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Annual Technical Report 2015 Annual technical report 2015 Department of Reproductive Health and Research UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP) 2015 For more information, please contact: Department of Reproductive Health and Research World Health Organization Avenue Appia 20, CH-1211 Geneva 27, Switzerland Fax: +41 22 791 4171 E-mail: [email protected] www.who.int/reproductivehealth Department of Reproductive Health and Research, including the UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP) Annual Technical Report, 2015 WHO/RHR/HRP/16.08 UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP). Annual Technical Report 2015 © World Health Organization 2016 All rights reserved. Publications of the World Health Organization are available on the WHO website (www.who.int) or can be purchased from WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail: [email protected]). Requests for permission to reproduce or translate WHO publications –whether for sale or for non-com- mercial distribution– should be addressed to WHO Press through the WHO website (www.who.int/about/ licensing/copyright_ form/en/index.html). The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted and dashed lines on maps represent approximate border lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distin- guished by initial capital letters. All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either expressed or implied. The responsibility for the interpretation and use of the material lies with the reader. In no event shall the World Health Organization be liable for damages arising from its use. Editing: Green Ink (www.greenink.co.uk) Layout: Oceans Translations (www.oceanstranslations.com) Cover photo: Harsha KR licensed under CC by 2.0 Printed by the WHO Document Production Services, Geneva, Switzerland Table of contents Acronyms and abbreviations v 1. Introduction 1 2. High-level advocacy and input to global initiatives for sexual and reproductive health 3 3. Thematic areas 15 3.1 Family planning and contraception 15 3.2 Adolescent sexual and reproductive health 34 3.3 Maternal and perinatal health 48 3.4 Preventing unsafe abortion 87 3.5 Sexually transmitted infections and reproductive tract infections; SRH–HIV linkages and multipurpose prevention technologies 100 3.6 Cervical cancer 117 3.7 Violence against women and harmful practices, including female genital mutilation and early marriage 124 3.8 Sexual and reproductive health in humanitarian settings 135 3.9 Infertility 141 3.10 Sexual Health 146 4. Cross-cutting topics 151 4.1 Human rights and gender equality 151 4.2 Innovations 154 4.3 Biostatistics and data management 161 4.4 Advocacy and communications 166 4.5 Research project review through RP2 176 5. Research capacity strengthening, including the HRP Alliance 179 Annex A. HRP results report 2014–2015 (provisional expenditure data) 188 Annex B. Indicator report 212 Annex C. Donors 2014-2015 242 Acronyms and abbreviations v Acronyms and abbreviations ACS antenatal corticosteroids AGH Adolescents and at-Risk Populations (team within RHR/HRP) AHEAD Adolescent Health Experience after Abortion or Delivery (trial) ALIRH Latin American Association of Researchers in Human Reproduction AMR antimicrobial resistance ANC antenatal care ARMADILLO Adolescent/Youth Reproductive Mobile Access and Delivery Initiative for Love and Life Outcomes ARV antiretroviral ASRH adolescent sexual and reproductive health ASRM American Society for Reproductive Medicine AST antimicrobial susceptibility testing BOLD Better Outcomes in Labour Difficulty (project) BSC brief sexuality-related communication CDC United States Centers for Disease Control and Prevention CEFM child, early and forced marriage CEPEP The Centre for Population Studies, Asunción, Paraguay CERCA Community-embedded reproductive health care for adolescents (project) CERQual Confidence in the Evidence from Reviews of Qualitative research tool CESCR Committee on Economic, Social and Cultural Rights CIDES-UMSA The Centre for Research in Development Sciences of San Andrés University, La Paz, Bolivia CIRE Continuous Identification of Research Evidence CoIA Commission on Information and Accountability for Women’s and Children’s Health CONSORT Consolidated Standards of Reporting Trials CRVS civil registration and vital statistics DECIDE Developing and Evaluating Communication Strategies to Support Informed Decisions and Practice Based on Evidence framework DHS Demographic and Health Survey DMPA depot medroxyprogesterone acetate DSMB Data Safety and Monitoring Board EBOV Ebola virus EC emergency contraception ECOWAS Economic Community of West African States EMTCT elimination of mother-to-child transmission EPMM Ending Preventable Maternal Mortality (strategy) ERC see WHO-ERC vi Annual Technical Report 2015 EtD Evidence to Decision (framework) EVD Ebola virus disease FGM female genital mutilation FIGO International Federation of Gynecology and Obstetrics FP2020 Family Planning 2020 (an outcome of the 2012 London Summit on Family Planning) GAP gentle assisted pushing GAPP Global Abortion Policies Project GARPR Global AIDS Response Progress Reporting System GASP Gonococcal Antimicrobial Surveillance Programme Gavi Gavi – The Vaccine Alliance (formerly the Global Alliance for Vaccines and Immunization) GBV gender-based violence GDG Guideline Development Group GEAS Global Early Adolescent Study GFF Global Financing Facility GIZ Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ) GmbH GLASS Global AMR Surveillance System GRADE Grading Recommendations, Assessment, Development and Evaluation GREAT Guideline-driven, Research priorities, Evidence synthesis, Application of evidence, Network and Transfer of knowledge GRC Guidelines Review Committee GVAC Global Validation Advisory Committee H4+ UNFPA, UNICEF, WHO, The World Bank, UNAIDS, UN Women HPV human papillomavirus HRP UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction; also: Human Reproduction Programme HSV herpes simplex virus IAEA International Atomic Energy Agency IARC International Agency for Research on Cancer IAS International AIDS Society IBP Implementing Best Practices ICD International Statistical Classification of Diseases and Related Health Problems ICD-MM WHO Application of ICD-10 to deaths during pregnancy, childbirth and the puerperium (ICD-Maternal Mortality) ICD-PM WHO Application of ICD-10 to perinatal deaths (ICD-Perinatal Mortality) ICFP International Conference on Family Planning ICPD International Conference on Population and Development ICT information and communication technology IEC information, education and communication iEtD interactive Evidence-to-Decision (tool) Acronyms and abbreviations vii IFFS International Federation of Fertility Societies IMPT Initiative for Multipurpose Prevention Technologies INGO international nongovernmental organization IPPF International Planned Parenthood Federation IPU Inter-Parliamentary Union IRB Institutional Review Board IRP Implementation Research Platform IUD intrauterine device IVB Immunization, Vaccines and Biologicals (WHO Department) IWG Innovation Working Group KG Knowledge Gateway LBC liquid-based cytology LID Long-term Institutional Development (grant) LMIC low- and middle-income countries LNG levonorgestrel M&E monitoring and evaluation MAPS mHealth for Assessment and Planning for Scale (toolkit) MCA Maternal, Newborn, Child and Adolescent Health (WHO Department) MCS multicountry survey MDG Millennium Development Goal MEC Medical eligibility criteria for contraceptive use MHTF Maternal Health Task Force MISP Minimum Initial Service Package MMEIG Maternal Mortality Estimation Interagency Group MMWG Maternal Morbidity Working Group MOH ministry of health MPA medroxyprogesterone acetate MPT multipurpose prevention technology MSI Marie Stopes International MSM men who have sex with men mTERG Technical and Evidence Review Group on mHealth for RMNCH NET-EN norethisterone enanthate NGO nongovernmental organization NIH United States National Institutes of Health NVI Noncommunicable Diseases, Disability, Violence and Injury Prevention (WHO Department) OCHA United Nations Office for the Coordination of Humanitarian Affairs OpenSRP Open Smart Register Platform PAC Project Advisory Committee PAHO Pan American Health Organization PCC Policy and Coordination Committee viii Annual Technical Report 2015 PICO population, intervention, comparator and outcome PLISSER Latin American Program of Research in Sexual and
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