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Cold Spring Harbor Symposia on Quantitative Biology COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME LVII COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME LVII The Cell Surface COLD SPRING HARBOR LABORATORY PRESS 1992 COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY VOLUME LVII 1992 by The Cold Spring Harbor Laboratory Press International Standard Book Number 0-87969-063-1 (cloth) International Standard Book Number 0-87969-064-X (paper) International Standard Serial Number 0091-7451 Library of Congress Catalog Card Number 34-8174 Printed in the United States of America All rights reserved COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY Founded in 1933 by REGINALD G. HARRIS Director of the Biological Laboratory 1924 to 1936 Previous Symposia Volumes I (1933) Surface Phenomena xxvII (1962) Basic Mechanisms in Animal Virus Biology II (1934) Aspects of Growth XXVIII (1963) Synthesis and Structure of Macromolecules III (1935) Photochemical Reactions XXIX (1964) Human Genetics IV (1936) Excitation Phenomena XXX (1965) Sensory Receptors V (1937) Internal Secretions XXXI (1966) The Genetic Code VI (1938) Protein Chemistry XXXII (1967) Antibodies VII (1939) Biological Oxidations XXXIII (1968) Replication of DNA in Microorganisms VIII (1940) Permeability and the Nature of Cell Membranes XXXIV (1969) The Mechanism of Protein Synthesis IX (1941) Genes and Chromosomes: Structure and Organi- XXXV (1970) Transcription of Genetic Material zation XXXVI (1971) Structure and Function of Proteins at the X (1942) The Relation of Hormones to Development Three-dimensional Level XI (1946) Heredity and Variation in Microorganisms XXXVII (1972) The Mechanism of Muscle Contraction XII (1947) Nucleic Acids and Nucleoproteins XXXVIII (1973) Chromosome Structure and Function XIII (1948) Biological Applications of Tracer Elements XXXIX (1974) Tumor Viruses XIV (1949) Amino Acids and Proteins XL (1975) The Synapse XV (1950) Origin and Evolution of Man XLI (1976) Origins of Lymphocyte Diversity XVI (1951) Genes and Mutations XLII (1977) Chromatin XVII (1952) The Neuron XLIII (1978) DNA: Replication and Recombination XVIII (1953) Viruses XLIV (1979) Viral Oncogenes XIX (1954) The Mammalian Fetus: Physiological Aspects of XLV (1980) Movable Genetic Elements Development XLVI (1981) Organization of the Cytoplasm XX (1955) Population Genetics: The Nature and Causes of XLVII (1982) Structures of DNA Genetic Variability in Population XLVIII (1983) Molecular Neurobiology XXI (1956) Genetic Mechanisms: Structure and Function XLIX (1984) Recombination at the DNA Level XXII (1957) Population Studies: Animal Ecology and De- L (1985) Molecular Biology of Development mography LI (1986) Molecular Biology of Homo sapiens XXIII (1958) Exchange of Genetic Material: Mechanism and LII (1987) Evolution of Catalytic Function Consequences LIII (1988) Molecular Biology of Signal Transduction XXIV (1959) Genetics and Twentieth Century Darwinism LIV (1989) Immunological Recognition XXV (1960) Biological Clocks LV (1990) The Brain XXVI (1961) Cellular Regulatory Mechanisms LVI (1991) The Cell Cycle Front Cover (Paperback): Ablation of neurons at the optic chiasm prevents growth of axons of retinal ganglion cells into the optic chiasm. (For details, see Reichardt et al., p. 426, this volume.) Back Cover (Paperback): Agrin-transfected cells induce clustering of AChRs. (For details, see Campanelli et al., p. 467, this volume.) Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Cold Spring Harbor Laboratory for libraries and other users registered with the Copyright Clearance Center (CCC) Transactional Reporting Service, provided that the base fee of $3.00 per article is paid directly to CCC, 21 Congress St., Salem MA 01970. [0-87969-063-1/92 $3.00 + .00]. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. All Cold Spring Harbor Laboratory Press publications may be ordered directly from Cold Spring Harbor Laboratory Press, 10 Skyline Drive, Plainview, New York 11803. Phone: 1-800-843-4388 (Continental U.S. and Canada); (516)349-1930 (All other locations). FAX: (516)349-1946. Symposium Participants ADIE, ELAINE, Dept. of Biochemistry, University Molecular Medicine, Howard Hughes Medi- of Glasgow, Scotland cal Institute, University of California, San AGER, ANN, Dept. of Celt and Structural Biolo- Diego gy, University of Manchester, United BmNBAUMER, LUTZ, Dept. of Cell Biology, Kingdom Baylor College of Medicine, Houston, AKESON, RICHARD, Dept. of Basic Science Re- Texas search, Children's Hospital Research Foun- BIRNBAUMER, MARIEL, Dept. of Cell Biology, dation, Cincinnati, Ohio Baylor College of Medicine, Houston, ALTSCHULER, DANIEL, Dept. of Cell Biology, Texas Burroughs Wellcome Co., Research Tri- BLOBEL, GUNTER, Howard Hughes Medical Insti- angle Park, North Carolina tute, Rockefeller University, New York, AMANN, EGON, Pharma Research Laboratories, New York Hoechst Japan, Ltd., Kawagoe-Saitama, BLOOM, THEODORA, Nature, London, United Japan Kingdom ANDERSON, KATHRYN, Dept. of Molecular and BONHOEFFER, FRIEDRICH,Abteilung Physikalische Cell Biology, University of California, Ber- Biologie, Max Planck Institute, Tubingen, keley Germany ANDERSON, RICHARD, Dept. of Cell Biology and BOOTH, PAUL, Dept. of Cellular Biochemistry, Neuroscience, University of Texas South- Life Technologies Inc., Gaithersburg, western Medical Center, Dallas Maryland APPLEBURY, MEREDITH, Eye Research Laborator- BORST, JANNIE, Dept. of Immunology, Nether- ies, University of Chicago, Illinois lands Cancer Institute, Amsterdam, The ARTAVANIS-TsAKONAS, SPYRIDON, Dept. of Molec- Netherlands ular and Developmental Neurobiology, BossY, BLAISE, Howard Hughes Medical Insti- Boyer Center for Molecular Medicine, Yale tute, University of California, San Francisco University, New Haven, Connecticut BOURNE, HENRY, Department of Pharmacology, ASHKENAZI, AVI, Dept. of Molecular Biology, University of California, San Francisco Genentech, Inc., South San Francisco, Cali- BRANDLEY, BRIAN, Glycomed Inc., Alameda, fornia California ATTISANO, LILLIAN, Dept. of Cell Biology, Me- BRONSON, RICHARD, Dept. of Obstetrics and morial Sloan-Kettering Cancer Center, New Gynecology, State University of New York, York, New York Stony Brook AXLE, RICHARD, Howard Hughes Medical Insti- BROWN, ABRAHAM, Lederle Laboratory, Pearl tute, Columbia University, New York, New River, New York York BROWN, MICHAEL, Center for Genetic Disease, BAUER, MARGARET, Dept. of Medical Microbiol- University of Texas Southwestern Medical ogy and Immunology, University of Wiscon- Center, Dallas sin, Madison BROWNING, JEFFREY, Dept. of Cell Biology, BEKKERS, AUGUST, Dept. of Enzymology and Biogen, Cambridge, Massachusetts Protein Engineering, Institute of Biomem- BRUGGE, JOAN, Dept. of Microbiology, Universi- branes, Utrecht, The Netherlands ty of Pennsylvania School of Medicine, Phil- BELL, GREGORY, Dept. of Medicine, University adelphia of California, San Francisco BURLtNGAME, A.L., Dept. of Pharmaceutical BERSTEIN, GABRIEL, Dept. of Pharmacology, Chemistry, University of California, San University of Texas Southwestern Medical Francisco Center, Dallas BURNETT, J. PAUL, Dept. of Molecular and Cell BEVlLACQUA, MICHAEL, Dept. of Cellular and Biology Research, Lilly Research Labora- vi SYMPOSIUM PARTICIPANTS tories, Lilly Corporate Center, Indianapolis, Molecular Pathology, Merck Research Lab- Indiana oratories, Rahway, New Jersey BURRIDGE, KEITH, Dept. of Cell Biology and DEVREOTES, PETER, Dept. of Biological Chemis- Anatomy, University of North Carolina, try, Johns Hopkins Medical School, Balti- Chapel Hill more, Maryland BYTH, KATE, Dept. of Immunology and Pathol- DICKESON, KENT, Dept. of Biotechnology and ogy, Cambridge University, United Microbiology, Wyeth-Ayerst Research, Kingdom Radnor, Pennsylvania CAMPBELL, BOB, Ares Advanced Technology, DILIBERTO, EMANUEL, Dept. of Medical Bio- Randolph, Massachusetts chemistry, Burroughs Wellcome Co., Re- CARAS, INGRID, Dept. of Immunobiology, search Triangle Park, North Carolina Genentech, Inc., South San Francisco, Cali- DILORENZO, TERESA, Dept. of Otolaryngology, fornia Long Island Jewish Medical Center, New CARMELIET, PETER, Whitehead Institute, Cam- Hyde Park, New York bridge, Massachusetts DRICKAMER, KURT, Dept. of Biochemistry and CARPEN, OLLI, Dept. of Pathology, University of Molecular Biophysics, Columbia University, Helsinki, Finland New York, New York CATTERALL, CATHERINE, Dept. of Inflammation DUDLEY, DAVID, Signal Transduction, Parke- Biology, CellTech Ltd., Slough, Berkshire, Davis Pharmaceutical Corp., Ann Arbor, United Kingdom Michigan CHAN, Po-YING, Dept. of Cellular Interactions, EDELMAN, GERALD, Dept. of Developmental and Bristol-Myers Squibb PRI, Seattle, Molecular Biology, Rockefeller University, Washington New York, New York CHANG, CHIA-PING, School of Medicine, Uni- EINSTEIN, RICHARD, Dept. of Molecular Ge- versity of California at San Diego, La Jolla netics, SmithKline Beecham, King of Prus- CHANG, XIO-JIA, Dept. of Cell Adhesion Pro- sia, Pennsylvania teins, Genetics Institute, Cambridge, Massa- ENDEMANN, GERDA, Scios, Inc., Mountain View, chusetts California CHARDIN, PIERRE, CNRS-Institut de Pharmacol- FARRELL, FRANCIS, Dept. of Cell Biology, Bur- ogie, Valbonne, France roughs Wellcome Co., Research Triangle CHEN, MANN-JY, Dept. of Microbiology and Im- Park, North Carolina munology, Jefferson Cancer Institute,
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