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Effective Date: Monday, August 02, 2021 Test Updates

In our continuing effort to provide you with the highest quality toxicology laboratory services available, we have compiled important changes regarding a number of tests we perform. Listed below are the types of changes that may be included in this notification, effective Monday, August 02, 2021

Test Changes - Tests that have had changes to the method/ CPT code, units of measurement, scope of analysis, reference comments, or specimen requirements.

Discontinued Tests - Tests being discontinued with alternate testing suggestions.

Please use this information to update your computer systems/records. These changes are important to ensure standardization of our mutual laboratory databases.

If you have any questions about the information contained in this notification, please call our Client Support Department at (866) 522-2206. Thank you for your continued support of NMS Labs and your assistance in implementing these changes.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. NMS Labs does not assume responsibility for billing errors due to reliance on the CPT Codes listed in this document.

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 1 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Test Name Test Method / Specimen Stability Scope Units Reference Discontinue Code Name CPT Code Req. Comments

50000U Acetaminophen Confirmation, Urine • 8646U Alprazolam and Metabolite, Urine • 52007B Confirmation, Blood • 52007U Atomoxetine Confirmation, Urine • 2111U Baclofen, Urine • Panel (Qualitative), 8620ME • Meconium 50012U Benzodiazepines Confirmation, Urine • 5641U Benzodiazepines Confirmation, Urine • 9329U Benzodiazepines Panel, Urine • 52444U Confirmation, Urine • 50013U Confirmation, Urine • 5646U Cannabinoids Confirmation, Urine • and Metabolite 52015U • Confirmation, Urine and Metabolite 52017U • Confirmation, Urine 52272U Chlorpromazine Confirmation, Urine • Chromium, Cobalt and Titanium, Fluid 10217FL • (CSA) Codeine and Metabolite - Total 8661U • (Conjugated/Unconjugated), Urine 52445U Confirmation, Urine • 52034U Donepezil Confirmation, Urine • 8705U and Metabolite, Urine • 2062U Ethylene Glycol, Urine • 52047U Flecainide Confirmation, Urine • 52049U Confirmation, Urine • 52144U Confirmation, Urine • 2143U Gabapentin, Urine • 52052U Guaifenesin Confirmation, Urine • Hydrocarbon and Oxygenated Volatiles 2321U • Panel, Urine and Metabolites - Total 8663U • (Conjugated/Unconjugated), Urine Hydromorphone - Total 8664U • (Conjugated/Unconjugated), Urine 2362U Hydroxychloroquine, Urine • 2412B Inhalants Panel, Alkane Gases, Blood • NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 2 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Test Name Test Method / Specimen Stability Scope Units Reference Discontinue Code Name CPT Code Req. Comments

2535U Lorazepam, Urine • 9444U Meperidine Screen, Urine • 2610U Meperidine and Metabolite, Urine • 8721U Meperidine and Metabolite, Urine • 52072B Confirmation, Blood • 52072SP Mescaline Confirmation, Serum/Plasma • 52072U Mescaline Confirmation, Urine • 2680B Mescaline Screen, Blood • 2679B Mescaline, Blood • 2679U Mescaline, Urine • 2720U Metaxalone, Urine • and Metabolite (Qualitative), 2760ME • Meconium Methadone and Metabolite Confirmation 5682ME • (Qualitative), Meconium 2820B Methane, Blood • 9325B Methane, Blood • 2849U Methaqualone, Urine • Methylenedioxymethamphetamine and 2585U • Metabolite, Urine 52082U Metoprolol Confirmation, Urine • 3043U Metoprolol, Urine • 3057U Midazolam as Metabolite, Urine • 3061U Milnacipran/, Urine • 3075U , Urine • 3123B Naphthalene, Blood • 3216U Nordiazepam and Metabolite, Urine • 3220U , Urine • 52091FL Confirmation, Fluid • • 52091U Olanzapine Confirmation, Urine • 3248U , Urine • 3260U Oxazepam, Urine • and Metabolite - Total 8667U • (Conjugated/Unconjugated), Urine Oxymorphone - Total 8668U • (Conjugated/Unconjugated), Urine 52096U Confirmation, Urine • NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 3 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Test Name Test Method / Specimen Stability Scope Units Reference Discontinue Code Name CPT Code Req. Comments

3400U Pentazocine, Urine • 3415U Pentoxifylline, Urine • Phenacetin and Metabolite Confirmation, 52100U • Urine 5657U Confirmation, Urine • 3974B Propane, Blood • 3990U Propoxyphene and Metabolite, Urine • 4000U Propranolol, Urine • 4040B Pyrilamine, Blood • 4040U Pyrilamine, Urine • 52112U Confirmation, Urine • 4051U Quetiapine, Urine • and Metabolite Confirmation, 52436U • Urine 4105U Risperidone and Metabolite, Urine • 4137U Salicylate, Urine • 50001U Salicylates Confirmation, Urine • 52116U Confirmation, Urine • 4197U Sildenafil and Metabolite, Urine • 4323U Temazepam and Metabolite, Urine • 4327B Terpineol, Blood • 4355B Tetrahydrofuran, Blood • 5596U Thebaine Confirmation, Urine • 4486FL Titanium, Fluid • 52127U Confirmation, Urine • 4519U Topiramate, Urine • 4535U and mCPP, Urine • 4543U Triazolam as Metabolite, Urine • 4757U Valproic Acid, Urine • 4767U and Metabolite, Urine • 52135B Xylazine Confirmation, Blood • 52135SP Xylazine Confirmation, Serum/Plasma • 52135U Xylazine Confirmation, Urine • 4815B Xylazine, Blood •

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 4 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Test Name Test Method / Specimen Stability Scope Units Reference Discontinue Code Name CPT Code Req. Comments

52138B Zolazepam Confirmation, Blood •

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 5 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes 50000U Acetaminophen Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80143): Acetaminophen Method (CPT Code) Compound Name Units Reference Comment Acetaminophen mcg/mL [Reference comment removed]

8646U Alprazolam and Metabolite, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80346): Alprazolam, Alpha-Hydroxyalprazolam Method (CPT Code) Compound Name Units Reference Comment Alpha-Hydroxyalprazolam ng/mL [Reference comment removed]

52007B Atomoxetine Confirmation, Blood

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC/MS (80338): Atomoxetine Method (CPT Code) Compound Name Units Reference Comment Atomoxetine ng/mL [Reference comment removed]

52007U Atomoxetine Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC/MS (80338): Atomoxetine Method (CPT Code) Compound Name Units Reference Comment Atomoxetine ng/mL [Reference comment removed]

2111U Baclofen, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80369): Baclofen Method (CPT Code)

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 6 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes Compound Name Units Reference Comment Baclofen mcg/mL [Reference comment removed]

8620ME Barbiturates Panel (Qualitative), Meconium

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC/MS (80345): Butabarbital, Butalbital, Amobarbital, , Secobarbital, Method (CPT Code) Compound Name Units Reference Comment Phenobarbital mcg/g [Reference comment removed]

50012U Benzodiazepines Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80339, 80347): Diazepam, Nordiazepam, Oxazepam, Temazepam, Method (CPT Code) Clobazam, Chlordiazepoxide, Lorazepam, 7-Amino Clonazepam, Alprazolam, Alpha- Hydroxyalprazolam, 1-Hydroxymidazolam, Hydroxytriazolam, Hydroxyethylflurazepam, Desalkylflurazepam, Estazolam Compound Name Units Reference Comment Temazepam ng/mL [Reference comment removed]

Chlordiazepoxide ng/mL [Reference comment removed]

Estazolam ng/mL [Reference comment removed]

5641U Benzodiazepines Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80339, 80347): Diazepam, Nordiazepam, Oxazepam, Temazepam, Method (CPT Code) Clobazam, Chlordiazepoxide, Lorazepam, 7-Amino Clonazepam, Alprazolam, Alpha- Hydroxyalprazolam, 1-Hydroxymidazolam, Hydroxytriazolam, Hydroxyethylflurazepam, Desalkylflurazepam, Estazolam Compound Name Units Reference Comment Estazolam ng/mL [Reference comment removed]

9329U Benzodiazepines Panel, Urine

Summary of Changes: Reference Comment was changed.

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 7 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes Scope of Analysis: LC-MS/MS (80339, 80347): Diazepam, Nordiazepam, Oxazepam, Temazepam, Method (CPT Code) Clobazam, Chlordiazepoxide, Lorazepam, 7-Amino Clonazepam, Alprazolam, Alpha- Hydroxyalprazolam, 1-Hydroxymidazolam, Hydroxytriazolam, Hydroxyethylflurazepam, Desalkylflurazepam, Estazolam Compound Name Units Reference Comment Estazolam ng/mL [Reference comment removed]

52444U Buspirone Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80375): Buspirone Method (CPT Code) Compound Name Units Reference Comment Buspirone ng/mL [Reference comment removed]

50013U Cannabinoids Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80349): Delta-9 Carboxy THC - Total Method (CPT Code) Compound Name Units Reference Comment Delta-9 Carboxy THC - Total ng/mL [Reference comment removed]

5646U Cannabinoids Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80349): Delta-9 Carboxy THC - Total Method (CPT Code) Compound Name Units Reference Comment Delta-9 Carboxy THC - Total ng/mL [Reference comment removed]

52015U Carbamazepine and Metabolite Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80156, 80161): Carbamazepine-10,11-Epoxide, Carbamazepine Method (CPT Code) Compound Name Units Reference Comment Carbamazepine-10,11-Epoxide mcg/mL [Reference comment removed]

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 8 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes 52017U Carisoprodol and Metabolite Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC/MS (80369): Carisoprodol, Method (CPT Code) Compound Name Units Reference Comment Meprobamate mcg/mL [Reference comment removed]

52272U Chlorpromazine Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (80342): Chlorpromazine Method (CPT Code) Compound Name Units Reference Comment Chlorpromazine ng/mL [Reference comment removed]

10217FL Chromium, Cobalt and Titanium, Fluid (CSA)

Summary of Changes: Specimen Requirements were changed.

Specimen Requirements: 2 mL Fluid Transport Temperature: Refrigerated Specimen Container: Plastic container (Acid washed or Trace metal-free) Light Protection: Not Required Special Handling: None Rejection Criteria: None 8661U Codeine and Metabolite - Total (Conjugated/Unconjugated), Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80361): Codeine - Total, - Total Method (CPT Code) Compound Name Units Reference Comment Morphine - Total ng/mL [Reference comment removed]

52445U Cyclobenzaprine Confirmation, Urine

Summary of Changes: Reference Comment was changed.

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 9 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes Scope of Analysis: LC-MS/MS (80369): Cyclobenzaprine Method (CPT Code) Compound Name Units Reference Comment Cyclobenzaprine ng/mL [Reference comment removed]

52034U Donepezil Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80375): Donepezil Method (CPT Code) Compound Name Units Reference Comment Donepezil ng/mL [Reference comment removed]

8705U Doxepin and Metabolite, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC & GC/MS (80335): Doxepin, Desmethyldoxepin Method (CPT Code) Compound Name Units Reference Comment Desmethyldoxepin ng/mL [Reference comment removed]

2062U Ethylene Glycol, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (82693): Ethylene Glycol Method (CPT Code) Compound Name Units Reference Comment Ethylene Glycol mg/dL [Reference comment removed]

52047U Flecainide Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80181): Flecainide Method (CPT Code) Compound Name Units Reference Comment Flecainide mcg/mL [Reference comment removed]

52049U Fluvoxamine Confirmation, Urine

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 10 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (80332): Fluvoxamine Method (CPT Code) Compound Name Units Reference Comment Fluvoxamine ng/mL [Reference comment removed]

52144U Gabapentin Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80355): Gabapentin Method (CPT Code) Compound Name Units Reference Comment Gabapentin mcg/mL [Reference comment removed]

2143U Gabapentin, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80355): Gabapentin Method (CPT Code) Compound Name Units Reference Comment Gabapentin mcg/mL [Reference comment removed]

52052U Guaifenesin Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80375): Guaifenesin Method (CPT Code) Compound Name Units Reference Comment Guaifenesin mcg/mL [Reference comment removed]

2321U Hydrocarbon and Oxygenated Volatiles Panel, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: Headspace GC (84600): n-Butanol, Ethanol, Isopropanol, n-Propanol, Methanol, Method (CPT Code) Acetone, Isobutanol, Tert-Butanol, Tetrahydrofuran, Iso-Amyl , Sec-Butanol Compound Name Units Reference Comment Tert-Butanol mcg/mL [Reference comment removed]

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 11 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes 8663U Hydrocodone and Metabolites - Total (Conjugated/Unconjugated), Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80361): Dihydrocodeine / Hydrocodol - Total, Hydrocodone - Total, Method (CPT Code) Hydromorphone - Total Compound Name Units Reference Comment Dihydrocodeine / Hydrocodol - ng/mL [Reference comment removed] Total 8664U Hydromorphone - Total (Conjugated/Unconjugated), Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80361): Hydromorphone - Total Method (CPT Code) Compound Name Units Reference Comment Hydromorphone - Total ng/mL [Reference comment removed]

2362U Hydroxychloroquine, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80375): Hydroxychloroquine Method (CPT Code) Compound Name Units Reference Comment Hydroxychloroquine ng/mL [Reference comment removed]

2412B Inhalants Panel, Alkane Gases, Blood

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (84600): Methane, Ethane, Propane, Isobutane, n- Method (CPT Code) Compound Name Units Reference Comment n-Butane ppm (v/v) [Reference comment removed]

2535U Lorazepam, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80346): Lorazepam Method (CPT Code)

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 12 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes Compound Name Units Reference Comment Lorazepam ng/mL [Reference comment removed]

9444U Meperidine Screen, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: EIA (80307): Meperidine Method (CPT Code) Compound Name Units Reference Comment Meperidine mcg/mL [Reference comment removed]

2610U Meperidine and Metabolite, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (80362): Meperidine, Normeperidine Method (CPT Code) Compound Name Units Reference Comment Normeperidine mcg/mL [Reference comment removed]

8721U Meperidine and Metabolite, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC & GC/MS (80362): Meperidine, Normeperidine Method (CPT Code) Compound Name Units Reference Comment Meperidine mcg/mL [Reference comment removed]

Normeperidine mcg/mL [Reference comment removed]

52072B Mescaline Confirmation, Blood

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (80323): Mescaline Method (CPT Code) Compound Name Units Reference Comment Mescaline mcg/mL [Reference comment removed]

52072SP Mescaline Confirmation, Serum/Plasma

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 13 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (80323): Mescaline Method (CPT Code) Compound Name Units Reference Comment Mescaline mcg/mL [Reference comment removed]

52072U Mescaline Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (80323): Mescaline Method (CPT Code) Compound Name Units Reference Comment Mescaline mcg/mL [Reference comment removed]

2680B Mescaline Screen, Blood

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (80307): Mescaline Method (CPT Code) Compound Name Units Reference Comment Mescaline mcg/mL [Reference comment removed]

2679B Mescaline, Blood

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (80323): Mescaline Method (CPT Code) Compound Name Units Reference Comment Mescaline mcg/mL [Reference comment removed]

2679U Mescaline, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (80323): Mescaline Method (CPT Code) Compound Name Units Reference Comment Mescaline mcg/mL [Reference comment removed]

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 14 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes 2720U Metaxalone, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80369): Metaxalone Method (CPT Code) Compound Name Units Reference Comment Metaxalone mcg/mL [Reference comment removed]

2760ME Methadone and Metabolite (Qualitative), Meconium

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80358): Methadone, EDDP Method (CPT Code) Compound Name Units Reference Comment EDDP ng/g [Reference comment removed]

5682ME Methadone and Metabolite Confirmation (Qualitative), Meconium

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80358): Methadone, EDDP Method (CPT Code) Compound Name Units Reference Comment EDDP ng/g [Reference comment removed]

2820B Methane, Blood

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (84600): Methane Method (CPT Code) Compound Name Units Reference Comment Methane ppm (v/v) [Reference comment removed]

9325B Methane, Blood

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC/MS (84600): Methane Method (CPT Code)

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 15 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes Compound Name Units Reference Comment Methane mcg/mL [Reference comment removed]

2849U Methaqualone, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC/MS (80368): Methaqualone Method (CPT Code) Compound Name Units Reference Comment Methaqualone mcg/mL [Reference comment removed]

2585U Methylenedioxymethamphetamine and Metabolite, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80359): MDA, MDMA Method (CPT Code) Compound Name Units Reference Comment MDMA ng/mL [Reference comment removed]

52082U Metoprolol Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80375): Metoprolol Method (CPT Code) Compound Name Units Reference Comment Metoprolol ng/mL [Reference comment removed]

3043U Metoprolol, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80375): Metoprolol Method (CPT Code) Compound Name Units Reference Comment Metoprolol ng/mL [Reference comment removed]

3057U Midazolam as Metabolite, Urine

Summary of Changes: Reference Comment was changed.

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 16 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes Scope of Analysis: LC-MS/MS (80346): 1-Hydroxymidazolam Method (CPT Code) Compound Name Units Reference Comment 1-Hydroxymidazolam ng/mL [Reference comment removed]

3061U Milnacipran/Levomilnacipran, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80332): Milnacipran/Levomilnacipran Method (CPT Code) Compound Name Units Reference Comment Milnacipran/Levomilnacipran ng/mL [Reference comment removed]

3075U Mirtazapine, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (80335): Mirtazapine Method (CPT Code) Compound Name Units Reference Comment Mirtazapine ng/mL [Reference comment removed]

3123B Naphthalene, Blood

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (82542): Naphthalene Method (CPT Code) Compound Name Units Reference Comment Naphthalene mcg/mL [Reference comment removed]

3216U Nordiazepam and Metabolite, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80346): Nordiazepam, Oxazepam Method (CPT Code) Compound Name Units Reference Comment Oxazepam ng/mL [Reference comment removed]

3220U Nortriptyline, Urine

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 17 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (80335): Nortriptyline Method (CPT Code) Compound Name Units Reference Comment Nortriptyline ng/mL [Reference comment removed]

52091FL Olanzapine Confirmation, Fluid

Summary of Changes: Test Name was changed. Reference Comment was changed. Scope of Analysis: LC-MS/MS (80342): Olanzapine Method (CPT Code) Compound Name Units Reference Comment Olanzapine ng/mL [Reference comment removed]

52091U Olanzapine Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80342): Olanzapine Method (CPT Code) Compound Name Units Reference Comment Olanzapine ng/mL [Reference comment removed]

3248U Orphenadrine, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (80369): Orphenadrine Method (CPT Code) Compound Name Units Reference Comment Orphenadrine ng/mL [Reference comment removed]

3260U Oxazepam, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80346): Oxazepam Method (CPT Code)

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 18 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes Compound Name Units Reference Comment Oxazepam ng/mL [Reference comment removed]

8667U Oxycodone and Metabolite - Total (Conjugated/Unconjugated), Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80365): Oxycodone - Total, Oxymorphone - Total Method (CPT Code) Compound Name Units Reference Comment Oxymorphone - Total ng/mL [Reference comment removed]

8668U Oxymorphone - Total (Conjugated/Unconjugated), Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80365): Oxymorphone - Total Method (CPT Code) Compound Name Units Reference Comment Oxymorphone - Total ng/mL [Reference comment removed]

52096U Paroxetine Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80332): Paroxetine Method (CPT Code) Compound Name Units Reference Comment Paroxetine ng/mL [Reference comment removed]

3400U Pentazocine, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (80362): Pentazocine Method (CPT Code) Compound Name Units Reference Comment Pentazocine ng/mL [Reference comment removed]

3415U Pentoxifylline, Urine

Summary of Changes: Reference Comment was changed.

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 19 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes Scope of Analysis: LC-MS/MS (80375): Pentoxifylline Method (CPT Code) Compound Name Units Reference Comment Pentoxifylline mcg/mL [Reference comment removed]

52100U Phenacetin and Metabolite Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80143, 80329): Phenacetin, Acetaminophen Method (CPT Code) Compound Name Units Reference Comment Acetaminophen mcg/mL [Reference comment removed]

5657U Phencyclidine Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (83992): Phencyclidine Method (CPT Code) Compound Name Units Reference Comment Phencyclidine ng/mL [Reference comment removed]

3974B Propane, Blood

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (84600): Propane Method (CPT Code) Compound Name Units Reference Comment Propane ppm (v/v) [Reference comment removed]

3990U Propoxyphene and Metabolite, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC/MS (80367): Propoxyphene, Norpropoxyphene Method (CPT Code) Compound Name Units Reference Comment Norpropoxyphene mcg/mL [Reference comment removed]

4000U Propranolol, Urine

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 20 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80375): Propranolol Method (CPT Code) Compound Name Units Reference Comment Propranolol ng/mL [Reference comment removed]

4040B Pyrilamine, Blood

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (80375): Pyrilamine Method (CPT Code) Compound Name Units Reference Comment Pyrilamine ng/mL [Reference comment removed]

4040U Pyrilamine, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (80375): Pyrilamine Method (CPT Code) Compound Name Units Reference Comment Pyrilamine ng/mL [Reference comment removed]

52112U Quetiapine Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80342): Quetiapine Method (CPT Code) Compound Name Units Reference Comment Quetiapine ng/mL [Reference comment removed]

4051U Quetiapine, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80342): Quetiapine Method (CPT Code) Compound Name Units Reference Comment Quetiapine ng/mL [Reference comment removed]

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 21 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes 52436U Risperidone and Metabolite Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80342): Risperidone, 9-Hydroxyrisperidone, Risperidone and 9- Method (CPT Code) Hydroxyrisperidone - Total Compound Name Units Reference Comment Risperidone and 9- ng/mL [Reference comment removed] Hydroxyrisperidone - Total 4105U Risperidone and Metabolite, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80342): Risperidone, 9-Hydroxyrisperidone, Risperidone and 9- Method (CPT Code) Hydroxyrisperidone - Total Compound Name Units Reference Comment Risperidone and 9- ng/mL [Reference comment removed] Hydroxyrisperidone - Total 4137U Salicylate, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80179): Salicylate Method (CPT Code) Compound Name Units Reference Comment Salicylate mcg/mL [Reference comment removed]

50001U Salicylates Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80179): Method (CPT Code) Compound Name Units Reference Comment Salicylate mcg/mL [Reference comment removed]

52116U Sertraline Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (80332): Sertraline Method (CPT Code)

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 22 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes Compound Name Units Reference Comment Sertraline ng/mL [Reference comment removed]

4197U Sildenafil and Metabolite, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80375): Sildenafil, N-Desmethylsildenafil Method (CPT Code) Compound Name Units Reference Comment N-Desmethylsildenafil ng/mL [Reference comment removed]

4323U Temazepam and Metabolite, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80346): Oxazepam, Temazepam Method (CPT Code) Compound Name Units Reference Comment Temazepam ng/mL [Reference comment removed]

4327B Terpineol, Blood

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (82542): Terpineol Method (CPT Code) Compound Name Units Reference Comment Terpineol mcg/mL [Reference comment removed]

4355B Tetrahydrofuran, Blood

Summary of Changes: Reference Comment was changed.

Scope of Analysis: Headspace GC (82542): Tetrahydrofuran Method (CPT Code) Compound Name Units Reference Comment Tetrahydrofuran mcg/mL [Reference comment removed]

5596U Thebaine Confirmation, Urine

Summary of Changes: Reference Comment was changed.

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Test Changes Scope of Analysis: GC/MS (80375): Thebaine Method (CPT Code) Compound Name Units Reference Comment Thebaine ng/mL [Reference comment removed]

4486FL Titanium, Fluid

Summary of Changes: Specimen Requirements were changed.

Specimen Requirements: 2 mL Fluid Transport Temperature: Refrigerated Specimen Container: Plastic container (Acid washed or Trace metal-free) Light Protection: Not Required Special Handling: None Rejection Criteria: None 52127U Topiramate Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80201): Topiramate Method (CPT Code) Compound Name Units Reference Comment Topiramate ng/mL [Reference comment removed]

4519U Topiramate, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80201): Topiramate Method (CPT Code) Compound Name Units Reference Comment Topiramate ng/mL [Reference comment removed]

4535U Trazodone and mCPP, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80338, 80371): mCPP, Trazodone Method (CPT Code) Compound Name Units Reference Comment Trazodone mcg/mL [Reference comment removed]

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 24 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes 4543U Triazolam as Metabolite, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80346): Hydroxytriazolam Method (CPT Code) Compound Name Units Reference Comment Hydroxytriazolam ng/mL [Reference comment removed]

4757U Valproic Acid, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80164): Valproic Acid Method (CPT Code) Compound Name Units Reference Comment Valproic Acid mcg/mL [Reference comment removed]

4767U Venlafaxine and Metabolite, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80338): Venlafaxine, O-Desmethylvenlafaxine Method (CPT Code) Compound Name Units Reference Comment O-Desmethylvenlafaxine ng/mL [Reference comment removed]

52135B Xylazine Confirmation, Blood

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80375): Xylazine Method (CPT Code) Compound Name Units Reference Comment Xylazine ng/mL [Reference comment removed]

52135SP Xylazine Confirmation, Serum/Plasma

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80375): Xylazine Method (CPT Code)

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 25 of 26 Effective Date: Monday, August 02, 2021 Test Updates

Test Changes Compound Name Units Reference Comment Xylazine ng/mL [Reference comment removed]

52135U Xylazine Confirmation, Urine

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80375): Xylazine Method (CPT Code) Compound Name Units Reference Comment Xylazine ng/mL [Reference comment removed]

4815B Xylazine, Blood

Summary of Changes: Reference Comment was changed.

Scope of Analysis: LC-MS/MS (80375): Xylazine Method (CPT Code) Compound Name Units Reference Comment Xylazine ng/mL [Reference comment removed]

52138B Zolazepam Confirmation, Blood

Summary of Changes: Reference Comment was changed.

Scope of Analysis: GC (80368): Zolazepam Method (CPT Code) Compound Name Units Reference Comment Zolazepam mcg/mL [Reference comment removed]

NMS Labs 200 Welsh Rd. Horsham, PA 19044-2208 [email protected] Page 26 of 26