WO 2017/213252 Al 14 December 2017 (14.12.2017) W !P O PCT

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/213252 Al 14 December 2017 (14.12.2017) W !P O PCT

(51) International Patent Classification: TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, C07D 413/04 (2006.01) C07D 271/07 (2006.01) EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, C07D 417/10 (2006.01) A01N 43/836 (2006.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (21) International Application Number: KM, ML, MR, NE, SN, TD, TG). PCT/JP20 17/02 1473 (22) International Filing Date: Published: 09 June 2017 (09.06.2017) — with international search report (Art. 21(3)) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 2016-1 15977 10 June 2016 (10.06.2016) 2016-239161 09 December 2016 (09.12.2016) (71) Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED [JP/JP]; 27-1, Shinkawa 2-chome, Chuo-ku, Tokyo, 1048260 (JP). (72) Inventors: ARIMORI, Sadayuki; c/o SUMITOMO CHEMICAL COMPANY, LIMITED, 2-1, Takatsukasa 4-chome, Takarazuka-shi, Hyogo, 6658555 (JP). YA- MAMOTO, Masaoki; c/o SUMITOMO CHEMICAL COMPANY, LIMITED, 2-1, Takatsukasa 4-chome, Takarazuka-shi, Hyogo, 6658555 (JP). (74) Agent: SAMEJIMA, Mutsumi et al; AOYAMA & PARTNERS, Umeda Hankyu Bldg. Office Tower, 8-1, Kakuda-cho, Kita-ku, Osaka-shi, Osaka, 5300017 (JP). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ,

(54) Title: OXADIAZOLE COMPOUND AND USE AS PESTICIDE

H H (57) Abstract: The present invention provides a compound having excellent control efficacies against pests. Specifically, the present invention provides a compound rep- N. ( I ) resented by formula (I): (wherein: A is a single bond, etc.; m is any one integer of 0 to O N 3; X is a single bond, a CR4R5, a NR6, or an oxygen atom; R2, R3, R4, and R5 are in dependently of each other a hydrogen atom, etc.; R6 is a hydrogen atom, etc.; n is 0, 1, F 3 7 7 or 2; Q is an oxygen atom, a NR , a N-CN, a N-NO2, etc.; R is a hydrogen atom, etc.; o G is a benzene ring, etc.; Y is a CR R R1 , etc.; and R8, R9, and R1 are independently of each other a hydrogen atom, etc.) having excellent control efficacies against pests. Description Title of Invention: OXADIAZOLE COMPOUND AND USE AS PESTICIDE Technical Field [0001] This application claims priorities to and the benefits of Japanese Patent Application Nos. 2016-115977 filed on June 10, 2016 and 2016-239161 filed on December 9, 2016, the entire contents of which are incorporated herein by reference. The present invention relates to an oxadiazole compound and use thereof. Background Art [0002] Patent Literature 1 discloses some compounds such as a compound represented by the following formula for medical use. [Chem.l]

Citation List Patent Literature [0003] PTL 1: WO 2013/008 162 pamphlet Summary of Invention Technical Problem [0004] An object of the present invention is to provide a compound having excellent control efficacies against pests. Solution to Problem [0005] The present inventors have intensively studied to find out a compound having excellent control efficacies against pests. As a result, they have found out that a compound represented by the following formula (I) has excellent control efficacies against pests. That is, the present invention provides the followings: [1] A compound represented by formula (I): [Chem.2]

[wherein: A is a single bond, a NR1, or an oxygen atom; m is any one integer of 0 to 3; R1 is a C1-C6 alkyl group optionally having one or more halogen atoms, or a hydrogen atom; X is a single bond, a CR4R5, a NR6, or an oxygen atom; R2, R3, R4, and R5 are independently of each other a C1-C6 alkyl group optionally having one or more substituents selected from Group A, a C1-C6 alkoxy group op tionally having one or more substituents selected from Group B, a phenyl group op tionally having one or more substituents selected from Group D, a pyridyl group op tionally having one or more substituents selected from Group D, a C3-C6 cycloalkyl group optionally having one or more substituents selected from Group D, a hydrogen atom, a halogen atom, or a cyano group, or R2 and R3 may be combined with the carbon atom to which they are attached to form a 3 to 6 membered ring (wherein said 3 to 6 membered ring may optionally have one or more substituents selected from Group D), wherein when m is 2 or 3, two or more R2 and R3 may be identical or different; R6 is a C1-C6 alkyl group optionally having one or more substituents selected from Group A, a C3-C6 alkenyl group optionally having one or more halogen atoms, a C3-C6 alkynyl group optionally having one or more halogen atoms, a C1-C6 alkoxy group optionally having one or more halogen atoms, a C3-C6 cycloalkyl group op tionally having one or more substituents selected from Group D, a phenyl group op tionally having one or more substituents selected from Group D, a 5 membered aromatic heterocyclic group optionally having one or more substituents selected from Group D, a 6 membered aromatic heterocyclic group optionally having one or more substituents selected from Group D, or a hydrogen atom; n is 0, 1, or 2; 7 7 7 Q is an oxygen atom, a NR , a N-CN, a N-N0 2, a N-C(0)R , a N-C(0)OR , or a N- 7 S(0) 2R (wherein when n is 2, two Q may be identical or different); R7 is a C1-C6 alkyl group optionally having one or more substituents selected from the group consisting of a halogen atom and a cyano group, or a hydrogen atom; G is a thiophene ring, a furan ring, an imidazole ring, an oxazole ring, an isoxazole ring, a thiazole ring, an oxadiazole ring, a thiadiazole ring, a pyridine ring, a pyrazine ring, a pyridazine ring, a pyrimidine ring, or a benzene ring {wherein said thiophene ring, said furan ring, said imidazole ring, said oxazole ring, said isoxazole ring, said thiazole ring, said pyridine ring, said pyrazine ring, said pyridazine ring, and said pyrimidine ring may optionally have one or more substituents selected from Group D, and when n is 0, said benzene ring may optionally have one or more substituents selected from Group I, and when n is 1 or 2, said benzene ring may optionally have one or more substituents selected from Group D}; Y is a C3-C6 cycloalkyl group optionally having one or more substituents selected from Group D, a phenyl group optionally having one or more substituents selected from Group D, a 5 membered aromatic heterocyclic group optionally having one or more substituents selected from Group D, a 6 membered aromatic heterocyclic group optionally having one or more substituents selected from Group G, a 3 to 6 membered nonaromatic heterocyclic group optionally having one or more substituents selected from Group D , a CR R R 10 , a NR R12 , or a OR 13 ; R8, R , and R10 are independently of each other a C1-C6 alkyl group optionally having one or more substituents selected from the group consisting of Group A and Group F, a C3-C6 alkenyl group optionally having one or more halogen atoms, a C3-C6 alkynyl group optionally having one or more halogen atoms, a C1-C6 alkoxy group optionally having one or more substituents selected from Group B, a C3-C6 cycloalkyl group op tionally having one or more substituents selected from Group D, a phenyl group op tionally having one or more substituents selected from Group D, a 5 to 6 membered aromatic heterocyclic group optionally having one or more substituents selected from Group D, a hydrogen atom, a halogen atom, or a cyano group; R 1 1 and R12 are independently of each other a C1-C6 alkyl group optionally having one or more substituents selected from the group consisting of Group E and Group F, a C3-C6 alkenyl group optionally having one or more halogen atoms, a C3-C6 alkynyl group optionally having one or more halogen atoms, a C1-C6 alkoxy group optionally having one or more halogen atoms, a C3-C6 cycloalkyl group optionally having one or more substituents selected from Group D, a phenyl group optionally having one or more substituents selected from Group D, a 5 to 6 membered aromatic heterocyclic group optionally having one or more substituents selected from Group D, or a hydrogen atom, or R 1 1 and R 12 may be combined with each other to form a 3 to 8 membered heterocyclic group (wherein said 3 to 8 membered heterocyclic group may optionally have one or more substituents selected from Group D); and R 13 is a C1-C6 alkyl group optionally having one or more substituents selected from the group consisting of Group A and Group F, a C3-C6 alkenyl group optionally having one or more halogen atoms, a C3-C6 alkynyl group optionally having one or more halogen atoms, a C3-C6 cycloalkyl group optionally having one or more substituents selected from Group D, a phenyl group optionally having one or more substituents selected from Group D, a 5 to 6 membered aromatic heterocyclic group op tionally having one or more substituents selected from Group D, or a hydrogen atom; when X is a CR4R5 and Y is a CR R R 10 , R4 and R8 may be combined with each other to form a 5 to 7 membered heterocyclic group (wherein said 5 to 7 membered hete rocyclic group may optionally have one or more substituents selected from Group D); when X is a CR4R5 and Y is a NR R 12, R4 and R 1 1 may be combined with each other to form a 5 to 7 membered heterocyclic group (wherein said 5 to 7 membered hete rocyclic group may optionally have one or more substituents selected from Group D); when X is a CR4R5 and Y is a OR 13 , R4 and R 13 may be combined with each other to form a 5 to 7 membered heterocyclic group (wherein said 5 to 7 membered hete rocyclic group may optionally have one or more substituents selected from Group D); when X is a NR6 and Y is a CR R R 10 , R6 and R8 may be combined with each other to form a 5 to 7 membered heterocyclic group (wherein said 5 to 7 membered hete rocyclic group may optionally have one or more substituents selected from Group D); when X is a NR6 and Y is a NR R 12, R6 and R 1 1 may be combined with each other to form a 5 to 7 membered heterocyclic group (wherein said 5 to 7 membered hete rocyclic group may optionally have one or more substituents selected from Group D); and when X is a NR6 and Y is a OR 13 , R6 and R 13 may be combined with each other to form a 5 to 7 membered heterocyclic group (wherein said 5 to 7 membered heterocyclic group may optionally have one or more substituents selected from Group D); Group A: a group consisting of a C1-C6 alkoxy group optionally having one or more halogen atoms, a C1-C6 alkylthio group optionally having one or more halogen atoms, a C3-C6 cycloalkyl group optionally having one or more substituents selected from Group C, a phenyl group optionally having one or more substituents selected from Group H, a 5 to 6 membered aromatic heterocyclic group optionally having one or more substituents selected from Group H, a halogen atom, a nitro group, and a cyano group; Group B: a group consisting of a C1-C6 alkylthio group optionally having one or more halogen atoms, a phenyl group optionally having one or more substituents selected from Group H, a 5 to 6 membered aromatic heterocyclic group optionally having one or more substituents selected from Group H, a halogen atom, a nitro group, and a cyano group; Group C: a group consisting of a halogen atom, a nitro group, and a cyano group; Group D: a group consisting of a C1-C6 alkyl group optionally having one or more substituents selected from Group C, a C3-C6 cycloalkyl group optionally having one or more substituents selected from Group C, a C1-C6 alkoxy group optionally having one or more halogen atoms, a C3-C6 alkenyloxy group optionally having one or more halogen atoms, a C3-C6 alkynyloxy group optionally having one or more halogen atoms, a C1-C6 alkylthio group optionally having one or more halogen atoms, a C1-C6 alkylsulfonyloxy group optionally having one or more halogen atoms, a halogen atom, a cyano group, and a nitro group; Group E: a group consisting of a C3-C6 cycloalkyl group optionally having one or more substituents selected from Group C, a C1-C6 alkoxy group optionally having one or more halogen atoms, a C1-C6 alkylthio group optionally having one or more halogen atoms, a phenyl group optionally having one or more substituents selected from Group H, a 5 to 6 membered aromatic heterocyclic group optionally having one or more substituents selected from Group H, a C1-C6 alkylsulfonyl group optionally having one or more halogen atoms, a C1-C6 alkylsulfonyloxy group optionally having one or more halogen atoms, and a halogen atom; Group F: a group consisting of a C2-C7 alkylcarbonylamino group optionally having one or more substituents selected from Group C, a C1-C6 alkylaminocarbonyl group optionally having one or more substituents selected from Group C, a di(Cl-C6 alkyl)aminocarbonyl group optionally having one or more substituents selected from Group C, a C1-C6 alkylsulfonylamino group optionally having one or more sub stituents selected from Group C, a C1-C6 alkylaminosulfonyl group optionally having one or more substituents selected from Group C, and a di(Cl-C6 alkyl)aminosulfonyl group optionally having one or more substituents selected from Group C; Group G: a group consisting of a C1-C6 alkyl group optionally having one or more substituents selected from Group C, a C3-C6 cycloalkyl group optionally having one or more substituents selected from Group C, a C1-C6 alkoxy group optionally having one or more halogen atoms, a C3-C6 alkenyloxy group optionally having one or more halogen atoms, a C3-C6 alkynyloxy group optionally having one or more halogen atoms, a C1-C6 alkylthio group optionally having one or more halogen atoms, a C1-C6 alkylsulfonyloxy group optionally having one or more halogen atoms, a halogen atom, and a nitro group; Group H: a group consisting of a C1-C6 alkyl group optionally having one or more halogen atoms, a C1-C6 alkoxy group optionally having one or more halogen atoms, a halogen atom, and a cyano group; Group I: a group consisting of a C1-C6 alkyl group optionally having one or more sub stituents selected from Group C, a C3-C6 cycloalkyl group optionally having one or more substituents selected from Group C, a C3-C6 alkenyloxy group optionally having one or more halogen atoms, a C3-C6 alkynyloxy group optionally having one or more halogen atoms, a C1-C6 alkylthio group optionally having one or more halogen atoms, a C1-C6 alkylsulfonyloxy group optionally having one or more halogen atoms, a fluorine atom, and a cyano group] (hereinafter referred to as "the compound of the present invention" or "the Present compound"). [2] The compound according to [1] wherein A is a single bond; m is 0; G is a benzene ring or a pyridine ring (wherein said benzene ring and said pyridine ring may optionally have one or more fluorine atoms); X is a single bond or a NR6; Q is an oxygen atom, a NH, a N-CN, a N-C(0)R 7, or a N-C(0)OR 7; R7 is a C1-C6 alkyl group; Y is a C3-C6 cycloalkyl group optionally having one or more halogen atoms, a phenyl group optionally having one or more halogen atoms, a CR R R 10 , or a NR R 12 ; R6 is a C1-C6 alkyl group (wherein said C1-C6 alkyl group may optionally have one or more substituents selected from the group consisting of a halogen atom, a C1-C6 alkoxy group, a C1-C6 alkylthio group, a C3-C6 cycloalkyl group, and a phenyl group), a C3-C6 alkynyl group optionally having one or more halogen atoms, a C3-C6 cycloalkyl group optionally having one or more halogen atoms, a phenyl group (wherein said phenyl group may optionally have one or more substituents selected from the group consisting of a halogen atom, a C1-C6 alkyl group, and a C1-C6 alkoxy group), or a hydrogen atom; R8, R , and R10 are independently of each other a C1-C6 alkyl group optionally having one or more halogen atoms, a phenyl group, a hydrogen atom, or a halogen atom; R 1 1 and R12 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to said benzene ring or said pyridine ring represented by G at the para position relative to the oxadiazole ring. [3] The compound according to [1] wherein A is a single bond; m is 0; G is a benzene ring or a pyridine ring (wherein said benzene ring and said pyridine ring may optionally have one or more fluorine atoms); X is a single bond or a NR6; Q is an oxygen atom, a NH, or a N-CN; Y is a C3-C6 cycloalkyl group optionally having one or more halogen atoms, a CR R R 10 , or a NR R12 ; R6 is a C1-C6 alkyl group optionally having one or more halogen atoms, or a hydrogen atom; R8, R , and R 10 are independently of each other a C1-C6 alkyl group optionally having one or more halogen atoms, or a hydrogen atom; and R 1 1 and R 12 are independently of each other a C1-C6 alkyl group (wherein said C1-C6 alkyl group may optionally have one or more substituents selected from the group consisting of a halogen atom, a C3-C6 cycloalkyl group, and a C1-C6 alkoxy group), a C3-C6 alkynyl group optionally having one or more halogen atoms, a C3-C6 cy cloalkyl group optionally having one or more halogen atoms, or a hydrogen atom, or R 1 1 and R 12 are combined with each other to form a 3 to 6 membered heterocyclic group (wherein said 3 to 6 membered heterocyclic group may optionally have one or more halogen atoms). [4] The compound according to any one of [1] to [3] wherein G is a benzene ring optionally having one or more fluorine atoms; and Y is a C3-C6 cycloalkyl group optionally having one or more halogen atoms, or a CR8 R R 10 . [5] The compound according to any one of [1] to [4] wherein G is a benzene ring optionally having one or more fluorine atoms; X is a single bond; and Y is a CR R R 10 . [6] The compound according to any one of [1] to [4] wherein G is a benzene ring optionally having one or more fluorine atoms; X is a NR6; n is 2; Q is an oxygen atom; and Y is a CR R R 10 , or a C3-C6 cycloalkyl group optionally having one or more halogen atoms. [7] The compound according to any one of [1] to [3] wherein G is a benzene ring optionally having one or more fluorine atoms; X is a single bond; n is 2; Q is an oxygen atom; and Y is a NR R 12. [8] An agent for controlling a pest comprising the compound according to any one of [I] to [7] (hereinafter, also referred to as "the control agent of the present invention"). [9] A method for controlling a pest, the method comprising applying an effective amount of the compound according to any one of [1] to [7] to a plant or a soil. [10] Use of the compound according to any one of [1] to [7] for controlling a pest. [I I] A composition comprising one or more agents selected from the group consisting of a fungicide, an insecticide, a miticide, a nematicide, a plant growth regulator, and a synergist, and the compound according to any one of [1] to [7]. [0006] The present invention can control pests. Description of Embodiments [0007] The substituent(s) as described herein is/are explained as follows. In the present description, when a substituent has two or more halogen atoms, these halogen atoms may be identical to or different from each other. The expression of "optionally having one or more substituents selected from Group X" (wherein "X" is any one of A to I or a combination thereof) as described herein represents that when two or more substituents selected from Group X are present, these substituents may be identical to or different from each other. The expression of "CX-CY" as described herein means that the number of carbon atom is X to Y. For example, the expression of "C1-C6" means that the number of carbon atom is 1 to 6. [0008] The term of "halogen atom" represents fluorine atom, chlorine atom, bromine atom, or iodine atom. Examples of "alkyl group" include methyl group, ethyl group, n-propyl group, isopropyl group, 1,1-dimethylpropyl group, 1,2-dimethylpropyl group, 1-ethylpropyl group, n-butyl group, isobutyl group, tert-butyl group, pentyl group, and hexyl group. Examples of "alkenyl group" include vinyl group, 1-propenyl group, 2-propenyl group, 1-methyl- 1-propenyl group, l-methyl-2-propenyl group, 1,2-dimethyl- 1-propenyl group, l,l-dimethyl-2-propenyl group, 1-ethyl- 1-propenyl group, l-ethyl-2-propenyl group, 3-butenyl group, 4-pentenyl group, and 5-hexenyl group. Examples of "alkynyl group" include ethynyl group, 1-propynyl group, 2-propynyl group, l-methyl-2-propynyl group, l,l-dimethyl-2-propynyl group, l-ethyl-2-propynyl group, 2-butynyl group, 4-pentynyl group, and 5-hexynyl group. The expression of "5 to 6 membered aromatic heterocyclic group" represents a 5 membered aromatic heterocyclic group or a 6 membered aromatic heterocyclic group. The "5 membered aromatic heterocyclic group" represents pyrrolyl group, furyl group, thienyl group, pyrazolyl group, imidazolyl group, triazolyl group, tetrazolyl group, oxazolyl group, isooxazolyl group, thiazolyl group, oxadiazolyl group, or thiadiazolyl group. The "6 membered aromatic heterocyclic group" represents pyridyl group, pyridazinyl group, pyrimidinyl group, or pyrazinyl group. [0009] In the compound of the present invention, the compound wherein R2 and R3 are combined with the carbon atom to which they are attached to form a 3 to 6 membered ring represents any one structure of the followings (ZA1 to ZA4). [Chem.3

[0010] In NR R 12 , the 3 to 8 membered heterocyclic group formed by combining R 1 1 and R 12 with each other represents any one structure of the followings (ZB1 to ZB21) (wherein the symbol "·" represents the point of attachment). [001 1] In NR R 12 , the 3 to 6 membered heterocyclic group formed by combining R 1 1 and R 12 with each other represents any one structure of the followings (ZB 1 to ZB4 and ZB7 to ZB21) (wherein the symbol "·" represents the point of attachment). [0012] [Chem.4]

(ZB1) (ZB2) (ZB4) (ZB5) (ZB6)

(ZB9) (ZB1 0) (ZB1 ) (ZB1 2) (ZB1 3) (Z B )

[0013] When X is a CR4R5 and Y is a CR R R 10, the 5 to 7 membered heterocyclic group formed by combining R4 and R8 with each other represents any one structure of the followings (ZC1 to ZC3) (wherein the symbol "·" represents the point of attachment). [Chem.5]

(ZC1) 2C2 (2C3) [0014] When X is a CR4R5 and Y is a NR R 12 , the 5 to 7 membered heterocyclic group formed by combining R4 and R 1 1 with each other represents any one structure of the followings (ZD1 to ZD3) (wherein the symbol "·" represents the point of attachment). [Chem.6]

(ZD1) (ZD2) (ZD3) [0015] When X is a CR4R5 and Y is a OR 13 , the 5 to 7 membered heterocyclic group formed by combining R4 and R 13 with each other represents any one structure of the followings (ZE1 to ZE3) (wherein the symbol "·" represents the point of attachment). [Chem.7]

(ZE1) (ZE2) (ZE3) [0016] When X is a NR6 and Y is a CR R R 10, the 5 to 7 membered heterocyclic group formed by combining R6 and R8 with each other represents any one structure of the followings (ZF1 to ZF3) (wherein the symbol "·" represents the point of attachment). [0017] [Chem.8]

(ZF1) (ZF2) (ZF3) When X is a NR6 and Y is a NR R12 , the 5 to 7 membered heterocyclic group formed by combining R6 and R 1 1 with each other represents any one structure of the followings (ZG1 to ZG4) (wherein the symbol "·" represents the point of attachment). Chem.9]

(ZG1) (ZG2) (ZG3) (ZG4)

When X is a NR6 and Y is a OR 13 , the 5 to 7 membered heterocyclic group formed by combining R6 and R 13 with each other represents any one structure of the followings (ZH1 to ZH3) (wherein the symbol "·" represents the point of attachment). [Chem.lO]

(ZH 1) (ZH2) (ZH3) [0020] The compound of the present invention comprising one or more stereogenic centers includes optical isomers each singly and any mixture composed of these isomers each in an arbitrary ratio of the respective isomer. Further, the compound of the present invention comprising two or more geometric isomer derived from carbon-carbon double bond, carbon-nitrogen bond, sulfur-oxygen bond, sulfur-nitrogen bond, cyclic structure, or the like includes geometric isomers each singly and any mixture composed of these isomers each in an arbitrary ratio of the respective isomer. [0021] The compound of the present invention may form an acid addition salt such as h y drochloride, sulfate, nitrate, phosphate, acetate, and benzoate by mixing the compound with an acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, and benzoic acid. [0022] Embodiments of the compound of the present invention include the following compounds. [0023] [Embodiment 1] The compound of the present invention, wherein G is a benzene ring or a pyridine ring (wherein said benzene ring and said pyridine ring may optionally have one or more fluorine atoms); X is a single bond or a NR6; Q is an oxygen atom, a NH, or a N-CN; Y is a C3-C6 cycloalkyl group optionally having one or more halogen atoms, a CR R R 10 , or a NR R12 ; R6 is a C1-C6 alkyl group optionally having one or more halogen atoms, or a hydrogen atom; R8, R , and R10 are independently of each other a C1-C6 alkyl group optionally having one or more halogen atoms, or a hydrogen atom; and R 1 1 and R12 are independently of each other a C1-C6 alkyl group (wherein said C1-C6 alkyl group may optionally have one or more substituents selected from the group consisting of a halogen atom, a C3-C6 cycloalkyl group, and a C1-C6 alkoxy group), a C3-C6 alkynyl group optionally having one or more halogen atoms, a C3-C6 cy cloalkyl group optionally having one or more halogen atoms, or a hydrogen atom, or R 1 1 and R12 are combined with each other to form a 3 to 6 membered heterocyclic group (wherein said 3 to 6 membered heterocyclic group may optionally have one or more halogen atoms). [Embodiment 2] The compound of the present invention, wherein G is a benzene ring (wherein said benzene ring may optionally have one or more fluorine atoms); X is a single bond or a NR6; Q is an oxygen atom, a NH, or a N-CN; Y is a C3-C6 cycloalkyl group optionally having one or more halogen atoms, a CR R R 10 , or a NR R12 ; R6 is a C1-C6 alkyl group optionally having one or more halogen atoms, or a hydrogen atom; R8, R , and R10 are independently of each other a C1-C6 alkyl group optionally having one or more halogen atoms, or a hydrogen atom; R 1 1 and R12 are independently of each other a C1-C6 alkyl group (wherein said C1-C6 alkyl group may optionally have one or more substituents selected from the group consisting of a halogen atom, a C3-C6 cycloalkyl group, and a C1-C6 alkoxy group), a C3-C6 alkynyl group optionally having one or more halogen atoms, a C3-C6 cy cloalkyl group optionally having one or more halogen atoms, or a hydrogen atom, or R 1 1 and R12 are combined with each other to form a 3 to 6 membered heterocyclic group (wherein said 3 to 6 membered heterocyclic group may optionally have one or more halogen atoms). [Embodiment 3] The compound of the present invention, wherein G is a benzene ring (wherein said benzene ring may optionally have one or more fluorine atoms); X is a single bond or a NR6; Q is an oxygen atom, a NH, or a N-CN; Y is a C3-C6 cycloalkyl group optionally having one or more halogen atoms, a CR R R 10 , or a NR R12 ; R6 is a C1-C6 alkyl group optionally having one or more halogen atoms, or a hydrogen atom; R8, R , and R10 are independently of each other a C1-C6 alkyl group optionally having one or more halogen atoms, or a hydrogen atom; R 1 1 and R12 are independently of each other a C1-C6 alkyl group (wherein said C1-C6 alkyl group may optionally have one or more substituents selected from the group consisting of a halogen atom, a C3-C6 cycloalkyl group, and a C1-C6 alkoxy group), a C3-C6 alkynyl group optionally having one or more halogen atoms, a C3-C6 cy cloalkyl group optionally having one or more halogen atoms, or a hydrogen atom, or R 1 1 and R12 are combined with each other to form a 3 to 6 membered heterocyclic group (wherein said 3 to 6 membered heterocyclic group may optionally have one or more halogen atoms); and A is attached to G at the para position or the meta position relative to the oxadiazole ring. [Embodiment 4] The compound of the present invention, wherein G is a benzene ring (wherein said benzene ring may optionally have one or more fluorine atoms); X is a single bond or a NR6; Q is an oxygen atom, a NH, or a N-CN; Y is a C3-C6 cycloalkyl group optionally having one or more halogen atoms, a CR R R 10 , or a NR R12 ; R6 is a C1-C6 alkyl group optionally having one or more halogen atoms, or a hydrogen atom; R8, R , and R10 are independently of each other a C1-C6 alkyl group optionally having one or more halogen atoms, or a hydrogen atom; R 1 1 and R12 are independently of each other a C1-C6 alkyl group (wherein said C1-C6 alkyl group may optionally have one or more substituents selected from the group consisting of a halogen atom, a C3-C6 cycloalkyl group, and a C1-C6 alkoxy group), a C3-C6 alkynyl group optionally having one or more halogen atoms, a C3-C6 cy cloalkyl group optionally having one or more halogen atoms, or a hydrogen atom, or R 1 1 and R12 are combined with each other to form a 3 to 6 membered heterocyclic group (wherein said 3 to 6 membered heterocyclic group may optionally have one or more halogen atoms); and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 5] The compound of the present invention, wherein G is a benzene ring; m is 0; X is a single bond or a NR6; Q is an oxygen atom; n is 2; Y is a C3-C6 cycloalkyl group, a CR R R10, or a NR R12 ; R6 is a C1-C6 alkyl group optionally having one or more halogen atoms, a C3-C6 alkynyl group, a C3-C6 cycloalkyl group, or a hydrogen atom; R8, R , and R10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; R 1 1 and R12 are independently of each other a C1-C6 alkyl group; and A is attached to said benzene ring represented by G at the para position relative to the oxadiazole ring. [Embodiment 6] The compound of the present invention, wherein G is a benzene ring; m is 0; X is a single bond or a NR6; Q is an oxygen atom; n is 2; Y is a C3-C6 cycloalkyl group or a CR R R10 ; R6 is a C1-C6 alkyl group optionally having one or more halogen atoms, a C3-C6 alkynyl group, a C3-C6 cycloalkyl group, or a hydrogen atom; R8, R , and R10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to said benzene ring represented by G at the para position relative to the oxadiazole ring. [Embodiment 7] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom, a NH, or a N-CN; G is a benzene ring optionally having one or more fluorine atoms; and Y is a C3-C6 cycloalkyl group optionally having one or more halogen atoms, or a CR

8R R 10_ [Embodiment 8] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom, a NH, or a N-CN; G is a benzene ring optionally having one or more fluorine atoms; Y is a C3-C6 cycloalkyl group optionally having one or more halogen atoms, or a CR R R10 ; and A is attached to G at the para position or the meta position relative to the oxadiazole ring. [Embodiment 9] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom, a NH, or a N-CN; G is a benzene ring optionally having one or more fluorine atoms; Y is a C3-C6 cycloalkyl group optionally having one or more halogen atoms, or a CR8

R R 10. R8, R9, and R10 are independently of each other a C1-C6 alkyl group optionally having one or more halogen atoms, or a hydrogen atom; and A is attached to G at the para position or the meta position relative to the oxadiazole ring. [Embodiment 10] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom, a NH, or a N-CN; G is a benzene ring optionally having one or more fluorine atoms; Y is a C3-C6 cycloalkyl group optionally having one or more halogen atoms, or a CR8

R R 10. R8, R9, and R10 are independently of each other a C1-C6 alkyl group optionally having one or more halogen atoms, or a hydrogen atom; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 11] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom, a NH, or a N-CN; G is a benzene ring optionally having one or more fluorine atoms; Y is a CR R R10 ; R8, R9, and R 10 are independently of each other a C1-C6 alkyl group optionally having one or more halogen atoms, or a hydrogen atom; and A is attached to G at the para position or the meta position relative to the oxadiazole ring. [Embodiment 12] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom, a NH, or a N-CN; G is a benzene ring; Y is a CR R R10 ; R8, R9, and R 10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to G at the para position or the meta position relative to the oxadiazole ring. [Embodiment 13] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom; G is a benzene ring; Y is a CR R R 10 ; R8, R9, and R10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to G at the para position or the meta position relative to the oxadiazole ring. [Embodiment 14] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom, a NH, or a N-CN; G is a benzene ring optionally having one or more fluorine atoms; Y is a CR R R 10 ; R8, R9, and R10 are independently of each other a C1-C6 alkyl group optionally having one or more halogen atoms, or a hydrogen atom; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 15] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom, a NH, or a N-CN; G is a benzene ring optionally having one or more fluorine atoms; Y is a CR R R10 ; R8, R9, and R 10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 16] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom, a NH, or a N-CN; G is a benzene ring; Y is a CR R R10 ; R8, R9, and R 10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 17] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom; G is a benzene ring; Y is a CR R R10 ; R8, R , and R10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 18] The compound of the present invention, wherein G is a benzene ring optionally having one or more fluorine atoms; X is a NR6; n is 2; Q is an oxygen atom; Y is a C3-C6 cycloalkyl group optionally having one or more halogen atoms, or a CR

8R R 10_ [Embodiment 19] The compound of the present invention, wherein G is a benzene ring; X is a NR6; n is 2; Q is an oxygen atom; Y is a C3-C6 cycloalkyl group optionally having one or more halogen atoms, or a CR R R10 ; and A is attached to G at the para position or the meta position relative to the oxadiazole ring. [Embodiment 20] The compound of the present invention, wherein G is a benzene ring; X is a NR6; R6 is a C1-C6 alkyl group optionally having one or more halogen atoms, or a hydrogen atom; n is 2; Q is an oxygen atom; Y is a C3-C6 cycloalkyl group optionally having one or more halogen atoms, or a CR

R8, R , and R 10 are independently of each other a C1-C6 alkyl group optionally having one or more halogen atoms, a C3-C6 alkynyl group, or a hydrogen atom; and A is attached to G at the para position or the meta position relative to the oxadiazole ring. [Embodiment 21] The compound of the present invention, wherein G is a benzene ring; X is a NR6; R6 is a C1-C6 alkyl group or a hydrogen atom; n is 2; Q is an oxygen atom; Y is a C3-C6 cycloalkyl group or a CR R R10 ; R8, R9, and R10 are independently of each other a C1-C6 alkyl group, a C3-C6 alkynyl group, or a hydrogen atom; and A is attached to G at the para position or the meta position relative to the oxadiazole ring. [Embodiment 22] The compound of the present invention, wherein G is a benzene ring; X is a NR6; R6 is a C1-C6 alkyl group or a hydrogen atom; n is 2; Q is an oxygen atom; Y is a C3-C6 cycloalkyl group or a CR R R10 ; R8, R9, and R 10 are independently of each other a C1-C6 alkyl group, a C3-C6 alkynyl group, or a hydrogen atom; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 23] The compound of the present invention, wherein G is a benzene ring; X is a NR6; R6 is a C1-C6 alkyl group or a hydrogen atom; n is 2: Q is an oxygen atom; Y is a C3-C6 cycloalkyl group or a CR R R10 ; R8, R9, and R 10 are independently of each other a C1-C6 alkyl group, a C3-C6 alkynyl group, or a hydrogen atom; and A is attached to G at the meta position relative to the oxadiazole ring. [Embodiment 24] The compound of the present invention, wherein G is a benzene ring; X is a NR6; R6 is a C1-C6 alkyl group or a hydrogen atom; n is 2; Q is an oxygen atom; Y is a C3-C6 cycloalkyl group or a CR R R10 ; R8, R9, and R 10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 25] The compound of the present invention, wherein G is a benzene ring; X is a NR6; R6 is a C1-C6 alkyl group or a hydrogen atom; n is 2; Q is an oxygen atom; Y is a C3-C6 cycloalkyl group or a CR R R10 ; R8, R , and R10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to G at the meta position relative to the oxadiazole ring. [Embodiment 26] The compound of the present invention, wherein G is a benzene ring; X is a NR6; R6 is a C1-C6 alkyl group optionally substituted with one or more halogen atoms, a C3-C6 alkynyl group, a C3-C6 cycloalkyl group, or a hydrogen atom; n is 2; Q is an oxygen atom; Y is a C3-C6 cycloalkyl group or a CR R R10 ; R8, R9, and R10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to said benzene ring represented by G at the para position relative to the oxadiazole ring. [Embodiment 27] The compound of the present invention, wherein G is a benzene ring; X is a NR6; R6 is a C1-C6 alkyl group optionally substituted with one or more halogen atoms, a C3-C6 alkynyl group, a C3-C6 cycloalkyl group, or a hydrogen atom; n is 2; Q is an oxygen atom; Y is a CR R R 10 ; R8, R9, and R10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to said benzene ring represented by G at the para position relative to the oxadiazole ring. [Embodiment 28] The compound of the present invention, wherein G is a benzene ring optionally having one or more fluorine atoms; X is a single bond; n is 2; Q is an oxygen atom; and Y is a NR R 12 . [Embodiment 29] The compound of the present invention, wherein G is a benzene ring optionally having one or more fluorine atoms; X is a single bond; n is 2; Q is an oxygen atom; Y is a NR R12 ; R 1 1 and R12 are independently of each other a C1-C6 alkyl group (wherein said C1-C6 alkyl group may optionally have one or more substituents selected from the group consisting of a halogen atom, a C3-C6 cycloalkyl group, and a C1-C6 alkoxy group), a C3-C6 alkynyl group optionally having one or more halogen atoms, a C3-C6 cy cloalkyl group optionally having one or more halogen atoms, or a hydrogen atom, or R 1 1 and R12 are combined with each other to form a 3 to 6 membered heterocyclic group (wherein said 3 to 6 membered heterocyclic group may optionally have one or more halogen atoms); and A is attached to G at the para position or the meta position relative to the oxadiazole ring. [Embodiment 30] The compound of the present invention, wherein G is a benzene ring optionally having one or more fluorine atoms; X is a single bond; n is 2; Q is an oxygen atom; Y is a NR R12 ; R 1 1 and R12 are independently of each other a C1-C6 alkyl group (wherein said C1-C6 alkyl group may optionally have one or more substituents selected from the group consisting of a C3-C6 cycloalkyl group and a C1-C6 alkoxy group), a C3-C6 alkynyl group, a C3-C6 cycloalkyl group, or a hydrogen atom, or R 1 1 and R12 are combined with each other to form a 3 to 6 membered heterocyclic group (wherein said 3 to 6 membered heterocyclic group may optionally have one or more halogen atoms); A is attached to G at the para position or the meta position relative to the oxadiazole ring. [Embodiment 31] The compound of the present invention, wherein G is a benzene ring optionally having one or more fluorine atoms; X is a single bond; n is 2; Q is an oxygen atom; Y is a NR R12 ; R 1 1 and R12 are independently of each other a C1-C6 alkyl group (wherein said C1-C6 alkyl group may optionally have one or more substituents selected from the group consisting of a C3-C6 cycloalkyl group and a C1-C6 alkoxy group), a C3-C6 alkynyl group, a C3-C6 cycloalkyl group, or a hydrogen atom, or R 1 1 and R12 are combined with each other to form a 3 to 6 membered heterocyclic group (wherein said 3 to 6 membered heterocyclic group may optionally have one or more halogen atoms); and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 32] The compound of the present invention, wherein G is a benzene ring optionally having one or more fluorine atoms; X is a single bond; n is 2; Q is an oxygen atom; Y is a NR R 12 ; R 1 1 and R 12 are independently of each other a C1-C6 alkyl group (wherein said C1-C6 alkyl group may optionally have one or more substituents selected from the group consisting of a C3-C6 cycloalkyl group and a C1-C6 alkoxy group), a C3-C6 alkynyl group, a C3-C6 cycloalkyl group, or a hydrogen atom, or R 1 1 and R 12 are combined with each other to form a 3 to 6 membered heterocyclic group (wherein said 3 to 6 membered heterocyclic group may optionally have one or more halogen atoms); and A is attached to G at the meta position relative to the oxadiazole ring. [Embodiment 33] The compound of the present invention, wherein G is a benzene ring optionally having one or more fluorine atoms; X is a single bond; n is 2; Q is an oxygen atom; Y is a NR R 12 ; R 1 1 and R 12 are independently of each other a C1-C6 alkyl group (wherein said C1-C6 alkyl group may optionally have one or more substituents selected from the group consisting of a C3-C6 cycloalkyl group and a C1-C6 alkoxy group), a C3-C6 alkynyl group, a C3-C6 cycloalkyl group, or a hydrogen atom, or R 1 1 and R 12 are combined with each other to form a 3 to 6 membered heterocyclic group; and A is attached to G at the para position or the meta position relative to the oxadiazole ring. [Embodiment 34] The compound of the present invention, wherein G is a benzene ring optionally having one or more fluorine atoms; X is a single bond; n is 2; Q is an oxygen atom; Y is a NR R 12 ; R 1 1 and R 12 are independently of each other a C1-C6 alkyl group (wherein said C1-C6 alkyl group may optionally have one or more substituents selected from the group consisting of a C3-C6 cycloalkyl group and a C1-C6 alkoxy group), a C3-C6 alkynyl group, a C3-C6 cycloalkyl group, or a hydrogen atom, or R 1 1 and R 12 are combined with each other to form a 3 to 6 membered heterocyclic group; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 35] The compound of the present invention, wherein G is a benzene ring optionally having one or more fluorine atoms; X is a single bond; n is 2; Q is an oxygen atom; Y is a NR R12 ; R 1 1 and R12 are independently of each other a C1-C6 alkyl group (wherein said C1-C6 alkyl group may optionally have one or more substituents selected from the group consisting of a C3-C6 cycloalkyl group and a C1-C6 alkoxy group), a C3-C6 alkynyl group, a C3-C6 cycloalkyl group, or a hydrogen atom, or R 1 1 and R12 are combined with each other to form a 3 to 6 membered heterocyclic group; and A is attached to G at the meta position relative to the oxadiazole ring. [Embodiment 36] The compound of the present invention, wherein G is a benzene ring optionally having one or more fluorine atoms; X is a single bond; n is 2; Q is an oxygen atom; Y is a NR R 12 ; R 1 1 and R 12 are independently of each other a C1-C6 alkyl group (wherein said C1-C6 alkyl group may optionally have one or more substituents selected from the group consisting of a C3-C6 cycloalkyl group and a C1-C6 alkoxy group), a C3-C6 alkynyl group, a C3-C6 cycloalkyl group, or a hydrogen atom; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 37] The compound of the present invention, wherein G is a benzene ring; X is a single bond; n is 2; Q is an oxygen atom; Y is a NR R 12 ; R 1 1 and R 12 are independently of each other a C1-C6 alkyl group (wherein said C1-C6 alkyl group may optionally have one or more substituents selected from the group consisting of a C3-C6 cycloalkyl group and a C1-C6 alkoxy group), a C3-C6 alkynyl group, a C3-C6 cycloalkyl group, or a hydrogen atom; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 38] The compound of the present invention, wherein G is a benzene ring optionally having one or more fluorine atoms; X is a single bond; n is 2; Q is an oxygen atom; Y is a NR R12 ; R 1 1 and R12 are independently of each other a C1-C6 alkyl group optionally having one or more C3-C6 cycloalkyl groups, or a hydrogen atom, or R 1 1 and R 12 are combined with each other to form a 3 to 6 membered heterocyclic group; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 39] The compound of the present invention, wherein G is a benzene ring; X is a single bond; n is 2; Q is an oxygen atom; Y is a NR R12 ; R 1 1 and R12 are independently of each other a C1-C6 alkyl group optionally having one or more C3-C6 cycloalkyl groups, or a hydrogen atom, or R 1 1 and R 12 are combined with each other to form a 3 to 6 membered heterocyclic group; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 40] The compound of the present invention, wherein G is a benzene ring optionally having one or more fluorine atoms; X is a single bond; n is 2; Q is an oxygen atom; Y is a NR R 12 ; R 1 1 and R 12 are independently of each other a C1-C6 alkyl group optionally having one or more C3-C6 cycloalkyl groups, or a hydrogen atom; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 41] The compound of the present invention, wherein G is a benzene ring; X is a single bond; n is 2; Q is an oxygen atom; Y is a NR R 12 ; R 1 1 and R 12 are independently of each other a C1-C6 alkyl group optionally having one or more C3-C6 cycloalkyl groups, or a hydrogen atom; and A is attached to G at the para position relative to the oxadiazole ring. [0033] [Embodiment 42] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom; G is a benzene ring; R2 and R3 are each a hydrogen atom; Y is a CR R R10 ; R8, R9, and R 10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to G at the para position or the meta position relative to the oxadiazole ring. [Embodiment 43] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom; G is a benzene ring; R2 and R3 are each a hydrogen atom; Y is a CR R R10 ; R8, R9, and R 10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 44] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom; G is a benzene ring; R2 and R3 are each a hydrogen atom; Y is a CR R R10 ; R8, R9, and R 10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to G at the meta position relative to the oxadiazole ring. [0034] [Embodiment 45] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom; G is a benzene ring or a pyridine ring; Y is a CR R R10 ; R8, R9, and R 10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 46] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom; G is a pyridine ring; Y is a CR R R 10 ; R8, R9, and R10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 47] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom, a NH, or a N-CN; G is a pyridine ring; Y is a CR R R10 ; R8, R9, and R 10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 48] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom, a NH, or a N-CN; G is a pyridine ring; Y is a CR R R10 ; R8, R9, and R 10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to G at the meta position relative to the oxadiazole ring. [Embodiment 49] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom; G is a pyridine ring; Y is a CR R R10 ; R8, R9, and R 10 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to G at the meta position relative to the oxadiazole ring. [Embodiment 50] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom; n is 2; G is a benzene ring; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 51] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom; n is 2; G is a benzene ring; Y is a CR R R 10 ; and A is attached to G at the para position relative to the oxadiazole ring. [Embodiment 52] The compound of the present invention, wherein X is a single bond; Q is an oxygen atom; G is a benzene ring; Y is a CR R R 10 ; R8, R , and R10 are each a hydrogen atom; and A is attached to G at the para position relative to the oxadiazole ring. [0036] [Embodiment 53] The compound according to any one of Embodiments 1 to 52, wherein A is a single bond; and m is 0. [Embodiment 54] The compound according to any one of Embodiments 1 to 52, wherein A is an oxygen atom. [Embodiment 55] The compound according to any one of Embodiments 1 to 52, wherein; A is an oxygen atom; and m is 1 or 2. [Embodiment 56] The compound according to any one of Embodiments 1 to 52, wherein; A is an oxygen atom; and m is 0. [0037] Next, the process for preparing the compound of the present invention is described. [0038] The compound of the present invention can be prepared, for example, according to the following processes. [0039] Process A The compound of the present invention may be prepared by reacting the compound represented by formula (Al) (hereinafter referred to as "Compound (Al)") with trifluoroacetic anhydride in the presence of a base. [Chem.ll]

(wherein the symbols are the same as defined above.) The reaction is usually carried out in the presence of a solvent. Examples of the solvent to be used in the reaction include hydrocarbons such as n-hexane, cyclohexane, toluene, and xylene (hereinafter collectively referred to as "hydrocarbons"); ethers such as diethyl ether, tetrahydrofuran, 1,4-dioxane, ethylene glycol dimethyl ether, methyl tert-butyl ether, and diisopropylether (hereinafter collectively referred to as "ethers"); halogenated hydrocarbons such as chloroform, dichloromethane, and chlorobenzene (hereinafter collectively referred to as "halogenated hydrocarbons"); amides such as N,N-dimethylformamide, l,3-dimethyl-2-imidazolidinone, and N-methylpyrrolidone (hereinafter collectively referred to as "amides"); esters such as ethyl acetate and methyl acetate (hereinafter collectively referred to as "esters"); sulfoxide such as dimethyl sulfoxide (hereinafter collectively referred to as "sulfoxides"); nitriles such as acetonitrile and propionitrile (hereinafter collectively referred to as "nitriles"); water; and mixed solvents thereof. Examples of the base to be used in the reaction include organic bases such as triethylamine, pyridine, 2,2'-bipyridine, and diazabicycloundecene (hereinafter col lectively referred to as "organic bases"); carbonates such as sodium carbonate and potassium carbonate (hereinafter collectively referred to as "carbonates"); and hydrogen carbonates such as sodium hydrogen carbonate and potassium hydrogen carbonate (hereinafter collectively referred to as "hydrogen carbonates"). In the reaction, 1 to 10 mols of the trifluoroacetic anhydride is usually used, and 1 to 10 mols of the base is usually used, per mol of the Compound (Al). The reaction temperature of the reaction is usually within a range of -20 to 150°C. The reaction period of the reaction is usually within a range of 0.1 to 120 hours. When the reaction is completed, the reaction mixtures are mixed with water and then extracted with organic solvent(s), and the organic layers are worked up (for example, dried or concentrated) to isolate the compound of the present invention. Alternatively, to the reaction mixtures is added water, and the resulting precipitates are collected by filtration, to isolate the compound of the present invention. Process B The compound represented by formula (IB) (hereinafter referred to as "Compound (IB)") or the compound represented by formula (1C) (hereinafter referred to as "Compound (1C)") may be prepared by reacting the compound represented by formula (1A) (hereinafter referred to as "Compound (1A)") with an oxidizing agent. [Chem.12]

(wherein the symbols are the same as defined above.) The reaction is usually carried out in the presence of a solvent. Examples of the solvent to be used in the reaction include hydrocarbons; ethers; halogenated hydrocarbons; amides; esters; sulfoxides; nitriles; alcohols such as methanol and ethanol (hereinafter collectively referred to as "alcohols"); water; and mixed solvents thereof. Examples of the oxidizing agent to be used in the reaction include hydrogen peroxide, m-chloroperbenzoic acid, sodium periodate, and potassium periodate. A base may be added to the reaction. Examples of the base include alkali metal carbonates such as sodium carbonate and potassium carbonate. An additive may be added to the reaction. Examples of the additive include trifluoroacetic acid and ruthenium trichloride hydrate. In the reaction for preparing the Compound (IB), 1 to 1.9 mols of the oxidizing agent is usually used, 1 to 10 mols of the base is usually used, and 0.01 to 10 mols of the additive is usually used, per mol of the Compound (1A). In the reaction for preparing the Compound (1C), 2 to 10 mols of the oxidizing agent is usually used, 1 to 10 mols of the base is usually used, and 0.01 to 10 mols of the additive is usually used, per mol of the Compound (1A). The reaction temperature of the reaction is usually within a range of -20 to 150°C. The reaction period of the reaction is usually within a range of 0.1 to 120 hours. When the reaction is completed, the reaction mixtures are mixed with water and then extracted with organic solvent(s), and the organic layers are worked up (for example, dried or concentrated) to isolate the Compound (IB) or Compound (1C). Also, the resulting compounds may be further purified by, for example, silica gel chro matography. Process C The compound represented by formula (IE) may be prepared by reacting the compound represented by formula (ID) with an oxidizing agent. The reaction is carried out according to the process described in the Process B. [Chem.13]

7 7 7 (wherein Q is a CN, a N0 2, a C(0)R , a C(0)OR , or a S(0) 2R ; and the other symbols are the same as defined above.) [0042] Process D The compound represented by formula (1D1) (hereinafter referred to as "Compound (1D1)") may be prepared by reacting the Compound (1A) with cyanamide in the presence of an additive. [Chem.14]

(wherein the symbols are the same as defined above.) The reaction is usually carried out in the presence of a solvent. Examples of the solvent to be used in the reaction include hydrocarbons, ethers, halogenated h y drocarbons, amides, esters, sulfoxides, nitriles, alcohols, water, and mixed solvents thereof. Examples of the additive to be used in the reaction include iodobenzene diacetate and bis(trifluoroacetoxy)phenyl iodide. In the reaction, 1 to 10 mols of the cyanamide is usually used, and 1 to 10 mols of the additive is usually used, per mol of the Compound (1A). The reaction temperature of the reaction is usually within a range of -20 to 150°C. The reaction period of the reaction is usually within a range of 0.1 to 120 hours. When the reaction is completed, the reaction mixtures are mixed with water and then extracted with organic solvent(s), and the organic layers are worked up (for example, dried or concentrated) to isolate the Compound (1D1). [0043] Process E The compound represented by formula (IF) (hereinafter referred to as "Compound (IF)") may be prepared by reacting the Compound (IB) with an aminating agent in the presence of an additive. [Chem.15]

(wherein the symbols are the same as defined above.) The reaction is usually carried out in the presence of a solvent. Examples of the solvent to be used in the reaction include hydrocarbons, ethers, halogenated hydrocarbons, amides, esters, nitriles, alcohols, water, and mixed solvents thereof. Examples of the aminating agent to be used in the reaction include ammonia, ammonium formate, and ammonium carbamate. Examples of the additive to be used in the reaction include iodobenzene diacetate and bis(trifluoroacetoxy)phenyl iodide. In the reaction, 1 to 10 mols of the aminating agent is usually used, and 1 to 10 mols of the additive is usually used, per mol of the Compound (IB). The reaction temperature of the reaction is usually within a range of -20 to 150°C. The reaction period of the reaction is usually within a range of 0.1 to 120 hours. When the reaction is completed, the reaction mixtures are worked up (for example, concentrated) to isolate the Compound (IF). Process F The compound represented by formula (1G2) (hereinafter referred to as "Compound (1G2)") may be prepared by reacting the compound represented by formula (1G1) (hereinafter referred to as "Compound (1G1)") with the compound represented by formula (Ml 1) (hereinafter referred to as "Compound (Ml 1)") in the presence of a base. [Chem.16]

(wherein X 1 is a leaving group such as a chlorine atom, a bromine atom, an iodine atom, a methanesulfonyloxy group, and a trifluoromethanesulfonyloxy group; and the other symbols are the same as defined above.) The reaction is usually carried out in the presence of a solvent. Examples of the solvent to be used in the reaction include hydrocarbons, ethers, halogenated h y drocarbons, amides, esters, nitriles, alcohols, water, and mixed solvents thereof. Examples of the base to be used in the reaction include organic bases; carbonates; hydrogen carbonates; and metal hydride reagents such as sodium hydride, potassium hydride, and lithium hydride (hereinafter referred to as "metal hydride reagents"). In the reaction, 1 to 10 mols of the Compound (Ml 1) is usually used, and 1 to 10 mols of the base is usually used, per mol of the Compound (1G1). The reaction temperature of the reaction is usually within a range of -20 to 150°C. The reaction period of the reaction is usually within a range of 0.1 to 120 hours. When the reaction is completed, the reaction mixtures are mixed with water and then extracted with organic solvent(s), and the organic layers are worked up (for example, dried or concentrated) to isolate the Compound (1G2). The compound (Ml 1) is known, or may be prepared according to a known process. Process G The compound represented by formula (1A1) (hereinafter referred to as "Compound (1A1)") may be prepared by reacting the compound represented by formula (A7) (hereinafter referred to as "Compound (A7)") with the compound represented by formula (M12) (hereinafter referred to as "Compound (M12)) in the presence of an azo compound. [Chem.17]

(wherein the symbols are the same as defined above.) The reaction is usually carried out in the presence of a solvent. Examples of the solvent to be used in the reaction include hydrocarbons, ethers, halogenated h y drocarbons, esters, and mixed solvents thereof. Examples of the azo compound to be used in the reaction include diethyl azodicar- boxylate and bis(2-methoxyethyl)diazene-l,2-dicarboxylate. In the reaction, 1 to 10 mols of the compound (Ml 2) is usually used, and 1 to 10 mols of the azo compound is usually used, per mol of the Compound (A7). The reaction temperature of the reaction is usually within a range of -20 to 150°C. The reaction period of the reaction is usually within a range of 0.1 to 120 hours. When the reaction is completed, the reaction mixtures are mixed with water and then extracted with organic solvent(s), and the organic layers are worked up (for example, dried or concentrated) to isolate the Compound (1A1). The Compound (A7) may be prepared according to the process described in JP 63-162680 A. The compound (M12) is known, or may be prepared according to a known process. Reference process A The Compound (Al) may be prepared by reacting the compound represented by formula (A2) (hereinafter referred to as "Compound (A2)") with hydroxylamine. Chem.18]

(A2) (A1) (wherein the symbols are the same as defined above.) The reaction is carried out according to, for example, the process described in WO 2009/081891 pamphlet. Reference process B The Compound (A2) may be prepared by oxidizing the compound represented by formula (A3) (hereinafter referred to as "Compound (A3)"). [Chem.19]

Reference process C The compound represented by formula (A2-1) (hereinafter referred to as "Compound (A2-1)") may be prepared by reacting the compound represented by formula (A4) (hereinafter referred to as "Compound (A4)") with the compound represented by formula (Ml) (hereinafter referred to as "Compound (Ml)"). [Chem.20] o

(A4) (A2-1)

(wherein Y 101 is a C1-C6 alkyl group; M is an alkali metal such as potassium and sodium; and the other symbols are the same as defined above.) The reaction is usually carried out in the presence of a solvent. Examples of the solvent to be used in the reaction include hydrocarbons, ethers, halogenated hydrocarbons, amides, esters, nitriles, alcohols, water, and mixed solvents thereof. In the reaction, 1 to 10 mols of the compound (Ml) is usually used per mol of the Compound (A4). The reaction temperature of the reaction is usually within a range of -20 to 150°C. The reaction period of the reaction is usually within a range of 0.1 to 120 hours. When the reaction is completed, the reaction mixtures are worked up (for example, extracted or concentrated) to isolate the Compound (A2-1). The Compound (A4) may be prepared according to the process described in WO 2012/058134 pamphlet. Reference process D The compound represented by formula (A2-2) (hereinafter referred to as "Compound (A2-2)") may be prepared by reacting the compound represented by formula (A5) (hereinafter referred to as "Compound (A5)") with the compound represented by formula (M2) (hereinafter referred to as "Compound (M2)") in the presence of a base. [Chem.21]

(A5) (A2-2) (wherein the symbols are the same as defined above.) The reaction is carried out according to the process described in WO 2015/004282 pamphlet. The Compound (A5) may be prepared according to the process described in WO 2011/142356 pamphlet. The compound (M2) is known, or may be prepared according to a known process. Reference process E The compound represented by formula (A2-3) (hereinafter referred to as "Compound (A2-3)") may be prepared by reacting the compound represented by formula (A6) (hereinafter referred to as "Compound (A6)") with the compound represented by formula (M3) (hereinafter referred to as "Compound (M3)") in the presence of a base. [Chem.22]

(A6) (A2-3)

(wherein Y 1 1 is a NR R 12 or a OR 13 ; and the other symbols are the same as defined above.) The reaction is carried out according to the process described in WO 2013/008162 pamphlet. The Compound (A6) may be prepared according to the process described in WO 2007/140317 pamphlet. The compound (M3) is known, or may be prepared according to a known process. Reference process F The compound represented by formula (A3-1) (hereinafter referred to as "Compound (A3-1)") may be prepared by reacting the compound represented by formula (A4) (hereinafter referred to as "Compound (A4)") with the compound represented by formula (M4) (hereinafter referred to as "Compound (M4)"). [Chem.23]

(wherein the symbols are the same as defined above.) The reaction may be carried out according to the process described in Journal of the Chemical Society, 1948, pl501-1506. The compound (M4) is known, or may be prepared according to a known process. Reference process G The compound represented by formula (A3-2) (hereinafter referred to as "Compound (A3-2)") may be prepared by reacting the compound represented by formula (A8) (hereinafter referred to as "Compound (A8)") with the compound represented by formula (Ml 3) (hereinafter referred to as "Compound (Ml 3)") in the presence of a base. [Chem.24]

(A8) (A3-2) (wherein the symbols are the same as defined above.) The reaction may be carried out according to the process described in Process F. The Compound (A8) may be prepared according to the process described in Bioorganic & Medicinal Chemistry Letters, 2016, 26(3), p757-760. [0053] The control agent of the present invention is usually prepared by mixing the compound of the present invention with a solid carrier, a liquid carrier, a surfactant, and/or the others, and if necessary, adding auxiliary agents for formulation such as binders, dispersants, and stabilizers, to formulate into wettable powders, granular wettable powders, flowables, granules, dry flowables, emulsifiable concentrates, aqueous solutions, oil solutions, smoking agents, aerosols, microcapsules, poison baits, resin formulations, shampoo formulations, paste-like formulations, foams, carbon dioxide formulations, tablets, or the others. Such formulations may be processed into mosquito repellent coils, electric mosquito repellent mats, liquid mosquito for mulations, smoking agents, fumigants, sheet formulations, spot-on formulations, or formulations for oral treatment. Such formulations comprise usually 0.1 to 99% by weight, and preferably 0.2 to 90% by weight of the compound of the present invention. [0054] Examples of the solid carrier include fine powders or granules of clays (for example, kaolin, diatomaceous earth, Fubasami clay, bentonite, or acid white clay), synthetic hydrated silicon oxides, talcs, other inorganic minerals (for example, sericite, quartz powder, sulfur powder, active carbon, or calcium carbonate), and the others. Examples of the liquid carrier include water; alcohols; ketones (for example, acetone, methylethylketone, or cyclohexanone); aromatic hydrocarbons (for example, a benzene, toluene, xylene, ethyl benzene, or methylnaphthalene); aliphatic h y drocarbons (for example, n-hexane or kerosene); esters; nitriles; ethers; amides; halogenated hydrocarbons; and the others. [0055] Examples of the surfactant include alkyl sulfates, alkyl sulfonates, alkyl aryl sulfonates, alkyl aryl ethers and polyoxyethylated compounds thereof, polyoxyethylene glycol ethers, polyhydric alcohol esters, and sugar alcohol derivatives. [0056] Examples of the other auxiliary agents for formulation include a binder, a dispersant, and a stabilizer. Specific examples include casein, gelatin, polysaccharides (for example, starch, gum arabic, cellulose derivatives, or alginic acid), lignin derivatives, bentonite, saccharides, water-soluble synthetic polymers (for example, polyvinyl alcohol, polyvinyl pyrrolidone, or polyacrylic acids), acidic isopropyl phosphate, 2,6-di-tert-butyl-4-methylphenol, a mixture of 2-tert-butyl-4-methoxyphenol and 3-tert-butyl-4-methoxyphenol, vegetable oils, mineral oils, and fatty acids and esters thereof. [0057] Also, the compound of the present invention may be mixed with an oil such as mineral oil and vegetable oil, a surfactant, or the others to use for controlling pests. Examples of the oil or surfactant to be mixed with the compound of the present invention include Nimbus (registered trademark), Assist (registered trademark), Aureo (registered trademark), Iharol (registered trademark), Silwet L-77 (registered trademark), BreakThru (registered trademark), Sundancell (registered trademark), Induce (registered trademark), Penetrator (registered trademark), AgriDex (registered trademark), Lutensol A8 (registered trademark), NP-7 (registered trademark), Triton (registered trademark), Nufilm (registered trademark), Emulgator NP7 (registered trademark), Emulad (registered trademark), TRITON X 45 (registered trademark), AGRAL 90 (registered trademark), AGROTIN (registered trademark), ARPON (registered trademark), EnSpray N (registered trademark), and BANOLE (registered trademark). [0058] Examples of base material of the resin formulation include polyvinyl chloride polymers, polyurethane, and the others, and a plasticizer such as phthalate esters (for example, dimethyl phthalate or dioctyl phthalate), adipic acid esters, and stearic acid may be added to these base materials, if necessary. The resin formulation can be prepared by mixing the compound of the present invention with the above-mentioned base material, kneading the mixture in a conventional kneading apparatus, followed by molding it by injection molding, extrusion molding, pressure molding, or the like. The resultant resin formulation can be subjected to further molding, cutting procedure, or the like, if necessary, to be processed into shapes such as a plate, film, tape, net, and string shape. These resin formulations can be processed into animal collars, animal ear tags, sheet products, trap strings, gardening supports, or other products. Examples of a base material for the poison baits include bait ingredients such as grain powder, vegetable oil, saccharide, and crystalline cellulose, and if necessary, with addition of antioxidants such as dibutylhydroxytoluene and nordihydroguaiaretic acid, preservatives such as dehydroacetic acid, accidental ingestion inhibitors for children and pets such as a chili powder, insect attraction fragrances such as cheese flavor, onion flavor, and peanut oil, or the other ingredient. [0059] The application dose of the control agent of the present invention may be varied depending on a climate condition, a dosage form, an application period, an application method, an application site, a disease to be controlled, an insect to be controlled, a kind of crop to be applied, and the like. The amount of the compound of the present invention in the control agent of the present invention is usually within the range of 1 to 500 g, and preferably 2 to 200 g, per 1000 m2. The emulsifiable concentrates, the wettable powders, or suspensions etc. are usually applied by diluting them with water, and then spreading them. In this case, the concentration of the compound of the present invention after dilution is usually 0.0005 to 2% by weight, and preferably 0.005 to 2% by weight. The dusts or the granules, etc., are usually applied as itself without diluting them. [0060] The method for applying the control agent of the present invention is not limited to a specific method as long as the compound of the present invention can be applied. Examples of the method include an application to a plant body such as a foliar ap plication, an application to a cultivation area of plant such as a soil treatment, an ap plication to seeds such as a seed disinfection, and an application to harmful arthropods. Also, a resin formulation processed into sheet shape or string shape may be wrapped around a crop, stretched near a crop, spread on a plant foot soil, or the like to apply the control agent of the present invention. When the control agent of the present invention is applied to a foliage of a plant or a soil for cultivating a plant, the amount of the compound of the present invention is usually within the range of 1 to 500 g, per 1000 m2 of the soil. When the control agent of the present invention is applied to seeds, the amount of the compound of the present invention in the control agent of the present invention is usually within the range of 0.001 to 100 g, and preferably 0.01 to 50 g per 1 Kg of seeds. The emulsifiable concentrates, the wettable powders or the flowables, etc., are usually applied by diluting them with water, and then spreading them. In this case, the concentration of the compound of the present invention is usually within the range of 0.0005 to 2% by weight. The dusts or the granules, etc., are usually applied as itself without diluting them. [0061] When the control agent of the present invention is used to control harmful arthropods that live inside a house, the application dose as an amount of the compound of the present invention is usually within a range from 0.01 to 1,000 mg per 1 m2 of an area to be treated, in the case of using it on a planar area. In the case of using it spatially, the application dose as an amount of the compound of the present invention is usually within a range from 0.01 to 500 mg per 1 m3 of the space to be treated. When the control agent of the present invention is formulated into emulsifiable concentrates, wettable powders, flowables, or the others, such formulations are usually applied after diluting it with water in such a way that the concentration of the compound of the present invention is within a range from 0.1 to 10,000 ppm, and then sparging it. In the case of being formulated into oil solutions, aerosols, smoking agents, poison baits, or the others, such formulations are used as itself without diluting it. [0062] When the control agent of the present invention is used for controlling external parasites of livestock such as cows, horses, pigs, sheep, goats, and chickens, and small animals such as dogs, cats, rats, and mice, the control agent of the present invention can be applied to the animals by a known method in the veterinary field. Specifically, when systemic control is intended, the control agent of the present invention is ad ministered to the animals as a tablet, a mixture with feed, or a suppository, or by injection (including intramuscular, subcutaneous, intravenous, and intraperitoneal in jections), or the others. On the other hand, when non-systemic control is intended, the control agent of the present invention is applied to the animals by means of spraying of an oil solution or aqueous solution etc., pour-on or spot-on treatment, or washing of the animal with a shampoo formulation, or by putting a collar or ear tag made of the resin formulations to the animal. In the case of administering to an animal body of the livestock or small animals, the dose of the compound of the present invention is usually within a range from 0.1 to 1,000 mg per 1 kg of an animal body weight. [0063] Also, the control agent of the present invention may be used as an agent for con trolling plant diseases in croplands such as fields, paddy fields, grasses, and orchards. The compound of the present invention can control cropland diseases in the croplands etc. for cultivating the following "plant(s)" etc. Further, the compound of the present invention can control harmful arthropods in the croplands. [0064] Crops: corn, rice, wheat, barley, rye, oat, sorghum, cotton, the soybeans, peanut, buckwheat, beet, rapeseed, sunflower, sugar cane, tobacco, and the others; Vegetables: solanaceous vegetables (for example, eggplant, tomato, pimento, pepper, or potato), cucurbitaceous vegetables (for example, cucumber, pumpkin, zucchini, water melon, or melon), cruciferous vegetables (for example, Japanese radish, white turnip, horseradish, kohlrabi, Chinese cabbage, cabbage, leaf mustard, broccoli, or cauliflower), asteraceous vegetables (for example, burdock, crown daisy, artichoke, or lettuce), liliaceous vegetables (for example, welsh onion, onion, garlic, or asparagus), ammiaceous vegetables (for example, carrot, parsley, celery, or parsnip), chenopo- diaceous vegetables (for example, spinach or Swiss chard), lamiaceous vegetables (for example, perilla, mint, or basil), strawberry, sweet potato, glutinous yam, eddoe, and the others; Flowers; Foliage plants; Fruits: pomaceous fruits (for example, apple, pear, Japanese pear, Chinese quince, or quince), stone fleshy fruits (for example, peach, plum, nectarine, Japanese apricot (Prunus mume), cherry fruit, apricot, or prune), citrus fruits (for example, Citrus unshiu, orange, lemon, lime, or grapefruit), nuts (for example, chestnuts, walnuts, hazelnuts, almond, pistachio, cashew nuts, or macadamia nuts), berry fruits (for example, blueberry, cranberry, blackberry, or raspberry), grapes, Japanese persimmon, olive, Japanese plum, banana, coffee, date palm, coconuts, and the others; and Trees other than fruit trees: tea, mulberry, flowering plants, roadside trees (for example, ash, birch, dogwood, eucalyptus, ginkgo (ginkgo biloba), lilac, maple, oak (quercus), poplar, Judas tree, Formosan gum (Liquidambar formosana), plane tree, zelkova, Japanese arborvitae (Thuja standishii), fir wood, hemlock, juniper, pinus, picea, or yew (Taxus cuspidate)), and the others. [0065] The above-mentioned "plant(s)" may include genetically modified plant(s). [0066] Examples of the pest which may be controlled by the compound of the present invention include plant pathogens such as filamentous fungi and harmful arthropods, and more specifically include, but are not limited to, the followings. [0067] Examples of the plant pathogens include the followings. Rice diseases: blast (Magnaporthe grisea), brown spot (Cochliobolus miyabeanus), sheath blight (Rhizoctonia solani), bakanae disease (Gibberella fujikuroi), and downy mildew (Sclerophthora macrospora); Wheat diseases: powdery mildew (Erysiphe graminis), fusarium Head blight (Fusarium graminearum, F. avenaceum, F. culmorum, Microdochium nivale), rust (Puccinia striiformis, P. graminis, P. recondita), snow mold (Micronectriella nivale, M. majus), typhula snow blight (Typhula sp.), loose smut (Ustilago tritici), stinking smut (Tilletia caries, T. controversa), eyespot (Pseudocercosporella herpotrichoides), Septoria leaf blotch (Septoria tritici), glume blotch (Stagonospora nodorum), tan spot (Pyrenophora tritici-repentis), damping-off caused by rhizoctonia fungus (Rhizoctonia solani), and damping-off (Gaeumannomyces graminis); Barley diseases: powdery mildew (Erysiphe graminis), loose smut (Fusarium graminearum, F. avenaceum, F. culmorum, Microdochium nivale), rust (Puccinia striiformis, P. graminis, P. hordei), loose smut (Ustilago nuda), scald (Rhynchosporium secalis), net blotch (Pyrenophora teres), spot blotch (Cochliobolus sativus), leaf stripe (Pyrenophora graminea), Ramuraria disease (Ramularia collo-cygni), and damping-off caused by rhizoctonia fungus (Rhizoctonia solani); Corn diseases: rust (Puccinia sorghi), southern rust (Puccinia polysora), northern leaf blight (Setosphaeria turcica), tropical rust (Physopella zeae), southern leaf blight (Cochliobolus heterostrophus), anthracnose (CoUetotrichum graminicola), gray leaf spot (Cercospora zeae-maydis), eyespot (Kabatiella zeae), Faeosufa area leaf spot disease (Phaeosphaeria maydis), Diplodia disease (Stenocarpella maydis, Stenocarpella macrospora), stalk rot disease (Fusarium graminearum, Fusarium verticilioides, Col- letotrichum graminicola), and smut (Ustilago maydis); Cotton diseases: anthracnose (CoUetotrichum gossypii), Areolate mildew (Ramuraria areola), leaf spot (Alternaria macrospora, A. gossypii), and Black root rot caused by Thielaviopsis fungus (Thielaviopsis basicola); Coffee diseases: rust (Hemileia vastatrix) and leaf spot (Cercospora coffeicola); Rapeseed diseases: sclerotinia rot (Sclerotinia sclerotiorum), alternaria leaf spot (Alternaria brassicae), and root rot (Phoma lingam); Sugarcane diseases: rust (Puccinia melanocephela, Puccinia kuehnii), and smut (Ustilago scitaminea); Sunflower diseases: rust (Puccinia helianthi) and downy mildew (Plasmopara halstedii); Citrus diseases: melanose (Diaporthe citri), scab (Elsinoe fawcetti), fruit rot (Penicillium digitatum, P. italicum), and Phytophthora disease (Phytophthora parasitica, Phytophthora citrophthora); Apple diseases: blossom blight (Monilinia mali), canker (Valsa ceratosperma), powdery mildew (Podosphaera leucotricha), Alternaria leaf spot (Alternaria alternata apple pathotype), scab (Venturia inaequalis), anthracnose (Glomerella cingulata), blotch (Diplocarpon mali), ring rot (Botryosphaeria berengeriana), and crown rot (Phytophthora cactorum); Pear diseases: scab (Venturia nashicola, V. pirina), black spot (Alternaria alternata Japanese pear pathotype), and rust (Gymnosporangium haraeanum); Peach diseases: brown rot (Monilinia fructicola), scab (Cladosporium carpophilum), and Phomopsis rot (Phomopsis sp.); Grapes diseases: anthracnose (Elsinoe ampelina), ripe rot (Glomerella cingulata), powdery mildew (Uncinula necator), rust (Phakopsora ampelopsidis), black rot (Guignardia bidwellii), downy mildew (Plasmopara viticola); Diseases of Japanese persimmon: anthracnose (Gloeosporium kaki) and leaf spot (Cercospora kaki, Mycosphaerella nawae); Diseases of Cucurbitaceae: anthracnose (CoUetotrichum lagenarium), powdery mildew (Sphaerotheca fuliginea), gummy stem blight (Didymella bryoniae), corynespora leaf spot (Corynespora cassiicola), Fusarium wilt (Fusarium oxysporum), downy mildew (Pseudoperonospora cubensis), Phytophthora rot (Phytophthora sp.), and damping-off (Pythium sp.); Tomato diseases: early blight (Alternaria solani), leaf mold (Cladosporium fulvum), cercospora leaf mold (Pseudocercospora fuligena), late blight (Phytophthora infestans), and powdery mildew (Leveillula taurica); Eggplant disease: brown spot (Phomopsis vexans) and powdery mildew (Erysiphe ci- choracearum); Diseases of brassica family: Alternaria leaf spot (Alternaria japonica), white spot (Cercosporella brassicae), clubroot (Plasmodiophora brassicae), and downy mildew (Peronospora parasitica); Welsh onion diseases: rust (Puccinia allii); Soybean diseases: purple stain (Cercospora kikuchii), Sphaceloma scad (Elsinoe glycines), pod and stem blight (Diaporthe phaseolorum var. sojae), rust (Phakopsora pachyrhizi), target spot (Corynespora cassiicola), anthracnose (Colletotrithum glycines, C. truncatum), Rhizoctonia rot (Rhizoctonia solani), septoria brown spot (Septoria glycines), Cercospora leaf spot (Cercospora sojina), sclerotinia rot (Sclerotinia scle rotiorum), powdery mildew (Microsphaera diffusa), phytophthora root and stem rot (Phytophthora sojae), downy mildew (Peronospora manshurica), and sudden death syndrome (Fusarium virguliforme); Kidney bean diseases: stem rot (Sclerotinia sclerotiorum), rust (Uromyces appen- diculatus), angular leaf spot (Phaeoisariopsis griseola), and anthracnose (CoUetotrichum lindemuthianum); Peanut diseases: leaf spot (Cercospora personata), brown leaf spot (Cercospora arachidicola), and southern blight (Sclerotium rolfsii); Garden pea diseases: powdery mildew (Erysiphe pisi); Potato diseases: early blight (Alternaria solani), late blight (Phytophthora infestans), pink rot (Phytophthora erythroseptica), powdery scab (Spongospora subterranea f. sp. subterranea), and Verticillium wilt (Verticillium albo-atrum, V. dahliae, V. ni- grescens); Strawberry diseases: powdery mildew (Sphaerotheca humuli); Tea diseases: net blister blight (Exobasidium reticulatum), white scab (Elsinoe leucospila), gray blight (Pestalotiopsis sp.), and anthracnose (CoUetotrichum theae- sinensis); Tabacco diseases: brown spot (Alternaria longipes), anthracnose (CoUetotrichum tabacum), downy mildew (Peronospora tabacina), and black shank (Phytophthora nicotianae); Sugar beet diseases: cercospora leaf spot (Cercospora beticola), leaf blight (Thanatephorus cucumeris), root rot (Thanatephorus cucumeris), and aphanomyces root rot (Aphanomyces cochlioides); Rose diseases: blackspot (Diplocarpon rosae) and powdery mildew (Sphaerotheca pannosa); Chrysanthemum and Asteraceae vegetable diseases: leaf blight (Septoria chrysanthemi-indici) and white rust (Puccinia horiana); Onion diseases: Botrytis leaf blight (Botrytis cinerea, B. byssoidea, B. squamosa), neck rot (Botrytis alii), and small sclerotial (Botrytis squamosa); Various plants diseases: gray mold (Botrytis cinerea) and Sclerotinia rot (Sclerotinia sclerotiorum); Japanese radish diseases: Alternaria leaf spot (Alternaria brassicicola); Turfgrass diseases: dollar spot (Sclerotinia homoeocarpa), and brown patch and large patch (Rhizoctonia solani); Banana diseases: Sigatoka disease (Mycosphaerella fijiensis, Mycosphaerella musicola); Seed diseases or diseases in the early stages of the growth of various plants caused by bacteria of Aspergillus spp., Penicillium spp., Fusarium spp., Gibberella spp., Tricoderma spp., Thielaviopsis spp., Rhizopus spp., Mucor spp., Corticium spp., Phoma spp., Rhizoctonia spp., Diplodia spp., and the others; Viral diseases of various plants mediated by Polymyxa spp., Olpidium spp., or the others; and rice bacterial seedling blight (Burkholderia plantarii); cucumber angular leaf spot (Pseudomonas syringae pv. Lachrymans); eggplant bacterial wilt (Ralstonia solanacearum); citrus canker (Xanthomonas citri); Chinese cabbage bacterial soft rot (Erwinia carotovora); and the others. Examples of the harmful arthropods include the followings. Hemiptera pests: Delphacidae (for example, Laodelphax striatellus, Nilaparvata lugens, Sogatella furcifera, Peregrinus maidis, Javesella pellucida, Perkinsiella saccharicida, or Tagosodes orizicolus); Cicadellidae (for example, Nephotettix cincticeps, Nephotettix virescens, Nephotettix nigropictus, Recilia dorsalis, Empoasca onukii, Empoasca fabae, Dalbulus maidis, or Cofana spectra); Cercopidae (for example, Mahanarva posticata or Mahanarva fimbriolata); Aphididae (for example, Aphis fabae, Aphis glycines, Aphis gossypii, Aphis pomi, Aphis spiraecola, Myzus persicae, Brachycaudus helichrysi, Brevicoryne brassicae, Dysaphis plantaginea (Rosy apple aphid), Lipaphis erysimi, Macrosiphum euphorbiae, Aulacorthum solani, Nasonovia ribisnigri, Rhopalosiphum padi, Rhopalosiphum maidis, Toxoptera citricidus, Hyalopterus pruni, Melanaphis sacchari, Tetraneura nigri- abdominalis, Ceratovacuna lanigera, or Eriosoma lanigerum); Phylloxeridae (for example, Daktulosphaira vitifoliae, Phylloxera devastatrix (Pecan phylloxera), Phylloxera notabilis (Pecan leaf phylloxera), or Phylloxera russellae (Southern pecan leaf phylloxera)); Adelgidae (for example, Adelges tsugae, Adelges piceae, or Aphrastasia pectinatae); Pentatomidae (for example, Scotinophara lurida, Scotinophara coarctata (Malayan rice black bug), Nezara antennata, Eysarcoris aeneus, Eysarcoris lewisi, Eysarcoris ventralis, Eysarcoris annamita, Halyomorpha halys, Nezara viridula, Euschistus heros (Brown stink bug), Piezodorus guildinii (Red banded stink bug), Oebalus pugnax, or Dichelops melacanthus); Cydnidae (for example, Scaptocoris castanea (Burrower brown bug)); Alydidae (for example, Riptortus pedestris, Leptocorisa chinensis, or Leptocorisa acuta); Coreidae (for example, Cletus punctiger or Leptoglossus australis); Lygaeidae (for example, Caverelius saccharivorus, Togo hemipterus, or Blissus leu- copterus); Miridae (for example, Trigonotylus caelestialium, Stenotus rubrovittatus, Stenodema calcarata, or Lygus lineolaris); Aleyrodidae (for example, Trialeurodes vaporariorum, Bemisia tabaci, Dialeurodes citri, Aleurocanthus spiniferus, Aleurocanthus camelliae, or Pealius euryae); Diaspididae (for example, Abgrallaspis cyanophylli, Aonidiella aurantii, Diaspidiotus perniciosus, Pseudaulacaspis pentagona, Unaspis yanonensis, or Unaspis citri); Coccidae (for example, Ceroplastes rubens); Margarodidae (for example, leerya purchasi or leerya seychellarum); Pseudococcidae (for example, Phenacoccus solani, Phenacoccus solenopsis, Planococcus kraunhiae, Pseudococcus comstocki, Planococcus citri, Pseudococcus cal- ceolariae, Pseudococcus longispinus, or Brevennia rehi); Psyllidae (for example, Diaphorina citri, Trioza erytreae, Cacopsylla pyrisuga, Ca- copsylla chinensis, Bactericera cockerelli, or Cacopsylla pyricola (Pear psylla)); Tingidae (for example, Corythucha ciliata, Corythucha marmorata, Stephanitis nashi, or Stephanitis pyrioides); Cimicidae (for example, Cimex lectularius); Cicadidae (for example, Quesada gigas (Giant Cicada)); and the others. Lepidoptera pests: Crambidae (for example, Chilo suppressalis, Chilo polychrysus (Darkheaded stem borer), Scirpophaga innotata (White stem borer), Scirpophaga incertulas, Rupela albina, Cnaphalocrocis medinalis, Marasmia patnalis, Marasmia exigua, Notarcha derogata, Ostrinia furnacalis, Ostrinia nubilalis (European corn borer), Hellula undalis, Herpetogramma luctuosale, Pediasia teterrellus, Nymphula depunctalis, or Diatraea saccharalis (Sugarcane borer)); Pyralidae (for example, Elasmopalpus lignosellus or Plodia interpunctella); Noctuidae (for example, Spodoptera litura, Spodoptera exigua, Mythimna separata, Mamestra brassicae, Sesamia inferens, Spodoptera mauritia, Naranga aenescens, Spodoptera frugiperda, Spodoptera exempta, Agrotis ipsilon, Autographa nigrisigna, Plusia festucae, Chrysodeixis includens (Soybean looper), Trichoplusia spp., Heliothis spp. (for example, Heliothis virescens), Helicoverpa armigera, Helicoverpa spp. (for example, Helicoverpa zea), Anticarsia gemmatalis (Velvetbean caterpillar), Alabama argillacea (Cotton leafworm), or Hydraecia immanis (Hop vine borer)); Pieridae (for example, Pieris rapae); Tortricidae (for example, Grapholita molesta, Grapholita dimorpha, Leguminivora glycinivorella, Matsumuraeses azukivora, Adoxophyes orana fasciata, Adoxophyes honmai, Homona magnanima, Archips fuscocupreanus, Cydia pomonella, Tetramoera schistaceana, Epinotia aporema (Bean Shoot Borer), or Ecdytolopha aurantiana (Citrus fruit borer)); Gracillariidae (for example, Caloptilia theivora or Phyllonorycter ringoniella); Carposinidae (for example, Carposina sasakii); Lyonetiidae (for example, Leucoptera coffeella (Coffee Leaf miner), Lyonetia clerkella, or Lyonetia prunifoliella); Lymantriidae (for example, Lymantria spp. (for example, Lymantria dispar) or Euproctis spp. (for example, Euproctis pseudoconspersa)); Pluteliidae (for example, Plutella xylostella); Gelechiidae (for example, Anarsia lineatella, Helcystogramma triannulellum, Pectinophora gossypiella, Phthorimaea operculella, or Tuta absoluta); Arctiidae (for example, Hyphantria cunea); Castniidae (for example, Telchin licus (Giant Sugarcane borer)); Cossidae (for example, Cossus insularis); Geometridae (for example, Ascotis selenaria); Limacodidae (for example, Parasa lepida); Stathmopodidae (for example, Stathmopoda masinissa); Sphingidae (for example, Acherontia lachesis); Sesiidae (for example, Nokona feralis); Hesperiidae (for example, Parnara guttata); and the others. Thysanoptera pests: Thripidae (for example, Frankliniella occidentalis, Thrips palmi, Scirtothrips dorsalis, Thrips tabaci, Frankliniella intonsa, Stenchaetothrips biformis, or Echinothrips americanus); Phlaeothripidae (for example, Haplothrips aculeatus); and the others. [0071] Diptera pests: Anthomyiidae (for example, Delia platura or Delia antiqua); Ulidiidae (for example, Tetanops myopaeformis); Agromyzidae (for example, Agromyza oryzae, Liriomyza sativae, Liriomyza trifolii, or Chromatomyia hordeola); Chloropidae (for example, Chlorops oryzae); Tephritidae (for example, Bactrocera cucurbitae, Bactrocera dorsalis, Bactrocera latifrons, Bactrocera oleae, Bactrocera tryoni, or Ceratitis capitata); Ephydridae (for example, Hydrellia griseola, Hydrellia philippina, or Hydrellia sasakii); Drosophilidae (for example, Drosophila suzukii); Phoridae (for example, Megaselia spiracularis); Psychodidae (for example, Clogmia albipunctata); Sciaridae (for example, Bradysia difformis); Cecidomyiidae (for example, Mayetiola destructor or Orseolia oryzae); Diopsidae (for example, Diopsis macrophthalma); Tipulidae (for example, Tipula aino, Tipula oleracea (Common cranefly), or Tipula paludosa (European cranefly)); and the others. [0072] Coleoptera pests: Chrysomelidae (for example, Diabrotica virgifera virgifera, Diabrotica undecim- punctata howardi, Diabrotica barberi, Diabrotica virgifera zeae, Diabrotica balteata, Diabrotica speciosa (Cucurbit Beetle), Cerotoma trifurcata, Oulema melanopus, Aulacophora femoralis, Phyllotreta striolata, Leptinotarsa decemlineata, Oulema oryzae, Colaspis brunnea, Chaetocnema pulicaria, Chaetocnema confnis, Epitrix cucumeris, Dicladispa armigera, Colaspis brunnea (Grape Colaspis), Myochrous den- ticollis (southern corn leaf beetle), Laccoptera quadrimaculata, or Epitrix hirtipennis); Carabidae (for example, Stenolophus lecontei (Seedcorn beetle) or Clivina im- pressifrons (Slender seedcorn beetle)); Scarabaeidae (for example, Anomala cuprea, Anomala rufocuprea, Anomala al- bopilosa, Popillia japonica, Heptophylla picea, Rhizotrogus majalis (European Chafer), Tomarus gibbosus, Holotrichia spp., or Phyllophaga spp. (for example, Phyllophaga crinita)); Curculionidae (for example, Araecerus coffeae, Cylas formicarius, Euscepes post- fasciatus, Hypera postica, Sitophilus zeamais, Echinocnemus squameus, Lissorhoptrus oryzophilus, Rhabdoscelus lineatocollis, Anthonomus grandis, Sphenophorus venatus, Sphenophorus callosus (Southern Corn Billbug), Sternechus subsignatus (Soybean stalk weevil), Sphenophorus levis (Sugarcane weevil), Scepticus griseus, Scepticus uniformis, Zabrotes subfasciatus, Tomicus piniperda, or Hypothenemus hampei (Coffee Berry Borer)); Tenebrionidae (for example, Tribolium castaneum or Tribolium confusum); Coccinellidae (for example, Epilachna vigintioctopunctata); Bostrychidae (for example, Lyctus brunneus); Ptinidae; Cerambycidae (for example, Anoplophora malasiaca or Migdolus fryanus); Elateridae (Agriotes sp., Aelous sp., Anchastus sp., Melanotus sp., Limonius sp., Conoderus sp., Ctenicera sp.) (for example, Melanotus okinawensis, Agriotes fus- cicollis, Melanotus legatus, Anchastus spp., Conoderus spp., Ctenicera spp., Limonius spp., or Aeolus spp.); Staphylinidae (for example, Paederus fuscipes); and the others. [0073] Orthoptera pests: Acrididae (for example, Locusta migratoria, Dociostaurus maroccanus, Chortoicetes terminifera, Nomadacris septemfasciata, Locustana pardalina (Brown Locust), Anacridium melanorhodon (Tree Locust), Calliptamus italicus (Italian Locust), Melanoplus differentialis (Differential grasshopper), Melanoplus bivittatus (Two striped grasshopper), Melanoplus sanguinipes (Migratory grasshopper), Melanoplus fe- murrubrum (Red-Legged grasshopper), Camnula pellucida (Clearwinged grasshopper), Schistocerca gregaria, Gastrimargus musicus (Yellow-winged locust), Austracris guttulosa (Spur-throated locust), Oxya yezoensis, Oxya japonica, or Patanga succincta); Gryllotalpidae (for example, Gryllotalpaorientalis); Gryllidae (for example, Acheta domesticus or Teleogryllus emma); Tettigoniidae (for example, Anabrus simplex (Mormon cricket)); and the others. Hymenoptera pests: Tenthredinidae (for example, Athalia rosae or Athalia japonica); Solenopsis spp.; Formicidae (for example, Atta capiguara (Brown leaf-cutting ant)); and the others. [0074] Blattodea pests: Blattellidae (for example, Blattella germanica); Blattidae (for example, Periplaneta fuliginosa, Periplaneta americana, Periplaneta brunnea, or Blatta orientalis); Termitidae (for example, Reticulitermes speratus, Coptotermes formosanus, In- cisitermes minor, Cryptotermes domesticus, Odontotermes formosanus, Neotermes koshunensis, Glyptotermes satsumensis, Glyptotermes nakajimai, Glyptotermes fuscus, Hodotermopsis sjostedti, Coptotermes guangzhouensis, Reticulitermes amamianus, Reticulitermes miyatakei, Reticulitermes kanmonensis, Nasutitermes takasagoensis, Pericapritermes nitobei, Sinocapritermes mushae, or Cornitermes cumulans); and the others. Examples [0075] The following Examples including Preparation examples, Reference preparation examples, Formulation examples, and Test examples, serve to illustrate the present invention in more detail, which should not intend to limit the present invention. [0076] Preparation example 1-1 To a mixture of the intermediate compound (Alal) 1.7 g described in the Reference preparation example 1, N,N-dimethylformamide 20 mL, and pyridine 1.4 niL was added trifluoroacetic anhydride 1.4 mL at room temperature, and then the resulting mixtures were heated at 80°C with stirring for 6 hours. Then, to the resulting mixtures was added water 20 mL at room temperature, and the mixtures were extracted with ethyl acetate, and the organic layers were washed with 2N hydrochloric acid, and then the organic layers were dried and concentrated under reduced pressure. The resulting residues were subjected to a silica gel column chromatography (hexane:ethyl acetate=4:l) to give the Present compound 1 represented by the following formula 1.8

g - hem.25]

δ Present compound 1: Ή -NMR (CDC13) : 8.09-8.06 (2H, m), 7.48-7.46 (2H, m), 3.73 (2H, s), 2.01 (3H, s). Preparation example 1-2 The compound of the present invention prepared according to the process described in the Preparation example 1-1 and the physical properties thereof are shown below. A compound represented by formula (la): [Chem.26]

wherein R8, R , and R 10 represent any one combination indicated in the [Table 1]. [Table 1]

δ Present compound 19: Ή -NMR (CDC13) : 8.08-8.06 (2H, m), 7.49-7.47 (2H, m), 3.78 (2H, s), 2.48-2.43 (2H, m), 1.27-1.22 (3H, m). δ Present compound 33: Ή -NMR (CDC13) : 8.07-8.05 (2H, m), 7.50-7.49 (2H, m), 3.80 (2H, s), 2.83-2.78 (1H, m), 1.27 (6H, d). δ Present compound 34: Ή -NMR (CDC13) : 8.13-8.10 (2H, m), 7.53-7.51 (2H, m), 4.18 (2H, s). [0078] A compound represented by formula (lb): [Chem.27]

wherein R8, R , and R 10 represent the combination indicated in the [Table 2]. [Table 2]

δ Present compound 2: Ή -NMR (CDC13) : 8.06-8.05 (1H, m), 8.02-8.00 (1H, m), 7.55-7.53 (1H, m), 7.50-7.48 (1H, m), 3.75 (2H, s), 2.02 (3H, s). [0079] A compound represented by formula (lc): [Chem.28]

wherein R8, R , R 10, R2 1, and R22 represent any one combination indicated in the [Table 3]. [Table 3]

δ Present compound 3: Ή -NMR (CDC13) : 8.20-8.17 (2H, m), 7.61-7.60 (2H, m), 4.34 (2H, s), 2.84 (3H, s). δ Present compound 21: Ή -NMR (CDC13) : 8.03-8.01 (1H, m), 7.95-7.93 (1H, m), 7.71-7.68 (1H, m), 4.40 (2H, s), 2.89 (3H, s). δ Present compound 22: Ή -NMR (CDC13) : 8.18-8.14 (1H, m), 7.42-7.39 (2H, m), 4.33 (2H, s), 2.88 (3H, s). [0080] A compound represented by formula (Id): [Chem.29

wherein R8, R , and R 10 represent the combination indicated in the [Table 4]. [Table 4]

δ Present compound 4: Ή -NMR (CDC13) : 8.19 (1H, dt), 8.16-8.16 (1H, m), 7.68 (1H, dt), 7.63-7.60 (1H, m), 4.35 (2H, s), 2.85 (3H, s). [0081] A compound represented by formula (le): [Chem.30]

wherein R6, R8, R , and R 10 represent any one combination indicated in the [Table 5]. [Table 5]

δ Present compound 5: Ή -NMR (CDC13) : 8.13 (2H, d), 7.53 (2H, d), 4.72 (1H, s), 4.43 (2H, d), 2.94 (3H, s). δ Present compound 23: Ή -NMR (CDC13) : 8.14-8.12 (2H, m), 7.54-7.52 (2H, m), 4.64 (1H), 4.40 (2H, d), 3.02 (2H, q), 1.37 (3H, t). δ Present compound 24: Ή -NMR (CDC13) : 8.14-8.11 (2H, m), 7.54-7.52 (2H, m), 4.42 (3H, s), 3.14 (1H, t), 1.40 (6H, d). δ Present compound 25: Ή -NMR (CDC13) : 8.13-8.11 (2H, m), 7.56-7.53 (2H, m), 4.72 (1H, t), 4.44 (2H, d), 2.42-2.35 (1H, m), 1.20-1.16 (2H, m), 0.99-0.94 (2H, m). δ Present compound 35: Ή -NMR (CDC13) : 8.14-8.11 (2H, m), 7.53-7.51 (2H, m), 4.46 (1H, br s), 4.40 (2H, d), 2.99-2.95 (2H, m), 1.88-1.82 (2H, m), 1.03 (3H, t). δ Present compound 36: Ή -NMR (CDC13) : 8.13-8.11 (2H, m), 7.52 (2H, d), 4.69 (1H, t), 4.40 (2H, d), 3.00-2.96 (2H, m), 1.82-1.74 (2H, m), 1.47-1.37 (2H, m), 0.92 (3H, t). δ Present compound 37: Ή -NMR (CDC13) : 8.12 (2H, d), 7.52 (2H, d), 4.72 (1H, t), 4.39 (2H, d), 2.90-2.88 (2H, m), 2.30-2.20 (1H, m), 1.08 (6H, d). Present compound 38: Ή -NMR (DMSO-D ) δ : 8.06-8.04 (2H, m), 7.80 (1H, s), 7.56-7.54 (2H, m), 7.39-7.37 (5H, m), 4.38 (2H, s), 4.20 (2H, s). δ Present compound 39: Ή -NMR (CDC13) : 8.13-8.10 (2H, m), 7.58-7.56 (2H, m), 4.51 (2H, s), 2.86 (3H, s), 2.42-2.37 (1H, m), 0.87-0.82 (2H, m), 0.81-0.76 (2H, m). δ Present compound 40: Ή -NMR (CDC13) : 8.03-8.01 (2H, m), 7.44 (2H, d), 7.36-7.32 (2H, m), 7.30-7.26 (3H, m), 4.93 (2H, s), 2.99 (3H, s). δ Present compound 41: Ή -NMR (CDC13) : 8.04-8.01 (2H, m), 7.40-7.37 (2H, m), 7.24-7.15 (4H, m), 4.85 (1H, br s), 4.72 (1H, br s), 3.00 (3H, s), 2.14 (3H, s). δ Present compound 42: Ή -NMR (CDC13) : 8.04-8.01 (2H, m), 7.44 (2H, d), 7.23-7.19 (1H, m), 7.10-7.06 (3H, m), 4.91 (2H, s), 2.98 (3H, s), 2.31 (3H, s). δ Present compound 43: Ή -NMR (CDC13) : 8.04-8.01 (2H, m), 7.44 (2H, d), 7.16-7.11 (4H, m), 4.90 (2H, s), 2.97 (3H, s), 2.30 (3H, s). δ Present compound 44: Ή -NMR (CDC13) : 8.03-8.01 (2H, m), 7.45 (2H, d), 7.32-7.28 (1H, m), 7.20-7.11 (2H, m), 7.07-7.02 (1H, m), 4.88 (2H, s), 3.06 (3H, s). δ Present compound 45: Ή -NMR (CDC13) : 8.02-8.00 (2H, m), 7.44 (2H, d), 7.29-7.25 (1H, m), 7.10-7.08 (1H, m), 6.95-6.93 (1H, m), 6.85-6.80 (1H, m), 4.85 (2H, br s), 3.93 (3H, s), 3.02 (3H, s). δ Present compound 46: Ή -NMR (CDC13) : 8.09 (2H, d), 7.57 (2H, d), 4.61 (2H, s), 3.02 (3H, s), 1.46 (9H, s) δ Present compound 90: Ή -NMR (CDC13) : 8.10 (2H, d), 7.56 (2H, d), 4.44 (2H, s), 4.26-4.35 (1H, m), 2.91 (3H, s), 1.84-1.91 (2H, m), 1.43-1.75 (6H, m) δ Present compound 91: Ή -NMR (CDC13) : 8.09 (2H, d), 7.57 (2H, d), 4.46 (2H, s), 3.69-3.77 (1H, m), 2.88 (3H, s), 1.71-1.81 (4H, m), 1.55-1.63 (1H, m), 1.25-1.41 (4H, m), 0.95-1.05 (lH, m) δ Present compound 92: Ή -NMR (CDC13) : 8.14-8.11 (2H, m), 7.56-7.54 (2H, m), 4.51 (2H, s), 3.43-3.39 (2H, m), 2.98 (3H, s), 2.60-2.56 (2H, m), 2.06 (3H, s). A compound represented by formula (If): [Chem.31]

wherein R6, R8, R , and R 10 represent any one combination indicated in the [Table 6]. [Table 6]

δ Present compound 6: Ή -NMR (CDC13) : 8.10-8.07 (2H, m), 7.61-7.60 (1H, m), 7.57-7.53 (1H, m), 4.78 (1H, s), 4.43 (2H, d), 2.95 (3H, s). δ Present compound 26: Ή -NMR (CDC13) : 8.10-8.06 (2H, m), 7.62-7.60 (1H, m), 7.57-7.53 (1H, m), 4.64 (1H, br s), 4.41 (2H, d), 3.02 (2H, q), 1.37 (3H, t). δ Present compound 27: Ή -NMR (CDC13) : 8.09-8.06 (2H, m), 7.62-7.60 (IH, m), 7.56-7.52 (IH, m), 4.50 (IH, br s), 4.42 (2H, d), 3.18-3.12 (IH, m), 1.39 (6H, d). δ Present compound 28: Ή -NMR (CDC13) : 8.13-8.12 (IH, m), 8.08-8.06 (IH, m), 7.63-7.60 (IH, m), 7.56-7.52 (IH, m), 4.74 (IH, t), 4.45 (2H, d), 2.43-2.37 (IH, m), 1.21-1.16 (2H, m), 1.00-0.95 (2H, m). [0083] A compound represented by formula (lg): [Chem.32]

wherein R 1 1 and R 12 represent any one combination indicated in the [Table 7]. [Table 7]

δ Present compound 7: Ή -NMR (CDC13) : 8.17-8.15 (2H, m), 7.59-7.58 (2H, m), 4.34 (2H, s), 4.08 (IH, d), 2.75 (3H, d). δ Present compound 8: -NMR (CDC13) : 8.16-8.14 (2H, m), 7.59-7.57 (2H, m), 4.32 (2H, s), 4.06 (IH, t), 3.12-3.05 (2H, m), 1.16 (3H, t). δ Present compound 9: -NMR (CDC13) : 8.17-8.14 (2H, m), 7.59-7.56 (2H, m), 4.33 (2H, s), 4.11 (IH, t), 3.00 (2H, td), 1.58-1.49 (2H, m), 0.91 (3H, t). δ Present compound 10: -NMR (CDC13) : 8.17-8.14 (2H, m), 7.60-7.57 (2H, m), 4.34 (2H, s), 4.25 (IH, t), 2.89 (2H, dd), 1.02-0.94 (IH, m), 0.58-0.52 (2H, m), 0.21-0.17 (2H, m). δ Present compound 11: Ή -NMR (CDC13) : 8.17-8.14 (2H, m), 7.60-7.57 (2H, m), 4.29 (2H, s), 2.79 (6H, s). δ Present compound 12: Ή -NMR (CDC13) : 8.16-8.13 (2H, m), 7.59-7.57 (2H, m), 4.32 (2H, s), 3.23-3.20 (4H, m), 1.87-1.84 (4H, m). [0084] [Chem.33]

δ Present compound 47: Ή -NMR (CDC13) : 8.08-8.06 (2H, m), 7.09-7.06 (2H, m), 5.22 (2H, s), 2.28 (3H, s). [0085] [Chem.34]

δ Present compound 50: Ή -NMR (CDC13) : 8.83 (1H, d), 8.27-8.25 (1H, m), 8.08 (1H, dd), 4.37 (2H, s), 2.91 (3H, s). [0086] [Chem.35]

δ Present compound 51: Ή -NMR (CDC13) : 8.13-8.10 (2H, m), 7.54-7.52 (2H, m), 4.26 (2H, s), 3.26-3.22 (2H, m), 3.16 (2H, t), 2.40-2.33 (2H, m). [0087] [Chem.36]

Present compound 52: Ή -NMR (CDCl,) δ : 8.12-8.09 (2H, m), 7.53-7.51 (2H, m), 4.39 (2H, s), 3.28-3.25 (2H, m), 3.15-3.12 (2H, m), 2.28-2.22 (2H, m), 1.70-1.64 (2H, m). [Chem.37]

δ Present compound 53: Ή -NMR (CDC13) : 8.06-8.03 (2H, m), 7.91-7.87 (2H, m), 7.39-7.37 (2H, m), 7.22-7.17 (2H, m), 4.84 (1H, t), 4.25 (2H, d). [0089] [Chem.38]

δ Present compound 54: Ή -NMR (CDC13) : 7.98 (IH, dd), 7.89 (IH, dd), 7.71 (IH, t), 4.36 (2H, s), 2.80 (6H, s). [0090] [Chem.39]

Present compound 55: Ή -NMR (DMSO-D ) δ: 8.07-8.05 (2H, m), 7.84 (IH, t), 7.60-7.58 (2H, m), 4.23 (2H, d), 2.65 (6H, s). [009 1] Preparation example 2-1 To a mixture of the Present compound 1 (2.4 g) described in the Preparation example 1-1 and chloroform 70 mL was added m-chloroperbenzoic acid 2.2 g at 0°C. The resulting mixtures were stirred at room temperature for 4 hours, and then to the mixtures was added water 70 mL, and the mixtures were extracted with chloroform, and the organic layers were washed with a saturated aqueous solution of sodium hydrogen sulfite. The organic layers were dried and concentrated under reduced pressure, and the resulting residues were subjected to a silica gel column chro matography (hexane:ethyl acetate=l:2) to give the Present compound 13 represented by the following formula 1.7 g. [Chem.40]

δ Present compound 13: Ή -NMR (CDC13) : 8.16-8.15 (2H, m), 7.49-7.47 (2H, m), 4.04 (2H, s), 2.51 (3H, s). [0092] Preparation example 3-1 To a mixture of the Present compound 1 (1.9 g) described in the Preparation example 1-1, cyanamide 0.4 g, and acetonitrile 20 mL was added iodobenzene diacetate 2.4 g at room temperature. The resulting mixtures were stirred at room temperature for 7 hours, and then concentrated under reduced pressure. The resulting residues were subjected to a silica gel column chromatography (hexane:ethyl acetate=l:2) to give the Present compound 14 represented by the following formula 1.5 g. [Chem.41]

δ Present compound 14: Ή -NMR (CDC13) : 8.21-8.20 (2H, m), 7.57-7.55 (2H, m), 4.48 (1H, d), 4.25 (1H, d), 2.82 (3H, s). Preparation example 3-2 The compound of the present invention prepared according to the process described in the Preparation example 3-1 and the physical properties thereof are shown below. A compound represented by formula (li): [Chem.42]

wherein R8, R , and R 10 represent any one combination indicated in the [Table 8]. [Table 8]

δ Present compound 29: Ή -NMR (CDC13) : 8.21-8.19 (2H, m), 7.57-7.55 (2H, m), 4.43 (1H, d), 4.21 (1H, d), 3.22-3.18 (1H, m), 2.97-2.92 (1H, m), 1.49 (3H, t). δ Present compound 56: Ή -NMR (CDC13) : 8.20-8.18 (2H, m), 7.60-7.58 (2H, m), 4.33 (1H, d), 4.19 (1H, d), 3.37-3.30 (1H, m), 1.55 (3H, d), 1.50 (3H, d). A compound represented by formula (lj): [Chem.43

wherein R8, R , and R 10 represent the combination indicated in the [Table 9]. [Table 9]

δ Present compound 15: Ή -NMR (CDC13) : 8.22-8.19 (1H, m), 8.13 (1H, br s), 7.65-7.63 (2H, m), 4.48 (1H, d), 4.29 (1H, d), 2.84 (3H, s). Preparation example 4-1 To a mixture of the Present compound 14 (1.3 g) described in the Preparation example 3-1, ruthenium(III) chloride hydrate 0.09 g, acetonitrile 7 mL, chloroform 7 mL, and water 7 mL was added sodium periodate 2.7 g at room temperature. The resulting mixtures were stirred at room temperature for 2 hours, and then to the mixtures was added water 20 mL. The resulting mixtures were filtered, and the filtrate was extracted with ethyl acetate, and the organic layers were washed with a saturated aqueous solution of sodium hydrogen sulfite and saturated brine, and the organic layers were dried and concentrated under reduced pressure. The resulting residues were subjected to a silica gel column chromatography (hexane:ethyl acetate=l:2) to give the Present compound 16 represented by the following formula 0.8 g. [Chem.44]

δ Present compound 16: Ή -NMR (CDC13) : 8.26-8.23 (2H, m), 7.66-7.63 (2H, m), 4.71 (2H, dd), 3.10 (3H, s). Preparation example 4-2 The compound of the present invention prepared according to the process described in the Preparation example 4-1 and the physical properties thereof are shown below. A compound represented by formula (lk): [Chem.45]

i i I CN wherein R8, R , and R 10 represent any one combination indicated in the [Table 10]. [Table 10]

δ Present compound 30: Ή -NMR (CDC13) : 8.25-8.22 (2H, m), 7.65-7.63 (2H, m), 4.70-4.62 (2H, m), 3.25-3.14 (2H, m), 1.50 (3H, t). δ Present compound 57: Ή -NMR (CDC13) : 8.24-8.21 (2H, m), 7.65-7.63 (2H, m), 4.68-4.59 (2H, m), 3.38-3.31 (1H, m), 1.54 (3H, d), 1.52 (3H, d). A compound represented by formula (11): [Chem.46

wherein R8, R , and R 10 represent the combination indicated in the [Table 11]. [Table 11]

δ Present compound 17: Ή -NMR (CDC13) : 8.27 (1H, dt), 8.19 (1H, t), 7.73-7.71 (1H, m), 7.72-7.69 (1H, m), 4.70 (2H, dd), 3.12 (3H, s). Preparation example 5-1 To a mixture of the Present compound 13 (0.5 g) described in the Preparation example 2-1, ammonium carbamate 0.5 g, and iodobenzene diacetate 1.7 g was added methanol 4 mL at room temperature. The resulting mixtures were stirred at room tem perature for 5 hours, and then the resulting mixtures were concentrated under reduced pressure, and the resulting residues were subjected to a silica gel column chro matography (hexane:ethyl acetate=l:2) to give the Present compound 18 represented by the following formula 0.3 g. Chem.47

δ Present compound 18: Ή -NMR (CDC13) : 8.20-8.17 (2H, m), 7.61-7.58 (2H, m), 4.46 (1H, d), 4.32 (1H, d), 2.98 (3H, s), 2.67 (1H, br s). [0099] Preparation example 6-1 To a mixture of the Present compound 19 (0.5 g) described in the Preparation example 1-2, acetonitrile 0.4 niL, chloroform 0.4 mL, and water 0.4 mL was added ruthenium(III) chloride hydrate 0.04 g at room temperature, and then to the resulting mixtures was added sodium periodate 1.1 g. The resulting mixtures were stirred at room temperature for 5 hours and then filtered, and the filtrate was extracted with ethyl acetate, and the organic layers were washed with a saturated aqueous solution of sodium hydrogen sulfite and saturated brine, and the organic layers were dried and concentrated under reduced pressure. The resulting residues were subjected to a silica gel column chromatography (hexane:ethyl acetate=l:l) to give the Present compound 20 represented by the following formula 0.35 g. [Chem.48]

δ Present compound 20: Ή -NMR (CDC13) : 8.19-8.16 (2H, m), 7.61-7.58 (2H, m), 4.30 (2H, s), 2.93 (2H, q), 1.40 (3H, t). [0100] Preparation example 6-2 The compound of the present invention prepared according to the process described in the Preparation example 6-1 and the physical properties thereof are shown below. A compound represented by formula (lc): [Chem.49]

R 2 1 R 22 wherein R8, R , R 10 , R2 1, and R22 represent any one combination indicated in the [Table 12]. [Table 12]

δ Present compound 58: Ή -NMR (CDC13) : 8.18-8.15 (2H, m), 7.62-7.59 (2H, m), 4.29 (2H, s), 3.09-3.02 (1H, m), 1.42 (6H, d). δ Present compound 59: Ή -NMR (CDC13) : 8.23-8.20 (2H, m), 7.62-7.60 (2H, m), 4.56 (2H, s). A compound represented by formula (lm): [Chem.50]

wherein m is any one integer indicated in the [Table 13]. [Table 13]

δ Present compound 60: Ή -NMR (CDC13) : 8.14-8.10 (2H, m), 7.21-7.18 (2H, m), 5.05 (2H, s), 3.06 (3H, s). δ Present compound 61: Ή -NMR (CDC13) : 8.10-8.08 (2H, m), 7.05-7.03 (2H, m), 4.53 (2H, t), 3.50 (2H, t), 3.09 (3H, s). δ Present compound 62: Ή -NMR (CDC13) : 8.08-8.05 (2H, m), 7.03-7.00 (2H, m), 4.21 (2H, t), 3.28 (2H, t), 2.98 (3H, s), 2.44-2.37 (2H, m). Preparation example 7-1 To a mixture of 4-[5-(trifluoromethyl)-l,2,4-oxadiazol-3-yl]phenol 1.0 g, 2-(methylthio)ethanol 0.8 g, and tetrahydrofuran 30 mL were added successively triph- enylphosphine 2.0 g and bis(2-methoxyethyl)diazene-l,2-dicarboxylate 2.0 g at 0°C, and then the mixtures were warmed to 45°C and stirred for 3 hours. The reaction mixtures were cooled to room temperature and concentrated under reduced pressure, and then to the mixtures was added water 20 mL. The mixtures were extracted with ethyl acetate, the organic layers were washed with saturated brine, and the organic layers were dried and concentrated under reduced pressure. The resulting residues were subjected to a silica gel column chromatography (hexane:ethyl acetate=4:l) to give the Present compound 48 represented by the following formula 0.69 g. [Chem.51

δ Present compound 48: Ή -NMR (CDC13) : 8.07-8.04 (2H, m), 7.03-7.01 (2H, m), 4.24 (2H, t), 2.92 (2H, t), 2.24 (3H, s). Preparation example 7-2 The Present compound 49 was prepared according to the process described in the Preparation example 7-1. [Chem.52]

δ Present compound 49: Ή -NMR (CDC13) : 8.06-8.03 (2H, m), 7.03-7.00 (2H, m), 4.15 (2H, t), 2.71 (2H, t), 2.15-2.08 (5H, m). Preparation example 8-1 To a mixture of the Present compound 5 (0.4 g) described in the Preparation example 1-2 and N,N-dimethylformamide 20 mL was added sodium hydride (60%, oily) 0.06 g at 0°C, and then the resulting mixtures were stirred at room temperature for 10 minutes. To the resulting mixtures was added methyl iodide 0.3 g at 0°C, and then the resulting mixtures were stirred at room temperature for 5 hours. To the resulting mixtures was added water 50 mL, and the mixtures were extracted with ethyl acetate. The organic layers were washed with saturated brine, dried, and concentrated under reduced pressure, and the resulting residues were subjected to a silica gel column chro matography (hexane:ethyl acetate=l:l) to give the Present compound 3 1 represented by the following formula 0.3 g. [Chem.53]

δ Present compound 31: Ή -NMR (CDC13) : 8.14-8.12 (2H, m), 7.54-7.52 (2H, m), 4.40 (2H, s), 2.90 (3H, s), 2.82 (3H, s). [0105] Preparation example 8-2 The compound of the present invention prepared according to the process described in the Preparation example 8-1 and the physical properties thereof are shown below. [0106] A compound represented by formula (le): [Chem.54]

wherein R6, R8, R , and R 10 represent any one combination indicated in the [Table 14]. [Table 14]

δ Present compound 63: Ή -NMR (CDC13) : 8.13-8.10 (2H, m), 7.56-7.53 (2H, m), 4.47 (2H, s), 3.31 (2H, q), 2.91 (3H, s), 1.15 (3H, t). δ Present compound 64: Ή -NMR (CDC13) : 8.11-8.08 (2H, m), 7.60-7.57 (2H, m), 4.44 (2H, s), 4.22-4.16 (1H, m), 2.88 (3H, s), 1.19 (6H, d). δ Present compound 65: Ή -NMR (CDC13) : 8.13-8.10 (2H, m), 7.56-7.54 (2H, m), 4.46 (2H, s), 3.01 (2H, d), 2.86 (3H, s), 1.84-1.74 (1H, m), 0.87 (6H, d). δ Present compound 66: -NMR (CDC13) : 8.14-8.12 (2H, m), 7.58-7.56 (2H, m), 4.53 (2H, s), 3.96 (2H, d), 3.05 (3H, s), 2.45 (1H, t). δ Present compound 67: -NMR (CDC13) : 8.14 (2H, d), 7.54 (2H, d), 6.06-5.78 (1H, m), 4.62 (2H, s), 3.57 (2H, td), 3.01 (3H, s). δ Present compound 68: -NMR (CDC13) : 8.12-8.10 (2H, m), 7.56 (2H, d), 4.58 (2H, s), 3.12 (2H, d), 2.98 (3H, s), 0.94-0.88 (1H, m), 0.54-0.49 (2H, m), 0.20-0.16 (2H, m). δ Present compound 69: Ή -NMR (CDC13) : 8.18-8.16 (2H, m), 7.58-7.56 (2H, m), 4.55 (2H, s), 4.09 (2H, s), 3.11 (3H, s). δ Present compound 70: Ή -NMR (CDC13) : 8.10-8.08 (2H, m), 7.47-7.45 (2H, m), 7.36-7.32 (3H, m), 7.30-7.28 (2H, m), 4.43 (2H, s), 4.38 (2H, s), 2.85 (3H, s). δ Present compound 71: Ή -NMR (CDC13) : 8.13-8.11 (2H, m), 7.55 (2H, d), 4.57 (2H, s), 4.56 (2H, s), 3.47 (2H, q), 3.01 (3H, s), 1.20 (3H, t). δ Present compound 72: Ή -NMR (CDC13) : 8.14-8.11 (2H, m), 7.54-7.52 (2H, m), 4.45 (2H, s), 3.09 (2H, q), 2.83 (3H, s), 1.42 (3H, t). δ Present compound 73: Ή -NMR (CDC13) : 8.13-8.10 (2H, m), 7.55-7.53 (2H, m), 4.51 (2H, s), 3.31 (2H, q), 3.05 (2H, q), 1.40 (3H, t), 1.13 (3H, t). δ Present compound 74: Ή -NMR (CDC13) : 8.11-8.07 (2H, m), 7.60-7.57 (2H, m), 4.46 (2H, s), 4.18-4.11 (1H, m), 2.93 (2H, q), 1.35 (3H, t), 1.19 (6H, d). δ Present compound 75: Ή -NMR (CDC13) : 8.14-8.10 (2H, m), 7.53 (2H, d), 4.48 (2H, s), 3.36-3.29 (1H, m), 2.84 (3H, s), 1.42 (6H, d). δ Present compound 76: Ή -NMR (CDC13) : 8.12-8.09 (2H, m), 7.55 (2H, d), 4.53 (2H, s), 3.30 (2H, q), 3.24-3.17 (1H, m), 1.40 (6H, d), 1.12 (3H, t). δ Present compound 77: Ή -NMR (CDC13) : 8.10-8.07 (2H, m), 7.59 (2H, d), 4.47 (2H, s), 4.15-4.08 (1H, m), 3.03-2.96 (1H, m), 1.34 (6H, d), 1.17 (6H, d). A compound represented by formula (lo): [Chem.55]

wherein R6, R8, R , and R 10 represent any one combination indicated in the [Table 15]. [Table 15]

δ Present compound 32: Ή -NMR (CDC13) : 8.10-8.07 (2H, m), 7.65-7.63 (1H, m), 7.58-7.54 (1H, m), 4.40 (2H, s), 2.90 (3H, s), 2.81 (3H, s). δ Present compound 78: Ή -NMR (CDC13) : 8.09-8.06 (2H, m), 7.68-7.65 (1H, m), 7.57-7.53 (1H, m), 4.48 (2H, s), 3.30 (2H, q), 2.92 (3H, s), 1.16 (3H, t). [0108] A compound represented by formula (lp): [Chem.56]

wherein R6, R 1 1, and R 12 represent any one combination indicated in the [Table 16]. [Table 16]

δ Present compound 79: Ή -NMR (CDC13) : 8.13-8.10 (2H, m), 7.51 (2H, d), 4.41 (2H, s), 2.87 (6H, s), 2.75 (3H, s). δ Present compound 80: Ή -NMR (CDC13) : 8.12-8.10 (2H, m), 7.53 (2H, d), 4.47 (2H, s), 3.24 (2H, q), 2.82 (6H, s), 1.13 (3H, t). δ Present compound 81: Ή -NMR (CDC13) : 8.10-8.07 (2H, m), 7.57-7.55 (2H, m), 4.42 (2H, s), 4.07-4.01 (1H, m), 2.72 (6H, s), 1.19 (6H, d). δ Present compound 82: Ή -NMR (CDC13) : 8.15-8.13 (2H, m), 7.54-7.52 (2H, m), 6.11-5.81 (1H, m), 4.56 (2H, s), 3.49-3.41 (2H, m), 2.85 (6H, s). δ Present compound 83: Ή -NMR (CDC13) : 8.13-8.11 (2H, m), 7.56-7.54 (2H, m), 4.60 (2H, s), 3.89 (2H, d), 2.91 (6H, s), 2.40 (1H, t).

Present compound 84: Ή -NMR (CDC13) 6: 8.11 (2H, d), 7.54 (2H, d), 4.58 (2H, s), 3.85-3.84 (2H, m), 2.89 (6H, s), 1.88 (3H, t). δ Present compound 85: Ή -NMR (CDC13) : 8.17-8.15 (2H, m), 7.55 (2H, d), 4.60 (2H, s), 4.00 (2H, s), 2.96 (6H, s). [0109] Preparation example 9-1 To a mixture of the Present compound 18 (0.4 g) described in the Preparation example 5-1 and chloroform 10 mL was added triethylamine 0.3 mL at room tem perature, and then was added propionyl chloride 0.12 g, and the resulting mixtures were stirred at room temperature for 20 hours. The reaction mixtures were con centrated under reduced pressure, and the resulting residues were subjected to a silica gel column chromatography (ethyl acetate) to give the Present compound 86 rep resented by the following formula 0.4 g. [Chem.57]

δ Present compound 86: Ή -NMR (CDC13) : 8.19-8.17 (2H, m), 7.59-7.57 (2H, m), 4.83-4.75 (2H, m), 3.08 (3H, s), 2.39 (2H, q), 1.13 (3H, t). [0110] Preparation example 9-2 The compound of the present invention prepared according to the process described in the Preparation example 9-1 and the physical properties thereof are shown below. [0111] A compound represented by formula (lq): [Chem.58]

wherein R7 is any one substituent indicated in the [Table 17]. [Table 17]

δ Present compound 87: Ή -NMR (CDC13) : 8.19-8.16 (2H, m), 7.60-7.57 (2H, m), 4.83-4.74 (2H, m), 3.09 (3H, s), 2.59-2.52 (1H, m), 1.15 (6H, dd). δ Present compound 88: Ή -NMR (CDC13) : 8.24-8.21 (2H, m), 7.62-7.59 (2H, m), 4.88-4.80 (2H, m), 3.22 (3H, s). [0112] [Chem.59]

δ Present compound 89: Ή -NMR (CDC13) : 8.22-8.19 (2H, m), 7.63-7.60 (2H, m), 4.84-4.74 (2H, m), 3.76 (3H, s), 3.05 (3H, s). [0113] Next, Preparation examples of the intermediate compounds for use in preparing the above compounds of the present invention are shown below. [0114] Reference preparation example 1-1 A mixture of the intermediate compound (A2al) 1.7 g described in the Reference preparation example 3-1, ethanol 60 mL, and an aqueous solution of 50%-hydroxylamine 2.2 mL was heated under reflux with stirring for 5 hours. The reaction mixtures were cooled to room temperature and then concentrated under reduced pressure, and then to the mixtures was added water 20 mL, and the mixtures were extracted with ethyl acetate. The organic layers were washed with saturated brine, dried, and concentrated under reduced pressure to give the intermediate compound (Alal) 1.7 g. [Chem.60]

Intermediate compound (Alal): Ή -NMR (DMSO-D ) δ : 9.60 (1H, s), 7.63-7.60 (2H, m), 7.30-7.28 (2H, m), 5.78 (2H, s), 3.69 (2H, s), 1.95 (3H, s). [0115] Reference preparation example 1-2 The intermediate compound prepared according to the process described in the Reference preparation example 1-1 and the physical properties thereof are shown below. [0116] A compound represented by formula (Ala): [Chem.61]

wherein R8, R , and R 10 represent any one combination indicated in the following table. [Table 18]

δ Intermediate compound (Ala2): Ή -NMR (CDC13) : 7.59-7.56 (2H, m), 7.37-7.33 (2H, m), 4.86 (2H, s), 3.73 (2H, s), 2.43 (2H, q), 1.23 (3H, t). δ Intermediate compound (Ala3): Ή -NMR (CDC13) : 7.58-7.56 (2H, m), 7.38-7.36 (2H, m), 4.87 (2H, s), 3.75 (2H, s), 2.81-2.75 (1H, m), 1.25 (6H, d). Intermediate compound (Ala4): Ή -NMR (DMSO-D ) δ : 9.65 (1H, s), 7.65 (2H, d), 7.39 (2H, d), 5.81 (2H, s), 4.32 (2H, s). A compound represented by formula (Alb): [Chem.62]

wherein R8, R , and R 10 represent the combination indicated in the following table. [Table 19]

δ Intermediate compound (Albl): Ή -NMR (CDC13) : 8.25 (1H, s), 7.58-7.57 (1H, m), 7.52-7.51 (1H, m), 7.37-7.36 (2H, m), 4.90 (2H, s), 3.69 (2H, s), 1.99 (3H, s). A compound represented by formula (Ale): [Chem.63]

wherein R6, R8, R , and R10 represent any one combination indicated in the following table. [Table 20]

Intermediate compound (Alel): Ή -NMR (DMSO-D ) δ : 9.61 (IH, s), 7.66-7.64 (2H, m), 7.58 (IH, s), 7.33 (2H, d), 5.80 (2H, s), 4.16 (2H, d), 2.86 (3H, s). Intermediate compound (Ale2): Ή -NMR (DMSO-D ) δ : 9.61 (IH, s), 7.66-7.64 (2H, m), 7.34-7.32 (2H, m), 5.81 (2H, s), 4.14 (2H, d), 2.94 (2H, q), 1.16 (3H, t). Intermediate compound (Ale3): Ή -NMR (DMSO-D ) δ : 9.64 (IH, s), 7.65-7.58 (3H, m), 7.34-7.32 (2H, m), 5.86 (2H, s), 4.17 (2H, d), 3.08 (IH, t), 1.21 (6H, d). Intermediate compound (Ale4): Ή -NMR (DMSO-D ) δ : 9.43-9.19 (IH, m), 7.74-7.64 (3H, m), 7.36 (2H, t), 6.07 (2H, s), 4.20 (2H, d), 2.50-2.44 (IH, m), 1.02-0.97 (2H, m), 0.88-0.87 (2H, m). Intermediate compound (Ale5): Ή -NMR (DMSO-D ) δ : 9.61 (IH, s), 7.66-7.63 (2H, m), 7.33 (2H, d), 5.79 (2H, s), 4.19-4.15 (2H, m), 2.93-2.88 (2H, m), 1.68-1.59 (2H, m), 0.93-0.89 (3H, m). Intermediate compound (Ale6): Ή -NMR (DMSO-D ) δ : 9.64 (IH, s), 7.66-7.60 (3H, m), 7.35-7.32 (2H, m), 5.85 (2H, s), 4.15 (2H, d), 2.93-2.89 (2H, m), 1.62-1.54 (2H, m), 1.36-1.26 (2H, m), 0.84 (3H, t). δ Intermediate compound (Ale7): Ή -NMR (DMSO-D 6) : 9.60 (IH, s), 7.66-7.59 (3H, m), 7.34-7.32 (2H, m), 5.79 (2H, s), 4.15 (2H, d), 2.83 (2H, d), 2.10-2.00 (IH, m), 0.97 (6H, d). δ Intermediate compound (Ale8): -NMR (DMSO-D 6) : 9.60 (IH, s), 7.68 (IH, s), 7.65-7.62 (2H, m), 7.40-7.34 (5H, m), 7.30 (2H, d), 5.79 (2H, s), 4.33 (2H, s), 4.10 (2H, s). δ Intermediate compound (Ale9): -NMR (DMSO-D 6) : 9.63 (IH, s), 7.66 (2H, d), 7.34 (2H, d), 5.80 (2H, s), 4.35 (2H, s), 2.95 (3H, s), 2.48-2.43 (IH, m), 0.64 (4H, d). Intermediate compound (AlelO): Ή -NMR (DMSO-D ) δ : 9.59 (IH, s), 7.56 (2H, d), 7.39-7.31 (4H, m), 7.26-7.23 (3H, m), 5.74 (2H, s), 4.87 (2H, s), 3.09 (3H, s). Intermediate compound (Alell): Ή -NMR (DMSO-D ) δ : 9.61 (IH, s), 7.56-7.54 (2H, m), 7.48-7.46 (IH, m), 7.26-7.20 (IH, m), 7.19-7.14 (4H, m), 5.76 (2H, s), 4.88-4.85 (IH, m), 4.59-4.56 (IH, m), 3.13 (3H, s), 2.02 (3H, s). Intermediate compound (Alel2): Ή -NMR (DMSO-D ) δ : 9.59 (IH, s), 7.57-7.55 (2H, m), 7.26-7.23 (2H, m), 7.21-7.15 (3H, m), 7.07-7.05 (IH, m), 5.75 (2H, s), 4.85 (2H, s), 3.08 (3H, s), 2.26 (3H, s). Intermediate compound (Alel3): Ή -NMR (DMSO-D ) δ : 9.59 (IH, s), 7.56-7.54 (2H, m), 7.26-7.22 (4H, m), 7.13-7.11 (2H, m), 5.75 (2H, s), 4.83 (2H, s), 3.06 (3H, s), 2.24 (3H, s). Intermediate compound (Alel4): Ή -NMR (DMSO-D ) δ : 9.61 (IH, s), 7.57 (2H, d), 7.46-7.42 (IH, m), 7.36-7.30 (IH, m), 7.27-7.21 (3H, m), 7.18-7.14 (IH, m), 5.76 (2H, s), 4.80 (2H, s), 3.17 (3H, s). δ Intermediate compound (Alel5): -NMR (DMSO-D 6) : 9.60 (IH, s), 7.56 (2H, d), 7.29-7.23 (3H, m), 7.09-7.07 (IH, m), 7.04-7.02 (IH, m), 6.83-6.79 (IH, m), 5.76 (2H, s), 4.73 (2H, s), 3.87 (3H, s), 3.07 (3H, s). Intermediate compound (Alel6): Ή -NMR (DMSO-D ) δ : 9.58 (IH, s), 7.64-7.62 (2H, m), 7.38-7.36 (2H, m), 5.77 (2H, s), 4.48 (2H, s), 3.04 (3H, s), 1.34 (9H, s). Intermediate compound (Alel7): Ή -NMR (DMSO-D ) δ : 9.63 (IH, s), 7.68-7.66 (2H, m), 7.39-7.36 (2H, m), 5.81 (2H, s), 4.38 (2H, s), 3.29-3.25 (2H, m), 3.03 (3H, s), 2.49-2.46 (2H, m), 1.97 (3H, s). [0119] A compound represented by formula (A If): [Chem.64]

wherein R6, R8, R , and R 10 represent any one combination indicated in the following table. [Table 21]

δ Intermediate compound (Alfl): Ή -NMR (DMSO-D 6) : 9.64 (IH, s), 7.67 (IH, s), 7.58-7.55 (2H, m), 7.36-7.34 (2H, m), 5.79 (2H, s), 4.16 (2H, s), 2.86 (3H, s). Intermediate compound (AIG): Ή -NMR (DMSO-D ) δ : 9.65 (IH, s), 7.68 (IH, s), 7.62-7.58 (IH, m), 7.57-7.55 (IH, m), 7.36-7.34 (2H, m), 5.79 (2H, s), 4.14 (2H, d), 2.94 (2H, q), 1.16 (3H, t). Intermediate compound (AIG): Ή -NMR (DMSO-D ) δ : 9.64 (IH, s), 7.67 (IH, br s), 7.60-7.54 (2H, m), 7.36-7.34 (2H, m), 5.78 (2H, s), 4.17 (2H, d), 3.10-3.06 (IH, m), 1.21 (6H, d). Intermediate compound (Alf4): Ή -NMR (DMSO-D ) δ : 9.78 (IH, s), 7.69-7.65 (2H, m), 7.58-7.55 (IH, m), 7.41-7.35 (2H, m), 6.08 (2H, s), 4.20 (2H, d), 2.49-2.47 (IH, m), 0.90-0.85 (4H, m). [0120] A compound represented by formula (Alg): [Chem.65] wherein R 1 1 and R 12 represent any one combination indicated in the following table. [Table 22]

Intermediate compound (Algl): Ή -NMR (DMSO-D ) δ : 9.69 (IH, s), 7.67 (2H, d), 7.36 (2H, d), 6.95 (IH, q), 5.87 (2H, s), 4.34 (2H, s), 2.57 (3H, d). Intermediate compound (Alg2): Ή -NMR (DMSO-D ) δ : 9.67 (IH, s), 7.68-7.66 (2H, m), 7.36-7.34 (2H, m), 7.07 (IH, t), 5.83 (2H, s), 4.32 (2H, s), 2.97-2.90 (2H, m), 1.04 (3H, t). δ Intermediate compound (Alg3): Ή -NMR (DMSO-D 6) : 9.68 (IH, s), 7.68-7.65 (2H, m), 7.36 (2H, d), 7.09 (IH, t), 5.86 (2H, s), 4.32 (2H, s), 2.88-2.82 (2H, m), 1.47-1.38 (2H, m), 0.84 (3H, t). δ Intermediate compound (Alg4): Ή -NMR (DMSO-D 6) : 9.67 (IH, s), 7.66 (2H, d), 7.36 (2H, d), 7.21 (IH, t), 5.83 (2H, s), 4.32 (2H, s), 2.80-2.76 (2H, m), 0.91 (IH, d), 0.45-0.41 (2H, m), 0.18-0.15 (2H, m). Intermediate compound (Alg5): Ή -NMR (DMSO-D ) δ : 9.68 (IH, s), 7.69-7.66 (2H, m), 7.41-7.39 (2H, m), 5.84 (2H, s), 4.42 (2H, s), 2.72 (6H, s). Intermediate compound (Alg6): Ή -NMR (DMSO-D ) δ : 9.67 (IH, s), 7.68-7.65 (2H, m), 7.42-7.39 (2H, m), 5.83 (2H, s), 4.44 (2H, s), 3.17-3.14 (4H, m), 1.81-1.77 (4H, m). [0121] [Chem.66]

δ Intermediate compound (Alg7): Ή -NMR (CDC13) : 7.60-7.56 (2H, m), 6.99-6.95 (2H, m), 5.17 (2H, s), 4.83 (2H, s), 2.26 (3H, s). [0122] [Chem.67]

Intermediate compound (Alg8): Ή -NMR (DMSO-D ) δ : 9.99 (IH, s), 8.56 (IH, s), 7.89 (IH, d), 7.84-7.81 (IH, m), 5.87 (2H, s), 4.60 (2H, s), 2.97 (3H, s). [0123] [Chem.68]

δ Intermediate compound (Alg9): Ή -NMR (DMSO-D 6) : 9.63 (IH, s), 7.66 (2H, d), 7.33 (2H, d), 5.81 (2H, s), 4.09 (2H, s), 3.25 (2H, t), 3.08 (2H, t), 2.25-2.18 (2H, m). [Chem.69]

δ Intermediate compound (AlglO): Ή -NMR (DMSO-D 6) : 9.63 (IH, s), 7.66 (2H, d), 7.33 (2H, d), 5.80 (2H, s), 4.26 (2H, s), 3.17 (4H, t), 2.07-2.01 (2H, m), 1.60-1.54 (2H, m). [0125] [Chem.70]

Intermediate compound (Algl l): Ή -NMR (DMSO-D ) δ : 9.60 (IH, s), 8.22 (IH, s), 7.88-7.83 (2H, m), 7.59-7.57 (2H, m), 7.44-7.38 (2H, m), 7.21 (2H, d), 5.77 (2H, s), 4.00 (2H, s). [0126] [Chem.71]

δ Intermediate compound (Algl2): Ή -NMR (DMSO-D 6) : 9.84 (IH, s), 7.57-7.45 (3H, m), 5.93 (2H, s), 4.44 (2H, s), 2.76 (6H, s). [0127] [Chem.72

Intermediate compound (Algl3): Ή -NMR (DMSO-D ) δ : 9.57 (IH, s), 7.68 (IH, s), 7.62-7.60 (2H, m), 7.30 (2H, d), 5.77 (2H, s), 4.09 (2H, s), 2.61 (6H, s). [0128] Reference preparation example 2-1 A mixture of the intermediate compound (A2cl) 1.7 g described in the Reference preparation example 4-1, ethanol 20 mL, and an aqueous solution of 50%-hydroxylamine 1.9 mL was heated under reflux with stirring for 5 hours. The mixtures were cooled to room temperature, and then the precipitates were collected by filtration, and the resulting precipitates were washed with ethanol 50 mL and dried under reduced pressure to give the intermediate compound (Alcl) 1.2 g. [Chem.73]

Intermediate compound (Alcl): Ή -NMR (DMSO-D ) δ : 9.70 (IH, s), 7.70-7.68 (2H, m), 7.41-7.39 (2H, m), 5.84 (2H, s), 4.50 (2H, s), 2.91 (3H, s). Reference preparation example 2-2 The intermediate compound prepared according to the process described in the Reference preparation example 2-1 and the physical properties thereof are shown below. A compound represented by formula (Ale): [Chem.74]

wherein R8, R , R10, R2 1, and R22 represent any one combination indicated in the following table. [Table 23]

Intermediate compound (Alc2): Ή -NMR (DMSO-D ) δ : 9.86 (IH, s), 7.58-7.56 (IH, m), 7.54-7.51 (IH, m), 7.48-7.44 (IH, m), 5.94 (2H, s), 4.56 (2H, s), 3.01 (3H, s). Intermediate compound (Alc3): Ή -NMR (DMSO-D ) δ : 9.70 (IH, s), 7.55-7.51 (IH, m), 7.29-7.24 (2H, m), 5.85 (2H, s), 4.55 (2H, s), 2.94 (3H, s). [0130] A compound represented by formula (Aid): [Chem.75]

wherein R8, R , and R 10 represent the combination indicated in the following table. [Table 24]

δ Intermediate compound (Aldl): Ή -NMR (DMSO-D 6) : 9.68 (IH, s), 7.74-7.72 (IH, m), 7.67-7.64 (IH, m), 7.42-7.40 (2H, m), 5.82 (2H, s), 4.49 (2H, s), 2.91 (3H, s). [0131] Reference preparation example 3-1 A mixture of 4-(bromomethyl)benzonitrile 2.0 g, ethanol 50 mL, and sodium methanethiolate 0.72 g was heated under reflux with stirring for 5 hours. The reaction mixtures were cooled to room temperature, and then to the reaction mixtures was added water 20 mL, and then the resulting mixtures were extracted with diethyl ether. The organic layers were washed with saturated brine, dried, and concentrated under reduced pressure to give the intermediate compound (A2al) 1.7 g. [Chem.76]

δ Intermediate compound (A2al): Ή -NMR (CDC13) : 7.63-7.61 (2H, m), 7.43-7.41 (2H, m), 3.70 (2H, s), 1.99 (3H, s). [0132] Reference preparation example 3-2 The intermediate compound prepared according to the process described in the Reference preparation example 3-1 and the physical properties thereof are shown below. A compound represented by formula (A2a): [Chem.77]

wherein R8, R , and R 10 represent any one combination indicated in the following table. [Table 25]

δ Intermediate compound (A2a2): Ή -NMR (CDC13) : 7.62-7.60 (2H, m), 7.44-7.42 (2H, m), 3.74 (2H, s), 2.42 (2H, q), 1.23 (3H, t). δ Intermediate compound (A2a3): Ή -NMR (CDC13) : 7.61-7.59 (2H, m), 7.45-7.44 (2H, m), 3.76 (2H, s), 2.80-2.73 (1H, m), 1.25 (6H, d). A compound represented by formula (A2b): [Chem.78

wherein R8, R , and R 10 represent the combination indicated in the following table. [Table 26]

δ Intermediate compound (A2bl): Ή -NMR (CDC13) : 7.62-7.61 (1H, m), 7.57-7.56 (1H, m), 7.55-7.54 (1H, m), 7.45-7.41 (1H, m), 3.68 (2H, s), 2.00 (3H, s). Reference preparation example 4-1 A mixture of 4-(bromomethyl)benzonitrile 1.5 g, l-methyl-2-pyrrolidone 50 mL, and sodium methanesulfinate 0.78 g was stirred at 100°C for 10 hours. The reaction mixtures were cooled to room temperature, and then to the reaction mixtures was added water 100 mL, and the reaction mixtures were extracted with ethyl acetate. The organic layers were washed with saturated brine, dried, and concentrated under reduced pressure to give the intermediate compound (A2cl) 1.8 g. [Chem.79]

δ Intermediate compound (A2cl): Ή -NMR (CDC13) : 7.73 (2H, d), 7.56 (2H, d), 4.31 (2H, s), 2.85 (3H, s). Reference preparation example 4-2 The intermediate compound prepared according to the process described in the Reference preparation example 4-1 and the physical properties thereof are shown below. A compound represented by formula (A2c): [Chem.80]

wherein R8, R , R 10, R2 1, and R22 represent any one combination indicated following table. [Table 27]

Intermediate compound (A2c2): Ή -NMR (DMSO-D ) δ : 7.97-7.95 (1H, m), 7.79-7.77 (1H, m), 7.70-7.66 (1H, m), 4.69 (2H, s), 3.06 (3H, s). Intermediate compound (A2c3): Ή -NMR (DMSO-D ) δ : 8.02-7.98 (1H, m), 7.58-7.56 (1H, m), 7.48-7.45 (1H, m), 4.68 (2H, s), 2.97 (3H, s). A compound represented by formula (A2d): [Chem.81]

wherein R8, R , and R 10 represent the combination indicated in the following table. [Table 28] To R ' R Intermediate compound (A2dl) H H δ Intermediate compound (A2dl): Ή -NMR (CDC13) : 7.74-7.69 (3H, m), 7.57 (1H, t), 4.29 (2H, s), 2.86 (3H, s). [Chem.82

δ Intermediate compound (A2d2): Ή -NMR (DMSO-D 6) : 8.76-8.75 (1H, 8.12-8.07 (2H, m), 4.73 (2H, s), 3.01 (3H, s). Reference preparation example 5-1 To a mixture of 4-(aminomethyl)benzonitrile 1.0 g and tetrahydrofuran 20 mL were added successively methanesulfonyl chloride 1.0 mL and triethylamine 1.6 mL at room temperature, and then the mixture was stirred for 10 hours. To the reaction mixtures was added water 20 mL, and the reaction mixtures were extracted with ethyl acetate. The organic layers were washed with saturated brine, dried, and concentrated under reduced pressure to give the intermediate compound (A2el) 1.1 g. [Chem.83]

Intermediate compound (A2el): Ή -NMR (DMSO-D ) δ : 7.85-7.82 (2H, m), 7.76 (1H, br s), 7.56-7.54 (2H, m), 4.26 (2H, s), 2.92 (3H, s). Reference preparation example 5-2 The intermediate compound prepared according to the process described in the Reference preparation example 5-1 and the physical properties thereof are shown below. A compound represented by formula (A2e): Chem.84]

(A2e) wherein R6, R8, R , and R 10 represent any one combination indicated in the following table. [Table 29]

δ Intermediate compound (A2e2): Ή -NMR (CDC13) : 7.68-7.66 (2H, m), 7.50-7.48 (2H, m), 4.66 (1H, br s), 4.38 (2H, d), 3.02 (2H, q), 1.37 (3H, t). δ Intermediate compound (A2e3): Ή -NMR (CDC13) : 7.68-7.66 (2H, m), 7.50-7.48 (2H, m), 4.41 (3H, br s), 3.16-3.13 (1H, m), 1.39 (6H, d). δ Intermediate compound (A2e4): -NMR (CDC13) : 7.67-7.63 (2H, m), 7.52-7.49 (2H, m), 5.15 (1H, s), 4.42-4.39 (2H, m), 2.40-2.33 (1H, m), 1.16-1.11 (2H, m), 1.00-0.93 (2H, m). δ Intermediate compound (A2e5): -NMR (CDC13) : 7.68-7.66 (2H, m), 7.50-7.48 (2H, m), 4.65-4.64 (1H, m), 4.38 (2H, d), 2.99-2.95 (2H, m), 1.89-1.80 (2H, m), 1.04 (3H, t). δ Intermediate compound (A2e6): Ή -NMR (CDC13) : 7.68-7.65 (2H, m), 7.50-7.48 (2H, m), 4.74 (1H, t), 4.38 (2H, d), 3.00-2.96 (2H, m), 1.81-1.73 (2H, m), 1.47-1.38 (2H, m), 0.93 (3H, t). δ Intermediate compound (A2e7): Ή -NMR (CDC13) : 7.67 (2H, d), 7.49 (2H, d), 4.70-4.67 (1H, m), 4.37 (2H, d), 2.89 (2H, d), 2.30-2.20 (1H, m), 1.09 (6H, d). A compound represented by formula (A2f): [Chem.85]

wherein R6, R8, R , and R 10 represent any one combination indicated in the following table. [Table 30]

δ Intermediate compound (A2f 1): Ή -NMR (CDC13) : 7.67-7.62 (3H, m), 7.53-7.48 (1H, m), 4.76 (1H, br s), 4.38 (2H, d), 2.96 (3H, s). δ Intermediate compound (A2f2): Ή -NMR (CDC13) : 7.66-7.60 (3H, m), 7.52-7.47 (1H, m), 5.04 (1H, s), 4.36-4.34 (2H, m), 3.04-2.98 (2H, m), 1.38-1.33 (3H, m). δ Intermediate compound (A2f3): Ή -NMR (CDC13) : 7.66-7.59 (3H, m), 7.51-7.47 (1H, m), 4.84 (1H, s), 4.36 (2H, s), 3.17-3.10 (1H, m), 1.38 (6H, d). δ Intermediate compound (A2f4): Ή -NMR (CDC13) : 7.69-7.67 (1H, m), 7.65-7.58 (2H, m), 7.51-7.45 (1H, m), 5.01 (1H, s), 4.39-4.38 (2H, m), 2.42-2.34 (1H, m), 1.18-1.10 (2H, m), 1.04-0.93 (2H, m). [Chem.86]

δ Intermediate compound (A2f5): Ή -NMR (CDC13) : 7.68-7.64 (2H, m), 7.49-7.47 (2H, m), 4.61 (1H, s), 4.30 (2H, d), 2.78 (6H, s). Reference preparation example 6-1 To a mixture of (4-cyanophenyl)methanesulfonyl chloride 0.5 g and tetrahydrofuran 5 mL was added propylamine 0.27 g at 0°C, and then the mixture was stirred at room temperature for 5 hours. To the reaction mixtures was added water 10 mL, and the reaction mixtures were extracted with ethyl acetate. The organic layers were washed with saturated brine, dried, and concentrated under reduced pressure, and the resulting residues were subjected to a silica gel column chromatography to give the intermediate compound (A2g3) 0.4 g. Chem.87]

δ Intermediate compound (A2g3): Ή -NMR (CDC13) : 7.71-7.68 (2H, m), 7.54-7.52 (2H, m), 4.29 (2H, s), 4.21 (1H, t), 3.02-2.97 (2H, m), 1.59-1.49 (2H, m), 0.92 (3H, t). Reference preparation example 6-2 The intermediate compound prepared according to the process described in the Reference preparation example 6-1 and the physical properties thereof are shown below. A compound represented by formula (A2g): [Chem.88]

wherein R 1 1 and R 12 represent any one combination indicated in the following table. [Table 31]

δ Intermediate compound (A2gl): Ή -NMR (CDC13) : 7.70 (2H, d), 7.53 (2H, d), 4.30 (2H, s), 4.20 (1H, br s), 2.75-2.73 (3H, m). δ Intermediate compound (A2g2): Ή -NMR (CDC13) : 7.70-7.68 (2H, m), 7.54-7.52 (2H, m), 4.29 (2H, s), 3.11-3.04 (2H, m), 1.17 (3H, t). δ Intermediate compound (A2g4): Ή -NMR (CDC13) : 7.71-7.68 (2H, m), 7.55-7.52 (2H, m), 4.31 (2H, s), 2.89 (2H, dd), 1.01-0.94 (1H, m), 0.59-0.54 (2H, m), 0.22-0.18 (2H, m). δ Intermediate compound (A2g5): Ή -NMR (CDC13) : 7.70 (2H, d), 7.54 (2H, d), 4.24 (2H, s), 2.80 (6H, s). δ Intermediate compound (A2g6): Ή -NMR (CDC13) : 7.70-7.67 (2H, m), 7.55-7.52 (2H, m), 4.27 (2H, s), 3.24-3.21 (4H, m), 1.89-1.86 (4H, m). [Chem.89]

δ Intermediate compound (A2g7): Ή -NMR (CDC13) : 7.67 (1H, t), 7.53-7.50 (1H, m), 7.45-7.42 (1H, m), 4.32-4.31 (2H, m), 2.81 (6H, s). Reference preparation example 7-1 To a mixture of N-cyclopropylmethanesulfonamide 0.3 g and N,N-dimethylformamide 20 mL was added sodium hydride (60%, oily) 0.1 g at 0°C, and the mixture was stirred for 0.5 hours. To the reaction mixtures was added 4-cyanobenzyl bromide 0.5 g, and the mixtures were stirred at room temperature for 12 hours. To the reaction mixtures was added water 10 mL, and the reaction mixtures were extracted with ethyl acetate. The organic layers were washed with saturated brine, dried, and concentrated under reduced pressure, and the resulting residues were subjected to a silica gel column chro matography to give the intermediate compound (A2e8) 0.4 g. [Chem.90]

δ Intermediate compound (A2e8): Ή -NMR (CDC13) : 7.67-7.65 (2H, m), 7.53-7.51 (2H, m), 4.47 (2H, s), 2.89 (3H, s), 2.42-2.37 (1H, m), 0.81-0.76 (4H, m). Reference preparation example 7-2 The intermediate compound prepared according to the process described in the Reference preparation example 7-1 and the physical properties thereof are shown below. A compound represented by formula (A2e): [Chem.91]

wherein R6, R8, R , and R 10 represent any one combination indicated in the following table. [Table 32] δ Intermediate compound (A2e9): Ή -NMR (CDC13) : 7.58-7.56 (2H, m), 7.41-7.39 (2H, m), 7.37-7.30 (3H, m), 7.28-7.25 (2H, m), 4.91 (2H, s), 2.98 (3H, s). δ Intermediate compound (A2el0): Ή -NMR (CDC13) : 7.58-7.55 (2H, m), 7.36-7.34 (2H, m), 7.25-7.19 (3H, m), 7.16-7.14 (1H, m), 4.83-4.69 (2H, m), 2.99 (3H, s), 2.12 (3H, s). δ Intermediate compound (A2ell): Ή -NMR (CDC13) : 7.59-7.56 (2H, m), 7.42-7.40 (2H, m), 7.24-7.21 (1H, m), 7.11-7.04 (3H, m), 4.89 (2H, s), 2.97 (3H, s), 2.32 (3H, s). δ Intermediate compound (A2el2): Ή -NMR (CDC13) : 7.58-7.55 (2H, m), 7.41-7.39 (2H, m), 7.13 (4H, s), 4.87 (2H, s), 2.96 (3H, s), 2.31 (3H, s). δ Intermediate compound (A2el3): Ή -NMR (CDC13) : 7.59-7.57 (2H, m), 7.51-7.48 (1H, m), 7.42 (2H, d), 7.33-7.31 (1H, m), 7.18-7.14 (1H, m), 7.09-7.06 (1H, m), 4.85 (2H, s), 3.04 (3H, d). δ Intermediate compound (A2el4): Ή -NMR (CDC13) : 7.57-7.54 (2H, m), 7.40 (2H, d), 7.31-7.27 (1H, m), 7.09-7.07 (1H, m), 6.96-6.93 (1H, m), 6.87-6.83 (1H, m), 4.82 (2H, s), 3.93 (3H, s), 2.99 (3H, s). δ Intermediate compound (A2el5): -NMR (CDC13) : 7.65-7.63 (2H, m), 7.54-7.51 (2H, m), 4.57 (2H, s), 3.01 (3H, s), 1.43 (9H, s). δ Intermediate compound (A2el6): -NMR (CDC13) : 7.64 (2H, d), 7.50 (2H, d), 4.39 (2H, s), 4.24-4.33 (1H, m), 2.90 (3H, s), 1.36-1.90 (8H, m) δ Intermediate compound (A2el7): -NMR (CDC13) : 7.63 (2H, d), 7.53 (2H, d), 4.42 (2H, s), 3.69-3.76 (1H, m), 2.88 (3H, s), 1.77 (4H, d), 1.58-1.64 (1H, m), 1.28-1.33 (5H, m). δ Intermediate compound (A2el8): Ή -NMR (CDC13) : 7.69-7.66 (2H, m), 7.52-7.50 (2H, m), 4.48 (2H, s), 3.40 (2H, t), 2.99 (3H, s), 2.56 (2H, t), 2.07 (3H, s). Chem.92]

δ Intermediate compound (A2el9): Ή -NMR (CDC13) : 7.67-7.65 (2H, m), 7.49-7.47 (2H, m), 4.36 (2H, s), 3.23 (2H, t), 3.12 (2H, t), 2.28-2.22 (2H, m), 1.70-1.64 (2H, m). Reference preparation example 8-1 To a mixture of 4-cyanophenol 2.0 g and N,N-dimethylformamide 40 mL was added sodium hydride (60%, oily) 0.8 g at 0°C, and the mixture was stirred for 0.5 hours. To the reaction mixtures was added chloromethylmethylsulfide 2.4 g, and the reaction mixtures were stirred at room temperature for 12 hours. To the reaction mixtures was added water 20 mL, and the reaction mixtures were extracted with ethyl acetate. The organic layers were washed with saturated brine, dried, and concentrated under reduced pressure, and the resulting residues were subjected to a silica gel column chro matography to give the intermediate compound (A2hl) 3.0 g. [Chem.9

H3C δ Intermediate compound (A2hl): Ή -NMR (CDC13) : 7.62-7.60 (2H, m), 7.02-7.00 (2H, m), 5.19 (2H, s), 2.26 (3H, s). [0149] In the present description, Me represents a methyl group, Et represents an ethyl group, Pr represents a propyl group, i-Pr represents an isopropyl group, c-Pr represents a cyclopropyl group, Bu represents a butyl group, i-Bu represents an isobutyl group, t- Bu represents a tert-butyl group, c-Pentyl represents a cyclopentyl group, c-Hexyl represents a cyclohexyl group, Ph represents a phenyl group, Bn represents a benzyl group, and Py represents a pyridyl group. [0150] The compound represented by formula (II): [Chem.94]

[wherein R2 1, R22, R23, and R24 are independently of each other a hydrogen atom or a sub stituent indicated in Group I; and R25 is a C1-C6 alkyl group optionally having one or more substituents selected from the group consisting of Group A and Group F, a C3-C6 cycloalkyl group optionally having one or more halogen atoms, or a phenyl group optionally having one or more halogen atoms] wherein R2 1, R22, R23, R24 , and R25 represent any one combination indicated in the following substituent numbers RAl to RAl 12 (hereinafter the compounds of the sub stituent numbers RAl to RAl 12 are referred to as "Present compounds RAl to RAl 12", and the "Present compounds RAl to RAl 12" are collectively referred to as "Present compound RA") can be prepared according to the method described in the above processes. The substituent numbers RAl to RAl 12 as described herein represent the combinations of R2 1, R22, R23, R24 , and R25 in the compound represented by formula (II), and hereinafter are indicated by [substituent number;R 2 1,R22,R2 ,R24 ,R25]. For example, the substituent number RA4 represents the combination wherein R2 1, R22, R23, and R24 are each a hydrogen atom, and R25 is an isopropyl group. For example, the Present compound RA4 indicates the compound represented by formula (II) wherein the substituent number is RA4, and indicates the compound rep resented by formula (II) wherein R2 1, R22, R23, and R24 are each a hydrogen atom, and R 25 is an isopropyl group as shown in the following. [Chem.95]

[Substituent number;R ,R ,R ,R ,R25]: [RA 1;H,H,H,H,Me] , [RA2;H,H,H,H,Et], [RA3;H,H,H,H,Pr], [RA4;H,H,H,H,i-Pr], [RA5;H,H,H,H,c-Pr], [RA6;H,H,H,H,Bu],

[RA7;H,H,H,H,i-Bu], [RA8;H,H,H,H,t-Bu], [RA9;H,H,H,H,c-PrCH 2],

[RA10;H,H,H,H,Ph], [RA 11;H,H,H,H,Bn] , [RA12;H,H,H,H,CF 3],

[RA 13;H,H,H,H,CF 3CH2], [RA 14;H,H,H,H,CF 3CF2], [RA 15;H,H,H,H,CF 2H],

[RA16;H,H,H,H,CF 2HCH 2], [RA 17;F,H,H,H,Me] , [RA 18;F,H,H,H,Et] , [RA19;F,H,H,H,Pr], [RA20;F,H,H,H,i-Pr], [RA21;F,H,H,H,c-Pr], [RA22;F,H,H,H,Bu], [RA23;F,H,H,H,i-Bu], [RA24;F,H,H,H,t-Bu],

[RA25;F,H,H,H,c-PrCH 2], [RA26;F,H,H,H,Ph], [RA27 ;F,H,H,H,Bn] ,

[RA28 ;F,H,H,H,CF 3], [RA29;F,H,H,H,CF 3CH2], [RA30;F,H,H,H,CF 3CF2],

[RA31;F,H,H,H,CF 2H], [RA32;F,H,H,H,CF 2HCH 2], [RA33;H,F,H,H,Me], [RA34;H,F,H,H,Et], [RA35;H,F,H,H,Pr], [RA36;H,F,H,H,i-Pr], [RA37;H,F,H,H,c-Pr], [RA38;H,F,H,H,Bu], [RA39;H,F,H,H,i-Bu], [RA40;H,F,H,H,t-Bu],

[RA41;H,F,H,H,c-PrCH 2], [RA42;H,F,H,H,Ph], [RA43 ;H,F,H,H,Bn] ,

[RA44;H,F,H,H,CF 3], [RA45 ;H,F,H,H,CF 3CH2], [RA46 ;H,F,H,H,CF 3CF2],

[RA47;H,F,H,H,CF 2H], [RA48;H,F,H,H,CF 2HCH 2], [RA49;F,F,H,H,Me], [RA50;F,F,H,H,Et], [RA51;F,F,H,H,Pr], [RA52;F,F,H,H,i-Pr], [RA53;F,F,H,H,c-Pr], [RA54;F,F,H,H,Bu], [RA55;F,F,H,H,i-Bu], [RA56;F,F,H,H,t-Bu],

[RA57;F,F,H,H,c-PrCH 2], [RA58;F,F,H,H,Ph], [RA59;F,F,H,H,Bn],

[RA60;F,F,H,H,CF 3], [RA6 1;F,F,H,H,CF 3CH2], [RA62;F,F,H,H,CF 3CF2],

[RA63;F,F,H,H,CF 2H], [RA64;F,F,H,H,CF 2HCH 2], [RA65 ;F,H,F,H,Me] , [RA66;F,H,F,H,Et], [RA67;F,H,F,H,Pr], [RA68;F,H,F,H,i-Pr], [RA69;F,H,F,H,c-Pr], [RA70;F,H,F,H,Bu], [RA71;F,H,F,H,i-Bu], [RA72;F,H,F,H,t-Bu],

[RA73;F,H,F,H,c-PrCH 2], [RA74;F,H,F,H,Ph], [RA75 ;F,H,F,H,Bn] , [RA76;F,H,F,H,CF 3], [RA77;F,H,F,H,CF 3CH2], [RA78;F,H,F,H,CF 3CF2],

[RA79;F,H,F,H,CF 2H], [RA80;F,H,F,H,CF 2HCH 2], [RA8 1;F,H,H,F,Me] , [RA82;F,H,H,F,Et] , [RA83;F,H,H,F,Pr], [RA84;F,H,H,F,i-Pr], [RA85;F,H,H,F,c-Pr], [RA86;F,H,H,F,Bu], [RA87;F,H,H,F,i-Bu], [RA88;F,H,H,F,t-Bu],

[RA89;F,H,H,F,c-PrCH 2], [RA90;F,H,H,F,Ph], [RA9 1;F,H,H,F,Bn] ,

[RA92;F,H,H,F,CF 3], [RA93 ;F,H,H,F,CF 3CH2], [RA94;F,H,H,F,CF 3CF2],

[RA95;F,H,H,F,CF 2H], [RA96;F,H,H,F,CF 2HCH 2], [RA97 ;H,F,H,F,Me] , [RA98;H,F,H,F,Et], [RA99;H,F,H,F,Pr], [RA100;H,F,H,F,i-Pr], [RA101;H,F,H,F,c-Pr], [RA102;H,F,H,F,Bu], [RA103;H,F,H,F,i-Bu],

[RA104;H,F,H,F,t-Bu], [RA105;H,F,H,F,c-PrCH 2], [RA106;H,F,H,F,Ph],

[RA 107;H,F,H,F,Bn] , [RA 108;H,F,H,F,CF 3], [RA 109;H,F,H,F,CF 3CH2],

[RA1 10;H,F,H,F,CF 3CF2], [RA1 11;H,F,H,F,CF 2H], [RA1 12;H,F,H,F,CF 2HCH 2] The compound represented by formula (III) [Chem.96]

(wherein R2 1, R22, R23, R24, and R25 are the same as defined above) wherein R2 1, R22, R23, R24 , and R25 represent any one combination indicated in the following substituent numbers RBI to RBI 12 (hereinafter the compounds of the sub stituent numbers RBI to RBI 12 are referred to as "Present compounds RBI to RBI 12", and the "Present compounds RBI to RBI 12" are collectively referred to as "Present compound RB") can be prepared according to the method described in the above processes. The substituent numbers RBI to RBI 12 as described herein represent the com binations of R2 1, R22, R23, R24 , and R25 in the compound represented by formula (III), and hereinafter are indicated by [substituent number;R 2 1,R22,R2 ,R24,R25]. For example, the substituent number RB4 represents the combination wherein R2 1, R 22, R23, and R24 are each a hydrogen atom, and R25 is an isopropyl group. For example, the Present compound RB4 indicates the compound represented by formula (III) wherein the substituent number is RB4, and indicates the compound rep resented by formula (III) wherein R2 1, R22, R23, and R24 are each a hydrogen atom, and R25 is an isopropyl group as shown in the following. [Chem.97]

[Substituent number;R2 1,R22,R2 ,R24,R25]: [RB 1;H,H,H,H,Me] , [RB2;H,H,H,H,Et] , [RB3;H,H,H,H,Pr], [RB4;H,H,H,H,i-Pr], [RB5;H,H,H,H,c-Pr], [RB6;H,H,H,H,Bu],

[RB7;H,H,H,H,i-Bu], [RB8;H,H,H,H,t-Bu], [RB9;H,H,H,H,c-PrCH2],

[RB10;H,H,H,H,Ph], [RB 11;H,H,H,H,Bn], [RB12;H,H,H,H,CF3], [RB13;H,H,H,H,CF 3CH2], [RB14;H,H,H,H,CF3CF2], [RB15;H,H,H,H,CF2H], [RB16;H,H,H,H,CF2HCH2], [RB17;F,H,H,H,Me], [RB 18;F,H,H,H,Et], [RB19;F,H,H,H,Pr], [RB20;F,H,H,H,i-Pr], [RB21;F,H,H,H,c-Pr], [RB22;F,H,H,H,Bu], [RB23;F,H,H,H,i-Bu],

[RB24;F,H,H,H,t-Bu], [RB25;F,H,H,H,c-PrCH2], [RB26;F,H,H,H,Ph],

[RB27;F,H,H,H,Bn], [RB28;F,H,H,H,CF3], [RB29;F,H,H,H,CF3CH2],

[RB30;F,H,H,H,CF3CF2], [RB31;F,H,H,H,CF2H], [RB32;F,H,H,H,CF2HCH2], [RB33;H,F,H,H,Me], [RB34;H,F,H,H,Et], [RB35;H,F,H,H,Pr], [RB36;H,F,H,H,i-Pr], [RB37;H,F,H,H,c-Pr], [RB38;H,F,H,H,Bu], [RB39;H,F,H,H,i-Bu],

[RB40;H,F,H,H,t-Bu], [RB41;H,F,H,H,c-PrCH2], [RB42;H,F,H,H,Ph],

[RB43;H,F,H,H,Bn], [RB44;H,F,H,H,CF3], [RB45;H,F,H,H,CF3CH2],

[RB46;H,F,H,H,CF3CF2], [RB47;H,F,H,H,CF2H], [RB48;H,F,H,H,CF2HCH2], [RB49;F,F,H,H,Me], [RB50;F,F,H,H,Et], [RB51;F,F,H,H,Pr], [RB52;F,F,H,H,i-Pr], [RB53;F,F,H,H,c-Pr], [RB54;F,F,H,H,Bu], [RB55;F,F,H,H,i-Bu],

[RB56;F,F,H,H,t-Bu], [RB57;F,F,H,H,c-PrCH2], [RB58;F,F,H,H,Ph],

[RB59;F,F,H,H,Bn], [RB60;F,F,H,H,CF3], [RB61;F,F,H,H,CF3CH2],

[RB62;F,F,H,H,CF3CF2], [RB63;F,F,H,H,CF2H], [RB64;F,F,H,H,CF2HCH2], [RB65;F,H,F,H,Me], [RB66;F,H,F,H,Et], [RB67;F,H,F,H,Pr], [RB68;F,H,F,H,i-Pr], [RB69;F,H,F,H,c-Pr], [RB70;F,H,F,H,Bu], [RB71;F,H,F,H,i-Bu],

[RB72;F,H,F,H,t-Bu], [RB73;F,H,F,H,c-PrCH2], [RB74;F,H,F,H,Ph],

[RB75;F,H,F,H,Bn], [RB76;F,H,F,H,CF3], [RB77;F,H,F,H,CF3CH2],

[RB78;F,H,F,H,CF3CF2], [RB79;F,H,F,H,CF2H], [RB80;F,H,F,H,CF2HCH2], [RB81;F,H,H,F,Me], [RB82;F,H,H,F,Et], [RB83;F,H,H,F,Pr], [RB84;F,H,H,F,i-Pr], [RB85;F,H,H,F,c-Pr], [RB86;F,H,H,F,Bu], [RB87;F,H,H,F,i-Bu],

[RB88;F,H,H,F,t-Bu], [RB89;F,H,H,F,c-PrCH2], [RB90;F,H,H,F,Ph],

[RB9 1;F,H,H,F,Bn], [RB92;F,H,H,F,CF3], [RB93;F,H,H,F,CF3CH2],

[RB94;F,H,H,F,CF3CF2], [RB95;F,H,H,F,CF2H], [RB96;F,H,H,F,CF2HCH2], [RB97;H,F,H,F,Me], [RB98;H,F,H,F,Et], [RB99;H,F,H,F,Pr], [RB100;H,F,H,F,i-Pr], [RB101;H,F,H,F,c-Pr], [RB102;H,F,H,F,Bu], [RB103;H,F,H,F,i-Bu], [RB104;H,F,H,F,t-Bu], [RB105;H,F,H,F,c-PrCH 2], [RB106;H,F,H,F,Ph],

[RB107;H,F,H,F,Bn], [RB108;H,F,H,F,CF 3], [RB109;H,F,H,F,CF 3CH2],

[RB110;H,F,H,F,CF 3CF2], [RB 111 ;H,F,H,F,CF 2H], [RBI 12;H,F,H,F,CF 2HCH 2] The compound represented by formula (IV): [Chem.98]

(wherein R2 1, R22, R23, R24, and R25 are the same as defined above) wherein R2 1, R22, R23, R24 , and R25 represent any one combination indicated in the following substituent numbers RC1 to RC1 12 (hereinafter the compounds of the sub stituent numbers RC1 to RC1 12 are referred to as "Present compounds RC1 to RC1 12", and the "Present compounds RC1 to RC1 12" are collectively referred to as "Present compound RC") can be prepared according to the method described in the above processes. The substituent numbers RC1 to RC1 12 as described herein represent the com binations of R2 1, R22, R23, R24 , and R25 in the compound represented by formula (IV), and hereinafter are indicated by [substituent number;R 2 1,R22,R2 ,R24,R25]. For example, the substituent number RC4 represents the combination wherein R2 1, R 22, R23, and R24 are each a hydrogen atom, and R25 is an isopropyl group. For example, the Present compound RC4 indicates the compound represented by formula (IV) wherein the substituent number is RC4, and indicates the compound rep resented by formula (IV) wherein R2 1, R22, R23, and R24 are each a hydrogen atom, and R25 is an isopropyl group as shown in the following. [Chem.99]

[Substituent number;R ,R ,R ,R ,R25]: [RCl;H,H,H,H,Me], [RC2;H,H,H,H,Et], [RC3;H,H,H,H,Pr], [RC4;H,H,H,H,i-Pr], [RC5;H,H,H,H,c-Pr], [RC6;H,H,H,H,Bu],

[RC7;H,H,H,H,i-Bu], [RC8;H,H,H,H,t-Bu], [RC9;H,H,H,H,c-PrCH 2],

[RC10;H,H,H,H,Ph], [RCll;H,H,H,H,Bn], [RC12;H,H,H,H,CF 3], [RC13;H,H,H,H,CF

3CH2], [RC14;H,H,H,H,CF 3CF2], [RC15;H,H,H,H,CF 2H], [RC16;H,H,H,H,CF 2HCH 2], [RC17;F,H,H,H,Me], [RC18;F,H,H,H,Et], [RC19;F,H,H,H,Pr], [RC20;F,H,H,H,i-Pr], [RC21;F,H,H,H,c-Pr], [RC22;F,H,H,H,Bu], [RC23;F,H,H,H,i-Bu],

[RC24;F,H,H,H,t-Bu], [RC25;F,H,H,H,c-PrCH 2], [RC26;F,H,H,H,Ph],

[RC27;F,H,H,H,Bn], [RC28;F,H,H,H,CF 3], [RC29;F,H,H,H,CF 3CH2],

[RC30;F,H,H,H,CF 3CF2], [RC3 1;F,H,H,H,CF2H], [RC32;F,H,H,H,CF 2HCH2], [RC33;H,F,H,H,Me], [RC34;H,F,H,H,Et], [RC35;H,F,H,H,Pr], [RC36;H,F,H,H,i-Pr], [RC37;H,F,H,H,c-Pr], [RC38;H,F,H,H,Bu], [RC39;H,F,H,H,i-Bu],

[RC40;H,F,H,H,t-Bu], [RC41;H,F,H,H,c-PrCH 2], [RC42;H,F,H,H,Ph],

[RC43;H,F,H,H,Bn], [RC44;H,F,H,H,CF 3], [RC45;H,F,H,H,CF 3CH2],

[RC46;H,F,H,H,CF3CF2], [RC47;H,F,H,H,CF2H], [RC48;H,F,H,H,CF2HCH2], [RC49;F,F,H,H,Me], [RC50;F,F,H,H,Et], [RC51;F,F,H,H,Pr], [RC52;F,F,H,H,i-Pr], [RC53;F,F,H,H,c-Pr], [RC54;F,F,H,H,Bu], [RC55;F,F,H,H,i-Bu],

[RC56;F,F,H,H,t-Bu], [RC57;F,F,H,H,c-PrCH 2], [RC58;F,F,H,H,Ph],

[RC59;F,F,H,H,Bn], [RC60;F,F,H,H,CF 3], [RC61;F,F,H,H,CF 3CH2],

[RC62;F,F,H,H,CF 3CF2], [RC63;F,F,H,H,CF2H], [RC64;F,F,H,H,CF 2HCH2], [RC65;F,H,F,H,Me], [RC66;F,H,F,H,Et], [RC67;F,H,F,H,Pr], [RC68;F,H,F,H,i-Pr], [RC69;F,H,F,H,c-Pr], [RC70;F,H,F,H,Bu], [RC71;F,H,F,H,i-Bu],

[RC72;F,H,F,H,t-Bu], [RC73;F,H,F,H,c-PrCH 2], [RC74;F,H,F,H,Ph],

[RC75;F,H,F,H,Bn], [RC76;F,H,F,H,CF 3], [RC77;F,H,F,H,CF 3CH2],

[RC78;F,H,F,H,CF 3CF2], [RC79;F,H,F,H,CF 2H], [RC80;F,H,F,H,CF 2HCH2], [RC81;F,H,H,F,Me], [RC82;F,H,H,F,Et], [RC83;F,H,H,F,Pr], [RC84;F,H,H,F,i-Pr], [RC85;F,H,H,F,c-Pr], [RC86;F,H,H,F,Bu], [RC87;F,H,H,F,i-Bu],

[RC88;F,H,H,F,t-Bu], [RC89;F,H,H,F,c-PrCH 2], [RC90;F,H,H,F,Ph],

[RC91;F,H,H,F,Bn], [RC92;F,H,H,F,CF 3], [RC93;F,H,H,F,CF 3CH2],

[RC94;F,H,H,F,CF 3CF2], [RC95;F,H,H,F,CF2H], [RC96;F,H,H,F,CF 2HCH2], [RC97;H,F,H,F,Me], [RC98;H,F,H,F,Et], [RC99;H,F,H,F,Pr], [RC100;H,F,H,F,i-Pr], [RC101;H,F,H,F,c-Pr], [RC102;H,F,H,F,Bu], [RC103;H,F,H,F,i-Bu],

[RC104;H,F,H,F,t-Bu], [RC105;H,F,H,F,c-PrCH 2], [RC106;H,F,H,F,Ph],

[RC107;H,F,H,F,Bn], [RC108;H,F,H,F,CF 3], [RC109;H,F,H,F,CF 3CH2],

[RC1 10;H,F,H,F,CF3CF2], [RC1 11;H,F,H,F,CF2H], [RC1 12;H,F,H,F,CF2HCH2] The compound represented by formula (V): [Chem.100

(wherein R2 1, R22, R23, R24, and R25 are the same as defined above) wherein R2 1, R22, R23, R24, and R25 represent any one combination indicated in the following substituent numbers RD1 to RD1 12 (hereinafter the compounds of sub stituent numbers RD1 to RD1 12 are referred to as "Present compounds RD1 to RD1 12", and the "Present compounds RD1 to RD1 12" are collectively referred to as "Present compound RD") can be prepared according to the method described in the above processes. The substituent numbers RD1 to RD1 12 as described herein represent the com binations of R2 1, R22, R23, R24 , and R25 in the compound represented by formula (V), and hereinafter are indicated by [substituent number;R 2 1,R22,R2 ,R24,R25]. For example, the substituent number RD4 represents the combination wherein R2 1, R22, R23, and R24 are each a hydrogen atom, and R25 is an isopropyl group. For example, the Present compound RD4 indicates the compound represented by formula (V) wherein the substituent number is RD4, and indicates the compound rep resented by formula (V) wherein R2 1, R22, R23, and R24 are each a hydrogen atom, and R 2 is an isopropyl group as shown in the following. [Chem.101]

[Substituent number;R ,R ,R ,R ,R25]: [RD 1;H,H,H,H,Me] , [RD2;H,H,H,H,Et], [RD3;H,H,H,H,Pr], [RD4;H,H,H,H,i-Pr], [RD5;H,H,H,H,c-Pr], [RD6;H,H,H,H,Bu],

[RD7;H,H,H,H,i-Bu], [RD8;H,H,H,H,t-Bu], [RD9;H,H,H,H,c-PrCH 2],

[RD10;H,H,H,H,Ph], [RD 11;H,H,H,H,Bn] , [RD12;H,H,H,H,CF 3],

[RD 13;H,H,H,H,CF 3CH2], [RD 14;H,H,H,H,CF 3CF2], [RD 15;H,H,H,H,CF 2H],

[RD16;H,H,H,H,CF 2HCH 2], [RD 17;F,H,H,H,Me] , [RD 18;F,H,H,H,Et] , [RD19;F,H,H,H,Pr], [RD20;F,H,H,H,i-Pr], [RD21;F,H,H,H,c-Pr], [RD22;F,H,H,H,Bu], [RD23;F,H,H,H,i-Bu], [RD24;F,H,H,H,t-Bu],

[RD25;F,H,H,H,c-PrCH 2], [RD26;F,H,H,H,Ph], [RD27 ;F,H,H,H,Bn] ,

[RD28 ;F,H,H,H,CF 3], [RD29;F,H,H,H,CF 3CH2], [RD30;F,H,H,H,CF 3CF2],

[RD31;F,H,H,H,CF 2H], [RD32;F,H,H,H,CF 2HCH 2], [RD33;H,F,H,H,Me], [RD34;H,F,H,H,Et], [RD35;H,F,H,H,Pr], [RD36;H,F,H,H,i-Pr], [RD37;H,F,H,H,c-Pr], [RD38;H,F,H,H,Bu], [RD39;H,F,H,H,i-Bu], [RD40;H,F,H,H,t-Bu],

[RD41;H,F,H,H,c-PrCH 2], [RD42;H,F,H,H,Ph], [RD43 ;H,F,H,H,Bn] ,

[RD44;H,F,H,H,CF 3], [RD45 ;H,F,H,H,CF 3CH2], [RD46 ;H,F,H,H,CF 3CF2],

[RD47;H,F,H,H,CF 2H], [RD48;H,F,H,H,CF 2HCH 2], [RD49;F,F,H,H,Me], [RD50;F,F,H,H,Et] , [RD51;F,F,H,H,Pr], [RD52;F,F,H,H,i-Pr], [RD53;F,F,H,H,c-Pr], [RD54;F,F,H,H,Bu], [RD55;F,F,H,H,i-Bu], [RD56;F,F,H,H,t-Bu],

[RD57;F,F,H,H,c-PrCH 2], [RD58;F,F,H,H,Ph], [RD59;F,F,H,H,Bn],

[RD60;F,F,H,H,CF 3], [RD6 1;F,F,H,H,CF 3CH2], [RD62;F,F,H,H,CF 3CF2],

[RD63;F,F,H,H,CF 2H], [RD64;F,F,H,H,CF 2HCH 2], [RD65 ;F,H,F,H,Me] , [RD66;F,H,F,H,Et], [RD67;F,H,F,H,Pr], [RD68;F,H,F,H,i-Pr], [RD69;F,H,F,H,c-Pr], [RD70;F,H,F,H,Bu], [RD71;F,H,F,H,i-Bu], [RD72;F,H,F,H,t-Bu],

[RD73;F,H,F,H,c-PrCH 2], [RD74;F,H,F,H,Ph], [RD75;F,H,F,H,Bn],

[RD76;F,H,F,H,CF 3], [RD77;F,H,F,H,CF 3CH2], [RD78;F,H,F,H,CF 3CF2],

[RD79;F,H,F,H,CF 2H], [RD80;F,H,F,H,CF 2HCH 2], [RD8 1;F,H,H,F,Me] , [RD82;F,H,H,F,Et] , [RD83;F,H,H,F,Pr], [RD84;F,H,H,F,i-Pr], [RD85;F,H,H,F,c-Pr], [RD86;F,H,H,F,Bu], [RD87;F,H,H,F,i-Bu], [RD88;F,H,H,F,t-Bu],

[RD89;F,H,H,F,c-PrCH 2], [RD90;F,H,H,F,Ph], [RD9 1;F,H,H,F,Bn] ,

[RD92;F,H,H,F,CF 3], [RD93 ;F,H,H,F,CF 3CH2], [RD94;F,H,H,F,CF 3CF2],

[RD95;F,H,H,F,CF 2H], [RD96;F,H,H,F,CF 2HCH 2], [RD97 ;H,F,H,F,Me] , [RD98;H,F,H,F,Et], [RD99;H,F,H,F,Pr], [RD100;H,F,H,F,i-Pr], [RD101;H,F,H,F,c-Pr], [RD102;H,F,H,F,Bu], [RD103;H,F,H,F,i-Bu],

[RD104;H,F,H,F,t-Bu], [RD105;H,F,H,F,c-PrCH 2], [RD106;H,F,H,F,Ph],

[RD107;H,F,H,F,Bn] , [RD 108 ;H,F,H,F,CF 3], [RD 109;H,F,H,F,CF 3CH2],

[RD1 10;H,F,H,F,CF 3CF2], [RD 111 ;H,F,H,F,CF 2H], [RD1 12;H,F,H,F,CF 2HCH 2] The compound represented by formula (VI): [Chem.102]

(wherein R2 1, R22, R23, R24, and R25 are the same as defined above) wherein R2 1, R22, R23, R24 , and R25 represent any one combination indicated in the following substituent numbers REl to REl 12 (hereinafter the compounds of the substituent numbers REl to REl 12 are referred to as "Present compounds REl to REl 12", and the "Present compounds REl to REl 12" are collectively referred to as "Present compound RE") can be prepared according to the method described in the above processes. The substituent numbers REl to REl 12 as described herein represent the com binations of R2 1, R22, R23, R24 , and R25 in the compound represented by formula (VI), and hereinafter are indicated by [substituent number;R 2 1,R22,R2 ,R24,R25]. For example, the substituent number RE4 represents the combination wherein R2 1, R22, R23, and R24 are each a hydrogen atom, and R25 is an isopropyl group. For example, the Present compound RE4 indicates the compound represented by formula (VI) wherein the substituent number is RE4, and indicates the compound rep resented by formula (VI) wherein R2 1, R22, R23, and R24 are each a hydrogen atom, and R25 is an isopropyl group as shown in the following. [Chem.103]

[Substituent number;R ,R ,R ,R ,R25]: [RE 1;H,H,H,H,Me] , [RE2;H,H,H,H,Et], [RE3;H,H,H,H,Pr], [RE4;H,H,H,H,i-Pr], [RE5;H,H,H,H,c-Pr], [RE6;H,H,H,H,Bu],

[RE7;H,H,H,H,i-Bu], [RE8;H,H,H,H,t-Bu], [RE9;H,H,H,H,c-PrCH 2],

[RE10;H,H,H,H,Ph], [RE 11;H,H,H,H,Bn] , [RE12;H,H,H,H,CF 3], [RE13;H,H,H,H,CF 3

CH2], [RE14;H,H,H,H,CF 3CF2], [RE15;H,H,H,H,CF 2H], [RE16;H,H,H,H,CF 2HCH 2], [RE 17;F,H,H,H,Me] , [RE1 8;F,H,H,H,Et] , [RE19;F,H,H,H,Pr], [RE20;F,H,H,H,i-Pr], [RE21;F,H,H,H,c-Pr], [RE22;F,H,H,H,Bu], [RE23;F,H,H,H,i-Bu],

[RE24;F,H,H,H,t-Bu], [RE25;F,H,H,H,c-PrCH 2], [RE26;F,H,H,H,Ph],

[RE27 ;F,H,H,H,Bn] , [RE28;F,H,H,H,CF 3], [RE29;F,H,H,H,CF 3CH2],

[RE30;F,H,H,H,CF 3CF2], [RE31;F,H,H,H,CF 2H], [RE32;F,H,H,H,CF 2HCH 2], [RE33;H,F,H,H,Me], [RE34;H,F,H,H,Et], [RE35;H,F,H,H,Pr], [RE36;H,F,H,H,i-Pr], [RE37;H,F,H,H,c-Pr], [RE38;H,F,H,H,Bu], [RE39;H,F,H,H,i-Bu],

[RE40;H,F,H,H,t-Bu], [RE41;H,F,H,H,c-PrCH 2], [RE42;H,F,H,H,Ph],

[RE43 ;H,F,H,H,Bn] , [RE44;H,F,H,H,CF 3], [RE45;H,F,H,H,CF 3CH2],

[RE46;H,F,H,H,CF 3CF2], [RE47 ;H,F,H,H,CF 2H], [RE48 ;H,F,H,H,CF 2HCH 2], [RE49;F,F,H,H,Me], [RE50;F,F,H,H,Et] , [RE51;F,F,H,H,Pr], [RE52;F,F,H,H,i-Pr], [RE53;F,F,H,H,c-Pr], [RE54;F,F,H,H,Bu], [RE55;F,F,H,H,i-Bu],

[RE56;F,F,H,H,t-Bu], [RE57;F,F,H,H,c-PrCH 2], [RE58;F,F,H,H,Ph],

[RE59;F,F,H,H,Bn], [RE60;F,F,H,H,CF 3], [RE61;F,F,H,H,CF 3CH2],

[RE62;F,F,H,H,CF 3CF2], [RE63 ;F,F,H,H,CF 2H], [RE64;F,F,H,H,CF 2HCH 2], [RE65 ;F,H,F,H,Me] , [RE66;F,H,F,H,Et], [RE67;F,H,F,H,Pr], [RE68;F,H,F,H,i-Pr], [RE69;F,H,F,H,c-Pr], [RE70;F,H,F,H,Bu], [RE71;F,H,F,H,i-Bu],

[RE72;F,H,F,H,t-Bu], [RE73;F,H,F,H,c-PrCH 2], [RE74;F,H,F,H,Ph],

[RE75;F,H,F,H,Bn], [RE76;F,H,F,H,CF 3], [RE77;F,H,F,H,CF 3CH2],

[RE78;F,H,F,H,CF 3CF2], [RE79 ;F,H,F,H,CF 2H], [RE80;F,H,F,H,CF 2HCH 2], [RE8 1;F,H,H,F,Me] , [RE82;F,H,H,F,Et], [RE83;F,H,H,F,Pr], [RE84;F,H,H,F,i-Pr], [RE85;F,H,H,F,c-Pr], [RE86;F,H,H,F,Bu], [RE87;F,H,H,F,i-Bu],

[RE88;F,H,H,F,t-Bu], [RE89;F,H,H,F,c-PrCH 2], [RE90;F,H,H,F,Ph],

[RE91;F,H,H,F,Bn], [RE92;F,H,H,F,CF 3], [RE93;F,H,H,F,CF 3CH2],

[RE94;F,H,H,F,CF 3CF2], [RE95 ;F,H,H,F,CF 2H], [RE96;F,H,H,F,CF 2HCH 2], [RE97 ;H,F,H,F,Me] , [RE98 ;H,F,H,F,Et] , [RE99;H,F,H,F,Pr], [RE100;H,F,H,F,i-Pr], [RE101;H,F,H,F,c-Pr], [RE102;H,F,H,F,Bu], [RE103;H,F,H,F,i-Bu],

[RE104;H,F,H,F,t-Bu], [RE105;H,F,H,F,c-PrCH 2], [RE106;H,F,H,F,Ph],

[RE 107;H,F,H,F,Bn] , [RE 108;H,F,H,F,CF 3], [RE 109;H,F,H,F,CF 3CH2],

[RE1 10;H,F,H,F,CF 3CF2], [RE1 11;H,F,H,F,CF 2H], [RE1 12;H,F,H,F,CF 2HCH 2] The compound represented by formula (VII): [Chem.104]

(wherein R2 1, R22, R23, R24, and R25 are the same as defined above) wherein R2 1, R22, R23, R24 , and R25 represent any one combination indicated in the following substituent numbers RFl to RFl 12 (hereinafter the compounds of the sub stituent numbers RFl to RFl 12 are referred to as "Present compounds RFl to RFl 12", and the "Present compounds RFl to RFl 12" are collectively referred to as "Present compound RF") can be prepared according to the method described in the above processes. The substituent numbers RFl to RFl 12 as described herein represent the com binations of R2 1, R22, R23, R24 , and R25 in the compound represented by formula (VII), and hereinafter are indicated by [substituent number;R 2 1,R22,R2 ,R24,R25]. For example, the substituent number RF4 represents the combination wherein R2 1, R 22, R23, and R24 are each a hydrogen atom, and R25 is an isopropyl group. For example, the Present compound RF4 indicates the compound represented by formula (VII) wherein the substituent number is RF4, and indicates the compound rep resented by formula (VII) wherein R2 1, R22, R23, and R24 are each a hydrogen atom, and R25 is an isopropyl group as shown in the following. [Chem.105]

[Substituent number;R 2 1,R22,R2 ,R24,R25]: [RF1;H,H,H,H,Me], [RF2;H,H,H,H,Et] , [RF3;H,H,H,H,Pr], [RF4;H,H,H,H,i-Pr], [RF5;H,H,H,H,c-Pr], [RF6;H,H,H,H,Bu],

[RF7;H,H,H,H,i-Bu], [RF8;H,H,H,H,t-Bu], [RF9;H,H,H,H,c-PrCH 2],

[RF10;H,H,H,H,Ph], [RF11;H,H,H,H,Bn] , [RF12;H,H,H,H,CF 3], [RF13;H,H,H,H,CF 3

CH2], [RF14;H,H,H,H,CF 3CF2], [RF15;H,H,H,H,CF 2H], [RF16;H,H,H,H,CF 2HCH2], [RF17;F,H,H,H,Me], [RF18;F,H,H,H,Et], [RF19;F,H,H,H,Pr], [RF20;F,H,H,H,i-Pr], [RF21;F,H,H,H,c-Pr], [RF22;F,H,H,H,Bu], [RF23;F,H,H,H,i-Bu],

[RF24;F,H,H,H,t-Bu], [RF25;F,H,H,H,c-PrCH 2], [RF26;F,H,H,H,Ph],

[RF27;F,H,H,H,Bn], [RF28;F,H,H,H,CF 3], [RF29;F,H,H,H,CF 3CH2],

[RF30;F,H,H,H,CF 3CF2], [RF3 1;F,H,H,H,CF2H], [RF32;F,H,H,H,CF 2HCH2], [RF33;H,F,H,H,Me], [RF34;H,F,H,H,Et], [RF35;H,F,H,H,Pr], [RF36;H,F,H,H,i-Pr], [RF37;H,F,H,H,c-Pr], [RF38;H,F,H,H,Bu], [RF39;H,F,H,H,i-Bu],

[RF40;H,F,H,H,t-Bu], [RF41;H,F,H,H,c-PrCH 2], [RF42;H,F,H,H,Ph],

[RF43;H,F,H,H,Bn], [RF44;H,F,H,H,CF 3], [RF45;H,F,H,H,CF 3CH2],

[RF46;H,F,H,H,CF3CF2], [RF47;H,F,H,H,CF2H], [RF48;H,F,H,H,CF2HCH2], [RF49;F,F,H,H,Me], [RF50;F,F,H,H,Et] , [RF51;F,F,H,H,Pr], [RF52;F,F,H,H,i-Pr], [RF53;F,F,H,H,c-Pr], [RF54;F,F,H,H,Bu], [RF55;F,F,H,H,i-Bu],

[RF56;F,F,H,H,t-Bu], [RF57;F,F,H,H,c-PrCH 2], [RF58;F,F,H,H,Ph],

[RF59;F,F,H,H,Bn], [RF60;F,F,H,H,CF 3], [RF61;F,F,H,H,CF 3CH2],

[RF62;F,F,H,H,CF 3CF2], [RF63;F,F,H,H,CF2H], [RF64;F,F,H,H,CF 2HCH2], [RF65;F,H,F,H,Me], [RF66;F,H,F,H,Et], [RF67;F,H,F,H,Pr], [RF68;F,H,F,H,i-Pr], [RF69;F,H,F,H,c-Pr], [RF70;F,H,F,H,Bu], [RF71;F,H,F,H,i-Bu],

[RF72;F,H,F,H,t-Bu], [RF73;F,H,F,H,c-PrCH 2], [RF74;F,H,F,H,Ph],

[RF75;F,H,F,H,Bn], [RF76;F,H,F,H,CF 3], [RF77;F,H,F,H,CF 3CH2],

[RF78;F,H,F,H,CF 3CF2], [RF79;F,H,F,H,CF 2H], [RF80;F,H,F,H,CF 2HCH2], [RF8 1;F,H,H,F,Me], [RF82;F,H,H,F,Et] , [RF83;F,H,H,F,Pr], [RF84;F,H,H,F,i-Pr], [RF85;F,H,H,F,c-Pr], [RF86;F,H,H,F,Bu], [RF87;F,H,H,F,i-Bu],

[RF88;F,H,H,F,t-Bu], [RF89;F,H,H,F,c-PrCH 2], [RF90;F,H,H,F,Ph],

[RF9 1;F,H,H,F,Bn], [RF92;F,H,H,F,CF 3], [RF93;F,H,H,F,CF 3CH2],

[RF94;F,H,H,F,CF 3CF ], [RF95;F,H,H,F,CF H], [RF96;F,H,H,F,CF HCH ], [RF97;H,F,H,F,Me], [RF98;H,F,H,F,Et], [RF99;H,F,H,F,Pr], [RF100;H,F,H,F,i-Pr], [RF101;H,F,H,F,c-Pr], [RF102;H,F,H,F,Bu], [RF103;H,F,H,F,i-Bu],

[RF104;H,F,H,F,t-Bu], [RF105;H,F,H,F,c-PrCH 2], [RF106;H,F,H,F,Ph],

[RF107;H,F,H,F,Bn], [RF108;H,F,H,F,CF 3], [RF109;H,F,H,F,CF 3CH2],

[RF1 10;H,F,H,F,CF 3CF2], [RF1 11;H,F,H,F,CF 2H], [RF1 12;H,F,H,F,CF 2HCH 2] The compound represented by formula (VIII): Chem.106]

(wherein R25 is the same as defined above; and Q2 1 is an oxygen atom or a NR7) wherein Q2 1 and R25 represent any one combination indicated in the following sub stituent numbers RGl to RG30 (hereinafter the compounds of the substituent numbers RGl to RG30 are referred to as "Present compounds RGl to RG30", and the "Present compounds RGl to RG30" are collectively referred to as "Present compound RG") can be prepared according to the method described in the above processes. The substituent numbers RGl to RG30 as described herein represent the com binations of Q2 1 and R25 in the compound represented by formula (VIII), and hereinafter are indicated by [substituent number;Q 2 1,R25]. For example, the substituent number RG4 represents the combination wherein Q2 1 is an oxygen atom, and R25 is an isopropyl group. For example, the Present compound RG4 indicates the compound represented by formula (VIII) wherein the substituent number is RG4, and indicates the compound represented by formula (VIII) wherein Q2 1 is an oxygen atom, and R25 is an isopropyl group as shown in the following. [Chem.107]

[Substituent number;Q ,R25]: [RGl;0,Me], [RG2;0,Et], [RG3;0,Pr], [RG4;0,i-Pr],

[RG5;0,c-Pr], [RG6;0,Bu], [RG7;0,t-Bu], [RG8;0,c-PrCH 2], [RG9;0,Ph],

[RG10;O,Bn], [RG11;0,CF 3], [RG12;0,CF 3CH2], [RG13;0,CF 3CF2], [RG14;0,CF 2H], [RG15;0,CF 2HCH 2], [RG16;NH,Me], [RG17;NH,Et], [RG18;NH,Pr], [RG19;NH,i-Pr], [RG20;NH,c-Pr], [RG21;NH,Bu], [RG22;NH,t-Bu],

[RG23;NH,c-PrCH 2], [RG24;NH,Ph], [RG25;NH,Bn], [RG26;NH,CF 3],

[RG27;NH,CF 3CH2], [RG28;NH,CF 3CF2], [RG29;NH,CF 2H], [RG30;NH,CF 2HCH 2] The compound represented by formula (IX) : [Chem.108]

(wherein R25 is the same as defined above; and

26 7 7 7 R is a N0 2, a C(0)R , a C(0)OR , or a S(0) 2R ) wherein R25 and R26 represent any one combination indicated in the following sub stituent numbers RH1 to RH54 (hereinafter the compounds of the substituent numbers RH1 to RH54 are referred to as "Present compounds RH1 to RH54", and the "Present compounds RH1 to RH54" are collectively referred to as "Present compound RH") can be prepared according to the method described in the above processes. The substituent numbers RH1 to RH54 as described herein represent the com binations of R25 and R26 in the compound represented by formula (IX), and hereinafter are indicated by [substituent number;R 25,R26]. For example, the substituent number RH4 represents the combination wherein R25 is a cyclopropyl group, and R26 is a C(0)Me. For example, the Present compound RH4 indicates the compound represented by formula (IX) wherein the substituent number is RH4, and indicates the compound rep resented by formula (IX) wherein R25 is a cyclopropyl group, and R26 is a C(0)Me as shown in the following. [Chem.109]

[Substituent number;R ,R26]: [RHl;Me,C(0)Me], [RH2;Et,C(0)Me],

[RH3;i-Pr,C(0)Me], [RH4;c-Pr,C(0)Me], [RH5;CF 2H,C(0)Me], [RH6;CF 3,C(0)Me], [RH7;Me,C(0)Et], [RH8;Et,C(0)Et], [RH9;i-Pr,C(0)Et], [RH10;c-Pr,C(O)Et], [RHll;CF 2H,C(0)Et], [RH12;CF 3,C(0)Et], [RH13;Me,C(0)CF 3], [RH14;Et,C(0)CF 3

], [RH15;i-Pr,C(0)CF 3], [RH16;c-Pr,C(0)CF 3], [RH17;CF 2H,C(0)CF 3], [RH18;CF 3

,C(0)CF 3], [RH19;Me,C(0)OMe], [RH20;Et,C(O)OMe], [RH21;i-Pr,C(0)OMe],

[RH22;c-Pr,C(0)OMe], [RH23;CF 2H,C(0)OMe], [RH24;CF 3,C(0)OMe], [RH25;Me,C(0)OEt], [RH26;Et,C(0)OEt], [RH27;i-Pr,C(0)OEt],

[RH28;c-Pr,C(0)OEt], [RH29;CF 2H,C(0)OEt], [RH30;CF 3,C(O)OEt],

[RH31;Me,S(0) 2Me], [RH32;Et,S(0) 2Me], [RH33;i-Pr,S(0) 2Me], [RH34;c-Pr,S(0) 2

Me], [RH35;CF 2H,S(0) 2Me], [RH36;CF 3,S(0) 2Me], [RH37;Me,S(0) 2Et],

[RH38;Et,S(0) 2Et], [RH39;i-Pr,S(0) 2Et], [RH40;c-Pr,S(O) 2Et], [RH41;CF 2H,S(0) 2Et],

[RH42;CF 3,S(0) 2Et], [RH43;Me,S(0) 2CF3], [RH44;Et,S(0) 2CF3], [RH45;i-Pr,S(0) 2CF

3], [RH46;c-Pr,S(0) CF3], [RH47;CF H,S(0) CF3], [RH48;CF 3,S(0) CF3],

[RH49;Me,C(0)CF 2H], [RH50;Et,C(O)CF 2H], [RH51;i-Pr,C(0)CF 2H],

[RH52;c-Pr,C(0)CF 2H], [RH53;CF 2H,C(0)CF 2H], [RH54;CF 3,C(0)CF 2H] The compound represented by formula (X): [Chem.110]

(wherein R25 and Q2 1 are the same as defined above) wherein Q2 1 and R25 represent any one combination indicated in the following sub stituent numbers RI1 to RI30 (hereinafter the compounds of the substituent numbers RI1 to RI30 are referred to as "Present compounds RI1 to RI30", and the "Present compounds RI1 to RI30" are collectively referred to as "Present compound RI") can be prepared according to the method described in the above processes. The substituent numbers RI1 to RI30 as described herein represent the combinations of Q2 1 and R25 in the compound represented by formula (X), and hereinafter are indicated by [substituent number;Q 2 1,R25]. For example, the substituent number RI4 represents the combination wherein Q2 1 is an oxygen atom, and R25 is an isopropyl group. For example, the Present compound RI4 indicates the compound represented by formula (X) wherein the substituent number is RI4, and indicates the compound rep resented by formula (X) wherein Q2 1 is an oxygen atom, and R25 is an isopropyl group as shown in the following. [Chem.lll]

[0176] [Substituent number;Q ,R25]: [RIl;0,Me], [RI2;0,Et], [RI3;0,Pr], [RI4;0,i-Pr],

[RI5;0,c-Pr], [RI6;0,Bu], [RI7;0,t-Bu], [RI8;0,c-PrCH 2], [RI9;0,Ph], [RI10;O,Bn],

[RI11;0,CF 3], [RI12;0,CF 3CH2], [RI13;0,CF 3CF2], [RI14;0,CF 2H], [RI15;0,CF 2HCH

2], [RI16;NH,Me], [RI17;NH,Et], [RI18;NH,Pr], [RI19;NH,i-Pr], [RI20;NH,c-Pr],

[RI21;NH,Bu], [RI22;NH,t-Bu], [RI23;NH,c-PrCH 2], [RI24;NH,Ph], [RI25;NH,Bn],

[RI26;NH,CF 3], [RI27;NH,CF 3CH2], [RI28;NH,CF 3CF2], [RI29;NH,CF 2H],

[RI30;NH,CF 2HCH 2] [0177] The compound represented by formula (XI): [Chem.112]

(wherein R25 and Q2 1 are the same as defined above.) wherein Q2 1 and R25 represent any one combination indicated in the following sub stituent numbers RJl to RJ30 (hereinafter the compounds of the substituent numbers RJl to RJ30 are referred to as "Present compounds RJl to RJ30", and the "Present compounds RJl to RJ30" are collectively referred to as "Present compound RJ") can be prepared according to the method described in the above processes. The substituent numbers RJl to RJ30 as described herein represent the combinations of Q2 1 and R25 in the compound represented by formula (XI), and hereinafter are indicated by [substituent number;Q 2 1,R25]. For example, the substituent number RJ4 represents the combination wherein Q2 1 is an oxygen atom, and R25 is an isopropyl group. For example, the Present compound RJ4 indicates the compound represented by formula (XI) wherein the substituent number is RJ4, and indicates the compound rep resented by formula (XI) wherein Q2 1 is an oxygen atom, and R25 is an isopropyl group as shown in the following. [Chem.113

[0179] [Substituent number;Q ,R25]: [RJl;0,Me], [RJ2;0,Et], [RJ3;0,Pr], [RJ4;0,i-Pr],

[RJ5;0,c-Pr], [RJ6;0,Bu], [RJ7;0,t-Bu], [RJ8;0,c-PrCH 2], [RJ9;0,Ph], [RJ10;O,Bn],

[RJ11;0,CF 3], [RJ12;0,CF 3CH2], [RJ13;0,CF 3CF2], [RJ14;0,CF 2H], [RJ15;0,CF 2

HCH 2], [RJ16;NH,Me], [RJ17;NH,Et], [RJ18;NH,Pr], [RJ19;NH,i-Pr],

[RJ20;NH,c-Pr], [RJ21;NH,Bu], [RJ22;NH,t-Bu], [RJ23;NH,c-PrCH 2], [RJ24;NH,Ph],

[RJ25;NH,Bn], [RJ26;NH,CF 3], [RJ27;NH,CF 3CH2], [RJ28;NH,CF 3CF2],

[RJ29;NH,CF 2H], [RJ30;NH,CF 2HCH 2] [0180] The compound represented by formula (XII): [Chem.114]

(wherein R25 is the same as defined above; and R3 1 is a hydrogen atom, a C1-C6 alkyl group optionally having one or more substituents selected from Group A, a C3-C6 alkynyl group optionally having one or more halogen atoms, a C1-C6 alkoxy group optionally having one or more halogen atoms, a C3-C6 cycloalkyl group optionally having one or more substituents selected from Group D, or a phenyl group optionally having one or more substituents selected from Group D, or R25 and R3 1 may be combined with each other to form a 5 to 7 membered heterocyclic group (wherein said 5 to 7 membered heterocyclic group may optionally have one or more substituents selected from Group D)) wherein R3 1 and R25 represent any one combination indicated in the following sub stituent numbers RK1 to RK407 (hereinafter the compounds of the substituent numbers RK1 to RK407 are referred to as "Present compounds RK1 to RK407", and the "Present compounds RK1 to RK407" are collectively referred to as "Present compound RK") can be prepared according to the method described in the above processes. The substituent numbers RK1 to RK407 as described herein represent the com binations of R3 1 and R25 in the compound represented by formula (XII), and hereinafter are indicated by [substituent number ;R 1,R25], except that the substituent numbers RK166 and RK167 represent that R3 1 and R25 are combined with each other to form a heterocyclic group. For example, the substituent number RK4 represents the combination wherein R3 1 is a hydrogen atom, and R25 is an isopropyl group. [0181] The 5 to 7 membered heterocyclic group formed by combining R25 and R3 1 with each other represents any one structure of the followings (ZF1 1 to ZF13) (wherein the symbol "·" represents the point of attachment). [Chem.115]

(ZF11) (ZF12) (ZF13) For example, the Present compound RK4 indicates the compound represented by formula (XII) wherein the substituent number is RK4, and indicates the compound rep resented by formula (XII) wherein R3 1 is a hydrogen atom, and R25 is an isopropyl group as shown in the following. [Chem.116]

[0183] [Substituent number;R 1,R25]: [RKl;H,Me], [RK2;H,Et], [RK3;H,Pr], [RK4;H,i-Pr],

[RK5;H,c-Pr], [RK6;H,Bu], [RK7;H,t-Bu], [RK8;H,c-PrCH 2], [RK9;H,Ph],

[RK10;H,Bn], [RK11;H,CF 3], [RK12;H,CF 3CH2], [RK13;H,CF 3CF2], [RK14;H,CF 2H],

[RK15;H,CF 2HCH 2], [RK16;Me,Me], [RK17;Me,Et], [RK18;Me,Pr], [RK19;Me,i-Pr],

[RK20;Me,c-Pr], [RK21Me,Bu], [RK22;Me,t-Bu], [RK23;Me,c-PrCH 2],

[RK24;Me,Ph], [RK25;Me,Bn], [RK26;Me,CF 3], [RK27;Me,CF 3CH2], [RK28;Me,CF 3

CF2], [RK29;Me,CF 2H], [RK30;Me,CF 2HCH 2], [RK31;Et,Me], [RK32;Et,Et], [RK33;Et,Pr], [RK34;Et,i-Pr], [RK35;Et,c-Pr], [RK36;Et,Bu], [RK37;Et,t-Bu],

[RK38;Et,c-PrCH 2], [RK39;Et,Ph], [RK40;Et,Bn], [RK41;Et,CF 3], [RK42;Et,CF 3CH2],

[RK43;Et,CF 3CF2], [RK44;Et,CF 2H], [RK45;Et,CF 2HCH 2], [RK46;Pr,Me], [RK47;Pr,Et], [RK48;Pr,Pr], [RK49;Pr,i-Pr], [RK50;Pr,c-Pr], [RK51;Pr,Bu],

[RK52;Pr,t-Bu], [RK53;Pr,c-PrCH 2], [RK54;Pr,Ph], [RK55;Pr,Bn], [RK56;Pr,CF 3],

[RK57;Pr,CF 3CH2], [RK58;Pr,CF 3CF2], [RK59;Pr,CF 2H], [RK60;Pr,CF 2HCH 2], [RK61;i-Pr,Me], [RK62;i-Pr,Et], [RK63;i-Pr,Pr], [RK64;i-Pr,i-Pr], [RK65;i-Pr,c-Pr],

[RK66;i-Pr,Bu], [RK67;i-Pr,t-Bu], [RK68;i-Pr,c-PrCH 2], [RK69;i-Pr,Ph], [RK70;i-Pr,Bn], [RK71;i-Pr,CF3], [RK72;i-Pr,CF3CH2], [RK73;i-Pr,CF3CF2],

[RK74;i-Pr,CF2H], [RK75;i-Pr,CF2HCH2], [RK76;c-Pr,Me], [RK77;c-Pr,Et], [RK78;c-Pr,Pr], [RK79;c-Pr,i-Pr], [RK80;c-Pr,c-Pr], [RK81;c-Pr,Bu],

[RK82;c-Pr,t-Bu], [RK83;c-Pr,c-PrCH2], [RK84;c-Pr,Ph], [RK85;c-Pr,Bn],

[RK86;c-Pr,CF3], [RK87;c-Pr,CF3CH2], [RK88;c-Pr,CF3CF2], [RK89;c-Pr,CF2H],

[RK90;c-Pr,CF2HCH2], [RK91;c-PrCH2,Me], [RK92;c-PrCH2,Et], [RK93;c-PrCH2,Pr],

[RK94;c-PrCH2,i-Pr], [RK95;c-PrCH2,c-Pr], [RK96;c-PrCH2,Bu], [RK97;c-PrCH2

,t-Bu], [RK98;c-PrCH2,c-PrCH2], [RK99;c-PrCH2,Ph], [RK100;c-PrCH2,Bn],

[RK101;c-PrCH2,CF3], [RK102;c-PrCH2,CF3CH2], [RK103;c-PrCH2,CF3CF2],

[RK104;c-PrCH2,CF2H], [RK105;c-PrCH2,CF2HCH2], [RK106;CF3CH2,Me],

[RK107;CF3CH2,Et], [RK108;CF3CH2,Pr], [RK109;CF3CH2,i-Pr], [RK110;CF3CH2

,c-Pr], [RKlll;CF 3CH2,Bu], [RK112;CF3CH2,t-Bu], [RK113;CF3CH2,c-PrCH2],

[RK114;CF3CH2,Ph], [RK115;CF3CH2,Bn], [RK116;CF3CH2,CF3], [RK117;CF3CH2

,CF3CH2], [RK118;CF3CH2,CF3CF2], [RK119;CF3CH2,CF2H], [RK120;CF3CH2,CF2

HCH2], [RK121;CF2HCH2,Me], [RK122;CF2HCH2,Et], [RK123;CF2HCH2,Pr],

[RK124;CF2HCH2,i-Pr], [RK125;CF2HCH2,c-Pr], [RK126;CF2HCH2,Bu], [RK127;CF2

HCH2,t-Bu], [RK128;CF2HCH2,c-PrCH2], [RK129;CF2HCH2,Ph], [RK130;CF2HCH2

,Bn], [RK131;CF2HCH2,CF3], [RK132;CF2HCH2,CF3CH2], [RK133;CF2HCH2,CF3CF2

], [RK134;CF2HCH2,CF2H], [RK135;CF2HCH2,CF2HCH2], [RK136;MeOCH2,Me],

[RK137;MeOCH2,Et], [RK138;MeOCH2,Pr], [RK139;MeOCH2,i-Pr],

[RK140;MeOCH2,c-Pr], [RK141;MeOCH2,Bu], [RK142;MeOCH2,t-Bu],

[RK143;MeOCH2,c-PrCH2], [RK144;MeOCH2,Ph], [RK145;MeOCH2,Bn],

[RK146;MeOCH2,CF3], [RK147;MeOCH2,CF3CH2], [RK148;MeOCH2,CF3CF2],

[RK149;MeOCH2,CF2H], [RK150;MeOCH2,CF2HCH2], [RK151;EtOCH2,Me],

[RK152;EtOCH2,Et], [RK153;EtOCH2,Pr], [RK154;EtOCH2,i-Pr], [RK155;EtOCH2

,c-Pr], [RK156;EtOCH2,Bu], [RK157;EtOCH2,t-Bu], [RK158;EtOCH2,c-PrCH2],

[RK159;EtOCH2,Ph], [RK160;EtOCH2,Bn], [RK161;EtOCH2,CF3], [RK162;EtOCH2

,CF3CH2], [RK163;EtOCH2,CF3CF2], [RK164;EtOCH2,CF2H], [RK165;EtOCH2,CF2

HCH2], [RK166;CH2CH2CH2], [RK167;CH2CH2CH2CH2], [RK168;t-Bu,Me], [RK169;t-Bu,Et], [RK170;t-Bu,Pr], [RK171;t-Bu,i-Pr], [RK172;t-Bu,c-Pr],

[RK173;t-Bu,t-Bu], [RK174;t-Bu,Bu], [RK175;t-Bu,t-Bu], [RK176;t-Bu,c-PrCH 2],

[RK177;t-Bu,Ph], [RK178;t-Bu,Bn], [RK179;t-Bu,CF3], [RK180;t-Bu,CF3CH2],

[RK181;t-Bu,CF3CF2], [RK182;t-Bu,CF2H], [RK183;t-Bu,CF2HCH2], [RK184;i-Bu,Me], [RK185;i-Bu,Et], [RK186;i-Bu,Pr], [RK187;i-Bu,i-Pr], [RK188;i-Bu,c-Pr], [RK189;i-Bu,t-Bu], [RK190;i-Bu,Bu], [RK191;i-Bu,t-Bu],

[RK192;i-Bu,c-PrCH 2], [RK193;i-Bu,Ph], [RK194;i-Bu,Bn], [RK195;i-Bu,CF3],

[RK196;i-Bu,CF3CH2], [RK197;i-Bu,CF3CF2], [RK198;i-Bu,CF2H], [RK199;i-Bu,CF2

HCH2], [RK200;HCCCH2,Me], [RK201;HCCCH2,Et], [RK202;HCCCH2,Pr], [RK203;HCCCH 2,i-Pr], [RK204;HCCCH 2,c-Pr], [RK205;HCCCH 2,t-Bu],

[RK206;HCCCH 2,Bu], [RK207;HCCCH 2,t-Bu], [RK208;HCCCH 2,c-PrCH2],

[RK209;HCCCH 2,Ph], [RK210;HCCCH 2,Bn], [RK211;HCCCH 2,CF3],

[RK212;HCCCH 2,CF3CH2], [RK213;HCCCH2,CF3CF2], [RK214;HCCCH 2,CF2H],

[RK215;HCCCH 2,CF2HCH2], [RK216;MeCCCH 2,Me], [RK217;MeCCCH 2,Et],

[RK218;MeCCCH 2,Pr], [RK219;MeCCCH 2,i-Pr], [RK220;MeCCCH 2,c-Pr],

[RK221;MeCCCH 2,t-Bu], [RK222;MeCCCH 2,Bu], [RK223;MeCCCH 2,t-Bu],

[RK224;MeCCCH 2,c-PrCH2], [RK225;MeCCCH2,Ph], [RK226;MeCCCH2,Bn],

[RK227;MeCCCH2,CF3], [RK228;MeCCCH2,CF3CH2], [RK229;MeCCCH2,CF3CF2],

[RK230;MeCCCH 2,CF2H], [RK23 1;MeCCCH2,CF2HCH2], [RK232;MeSCH 2,Me],

[RK233;MeSCH 2,Et], [RK234;MeSCH 2,Pr], [RK235;MeSCH 2,i-Pr], [RK236;MeSCH 2

,c-Pr], [RK237;MeSCH 2,t-Bu], [RK238;MeSCH 2,Bu], [RK239;MeSCH 2,t-Bu],

[RK240;MeSCH 2,c-PrCH2], [RK241;MeSCH 2,Ph], [RK242;MeSCH 2,Bn],

[RK243;MeSCH2,CF3], [RK244;MeSCH 2,CF3CH2], [RK245;MeSCH2,CF3CF2],

[RK246;MeSCH 2,CF2H], [RK247;MeSCH 2,CF2HCH2], [RK248;EtSCH 2,Me],

[RK249;EtSCH 2,Et] , [RK250;EtSCH 2,Pr] ,

[RK251;EtSCH 2,i-Pr], [RK252;EtSCH 2,c-Pr], [RK253;EtSCH 2,t-Bu],

[RK254;EtSCH 2,Bu], [RK255;EtSCH 2,t-Bu], [RK256;EtSCH 2,c-PrCH2],

[RK257;EtSCH 2,Ph], [RK258;EtSCH 2,Bn], [RK259;EtSCH 2,CF3], [RK260;EtSCH 2,CF

3CH2], [RK261;EtSCH 2,CF3CF2], [RK262;EtSCH 2,CF2H], [RK263;EtSCH 2,CF2HCH2], [RK264;2-Me-Ph,Me], [RK265;2-Me-Ph,Et], [RK266;2-Me-Ph,Pr], [RK267;2-Me-Ph,i-Pr], [RK268;2-Me-Ph,c-Pr], [RK269;2-Me-Ph,t-Bu],

[RK270;2-Me-Ph,Bu], [RK271;2-Me-Ph,t-Bu], [RK272;2-Me-Ph,c-PrCH 2],

[RK273;2-Me-Ph,Ph], [RK274;2-Me-Ph,Bn], [RK275;2-Me-Ph,CF 3],

[RK276;2-Me-Ph,CF3CH2], [RK277;2-Me-Ph,CF3CF2], [RK278;2-Me-Ph,CF2H],

[RK279;2-Me-Ph,CF 2HCH2], [RK280;3-Me-Ph,Me], [RK281;3-Me-Ph,Et], [RK282;3-Me-Ph,Pr], [RK283;3-Me-Ph,i-Pr], [RK284;3-Me-Ph,c-Pr], [RK285;3-Me-Ph,t-Bu], [RK286;3-Me-Ph,Bu], [RK287;3-Me-Ph,t-Bu],

[RK288;3-Me-Ph,c-PrCH 2], [RK289;3-Me-Ph,Ph], [RK290;3-Me-Ph,Bn],

[RK291;3-Me-Ph,CF 3], [RK292;3-Me-Ph,CF 3CH2], [RK293;3-Me-Ph,CF 3CF2],

[RK294;3-Me-Ph,CF 2H], [RK295;3-Me-Ph,CF 2HCH2], [RK296;4-Me-Ph,Me], [RK297;4-Me-Ph,Et], [RK298;4-Me-Ph,Pr], [RK299;4-Me-Ph,i-Pr], [RK300;4-Me-Ph,c-Pr], [RK301;4-Me-Ph,t-Bu], [RK302;4-Me-Ph,Bu],

[RK303;4-Me-Ph,t-Bu] , [RK304;4-Me-Ph,c-PrCH 2], [RK305;4-Me-Ph,Ph] ,

[RK306;4-Me-Ph,Bn] , [RK307;4-Me-Ph,CF3], [RK308;4-Me-Ph,CF3CH2],

[RK309;4-Me-Ph,CF 3CF2], [RK310;4-Me-Ph,CF 2H], [RK31 l;4-Me-Ph,CF 2HCH2], [RK312;2-F-Ph,Me], [RK313;2-F-Ph,Et], [RK314;2-F-Ph,Pr], [RK315;2-F-Ph,i-Pr], [RK316;2-F-Ph,c-Pr], [RK317;2-F-Ph,t-Bu], [RK318;2-F-Ph,Bu], [RK319;2-F-Ph,t-Bu], [RK320;2-F-Ph,c-PrCH 2], [RK321;2-F-Ph,Ph],

[RK322;2-F-Ph,Bn], [RK323;2-F-Ph,CF3], [RK324;2-F-Ph,CF3CH2],

[RK325;2-F-Ph,CF3CF2], [RK326;2-F-Ph,CF2H], [RK327;2-F-Ph,CF2HCH2], [RK328;3-F-Ph,Me], [RK329;3-F-Ph,Et], [RK330;3-F-Ph,Pr], [RK331;3-F-Ph,i-Pr], [RK332;3-F-Ph,c-Pr], [RK333;3-F-Ph,t-Bu], [RK334;3-F-Ph,Bu],

[RK335;3-F-Ph,t-Bu], [RK336;3-F-Ph,c-PrCH 2], [RK337;3-F-Ph,Ph],

[RK338;3-F-Ph,Bn], [RK339;3-F-Ph,CF3], [RK340;3-F-Ph,CF3CH2],

[RK341;3-F-Ph,CF3CF2], [RK342;3-F-Ph,CF2H], [RK343;3-F-Ph,CF2HCH2], [RK344;4-F-Ph,Me], [RK345;4-F-Ph,Et], [RK346;4-F-Ph,Pr], [RK347;4-F-Ph,i-Pr], [RK348;4-F-Ph,c-Pr], [RK349;4-F-Ph,t-Bu], [RK350;4-F-Ph,Bu],

[RK351;4-F-Ph,t-Bu], [RK352;4-F-Ph,c-PrCH 2], [RK353;4-F-Ph,Ph],

[RK354;4-F-Ph,Bn], [RK355;4-F-Ph,CF3], [RK356;4-F-Ph,CF3CH2],

[RK357;4-F-Ph,CF3CF2], [RK358;4-F-Ph,CF2H], [RK359;4-F-Ph,CF2HCH2], [RK360;2-MeO-Ph,Me], [RK361;2-MeO-Ph,Et], [RK362;2-MeO-Ph,Pr], [RK363;2-MeO-Ph,i-Pr] , [RK364;2-MeO-Ph,c-Pr] , [RK365;2-MeO-Ph,t-Bu],

[RK366;2-MeO-Ph,Bu], [RK367;2-MeO-Ph,t-Bu], [RK368;2-MeO-Ph,c-PrCH 2],

[RK369;2-MeO-Ph,Ph], [RK370;2-MeO-Ph,Bn], [RK371;2-MeO-Ph,CF 3],

[RK372;2-MeO-Ph,CF 3CH2], [RK373;2-MeO-Ph,CF3CF2], [RK374;2-MeO-Ph,CF 2H],

[RK375;2-MeO-Ph,CF 2HCH2], [RK376;3-MeO-Ph,Me], [RK377;3-MeO-Ph,Et], [RK378;3-MeO-Ph,Pr], [RK379;3-MeO-Ph,i-Pr], [RK380;3-MeO-Ph,c-Pr], [RK381;3-MeO-Ph,t-Bu], [RK382;3-MeO-Ph,Bu], [RK383;3-MeO-Ph,t-Bu],

[RK384;3-MeO-Ph,c-PrCH 2], [RK385;3-MeO-Ph,Ph], [RK386;3-MeO-Ph,Bn],

[RK387;3-MeO-Ph,CF 3], [RK388;3-MeO-Ph,CF 3CH2], [RK389;3-MeO-Ph,CF 3CF2],

[RK390;3-MeO-Ph,CF 2H], [RK39 1;3-MeO-Ph,CF2HCH2], [RK392;4-MeO-Ph,Me] , [RK393;4-MeO-Ph,Et], [RK394;4-MeO-Ph,Pr] , [RK395;4-MeO-Ph,i-Pr], [RK396;4-MeO-Ph,c-Pr], [RK397;4-MeO-Ph,t-Bu], [RK398;4-MeO-Ph,Bu],

[RK399;4-MeO-Ph,t-Bu], [RK400;4-MeO-Ph,c-PrCH 2], [RK401;4-MeO-Ph,Ph],

[RK402;4-MeO-Ph,Bn] , [RK403;4-MeO-Ph,CF3], [RK404;4-MeO-Ph,CF 3CH2],

[RK405;4-MeO-Ph,CF3CF2], [RK406;4-MeO-Ph,CF2H], [RK407;4-MeO-Ph,CF2HCH2 ] The compound represented by formula (XIII): [Chem.117] (wherein R25 and R3 1 are the same as defined above) wherein R3 1 and R25 represent any one combination indicated in the following sub stituent numbers RLl to RL407 (hereinafter the compounds of the substituent numbers RLl to RL407 are referred to as "Present compounds RLl to RL407", and the "Present compounds RLl to RL407" are collectively referred to as "Present compound RL") can be prepared according to the method described in the above processes. The substituent numbers RLl to RL407 as described herein represent the combinations of R3 1 and R25 in the compound represented by formula (XIII), and hereinafter are indicated by [substituent number;R 1,R25], except that the substituent numbers RL166 and RLl 67 represent that R3 1 and R25 are combined with each other to form a hete rocyclic group. For example, the substituent number RL4 represents the combination wherein R3 1 is a hydrogen atom, and R25 is an isopropyl group. For example, the Present compound RL4 indicates the compound represented by formula (XIII) wherein the substituent number is RL4, and indicates the compound represented by formula (XIII) wherein R3 1 is a hydrogen atom, and R25 is an isopropyl group as shown in the following. [Chem.118]

[Substituent number;R ,R25]: [RLl;H,Me], [RL2;H,Et], [RL3;H,Pr], [RL4;H,i-Pr],

[RL5;H,c-Pr], [RL6;H,Bu], [RL7;H,t-Bu], [RL8;H,c-PrCH 2], [RL9;H,Ph],

[RL10;H,Bn], [RL11;H,CF 3], [RL12;H,CF 3CH2], [RL13;H,CF 3CF2], [RL14;H,CF 2H],

[RL15;H,CF 2HCH 2], [RL16;Me,Me], [RL17;Me,Et], [RL18;Me,Pr], [RL19;Me,i-Pr],

[RL20;Me,c-Pr], [RL21Me,Bu], [RL22;Me,t-Bu], [RL23;Me,c-PrCH 2],

[RL24;Me,Ph], [RL25;Me,Bn], [RL26;Me,CF 3], [RL27;Me,CF 3CH2], [RL28;Me,CF 3

CF2], [RL29;Me,CF 2H], [RL30;Me,CF 2HCH 2], [RL31;Et,Me], [RL32;Et,Et], [RL33;Et,Pr], [RL34;Et,i-Pr], [RL35;Et,c-Pr], [RL36;Et,Bu], [RL37;Et,t-Bu],

[RL38;Et,c-PrCH 2], [RL39;Et,Ph], [RL40;Et,Bn], [RL41;Et,CF 3], [RL42;Et,CF 3CH2],

[RL43;Et,CF 3CF2], [RL44;Et,CF 2H], [RL45;Et,CF 2HCH 2], [RL46;Pr,Me], [RL47;Pr,Et], [RL48;Pr,Pr], [RL49;Pr,i-Pr], [RL50;Pr,c-Pr], [RL51;Pr,Bu],

[RL52;Pr,t-Bu], [RL53;Pr,c-PrCH 2], [RL54;Pr,Ph], [RL55;Pr,Bn], [RL56;Pr,CF 3],

[RL57;Pr,CF 3CH2], [RL58;Pr,CF 3CF2], [RL59;Pr,CF 2H], [RL60;Pr,CF 2HCH 2], [RL61;i-Pr,Me], [RL62;i-Pr,Et], [RL63;i-Pr,Pr], [RL64;i-Pr,i-Pr], [RL65;i-Pr,c-Pr],

[RL66;i-Pr,Bu], [RL67;i-Pr,t-Bu], [RL68;i-Pr,c-PrCH 2], [RL69;i-Pr,Ph],

[RL70;i-Pr,Bn], [RL71;i-Pr,CF 3], [RL72;i-Pr,CF 3CH2], [RL73;i-Pr,CF 3CF2],

[RL74;i-Pr,CF 2H], [RL75;i-Pr,CF 2HCH2], [RL76;c-Pr,Me], [RL77;c-Pr,Et], [RL78;c-Pr,Pr], [RL79;c-Pr,i-Pr], [RL80;c-Pr,c-Pr], [RL81;c-Pr,Bu], [RL82;c-Pr,t-Bu],

[RL83;c-Pr,c-PrCH 2], [RL84;c-Pr,Ph], [RL85;c-Pr,Bn], [RL86;c-Pr,CF 3],

[RL87;c-Pr,CF 3CH2], [RL88;c-Pr,CF 3CF2], [RL89;c-Pr,CF 2H], [RL90;c-Pr,CF 2HCH2],

[RL91;c-PrCH 2,Me], [RL92;c-PrCH 2,Et], [RL93;c-PrCH 2,Pr], [RL94;c-PrCH 2,i-Pr],

[RL95;c-PrCH 2,c-Pr], [RL96;c-PrCH 2,Bu], [RL97;c-PrCH 2,t-Bu], [RL98;c-PrCH 2

,c-PrCH2], [RL99;c-PrCH 2,Ph], [RL100;c-PrCH 2,Bn], [RL101;c-PrCH 2,CF3],

[RL102;c-PrCH 2,CF3CH2], [RL103;c-PrCH 2,CF3CF2], [RL104;c-PrCH 2,CF2H],

[RL105;c-PrCH 2,CF2HCH2], [RL106;CF 3CH2,Me], [RL107;CF3CH2,Et], [RL108;CF3

CH2,Pr], [RL109;CF3CH2,i-Pr], [RL110;CF3CH2,c-Pr], [RLlll;CF 3CH2,Bu],

[RL112;CF 3CH2,t-Bu], [RL113;CF3CH2,c-PrCH2], [RL114;CF3CH2,Ph], [RL115;CF3

CH2,Bn], [RL116;CF3CH2,CF3], [RL117;CF 3CH2,CF3CH2], [RL118;CF3CH2,CF3CF2],

[RL1 19;CF3CH2,CF2H], [RL120;CF3CH2,CF2HCH2], [RL121;CF2HCH2,Me],

[RL122;CF 2HCH2,Et], [RL123;CF2HCH2,Pr], [RL124;CF2HCH2,i-Pr], [RL125;CF2

HCH2,c-Pr], [RL126;CF2HCH2,Bu], [RL127;CF2HCH2,t-Bu], [RL128;CF2HCH2

,c-PrCH2], [RL129;CF2HCH2,Ph], [RL130;CF 2HCH2,Bn], [RL131;CF2HCH2,CF3],

[RL132;CF2HCH2,CF3CH2], [RL1 33;CF2HCH2,CF3CF2], [RL134;CF2HCH2,CF2H],

[RL135;CF 2HCH2,CF2HCH2], [RL136;MeOCH 2,Me], [RL137;MeOCH 2,Et],

[RL138;MeOCH 2,Pr], [RL139;MeOCH 2,i-Pr], [RL140;MeOCH 2,c-Pr],

[RL141;MeOCH 2,Bu], [RL142;MeOCH 2,t-Bu], [RL143;MeOCH 2,c-PrCH2],

[RL144;MeOCH 2,Ph], [RL145;MeOCH 2,Bn], [RL146;MeOCH 2,CF3],

[RL147;MeOCH 2,CF3CH2], [RL148;MeOCH 2,CF3CF2], [RL149;MeOCH 2,CF2H],

[RL150;MeOCH 2,CF2HCH2], [RL151;EtOCH 2,Me], [RL152;EtOCH 2,Et],

[RL153;EtOCH 2,Pr], [RL154;EtOCH 2,i-Pr], [RL155;EtOCH 2,c-Pr], [RL156;EtOCH 2

,Bu], [RL157;EtOCH 2,t-Bu], [RL158;EtOCH 2,c-PrCH2], [RL159;EtOCH 2,Ph],

[RL160;EtOCH 2,Bn], [RL161;EtOCH 2,CF3], [RL162;EtOCH 2,CF3CH2],

[RL163;EtOCH2,CF3CF2], [RL164;EtOCH 2,CF2H], [RL165;EtOCH2,CF2HCH2],

[RL166;CH 2CH2CH2], [RL167;CH 2CH2CH2CH2], [RL168;t-Bu,Me], [RL169;t-Bu,Et], [RL170;t-Bu,Pr], [RL171;t-Bu,i-Pr], [RL172;t-Bu,c-Pr], [RL173;t-Bu,t-Bu],

[RL174;t-Bu,Bu], [RL175;t-Bu,t-Bu], [RL176;t-Bu,c-PrCH 2], [RL177;t-Bu,Ph],

[RL178;t-Bu,Bn], [RL179;t-Bu,CF 3], [RL180;t-Bu,CF 3CH2], [RL181;t-Bu,CF 3CF2],

[RL182;t-Bu,CF 2H], [RL183;t-Bu,CF 2HCH2], [RL184;i-Bu,Me], [RL185;i-Bu,Et], [RL186;i-Bu,Pr], [RL187;i-Bu,i-Pr], [RL188;i-Bu,c-Pr], [RL189;i-Bu,t-Bu],

[RL190;i-Bu,Bu], [RL191;i-Bu,t-Bu], [RL192;i-Bu,c-PrCH 2], [RL193;i-Bu,Ph],

[RL194;i-Bu,Bn], [RL195;i-Bu,CF 3], [RL196;i-Bu,CF 3CH2], [RL197;i-Bu,CF 3CF2], [RL198;i-Bu,CF 2H], [RL199;i-Bu,CF 2HCH2], [RL200;HCCCH 2,Me],

[RL201;HCCCH 2,Et], [RL202;HCCCH 2,Pr], [RL203;HCCCH 2,i-Pr], [RL204;HCCCH

2,c-Pr], [RL205;HCCCH 2,t-Bu], [RL206;HCCCH 2,Bu], [RL207;HCCCH 2,t-Bu],

[RL208;HCCCH 2,c-PrCH2], [RL209;HCCCH 2,Ph], [RL210;HCCCH 2,Bn],

[RL21 1;HCCCH2,CF3], [RL212;HCCCH ,CF3CH ], [RL213;HCCCH ,CF3CF ],

[RL214;HCCCH 2,CF2H], [RL215;HCCCH2,CF2HCH2], [RL216;MeCCCH2,Me] ,

[RL217;MeCCCH 2,Et], [RL218;MeCCCH 2,Pr], [RL219;MeCCCH 2,i-Pr],

[RL220;MeCCCH 2,c-Pr], [RL221;MeCCCH 2,t-Bu], [RL222;MeCCCH 2,Bu],

[RL223;MeCCCH2,t-Bu] , [RL224;MeCCCH 2,c-PrCH2], [RL225;MeCCCH2,Ph],

[RL226;MeCCCH2,Bn], [RL227;MeCCCH2,CF3], [RL228;MeCCCH2,CF3CH2],

[RL229;MeCCCH 2,CF3CF2], [RL230;MeCCCH 2,CF2H], [RL23 1;MeCCCH2,CF2HCH2

1, [RL232;MeSCH 2,Me], [RL233;MeSCH 2,Et], [RL234;MeSCH 2,Pr], [RL235;MeSCH

2,i-Pr], [RL236;MeSCH 2,c-Pr], [RL237;MeSCH 2,t-Bu], [RL238;MeSCH 2,Bu],

[RL239;MeSCH 2,t-Bu], [RL240;MeSCH 2,c-PrCH2], [RL241;MeSCH 2,Ph],

[RL242;MeSCH 2,Bn], [RL243;MeSCH 2,CF3], [RL244;MeSCH 2,CF3CH2],

[RL245;MeSCH2,CF3CF2], [RL246;MeSCH2,CF2H], [RL247;MeSCH2,CF2HCH2],

[RL248;EtSCH 2,Me], [RL249;EtSCH 2,Et], [RL250;EtSCH 2,Pr],

[RL251;EtSCH 2,i-Pr], [RL252;EtSCH 2,c-Pr], [RL253;EtSCH 2,t-Bu], [RL254;EtSCH 2

,Bu], [RL255;EtSCH 2,t-Bu], [RL256;EtSCH 2,c-PrCH2], [RL257;EtSCH 2,Ph],

[RL258;EtSCH 2,Bn], [RL259;EtSCH 2,CF3], [RL260;EtSCH 2,CF3CH2], [RL261;EtSCH

2,CF3CF2], [RL262;EtSCH 2,CF2H], [RL263;EtSCH 2,CF2HCH2], [RL264;2-Me-Ph,Me], [RL265;2-Me-Ph,Et], [RL266;2-Me-Ph,Pr], [RL267;2-Me-Ph,i-Pr], [RL268;2-Me-Ph,c-Pr], [RL269;2-Me-Ph,t-Bu], [RL270;2-Me-Ph,Bu],

[RL27 1;2-Me-Ph,t-Bu] , [RL272;2-Me-Ph,c-PrCH 2], [RL273;2-Me-Ph,Ph] ,

[RL274;2-Me-Ph,Bn], [RL275;2-Me-Ph,CF 3], [RL276;2-Me-Ph,CF 3CH2],

[RL277;2-Me-Ph,CF 3CF2], [RL278;2-Me-Ph,CF 2H], [RL279;2-Me-Ph,CF 2HCH2], [RL280;3-Me-Ph,Me], [RL281;3-Me-Ph,Et], [RL282;3-Me-Ph,Pr], [RL283;3-Me-Ph,i-Pr], [RL284;3-Me-Ph,c-Pr], [RL285;3-Me-Ph,t-Bu],

[RL286;3-Me-Ph,Bu], [RL287;3-Me-Ph,t-Bu], [RL288;3-Me-Ph,c-PrCH 2],

[RL289;3-Me-Ph,Ph], [RL290;3-Me-Ph,Bn], [RL291;3-Me-Ph,CF 3],

[RL292;3-Me-Ph,CF 3CH2], [RL293;3-Me-Ph,CF 3CF2], [RL294;3-Me-Ph,CF 2H],

[RL295;3-Me-Ph,CF 2HCH2], [RL296;4-Me-Ph,Me] , [RL297;4-Me-Ph,Et] , [RL298;4-Me-Ph,Pr], [RL299;4-Me-Ph,i-Pr], [RL300;4-Me-Ph,c-Pr], [RL301;4-Me-Ph,t-Bu], [RL302;4-Me-Ph,Bu], [RL303;4-Me-Ph,t-Bu],

[RL304;4-Me-Ph,c-PrCH 2], [RL305;4-Me-Ph,Ph] , [RL306;4-Me-Ph,Bn] ,

[RL307;4-Me-Ph,CF 3], [RL308;4-Me-Ph,CF 3CH2], [RL309;4-Me-Ph,CF 3CF2],

[RL310;4-Me-Ph,CF 2H], [RL31 l;4-Me-Ph,CF 2HCH2], [RL312;2-F-Ph,Me], [RL313;2-F-Ph,Et], [RL314;2-F-Ph,Pr], [RL315;2-F-Ph,i-Pr], [RL316;2-F-Ph,c-Pr], [RL317;2-F-Ph,t-Bu], [RL318;2-F-Ph,Bu], [RL319;2-F-Ph,t-Bu],

[RL320;2-F-Ph,c-PrCH 2], [RL321;2-F-Ph,Ph], [RL322;2-F-Ph,Bn], [RL323;2-F-Ph,CF

3], [RL324;2-F-Ph,CF3CH2], [RL325;2-F-Ph,CF 3CF2], [RL326;2-F-Ph,CF2H],

[RL327;2-F-Ph,CF 2HCH2], [RL328;3-F-Ph,Me], [RL329;3-F-Ph,Et], [RL330;3-F-Ph,Pr], [RL331;3-F-Ph,i-Pr], [RL332;3-F-Ph,c-Pr], [RL333;3-F-Ph,t-Bu],

[RL334;3-F-Ph,Bu], [RL335;3-F-Ph,t-Bu], [RL336;3-F-Ph,c-PrCH 2],

[RL337;3-F-Ph,Ph], [RL338;3-F-Ph,Bn], [RL339;3-F-Ph,CF3], [RL340;3-F-Ph,CF 3CH

2] , [RL341;3-F-Ph,CF3CF2], [RL342;3-F-Ph,CF2H], [RL343;3-F-Ph,CF2HCH2], [RL344;4-F-Ph,Me], [RL345;4-F-Ph,Et], [RL346;4-F-Ph,Pr], [RL347;4-F-Ph,i-Pr], [RL348;4-F-Ph,c-Pr], [RL349;4-F-Ph,t-Bu], [RL350;4-F-Ph,Bu],

[RL351;4-F-Ph,t-Bu], [RL352;4-F-Ph,c-PrCH 2], [RL353;4-F-Ph,Ph],

[RL354;4-F-Ph,Bn], [RL355;4-F-Ph,CF3], [RL356;4-F-Ph,CF 3CH2],

[RL357;4-F-Ph,CF3CF2], [RL358;4-F-Ph,CF2H], [RL359;4-F-Ph,CF 2HCH2], [RL360;2-MeO-Ph,Me], [RL361;2-MeO-Ph,Et], [RL362;2-MeO-Ph,Pr], [RL363;2-MeO-Ph,i-Pr], [RL364;2-MeO-Ph,c-Pr], [RL365;2-MeO-Ph,t-Bu],

[RL366;2-MeO-Ph,Bu] , [RL367;2-MeO-Ph,t-Bu], [RL368;2-MeO-Ph,c-PrCH2],

[RL369;2-MeO-Ph,Ph], [RL370;2-MeO-Ph,Bn], [RL371;2-MeO-Ph,CF 3],

[RL372;2-MeO-Ph,CF 3CH2], [RL373;2-MeO-Ph,CF3CF2], [RL374;2-MeO-Ph,CF 2H],

[RL375;2-MeO-Ph,CF 2HCH2], [RL376;3-MeO-Ph,Me], [RL377;3-MeO-Ph,Et], [RL378;3-MeO-Ph,Pr], [RL379;3-MeO-Ph,i-Pr], [RL380;3-MeO-Ph,c-Pr], [RL381;3-MeO-Ph,t-Bu], [RL382;3-MeO-Ph,Bu], [RL383;3-MeO-Ph,t-Bu],

[RL384;3-MeO-Ph,c-PrCH 2], [RL385;3-MeO-Ph,Ph], [RL386;3-MeO-Ph,Bn],

[RL387;3-MeO-Ph,CF 3], [RL388;3-MeO-Ph,CF 3CH2], [RL389;3-MeO-Ph,CF 3CF2],

[RL390;3-MeO-Ph,CF 2H], [RL39 1;3-MeO-Ph,CF2HCH2], [RL392;4-MeO-Ph,Me] , [RL393;4-MeO-Ph,Et] , [RL394;4-MeO-Ph,Pr] , [RL395;4-MeO-Ph,i-Pr] , [RL396;4-MeO-Ph,c-Pr], [RL397;4-MeO-Ph,t-Bu] , [RL398;4-MeO-Ph,Bu],

[RL399;4-MeO-Ph,t-Bu] , [RL400;4-MeO-Ph,c-PrCH 2], [RL401;4-MeO-Ph,Ph] ,

[RL402;4-MeO-Ph,Bn] , [RL403;4-MeO-Ph,CF3], [RL404;4-MeO-Ph,CF 3CH2],

[RL405;4-MeO-Ph,CF3CF2], [RL406;4-MeO-Ph,CF2H], [RL407;4-MeO-Ph,CF2HCH2] The compound represented by formula (XIV): [Chem.119]

(wherein R32 and R33 are independently of each other a hydrogen atom, a C1-C6 alkyl group optionally having one or more substituents selected from the group consisting of Group E and Group F, a C3-C6 alkynyl group optionally having one or more halogen atoms, a C1-C6 alkoxy group optionally having one or more halogen atoms, a C3-C6 cycloalkyl group optionally having one or more substituents selected from Group D, or a phenyl group optionally having one or more substituents selected from Group D, or R32 and R33 may be combined with each other to form a 3 to 6 membered heterocyclic group (wherein said 3 to 6 membered heterocyclic group may optionally have one or more substituents selected from Group D)) wherein R32 and R33 represent any one combination indicated in the following substituent numbers RMl to RMl 30 (hereinafter the compounds of the substituent numbers RMl to RM130 are referred to as "Present compounds RMl to RM130", and the "Present compounds RMl to RMl 30" are collectively referred to as "Present compound RM") can be prepared according to the method described in the above processes. The substituent numbers RMl to RMl 30 as described herein represent the com binations of R32 and R33 in the compound represented by formula (XIV), and hereinafter are indicated by [substituent number;R 2,R33], except that the substituent numbers RMl 27 to RMl 29 represent that R32 and R33 are combined with each other to form a heterocyclic group. For example, the substituent number RM4 represents the combination wherein R32 is a hydrogen atom, and R 12 is an isopropyl group. [0190] The 3 to 6 membered heterocyclic group formed by combining R32 and R33 with each other represents any one structure of the followings (ZB1 to ZB4 and ZB7 to ZB21) (wherein the symbol "·" represents the point of attachment). [Ch

(ZB1 ) (ZB2) (ZB3) (ZB4) (ZB5) (ZB6) (ZB7)

(ZB9) (ZB1 0) (ZB1 1) (ZB12) (ZB1 3) (ZB14) (ZB1 5)

[0191] For example, the Present compound RM4 indicates the compound represented by formula (XIV) wherein the substituent number is RM4, and indicates the compound represented by formula (XIV) wherein R32 is a hydrogen atom, and R33 is an isopropyl group as shown in the following. [Chem.121]

[Substituent number;R ,R33]: [RMl;H,Me], [RM2;H,Et], [RM3;H,Pr], [RM4;H,i-Pr],

[RM5;H,c-Pr], [RM6;H,Bu], [RM7;H,t-Bu], [RM8;H,c-PrCH 2], [RM9;H,Ph],

[RM10;H,Bn], [RM11;H,CF3CH2], [RM12;H,CF2HCH2], [RM13;H,CHCCH 2],

[RM14;H,MeCCCH 2], [RM15;Me,Me], [RM16;Me,Et], [RM17;Me,Pr], [RM18;Me,i-Pr], [RM19;Me,c-Pr], [RM20;Me,Bu], [RM21;Me,t-Bu],

[RM22;Me,c-PrCH 2], [RM23;Me,Ph], [RM24;Me,Bn], [RM25;Me,CF3CH2],

[RM26;Me,CF 2HCH2], [RM27;Me,CHCCH 2], [RM28;Me,MeCCCH 2], [RM29;Et,Et], [RM30;Et,Pr], [RM31;Et,i-Pr], [RM32;Et,c-Pr], [RM33;Et,Bu], [RM34;Et,t-Bu],

[RM35;Et,c-PrCH 2], [RM36;Et,Ph], [RM37;Et,Bn], [RM38;Et,CF3CH2], [RM39;Et,CF

2HCH2], [RM40;Et,CHCCH 2], [RM41;Et,MeCCCH 2], [RM42;Pr,Pr], [RM43;Pr,i-Pr],

[RM44;Prc-Pr], [RM45;Pr,Bu], [RM46;Pr,t-Bu], [RM47;Pr,c-PrCH 2], [RM48;Pr,Ph],

[RM49;Pr,Bn], [RM50;Pr,CF3CH2], [RM51;Pr,CF2HCH2], [RM52;Pr,CHCCH 2],

[RM53;Pr,MeCCCH 2], [RM54;i-Pr,i-Pr], [RM55;i-Pr,c-Pr], [RM56;i-Pr,Bu],

[RM57;i-Pr,t-Bu], [RM58;i-Pr,c-PrCH 2], [RM59;i-Pr,Ph], [RM60;i-Pr,Bn],

[RM61;i-Pr,CF3CH2], [RM62;i-Pr,CF2HCH2], [RM63;i-Pr,CHCCH 2],

[RM64;i-Pr,MeCCCH 2], [RM65;c-Pr,c-Pr], [RM66;c-Pr,Bu], [RM67;c-Pr,t-Bu],

[RM68;c-Pr,c-PrCH 2], [RM69;c-Pr,Ph], [RM70;c-Pr,Bn], [RM71;c-Pr,CF3CH2],

[RM72;c-Pr,CF2HCH2], [RM73;c-Pr,CHCCH 2], [RM74;c-Pr,MeCCCH 2],

[RM75;c-PrCH2,Bu], [RM76;c-PrCH2,t-Bu], [RM77;c-PrCH2,c-PrCH2],

[RM78;c-PrCH2,Ph], [RM79;c-PrCH2,Bn], [RM80;c-PrCH2,CF3CH2], [RM8 1;c-PrCH2

,CF2HCH2], [RM82;c-PrCH2,CHCCH2], [RM83;c-PrCH2,MeCCCH2], [RM84;CF3CH2

,Bu], [RM85;CF3CH2,t-Bu], [RM86;CF3CH2,Ph], [RM87;CF3CH2,Bn], [RM88;CF3CH2

,CF3CH2], [RM89;CF3CH2,CF2HCH2], [RM90;CF3CH2,CHCCH2], [RM91;CF3CH2

,MeCCCH2], [RM92;CF2HCH2,Bu], [RM93;CF2HCH2,t-Bu], [RM94;CF2HCH2,Ph],

[RM95;CF2HCH2,Bn] , [RM96;CF2HCH2,CF2HCH2], [RM97;CF2HCH2,CHCCH2],

[RM98;CF2HCH2,MeCCCH2], [RM99;MeOCH2,Me], [RM100;MeOCH 2,Et],

[RM101;MeOCH 2,Pr], [RM102;MeOCH 2,i-Pr], [RM103;MeOCH 2,c-Pr],

[RM104;MeOCH 2,Bu], [RM105;MeOCH 2,t-Bu], [RM106;MeOCH 2,c-PrCH2],

[RM107;MeOCH 2,Ph], [RM108;MeOCH 2,Bn], [RM109;MeOCH 2,CF3CH2],

[RM110;MeOCH 2,CF2HCH2], [RMlll;MeOCH 2,CHCCH2], [RM112;MeOCH 2

,MeCCCH2], [RM113;EtOCH 2,Me], [RM114;EtOCH 2,Et], [RM115;EtOCH 2,Pr],

[RM116;EtOCH 2,i-Pr], [RM117;EtOCH 2,c-Pr], [RM118;EtOCH 2,Bu], [RM119;EtOCH 2,t-Bu], [RM120;EtOCH 2,c-PrCH 2], [RM121;EtOCH 2,Ph],

[RM122;EtOCH 2,Bn], [RM123;EtOCH 2,CF3CH2], [RM124;EtOCH 2,CF2HCH 2],

[RM 125;EtOCH 2,CHCCH 2], [RM 126;EtOCH 2,MeCCCH 2], [RM 127;CH2(CH2)2CH2],

[RM128;CH 2(CH2)3CH2], [RM129;CH 2CH2OCH 2CH2], [RM130;H,H] The compound represented by formula (XV): [Chem.122

(wherein R32 and R33 are the same as defined above) wherein R32 and R33 represent any one combination indicated in the following sub stituent numbers RNl to RNl 30 (hereinafter the compounds of the substituent numbers RNl to RNl 30 are referred to as "Present compounds RNl to RNl 30", and the "Present compounds RNl to RNl 30" are collectively referred to as "Present compound RN") can be prepared according to the method described in the above processes. The substituent numbers RNl to RNl 30 as described herein represent the com binations of R32 and R33 in the compound represented by formula (XV), and hereinafter are indicated by [substituent number;R 2,R33], except that the substituent numbers RNl 27 to RNl 29 represent that R32 and R33 are combined with each other to form a heterocyclic group. For example, the substituent number RN4 represents the combination wherein R32 is a hydrogen atom, and R33 is an isopropyl group. For example, the Present compound RN4 indicates the compound represented by formula (XV) wherein the substituent number is RN4, and indicates the compound rep resented by formula (XV) wherein R32 is a hydrogen atom, and R33 is an isopropyl group as shown in the following. [Chem.123]

[Substituent number;R ,R33]: [RNl;H,Me], [RN2;H,Et], [RN3;H,Pr], [RN4;H,i-Pr],

[RN5;H,c-Pr], [RN6;H,Bu], [RN7;H,t-Bu], [RN8;H,c-PrCH 2], [RN9;H,Ph], [RN10;H,Bn], [RN11;H,CF3CH2], [RN12;H,CF2HCH2], [RN13;H,CHCCH 2],

[RN14;H,MeCCCH 2], [RN15;Me,Me], [RN16;Me,Et], [RN17;Me,Pr], [RN18;Me,i-Pr], [RN19;Me,c-Pr], [RN20;Me,Bu], [RN21;Me,t-Bu],

[RN22;Me,c-PrCH 2], [RN23;Me,Ph], [RN24;Me,Bn], [RN25;Me,CF3CH2],

[RN26;Me,CF2HCH2], [RN27;Me,CHCCH 2], [RN28;Me,MeCCCH 2], [RN29;Et,Et], [RN30;Et,Pr], [RN31;Et,i-Pr], [RN32;Et,c-Pr], [RN33;Et,Bu], [RN34;Et,t-Bu],

[RN35;Et,c-PrCH 2], [RN36;Et,Ph], [RN37;Et,Bn], [RN38;Et,CF3CH2], [RN39;Et,CF2

HCH2], [RN40;Et,CHCCH 2], [RN41;Et,MeCCCH 2], [RN42;Pr,Pr], [RN43;Pr,i-Pr],

[RN44;Prc-Pr], [RN45;Pr,Bu], [RN46;Pr,t-Bu], [RN47;Pr,c-PrCH2], [RN48;Pr,Ph],

[RN49;Pr,Bn], [RN50;Pr,CF3CH2], [RN51;Pr,CF2HCH2], [RN52;Pr,CHCCH2],

[RN53;Pr,MeCCCH 2], [RN54;i-Pr,i-Pr], [RN55;i-Pr,c-Pr], [RN56;i-Pr,Bu],

[RN57;i-Pr,t-Bu], [RN58;i-Pr,c-PrCH 2], [RN59;i-Pr,Ph], [RN60;i-Pr,Bn],

[RN61;i-Pr,CF3CH2], [RN62;i-Pr,CF2HCH2], [RN63;i-Pr,CHCCH 2],

[RN64;i-Pr,MeCCCH 2], [RN65;c-Pr,c-Pr], [RN66;c-Pr,Bu], [RN67;c-Pr,t-Bu],

[RN68;c-Pr,c-PrCH 2], [RN69;c-Pr,Ph], [RN70;c-Pr,Bn], [RN71;c-Pr,CF3CH2],

[RN72;c-Pr,CF2HCH2], [RN73;c-Pr,CHCCH 2], [RN74;c-Pr,MeCCCH 2],

[RN75;c-PrCH2,Bu], [RN76;c-PrCH2,t-Bu], [RN77;c-PrCH2,c-PrCH2], [RN78;c-PrCH2

,Ph], [RN79;c-PrCH2,Bn], [RN80;c-PrCH2,CF3CH2], [RN81;c-PrCH2,CF2HCH2],

[RN82;c-PrCH2,CHCCH2], [RN83;c-PrCH2,MeCCCH2], [RN84;CF3CH2,Bu],

[RN85;CF3CH2,t-Bu], [RN86;CF3CH2,Ph], [RN87;CF3CH2,Bn], [RN88;CF3CH2,CF3

CH2], [RN89;CF3CH2,CF2HCH2], [RN90;CF3CH2,CHCCH2], [RN91;CF3CH2

,MeCCCH2], [RN92;CF2HCH2,Bu], [RN93;CF2HCH2,t-Bu], [RN94;CF2HCH2,Ph],

[RN95;CF2HCH2,Bn], [RN96;CF2HCH2,CF2HCH2], [RN97;CF2HCH2,CHCCH2],

[RN98;CF2HCH2,MeCCCH2], [RN99;MeOCH2,Me], [RN100;MeOCH 2,Et],

[RN101;MeOCH 2,Pr], [RN102;MeOCH 2,i-Pr], [RN103;MeOCH 2,c-Pr],

[RN104;MeOCH 2,Bu], [RN105;MeOCH 2,t-Bu], [RN106;MeOCH 2,c-PrCH2],

[RN107;MeOCH 2,Ph], [RN108;MeOCH2,Bn], [RN109;MeOCH 2,CF3CH2],

[RN110;MeOCH 2,CF2HCH2], [RNlll;MeOCH 2,CHCCH2], [RN112;MeOCH2

,MeCCCH2], [RN113;EtOCH2,Me], [RN114;EtOCH2,Et], [RN115;EtOCH2,Pr],

[RN116;EtOCH2,i-Pr], [RN117;EtOCH2,c-Pr], [RN118;EtOCH2,Bu], [RN119;EtOCH2

,t-Bu], [RN120;EtOCH2,c-PrCH2], [RN121;EtOCH2,Ph], [RN122;EtOCH2,Bn],

[RN123;EtOCH2,CF3CH2], [RN124;EtOCH 2,CF2HCH2], [RN125;EtOCH2,CHCCH2],

[RN126;EtOCH2,MeCCCH2], [RN127;CH2(CH2)2CH2], [RN128;CH2(CH2)3CH2],

[RN129;CH2CH2OCH2CH2], [RN130;H,H] The compound represented by formula (XVI): [Chem.124]

(wherein R32 and R33 are the same as defined above) wherein R32 and R33 represent any one combination indicated in the following sub stituent numbers ROl to ROl 30 (hereinafter the compounds of the substituent numbers ROl to ROl 30 are referred to as "Present compounds ROl to ROl 30", and the "Present compounds ROl to ROl 30" are collectively referred to as "Present compound RO") can be prepared according to the method described in the above processes. The substituent numbers ROl to ROl 30 as described herein represent the com binations of R32 and R33 in the compound represented by formula (XVI), and hereinafter are indicated by [substituent number;R 2,R33], except that the substituent numbers ROl 27 to ROl 29 represent that R32 and R33 are combined with each other to form a heterocyclic group. For example, the substituent number R04 represents the combination wherein R32 is a hydrogen atom, and R33 is an isopropyl group. For example, the Present compound R04 indicates the compound represented by formula (XVI) wherein the substituent number is R04, and indicates the compound represented by formula (XVI) wherein R32 is a hydrogen atom, and R33 is an isopropyl group as shown in the following. [Chem.125]

[Substituent number;R ,R33]: [R01;H,Me], [R02;H,Et], [R03;H,Pr], [R04;H,i-Pr],

[R05;H,c-Pr], [R06;H,Bu], [R07;H,t-Bu], [R08;H,c-PrCH 2], [R09;H,Ph],

[RO10;H,Bn], [R011;H,CF 3CH2], [R012;H,CF 2HCH 2], [R013;H,CHCCH 2],

[R014;H,MeCCCH 2], [R015;Me,Me], [R016;Me,Et], [R017;Me,Pr], [R018;Me,i-Pr], [R019;Me,c-Pr], [RO20;Me,Bu], [R021;Me,t-Bu],

[R022;Me,c-PrCH 2], [R023;Me,Ph], [R024;Me,Bn], [R025;Me,CF 3CH2],

[R026;Me,CF 2HCH 2], [R027;Me,CHCCH 2], [R028;Me,MeCCCH 2], [R029;Et,Et], [RO30;Et,Pr], [R031;Et,i-Pr], [R032;Et,c-Pr], [R033;Et,Bu], [R034;Et,t-Bu], [R035;Et,c-PrCH 2], [R036;Et,Ph], [R037;Et,Bn], [R038;Et,CF 3CH2], [R039;Et,CF 2

HCH2], [RO40;Et,CHCCH2], [R041;Et,MeCCCH 2], [R042;Pr,Pr], [R043;Pr,i-Pr], [R044;Prc-Pr], [R045;Pr,Bu], [R046;Pr,t-Bu], [R047;Pr,c-PrCH 2], [R048;Pr,Ph],

[R049;Pr,Bn], [RO50;Pr,CF3CH2], [R051;Pr,CF 2HCH2], [R052;Pr,CHCCH 2],

[R053;Pr,MeCCCH 2], [R054;i-Pr,i-Pr], [R055;i-Pr,c-Pr], [R056;i-Pr,Bu],

[R057;i-Pr,t-Bu], [R058;i-Pr,c-PrCH 2], [R059;i-Pr,Ph], [RO60;i-Pr,Bn],

[R061;i-Pr,CF 3CH2], [R062;i-Pr,CF 2HCH2], [R063;i-Pr,CHCCH 2],

[R064;i-Pr,MeCCCH 2], [R065;c-Pr,c-Pr], [R066;c-Pr,Bu], [R067;c-Pr,t-Bu],

[R068;c-Pr,c-PrCH 2], [R069;c-Pr,Ph], [RO70;c-Pr,Bn], [R071;c-Pr,CF 3CH2],

[R072;c-Pr,CF 2HCH2], [R073;c-Pr,CHCCH 2], [R074;c-Pr,MeCCCH 2],

[R075;c-PrCH 2,Bu], [R076;c-PrCH 2,t-Bu], [R077;c-PrCH 2,c-PrCH2], [R078;c-PrCH 2

,Ph], [R079;c-PrCH 2,Bn], [RO80;c-PrCH2,CF3CH2], [R081;c-PrCH 2,CF2HCH2],

[R082;c-PrCH 2,CHCCH2], [R083;c-PrCH 2,MeCCCH2], [R084;CF 3CH2,Bu],

[R085;CF 3CH2,t-Bu], [R086;CF 3CH2,Ph], [R087;CF 3CH2,Bn], [R088;CF 3CH2,CF3

CH2], [R089;CF 3CH2,CF2HCH2], [RO90;CF3CH2,CHCCH2], [R091;CF 3CH2

,MeCCCH2], [R092;CF 2HCH2,Bu], [R093;CF 2HCH2,t-Bu], [R094;CF 2HCH2,Ph],

[R095 ;CF2HCH2,Bn], [R096 ;CF2HCH2,CF2HCH2], [R097 ;CF2HCH2,CHCCH2],

[R098;CF 2HCH2,MeCCCH2], [R099;MeOCH 2,Me], [RO100;MeOCH2,Et],

[RO101;MeOCH2,Pr], [RO102;MeOCH2,i-Pr], [RO103;MeOCH2,c-Pr],

[RO104;MeOCH2,Bu], [RO105;MeOCH2,t-Bu], [RO106;MeOCH2,c-PrCH2], [RO107;MeOCH2,Ph], [RO108;MeOCH2,Bn], [RO109;MeOCH2,CF3CH2],

[RO110;MeOCH2,CF2HCH2], [R0111;MeOCH 2,CHCCH2], [R0112;MeOCH 2

,MeCCCH2], [R0113;EtOCH 2,Me], [R0114;EtOCH 2,Et], [R0115;EtOCH 2,Pr],

[R0116;EtOCH 2,i-Pr], [R0117;EtOCH 2,c-Pr], [R0118;EtOCH 2,Bu], [R0119;EtOCH 2

,t-Bu], [RO120;EtOCH2,c-PrCH2], [R0121;EtOCH 2,Ph], [R0122;EtOCH 2,Bn],

[RO123 ;EtOCH2,CF3CH2], [RO124;EtOCH2,CF2HCH2], [RO125 ;EtOCH2,CHCCH2],

[RO126;EtOCH2,MeCCCH2], [RO127;CH2(CH2)2CH2], [RO128 ;CH2(CH2)3CH2],

[RO129;CH2CH2OCH2CH2], [RO130;H,H] The compound represented by formula (XVII): [Chem.126]

(wherein R32 and R33 are the same as defined above) wherein R32 and R33 represent any one combination indicated in the following substituent numbers RPl to RP130 (hereinafter the compounds of the substituent numbers RPl to RP130 are referred to as "Present compounds RPl to RP130", and the "Present compounds RPl to RP130" are collectively referred to as "Present compound RP") can be prepared according to the method described in the above processes. The substituent numbers RPl to RPl 30 as described herein represent the combinations of R32 and R33 in the compound represented by formula (XVII), and hereinafter are indicated by [substituent number;R 2,R33], except that the substituent numbers RP127 to RPl 29 represent that R32 and R33 are combined with each other to form a hete rocyclic group. For example, the substituent number RP4 represents the combination wherein R32 is a hydrogen atom, and R33 is an isopropyl group. For example, the Present compound RP4 indicates the compound represented by formula (XVII) wherein the substituent number is RP4, and indicates the compound represented by formula (XVII) wherein R32 is a hydrogen atom, and R33 is an isopropyl group as shown in the following. [Chem.127

[Substituent number;R ,R33]: [RPl;H,Me], [RP2;H,Et], [RP3;H,Pr], [RP4;H,i-Pr],

[RP5;H,c-Pr], [RP6;H,Bu], [RP7;H,t-Bu], [RP8;H,c-PrCH 2], [RP9;H,Ph],

[RP10;H,Bn], [RP11;H,CF 3CH2], [RP12;H,CF 2HCH 2], [RP13;H,CHCCH 2],

[RP14;H,MeCCCH 2], [RP15;Me,Me], [RP16;Me,Et], [RP17;Me,Pr], [RP18;Me,i-Pr],

[RP19;Me,c-Pr], [RP20;Me,Bu], [RP21;Me,t-Bu], [RP22;Me,c-PrCH 2],

[RP23;Me,Ph], [RP24;Me,Bn], [RP25;Me,CF 3CH2], [RP26;Me,CF 2HCH 2],

[RP27;Me,CHCCH 2], [RP28;Me,MeCCCH 2], [RP29;Et,Et], [RP30;Et,Pr],

[RP31;Et,i-Pr], [RP32;Et,c-Pr], [RP33;Et,Bu], [RP34;Et,t-Bu], [RP35;Et,c-PrCH 2],

[RP36;Et,Ph], [RP37;Et,Bn], [RP38;Et,CF 3CH2], [RP39;Et,CF 2HCH 2],

[RP40;Et,CHCCH 2], [RP41;Et,MeCCCH 2], [RP42;Pr,Pr], [RP43;Pr,i-Pr],

[RP44;Prc-Pr], [RP45;Pr,Bu], [RP46;Pr,t-Bu], [RP47;Pr,c-PrCH 2], [RP48;Pr,Ph],

[RP49;Pr,Bn], [RP50;Pr,CF 3CH2], [RP51;Pr,CF 2HCH 2], [RP52;Pr,CHCCH 2],

[RP53;Pr,MeCCCH 2], [RP54;i-Pr,i-Pr], [RP55;i-Pr,c-Pr], [RP56;i-Pr,Bu],

[RP57;i-Pr,t-Bu], [RP58;i-Pr,c-PrCH 2], [RP59;i-Pr,Ph], [RP60;i-Pr,Bn], [RP61;i-Pr,CF

3CH2], [RP62;i-Pr,CF 2HCH 2], [RP63;i-Pr,CHCCH 2], [RP64;i-Pr,MeCCCH 2], [RP65;c-Pr,c-Pr], [RP66;c-Pr,Bu], [RP67;c-Pr,t-Bu], [RP68;c-Pr,c-PrCH 2],

[RP69;c-Pr,Ph], [RP70;c-Pr,Bn], [RP71;c-Pr,CF 3CH2], [RP72;c-Pr,CF 2HCH 2],

[RP73;c-Pr,CHCCH 2], [RP74;c-Pr,MeCCCH 2], [RP75;c-PrCH 2,Bu], [RP76;c-PrCH 2

,t-Bu], [RP77;c-PrCH 2,c-PrCH 2], [RP78;c-PrCH 2,Ph], [RP79;c-PrCH 2,Bn],

[RP80;c-PrCH 2,CF3CH2], [RP8 1;c-PrCH 2,CF2HCH 2], [RP82;c-PrCH 2,CHCCH 2],

[RP83;c-PrCH 2,MeCCCH 2], [RP84;CF 3CH2,Bu], [RP85;CF 3CH2,t-Bu], [RP86;CF 3CH2

,Ph], [RP87;CF 3CH2,Bn], [RP88;CF 3CH2,CF3CH2], [RP89;CF 3CH2,CF2HCH 2],

[RP90;CF 3CH2,CHCCH 2], [RP91;CF 3CH2,MeCCCH 2], [RP92;CF 2HCH 2,Bu],

[RP93;CF 2HCH 2,t-Bu], [RP94;CF 2HCH 2,Ph], [RP95;CF 2HCH 2,Bn], [RP96;CF 2HCH 2

,CF2HCH 2], [RP97;CF 2HCH 2,CHCCH 2], [RP98;CF 2HCH 2,MeCCCH 2],

[RP99;MeOCH 2,Me], [RP100;MeOCH 2,Et], [RP101;MeOCH 2,Pr], [RP102;MeOCH 2

,i-Pr], [RP103;MeOCH 2,c-Pr], [RP104;MeOCH 2,Bu], [RP105;MeOCH 2,t-Bu],

[RP106;MeOCH 2,c-PrCH 2], [RP107;MeOCH 2,Ph], [RP108;MeOCH 2,Bn],

[RP109;MeOCH 2,CF3CH2], [RPl 10;MeOCH 2,CF2HCH 2], [RPl 11;MeOCH 2,CHCCH 2

], [RP112;MeOCH 2,MeCCCH 2], [RP113;EtOCH 2,Me], [RP114;EtOCH 2,Et],

[RP115;EtOCH 2,Pr], [RP116;EtOCH 2,i-Pr], [RP117;EtOCH 2,c-Pr], [RP118;EtOCH 2

,Bu], [RP119;EtOCH 2,t-Bu], [RP120;EtOCH 2,c-PrCH 2], [RP121;EtOCH 2,Ph],

[RP122;EtOCH 2,Bn], [RP123;EtOCH 2,CF3CH2], [RP124;EtOCH 2,CF2HCH 2],

[RP125;EtOCH 2,CHCCH 2], [RP126;EtOCH 2,MeCCCH 2], [RP127;CH 2(CH2)2CH2],

[RP128;CH 2(CH2)3CH2], [RP129;CH 2CH2OCH 2CH2], [RP130;H,H] The compound represented by formula (XVIII): [Chem.128]

(wherein R2 1, R22, and R25 are the same as defined above) wherein R2 1, R22, and R25 represent any one combination indicated in the following substituent numbers RQl to RQ45 (hereinafter the compounds of the substituent numbers RQl to RQ45 are referred to as "Present compounds RQl to RQ45", and the "Present compounds RQl to RQ45" are collectively referred to as "Present compound RQ") can be prepared according to the method described in the above processes. The substituent numbers RQl to RQ45 as described herein represent the com binations of R2 1, R22, and R25 in the compound represented by formula (XVIII), and hereinafter are indicated by [substituent number;R 2 1,R22,R25]. For example, the substituent number RQ4 represents the combination wherein R2 1 and R22 are each a hydrogen atom, and R25 is an isopropyl group. For example, the Present compound RQ4 indicates the compound represented by formula (XVIII) wherein the substituent number is RQ4, and indicates the compound represented by formula (XVIII) wherein R2 1 and R22 are each a hydrogen atom, and R: is an isopropyl group as shown in the following. [Chem.129]

[0204] [Substituent number;R ,R ,R25]: [RQl;H,H,Me], [RQ2;H,H,Et], [RQ3;H,H,Pr],

[RQ4;H,H,i-Pr], [RQ5;H,H,c-Pr], [RQ6;H,H,Bu], [RQ7;H,H,t-Bu], [RQ8;H,H,c-PrCH 2

], [RQ9;H,H,Ph], [RQ10;H,H,Bn], [RQ11;H,H,CF 3], [RQ12;H,H,CF 3CH2],

[RQ13;H,H,CF 3CF2], [RQ14;H,H,CF 2H], [RQ15;H,H,CF 2HCH 2], [RQ16;F,H,Me], [RQ17;F,H,Et], [RQ18;F,H,Pr], [RQ19;F,H,i-Pr], [RQ20;F,H,c-Pr], [RQ21;F,H,Bu],

[RQ22;F,H,t-Bu], [RQ23;F,H,c-PrCH 2], [RQ24;F,H,Ph], [RQ25;F,H,Bn],

[RQ26;F,H,CF 3], [RQ27;F,H,CF 3CH ], [RQ28;F,H,CF 3CF ], [RQ29;F,H,CF H],

[RQ30;F,H,CF 2HCH 2], [RQ31;H,F,Me], [RQ32;H,F,Et], [RQ33;H,F,Pr], [RQ34;H,F,i-Pr], [RQ35;H,F,c-Pr], [RQ36;H,F,Bu], [RQ37;H,F,t-Bu],

[RQ38;H,F,c-PrCH 2], [RQ39;H,F,Ph], [RQ40;H,F,Bn], [RQ41;H,F,CF 3],

[RQ42;H,F,CF 3CH ], [RQ43;H,F,CF 3CF ], [RQ44;H,F,CF H], [RQ45;H,F,CF HCH ] [0205] The compound represented by formula (XIX): Chem.130]

(wherein R2 1, R22, and R25 are the same as defined above) wherein R2 1, R22, and R25 represent any one combination indicated in the following substituent numbers RRl to RR45 (hereinafter the compounds of the substituent numbers RRl to RR45 are referred to as "Present compounds RRl to RR45", and the "Present compounds RRl to RR45" are collectively referred to as "Present compound RR") can be prepared according to the method described in the above processes. The substituent numbers RRl to RR45 as described herein represent the com binations of R2 1, R22, and R25 in the compound represented by formula (XIX), and hereinafter are indicated by [substituent number;R 2 1,R22,R25]. For example, the substituent number RR4 represents the combination wherein R2 1 and R22 are each a hydrogen atom, and R25 is an isopropyl group. For example, the Present compound RR4 indicates the compound represented by formula (XIX) wherein the substituent number is RR4, and indicates the compound represented by formula (XIX) wherein R2 1 and R22 are each a hydrogen atom, and R25 is an isopropyl group as shown in the following. [Chem.131]

[0207] [Substituent number;R 1,R ,R25]: [RRl;H,H,Me], [RR2;H,H,Et], [RR3;H,H,Pr],

[RR4;H,H,i-Pr], [RR5;H,H,c-Pr], [RR6;H,H,Bu], [RR7;H,H,t-Bu], [RR8;H,H,c-PrCH 2

], [RR9;H,H,Ph], [RR10;H,H,Bn], [RR11;H,H,CF3], [RR12;H,H,CF3CH2], [RR13;H,H,CF3CF2], [RR14;H,H,CF2H], [RR15;H,H,CF2HCH2], [RR16;F,H,Me], [RR17;F,H,Et], [RR18;F,H,Pr], [RR19;F,H,i-Pr], [RR20;F,H,c-Pr], [RR21;F,H,Bu],

[RR22;F,H,t-Bu], [RR23;F,H,c-PrCH 2], [RR24;F,H,Ph], [RR25;F,H,Bn],

[RR26;F,H,CF3], [RR27;F,H,CF3CH2], [RR28;F,H,CF3CF2], [RR29;F,H,CF2H],

[RR30;F,H,CF2HCH2], [RR31;H,F,Me], [RR32;H,F,Et], [RR33;H,F,Pr], [RR34;H,F,i-Pr], [RR35;H,F,c-Pr], [RR36;H,F,Bu], [RR37;H,F,t-Bu],

[RR38;H,F,c-PrCH 2], [RR39;H,F,Ph], [RR40;H,F,Bn], [RR41;H,F,CF3],

[RR42;H,F,CF3CH2], [RR43;H,F,CF3CF2], [RR44;H,F,CF2H], [RR45;H,F,CF2HCH2] [0208] The compound represented by formula (XX): Chem.132]

[wherein R2 1 and R25 are the same as defined above; and R27 is a hydrogen atom or a fluorine atom] wherein R2 1, R27, and R25 represent any one combination indicated in the following substituent numbers RSI to RS45 (hereinafter the compounds of the substituent numbers RSI to RS45 are referred to as "Present compounds RSI to RS45", and the "Present compounds RSI to RS45" are collectively referred to as "Present compound RS") can be prepared according to the method described in the above processes. The substituent numbers RSI to RS45 as described herein represent the combinations of R2 1, R27, and R25 in the compound represented by formula (XX), and hereinafter are indicated by [substituent number;R 2 1,R2 ,R25]. For example, the substituent number RS4 represents the combination wherein R2 1 and R27 are each a hydrogen atom, and R25 is an isopropyl group. For example, the Present compound RS4 indicates the compound represented by formula (XX) wherein the substituent number is RS4, and indicates the compound rep resented by formula (XX) wherein R2 1 and R27 are each a hydrogen atom, and R25 is an isopropyl group as shown in the following. [Chem.133]

[0210] [Substituent number;R ,R ,R25]: [RSl;H,H,Me], [RS2;H,H,Et], [RS3;H,H,Pr],

[RS4;H,H,i-Pr], [RS5;H,H,c-Pr], [RS6;H,H,Bu], [RS7;H,H,t-Bu], [RS8;H,H,c-PrCH 2],

[RS9;H,H,Ph], [RS10;H,H,Bn], [RS11;H,H,CF 3], [RS12;H,H,CF 3CH2], [RS13;H,H,CF

3CF2], [RS14;H,H,CF 2H], [RS15;H,H,CF 2HCH 2], [RS16;F,H,Me], [RS17;F,H,Et], [RS18;F,H,Pr], [RS19;F,H,i-Pr], [RS20;F,H,c-Pr], [RS21;F,H,Bu], [RS22;F,H,t-Bu],

[RS23;F,H,c-PrCH 2], [RS24;F,H,Ph], [RS25;F,H,Bn], [RS26;F,H,CF 3], [RS27;F,H,CF 3

CH2], [RS28;F,H,CF 3CF2], [RS29;F,H,CF 2H], [RS30;F,H,CF 2HCH 2], [RS31;H,F,Me], [RS32;H,F,Et], [RS33;H,F,Pr], [RS34;H,F,i-Pr], [RS35;H,F,c-Pr], [RS36;H,F,Bu],

[RS37;H,F,t-Bu], [RS38;H,F,c-PrCH 2], [RS39;H,F,Ph], [RS40;H,F,Bn], [RS41;H,F,CF

3], [RS42;H,F,CF 3CH2], [RS43;H,F,CF 3CF2], [RS44;H,F,CF 2H], [RS45;H,F,CF 2HCH 2] [021 1] The compound represented by formula (XXI): [Chem.134] (wherein R2 1, R25, and R27 are the same as defined above) wherein R2 1, R27, and R25 represent any one combination indicated in the following substituent numbers RT1 to RT45 (hereinafter the compounds of the substituent numbers RT1 to RT45 are referred to as "Present compounds RT1 to RT45", and the "Present compounds RT1 to RT45" are collectively referred to as "Present compound RT") can be prepared according to the method described in the above processes. The substituent numbers RT1 to RT45 as described herein represent the combinations of R2 1, R27, and R25 in the compound represented by formula (XXI), and hereinafter are indicated by [substituent number;R 2 1,R2 ,R25]. For example, the substituent number RT4 represents the combination wherein R2 1 and R27 are each a hydrogen atom, and R25 is an isopropyl group. For example, the Present compound RT4 indicates the compound represented by formula (XXI) wherein the substituent number is RT4, and indicates the compound represented by formula (XXI) wherein R2 1 and R27 are each a hydrogen atom, and R25 is an isopropyl group as shown in the following. [Chem.135]

[0213] [Substituent number;R 1,R 7,R25]: [RTl;H,H,Me], [RT2;H,H,Et], [RT3;H,H,Pr],

[RT4;H,H,i-Pr], [RT5;H,H,c-Pr], [RT6;H,H,Bu], [RT7;H,H,t-Bu], [RT8;H,H,c-PrCH2

], [RT9;H,H,Ph], [RT10;H,H,Bn], [RT11;H,H,CF3], [RT12;H,H,CF3CH2],

[RT13;H,H,CF3CF2], [RT14;H,H,CF2H], [RT15;H,H,CF2HCH2], [RT16;F,H,Me], [RT17;F,H,Et], [RT18;F,H,Pr], [RT19;F,H,i-Pr], [RT20;F,H,c-Pr], [RT21;F,H,Bu],

[RT22;F,H,t-Bu], [RT23;F,H,c-PrCH2], [RT24;F,H,Ph], [RT25;F,H,Bn],

[RT26;F,H,CF3], [RT27;F,H,CF3CH2], [RT28;F,H,CF3CF2], [RT29;F,H,CF2H],

[RT30;F,H,CF2HCH2], [RT31;H,F,Me], [RT32;H,F,Et], [RT33;H,F,Pr], [RT34;H,F,i-Pr], [RT35;H,F,c-Pr], [RT36;H,F,Bu], [RT37;H,F,t-Bu],

[RT38;H,F,c-PrCH2], [RT39;H,F,Ph], [RT40;H,F,Bn], [RT41;H,F,CF3], [RT42;H,F,CF

3CH ], [RT43;H,F,CF3CF ], [RT44;H,F,CF H], [RT45;H,F,CF HCH ] [0214] The compound represented by formula (XXII): Chem.136]

(wherein R25 and Q2 1 are the same as defined above) wherein Q2 1 and R25 represent any one combination indicated in the following sub stituent numbers RUl to RU30 (hereinafter the compounds of the substituent numbers RUl to RU30 are referred to as "Present compounds RUl to RU30", and the "Present compounds RUl to RU30" are collectively referred to as "Present compound RU") can be prepared according to the method described in the above processes. The substituent numbers RUl to RU30 as described herein represent the combinations of Q2 1 and R25 in the compound represented by formula (XXII), and hereinafter are indicated by [substituent number;Q 2 1,R25]. For example, the substituent number RU4 represents the combination wherein Q2 1 is an oxygen atom, and R25 is an isopropyl group. For example, the Present compound RU4 indicates the compound represented by formula (XXII) wherein the substituent number is RU4, and indicates the compound represented by formula (XXII) wherein Q2 1 is an oxygen atom, and R25 is an isopropyl group as shown in the following. [Chem.137]

[0216] [Substituent number;Q ,R25]: [RUl;0,Me], [RU2;0,Et], [RU3;0,Pr], [RU4;0,i-Pr],

[RU5;0,c-Pr], [RU6;0,Bu], [RU7;0,t-Bu], [RU8;0,c-PrCH 2], [RU9;0,Ph],

[RU10;O,Bn], [RU11;0,CF 3], [RU12;0,CF 3CH2], [RU13;0,CF 3CF2], [RU14;0,CF 2H],

[RU15;0,CF 2HCH 2], [RU16;NH,Me], [RU17;NH,Et], [RU18;NH,Pr], [RU19;NH,i-Pr], [RU20;NH,c-Pr], [RU21;NH,Bu], [RU22;NH,t-Bu],

[RU23;NH,c-PrCH 2], [RU24;NH,Ph], [RU25;NH,Bn], [RU26;NH,CF 3],

[RU27;NH,CF 3CH2], [RU28;NH,CF 3CF2], [RU29;NH,CF 2H], [RU30;NH,CF 2HCH 2] [0217] The compound represented by formula (XXIII): [Chem.138]

(XX I (wherein R25 and Q2 1 are the same as defined above) wherein Q2 1 and R25 represent any one combination indicated in the following sub stituent numbers RVl to RV30 (hereinafter the compounds of the substituent numbers RVl to RV30 are referred to as "Present compounds RVl to RV30", and the "Present compounds RVl to RV30" are collectively referred to as "Present compound RV") can be prepared according to the method described in the above processes. The substituent numbers RVl to RV30 as described herein represent the combinations of Q2 1 and R25 in the compound represented by formula (XXIII), and hereinafter are indicated by [substituent number;Q 2 1,R25]. For example, the substituent number RV4 represents the combination wherein Q2 1 is an oxygen atom, and R25 is an isopropyl group. For example, the Present compound RV4 indicates the compound represented by formula (XXIII) wherein the substituent number is RV4, and indicates the compound represented by formula (XXIII) wherein Q2 1 is an oxygen atom, and R25 is an isopropyl group as shown in the following. [Chem.139]

[0219] [Substituent number;Q ,R25]: [RVl;0,Me], [RV2;0,Et], [RV3;0,Pr], [RV4;0,i-Pr],

[RV5;0,c-Pr], [RV6;0,Bu], [RV7;0,t-Bu], [RV8;0,c-PrCH 2], [RV9;0,Ph],

[RV10;O,Bn], [RV11;0,CF 3], [RV12;0,CF 3CH2], [RV13;0,CF 3CF2], [RV14;0,CF 2H],

[RV15;0,CF 2HCH 2], [RV16;NH,Me], [RV17;NH,Et], [RV18;NH,Pr], [RV19;NH,i-Pr], [RV20;NH,c-Pr], [RV21;NH,Bu], [RV22;NH,t-Bu],

[RV23;NH,c-PrCH 2], [RV24;NH,Ph], [RV25;NH,Bn], [RV26;NH,CF 3],

[RV27;NH,CF 3CH2], [RV28;NH,CF 3CF2], [RV29;NH,CF 2H], [RV30;NH,CF 2HCH 2] [0220] The compound represented by formula (XXIV): [Chem.140]

(wherein R25 and Q2 1 are the same as defined above) wherein Q2 1 and R25 represent any one combination indicated in the following sub stituent numbers RWl to RW30 (hereinafter the compounds of the substituent numbers RW1 to RW30 are referred to as "Present compounds RW1 to RW30", and the "Present compounds RW1 to RW30" are collectively referred to as "Present compound RW") can be prepared according to the method described in the above processes. The substituent numbers RW1 to RW30 as described herein represent the com binations of Q2 1 and R25 in the compound represented by formula (XXIV), and hereinafter are indicated by [substituent number;Q 2 1,R25]. For example, the substituent number RW4 represents the combination wherein Q2 1 is an oxygen atom, and R25 is an isopropyl group. For example, the Present compound RW4 indicates the compound represented by formula (XXIV) wherein the substituent number is RW4, and indicates the compound represented by formula (XXIV) wherein Q2 1 is an oxygen atom, and R25 is an isopropyl group as shown in the following. [Chem.141]

[0222] [Substituent number;Q ,R25]: [RWl;0,Me], [RW2;0,Et], [RW3;0,Pr],

[RW4;0,i-Pr], [RW5;0,c-Pr], [RW6;0,Bu], [RW7;0,t-Bu], [RW8;0,c-PrCH 2],

[RW9;0,Ph], [RW10;O,Bn], [RW11;0,CF 3], [RW12;0,CF 3CH2], [RW13;0,CF 3CF2],

[RW14;0,CF 2H], [RW15;0,CF 2HCH 2], [RW16;NH,Me], [RW17;NH,Et], [RW18;NH,Pr], [RW19;NH,i-Pr], [RW20;NH,c-Pr], [RW21;NH,Bu],

[RW22;NH,t-Bu], [RW23;NH,c-PrCH 2], [RW24;NH,Ph], [RW25;NH,Bn],

[RW26;NH,CF 3], [RW27;NH,CF 3CH2], [RW28;NH,CF 3CF2], [RW29;NH,CF 2H],

[RW30;NH,CF 2HCH 2] [0223] The compound represented by formula (XXV): [Chem.142]

(wherein R25 and Q2 1 are the same as defined above) wherein Q2 1 and R25 represent any one combination indicated in the following sub stituent numbers RXl to RX30 (hereinafter the compounds of the substituent numbers RXl to RX30 are referred to as "Present compounds RXl to RX30", and the "Present compounds RXl to RX30" are collectively referred to as "Present compound RX") can be prepared according to the method described in the above processes. The substituent numbers RXl to RX30 as described herein represent the combinations of Q2 1 and R25 in the compound represented by formula (XXV), and hereinafter are indicated by [substituent number;Q2 1,R25]. For example, the substituent number RX4 represents the combination wherein Q2 1 is an oxygen atom, and R25 is an isopropyl group. For example, the Present compound RX4 indicates the compound represented by formula (XXV) wherein the substituent number is RX4, and indicates the compound represented by formula (XXV) wherein Q2 1 is an oxygen atom, and R23 is an isopropyl group as shown in the following. [Chem.143]

[0225] [Substituent number;Q 1,R25]: [RXl;0,Me], [RX2;0,Et], [RX3;0,Pr], [RX4;0,i-Pr],

[RX5;0,c-Pr], [RX6;0,Bu], [RX7;0,t-Bu], [RX8;0,c-PrCH 2], [RX9;0,Ph],

[RX10;O,Bn], [RX11;0,CF 3], [RX12;0,CF 3CH2], [RX13;0,CF 3CF2], [RX14;0,CF 2H],

[RX15;0,CF 2HCH2], [RX16;NH,Me], [RX17;NH,Et], [RX18;NH,Pr], [RX19;NH,i-Pr], [RX20;NH,c-Pr], [RX21;NH,Bu], [RX22;NH,t-Bu],

[RX23;NH,c-PrCH2], [RX24;NH,Ph], [RX25;NH,Bn], [RX26;NH,CF3],

[RX27;NH,CF3CH2], [RX28;NH,CF3CF2], [RX29;NH,CF2H], [RX30;NH,CF2HCH2] [0226] The compound represented by formula (XXVI): [Chem.144]

(wherein R3 1, R32, and R33 are the same as defined above) wherein R3 1, R32, and R33 represent any one combination indicated in the following substituent numbers RYl to RYl 550 (hereinafter the compounds of the substituent numbers RYl to RYl 550 are referred to as "Present compounds RYl to RYl 550", and the "Present compounds RYl to RYl 550" are collectively referred to as "Present compound RY") can be prepared according to the method described in the above processes. The substituent numbers RYl to RYl 550 as described herein represent the combinations of R3 1, R32, and R33 in the compound represented by formula (XXVI), and hereinafter are indicated by [substituent number;R 1,R 2,R33]. For example, the substituent number RY4 represents the combination wherein R3 1 is a hydrogen atom, R32 is a hydrogen atom, and R33 is an isopropyl group. For example, the Present compound RY4 indicates the compound represented by formula (XXVI) wherein the substituent number is RX4, and indicates the compound represented by formula (XXVI) wherein R3 1 is a hydrogen atom, R32 is a hydrogen atom, and R33 is an isopropyl group as shown in the following. [Chem.145]

[Substituent number;R ,R ,R33]: [RYl;H,H,Me], [RY2;H,H,Et], [RY3;H,H,Pr], [RY4;H,H,i-Pr], [RY5;H,H,c-Pr], [RY6;H,H,t-Bu], [RY7;H,H,Bu], [RY8;H,H,t-Bu],

[RY9;H,H,c-PrCH2], [RY10;H,H,Ph], [RYll;H,H,Bn], [RY12;H,H,CF3],

[RY13;H,H,CF3CH2], [RY14;H,H,CF3CF2], [RY15;H,H,CF2H], [RY16;H,H,CF2HCH2 ], [RY17;Me,H,Me], [RY18;Me,H,Et], [RY19;Me,H,Pr], [RY20;Me,H,i-Pr], [RY21;Me,H,c-Pr], [RY22;Me,H,t-Bu], [RY23;Me,H,Bu], [RY24;Me,H,t-Bu],

[RY25;Me,H,c-PrCH2], [RY26;Me,H,Ph], [RY27;Me,H,Bn], [RY28;Me,H,CF3],

[RY29;Me,H,CF3CH2], [RY30;Me,H,CF3CF2], [RY31;Me,H,CF2H], [RY32;Me,H,CF2

HCH2], [RY33;Et,H,Me], [RY34;Et,H,Et], [RY35;Et,H,Pr], [RY36;Et,H,i-Pr], [RY37;Et,H,c-Pr], [RY38;Et,H,t-Bu], [RY39;Et,H,Bu], [RY40;Et,H,t-Bu],

[RY41;Et,H,c-PrCH2], [RY42;Et,H,Ph], [RY43;Et,H,Bn], [RY44;Et,H,CF3], [RY45;Et,H,CF3CH2], [RY46;Et,H,CF3CF2], [RY47;Et,H,CF2H], [RY48;Et,H,CF2

HCH2], [RY49;Pr,H,Me], [RY50;Pr,H,Et], [RY51;Pr,H,Pr], [RY52;Pr,H,i-Pr], [RY53;Pr,H,c-Pr], [RY54;Pr,H,t-Bu], [RY55;Pr,H,Bu], [RY56;Pr,H,t-Bu],

[RY57;Pr,H,c-PrCH2], [RY58;Pr,H,Ph], [RY59;Pr,H,Bn], [RY60;Pr,H,CF3],

[RY61;Pr,H,CF3CH2], [RY62;Pr,H,CF3CF2], [RY63;Pr,H,CF2H], [RY64;Pr,H,CF2

HCH2], [RY65;i-Pr,H,Me], [RY66;i-Pr,H,Et], [RY67;i-Pr,H,Pr], [RY68;i-Pr,H,i-Pr], [RY69;i-Pr,H,c-Pr], [RY70;i-Pr,H,t-Bu], [RY71;i-Pr,H,Bu], [RY72;i-Pr,H,t-Bu],

[RY73;i-Pr,H,c-PrCH2], [RY74;i-Pr,H,Ph], [RY75;i-Pr,H,Bn], [RY76;i-Pr,H,CF3],

[RY77;i-Pr,H,CF3CH2], [RY78;i-Pr,H,CF3CF2], [RY79;i-Pr,H,CF2H],

[RY80;i-Pr,H,CF2HCH2], [RY81;c-Pr,H,Me], [RY82;c-Pr,H,Et], [RY83;c-Pr,H,Pr], [RY84;c-Pr,H,i-Pr], [RY85;c-Pr,H,c-Pr], [RY86;c-Pr,H,t-Bu], [RY87;c-Pr,H,Bu], [RY88;c-Pr,H,t-Bu], [RY89;c-Pr,H,c-PrCH 2], [RY90;c-Pr,H,Ph], [RY91;c-Pr,H,Bn],

[RY92;c-Pr,H,CF 3], [RY93;c-Pr,H,CF 3CH2], [RY94;c-Pr,H,CF 3CF2],

[RY95;c-Pr,H,CF 2H], [RY96;c-Pr,H,CF 2HCH2], [RY97;c-PrCH 2,H,Me],

[RY98;c-PrCH 2,H,Et], [RY99;c-PrCH 2,H,Pr], [RY100;c-PrCH 2,H,i-Pr],

[RY101;c-PrCH2,H,c-Pr] , [RY102;c-PrCH 2,H,t-Bu], [RY103;c-PrCH2,H,Bu] ,

[RY104;c-PrCH 2,H,t-Bu] , [RY105;c-PrCH2,H,c-PrCH2], [RY106;c-PrCH2,H,Ph],

[RY107;c-PrCH2,H,Bn], [RY108;c-PrCH2,H,CF3], [RY109;c-PrCH2,H,CF3CH2],

[RYl 10;c-PrCH2,H,CF3CF2], [RYl 1l;c-PrCH 2,H,CF2H], [RYl 12;c-PrCH2,H,CF2HCH

2], [RY113;i-Bu,H,Me], [RY114;i-Bu,H,Et], [RY115;i-Bu,H,Pr], [RY116;i-Bu,H,i-Pr], [RY117;i-Bu,H,c-Pr], [RY118;i-Bu,H,t-Bu], [RY119;i-Bu,H,Bu],

[RY120;i-Bu,H,t-Bu], [RY121;i-Bu,H,c-PrCH 2], [RY122;i-Bu,H,Ph],

[RY123;i-Bu,H,Bn], [RY124;i-Bu,H,CF 3], [RY125;i-Bu,H,CF 3CH2],

[RY126;i-Bu,H,CF 3CF2], [RY127;i-Bu,H,CF 2H], [RY128;i-Bu,H,CF 2HCH2],

[RY129;CF3CH2,H,Me], [RY130;CF3CH2,H,Et], [RY131;CF3CH2,H,Pr], [RY132;CF3

CH2,H,i-Pr], [RY133;CF3CH2,H,c-Pr], [RY134;CF3CH2,H,t-Bu], [RY135;CF3CH2

,H,Bu], [RY136;CF3CH2,H,t-Bu], [RY137;CF3CH2,H,c-PrCH2], [RY138;CF3CH2

,H,Ph], [RY139;CF3CH2,H,Bn], [RY140;CF3CH2,H,CF3], [RY141;CF3CH2,H,CF3CH2],

[RY142;CF3CH2,H,CF3CF2], [RY143;CF3CH2,H,CF2H], [RY144;CF3CH2,H,CF2HCH2

], [RY145;CF2HCH2,Me,Me], [RY146;CF2HCH2,H,Et], [RY147;CF2HCH2,H,Pr],

[RY148;CF2HCH2,H,i-Pr], [RY149;CF2HCH2,H,c-Pr], [RY150;CF2HCH2,H,t-Bu],

[RY151;CF2HCH2,H,Bu] , [RY152;CF2HCH2,H,t-Bu] , [RY153;CF2HCH2,H,c-PrCH2],

[RY154;CF2HCH2,H,Ph], [RY155;CF2HCH2,H,Bn] , [RY156;CF2HCH2,H,CF3],

[RY157;CF2HCH2,H,CF3CH2], [RY158;CF2HCH2,H,CF3CF2], [RY159;CF2HCH2

,H,CF2H], [RY160;CF2HCH2,H,CF2HCH2], [RY161;MeOCH 2,H,Me],

[RY162;MeOCH 2,H,Et] , [RY163;MeOCH2,H,Pr], [RY164;MeOCH 2,H,i-Pr] ,

[RY165;MeOCH2,H,c-Pr] , [RY166;MeOCH2,H,t-Bu], [RY167;MeOCH2,H,Bu] ,

[RY168;MeOCH2,H,t-Bu], [RY169;MeOCH2,H,c-PrCH2], [RY170;MeOCH 2,H,Ph] ,

[RY171;MeOCH2,H,Bn] , [RY172;MeOCH 2,H,CF3], [RY173;MeOCH2,H,CF3CH2],

[RY174;MeOCH 2,H,CF3CF2], [RY175;MeOCH 2,H,CF2H], [RY176;MeOCH 2,H,CF2

HCH2], [RY177;EtOCH 2,H,Me], [RY178;EtOCH 2,H,Et], [RY179;EtOCH 2,H,Pr],

[RY180;EtOCH2,H,i-Pr] , [RY181;EtOCH2,H,c-Pr] , [RY182;EtOCH2,H,t-Bu],

[RY183;EtOCH2,H,Bu] , [RY184;EtOCH2,H,t-Bu] , [RY185;EtOCH2,H,c-PrCH2],

[RY186;EtOCH 2,H,Ph], [RY187;EtOCH 2,H,Bn], [RY188;EtOCH 2,H,CF3],

[RY189;EtOCH2,H,CF3CH2], [RY190;EtOCH 2,H,CF3CF2], [RY191;EtOCH2,H,CF2H],

[RY192;EtOCH 2,H,CF2HCH2], [RY193;MeSCH2,H,Me] , [RY194;MeSCH 2,H,Et],

[RY195;MeSCH2,H,Pr], [RY196;MeSCH2,H,i-Pr] , [RY197;MeSCH2,H,c-Pr] ,

[RY198;MeSCH 2,H,t-Bu], [RY199;MeSCH 2,H,Bu], [RY200;MeSCH 2,H,t-Bu],

[RY201;MeSCH2,H,c-PrCH2], [RY202;MeSCH 2,H,Ph] , [RY203;MeSCH2,H,Bn] , [RY204;MeSCH 2,H,CF3], [RY205;MeSCH2,H,CF3CH2], [RY206;MeSCH2,H,CF3CF2],

[RY207;MeSCH2,H,CF2H], [RY208;MeSCH2,H,CF2HCH2], [RY209;EtSCH2,H,Me],

[RY210;EtSCH 2,H,Et], [RY21 l;EtSCH 2,H,Pr], [RY212;EtSCH2,H,i-Pr],

[RY213;EtSCH2,H,c-Pr] , [RY214;EtSCH2,H,t-Bu], [RY215;EtSCH2,H,Bu] ,

[RY216;EtSCH2,H,t-Bu] , [RY217;EtSCH2,H,c-PrCH2], [RY218;EtSCH2,H,Ph],

[RY219;EtSCH2,H,Bn], [RY220;EtSCH2,H,CF3], [RY221;EtSCH2,H,CF3CH2],

[RY222;EtSCH 2,H,CF3CF2], [RY223;EtSCH2,H,CF2H], [RY224;EtSCH 2,H,CF2HCH2], [RY225;Ph,H,Me], [RY226;Ph,H,Et], [RY227;Ph,H,Pr], [RY228;Ph,H,i-Pr], [RY229;Ph,H,c-Pr], [RY230;Ph,H,t-Bu], [RY231;Ph,H,Bu], [RY232;Ph,H,t-Bu],

[RY233;Ph,H,c-PrCH 2], [RY234;Ph,H,Ph], [RY235;Ph,H,Bn], [RY236;Ph,H,CF 3],

[RY237;Ph,H,CF 3CH2], [RY238;Ph,H,CF 3CF2], [RY239;Ph,H,CF2H],

[RY240;Ph,H,CF 2HCH2], [RY241;Bn,H,Me] , [RY242;Bn,H,Et] , [RY243;Bn,H,Pr], [RY244;Bn,H,i-Pr], [RY245;Bn,H,c-Pr], [RY246;Bn,H,t-Bu], [RY247;Bn,H,Bu],

[RY248;Bn,H,t-Bu], [RY249;Bn,H,c-PrCH 2], [RY250;Bn,H,Ph], [RY251;Bn,H,Bn],

[RY252;Bn,H,CF 3], [RY253;Bn,H,CF 3CH2], [RY254;Bn,H,CF 3CF2],

[RY255;Bn,H,CF 2H], [RY256;Bn,H,CF 2HCH2], [RY257;HCCCH 2,H,Me],

[RY258;HCCCH 2,H,Et], [RY259;HCCCH 2,H,Pr], [RY260;HCCCH 2,H,i-Pr],

[RY261;HCCCH2,H,c-Pr] , [RY262;HCCCH2,H,t-Bu], [RY263;HCCCH2,H,Bu] ,

[RY264;HCCCH 2,H,t-Bu], [RY265;HCCCH 2,H,c-PrCH2], [RY266;HCCCH 2,H,Ph],

[RY267;HCCCH2,H,Bn] , [RY268;HCCCH2,H,CF3], [RY269;HCCCH2,H,CF3CH2],

[RY270;HCCCH 2,H,CF3CF2], [RY271;HCCCH2,H,CF2H], [RY272;HCCCH 2,H,CF2

HCH2], [RY273;CH3CCCH2,H,Me], [RY274;CH3CCCH2,H,Et], [RY275;CH3CCCH2

,H,Pr], [RY276;CH3CCCH2,H,i-Pr], [RY277;CH3CCCH2,H,c-Pr], [RY278;CH3CCCH2

,H,t-Bu], [RY279;CH3CCCH2,H,Bu], [RY280;CH3CCCH2,H,t-Bu], [RY281;CH3

CCCH2,H,c-PrCH2], [RY282;CH3CCCH2,H,Ph], [RY283;CH3CCCH2,H,Bn],

[RY284;CH3CCCH ,H,CF3], [RY285;CH3CCCH ,H,CF3CH ], [RY286;CH3CCCH

,H,CF3CF2], [RY287;CH3CCCH2,H,CF2H], [RY288;CH3CCCH2,H,CF2HCH2], [RY289;H,Me,Me], [RY290;H,Me,Et], [RY291;H,Me,Pr], [RY292;H,Me,i-Pr], [RY293;H,Me,c-Pr], [RY294;H,Me,t-Bu], [RY295;H,Me,Bu], [RY296;H,Me,t-Bu],

[RY297;H,Me,c-PrCH 2], [RY298;H,Me,Ph], [RY299;H,Me,Bn], [RY300;H,Me,CF 3],

[RY301;H,Me,CF 3CH2], [RY302;H,Me,CF 3CF2], [RY303;H,Me,CF 2H],

[RY304;H,Me,CF 2HCH2], [RY305;Me,Me,Me] , [RY306;Me,Me,Et], [RY307;Me,Me,Pr], [RY308;Me,Me,i-Pr], [RY309;Me,Me,c-Pr], [RY310;Me,Me,t-Bu], [RY311;Me,Me,Bu], [RY312;Me,Me,t-Bu],

[RY313;Me,Me,c-PrCH 2], [RY314;Me,Me,Ph], [RY315;Me,Me,Bn] ,

[RY316;Me,Me,CF 3], [RY317;Me,Me,CF 3CH2], [RY318;Me,Me,CF 3CF2],

[RY319;Me,Me,CF 2H], [RY320;Me,Me,CF 2HCH2], [RY321;Et,Me,Me] , [RY322;Et,Me,Et] , [RY323;Et,Me,Pr], [RY324;Et,Me,i-Pr], [RY325;Et,Me,c-Pr], [RY326;Et,Me,t-Bu], [RY327;Et,Me,Bu], [RY328;Et,Me,t-Bu],

[RY329;Et,Me,c-PrCH 2], [RY330;Et,Me,Ph], [RY331;Et,Me,Bn], [RY332;Et,Me,CF3

], [RY333;Et,Me,CF3CH2], [RY334;Et,Me,CF3CF2], [RY335;Et,Me,CF2H],

[RY336;Et,Me,CF2HCH2], [RY337;Pr,Me,Me], [RY338;Pr,Me,Et], [RY339;Pr,Me,Pr], [RY340;Pr,Me,i-Pr], [RY341;Pr,Me,c-Pr], [RY342;Pr,Me,t-Bu], [RY343;Pr,Me,Bu],

[RY344;Pr,Me,t-Bu], [RY345;Pr,Me,c-PrCH 2], [RY346;Pr,Me,Ph],

[RY347;Pr,Me,Bn], [RY348;Pr,Me,CF3], [RY349;Pr,Me,CF3CH2], [RY350;Pr,Me,CF3

CF2], [RY351;Pr,Me,CF2H], [RY352;Pr,Me,CF2HCH2], [RY353;i-Pr,Me,Me], [RY354;i-Pr,Me,Et], [RY355;i-Pr,Me,Pr], [RY356;i-Pr,Me,i-Pr], [RY357;i-Pr,Me,c-Pr], [RY358;i-Pr,Me,t-Bu], [RY359;i-Pr,Me,Bu],

[RY360;i-Pr,Me,t-Bu] , [RY361;i-Pr,Me,c-PrCH2], [RY362;i-Pr,Me,Ph],

[RY363;i-Pr,Me,Bn], [RY364;i-Pr,Me,CF 3], [RY365;i-Pr,Me,CF3CH2],

[RY366;i-Pr,Me,CF 3CF2], [RY367;i-Pr,Me,CF 2H], [RY368;i-Pr,Me,CF2HCH2], [RY369;c-Pr,Me,Me], [RY370;c-Pr,Me,Et], [RY371;c-Pr,Me,Pr], [RY372;c-Pr,Me,i-Pr], [RY373;c-Pr,Me,c-Pr], [RY374;c-Pr,Me,t-Bu],

[RY375;c-Pr,Me,Bu], [RY376;c-Pr,Me,t-Bu], [RY377;c-Pr,Me,c-PrCH 2],

[RY378;c-Pr,Me,Ph], [RY379;c-Pr,Me,Bn], [RY380;c-Pr,Me,CF3],

[RY381;c-Pr,Me,CF 3CH2], [RY382;c-Pr,Me,CF 3CF2], [RY383;c-Pr,Me,CF 2H],

[RY384;c-Pr,Me,CF 2HCH2], [RY385;c-PrCH2,Me,Me], [RY386;c-PrCH2,Me,Et],

[RY387;c-PrCH2,Me,Pr], [RY388;c-PrCH2,Me,i-Pr], [RY389;c-PrCH2,Me,c-Pr],

[RY390;c-PrCH2,Me,t-Bu], [RY391;c-PrCH2,Me,Bu], [RY392;c-PrCH2,Me,t-Bu],

[RY393;c-PrCH2,Me,c-PrCH2], [RY394;c-PrCH2,Me,Ph], [RY395;c-PrCH2,Me,Bn],

[RY396;c-PrCH2,Me,CF3], [RY397;c-PrCH2,Me,CF3CH2], [RY398;c-PrCH2,Me,CF3

CF2], [RY399;c-PrCH2,Me,CF2H], [RY400;c-PrCH2,Me,CF2HCH2], [RY401;i-Bu,Me,Me], [RY402;i-Bu,Me,Et], [RY403;i-Bu,Me,Pr], [RY404;i-Bu,Me,i-Pr] , [RY405;i-Bu,Me,c-Pr] , [RY406;i-Bu,Me,t-Bu] ,

[RY407;i-Bu,Me,Bu], [RY408;i-Bu,Me,t-Bu], [RY409;i-Bu,Me,c-PrCH 2],

[RY410;i-Bu,Me,Ph], [RY411;i-Bu,Me,Bn], [RY412;i-Bu,Me,CF3],

[RY413;i-Bu,Me,CF3CH2], [RY414;i-Bu,Me,CF3CF2], [RY415;i-Bu,Me,CF2H],

[RY416;i-Bu,Me,CF2HCH2], [RY417;CF3CH2,Me,Me] , [RY418;CF3CH2,Me,Et] ,

[RY419;CF3CH2,Me,Pr], [RY420;CF3CH2,Me,i-Pr] , [RY421;CF3CH2,Me,c-Pr],

[RY422;CF3CH2,Me,t-Bu] , [RY423;CF3CH2,Me,Bu] , [RY424;CF3CH2,Me,t-Bu] ,

[RY425;CF3CH2,Me,c-PrCH2], [RY426;CF3CH2,Me,Ph], [RY427;CF3CH2,Me,Bn] ,

[RY428;CF3CH2,Me,CF3], [RY429;CF3CH2,Me,CF3CH2], [RY430;CF3CH2,Me,CF3CF2

1, [RY431;CF3CH2,Me,CF2H], [RY432;CF3CH2,Me,CF2HCH2], [RY433;CF2HCH2

,Me,Me], [RY434;CF2HCH2,Me,Et], [RY435;CF2HCH2,Me,Pr], [RY436;CF2HCH2

,Me,i-Pr], [RY437;CF2HCH2,Me,c-Pr], [RY438;CF2HCH2,Me,t-Bu], [RY439;CF2HCH

2,Me,Bu], [RY440;CF2HCH2,Me,t-Bu], [RY441;CF2HCH2,Me,c-PrCH2], [RY442;CF2 HCH2,Me,Ph], [RY443;CF2HCH2,Me,Bn], [RY444;CF2HCH2,Me,CF3], [RY445;CF2

HCH2,Me,CF3CH2], [RY446;CF2HCH2,Me,CF3CF2], [RY447;CF2HCH2,Me,CF2H],

[RY448;CF2HCH2,Me,CF2HCH2], [RY449;MeOCH2,Me,Me], [RY450;MeOCH2

,Me,Et], [RY451;MeOCH2,Me,Pr], [RY452;MeOCH2,Me,i-Pr], [RY453;MeOCH2

,Me,c-Pr], [RY454;MeOCH2,Me,t-Bu], [RY455;MeOCH2,Me,Bu], [RY456;MeOCH2

,Me,t-Bu], [RY457;MeOCH2,Me,c-PrCH2], [RY458;MeOCH2,Me,Ph],

[RY459;MeOCH2,Me,Bn], [RY460;MeOCH2,Me,CF3], [RY461;MeOCH2,Me,CF3CH2

], [RY462;MeOCH2,Me,CF3CF2], [RY463;MeOCH2,Me,CF2H], [RY464;MeOCH2

,Me,CF2HCH2], [RY465;EtOCH2,Me,Me], [RY466;EtOCH2,Me,Et], [RY467;EtOCH2

,Me,Pr], [RY468;EtOCH2,Me,i-Pr], [RY469;EtOCH2,Me,c-Pr], [RY470;EtOCH2

,Me,t-Bu], [RY471;EtOCH2,Me,Bu], [RY472;EtOCH2,Me,t-Bu], [RY473;EtOCH2

,Me,c-PrCH2], [RY474;EtOCH2,Me,Ph], [RY475;EtOCH2,Me,Bn], [RY476;EtOCH2

,Me,CF3], [RY477;EtOCH2,Me,CF3CH2], [RY478;EtOCH2,Me,CF3CF2],

[RY479;EtOCH2,Me,CF2H], [RY480;EtOCH2,Me,CF2HCH2], [RY481;MeSCH2

,Me,Me], [RY482;MeSCH2,Me,Et], [RY483;MeSCH2,Me,Pr], [RY484;MeSCH2

,Me,i-Pr], [RY485;MeSCH2,Me,c-Pr], [RY486;MeSCH2,Me,t-Bu], [RY487;MeSCH2

,Me,Bu], [RY488;MeSCH2,Me,t-Bu], [RY489;MeSCH2,Me,c-PrCH2],

[RY490;MeSCH2,Me,Ph], [RY491;MeSCH2,Me,Bn] , [RY492;MeSCH2,Me,CF3],

[RY493;MeSCH2,Me,CF3CH2], [RY494;MeSCH2,Me,CF3CF2], [RY495;MeSCH2

,Me,CF2H], [RY496;MeSCH2,Me,CF2HCH2], [RY497;EtSCH2,Me,Me],

[RY498;EtSCH2,Me,Et], [RY499;EtSCH2,Me,Pr], [RY500;EtSCH2,Me,i-Pr],

[RY501;EtSCH2,Me,c-Pr] , [RY502;EtSCH2,Me,t-Bu], [RY503;EtSCH2,Me,Bu] ,

[RY504;EtSCH2,Me,t-Bu], [RY505;EtSCH2,Me,c-PrCH2], [RY506;EtSCH2,Me,Ph],

[RY507;EtSCH2,Me,Bn] , [RY508;EtSCH2,Me,CF3], [RY509;EtSCH2,Me,CF3CH2],

[RY510;EtSCH2,Me,CF3CF2], [RY51 l;EtSCH 2,Me,CF2H], [RY512;EtSCH2,Me,CF2

HCH2], [RY513;Ph,Me,Me], [RY514;Ph,Me,Et], [RY515;Ph,Me,Pr], [RY516;Ph,Me,i-Pr], [RY517;Ph,Me,c-Pr], [RY518;Ph,Me,t-Bu], [RY519;Ph,Me,Bu],

[RY520;Ph,Me,t-Bu], [RY521;Ph,Me,c-PrCH 2], [RY522;Ph,Me,Ph],

[RY523;Ph,Me,Bn], [RY524;Ph,Me,CF 3], [RY525;Ph,Me,CF3CH2],

[RY526;Ph,Me,CF3CF2], [RY527;Ph,Me,CF2H], [RY528;Ph,Me,CF2HCH2], [RY529;Bn,Me,Me], [RY530;Bn,Me,Et] , [RY531;Bn,Me,Pr], [RY532;Bn,Me,i-Pr], [RY533;Bn,Me,c-Pr], [RY534;Bn,Me,t-Bu], [RY535;Bn,Me,Bu],

[RY536;Bn,Me,t-Bu], [RY537;Bn,Me,c-PrCH 2], [RY538;Bn,Me,Ph],

[RY539;Bn,Me,Bn], [RY540;Bn,Me,CF 3], [RY541;Bn,Me,CF 3CH2],

[RY542;Bn,Me,CF 3CF2], [RY543;Bn,Me,CF2H], [RY544;Bn,Me,CF 2HCH2],

[RY545;HCCCH2,Me,Me] , [RY546;HCCCH2,Me,Et], [RY547;HCCCH2,Me,Pr],

[RY548;HCCCH2,Me,i-Pr], [RY549;HCCCH2,Me,c-Pr], [RY550;HCCCH2,Me,t-Bu],

[RY551;HCCCH2,Me,Bu], [RY552;HCCCH2,Me,t-Bu], [RY553;HCCCH2,Me,c-PrCH 2], [RY554;HCCCH2,Me,Ph], [RY555;HCCCH2,Me,Bn], [RY556;HCCCH2,Me,CF3],

[RY557;HCCCH2,Me,CF3CH2], [RY558;HCCCH2,Me,CF3CF2], [RY559;HCCCH2

,Me,CF2H], [RY560;HCCCH2,Me,CF2HCH2], [RY561;CH3CCCH2,Me,Me],

[RY562;CH3CCCH2,Me,Et], [RY563;CH3CCCH2,Me,Pr], [RY564;CH3CCCH2

,Me,i-Pr], [RY565;CH3CCCH2,Me,c-Pr], [RY566;CH3CCCH2,Me,t-Bu], [RY567;CH3

CCCH2,Me,Bu], [RY568;CH3CCCH2,Me,t-Bu], [RY569;CH3CCCH2,Me,c-PrCH2],

[RY570;CH3CCCH2,Me,Ph], [RY571;CH3CCCH2,Me,Bn], [RY572;CH3CCCH2

,Me,CF3], [RY573;CH3CCCH2,Me,CF3CH2], [RY574;CH3CCCH2,Me,CF3CF2],

[RY575;CH3CCCH2,Me,CF2H], [RY576;CH3CCCH2,Me,CF2HCH2], [RY577;H,Et,Et] , [RY578;H,Et,Pr], [RY579;H,Et,i-Pr], [RY580;H,Et,c-Pr], [RY581;H,Et,t-Bu],

[RY582;H,Et,Bu], [RY583;H,Et,t-Bu], [RY584;H,Et,c-PrCH 2], [RY585;H,Et,Ph],

[RY586;H,Et,Bn], [RY587;H,Et,CF3], [RY588;H,Et,CF3CH2], [RY589;H,Et,CF3CF2],

[RY590;H,Et,CF2H], [RY591;H,Et,CF2HCH2], [RY592;Me,Et,Et] , [RY593;Me,Et,Pr], [RY594;Me,Et,i-Pr], [RY595;Me,Et,c-Pr], [RY596;Me,Et,t-Bu], [RY597;Me,Et,Bu],

[RY598;Me,Et,t-Bu], [RY599;Me,Et,c-PrCH 2], [RY600;Me,Et,Ph],

[RY601;Me,Et,Bn], [RY602;Me,Et,CF3], [RY603;Me,Et,CF3CH2],

[RY604;Me,Et,CF3CF2], [RY605;Me,Et,CF2H], [RY606;Me,Et,CF2HCH2], [RY607;Et,Et,Et], [RY608;Et,Et,Pr], [RY609;Et,Et,i-Pr], [RY610;Et,Et,c-Pr],

[RY611;Et,Et,t-Bu], [RY612;Et,Et,Bu], [RY613;Et,Et,t-Bu], [RY614;Et,Et,c-PrCH 2],

[RY615;Et,Et,Ph], [RY616;Et,Et,Bn], [RY617;Et,Et,CF3], [RY618;Et,Et,CF3CH2],

[RY619;Et,Et,CF3CF2], [RY620;Et,Et,CF2H], [RY621;Et,Et,CF2HCH2], [RY622;Pr,Et,Et], [RY623;Pr,Et,Pr], [RY624;Pr,Et,i-Pr], [RY625;Pr,Et,c-Pr],

[RY626;Pr,Et,t-Bu], [RY627;Pr,Et,Bu], [RY628;Pr,Et,t-Bu], [RY629;Pr,Et,c-PrCH 2],

[RY630;Pr,Et,Ph], [RY631;Pr,Et,Bn], [RY632;Pr,Et,CF3], [RY633;Pr,Et,CF3CH2],

[RY634;Pr,Et,CF3CF2], [RY635;Pr,Et,CF2H], [RY636;Pr,Et,CF2HCH2], [RY637;i-Pr,Et,Et], [RY638;i-Pr,Et,Pr], [RY639;i-Pr,Et,i-Pr], [RY640;i-Pr,Et,c-Pr], [RY641;i-Pr,Et,t-Bu], [RY642;i-Pr,Et,Bu], [RY643;i-Pr,Et,t-Bu],

[RY644;i-Pr,Et,c-PrCH 2], [RY645;i-Pr,Et,Ph], [RY646;i-Pr,Et,Bn], [RY647;i-Pr,Et,CF

3], [RY648;i-Pr,Et,CF3CH2], [RY649;i-Pr,Et,CF3CF2], [RY650;i-Pr,Et,CF2H],

[RY651;i-Pr,Et,CF2HCH2], [RY652;c-Pr,Et,Et], [RY653;c-Pr,Et,Pr], [RY654;c-Pr,Et,i-Pr] , [RY655;c-Pr,Et,c-Pr], [RY656;c-Pr,Et,t-Bu] ,

[RY657;c-Pr,Et,Bu], [RY658;c-Pr,Et,t-Bu], [RY659;c-Pr,Et,c-PrCH 2],

[RY660;c-Pr,Et,Ph], [RY661;c-Pr,Et,Bn], [RY662;c-Pr,Et,CF3], [RY663;c-Pr,Et,CF3

CH2], [RY664;c-Pr,Et,CF3CF2], [RY665;c-Pr,Et,CF2H], [RY666;c-Pr,Et,CF2HCH2],

[RY667;c-PrCH2,Et,Et], [RY668;c-PrCH2,Et,Pr], [RY669;c-PrCH2,Et,i-Pr],

[RY670;c-PrCH2,Et,c-Pr], [RY671;c-PrCH2,Et,t-Bu] , [RY672;c-PrCH2,Et,Bu] ,

[RY673;c-PrCH2,Et,t-Bu], [RY674;c-PrCH2,Et,c-PrCH2], [RY675;c-PrCH2,Et,Ph],

[RY676;c-PrCH2,Et,Bn], [RY677;c-PrCH2,Et,CF3], [RY678;c-PrCH2,Et,CF3CH2], [RY679;c-PrCH 2,Et,CF3CF2], [RY680;c-PrCH 2,Et,CF2H], [RY681;c-PrCH2,Et,CF2

HCH2], [RY682;i-Bu,Et,Et], [RY683;i-Bu,Et,Pr], [RY684;i-Bu,Et,i-Pr], [RY685;i-Bu,Et,c-Pr], [RY686;i-Bu,Et,t-Bu], [RY687;i-Bu,Et,Bu],

[RY688;i-Bu,Et,t-Bu], [RY689;i-Bu,Et,c-PrCH 2], [RY690;i-Bu,Et,Ph],

[RY691;i-Bu,Et,Bn], [RY692;i-Bu,Et,CF 3], [RY693;i-Bu,Et,CF3CH2],

[RY694;i-Bu,Et,CF 3CF2], [RY695;i-Bu,Et,CF 2H], [RY696;i-Bu,Et,CF 2HCH2],

[RY697;CF3CH2,Et,Et], [RY698;CF3CH2,Et,Pr], [RY699;CF3CH2,Et,i-Pr], [RY700;CF

3CH2,Et,c-Pr], [RY701;CF3CH2,Et,t-Bu], [RY702;CF3CH2,Et,Bu], [RY703;CF3CH2

,Et,t-Bu], [RY704;CF3CH2,Et,c-PrCH2], [RY705;CF3CH2,Et,Ph], [RY706;CF3CH2

,Et,Bn], [RY707;CF3CH2,Et,CF3], [RY708;CF3CH2,Et,CF3CH2], [RY709;CF3CH2

,Et,CF3CF2], [RY710;CF3CH2,Et,CF2H], [RY711;CF3CH2,Et,CF2HCH2], [RY712;CF2

HCH2,Et,Et], [RY713;CF2HCH2,Et,Pr], [RY714;CF2HCH2,Et,i-Pr], [RY715;CF2HCH2

,Et,c-Pr], [RY716;CF2HCH2,Et,t-Bu], [RY717;CF2HCH2,Et,Bu], [RY718;CF2HCH2

,Et,t-Bu], [RY719;CF2HCH2,Et,c-PrCH2], [RY720;CF2HCH2,Et,Ph], [RY721;CF2HCH

2,Et,Bn], [RY722;CF2HCH2,Et,CF3], [RY723;CF2HCH2,Et,CF3CH2], [RY724;CF2HCH

2,Et,CF3CF2], [RY725;CF2HCH2,Et,CF2H], [RY726;CF2HCH2,Et,CF2HCH2],

[RY727;MeOCH2,Et,Et] , [RY728;MeOCH2,Et,Pr] , [RY729;MeOCH2,Et,i-Pr] ,

[RY730;MeOCH 2,Et,c-Pr] , [RY731;MeOCH2,Et,t-Bu] , [RY732;MeOCH 2,Et,Bu],

[RY733;MeOCH 2,Et,t-Bu], [RY734;MeOCH 2,Et,c-PrCH2], [RY735;MeOCH 2,Et,Ph],

[RY736;MeOCH 2,Et,Bn], [RY737;MeOCH 2,Et,CF3], [RY738;MeOCH 2,Et,CF3CH2],

[RY739;MeOCH 2,Et,CF3CF2], [RY740;MeOCH 2,Et,CF2H], [RY741;MeOCH2,Et,CF2

HCH2], [RY742;EtOCH 2,Et,Et], [RY743;EtOCH 2,Et,Pr], [RY744;EtOCH2,Et,i-Pr],

[RY745;EtOCH2,Et,c-Pr] , [RY746;EtOCH2,Et,t-Bu], [RY747;EtOCH2,Et,Bu] ,

[RY748;EtOCH2,Et,t-Bu], [RY749;EtOCH2,Et,c-PrCH2], [RY750;EtOCH 2,Et,Ph],

[RY751;EtOCH 2,Et,Bn], [RY752;EtOCH2,Et,CF3], [RY753;EtOCH2,Et,CF3CH2],

[RY754;EtOCH 2,Et,CF3CF2], [RY755;EtOCH2,Et,CF2H], [RY756;EtOCH2,Et,CF2

HCH2], [RY757;MeSCH 2,Et,Et], [RY758;MeSCH 2,Et,Pr], [RY759;MeSCH 2,Et,i-Pr],

[RY760;MeSCH 2,Et,c-Pr] , [RY761;MeSCH2,Et,t-Bu], [RY762;MeSCH 2,Et,Bu] ,

[RY763;MeSCH 2,Et,t-Bu], [RY764;MeSCH 2,Et,c-PrCH2], [RY765;MeSCH 2,Et,Ph],

[RY766;MeSCH 2,Et,Bn] , [RY767;MeSCH2,Et,CF3], [RY768;MeSCH2,Et,CF3CH2],

[RY769;MeSCH 2,Et,CF3CF2], [RY770;MeSCH 2,Et,CF2H], [RY771;MeSCH2,Et,CF2

HCH2], [RY772;EtSCH 2,Et,Et], [RY773;EtSCH 2,Et,Pr], [RY774;EtSCH 2,Et,i-Pr],

[RY775;EtSCH 2,Et,c-Pr], [RY776;EtSCH 2,Et,t-Bu], [RY777;EtSCH 2,Et,Bu],

[RY778;EtSCH 2,Et,t-Bu], [RY779;EtSCH 2,Et,c-PrCH2], [RY780;EtSCH 2,Et,Ph],

[RY781;EtSCH 2,Et,Bn], [RY782;EtSCH 2,Et,CF3], [RY783;EtSCH 2,Et,CF3CH2],

[RY784;EtSCH 2,Et,CF3CF2], [RY785;EtSCH 2,Et,CF2H], [RY786;EtSCH 2,Et,CF2HCH2 ], [RY787;Ph,Et,Et], [RY788;Ph,Et,Pr], [RY789;Ph,Et,i-Pr], [RY790;Ph,Et,c-Pr],

[RY791;Ph,Et,t-Bu], [RY792;Ph,Et,Bu], [RY793;Ph,Et,t-Bu], [RY794;Ph,Et,c-PrCH 2], [RY795;Ph,Et,Ph], [RY796;Ph,Et,Bn], [RY797;Ph,Et,CF3], [RY798;Ph,Et,CF3CH2],

[RY799;Ph,Et,CF3CF2], [RY800;Ph,Et,CF2H],

[RY801;Ph,Et,CF2HCH2], [RY802;Bn,Et,Et], [RY803;Bn,Et,Pr], [RY804;Bn,Et,i-Pr], [RY805;Bn,Et,c-Pr], [RY806;Bn,Et,t-Bu], [RY807;Bn,Et,Bu],

[RY808;Bn,Et,t-Bu], [RY809;Bn,Et,c-PrCH 2], [RY810;Bn,Et,Ph], [RY811;Bn,Et,Bn],

[RY812;Bn,Et,CF 3], [RY813;Bn,Et,CF 3CH2], [RY814;Bn,Et,CF3CF2],

[RY815;Bn,Et,CF2H], [RY816;Bn,Et,CF2HCH2], [RY817;HCCCH2,Et,Et] ,

[RY818;HCCCH2,Et,Pr], [RY819;HCCCH2,Et,i-Pr], [RY820;HCCCH2,Et,c-Pr],

[RY821;HCCCH2,Et,t-Bu] , [RY822;HCCCH2,Et,Bu], [RY823;HCCCH2,Et,t-Bu],

[RY824;HCCCH2,Et,c-PrCH2], [RY825;HCCCH2,Et,Ph] , [RY826;HCCCH2,Et,Bn] ,

[RY827;HCCCH2,Et,CF3], [RY828;HCCCH2,Et,CF3CH2], [RY829;HCCCH2,Et,CF3CF

2], [RY830;HCCCH2,Et,CF2H], [RY831;HCCCH2,Et,CF2HCH2], [RY832;CH3CCCH2

,Et,Et], [RY833;CH3CCCH2,Et,Pr], [RY834;CH3CCCH2,Et,i-Pr], [RY835;CH3CCCH2

,Et,c-Pr], [RY836;CH3CCCH2,Et,t-Bu], [RY837;CH3CCCH2,Et,Bu], [RY838;CH3

CCCH2,Et,t-Bu] , [RY839;CH3CCCH2,Et,c-PrCH2], [RY840;CH3CCCH2,Et,Ph] ,

[RY841;CH3CCCH2,Et,Bn] , [RY842;CH3CCCH2,Et,CF3], [RY843;CH3CCCH2,Et,CF3

CH2], [RY844;CH3CCCH2,Et,CF3CF2], [RY845;CH3CCCH2,Et,CF2H], [RY846;CH3

CCCH2,Et,CF2HCH2], [RY847;H,Pr,Pr], [RY848;H,Pr,i-Pr], [RY849;H,Pr,c-Pr],

[RY850;H,Pr,t-Bu], [RY851;H,Pr,Bu], [RY852;H,Pr,t-Bu], [RY853;H,Pr,c-PrCH 2],

[RY854;H,Pr,Ph], [RY855;H,Pr,Bn], [RY856;H,Pr,CF3], [RY857;H,Pr,CF3CH2],

[RY858;H,Pr,CF3CF2], [RY859;H,Pr,CF2H], [RY860;H,Pr,CF2HCH2], [RY861;Me,Pr,Me], [RY862;Me,Pr,Et], [RY863;Me,Pr,Pr], [RY864;Me,Pr,i-Pr], [RY865;Me,Pr,c-Pr], [RY866;Me,Pr,t-Bu], [RY867;Me,Pr,Bu], [RY868;Me,Pr,t-Bu],

[RY869;Me,Pr,c-PrCH 2], [RY870;Me,Pr,Ph], [RY871;Me,Pr,Bn], [RY872;Me,Pr,CF 3

], [RY873;Me,Pr,CF 3CH2], [RY874;Me,Pr,CF 3CF2], [RY875;Me,Pr,CF 2H],

[RY876;Me,Pr,CF 2HCH2], [RY877;Et,Pr,Pr], [RY878;Et,Pr,i-Pr], [RY879;Et,Pr,c-Pr],

[RY880;Et,Pr,t-Bu], [RY881;Et,Pr,Bu], [RY882;Et,Pr,t-Bu], [RY883;Et,Pr,c-PrCH 2],

[RY884;Et,Pr,Ph], [RY885;Et,Pr,Bn], [RY886;Et,Pr,CF3], [RY887;Et,Pr,CF3CH2],

[RY888;Et,Pr,CF3CF2], [RY889;Et,Pr,CF2H], [RY890;Et,Pr,CF2HCH2], [RY891;Pr,Pr,Pr], [RY892;Pr,Pr,i-Pr], [RY893;Pr,Pr,c-Pr], [RY894;Pr,Pr,t-Bu],

[RY895;Pr,Pr,Bu], [RY896;Pr,Pr,t-Bu], [RY897;Pr,Pr,c-PrCH 2], [RY898;Pr,Pr,Ph],

[RY899;Pr,Pr,Bn], [RY900;Pr,Pr,CF3], [RY901;Pr,Pr,CF3CH2], [RY902;Pr,Pr,CF3CF2

], [RY903;Pr,Pr,CF2H], [RY904;Pr,Pr,CF2HCH2], [RY905;i-Pr,Pr,Pr], [RY906;i-Pr,Pr,i-Pr], [RY907;i-Pr,Pr,c-Pr], [RY908;i-Pr,Pr,t-Bu], [RY909;i-Pr,Pr,Bu],

[RY910;i-Pr,Pr,t-Bu], [RY91 l;i-Pr,Pr,c-PrCH 2], [RY912;i-Pr,Pr,Ph],

[RY913;i-Pr,Pr,Bn], [RY914;i-Pr,Pr,CF 3], [RY915;i-Pr,Pr,CF3CH2],

[RY916;i-Pr,Pr,CF3CF2], [RY917;i-Pr,Pr,CF2H], [RY918;i-Pr,Pr,CF2HCH2], [RY919;c-Pr,Pr,Pr], [RY920;c-Pr,Pr,i-Pr], [RY921;c-Pr,Pr,c-Pr], [RY922;c-Pr,Pr,t-Bu], [RY923;c-Pr,Pr,Bu], [RY924;c-Pr,Pr,t-Bu],

[RY925;c-Pr,Pr,c-PrCH2], [RY926;c-Pr,Pr,Ph], [RY927;c-Pr,Pr,Bn],

[RY928;c-Pr,Pr,CF3], [RY929;c-Pr,Pr,CF3CH2], [RY930;c-Pr,Pr,CF3CF2],

[RY931;c-Pr,Pr,CF2H], [RY932;c-Pr,Pr,CF2HCH2], [RY933;c-PrCH2,Pr,Pr],

[RY934;c-PrCH2,Pr,i-Pr], [RY935;c-PrCH2,Pr,c-Pr], [RY936;c-PrCH2,Pr,t-Bu],

[RY937;c-PrCH2,Pr,Bu], [RY938;c-PrCH2,Pr,t-Bu], [RY939;c-PrCH2,Pr,c-PrCH2],

[RY940;c-PrCH2,Pr,Ph], [RY941;c-PrCH2,Pr,Bn], [RY942;c-PrCH2,Pr,CF3],

[RY943;c-PrCH2,Pr,CF3CH2], [RY944;c-PrCH2,Pr,CF3CF2], [RY945;c-PrCH2,Pr,CF2

H], [RY946;c-PrCH2,Pr,CF2HCH2], [RY947;i-Bu,Pr,Pr], [RY948;i-Bu,Pr,i-Pr], [RY949;i-Bu,Pr,c-Pr], [RY950;i-Bu,Pr,t-Bu], [RY951;i-Bu,Pr,Bu],

[RY952;i-Bu,Pr,t-Bu], [RY953;i-Bu,Pr,c-PrCH2], [RY954;i-Bu,Pr,Ph],

[RY955;i-Bu,Pr,Bn], [RY956;i-Bu,Pr,CF3], [RY957;i-Bu,Pr,CF3CH2],

[RY958;i-Bu,Pr,CF3CF2], [RY959;i-Bu,Pr,CF2H], [RY960;i-Bu,Pr,CF2HCH2],

[RY961;CF3CH2,Pr,Pr], [RY962;CF3CH2,Pr,i-Pr], [RY963;CF3CH2,Pr,c-Pr],

[RY964;CF3CH2,Pr,t-Bu], [RY965;CF3CH2,Pr,Bu], [RY966;CF3CH2,Pr,t-Bu],

[RY967;CF3CH2,Pr,c-PrCH2], [RY968;CF3CH2,Pr,Ph], [RY969;CF3CH2,Pr,Bn],

[RY970;CF3CH2,Pr,CF3], [RY971;CF3CH2,Pr,CF3CH2], [RY972;CF3CH2,Pr,CF3CF2],

[RY973;CF3CH2,Pr,CF2H], [RY974;CF3CH2,Pr,CF2HCH2], [RY975;CF2HCH2,Pr,Pr],

[RY976;CF2HCH2,Pr,i-Pr], [RY977;CF2HCH2,Pr,c-Pr], [RY978;CF2HCH2,Pr,t-Bu],

[RY979;CF2HCH2,Pr,Bu], [RY980;CF2HCH2,Pr,t-Bu], [RY981;CF2HCH2,Pr,c-PrCH2],

[RY982;CF2HCH2,Pr,Ph], [RY983;CF2HCH2,Pr,Bn], [RY984;CF2HCH2,Pr,CF3],

[RY985;CF2HCH2,Pr,CF3CH2], [RY986;CF2HCH2,Pr,CF3CF2], [RY987;CF2HCH2

,Pr,CF2H], [RY988;CF2HCH2,Pr,CF2HCH2], [RY989;MeOCH2,Pr,Pr],

[RY990;MeOCH2,Pr,i-Pr], [RY991;MeOCH2,Pr,c-Pr], [RY992;MeOCH2,Pr,t-Bu],

[RY993;MeOCH2,Pr,Bu], [RY994;MeOCH2,Pr,t-Bu], [RY995;MeOCH2,Pr,c-PrCH2],

[RY996;MeOCH2,Pr,Ph], [RY997;MeOCH2,Pr,Bn], [RY998;MeOCH2,Pr,CF3],

[RY999;MeOCH2,Pr,CF3CH2], [RY1000;MeOCH2,Pr,CF3CF2],

[RY1001;MeOCH2,Pr,CF2H], [RY1002;MeOCH2,Pr,CF2HCH2], [RY1003;EtOCH2

,Pr,Pr], [RY1004;EtOCH2,Pr,i-Pr], [RY1005;EtOCH2,Pr,c-Pr], [RY1006;EtOCH2

,Pr,t-Bu], [RY1007;EtOCH2,Pr,Bu], [RY1008;EtOCH2,Pr,t-Bu], [RY1009;EtOCH2

,Pr,c-PrCH2], [RY1010;EtOCH2,Pr,Ph], [RY1011;EtOCH2,Pr,Bn], [RY1012;EtOCH2

,Pr,CF3], [RY1013;EtOCH2,Pr,CF3CH2], [RY1014;EtOCH2,Pr,CF3CF2],

[RY1015;EtOCH2,Pr,CF2H], [RY1016;EtOCH2,Pr,CF2HCH2], [RY1017;MeSCH2

,Pr,Pr], [RY1018;MeSCH2,Pr,i-Pr], [RY1019;MeSCH2,Pr,c-Pr], [RY1020;MeSCH2

,Pr,t-Bu], [RY1021;MeSCH2,Pr,Bu], [RY1022;MeSCH2,Pr,t-Bu], [RY1023;MeSCH2

,Pr,c-PrCH2], [RY1024;MeSCH2,Pr,Ph], [RY1025;MeSCH2,Pr,Bn], [RY1026;MeSCH2

,Pr,CF3], [RY1027;MeSCH2,Pr,CF3CH2], [RY1028;MeSCH2,Pr,CF3CF2],

[RY1029;MeSCH2,Pr,CF2H], [RY1030;MeSCH2,Pr,CF2HCH2], [RY1031;EtSCH2 Ρ ΓΡ Γ , , ], [RY1032;EtSCH2,Pr,i-Pr], [RY1033;EtSCH 2,Pr,c-Pr], [RY1034;EtSCH2

,Pr,t-Bu], [RY1035;EtSCH2,Pr,Bu], [RY1036;EtSCH2,Pr,t-Bu], [RY1037;EtSCH2

,Pr,c-PrCH2], [RY1038;EtSCH 2,Pr,Ph], [RY1039;EtSCH2,Pr,Bn], [RY1040;EtSCH2

,Pr,CF3], [RY1041;EtSCH2,Pr,CF3CH2], [RY1042;EtSCH 2,Pr,CF3CF2], [RY1043;EtSCH2,Pr,CF2H], [RY1044;EtSCH 2,Pr,CF2HCH2], [RY1045;Ph,Pr,Pr], [RY1046;Ph,Pr,i-Pr], [RY1047;Ph,Pr,c-Pr], [RY1048;Ph,Pr,t-Bu], [RY1049;Ph,Pr,Bu],

[RY1050;Ph,Pr,t-Bu], [RY1051;Ph,Pr,c-PrCH 2], [RY1052;Ph,Pr,Ph],

[RY1053;Ph,Pr,Bn], [RY1054;Ph,Pr,CF 3], [RY1055;Ph,Pr,CF 3CH2],

[RY1056;Ph,Pr,CF 3CF2], [RY1057;Ph,Pr,CF 2H], [RY1058;Ph,Pr,CF 2HCH2], [RY1059;Bn,Pr,Pr], [RY1060;Bn,Pr,i-Pr], [RY1061;Bn,Pr,c-Pr], [RY1062;Bn,Pr,t-Bu], [RY1063;Bn,Pr,Bu], [RY1064;Bn,Pr,t-Bu],

[RY1065;Bn,Pr,c-PrCH 2], [RY1066;Bn,Pr,Ph], [RY1067;Bn,Pr,Bn],

[RY1068;Bn,Pr,CF3], [RY1069;Bn,Pr,CF3CH2], [RY1070;Bn,Pr,CF 3CF2],

[RY107 1;Bn,Pr,CF2H], [RY1072;Bn,Pr,CF 2HCH2], [RY1073;HCCCH2,Pr,Pr],

[RY1074;HCCCH 2,Pr,i-Pr], [RY1075;HCCCH2,Pr,c-Pr], [RY1076;HCCCH 2,Pr,t-Bu],

[RY1077;HCCCH 2,Pr,Bu], [RY1078;HCCCH 2,Pr,t-Bu], [RY1079;HCCCH 2

,Pr,c-PrCH2], [RY1080;HCCCH 2,Pr,Ph], [RY1081;HCCCH2,Pr,Bn],

[RY1082;HCCCH 2,Pr,CF3], [RY1083;HCCCH2,Pr,CF3CH2], [RY1084;HCCCH 2,Pr,CF

3CF2], [RY1085;HCCCH 2,Pr,CF2H], [RY1086;HCCCH 2,Pr,CF2HCH2], [RY1087;CH3

CCCH2,Pr,Pr], [RY1088;CH3CCCH2,Pr,i-Pr], [RY1089;CH3CCCH2,Pr,c-Pr],

[RY1090;CH3CCCH2,Pr,t-Bu], [RY1091;CH3CCCH2,Pr,Bu], [RY1092;CH3CCCH2

,Pr,t-Bu], [RY1093;CH3CCCH2,Pr,c-PrCH2], [RY1094;CH3CCCH2,Pr,Ph],

[RY1095;CH3CCCH2,Pr,Bn], [RY1096;CH3CCCH2,Pr,CF3], [RY1097;CH3CCCH2 ,Pr,CF3CH2], [RY1098;CH3CCCH2,Pr,CF3CF2], [RY1099;CH3CCCH2,Pr,CF2H],

[RY1 100;CH3CCCH2,Pr,CF2HCH2], [RY1 101;H,i-Pr,i-Pr], [RY1 102;H,i-Pr,c-Pr], [RY1103;H,i-Pr,t-Bu], [RY1104;H,i-Pr,Bu], [RY1105;H,i-Pr,t-Bu],

[RY1106;H,i-Pr,c-PrCH 2], [RY1107;H,i-Pr,Ph], [RY1108;H,i-Pr,Bn],

[RY1 109;H,i-Pr,CF3], [RY1 110;H,i-Pr,CF3CH2], [RY1 11l;H,i-Pr,CF 3CF2],

[RY1 112;H,i-Pr,CF2H], [RY1 113;H,i-Pr,CF2HCH2], [RY1 114;Me,i-Pr,i-Pr], [RY1 115;Me,i-Pr,c-Pr], [RY1 116;Me,i-Pr,t-Bu], [RY1 117;Me,i-Pr,Bu],

[RY1 118;Me,i-Pr,t-Bu], [RY1 119;Me,i-Pr,c-PrCH2], [RY1 120;Me,i-Pr,Ph],

[RY1 121;Me,i-Pr,Bn], [RY1 122;Me,i-Pr,CF3], [RY1 123;Me,i-Pr,CF3CH2],

[RY1 124;Me,i-Pr,CF3CF2], [RY1 125;Me,i-Pr,CF2H], [RY1 126;Me,i-Pr,CF2HCH2], [RY1 127;Et,i-Pr,i-Pr], [RY1 128;Et,i-Pr,c-Pr], [RY1 129;Et,i-Pr,t-Bu],

[RY1 130;Et,i-Pr,Bu], [RY1 131;Et,i-Pr,t-Bu], [RY1 132;Et,i-Pr,c-PrCH2],

[RY1133;Et,i-Pr,Ph], [RY1134;Et,i-Pr,Bn], [RY1135;Et,i-Pr,CF 3],

[RY1 136;Et,i-Pr,CF3CH2], [RY1 137;Et,i-Pr,CF3CF2], [RY1 138;Et,i-Pr,CF2H],

[RY1 139;Et,i-Pr,CF2HCH2], [RY1140;Pr,i-Pr,i-Pr], [RY1 141;Pr,i-Pr,c-Pr], [RYl 142;Pr,i-Pr,t-Bu], [RYl 143;Pr,i-Pr,Bu], [RYl 144;Pr,i-Pr,t-Bu],

[RYl 145;Pr,i-Pr,c-PrCH2], [RYl 146;Pr,i-Pr,Ph], [RYl 147;Pr,i-Pr,Bn],

[RYl 148;Pr,i-Pr,CF3], [RYl 149;Pr,i-Pr,CF3CH2], [RYl 150;Pr,i-Pr,CF3CF2],

[RYl 151;Pr,i-Pr,CF2H], [RYl 152;Pr,i-Pr,CF2HCH2], [RYl 153;i-Pr,i-Pr,i-Pr], [RYl 154;i-Pr,i-Pr,c-Pr], [RYl 155;i-Pr,i-Pr,t-Bu], [RYl 156;i-Pr,i-Pr,Bu],

[RYl 157;i-Pr,i-Pr,t-Bu], [RYl 158;i-Pr,i-Pr,c-PrCH2], [RYl 159;i-Pr,i-Pr,Ph],

[RYl 160;i-Pr,i-Pr,Bn], [RYl 161;i-Pr,i-Pr,CF3], [RYl 162;i-Pr,i-Pr,CF3CH2],

[RYl 163;i-Pr,i-Pr,CF3CF2], [RYl 164;i-Pr,i-Pr,CF2H], [RYl 165;i-Pr,i-Pr,CF2HCH2], [RYl 166;c-Pr,i-Pr,i-Pr], [RYl 167;c-Pr,i-Pr,c-Pr], [RYl 168;c-Pr,i-Pr,t-Bu],

[RYl 169;c-Pr,i-Pr,Bu], [RYl 170;c-Pr,i-Pr,t-Bu], [RYl 171;c-Pr,i-Pr,c-PrCH2],

[RYl 172;c-Pr,i-Pr,Ph], [RYl 173;c-Pr,i-Pr,Bn], [RYl 174;c-Pr,i-Pr,CF3],

[RYl 175;c-Pr,i-Pr,CF3CH2], [RYl 176;c-Pr,i-Pr,CF3CF2], [RYl 177;c-Pr,i-Pr,CF2H],

[RYl 178;c-Pr,i-Pr,CF2HCH2], [RYl 179;c-PrCH2,i-Pr,i-Pr], [RYl 180;c-PrCH2

,i-Pr,c-Pr], [RY1181;c-PrCH2,i-Pr,t-Bu], [RY1182;c-PrCH2,i-Pr,Bu], [RY1183;c-PrCH

2,i-Pr,t-Bu], [RYl 184;c-PrCH2,i-Pr,c-PrCH2], [RYl 185;c-PrCH2,i-Pr,Ph],

[RYl 186;c-PrCH2,i-Pr,Bn], [RY1187 ;c-PrCH2,i-Pr,CF3], [RYl 188;c-PrCH2,i-Pr,CF3

CH2], [RY1189;c-PrCH2,i-Pr,CF3CF2], [RY1190;c-PrCH2,i-Pr,CF2H],

[RYl 191;c-PrCH2,i-Pr,CF2HCH2], [RYl 192;i-Bu,i-Pr,i-Pr], [RYl 193;i-Bu,i-Pr,c-Pr], [RYl 194;i-Bu,i-Pr,t-Bu], [RYl 195;i-Bu,i-Pr,Bu], [RYl 196;i-Bu,i-Pr,t-Bu],

[RYl 197;i-Bu,i-Pr,c-PrCH2], [RYl 198;i-Bu,i-Pr,Ph], [RYl 199;i-Bu,i-Pr,Bn],

[RY1200;i-Bu,i-Pr,CF 3],

[RY120 1;i-Bu,i-Pr,CF3CH2], [RY1202;i-Bu,i-Pr,CF 3CF2], [RY1203 ;i-Bu,i-Pr,CF2H],

[RY1204;i-Bu,i-Pr,CF 2HCH2], [RY1205;CF3CH2,i-Pr,i-Pr], [RY1206;CF3CH2

,i-Pr,c-Pr], [RY1207;CF3CH2,i-Pr,t-Bu], [RY1208;CF3CH2,i-Pr,Bu], [RY1209;CF3CH2

,i-Pr,t-Bu], [RY1210;CF3CH2,i-Pr,c-PrCH2], [RY1211;CF3CH2,i-Pr,Ph], [RY1212;CF3

CH2,i-Pr,Bn], [RY1213;CF3CH2,i-Pr,CF3], [RY1214;CF3CH2,i-Pr,CF3CH2],

[RY1215;CF3CH2,i-Pr,CF3CF2], [RY1216;CF3CH2,i-Pr,CF2H], [RY1217;CF3CH2

,i-Pr,CF2HCH2], [RY1218;CF2HCH2,i-Pr,i-Pr], [RY1219;CF2HCH2,i-Pr,c-Pr],

[RY1220;CF2HCH2,i-Pr,t-Bu], [RY1221;CF2HCH2,i-Pr,Bu], [RY1222;CF2HCH2

,i-Pr,t-Bu], [RY1223;CF2HCH2,i-Pr,c-PrCH2], [RY1224;CF2HCH2,i-Pr,Ph],

[RY1225;CF2HCH2,i-Pr,Bn], [RY1226;CF2HCH2,i-Pr,CF3], [RY1227;CF2HCH2

,i-Pr,CF3CH2], [RY1228;CF2HCH2,i-Pr,CF3CF2], [RY1229;CF2HCH2,i-Pr,CF2H],

[RY1230;CF2HCH2,i-Pr,CF2HCH2], [RY1231;MeOCH2,i-Pr,i-Pr], [RY1232;MeOCH2

,i-Pr,c-Pr], [RY1233 ;MeOCH2,i-Pr,t-Bu], [RY1234;MeOCH2,i-Pr,Bu],

[RY1235;MeOCH2,i-Pr,t-Bu], [RY1236;MeOCH2,i-Pr,c-PrCH2], [RY1237;MeOCH2

,i-Pr,Ph], [RY1238;MeOCH2,i-Pr,Bn], [RY1239;MeOCH2,i-Pr,CF3],

[RY1240;MeOCH2,i-Pr,CF3CH2], [RY1241;MeOCH2,i-Pr,CF3CF2], [RY1242;MeOCH

2,i-Pr,CF2H], [RY1243;MeOCH2,i-Pr,CF2HCH2], [RY1244;EtOCH 2,i-Pr,i-Pr], [RY1245;EtOCH 2,i-Pr,c-Pr], [RY1246;EtOCH 2,i-Pr,t-Bu], [RY1247;EtOCH 2,i-Pr,Bu],

[RY1248;EtOCH 2,i-Pr,t-Bu], [RY1249;EtOCH 2,i-Pr,c-PrCH 2], [RY1250;EtOCH 2

,i-Pr,Ph], [RY1251;EtOCH 2,i-Pr,Bn], [RY1252;EtOCH 2,i-Pr,CF3], [RY1253;EtOCH 2

,i-Pr,CF3CH2], [RY1254;EtOCH 2,i-Pr,CF3CF2], [RY1255;EtOCH2,i-Pr,CF2H],

[RY1256;EtOCH 2,i-Pr,CF2HCH2], [RY1257;MeSCH 2,i-Pr,i-Pr], [RY1258;MeSCH 2

,i-Pr,c-Pr], [RY1259;MeSCH 2,i-Pr,t-Bu], [RY1260;MeSCH 2,i-Pr,Bu],

[RY1261;MeSCH 2,i-Pr,t-Bu], [RY1262;MeSCH 2,i-Pr,c-PrCH 2], [RY1263;MeSCH 2

,i-Pr,Ph], [RY1264;MeSCH 2,i-Pr,Bn], [RY1265;MeSCH 2,i-Pr,CF3], [RY1266;MeSCH 2

,i-Pr,CF3CH2], [RY1267;MeSCH2,i-Pr,CF3CF2], [RY1268;MeSCH2,i-Pr,CF2H],

[RY1269;MeSCH 2,i-Pr,CF2HCH2], [RY1270;EtSCH 2,i-Pr,i-Pr], [RY1271;EtSCH 2

,i-Pr,c-Pr], [RY1272;EtSCH 2,i-Pr,t-Bu], [RY1273;EtSCH 2,i-Pr,Bu], [RY1274;EtSCH 2

,i-Pr,t-Bu], [RY1275;EtSCH 2,i-Pr,c-PrCH 2], [RY1276;EtSCH 2,i-Pr,Ph],

[RY1277;EtSCH 2,i-Pr,Bn], [RY1278;EtSCH 2,i-Pr,CF3], [RY1279;EtSCH 2,i-Pr,CF3CH2

], [RY1280;EtSCH 2,i-Pr,CF3CF2], [RY1281;EtSCH 2,i-Pr,CF2H], [RY1282;EtSCH 2

,i-Pr,CF2HCH2], [RY1283;Ph,i-Pr,i-Pr], [RY1284;Ph,i-Pr,c-Pr], [RY1285;Ph,i-Pr,t-Bu], [RY1286;Ph,i-Pr,Bu], [RY1287;Ph,i-Pr,t-Bu],

[RY1288;Ph,i-Pr,c-PrCH 2], [RY1289;Ph,i-Pr,Ph], [RY1290;Ph,i-Pr,Bn],

[RY1291;Ph,i-Pr,CF3], [RY1292;Ph,i-Pr,CF 3CH2], [RY1293;Ph,i-Pr,CF3CF2],

[RY1294;Ph,i-Pr,CF 2H], [RY1295;Ph,i-Pr,CF 2HCH2], [RY1296;Bn,i-Pr,i-Pr], [RY1297;Bn,i-Pr,c-Pr], [RY1298;Bn,i-Pr,t-Bu], [RY1299;Bn,i-Pr,Bu],

[RY1300;Bn,i-Pr,t-Bu] , [RY1301;Bn,i-Pr,c-PrCH 2], [RY1302;Bn,i-Pr,Ph] ,

[RY1303;Bn,i-Pr,Bn] , [RY1304;Bn,i-Pr,CF 3], [RY1305;Bn,i-Pr,CF3CH2],

[RY1306;Bn,i-Pr,CF3CF2], [RY1307;Bn,i-Pr,CF2H], [RY1308;Bn,i-Pr,CF2HCH2],

[RY1309;HCCCH 2,i-Pr,i-Pr], [RY1310;HCCCH 2,i-Pr,c-Pr], [RY131 1;HCCCH2

,i-Pr,t-Bu] , [RY1312;HCCCH2,i-Pr,Bu], [RY1313;HCCCH2,i-Pr,t-Bu],

[RY1314;HCCCH 2,i-Pr,c-PrCH 2], [RY1315;HCCCH2,i-Pr,Ph], [RY1316;HCCCH2

,i-Pr,Bn], [RY1317;HCCCH2,i-Pr,CF3], [RY1318;HCCCH2,i-Pr,CF3CH2],

[RY1319;HCCCH2,i-Pr,CF3CF2], [RY1320;HCCCH 2,i-Pr,CF2H], [RY1321;HCCCH2

,i-Pr,CF2HCH2], [RY1322;CH3CCCH2,i-Pr,i-Pr], [RY1323;CH3CCCH2,i-Pr,c-Pr],

[RY1324;CH3CCCH2,i-Pr,t-Bu], [RY1325;CH3CCCH2,i-Pr,Bu], [RY1326;CH3CCCH2

,i-Pr,t-Bu] , [RY1327;CH3CCCH2,i-Pr,c-PrCH 2], [RY1328;CH3CCCH2,i-Pr,Ph],

[RY1329;CH3CCCH2,i-Pr,Bn], [RY1330;CH3CCCH2,i-Pr,CF3], [RY133 1;CH3CCCH2

,i-Pr,CF3CH2], [RY1332;CH3CCCH2,i-Pr,CF3CF2], [RY1333;CH3CCCH2,i-Pr,CF2H],

[RY1334;CH 3CCCH2,i-Pr,CF2HCH2], [RY1335;H,c-Pr,c-Pr], [RY1336;H,c-Pr,t-Bu],

[RY1337 ;H,c-Pr,Bu], [RY1338;H,c-Pr,t-Bu] , [RY1339;H,c-Pr,c-PrCH 2],

[RY1340;H,c-Pr,Ph], [RY1341;H,c-Pr,Bn], [RY1342;H,c-Pr,CF 3],

[RY1343;H,c-Pr,CF3CH2], [RY1344;H,c-Pr,CF 3CF2], [RY1345;H,c-Pr,CF2H],

[RY1346;H,c-Pr,CF2HCH2], [RY1347;Me,c-Pr,c-Pr] , [RY1348;Me,c-Pr,t-Bu] , [RY1349;Me,c-Pr,Bu], [RY1350;Me,c-Pr,t-Bu], [RY1351;Me,c-Pr,c-PrCH 2],

[RY1352;Me,c-Pr,Ph], [RY1353;Me,c-Pr,Bn], [RY1354;Me,c-Pr,CF 3],

[RY1355;Me,c-Pr,CF 3CH2], [RY1356;Me,c-Pr,CF 3CF2], [RY1357;Me,c-Pr,CF 2H],

[RY1358;Me,c-Pr,CF 2HCH2], [RY1359;Et,c-Pr,c-Pr], [RY1360;Et,c-Pr,t-Bu],

[RY1361;Et,c-Pr,Bu], [RY1362;Et,c-Pr,t-Bu], [RY1363;Et,c-Pr,c-PrCH 2],

[RY1364;Et,c-Pr,Ph], [RY1365;Et,c-Pr,Bn], [RY1366;Et,c-Pr,CF 3],

[RY1367;Et,c-Pr,CF3CH2], [RY1368;Et,c-Pr,CF3CF2], [RY1369;Et,c-Pr,CF 2H],

[RY1370;Et,c-Pr,CF 2HCH2], [RY137 1;Pr,c-Pr,c-Pr], [RY1372;Pr,c-Pr,t-Bu] ,

[RY1373;Pr,c-Pr,Bu], [RY1374;Pr,c-Pr,t-Bu], [RY1375;Pr,c-Pr,c-PrCH 2],

[RY1376;Pr,c-Pr,Ph], [RY1377;Pr,c-Pr,Bn], [RY1378;Pr,c-Pr,CF 3],

[RY1379;Pr,c-Pr,CF3CH2], [RY1380;Pr,c-Pr,CF 3CF2], [RY1381;Pr,c-Pr,CF2H],

[RY1382;Pr,c-Pr,CF 2HCH2], [RY1383;i-Pr,c-Pr,c-Pr] , [RY1384;i-Pr,c-Pr,t-B u],

[RY1385;i-Pr,c-Pr,Bu] , [RY1386;i-Pr,c-Pr,t-Bu] , [RY1387;i-Pr,c-Pr,c-PrCH 2],

[RY1388;i-Pr,c-Pr,Ph], [RY1389;i-Pr,c-Pr,Bn] , [RY1390;i-Pr,c-Pr,CF 3],

[RY139 1;i-Pr,c-Pr,CF3CH2], [RY1392;i-Pr,c-Pr,CF 3CF2], [RY1393;i-Pr,c-Pr,CF2H],

[RY1394;i-Pr,c-Pr,CF 2HCH2], [RY1395;c-Pr,c-Pr,c-Pr] , [RY1396;c-Pr,c-Pr,t-Bu],

[RY1397;c-Pr,c-Pr,Bu], [RY1398;c-Pr,c-Pr,t-Bu] , [RY1399;c-Pr,c-Pr,c-PrCH 2], [RY1400;c-Pr,c-Pr,Ph],

[RY1401;c-Pr,c-Pr,Bn] , [RY1402;c-Pr,c-Pr,CF 3], [RY1403;c-Pr,c-Pr,CF3CH2],

[RY1404;c-Pr,c-Pr,CF 3CF2], [RY1405;c-Pr,c-Pr,CF 2H], [RY1406;c-Pr,c-Pr,CF 2HCH2],

[RY1407;c-PrCH 2,c-Pr,c-Pr], [RY1408;c-PrCH 2,c-Pr,t-Bu], [RY1409;c-PrCH 2

,c-Pr,Bu], [RY1410;c-PrCH 2,c-Pr,t-Bu], [RY141 l;c-PrCH 2,c-Pr,c-PrCH2],

[RY1412;c-PrCH 2,c-Pr,Ph], [RY1413;c-PrCH 2,c-Pr,Bn], [RY1414;c-PrCH 2,c-Pr,CF3],

[RY1415;c-PrCH 2,c-Pr,CF3CH2], [RY1416;c-PrCH 2,c-Pr,CF3CF2], [RY1417;c-PrCH 2

,c-Pr,CF2H], [RY1418;c-PrCH 2,c-Pr,CF2HCH2], [RY1419;i-Bu,c-Pr,c-Pr], [RY1420;i-Bu,c-Pr,t-Bu], [RY1421;i-Bu,c-Pr,Bu], [RY1422;i-Bu,c-Pr,t-Bu],

[RY1423 ;i-Bu,c-Pr,c-PrCH 2], [RY1424;i-Bu,c-Pr,Ph] , [RY1425 ;i-Bu,c-Pr,Bn],

[RY1426;i-Bu,c-Pr,CF 3], [RY1427;i-Bu,c-Pr,CF 3CH2], [RY1428;i-Bu,c-Pr,CF 3CF2],

[RY1429;i-Bu,c-Pr,CF 2H], [RY1430;i-Bu,c-Pr,CF 2HCH2], [RY1431;CF3CH2

,c-Pr,c-Pr], [RY1432;CF3CH2,c-Pr,t-Bu], [RY1433;CF3CH2,c-Pr,Bu], [RY1434;CF3CH

2,c-Pr,t-Bu], [RY1435;CF3CH2,c-Pr,c-PrCH2], [RY1436;CF3CH2,c-Pr,Ph],

[RY1437;CF3CH2,c-Pr,Bn], [RY1438;CF3CH2,c-Pr,CF3], [RY1439;CF3CH2,c-Pr,CF3

CH2], [RY1440;CF3CH2,c-Pr,CF3CF2], [RY1441;CF3CH2,c-Pr,CF2H], [RY1442;CF3

CH2,c-Pr,CF2HCH2], [RY1443;CF2HCH2,c-Pr,c-Pr], [RY1444;CF2HCH2,c-Pr,t-Bu] ,

[RY1445;CF2HCH2,c-Pr,Bu], [RY1446;CF2HCH2,c-Pr,t-Bu], [RY1447;CF2HCH2

,c-Pr,c-PrCH 2], [RY1448;CF2HCH2,c-Pr,Ph], [RY1449;CF2HCH2,c-Pr,Bn],

[RY1450;CF2HCH2,c-Pr,CF3], [RY145 1;CF2HCH2,c-Pr,CF3CH2], [RY1452;CF2HCH2

,c-Pr,CF3CF2], [RY1453;CF2HCH2,c-Pr,CF2H], [RY1454;CF2HCH2,c-Pr,CF2HCH2], [RY1455;MeOCH2,c-Pr,c-Pr], [RY1456;MeOCH2,c-Pr,t-Bu], [RY1457;MeOCH2

,c-Pr,Bu], [RY1458;MeOCH2,c-Pr,t-Bu], [RY1459;MeOCH2,c-Pr,c-PrCH2],

[RY1460;MeOCH2,c-Pr,Ph], [RY1461;MeOCH2,c-Pr,Bn], [RY1462;MeOCH2,c-Pr,CF 3], [RY1463;MeOCH2,c-Pr,CF3CH2], [RY1464;MeOCH2,c-Pr,CF3CF2],

[RY1465;MeOCH2,c-Pr,CF2H], [RY1466;MeOCH2,c-Pr,CF2HCH2], [RY1467;EtOCH2

,c-Pr,c-Pr], [RY1468;EtOCH2,c-Pr,t-Bu], [RY1469;EtOCH2,c-Pr,Bu],

[RY1470;EtOCH2,c-Pr,t-Bu], [RY1471;EtOCH2,c-Pr,c-PrCH2], [RY1472;EtOCH2

,c-Pr,Ph], [RY1473;EtOCH2,c-Pr,Bn], [RY1474;EtOCH2,c-Pr,CF3], [RY1475;EtOCH2 ,c-Pr,CF3CH2], [RY1476;EtOCH2,c-Pr,CF3CF2], [RY1477;EtOCH2,c-Pr,CF2H],

[RY1478;EtOCH2,c-Pr,CF2HCH2], [RY1479;MeSCH2,c-Pr,c-Pr], [RY1480;MeSCH2

,c-Pr,t-Bu], [RY1481;MeSCH2,c-Pr,Bu], [RY1482;MeSCH2,c-Pr,t-Bu], [RY1483;MeSCH2,c-Pr,c-PrCH2], [RY1484;MeSCH2,c-Pr,Ph], [RY1485;MeSCH2

,c-Pr,Bn], [RY1486;MeSCH2,c-Pr,CF3], [RY1487;MeSCH2,c-Pr,CF3CH2], [RY1488;MeSCH2,c-Pr,CF3CF2], [RY1489;MeSCH2,c-Pr,CF2H], [RY1490;MeSCH2

,c-Pr,CF2HCH2], [RY1491;EtSCH2,c-Pr,c-Pr], [RY1492;EtSCH2,c-Pr,t-Bu],

[RY1493;EtSCH2,c-Pr,Bu], [RY1494;EtSCH2,c-Pr,t-Bu], [RY1495;EtSCH2

,c-Pr,c-PrCH2], [RY1496;EtSCH2,c-Pr,Ph], [RY1497;EtSCH2,c-Pr,Bn],

[RY1498;EtSCH2,c-Pr,CF3], [RY1499;EtSCH2,c-Pr,CF3CH2], [RY1500;EtSCH2 ,c-Pr,CF3CF2], [RY1501;EtSCH2,c-Pr,CF2H], [RY1502;EtSCH2,c-Pr,CF2HCH2], [RY1503;Ph,c-Pr,c-Pr], [RY1504;Ph,c-Pr,t-Bu], [RY1505;Ph,c-Pr,Bu],

[RY1506;Ph,c-Pr,t-Bu], [RY1507;Ph,c-Pr,c-PrCH2], [RY1508;Ph,c-Pr,Ph],

[RY1509;Ph,c-Pr,Bn], [RY1510;Ph,c-Pr,CF3], [RY1511;Ph,c-Pr,CF3CH2], [RY1512;Ph,c-Pr,CF3CF2], [RY1513;Ph,c-Pr,CF2H], [RY1514;Ph,c-Pr,CF2HCH2], [RY1515;Bn,c-Pr,c-Pr], [RY1516;Bn,c-Pr,t-Bu], [RY1517 ;Bn,c-Pr,Bu],

[RY1518;Bn,c-Pr,t-Bu], [RY1519;Bn,c-Pr,c-PrCH2], [RY1520;Bn,c-Pr,Ph],

[RY1521;Bn,c-Pr,Bn], [RY1522;Bn,c-Pr,CF3], [RY1523;Bn,c-Pr,CF3CH2], [RY1524;Bn,c-Pr,CF3CF2], [RY1525;Bn,c-Pr,CF2H], [RY1526;Bn,c-Pr,CF2HCH2],

[RY1527;HCCCH2,c-Pr,c-Pr], [RY1528;HCCCH2,c-Pr,t-Bu], [RY1529;HCCCH2

,c-Pr,Bu], [RY1530;HCCCH2,c-Pr,t-Bu], [RY153 1;HCCCH2,c-Pr,c-PrCH2],

[RY1532;HCCCH2,c-Pr,Ph], [RY1533;HCCCH2,c-Pr,Bn], [RY1534;HCCCH2,c-Pr,CF

3], [RY1535;HCCCH2,c-Pr,CF3CH2], [RY1536;HCCCH2,c-Pr,CF3CF2],

[RY1537;HCCCH2,c-Pr,CF2H], [RY1538;HCCCH2,c-Pr,CF2HCH2], [RY1539;CH3

CCCH2,c-Pr,c-Pr], [RY1540;CH3CCCH2,c-Pr,t-Bu], [RY1541;CH3CCCH2,c-Pr,Bu],

[RY1542;CH3CCCH2,c-Pr,t-Bu], [RY1543;CH3CCCH2,c-Pr,c-PrCH2], [RY1544;CH3

CCCH2,c-Pr,Ph], [RY1545;CH3CCCH2,c-Pr,Bn], [RY1546;CH3CCCH2,c-Pr,CF3], [RY1547;CH3CCCH2,c-Pr,CF3CH2], [RY1548;CH3CCCH2,c-Pr,CF3CF2], [RY1549;CH

3CCCH2,c-Pr,CF2H], [RY1550;CH3CCCH2,c-Pr,CF2HCH2] The Present compound RA, the Present compound RB, the Present compound RC, the Present compound RD, the Present compound RE, the Present compound RF, the Present compound RG, the Present compound RH, the Present compound RI, the Present compound RJ, the Present compound RK, the Present compound RL, the Present compound RM, the Present compound RN, the Present compound RO, the Present compound RP, the Present compound RQ, the Present compound RR, the Present compound RS, the Present compound RT, the Present compound RU, the Present compound RV, the Present compound RW, the Present compound RX, and the Present compound RY are collectively referred to as "Present compound A". [0237] The Present compound can be mixed with or used in combination with a fungicide, an insecticide, a miticide, a nematicide, a plant growth regulator, or a synergist (hereinafter collectively referred to as "Present ingredient"). Pests such as harmful arthropods, harmful nematodes, and plant pathogens can be controlled by applying a composition comprising one or more agents selected from the group consisting of a fungicide, an insecticide, a miticide, a nematicide, a plant growth regulator, and a synergist, and the Present compound to a plant or a soil. Also, pests can be controlled by applying the Present compound and the Present ingredient separately. The fungicides are ingredients for use in protecting a plant from diseases derived from plant pathogens (e.g., filamentous fungi or bacteria). Examples of the fungicides include those specified by FRAC (Fungicide Resistance Action Committee). Examples of the insecticides, miticides, and nematicides include those specified by IRAC (Insecticide Resistance Action Committee). The plant growth regulators indicate ingredients for regulating the plant growth such as the promotion of fruit setting and the promotion of rooting. Examples of the plant growth regulators include indolebutyric acid. The synergists indicate ingredients which potentiate the efficacy of other agent when mixed with or used in combination with said agent. Examples of the synergists include piperonyl butoxide. [0238] Hereinafter, examples of the combination of the Present compound and the Present ingredient are described. For example, "tebuconazole+SX" indicates the combination of tebuconazole and SX. The abbreviation of "SX" indicates any one compound selected from the Present compound A. Also, the number in a parenthesis represents the CAS registration number. tebuconazole+SX, prothioconazole+SX, metconazole+SX, ipconazole+SX, triti- conazole+SX, difenoconazole+SX, imazalil+SX, triadimenol+SX, tetraconazole+SX, flutriafol+SX, bromuconazole+SX, propiconazole+SX, mefentrifluconazole+SX, ipfentrifluconazole+SX, epoxiconazole+SX, cyproconazole+SX, mandestrobin+SX, azoxystrobin+SX, pyraclostrobin+SX, trifloxystrobin+SX, fluoxastrobin+SX, pi- coxystrobin+SX, fenamidone+SX, dimoxystrobin+SX, metominostrobin+SX, pyribencarb+SX, sedaxane+SX, penflufen+SX, fluxapyroxad+SX, fluopyram+SX, benzovindiflupyr+SX, boscalid+SX, carboxin+SX, penthiopyrad+SX, flutolanil+SX, bixafen+SX, pydiflumetofen+SX, 3-difluoromethyl-N-(7-fluoro- 1,1,3-trimethylindan-4-yl)- 1-methylpyrazole-4-carboxa mide (1383809-87-7)+SX, N-cyclopropyl-3-(difluoromethyl)-5-fluoro-N-(5-chloro-2-isopropylbenzyl)-l-methyl-lH-p yrazole-4-carboxamide (1255734-28-l)+SX, 3-difluoromethyl- 1-methyl-N-( 1,1,3-trimethylindan-4-yl)pyrazole-4-carboxamide (141573-94-6)+SX, 3-difluoromethyl- 1-methyl-N- [(3R)- 1,1,3-trimethylindan-4-yl]pyrazole-4-carboxamide (1352994-67-2)+SX, metalaxyl+SX, metalaxyl-M+SX, metrafenone+SX, cyflufenamid+SX, proquinazid+SX, 3-chloro-5-phenyl-6-methyl-4-(2,6-difluorophenyl)pyridazine (135806 l-55-8)+SX,

1-(2-{[1-(4-chloropheny 1) -1H-pyrazol-3 -y1] oxymethyl }-3-methylpheny 1) -4-methy 1- 1,4 -dihydrotetrazol-5-one (1472649-01-6)+SX, 4-(2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)- 1,3-dimethyl- lH-pyrazol-5- amine (1362477-26-6)+SX, (3S,6S,7R,8R)-8-benzyl-3-[({3-[(isobutyryloxy)methoxy]-4-methoxypyridin-2-yl}carb onyl)amino]-6-methyl-4,9-dioxo-l,5-dioxonan-7-yl-2-methylpropanoate (517875-34-2)+SX, N'-(2,5-dimethyl-4-phenoxyphenyl)-N-ethyl-N-methylmethanimidamide (1052688-31-9)+SX, isotianil+SX, oxolinic acid+SX, ferimzone+SX, phthalide+SX, kasugamycin+SX, tebufloquin+SX, quinofumelin+SX, fenpyrazamine+SX, pro- cymidone+SX, fludioxonil+SX, tolclofos-methyl+SX, thiabendazole+SX, ethaboxam+SX, picarbutrazox+SX, oxathiapiprolin+SX, iminoctadine triacetate+SX, iminoctadine albesilate+SX, fenpropimorph+SX, fenpropidin+SX, spiroxamine+SX, chlorothalonil+SX, folpet+SX, captan+SX, thiram+SX, silthiofam+SX, mancozeb+SX, cartap+SX, clothianidin+SX, thiamethoxam+SX, imidacloprid+SX, thiacloprid+SX, flupyradifurone+SX, sulfoxaflor+SX, triflumezopyrim+SX, di- cloromezotiaz+SX, beta-cyfluthrin+SX, tefluthrin+SX, fipronil+SX, chlo- rantraniliprole+SX, cyantraniliprole+SX, tetraniliprole+SX, thiodicarb+SX, carbofuran+SX, fluxametamide+SX, afoxolaner+SX, fluralaner+SX, broflanilide+SX, abamectin+SX, fluensulfone+SX, fluazaindolizine+SX, tioxazafen+SX, (E)-N-{ l-[(6-chloropyridin-3-yl)methyl]pyridin-2(lH)-ylidene}-2,2,2-trifluoroacetami de (1689566-03-7)+SX, Mycorrhizal Fungi+SX, Bacillus firmus+SX, Bacillus amy- loliquefaciens+SX, Pasteuria nishizawae+SX, Pasteuria penetrans+SX. Examples of the ratio of the Present compound and the Present ingredient include, but are not limited to, 1000:1 to 1:1000, 500:1 to 1:500, 100:1 to 1:100, 50:1 to 1:50, 20:1 to 1:20, 10:1 to 1:10, 3:1 to 1:3, 1:1 to 1:500, 1:1 to 1:100, 1:1 to 1:50, 1:1 to 1:20, and 1:1 to 1:10 in the ratio by weight (Present compound:Present ingredient). [0240] Applying the Present compound to a plant achieves efficacies for promoting the plant growth such as the increase in the rate of seedling establishment, increase in the number of healthy leaves, increase in the height of the plant, increase in the weight of the plant, increase in the leaf area, increase in the number or weight of seeds or fruits, increase in the number of occasion of flower setting or fruit setting, and promoted growth of a root. Also, applying the Present compound to a plant achieves the im provement in tolerance to abiotic stresses such as temperature stresses (for example, high-temperature stress and low-temperature stress), water stresses (for example, drought stress and excess water stress), and salt stresses. [0241] Next, the Formulation examples are shown below. In the Formulation examples, the "parts" represents "parts by weight". [0242] Formulation example 1 Fifty(50) parts of any one compound of the Present compound A, 3 parts of calcium lignin sulfonate, 2 parts of magnesium lauryl sulfate, and 45 parts of synthetic hydrated silicon oxide are fully ground and mixed to obtain each formulation. [0243] Formulation example 2 Twenty(20) parts of any one compound of the Present compound A, 1.5 parts of sorbitan trioleate, and 28.5 parts of an aqueous solution comprising 2 parts of polyvinyl alcohol are mixed and finely ground by a wet grinding method, and then 40 parts of an aqueous solution comprising 0.05 parts of xanthane gum and 0.1 part of aluminum magnesium silicate are added thereto, and 10 parts of propylene glycol is further added thereto, and the resulting mixtures are mixed with stirring to obtain each formulation. [0244] Formulation example 3 Two(2) parts of any one compound of the Present compound A, 88 parts of kaolin clay, and 10 parts of talc are fully ground and mixed to obtain each formulation. [0245] Formulation example 4 Five(5) parts of any one compound of the Present compound A, 14 parts of polyoxyethylene styryl phenyl ether, 6 parts of calcium dodecylbenzenesulfonate, and 75 parts of xylene are fully mixed to obtain each formulation. [0246] Formulation example 5 Two(2) parts of any one compound of the Present compound A, 1 part of synthetic hydrated silicon oxide, 2 parts of calcium lignin sulfonate, 30 parts of bentonite, and 65 parts of kaolin clay are fully ground and mixed, and then water is added thereto, and the resulting mixture are fully kneaded, and granulated and dried to obtain each for mulation. [0247] Formulation example 6 Twenty(20) parts of any one compound of the Present compound A, 35 parts of a mixture of white carbon and polyoxyethylene alkyl ether sulfate ammonium salt (weight ratio 1:1), and water are mixed to obtain 100 parts of mixture, and the mixture is treated by a grinder to obtain each formulation. [0248] Next, Test examples are used to show efficacies of the Present compounds on con trolling pests. [0249] Test example 1: Test for controlling wheat Septoria leaf blotch (Septoria tritici) The Present compound 3, 4, 5, 11, 13, 14, 21, 45, 64, 79 to 82, 83, 85, or 90 was diluted with dimethyl sulfoxide such that each concentration of the Present compound was 1500 ppm. The resultant dilute solution was dispensed into a microtiter plate (with 96 wells) in 1 L· portion thereof per well. Thereto was then dispensed 150 of a potato dextrose broth medium (PDB medium) to which spores of wheat Septoria leaf blotch (Septoria tritici) were inoculated in advance. This plate was cultured at 18°C for five days, thereby allowing wheat Septoria leaf blotch (Septoria tritici) to undergo pro liferation, and the absorbance at 550 nm of each well of the microtiter plate was then measured, and the obtained value was used as the degree of growth of wheat Septoria leaf blotch (Septoria tritici). From the test results, each degree of growth of the group treated with the Present compound 3, 4, 5, 11, 13, 14, 21, 45, 64, 79 to 82, 83, 85, or 90 was 50% or less as compared to the degree of growth of the untreated group. [0250] Test example 2: Test for controlling tomato leaf mold (Cladosporium fulvum) The Present compound 1, 7, 13, 23, 25, 28, 31, 32, 34, 36, 39 to 45, 47, 54, 59, 61, 71, 74, 77, 79, 80 to 82, 86 to 91, or 92 was diluted with dimethyl sulfoxide such that each concentration of the Present compound was 1500 ppm. The resultant dilute solution was dispensed into a microtiter plate (with 96 wells) in 1 portion thereof per well. Thereto was then dispensed 150 of a potato dextrose broth medium (PDB medium) to which spores of tomato leaf mold (Cladosporium fulvum) (Qol resistance strain in which the base sequence of the gene encoding cytochrome b was mutated such that the amino acid residue 129 in cytochrome b was replaced from phenylalanine with leucine) were inoculated in advance. This plate was cultured at 18°C for five days, thereby allowing tomato leaf mold (Cladosporium fulvum) to undergo pro liferation, and the absorbance at 550 nm of each well of the microtiter plate was then measured, and the obtained value was used as the degree of growth of tomato leaf mold (Cladosporium fulvum). From the test results, each degree of growth of the group treated with the Present compound 1, 7, 13, 23, 25, 28, 31, 32, 34, 36, 39 to 45, 47, 54, 59, 61, 71, 74, 77, 79, 80 to 82, 86 to 91, or 92 was 50% or less as compared to the degree of growth of the untreated group. [0251] Test example 3: Test for controlling soybean rust (Phakopsora pachyrhizi) A plastic pot was filled with soil, and thereto soybeans (cultivar. Kurosengoku) were seeded, and the soybeans were cultivated in a greenhouse for ten days, and an aqueous suspension of uredospores of soybean rust (Phakopsora pachyrhizi) was inoculated by spraying thereto. After the inoculation, the soybeans were placed at 23°C in daytime and 20°C in nighttime in a greenhouse under humid condition for one day, and then cultivated in a greenhouse for two days. Separately, the Present compound 1 to 16, 18 to 37, 39, 40 to 48, 50 to 58, 60 to 77, 79 to 86, 88 to 91, or 92 formulated according to the process described in the Formulation example 6 was mixed with water such that each concentration of the Present compound was 200 ppm. Said mixture was sprayed to foliar parts so as to adhere adequately onto the surfaces of leaves of the above soybeans. After spraying the mixture, the soybeans were air-dried, and cultivated in a greenhouse for eight days, and then the lesion area was examined. From the test results, each lesion area of the group of soybeans treated with the Present compound 1 to 16, 18 to 37, 39, 40 to 48, 50 to 58, 60 to 77, 79 to 86, 88 to 91, or 92 was 30% or less as compared to the lesion area of the untreated group of soybeans. [0252] Test example 4: Test for controlling soybean rust (Phakopsora pachyrhizi) A plastic pot was filled with soil, and thereto soybeans (cultivar. Kurosengoku) were seeded, and the soybeans were cultivated in a greenhouse for thirteen days. Separately, the Present compound 1, 3 to 16, 18 to 33, 35 to 48, 50 to 77, 79, 80, 82 to 86, 88 to 91, or 92 formulated according to the process described in the Formulation example 6 was mixed with water such that each concentration of the Present compound was 200 ppm. Said mixture was sprayed to foliar parts so as to adhere adequately onto the surfaces of leaves of the above soybeans. After spraying the mixture, the soybeans were air-dried, and four days after the application, an aqueous suspension of spores of soybean rust (Phakopsora pachyrhizi) was inoculated by spraying thereto. After the in oculation, the soybeans were placed at 23°C in daytime and 20°C in nighttime in a greenhouse under humid condition for one day, and then cultivated in a greenhouse for ten days, and then the lesion area was examined. From the test results, each lesion area of the group of soybeans treated with the Present compound 1, 3 to 16, 18 to 33, 35 to 48, 50 to 77, 79, 80, 82 to 86, 88 to 91, or 92 was 30% or less as compared to the lesion area of the untreated group of soybeans. [0253] Test example 5: Test for controlling wheat Septoria leaf blotch (Septoria tritici) A plastic pot was filled with soil, and thereto wheat (cultivar. Apogee) was seeded, and the wheat was cultivated in a greenhouse for ten days. Separately, the Present compound 1, 3 to 8, 10, 13 to 24, 29, 30, 32 to 35, 39, 40, 42, 44, 49, 51, 52, 54 to 58, 60, 62 to 69, 71, 74, 77, 79 to 82, 84 to 86, 88, 89, or 90 formulated according to the process described in the Formulation example 6 was mixed with water such that each concentration of the Present compound was 500 ppm. Said mixture was sprayed to foliar parts so as to adhere adequately onto the surfaces of leaves of the above wheat. After spraying the mixture, the wheat was air-dried, and four days after the application, an aqueous suspension of spores of wheat Septoria leaf blotch (Septoria tritici) was in oculated by spraying thereto. After the inoculation, the wheat was placed at 18°C under humid condition for three days and then cultivated under lighting for fourteen to eighteen days, and then the lesion area was examined. From the test results, each lesion area of the group of wheat treated with the Present compound 1, 3 to 8, 10, 13 to 24, 29, 30, 32 to 35, 39, 40, 42, 44, 49, 51, 52, 54 to 58, 60, 62 to 69, 71, 74, 77, 79 to 82, 84 to 86, 88, 89, or 90 was 30% or less as compared to the lesion area of the untreated group of wheat. [0254] Test example 6: Test for controlling wheat Septoria leaf blotch (Septoria tritici) A plastic pot was filled with soil, and thereto wheat (cultivar. Apogee) was seeded, and the wheat was cultivated in a greenhouse for ten days. Separately, the Present compound 1, 3 to 8, 11 to 14, 16 to 31, 35 to 37, 39 to 44, 52 to 56, 58, 60 to 62, 64 to 71, 74, 77, 79 to 88, or 89 formulated according to the process described in the For mulation example 6 was mixed with water such that each concentration of the Present compound was 200 ppm. Said mixture was sprayed to foliar parts so as to adhere ad equately onto the surfaces of leaves of the above wheat. After spraying the mixture, the wheat was air-dried, and four days after the application, an aqueous suspension of spores of wheat Septoria leaf blotch (Septoria tritici) was inoculated by spraying thereto. After the inoculation, the wheat was placed at 18°C under humid condition for three days and then cultivated under lighting for fourteen to eighteen days, and then the lesion area was examined. From the test results, each lesion area of the group of wheat treated with the Present compound 1, 3 to 8, 11 to 14, 16 to 31, 35 to 37, 39 to 44, 52 to 56, 58, 60 to 62, 64 to 71, 74, 77, 79 to 88, or 89 was 30% or less as compared to the lesion area of the untreated group of wheat. [0255] Test example 7: Test for controlling wheat rust (Puccinia recondita) A plastic pot was filled with soil, and thereto wheat (cultivar. Shirogane) was seeded, and the wheat was cultivated in a greenhouse for nine days. Separately, the Present compound 1 to 8, 11, 13 to 25, 27, 29 to 36, 39, 40, 47 to 50, 52 to 69, 71, 74, 77, 79, 80 to 86, 88, 89, or 90 formulated according to the process described in the For mulation example 6 was mixed with water such that each concentration of the Present compound was 500 ppm. Said mixture was sprayed to foliar parts so as to adhere ad equately onto the surfaces of leaves of the above wheat. After spraying the mixture, the wheat was air-dried, and cultivated at 20°C under lighting for five days, and then spores of wheat rust (Puccinia recondita) were inoculated by dusting thereto. After the inoculation, the wheat was placed at 23°C under dark and humid condition for one day, and then cultivated at 20°C under lighting for eight days, and the lesion area was examined. From the test results, each lesion area of the group of wheat treated with the Present compound 1 to 8, 11, 13 to 25, 27, 29 to 36, 39, 40, 47 to 50, 52 to 69, 71, 74, 77, 79, 80 to 86, 88, 89, or 90 was 30% or less as compared to the lesion area of the untreated group of wheat. [0256] Test example 8: Test for controlling wheat rust (Puccinia recondita) A plastic pot was filled with soil, and thereto wheat (cultivar. Shirogane) was seeded, and the wheat was cultivated in a greenhouse for nine days. Separately, the Present compound 1, 3 to 8, 12 to 14, 16 to 25, 29, 30, 33, 35 to 37, 39 to 41, 43, 44, 51, 53, 55 to 58, 60 to 66, 7 1 to 74, 77, 79 to 91, or 92 formulated according to the process described in the Formulation example 6 was mixed with water such that each con centration of the Present compound was 200 ppm. Said mixture was sprayed to foliar parts so as to adhere adequately onto the surfaces of leaves of the above wheat. After spraying the mixture, the wheat was air-dried, and cultivated at 20°C under lighting for five days, and then spores of wheat rust (Puccinia recondita) were inoculated by dusting thereto. After the inoculation, the wheat was placed at 23°C under dark and humid condition for one day, and then cultivated at 20°C under lighting for eight days, and the lesion area was examined. From the test results, each lesion area of the group of wheat treated with the Present compound 1, 3 to 8, 12 to 14, 16 to 25, 29, 30, 33, 35 to 37, 39 to 41, 43, 44, 51, 53, 55 to 58, 60 to 66, 7 1 to 74, 77, 79 to 91, or 92 was 30% or less as compared to the lesion area of the untreated group of wheat. [0257] Test example 9: Test for controlling rice blast (Magnaporthe grisea) A plastic pot was filled with soil, and thereto rice (cultivar. Hinohikari) was seeded, and the rice was cultivated in a greenhouse for twenty days. Separately, the Present compound 1 to 4, 6, 7, 14, 17, 21, 39, 51, 63, 66 to 68, 71, or 82 formulated according to the process described in the Formulation example 6 was mixed with water such that each concentration of the Present compound was 500 ppm. Said mixture was sprayed to foliar parts so as to adhere adequately onto the surfaces of leaves of the above rice. After spraying the mixture, the rice was air-dried, and the above spray-treated rice was placed at 24°C in daytime and 20°C in nighttime under humid condition for six days in contact with rice seedlings (cultivar. Hinohikari) infected with rice blast (Magnaporthe grisea), and then the lesion area was examined. From the test results, each lesion area of the group of rice treated with the Present compound 1 to 4, 6, 7, 14, 17, 21, 39, 51, 63, 66 to 68, 71, or 82 was 30% or less as compared to the lesion area of the untreated group of rice. [0258] Test example 10: Test for controlling rice blast (Magnaporthe grisea) A plastic pot was filled with soil, and thereto rice (cultivar. Hinohikari) was seeded, and the rice was cultivated in a greenhouse for twenty days. Separately, the Present compound 3, 4, 15, 20, 52, 55, 63, 66 to 69, or 7 1 formulated according to the process described in the Formulation example 6 was mixed with water such that each con centration of the Present compound was 200 ppm. Said mixture was sprayed to foliar parts so as to adhere adequately onto the surfaces of leaves of the above rice. After spraying the mixture, the rice was air-dried, and the above spray-treated rice was placed at 24°C in daytime and 20°C in nighttime under humid condition for six days in contact with rice seedlings (cultivar. Hinohikari) infected with rice blast (Magnaporthe grisea), and then the lesion area was examined. From the test results, each lesion area of the group of rice treated with the Present compound 3, 4, 15, 20, 52, 55, 63, 66 to 69, or 7 1 was 30% or less as compared to the lesion area of the untreated group of rice. [0259] Test example 11: Test for controlling cucumber powdery mildew (Sphaerotheca fuliginea) A plastic pot was filled with soil, and thereto cucumbers (cultivar. Sagamihanjiro) were seeded, and the cucumbers were cultivated in a greenhouse for twelve days. Separately, the Present compound 4 or 43 formulated according to the process described in the Formulation example 6 was mixed with water such that each con centration of the Present compound was 200 ppm. Said mixture was sprayed to foliar parts so as to adhere adequately onto the surfaces of leaves of the above cucumbers. After spraying the mixture, the cucumbers were air-dried, and placed at 24°C in daytime and 20°C in nighttime in a greenhouse for one day, and then spores of cucumber seedlings (cultivar. Sagamihanjiro) infected with cucumber powdery mildew (Sphaerotheca fuliginea) were inoculated by dusting thereto. The cucumbers were cultivated at 24°C in daytime and 20°C in nighttime in a greenhouse for eight days, and then the lesion area was examined. From the test results, each lesion area of the group of cucumbers treated with the Present compound 4 or 43 was 30% or less as compared to the lesion area of the untreated group of cucumbers. [0260] Test example 12: Test for controlling barley net blotch (Pyrenophora teres) A plastic pot was filled with soil, and thereto barley (cultivar. Nishinohoshi) was seeded, and the barley was cultivated in a greenhouse for seven days. Separately, the Present compound 5, 8, 10, 15, 32, 50, 55, 61, or 7 1 formulated according to the process described in the Formulation example 6 was mixed with water such that each concentration of the Present compound was 500 ppm. Said mixture was sprayed to foliar parts so as to adhere adequately onto the surfaces of leaves of the above barley. After spraying the mixture, the barley was air-dried, and two days after the application, an aqueous suspension of spores of barley net blotch (Pyrenophora teres) was in oculated by spraying thereto. After the inoculation, the barley was placed at 23°C in daytime and 20°C in nighttime in a greenhouse under humid condition for three days, and then cultivated in a greenhouse for seven days, and then the lesion area was examined. From the test results, each lesion area of the barley treated with the Present compound 5, 8, 10, 15, 32, 50, 55, 61, or 7 1 was 30% or less as compared to the lesion area of the untreated group of barley. [0261] Test example 13 Approximately 30 heads of cotton aphid (Aphis gossypii, all stages of life) were released onto cucumber seedlings (on the developmental stage of the second true leaf) planted in a container, and the seedlings were left to stand for one day. Separately, the Present compound 15, 64, 84, or 85 formulated according to the process described in the Formulation example 6 was mixed with water such that each concentration of the Present compound was 500 ppm. Said mixed solution was sprayed to the above seedlings in a ratio of 10 mL/seedling. Five days after the application, the number of the surviving insects was investigated, and the controlling value was calculated by the following equation. Controlling value (%) = {l-(CbxTai)/(CaixTb)}xl00 wherein the symbols in the equation represent the following descriptions. Cb: Number of the test insects in untreated group Cai: Number of the surviving insects at the time of the investigation in untreated group Tb: Number of the test insects in treated group Tai: Number of the surviving insects at the time of the investigation in treated group Here the "untreated group" represents a group in which the same procedures as those made in the treated group were made except for not using the Present compound. From the test results, the treated group that was treated with the Present compound 15, 64, 84, or 85 showed 90% or greater as the controlling value. [0262] Comparative test example: Test for controlling wheat rust (Puccinia recondita) A plastic pot was filled with soil, and thereto wheat (cultivar. Shirogane) was seeded, and the wheat was cultivated in a greenhouse for nine days. N,N-dimethyl-4-[5-(trifluoromethyl)-l,2,4-oxadiazol-3-yl]benzenesulfonamide described in WO 2013/008162 pamphlet formulated according to the process described in the Formulation example 6 was mixed with water such that the concentration of the compound was 200 ppm. Said mixture was sprayed to foliar parts so as to adhere ad equately onto the surfaces of leaves of the above wheat. After spraying the mixture, the wheat was air-dried, and cultivated at 20°C under lighting for five days, and then spores of wheat rust (Puccinia recondita) were inoculated by dusting thereto. After the inoculation, the wheat was placed at 23°C under dark and humid condition for one day, and then cultivated at 20°C under lighting for eight days, and the lesion area was examined. From the test results, each lesion area of the group of wheat treated with N,N-dimethyl-4-[5-(trifluoromethyl)- 1,2,4-oxadiazol-3-yl]benzenesulfonamide was 70% or greater as compared to the lesion area of the untreated group of wheat. Industrial Applicability The compound of the present invention has excellent efficacies for controlling pests and useful as an active ingredient of an agent for controlling pests. WO 2017/213252 PCT/JP2017/021473

Claims

[Claim 1] A compound represented by formula (I): [Chem.l]

5 to 7 membered heterocyclic group may optionally have one or more substituents selected from Group D); when X is a NR6 and Y is a NR R12, R6 and R 1 1 may be combined with each other to form a 5 to 7 membered heterocyclic group (wherein said 5 to 7 membered heterocyclic group may optionally have one or more substituents selected from Group D); and when X is a NR6 and Y is a OR 13 , R6 and R13 may be combined with each other to form a 5 to 7 membered heterocyclic group (wherein said 5 to 7 membered heterocyclic group may optionally have one or more substituents selected from Group D); Group A: a group consisting of a C1-C6 alkoxy group optionally having one or more halogen atoms, a C1-C6 alkylthio group optionally having one or more halogen atoms, a C3-C6 cycloalkyl group op tionally having one or more substituents selected from Group C, a phenyl group optionally having one or more substituents selected from Group H, a 5 to 6 membered aromatic heterocyclic group optionally having one or more substituents selected from Group H, a halogen atom, a nitro group, and a cyano group; Group B: a group consisting of a C1-C6 alkylthio group optionally having one or more halogen atoms, a phenyl group optionally having one or more substituents selected from Group H, a 5 to 6 membered aromatic heterocyclic group optionally having one or more substituents selected from Group H, a halogen atom, a nitro group, and a cyano group; Group C: a group consisting of a halogen atom, a nitro group, and a cyano group; Group D: a group consisting of a C1-C6 alkyl group optionally having one or more substituents selected from Group C, a C3-C6 cycloalkyl group optionally having one or more substituents selected from Group C, a C1-C6 alkoxy group optionally having one or more halogen atoms, a C3-C6 alkenyloxy group optionally having one or more halogen atoms, a C3-C6 alkynyloxy group optionally having one or more halogen atoms, a C1-C6 alkylthio group optionally having one or more halogen atoms, a C1-C6 alkylsulfonyloxy group optionally having one or more halogen atoms, a halogen atom, a cyano group, and a nitro group; Group E: a group consisting of a C3-C6 cycloalkyl group optionally having one or more substituents selected from Group C, a C1-C6 PCT/JP2017/021473 alkoxy group optionally having one or more halogen atoms, a C1-C6 alkylthio group optionally having one or more halogen atoms, a phenyl group optionally having one or more substituents selected from Group H, a 5 to 6 membered aromatic heterocyclic group optionally having one or more substituents selected from Group H, a C1-C6 alkylsulfonyl group optionally having one or more halogen atoms, a C1-C6 alkylsulfonyloxy group optionally having one or more halogen atoms, and a halogen atom; Group F: a group consisting of a C2-C7 alkylcarbonylamino group op tionally having one or more substituents selected from Group C, a C1-C6 alkylaminocarbonyl group optionally having one or more sub stituents selected from Group C, a di(Cl-C6 alkyl)aminocarbonyl group optionally having one or more substituents selected from Group C, a C1-C6 alkylsulfonylamino group optionally having one or more substituents selected from Group C, a C1-C6 alkylaminosulfonyl group optionally having one or more substituents selected from Group C, and a di(Cl-C6 alkylaminosulfonyl group optionally having one or more substituents selected from Group C; Group G: a group consisting of a C1-C6 alkyl group optionally having one or more substituents selected from Group C, a C3-C6 cycloalkyl group optionally having one or more substituents selected from Group C, a C1-C6 alkoxy group optionally having one or more halogen atoms, a C3-C6 alkenyloxy group optionally having one or more halogen atoms, a C3-C6 alkynyloxy group optionally having one or more halogen atoms, a C1-C6 alkylthio group optionally having one or more halogen atoms, a C1-C6 alkylsulfonyloxy group optionally having one or more halogen atoms, a halogen atom, and a nitro group; Group H: a group consisting of a C1-C6 alkyl group optionally having one or more halogen atoms, a C1-C6 alkoxy group optionally having one or more halogen atoms, a halogen atom, and a cyano group; Group I: a group consisting of a C1-C6 alkyl group optionally having one or more substituents selected from Group C, a C3-C6 cycloalkyl group optionally having one or more substituents selected from Group C, a C3-C6 alkenyloxy group optionally having one or more halogen atoms, a C3-C6 alkynyloxy group optionally having one or more halogen atoms, a C1-C6 alkylthio group optionally having one or more halogen atoms, a C1-C6 alkylsulfonyloxy group optionally having one or more halogen atoms, a fluorine atom, and a cyano group]. WO 2017/213252 PCT/JP2017/021473

[Claim 2] The compound according to claim 1 wherein A is a single bond; m is 0; G is a benzene ring or a pyridine ring (wherein said benzene ring and said pyridine ring may optionally have one or more fluorine atoms); X is a single bond or a NR6; Q is an oxygen atom, a NH, a N-CN, a N-C(0)R 7, or a N-C(0)OR 7; R7 is a C1-C6 alkyl group; Y is a C3-C6 cycloalkyl group optionally having one or more halogen atoms, a phenyl group optionally having one or more halogen atoms, a CR R R10, or a NR R 12 ; R6 is a C1-C6 alkyl group (wherein said C1-C6 alkyl group may op tionally have one or more substituents selected from the group consisting of a halogen atom, a C1-C6 alkoxy group, a C1-C6 alkylthio group, a C3-C6 cycloalkyl group, and a phenyl group), a C3-C6 alkynyl group optionally having one or more halogen atoms, a C3-C6 cycloalkyl group optionally having one or more halogen atoms, a phenyl group (wherein said phenyl group may optionally have one or more substituents selected from the group consisting of a halogen atom, a C1-C6 alkyl group, and a C1-C6 alkoxy group), or a hydrogen atom; R8, R , and R10 are independently of each other a C1-C6 alkyl group op tionally having one or more halogen atoms, a phenyl group, a hydrogen atom, or a halogen atom; R 1 1 and R 12 are independently of each other a C1-C6 alkyl group or a hydrogen atom; and A is attached to said benzene ring or said pyridine ring represented by G at the para position relative to the oxadiazole ring. [Claim 3] The compound according to claim 1 wherein A is a single bond; m is 0; G is a benzene ring or a pyridine ring (wherein said benzene ring and said pyridine ring may optionally have one or more fluorine atoms); X is a single bond or a NR6; Q is an oxygen atom, a NH, or a N-CN; Y is a C3-C6 cycloalkyl group optionally having one or more halogen atoms, a CR R R10 , or a NR R 12 ; R6 is a C1-C6 alkyl group optionally having one or more halogen atoms, or a hydrogen atom; PCT/JP2017/021473

R8, R , and R 10 are independently of each other a C1-C6 alkyl group op tionally having one or more halogen atoms, or a hydrogen atom; and R 1 1 and R 12 are independently of each other a C1-C6 alkyl group (wherein said C1-C6 alkyl group may optionally have one or more substituents selected from the group consisting of a halogen atom, a C3-C6 cycloalkyl group, and a C1-C6 alkoxy group), a C3-C6 alkynyl group optionally having one or more halogen atoms, a C3-C6 cycloalkyl group optionally having one or more halogen atoms, or a hydrogen atom, or R 1 1 and R 12 are combined with each other to form a 3 to 6 membered heterocyclic group (wherein said 3 to 6 membered hete rocyclic group may optionally have one or more halogen atoms). The compound according to any one of claims 1 to 3 wherein G is a benzene ring optionally having one or more fluorine atoms; and Y is a C3-C6 cycloalkyl group optionally having one or more halogen atoms, or a CR R R 10. The compound according to any one of claims 1 to 4 wherein G is a benzene ring optionally having one or more fluorine atoms; X is a single bond; and Y is a CR R R 10 . The compound according to any one of claims 1 to 4 wherein G is a benzene ring optionally having one or more fluorine atoms; X is a NR6; n is 2; Q is an oxygen atom; and Y is a C3-C6 cycloalkyl group optionally having one or more halogen atoms, or a CR R R 10. The compound according to any one of claims 1 to 3 wherein G is a benzene ring optionally having one or more fluorine atoms; X is a single bond; n is 2; Q is an oxygen atom; and Y is a NR R 12 . An agent for controlling a pest comprising the compound according to any one of claims 1 to 7. A method for controlling a pest, the method comprising applying an effective amount of the compound according to any one of claims 1 to 7 to a plant or a soil. Use of the compound according to any one of claims 1 to 7 for con- WO 2017/213252 PCT/JP2017/021473

trolling a pest. [Claim 11] A composition comprising one or more agents selected from the group consisting of a fungicide, an insecticide, a miticide, a nematicide, a plant growth regulator, and a synergist, and the compound according to any one of claims 1 to 7. A . CLASSIFICATION O F SUBJECT MATTER INV. C07D413/04 C07D417/10 C07D271/07 A01N43/836 ADD.

According to International Patent Classification (IPC) o r t o both national classification and IPC

B . FIELDS SEARCHED Minimum documentation searched (classification system followed by classification symbols) C07D A01N

Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched

Electronic data base consulted during the international search (name of data base and, where practicable, search terms used)

EPO-Internal , WPI Data

C . DOCUMENTS CONSIDERED T O B E RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.

WO 94/05153 A (E. I . DU PONT DE NEMOURS 1-5 ,8-11 AND COMPANY) 17 March 1994 (1994-03-17) page 76; cl aims 1, 5-9

WO 2015/185485 Al (BASF) 1-11 10 December 2015 (2015-12-10) page 1, l i ne 3 - l i ne 9 ; cl aims ; exampl es

W0 2017/072247 Al (SYNGENTA PARTICI PATIONS 1-5 ,8-11 AG) 4 May 2017 (2017-05-04) page 1, l i ne 3 - l i ne 8 ; cl aims ; exampl es 1, 2 , 8-10

□ Further documents are listed in the continuation of Box C . See patent family annex.

* Special categories of cited documents : "T" later document published after the international filing date o r priority date and not in conflict with the application but cited to understand "A" document defining the general state of the art which is not considered the principle o r theory underlying the invention to be of particular relevance "E" earlier application o r patent but published o n o r after the international "X" document of particular relevance; the claimed invention cannot be filing date considered novel o r cannot b e considered to involve a n inventive "L" documentwhich may throw doubts o n priority claim(s) orwhich is step when the document is taken alone cited to establish the publication date of another citation o r other "Y" document of particular relevance; the claimed invention cannot be special reason (as specified) considered to involve a n inventive step when the document is "O" document referring to a n oral disclosure, use, exhibition o r other combined with one o r more other such documents, such combination means being obvious to a person skilled in the art "P" document published prior to the international filing date but later than the priority date claimed "&" document member of the same patent family

Date of the actual completion of the international search Date of mailing of the international search report

17 July 2017 31/07/2017

Name and mailing address of the ISA/ Authorized officer European Patent Office, P.B. 5818 Patentlaan 2 N L - 2280 HV Rijswijk Tel. (+31-70) 340-2040, Fax: (+31-70) 340-3016 Hel ps , Ian Patent document Publication Patent family Publication cited in search report date member(s) date

WO 9405153 17-03-1994 WO 2015185485 10-12-2015 AR 100770 A l 02-11-2016 AU 2015270651 A l 22-12-2016 CA 2950084 A l 10-12-2015 CN 106455572 A 22-02-2017 EP 3151669 A l 12-04-2017 US 2017144980 A l 25-05-2017 W0 2015185485 A l 10-12-2015

W0 2017072247 A l 04-05-2017 NONE