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Huaqiang ZENG Team Leader and Principal Research Scientist Huaqiang ZENG Team Leader and Principal Research Scientist +65 6824 7115 [email protected] Team Leader and Principal Research Scientist, NanoBio Lab, Singapore, 2019-present Team Leader and Principal Research Scientist, Institute of Bioengineering and Nanotechnology, Singapore, 2014-2019 Assistant Professor, National University of Singapore, 2006-2013 Postdoctoral Research Fellow, The Scripps Research Institute, USA, 2002-2006 Ph.D. in Organic Chemistry, The State University of New York at Buffalo, USA, 2002 B.S. in Chemical Physics, The University of Science and Technology of China, 1996 Publications 1. A. Roy, H. Joshi, R. Ye, J. Shen, F. Chen, A. Aksimentiev and H. Zeng, “Polyhydrazide‐Based Organic Nanotubes as Efficient and Selective Artificial Iodide Channels,” Angewandte Chemie International Edition, 132 (2020) 4836-4843. IF 12.102 2. J. Shen, J. Fan, R. Ye, N. Li, Y. Mu and H. Zeng, “Polypyridine-Based Helical Amide Foldamer Channels for Rapid Transport of Water and Proton with High Ion Rejection,” Angewandte Chemie International Edition, (2020) DOI: 10.1002/anie.202003512. IF 12.257 3. J. Shen, R. Ye, A. Romanies, A. Roy, F. Chen, C. Ren, Z. Liu and H. Zeng, “An Aquafoldmer-Based Aquaporin-Like Synthetic Water Channel,” Journal of the American Chemical Society, 142 (2020) 10050-10058. IF 14.695 4. H. Zeng, A. Roy, H. Joshi, R. Ye, J. Shen, F. Chen and A. Aksimentiev, “Polyhydrazide-Based Organic Nanotubes as Extremely Efficient and Highly Selective Artificial Iodide Channels,” Angew. Chem. Int. Ed., (2020) DOI: 10.1002/anie.201916287 5. H. Zeng, F. Chen, J. Shen, N. Li, A. Roy, R. Ye, and C. Ren, “Pyridine/Oxadiazole-Based Helical Foldamer Ion Channels with Exceptionally High K+/Na+ Selectivity,” Angew. Chem. Int. Ed., (2019) 10.1002/anie.201906341 6. Y. Zhang, Y. Zhong, A. L. Connor, D. P. Miller, R. Cao, J. Shen, B. Song, E. S. Baker, Q. Tang, S. V. S. R. K. Pulavarti, R. Liu, Q. Wang, Z.-l. Lu, T. Szyperski, H. Zeng, X. Li, R. D. Smith, E. Zurek, J. Zhu, and B. Gong, “Folding and Assembly of Short α, β, γ-Hybrid Peptides: Minor Variations in Sequence and Drastic Differences in Higher-Level Structures,” J. Am. Chem. Soc., 141 (2019) 14239-14248 7. F. Zeng, F. Liu, L. Yuan, S. Zhou, J. Shen, N. Li, H. Ren and H. Zeng, “A Pore-Forming Tripeptide as an Extraordinarily Active Anion Channel,” Org. Lett., 21[12] (2019) 4826-4830 Dr. Huaqiang Zeng 8. R. Ye, C. Ren, J. Shen, F. Chen, N. Li, A. Roy, and H. Zeng, “Molecular Ion Fishers as Highly Active and Exceptionally Selective K+ Transporters,” J. Am. Chem. Soc., 141[25] (2019) 9788-9792 9. L. Yuan, J. Shen, R. Ye, F. Chen and H. Zeng, “Structurally Simple Trimesic Amides as Highly Selective Anion Channels,” Chem. Commun., 55 (2019) 4797-4800 10. C. L. Ren, F. Chen, R. J. Ye, Y. S. Ong, H. F. Lu, S. S. Lee, J. Y. Ying and H. Zeng, “Molecular Swings as Extremely Active Ion Transporters,” Angewandte Chemie International Edition, 58[24] (2019) 8034- 8038 11. C. Ren, F. Zeng, J. Shen, F. Chen, A. Roy, S. Zhou, H. Ren and H. Zeng, “Pore-Forming Monopeptides as Exceptionally Active Anion Channels,” Journal of the American Chemical Society, 140 (2018) 8817- 8826 12. C. Ren, X. Ding, A. Roy, J. Shen, S. Zhou, F. Chen, S. F. Yau Li, H. Ren, Y. Y. Yang and H. Zeng, “A Halogen Bond-Mediated Highly Active Artificial Chloride Channel with High Anticancer Activity,” Chemical Science, 9 (2018) 4044-4051 13. J. Li, Y. Huo and H. Zeng, “Combinatorial Identification of a Highly Soluble Phase-Selective Organogelator with High Gelling Capacity for Crude Oil Gelation,” Journal of Materials Chemistry A, 6 (2018) 10196-10200 14. J. T. Li, Y. P. Huo and H. Q. Zeng, “Polar Solvent-Induced Unprecedented Supergelation of (Un)Weathered Crude Oils at Room Temperature,” Langmuir, 34 (2018) 8058-8064 15. J. Li, M. Liu, Y. Huo and H. Zeng, “DMSO-Accelerated Rapid Gelation of Crude Oils at Room Temperature,” Supramolecular Chemistry, 30 (2018) 1011-1016 16. S. Zhao, L. Zeng, G. Cheng, L. Yu and H. Q. Zeng, “Ni/Co-Based Metal-Organic Frameworks as Electrode Material for High Performance Supercapacitors,” Chinese Chemical Letters, (2018) DOI: 10.1016/j.cclet.2018.1010.1018 17. J. Xiong, L. J. Wang, J. Qian, P. P. Wang, X. J. Wang, G. L. Ma, H. Zeng, J. Li and J. F. Hu, “Structurally Diverse Sesquiterpenoids from the Endangered Ornamental Plant Michelia Shiluensis,” Journal of Natural Products, 81 (2018) 2195-2204 18. J. Shen, C. L. Ren and H. Q. Zeng, “Surprisingly High Selectivity and High Affinity in Mercury Recognition by H-Bonded Cavity-Containing Aromatic Foldarands,” Journal of the American Chemical Society, 139 (2017) 5387-5396 19. C. L. Ren, J. Shen and H. Q. Zeng, “Combinatorial Evolution of Fast-Conducting Highly Selective K+- Channels via Modularly Tunable Directional Assembly of Crown Ethers,” Journal of the American Chemical Society, 139 (2017) 12338-12341 20. C. L. Ren, J. Shen, F. Chen and H. Q. Zeng, “Rapid Room-Temperature Gelation of Crude Oils by a Wetted Powder Gelator,” Angewandte Chemie International Edition, 56 (2017) 3847-3851 21. H. Zhao, J. Shen, C. Ren, W. Zeng and H. Zeng, “A Foldamer-Based Organocatalyst for Direct Arylations of Unactivated Arenes,” Organic Letters, 19 (2017) 2190-2193 22. J. Li, Y. Huo, M. Liu and H. Q. Zeng, “Phase-Selective Organogelators for Oil Spill Treatment,” Progress in Chemistry, 29 (2017) 617-627 Dr. Huaqiang Zeng 23. K. H. Lee and H. Zeng, “Aptamer-Based ELISA Assay for Highly Specific and Sensitive Detection of Zika NS1 Protein,” Analytical Chemistry, 89 (2017) 12743-12748 24. K. H. Lee and H. Zeng, “A General Double Library SELEX Strategy for Aptamer Selection Using Unmodified Nonimmobilized Targets,” Analytical and Bioanalytical Chemistry, 409 (2017) 5081-5089 25. X. Hu, X. Chen, Y. Zhu, Y. F. Deng, H. Q. Zeng, H. F. Jiang and W. Zeng, “Rh(III)-Catalyzed Carboamination of Propargyl Cycloalkanols with Arylamines via Csp2-H/Csp3-Csp3 Activation,” Organic Letters, 139 (2017) 3474-3477 26. Y. P. Huo and H. Q. Zeng, ““Sticky”-Ends-Guided Creation of Functional Hollow Nanopores for Guest Encapsulation and Water Transport,” Accounts of Chemical Research, 49 (2016) 922-930 27. J. Shen, C. L. Ren and H. Q. Zeng, “Tuning Cation-Binding Selectivity and Capacity via Side Chain- Dependent Molecular Packing in the Solid State,” Chemical Communications, 52 (2016) 10361-10364 28. C. L. Ren, G. H. B. Ng, H. Wu, K.-H. Chan, J. Shen, C. Teh, J. Y. Ying and H. Q. Zeng, “Instant Room- Temperature Gelation of Crude Oil by Chiral Organogelators,” Chemistry of Materials, 28 (2016) 4001-4008 29. C. Ren, F. Chen, F. Zhou, J. Shen, H. Su and H. Zeng, “Low-Cost Phase-Selective Organogelators for Rapid Gelation of Crude Oils at Room Temperature,” Langmuir, 32 (2016) 13510-13516 30. W.-J. Meng, J. Xiong, W.-X. Wang, H.-Y. Zhang, H. Zeng and J.-F. Hu, “Phlefargesiine A, a C16N2 Lycopodium Alkaloid with an Unprecedented [6/7/6/6]-Tetracyclic Skeleton From Phlegmariurus Fargesii,” Tetrahedron Letters, 57 (2016) 3218-3221 31. C. Li, L. Wu, L. Chen, X. Yuan, Y. Cai, W. Feng, N. Liu, Y. Ren, A. Sengupta, M. S. Murali, P. K. Mohapatra, G. Tao, H. Q. Zeng, S. Ding and L. Yuan, “Highly Efficient Extraction of Actinides With Pillar[5]Arene- Derived Diglycolamides in Ionic Liquids via a Unique Mechanism Involving Competitive Host-Guest Interactions,” Dalton Transactions, 45 (2016) 19299-19310 32. Y. P. Huo, H. Q. Zeng and Y. G. Zhang, “Integrating Metabolic Engineering and Heterogeneous Chemocatalysis: New Opportunities for Biomass to Chemicals,” ChemSusChem, 9 (2016) 1078-1080 33. Y. P. Huo, C. Q. Pan, S. Y. Wang, S. M. Ji, T. F. Kong, L. Gao, N. Cai and H. Q. Zeng, “Color-Tunable Solid- State Emissions of Zn(II) and Cd (II) Complexes Derived from Cyano-Modified 2-Substituted 8- Hydroxyquinolines,” Polyhedron, 119 (2016) 175-183 34. C.-L. Hu, J. Xiong, L.-X. Gao, J. Li, H. Q. Zeng, Y. Zou and J.-F. Hu, “Diterpenoids from the Shed Trunk Barks of the Endangered Plant Pinus Dabeshanensis and their PTP1B Inhibitory Effects,” RSC Advances, 6 (2016) 60467-60478 35. N. Hong, M. Li, Y. Yuan, T. Wang, M. Yi, H. Xu, H. Q. Zeng, J. Song and Y. Hong, “Dnd is a Critical Specifier of Primordial Germ Cells in the Medaka Fish,” Stem Cell Reports, 6 (2016) 411-421 36. Y. Liu, J. Shen, C. Sun, C. L. Ren and H. Q. Zeng, “Intramolecularly Hydrogen-Bonded Aromatic Pentamers as Modularly Tunable Macrocyclic Receptors for Selective Recognition of Metal Ions,” Journal of the American Chemical Society, 137 (2015) 12055-12063 Dr. Huaqiang Zeng 37. X. Li, B. Li, L. Chen, J. Hu, C. Wen, Q. Zheng, L. Wu, H. Q. Zeng, B. Gong and L. Yuan, “Liquid-Crystalline Mesogens Based on Cyclo[6]aramides: Distinctive Phase Transitions in Response to Macrocyclic Host- Guest Interactions,” Angewandte Chemie International Edition, 54 (2015) 11147-11152 38. C. Ren, J. Shen and H. Zeng, “One-Pot Synthesis of Strained Macrocyclic Pyridone Hexamers and Their High Selectivity toward Cu2+ Recognition,” Organic Letters, 17 (2015) 5946-5949 39. J. Xiong, Z.-L. Hong, L.-X. Gao, J. Shen, S.-T. Liu, G.-X. Yang, J. Li, H. Q. Zeng and J.-F. Hu, “Chlorabietols A-C, Phloroglucinol-Diterpene Adducts from the Chloranthaceae Plant Chloranthus oldhamii,” The Journal of Organic Chemistry, 80 (2015) 11080-11085 40. S. P. Teong, G. Yi, H. Q. Zeng and Y. Zhang, “The Effects of Emulsion on Sugar Dehydration to 5- Hydroxymethylfurfural in a Biphasic System,” Green Chemistry, 17 (2015) 3751-3755 41.
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