Occurrence, Fate, and Ecotoxicity of Antibiotics in Agro-Ecosystems. a Review Du, Liu
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Occurrence, fate, and ecotoxicity of antibiotics in agro-ecosystems. A review Du, Liu To cite this version: Du, Liu. Occurrence, fate, and ecotoxicity of antibiotics in agro-ecosystems. A review. Agron- omy for Sustainable Development, Springer Verlag/EDP Sciences/INRA, 2012, 32 (2), pp.309-327. 10.1007/s13593-011-0062-9. hal-00930539 HAL Id: hal-00930539 https://hal.archives-ouvertes.fr/hal-00930539 Submitted on 1 Jan 2012 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Agron. Sustain. Dev. (2012) 32:309–327 DOI 10.1007/s13593-011-0062-9 REVIEW ARTICLE Occurrence, fate, and ecotoxicity of antibiotics in agro-ecosystems. A review Lianfeng Du & Wenke Liu Accepted: 14 October 2011 /Published online: 18 November 2011 # INRA and Springer-Verlag, France 2011 Abstract Globally, besides human medicine, an increasing ecosystems and possible food security and public health amount of antibiotics as veterinary drugs and feed additives impacts. Three topics were discussed: (1) the occurrence, are used annually in many countries with the rapid fates, and ecological impacts of antibiotics in agro- development of the breeding industry (livestock breeding ecosystems, a global agro-ecological issue; (2) the potential and aquaculture). As a result, mostly ingested antibiotic ecological risks and public health threat of antibiotic doses (30–90%) and their metabolites to humans and pollution in soil–vegetable system, especially protected animals, as emerging persistent contaminants, were excret- vegetable and organic vegetable production systems; and ed together with urine and feces, and subsequently (3) the strategies of reducing the introduction, accumula- disseminated into environmental compartments in forms tion, and ecological risks of antibiotics in agro-ecosystems. of urban wastewater, biosolids, and manures. More impor- To summarize, environmental contamination of antibiotics tantly, significant amount of antibiotics and their bioactive has become increasingly serious worldwide, which poses metabolites or degradation products were introduced in great risks in agro-ecosystems. Notably, protected vegetable agro-ecosystems through fertilization and irrigation with and organic vegetable production systems, as public health antibiotics-polluted manures, biosolids, sewage sludge, closely related agro-ecosystems, are susceptible to antibi- sediments, and water. Subsequently, accumulation and otic contamination. Occurrence, fate, and ecotoxicity of transport of antibiotics in soil–crop systems, particularly antibiotics in agro-ecosystems, therefore, have become soil–vegetable systems, e.g., protected vegetable and most urgent issues among antibiotic environmental prob- organic vegetable production systems, poses great risks on lems. Nowadays, source control, including reducing use crops, soil ecosystem, and quality of groundwater- and and lowering environmental release through pretreatments plant-based products. The aim of this review is to explore of urban wastes and manures is a feasible way to alleviate the sources, fates (degradation, adsorption, runoff, leaching, negative impacts of antibiotics in agro-ecosystems. and crop uptake), and ecological risks of antibiotics in agro- Keywords Antibiotics . Ecological risks . Agro-ecosystem . L. Du Soil–vegetable system . Fate Institute of Plant Nutrition and Resources, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China Contents 1. Introduction..............................2 W. Liu (*) 2. Pathways of antibiotics entering agro-ecosystems...5 Institute of Environment and Sustainable Development 2.1 Fertilization with animal manures and urban in Agriculture, Chinese Academy of Agricultural Sciences, Beijing 100081, China wastes polluted by antibiotics...............5 e-mail: [email protected] 2.1.1 Concentrations of antibiotics in raw animal manures and urban biosolids................5 W. Liu 2.1.2 Antibiotic concentrations in treated animal Key Lab. of Energy Conservation and Waste Management of Agricultural Structures, Ministry of Agriculture, manures and urban biosolids................6 Beijing 100081, China 2.2 Irrigation with water polluted by antibiotics.....6 310 L.Du, W. Liu 3. Fates of antibiotic in agro-ecosystems............7 that the total amounts of annual use of antibiotics had 3.1 Soil accumulation.......................8 reached 100,000–200,000 tons worldwide (Wang and Tang 3.2 Adsorption and degradation.................8 2010), including veterinary antibiotics and medical anti- 3.3 Leaching and runoff.....................9 biotics. Among them, veterinary antibiotics are in the 3.4 Crop uptake...........................9 majority of the total amount used. For example, they 4. Effect of antibiotics in agro-ecosystems...........9 approximately accounted for 70% of the total consumption 4.1 Impacts on soil microorganisms and soil enzyme in the USA and about 70% of them are used for activity..................................9 nontherapeutic purposes (Sassman and Lee 2005; UCS 4.2 Phytotoxicity...........................10 2001). Although the inclusion of antibiotics in feed for 5. Risks related to antibiotics in agro-ecosystems, growth promotion in livestock production was banned in particularly PV-OVPS......................10 the European Union in 1998 (CEC 1998a, b) and Korea 5.1 Use necessity, benefits and antibiotic risks of will cease the use of growth promotion antibiotics feed organic fertilizer in PV-OVPS..................10 additives by 2012 (Kim et al. 2011), large-scale use of 5.2 Antibiotic pollution of agro-ecosystems, particularly antibiotics in animal production is being widely adopted PV-OVPS..............................11 worldwide as drugs, particularly in the European Union, 5.2.1 Soil, groundwater pollution...........11 USA (Kolpin et al. 2002), China (Zhao et al. 2010), 5.2.2 Vegetable pollution by antibiotics.......12 Southeast Asia, and Russia as feed additives or for 6. Research prospects.........................12 prophylactic, metaphylactic, and therapeutic purposes 6.1 Fates and ecological risks of antibiotics in agro- (Hamscher et al. 2003; Sarmah et al. 2006). China is the ecosystems: a global agro-ecological issue........12 largest country for production and use of antibiotics. In 6.2 Fates and ecological risks of antibiotics in PV- 2003, China produced 28,000 and 10,000 tons of penicillin OVPS: an urgent agro-ecological issue...........13 and oxytetracycline (OTC), occupying 60% and 65% of the 6.3 Strategies of lowering the introduction and ecological global total output (Yang et al. 2010a). On the other hand, impacts of antibiotics in agro-ecosystems...........13 antibiotics, as human medicines, have been extensively 6.3.1 Control the use of antibiotics as feed additives adopted in disease treatment globally, and their use and human medicines to reduce excretion rate....13 frequency and dosage often surpass the actual need. Taking 6.3.2 Developing pretreatment technology to China for example, the proportion of antibiotics in drug decrease the quantity of antibiotics in organic prescription was over 70% in China, much higher than fertilizer and irrigation water...............13 the proportion 30% in western countries, which reflected 6.3.3 Clarifying fates and rhizosphere dynamics that the antibiotic misuse was more serious in China of antibiotics in agro-ecosystems............13 (Bruce et al. 2005). 7. Concluding remarks........................14 With the rapid development of stockbreeding (e.g., livestock and poultry raising) and aquaculture (e.g., fishery), an unprecedented increment in used amount of 1 Introduction veterinary antibiotics is undergoing. Among antibiotics, tetracyclines were the most commonly used, followed by Broadly defined, antibiotics are organic substances that are sulfonamides and macrolides that accounted for approxi- produced through the secondary metabolism of living mately 90% of the total antibiotics used in the UK and microorganisms or synthesized artificially or semi- more than 50% in Korea and Denmark (Kim et al. 2011). artificially that can kill other microorganisms or inhibit Subsequently, about 30–90% antibiotic doses to humans their growth or metabolic activity via biochemical actions and animals, both unaltered and their metabolites, were (Lancini and Parenti 1982; Thomashow and Weller 1995; excreted and released together with urine and feces after Thiele-Bruhn 2003). Mass production and use of antibiotics medication for incomplete absorption (Halling-Sørensen et in medicine and agriculture have existed and substantially al. 1998; Alcock et al. 1999; Winckler and Grafe 2001; benefited public health and agricultural productivity for Jjemba 2002a, b; Heberer 2002; Bound and Voulvoulis over 60 years (Knapp et al. 2010). Nowadays, a wide 2004; Phillips et al. 2004; Kumar et al. 2005b). Addition- variety of antibiotics are extensively applied worldwide as ally, the amount rate of antibiotics excreted varies with the drugs for preventing or treating human, animal, and plant antibiotic species, the use dosage,