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MOVING SCIENCE FORWARD and IMPROVING PATIENT CARE the Dermatology Foundation Is the Leading Private Funding Source for Skin Disease Research

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MOVING SCIENCE FORWARD and IMPROVING PATIENT CARE the Dermatology Foundation Is the Leading Private Funding Source for Skin Disease Research 2O16 ANNUAL REPORT MOVING SCIENCE FORWARD AND IMPROVING PATIENT CARE The Dermatology Foundation is the leading private funding source for skin disease research. For over 50 years, the DF has provided research support that has enabled innovation in dermatology and advancements in patient care. Table of Contents 1 Report from the Trustees 19 Research Award Recipients 2 Year in Review 27 Medical and Scientific Committee 4 Featured Award Recipient 28 DF Clinical Symposia 6 Corporate Honor Society 29 Scientific Benefactors, Patrons, and Sponsors 7 Thomas B. Fitzpatrick Legacy Fund 30 DF Honorary Awards 7 Deferred Giving 34 Financial Highlights 8 Annenberg Circle 36 DF Governance 13 Leaders Society II 2016 DERMATOLOGY FOUNDATION ANNUAL REPORT Report from the Trustees Dear Colleagues: The Dermatology Foundation is truly a physician-led organization with nearly 200 volunteers from within our specialty helping to carry out our mission. These DF mem- bers invest their time and energy in fundraising, in serving on our Board of Trustees, and in reviewing dozens of research proposals each year to identify those with the greatest promise. They do so because they believe deeply in the need for research that advances physician practice and improves patient care. We appreciate these hard-working volunteers more than we can express and could not accomplish the work of the Foundation without them. We must also extend our gratitude to the many individuals whose contributions this year made it possible to continue supporting promising novel research. We are also grateful for the corporate donors who recognize the importance of our work and continue their steadfast support. Among this year's high points were two unexpected and magnificent gifts. Dr. Eugene J. Van Scott, the DF’s only remaining founder, donated $1 million for our Research Endowment Fund to ensure future funding, while long-time supporters Charles and Daneen Stiefel contributed $1 million for skin cancer research. We are humbled by their generosity and deeply grateful for the priority they place on our shared mission. Annual support directly impacts the DF's capacity to fund research each and every year. If you are not yet a member, please consider joining us. For those who are mem- bers, please consider furthering both your financial commitment and your outreach to colleagues who would be proud to invest in the ground-breaking research the DF supports. The future of patient care depends on the investments we make today in innovative research completed by talented physician scientists and investigators. Michael D. Tharp, M.D. Bruce U. Wintroub, M.D. PRESIDENT CHAIRMAN, BOARD OF TRUSTEES 2016 DERMATOLOGY FOUNDATION ANNUAL REPORT 1 2O16 year in review Advancing the Field The Dermatology Foundation's approach is simple but powerful. The DF invests in early ideas and research that have the strong potential to make major contributions to the field. Every contribution to the DF is another step towards advancing the We are deeply grateful to Dr. Stuart R. Lessin, a dedicated DF profession and improving the lives of the patients we care for. volunteer, who is the newest member of the Thomas B. Fitzpatrick Your generosity and commitment make a difference. To mea- Legacy Fund, with a gift of $100,000. He himself was the recipient sure the impact of your investment, the DF surveys its career devel- of a DF research fellowship and a career development award early opment award recipients every five years to evaluate the program's in his career. effectiveness. The 2015 survey affirmed that nearly 80 percent of In 2016, the Foundation also received two extraordinary gifts awardees remained in academic medicine and that nearly 75 per- of $1 million. Dr. Eugene J. Van Scott, provided $1 million to in- cent of them had received highly sought-after federal funds. These crease the Foundation's Research Endowment Fund to bolster its results clearly validate the DF's success in identifying and investing ability to fund future research. Charles and Daneen Stiefel’s $1 in our profession's future thought-leaders. million gift was bestowed to create three new multi-year awards The DF is second only to the National Institutes of Health in for skin cancer research. The DF is profoundly grateful for the gen- supporting dermatological research and remains the only private erosity of these long-time supporters and excited for the future source of funding devoted to advancing the entire specialty. At discoveries their gifts make possible. a time of declining federal support for medical research, the The Foundation is also grateful for the generous support of its support of the DF members is more vital than ever. corporate supporters, who contributed $2.04 million in 2016. This Individual dues contributions to the Foundation reached $2.7 amount is down 9 percent over last year, as the number of compa- million in 2016, representing a 1.3 percent increase over 2015. We nies serving dermatology continues to decline due to mergers and could not have achieved that result without the dedicated fund- acquisitions. We recognize our corporate donors for their steadfast raising of our board members and national network of volunteers. commitment. In 2016, the DF was able to welcome 23 new members to the The 2017 DF Clinical Symposia, as in years past, reached capaci- Annenberg Circle, with pledges of $25,000 or more. In addition, ty and received high praise from attendees. Nearly 400 physicians 29 Annenberg Circle members who had already fulfilled their attended to learn more about the latest and most relevant informa- pledges became AC Sustaining members with an additional con- tion from leaders in the field. The Foundation is pleased to note that tribution of $5,000 or more. The Leaders Society gained over 200 nine of this year's fourteen distinguished faculty presenters were new members with contributions of at least $1,500. We are espe- former or current DF award-recipients. Nearly $400,000 in net pro- cially pleased that 46 new Leaders Society members are within five ceeds from the event benefitted the Research Awards Program. The years of completing their residency training. The commitment of DF is grateful to the corporate donors who sponsored this year's these young members bodes well for the future of our field. symposia and recognizes Unilever, for its exceptional support. The specialty will only be as strong as the support it receives. — MICHAEL D. THARP, M.D., PRESIDENT 2 2016 DERMATOLOGY FOUNDATION ANNUAL REPORT $2.67 million in research awards Contributions from its many supporters in 2016, enable the Foundation provide $2.6 million in research awards to 52 outstanding individuals with promising research proposals. The awards included: 2 Charles & Daneen Stiefel Scholar in Autoimmune &/or Connective Tissue Diseases Career 37 Development 37 New and Renewed Awards Career Development Awards Research 8 Fellowships 5 Health Care/Public Policy Awards 6 Dermatologic Surgery 5 Grants 5 Physician Scientist 2 Scholar Awards 1 Science of Human Appearance 3 Dermatopathology Research CDA 7 Medical Dermatology 2 Women’s Health DF Research Award Funding (in millions) 2 Pediatric Dermatology $2.6 6 Basic Science Research $1.8 8 Fellowships 8 Dermatologist Investigator 5 Grants $0.03 $0.46 1 Patient Directed Investigation 4 Basic Science Research 1967 1987 1997 2017 2016 DERMATOLOGY FOUNDATION ANNUAL REPORT 3 Featured Award Recipient: Aimee S. Payne, M.D., Ph.D. I am indebted to the Stiefels and the Dermatology Foundation for supporting the basic science research into mechanisms of disease in pemphigus that facilitated the translational work in this study. This is an example of how focused study of a rare but well-defined disease has the potential to identify novel strategies to treat many other autoimmune diseases. — AIMEE S. PAYNE, M.D., PH.D. Photo on next page: Dr. Aimee Payne, M.D. (on left) pictured with Daneen and Charles Stiefel. AIMEE S. PAYNE, M.D. , PH.D. Stiefel Scholar Award-Recipient Publishes Breakthrough Study Dr. Payne recently published research with the potential to transform the treatment of autoimmune diseases. Some scientists are already calling her research, published last year in one of the world's top academic journals, a breakthrough. Dr. Payne's research focuses on pemphigus autoantibodies, The therapy Dr. Payne's lab designed targets pemphigus auto- which cause the rare, debilitating skin disease pemphigus vulgaris. antibodies, which recognize and destroy Dsg3 (desmoglein 3), The challenge for Dr. Payne's lab at the University of Pennsylvania a molecule critical to cell adhesion in the skin and mucous mem- was to find a way to eliminate those harmful antibodies without branes. Current treatment generally suppresses immune response, damaging good ones. Her team designed a therapy that, so far, with serious side effects. has proven successful in the culture dish and mice. Their study In designing their therapy, Dr. Payne and her colleagues were appeared in the July 8, 2016, issue of Science. inspired by the clinical success of a cancer therapy. It uses T cells Dr. Payne, now a University of Pennsylvania associate pro- with antigen receptors that have been engineered to incorporate fessor of dermatology, credits the two DF grants for advancing an antibody fragment that targets a distinctive antigen on the her research on pemphigus autoantibodies at critical points in cancer cell. Then these chimeric antigen receptor T cells (CAR-T cells) her career. are able to recognize and kill the cancer cells carrying this unique She says that her early DF funding, the 2006 Career Develop- cancer cell antigen. ment Award and Research Grant, was "key to my transition from Dr. Payne and her colleague, cancer immunologist Dr. Michael postdoctoral researcher to tenure track faculty" and supported C. Milone, engineered T-cell receptors to recognize, specifically and her until the funding of a subsequent NIH award.
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