inducible kinase 1 IRS2 0.434 13q34 insulin receptor substrate 2 RND1 0.433 12q12 Rho family GTPase 1 HGD 0.433 3q13.33 homogentisate 1,2-dioxygenase PTP4A1 0.432 6q12 protein tyrosine phosphatase type IVA, member 1 C8orf4 0.428 8p11.2 chromosome 8 open reading frame 4 DDC 0.427 7p12.2 dopa decarboxylase (aromatic L-amino acid decarboxylase) TACC2 0.427 10q26 transforming, acidic coiled-coil containing protein 2 MUC13 0.422 3q21.2 mucin 13, cell surface associated C5 0.412 9q33-q34 complement component 5 NR4A2 0.412 2q22-q23 nuclear receptor subfamily 4, group A, member 2 EYS 0.411 6q12 eyes shut homolog (Drosophila) GPX2 0.406 14q24.1 glutathione peroxidase