Spermatozoon

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Male Reproductive System components • Internal genital organs Testes Genital ducts Accessory glands • External genital organs testis General structure of testis • Capsule 鞘膜脏层 Mediastinum testis(睾丸纵隔) • Parenchyma(实质) Seminiferous tubule Tubulus rectus Rete testis Interstitial tissue Seminiferous tubule • Spermatogenic epithelium • Basement membrane • Myoid cell Spermatogenic epithelium • Spermatogenic cell (1)spermatogonium (2)primary spermatocyte (3)secondary spermatocyte (4)spermatid (5)spermatozoon • Sustentacular cell spermatogonium • On the basement membrane • Divided into A type and B type • A type cell: stem cell • B type cell: differentiation cell A type cell A type cell B type cell Primary spermatocyte • From spermatogonium • Large and round • Chromosome number: 46,2n • DNA number:4N Secondary spermatocyte • rare in section, smaller than primary spermatocyte, dark nuclei • Chromosome number:23,n • DNA:2N Spermatid • Small cells with dark nucler • Chromosome number: 23,n • DNA number: N spermatozoon spermatozoon • Have head and tail. • Chromosome number: 23,n • DNA number:N spermioginesis • Definition: spermatid→spermatozoon Structure of spermatozoon • The head of spermatozoon: Nucleus Acrosome Structure of spermatozoon • Tail of spermtozoon Neck Middle piece Principal piece End piece spermatogenesis Definition: spermatogonium→spermatozoon Sustentacular cell Sustentacular cell • LM structure pyramidal cells large ovoid nuclei with prominent nucleolus Sustentacular cell • EM structure (1)SEM,Golgi complex,mitochondria and ERE (2)tight junction between Sertoli cells Function of sustentacular cells • Physical support for the spermatogenic cells • Phagocytosis of residual bodies • Nutritional regulation • Secretion:ABP • Protection Blood-testis barrier • Capillary endothelium • Basement membrane • Connective tissue • Basement membrane • Tight junction Interstitial tissue • Testicular interstitial cell (Leydig cell) • Secrete androgen head body tail epididymis epididymis Dfferent duct Epididymal duct Function of epididymis • Make sperm maturated • Protect sperm in epididymis:blood- epidimis barrier .

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Identification of Differentially Expressed Genes of Primary
Cell Research (2004); 14(6):507-512 ARTICLE http://www.cell-research.com Identification of differentially expressed genes of primary spermatocyte against round spermatid isolated from human testis using the laser capture microdissection technique Gang LIANG1,4, Xiao Dong ZHANG1, Lu Jing WANG1, Yu Shen SHA2, Jian Chao ZHANG2, Shi Ying MIAO1, Shu Dong ZONG2, Lin Fang WANG1,*, S.S. KOIDE3 1National Laboratory Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, 5 Dong Dan San Tiao, 100005 Beijing, China 2National Research Institute for Family Planning, WHO Collaboration Center for Research in Human Reproduction, Beijing, 12 Da Hui Si, 100081 Beijing, China 3Center for Biomedical Research, Population Council, 1230 York Avenue, New York, NY 10021, USA 4Chinese National Human Genome Center, Beijing, 3-707 North Yong Chang Road BDA, Beijing 100176, China ABSTRACT The method of laser capture microdissection (LCM) combined with suppressive subtractive hybridization (SSH) was developed to isolate specific germ cells from human testis sections and to identify the genes expressed during differen- tiation and development. In the present study, over 10,000 primary spermatocytes and round spermatid cells were successfully isolated by LCM. Using the cDNAs from primary spermatocytes and round spermatids, SSH cDNAs library of primary spermatocyte-specific was constructed. The average insert size of the cDNA isolated from 75 randomly picked white clones was 500 bp, ranging from 250 bp to 1.7 kb. Using the dot-blot method, a total of 421 clones were examined, resulting in the identification of 390 positive clones emitting strong signals.
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