DOCSLIB.ORG

HM-08-026 Appendix B

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
HM-08-026 Appendix B Appendix B to HM-08-026 UNIVERSITY OF TOLEDO LABORATORY SAFETY AND HEALTH MANUAL AND INSTITUTIONAL CHEMICAL HYGIENE PLAN Environmental Health and Radiation Safety Department Effective Date: 07/01/1995 Revised: 12/20/05 2/23/09 2/1/10 6/28/10 2/1/11 2/1/12 4/10/12 2/1/2013 2/1/2014 1/30/15 1/29/16 1/27/17 1/25/18 1/22/19 1/20/20 1/20/21 EMERGENCY PHONE NUMBERS: Fire Pull Station / 911 Hazardous Matrerials Spills 419-530-2600 (MC) or 419-383-2600 (HSC) Environmental Health and Radiation Safety Department 419-530-3600 Radiation Safety Office 419-383-4301 TABLE OF CONTENTS SECTION I - FORWARD .................................................................................................................................................................. 3 SECTION II - PUBLIC EMPLOYEES RISK REDUCTION PROGRAM (PERRP) OSHA ................................................................. 4 SECTION III - LAB EQUIPMENT ..................................................................................................................................................... 5 SECTION IV - GENERAL SAFETY GUIDELINES…………………………………………………………………………………………..11 A. GENERAL PROCEDURES AND PRECAUTIONS FOR WORKING WITH SUBSTANCES OF MODERATE CHRONIC OR ACUTE HIGH TOXICITY* ....................................................................................................... 10 B. GENERAL PROCEDURES AND PRECAUSTIONS FOR WORKING WITH ALLERGENS AND EMBRYOTOXINS ........................................................................................................................................... 11 C. GENERAL PROCEDURES AND PRECAUSTIONS FOR WORKING WITH CHEMICALS OF HIGH CHRONIC TOXICITY INCLUDING CARCONOGENS ................................................................................... 12 D. GENERAL PROCEDURES AND PRECAUSTIONS FOR ANIMAL WORK WITH CHEMICALS OF HIGH CHRONIC TOXICITY ...................................................................................................................................... 12 E. RECORDKEEPING ......................................................................................................................................... 12 F. LAB SURVEYS ............................................................................................................................................... 14 G. MEDICAL SURVEILLANCE ............................................................................................................................ 15 H. TRAINING ....................................................................................................................................................... 15 SECTION V - HAZARDOUS CHEMICALS ..................................................................................................................................... 16 SECTION VI - HEALTH HAZARDS ................................................................................................................................................ 18 SECTION VII - PHYSICAL HAZARDS ........................................................................................................................................... 19 A. FLAMMABLE/COMBUSTIBLE MATERIALS .................................................................................................. 19 B. CORROSIVES ................................................................................................................................................ 20 C. OXIDIZERS ..................................................................................................................................................... 21 D. WATER REACTIVE MATERIALS ................................................................................................................... 22 E. PYROPHORIC MATERIALS ........................................................................................................................... 23 F. PEROXIDIZABLES ......................................................................................................................................... 24 G. SHOCK SENSITIVE/EXPLOSIVE MATERIALS ............................................................................................. 24 H. COMPRESSED GASES ................................................................................................................................. 25 I. LIGHT SENSITIVE MATERIALS .................................................................................................................... 27 J. CRYOGENS .................................................................................................................................................... 27 SECTION VIII - CARCINOGENS ................................................................................................................................................... 29 SECTION IX - RADIOACTIVE MATERIALS................................................................................................................................... 32 SECTION X - BIOHAZARDS .......................................................................................................................................................... 33 SECTION XI - ASBESTOS ............................................................................................................................................................. 34 SECTION XII - SOLVENTS ............................................................................................................................................................ 35 SECTION XIII - SAFETY DATA SHEETS AND OTHER REFERENCE ......................................................................................... 36 SECTION XIV - LABELING ............................................................................................................................................................ 37 SECTION XV - INDUSTRIAL TOXICOLOGY ................................................................................................................................. 39 A. DOSE-RESPONSE RELATIONSHIPS ........................................................................................................... 39 B. ROUTES OF ENTRY INTO THE BODY ......................................................................................................... 39 C. TYPES OF TOXICITY ..................................................................................................................................... 39 D. OTHER FACTORS AFFECTING TOXICITY................................................................................................... 40 E. PHYSICAL CLASSIFICATIONS OF TOXIC MATERIALS .............................................................................. 40 F. GENOTOXIC EFFECTS ................................................................................................................................. 41 G. TARGET ORGAN EFFECTS .......................................................................................................................... 41 H. OTHER EFFECTS .......................................................................................................................................... 42 I. EXPOSURE MODELING/MEDICAL SURVEILLANCE ................................................................................... 42 SECTION XVI - ENGINEERING CONTROLS ................................................................................................................................ 43 SECTION XVII - ADMINISTRATIVE CONTROLS .......................................................................................................................... 44 SECTION XVIII - PERSONAL PROTECTIVE EQUIPMENT .......................................................................................................... 46 A. GENERAL CONSIDERATIONS ...................................................................................................................... 46 B. PROTECTION AGAINST INHALATION HAZARDS ....................................................................................... 46 SECTION XIX - CHEMICAL STORAGE ......................................................................................................................................... 48 SECTION XX - WASTE DISPOSAL ............................................................................................................................................... 52 A. CHEMICAL WASTES ..................................................................................................................................... 52 B. INFECTIOUS OR BIOLOGICAL WASTES ..................................................................................................... 52 C. RADIOACTIVE WASTES ................................................................................................................................ 52 D. BROKEN GLASS AND EMPTY CONTAINERS.............................................................................................. 53 E. PHARMACETICAL WASTE ............................................................................................................................ 53 SECTION XXI - EMERGENCY RESPONSE .................................................................................................................................. 54 A. GENERAL ....................................................................................................................................................... 54 B. SPILL INFORMATION
Load more

Recommended publications
  • Sassafras Tea: Using a Traditional Method of Preparation to Reduce the Carcinogenic Compound Safrole Kate Cummings Clemson University, [email protected]
    Clemson University TigerPrints All Theses Theses 5-2012 Sassafras Tea: Using a Traditional Method of Preparation to Reduce the Carcinogenic Compound Safrole Kate Cummings Clemson University, [email protected] Follow this and additional works at: https://tigerprints.clemson.edu/all_theses Part of the Forest Sciences Commons Recommended Citation Cummings, Kate, "Sassafras Tea: Using a Traditional Method of Preparation to Reduce the Carcinogenic Compound Safrole" (2012). All Theses. 1345. https://tigerprints.clemson.edu/all_theses/1345 This Thesis is brought to you for free and open access by the Theses at TigerPrints. It has been accepted for inclusion in All Theses by an authorized administrator of TigerPrints. For more information, please contact [email protected]. SASSAFRAS TEA: USING A TRADITIONAL METHOD OF PREPARATION TO REDUCE THE CARCINOGENIC COMPOUND SAFROLE A Thesis Presented to the Graduate School of Clemson University In Partial Fulfillment of the Requirements for the Degree Master of Science Forest Resources by Kate Cummings May 2012 Accepted by: Patricia Layton, Ph.D., Committee Chair Karen C. Hall, Ph.D Feng Chen, Ph. D. Christina Wells, Ph. D. ABSTRACT The purpose of this research is to quantify the carcinogenic compound safrole in the traditional preparation method of making sassafras tea from the root of Sassafras albidum. The traditional method investigated was typical of preparation by members of the Eastern Band of Cherokee Indians and other Appalachian peoples. Sassafras is a tree common to the eastern coast of the United States, especially in the mountainous regions. Historically and continuing until today, roots of the tree are used to prepare fragrant teas and syrups.
    [Show full text]
  • Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances 2017
    INTERNATIONAL NARCOTICS CONTROL BOARD Precursors and chemicals frequently used in the illicit manufacture of narcotic drugs and psychotropic substances 2017 EMBARGO Observe release date: Not to be published or broadcast before Thursday, 1 March 2018, at 1100 hours (CET) UNITED NATIONS CAUTION Reports published by the International Narcotics Control Board in 2017 The Report of the International Narcotics Control Board for 2017 (E/INCB/2017/1) is supplemented by the following reports: Narcotic Drugs: Estimated World Requirements for 2018—Statistics for 2016 (E/INCB/2017/2) Psychotropic Substances: Statistics for 2016—Assessments of Annual Medical and Scientific Requirements for Substances in Schedules II, III and IV of the Convention on Psychotropic Substances of 1971 (E/INCB/2017/3) Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances: Report of the International Narcotics Control Board for 2017 on the Implementation of Article 12 of the United Nations Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances of 1988 (E/INCB/2017/4) The updated lists of substances under international control, comprising narcotic drugs, psychotropic substances and substances frequently used in the illicit manufacture of narcotic drugs and psychotropic substances, are contained in the latest editions of the annexes to the statistical forms (“Yellow List”, “Green List” and “Red List”), which are also issued by the Board. Contacting the International Narcotics Control Board The secretariat of the Board may be reached at the following address: Vienna International Centre Room E-1339 P.O. Box 500 1400 Vienna Austria In addition, the following may be used to contact the secretariat: Telephone: (+43-1) 26060 Fax: (+43-1) 26060-5867 or 26060-5868 Email: [email protected] The text of the present report is also available on the website of the Board (www.incb.org).
    [Show full text]
  • Methyleugenol (4-Allyl-1,2-Dimethoxybenzene)
    EUROPEAN COMMISSION HEALTH & CONSUMER PROTECTION DIRECTORATE-GENERAL Directorate C - Scientific Opinions C2 - Management of scientific committees II; scientific co-operation and networks Scientific Committee on Food SCF/CS/FLAV/FLAVOUR/4 ADD1 FINAL 26 September 2001 Opinion of the Scientific Committee on Food on Methyleugenol (4-Allyl-1,2-dimethoxybenzene) (adopted on 26 September 2001) Rue de la Loi 200, B-1049 Bruxelles/Wetstraat 200, B-1049 Brussel - Belgium - Office: F101 - 6/172 Telephone: direct line (+32-2) 295.4861, switchboard 299.11.11. Fax: (+32-2) 299.4891 Telex: COMEU B 21877. Telegraphic address: COMEUR Brussels http://europa.eu.int/comm/food/fs/sc/scf/index_en.html SCF/CS/FLAV/FLAVOUR/4 ADD1 FINAL Opinion of the Scientific Committee on Food on Methyleugenol (4-Allyl-1,2-dimethoxybenzene) (adopted on 26 September 2001) Terms of reference The Committee is asked to advise the Commission on substances used as flavouring substances or present in flavourings or present in other food ingredients with flavouring properties for which existing toxicological data indicate that restrictions of use or presence might be necessary to ensure safety for human health. In particular, the Committee is asked to advise the Commission on the implications for human health of methyleugenol (4-allyl-1,2-dimethoxybenzene) in the diet. Introduction In 1999 methyleugenol was evaluated by the Committee of Experts on Flavouring Substances of the Council of Europe. The conclusions of this Committee were: "Available data show that methyleugenol is a naturally-occurring genotoxic carcinogen compound with a DNA-binding potency similar to that of safrole. Human exposure to methyleugenol may occur through the consumption of foodstuffs flavoured with aromatic plants and/or their essential oil fractions which contain methyleugenol.
    [Show full text]
  • Safrole and the Versatility of a Natural Biophore Lima, L
    Artigo Safrole and the Versatility of a Natural Biophore Lima, L. M.* Rev. Virtual Quim., 2015, 7 (2), 495-538. Data de publicação na Web: 31 de dezembro de 2014 http://www.uff.br/rvq Safrol e a Versatilidade de um Biofóro Natural Resumo: Safrol (1) obtido de óleos essenciais de diferentes espécies vegetais tem ampla aplicação na indústria química como precursor sintético do butóxido de piperonila, piperonal e de fármacos como a tadalafila, cinoxacina e levodopa. Do ponto vista toxicológico, é considerado uma hepatotoxina por mecanismo de bioativação metabólica conduzindo a formação de intermediários eletrofílicos, e tem sido descrito como inibidor de diferentes isoenzimas da família CYP450. A versatilidade de sua estrutura, permitindo várias transformações químicas, e a natureza biofórica de sua unidade benzodioxola ou metilenodioxifenila conferem-lhe características singulares, que o tornam atrativo material de partida para a síntese de compostos com distintas atividades farmacológicas. Exemplos selecionados de compostos bioativos, naturais e sintéticos, contendo o sistema benzodioxola serão comentados, incluindo aqueles provenientes de contribuição específica do LASSBio®. Palavras-chave: Safrol; benzodioxola; metilenodioxi; CYP450; bióforo; compostos bioativos. Abstract Safrole (1), obtained from essential oils from different plant species, has wide application in the chemical industry as a synthetic precursor of piperonyl butoxide, piperonal and drugs such as tadalafil, cinoxacin and levodopa. From the toxicological point of view, it is considered a hepatotoxin through metabolic bioactivation, leading to the formation of electrophilic metabolites, and has been described as an inhibitor of different CYP450 isoenzymes. The versatility of its structure, allowing various chemical transformations, and the biophoric nature of its benzodioxole or methylenedioxy subunit, give it unique features and make it an attractive starting material for the synthesis of compounds with different pharmacological activities.
    [Show full text]
  • Extraction of Safrole from Essential Oils with Ionic Liquids
    João Miguel Pinheiro Pinto Burguete Cardoso Bachelor degree in Chemical and Biochemical Engineering Extraction of safrole from essential oils with ionic liquids Dissertation submitted in partial fulfillment of the requirements for the degree of Master of Science in Chemical and Biochemical Engineering Adviser: Ewa Bogel-Łukasik, Auxiliary Researcher, Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa Co-adviser: Urszula Domanska-´ Zelazna,˙ Department of Physical Chemistry, Faculty of Chemistry, Warsaw University of Technology Examination Committee Chairperson: Mário Fernando José Eusébio Members: Luís Alexandre Almeida Fernandes Cobra Branco Ewa Bogel-Łukasik March, 2017 Extraction of safrole from essential oils with ionic liquids Copyright © João Miguel Pinheiro Pinto Burguete Cardoso, Faculty of Sciences and Tech- nology, NOVA University of Lisbon. The Faculty of Sciences and Technology and the NOVA University of Lisbon have the right, perpetual and without geographical boundaries, to file and publish this disserta- tion through printed copies reproduced on paper or on digital form, or by any other means known or that may be invented, and to disseminate through scientific reposito- ries and admit its copying and distribution for non-commercial, educational or research purposes, as long as credit is given to the author and editor. This document was created using the (pdf)LATEX processor, based in the “unlthesis” template[1], developed at the Dep. Informática of FCT-NOVA [2]. [1] https://github.com/joaomlourenco/unlthesis [2] http://www.di.fct.unl.pt Acknowledgements I am grateful to FCT/UNL and the Physical Chemistry department at Warsaw University of Technology for providing me the opportunity to study abroad as well as their staff for its continuous collaboration on this research work.
    [Show full text]
  • Gas Chromatographic and Mass Spectrometric Analysis of N-Methyl-1-Aryl-2-Propanamines Synthesized from the Substituted Allylbenzenes Present in Sassafras Oil
    Journal of Chromatographic Science, Vol. 29, June 1991 Gas Chromatographic and Mass Spectrometric Analysis of N-Methyl-1-aryl-2-propanamines Synthesized from the Substituted Allylbenzenes Present in Sassafras Oil F.T. Noggle, Jr. Alabama Department of Forensic Sciences, Wire Road, Auburn, Alabama 36830 C. Randall Clark and Jack DeRuiter Department of Pharmacal Sciences, School of Pharmacy, Auburn University, Auburn, Alabama 36849 A variety of methods have been reported for the synthesis of I Abstract I MDA, MDMA, and related compounds (5,6). The most direct One method used for the synthesis of the illicit drug N-methyl- approach involves treatment of the commercially available 1-(3,4-methylenedioxyphenyl)-2-propanami ne (methylene- ketone 1-(3,4-methylenedioxyphenyl)-2-propanone (3,4- dioxymethamphetamine, MDMA) involves the treatment of methylenedioxyphenylacetone) with ammonia or methylamine safrole with HBr to form the intermediate 2-bromosafrole, under reducing conditions as shown in Scheme 1. Based on this followed by bromide displacement with methylamine. The synthetic strategy, the availability of the ketone was controlled by starting material required for this synthesis, safrole, may be the Drug Enforcement Administration under the Chemical Di- obtained from sassafras oil which is isolated from the roots of version and Trafficking Act in March of 1989. The restricted the sassafras plant. In addition to safrole, sassafras oil availability of the key ketone precursor has forced clandestine contains other allyl benzenes such as eugenol and 4-allyl-1 ,2- laboratory operators to seek alternative approaches for the syn- dimethoxybenzene. Gas chromatography-mass spectrometric thesis of MDA and MDMA. One such alternate method em- (GC-MS) studies show that these allyl benzenes may also be ploys the natural product safrole, which is commercially avail- brominated and undergo amine displacement to yield the able or can be obtained by extraction or distillation of the corresponding N-methyl-1-aryl-2-propanamines.
    [Show full text]
  • Myristica Fragrans Houtt.) That Inhibit Locomotor Activity in Mice
    Int. J. Mol. Sci. 2010, 11, 4771-4781; doi:10.3390/ijms11114771 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 www.mdpi.com/journal/ijms Article Identification of Compounds in the Essential Oil of Nutmeg Seeds (Myristica fragrans Houtt.) That Inhibit Locomotor Activity in Mice Muchtaridi 1,*, Anas Subarnas 1, Anton Apriyantono 2 and Resmi Mustarichie 1 1 Faculty of Pharmacy, Universitas Padjadjaran, Jl KM 21.5 Bandung-Sumedang, Jatinangor, Indonesia; E-Mails: [email protected] (A.S.); [email protected] (R.M.) 2 Department of Food Technology and Human Nutrition, Bogor Agricultural University, Jl. Darmaga, Bogor, Indonesia; E-Mail: [email protected] * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +62-22-7796200; Fax: +62-22-7796200. Received: 11 October 2010; in revised form: 8 November 2010 / Accepted: 15 November 2010 / Published: 23 November 2010 Abstract: The present study was designed to evaluate the inhibitory effect of nutmeg (Myristica fragrans Houtt.) seed essential oil on the locomotor activity of mice in a wheel cage. Active compounds in the essential oil were identified by off-line solid phase extraction (SPE-C18) and GC/MS analysis. The essential oil was administered by inhalation at doses of 0.1, 0.3, and 0.5 mL/cage. The results showed that inhalation of nutmeg seed essential oil at a dose of 0.5 mL/cage decreased locomotion by 68.62%; and inhalation of 0.1 and 0.3 mL/cage inhibited locomotion by 62.81% and 65.33%, respectively. Generally, larger doses and longer administrations of nutmeg seed essential oil exhibited greater locomotor inhibition.
    [Show full text]
  • Chemicals Required for the Illicit Manufacture of Drugs Table 1 SUBSTANCES in TABLES I and II of the 1988 CONVENTION
    Chemicals Required 1. A variety of chemicals are used in the illicit manufacture of for the Illicit drugs. The United Nations Convention against Illicit Traffic in Manufacture of Drugs Narcotic Drugs and Psychotropic Substances of 1988 (1988 Convention) refers to “substances frequently used in the illicit manufacture of narcotic drugs and psychotropic substances”. Twenty-two such substances are listed in Tables I and II of the 1988 Convention as in force on 1st May, 1998. (See Table1) Table 1 Table I Table II SUBSTANCES IN N-Acetylanthranilic acid. Acetic anhydride TABLES I AND II OF Ephedrine Acetone THE 1988 Ergometrine Anthranilic acid CONVENTION Ergotamine Ethyl ether Isosafrole Hydrochloric acid* Lysergic acid Methyl ethyl ketone 3,4-methylenedioxyphenyl-2-propanone Phenylacetic acid 1-phenyl-2-propanone Piperidine Piperonal Potassium permanganate Pseudoephedrine Sulphuric acid* Safrole Toluene The salts of the substances in this Table The salts of the substances whenever the existence of such salts is in this Table whenever the possible. existence of such salts is possible. * The salts of hydrochloric acid and sulphuric acid are specifically excluded from Table II. U N D C P 11 The term “precursor” is used to indicate any of these substances in the two Tables. Chemicals used in the illicit manufacture of narcotic drugs and psychotropic substances are often described as precursors or essential chemicals, and these include true precursors, solvents, oxidising agents and other Chemicals used in the illicit manufacture of narcotic substances. Although the term is not drugs and psychotropic substances are often technically correct, it has become common described as precursors or essential chemicals, and practice to refer to all such substances as these include true precursors, solvents, oxidising “precursors”.
    [Show full text]
  • Biomolecules of Interest Present in the Main Industrial Wood Species Used in Indonesia-A Review
    Tech Science Press DOI: 10.32604/jrm.2021.014286 REVIEW Biomolecules of Interest Present in the Main Industrial Wood Species Used in Indonesia-A Review Resa Martha1,2, Mahdi Mubarok1,2, Wayan Darmawan2, Wasrin Syafii2, Stéphane Dumarcay1, Christine Gérardin Charbonnier1 and Philippe Gérardin1,* 1Université de Lorraine, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement, Laboratoire d'Etudes et de Recherche sur le Matériau Bois, Nancy, France 2Department of Forest Products, Faculty of Forestry and Environment, Institut Pertanian Bogor, Bogor University, Bogor, Indonesia *Corresponding Author: Philippe Gérardin. Email: [email protected] Received: 17 September 2020 Accepted: 20 October 2020 ABSTRACT As a tropical archipelagic country, Indonesia’s forests possess high biodiversity, including its wide variety of wood species. Valorisation of biomolecules released from woody plant extracts has been gaining attractive interests since in the middle of 20th century. This paper focuses on a literature review of the potential valorisation of biomole- cules released from twenty wood species exploited in Indonesia. It has revealed that depending on the natural origin of the wood species studied and harmonized with the ethnobotanical and ethnomedicinal knowledge, the extractives derived from the woody plants have given valuable heritages in the fields of medicines and phar- macology. The families of the bioactive compounds found in the extracts mainly consisted of flavonoids, stilbenes, stilbenoids, lignans, tannins, simple phenols, terpenes, terpenoids, alkaloids, quinones, and saponins. In addition, biological or pharmacological activities of the extracts/isolated phytochemicals were recorded to have antioxidant, antimicrobial, antifungal, anti-inflammatory, anti-diabetes, anti-dysentery, anticancer, analgesic, anti-malaria, and anti-Alzheimer activities.
    [Show full text]
  • The Relative Content and Distribution of Absorbed Volatile Organic
    molecules Article The Relative Content and Distribution of Absorbed Volatile Organic Compounds in Rats Administered Asari Radix et Rhizoma Are Different between Powder- and Decoction-Treated Groups Guang-Xue Liu 1, Feng Xu 1, Ming-Ying Shang 1,*, Xuan Wang 2 and Shao-Qing Cai 1,* 1 Division of Pharmacognosy, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China; [email protected] (G.-X.L.); [email protected] (F.X.) 2 Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China; [email protected] * Correspondence: [email protected] (M.-Y.S.); [email protected] (S.-Q.C.); Tel.: +86-10-8280-2534 (M.-Y.S.); +86-10-8280-1693 (S.-Q.C.) Received: 20 August 2020; Accepted: 25 September 2020; Published: 27 September 2020 Abstract: Asari Radix et Rhizoma (ARR) is an important traditional Chinese medicine. Volatile organic compounds (VOCs) are the main active constituents of ARR. Research on the metabolite profile of VOCs and the difference of absorbed constituents in vivo after an administration of ARR decoction and powder will be helpful to understand the pharmacological activity and safety of ARR. In this study, headspace solid-phase microextraction gas chromatography mass spectrometry (HS–SPME–GC–MS) was applied to profile the VOCs from ARR in rats in vivo. A total of 153 VOCs were tentatively identified; 101 were original constituents of ARR (98 in the powder-treated group and 43 in the decoction-treated group) and 15 were metabolites, and their metabolic reactions were mainly oxidation and reduction, with only two cases of methylation and esterification, and 37 unclassified compounds were identified only in the ARR-treated group.
    [Show full text]
  • Safrole Safety Data Sheet According to Federal Register / Vol
    Safrole Safety Data Sheet according to Federal Register / Vol. 77, No. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 06/13/2015 Version: 1.0 SECTION 1: Identification 1.1. Identification Product form : Substance Substance name : Safrole CAS-No. : 94-59-7 Product code : (US) W1747 Formula : C10H10O2 Synonyms : 4-Allyl-1,2-(methylenedioxy)-benzene / 4-Allyl-1,2-methylenedioxybenzene / 1-Allyl-3,4- methylenedioxybenzene / Allylcatechol methylene ether / Allyldioxybenzene methylene ether / m- Allylpyrocatechin methylene ether / 4-Allylpyrocatechol formaldehyde acetal / Allylpyrocatechol methylene ether / Benzene, 1,2-methylenedioxy-4-allyl- / Benzene, 4-allyl-1,2-(methylenedioxy)- / Benzo-1,3-dioxole, 5-(2-propenyl)- / 1,3-Benzodioxole, 5-(2-propenyl)- / 1,3-Benzodioxole, 5-allyl- / 1,2-Methylenedioxy-4-allylbenzene / 5-(2-Propenyl)-1,3-benzodioxole / Rhyuno oil / 5-Allyl-1,3- benzodioxole / Safrol / 1,3-Benzodioxole, 5-(2-propen-1-yl)- 1.2. Recommended use and restrictions on use No additional information available 1.3. S upplie r Synerzine 5340 Hwy 42 S Ellenwood, Georgia 30294 - USA T 404-524-6744 - F 404-577-1651 [email protected] - www.synerzine.com 1.4. Emergency telephone number Emergency number : Infotrac 1-800-535-5053 (Contract# 102471) Dial +1-352-323-3500 when outside the US SECTION 2: Hazard(s) identification 2.1. Classification of the substance or mi xt ure GHS -US classification Acute toxicity (oral) H302 Harmful if swallowed Category 4 Germ cell mutagenicity H341 Suspected of causing genetic defects (Not classified) Category 2 Carcinogenicity Category 1B H350 May cause cancer (Not classified) Skin corrosion/irritation H315 Causes skin irritation Category 2 Full text of H statements : see section 16 2.2.
    [Show full text]
  • Pharmacokinetic Study of Safrole and Methyl Eugenol After Oral Administration of the Essential Oil Extracts of Asarum in Rats by GC-MS
    Hindawi BioMed Research International Volume 2021, Article ID 6699033, 8 pages https://doi.org/10.1155/2021/6699033 Research Article Pharmacokinetic Study of Safrole and Methyl Eugenol after Oral Administration of the Essential Oil Extracts of Asarum in Rats by GC-MS Yuqi Fan ,1,2 Dongyue Yang,2 Xuhua Huang,2 Guangzhe Yao,2 Wei Wang,2 Mengyuan Gao,2 Xiaohua Jia,2 Huizi Ouyang ,1,2 Yanxu Chang,2 and Jun He 2 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, 300193 Tianjin, China 2State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China Correspondence should be addressed to Huizi Ouyang; [email protected] and Jun He; [email protected] Received 27 October 2020; Revised 17 January 2021; Accepted 11 March 2021; Published 20 March 2021 Academic Editor: Sun Jin Hur Copyright © 2021 Yuqi Fan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Asarum is a traditional medicine and has been widely used as remedies for inflammatory diseases, toothache, headache, local anesthesia, and aphthous stomatitis in China, Japan, and Korea. Our previous research found that safrole and methyl eugenol were vital compounds that contribute to distinguish the different species and raw Asarum and its processed products apart. The pharmacokinetics of safrole and methyl eugenol after oral administration of Asarum extract has not been reported yet. In this study, a rapid and simple gas chromatography–mass spectroscopy (GC–MS) method that has a complete run time of only 4.5 min was developed and validated for the simultaneous determination and pharmacokinetic study of safrole and methyl eugenol in rat plasma after administration of Asarum extracts.
    [Show full text]