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Rabbit Anti-RASA4/FITC Conjugated antibody

SL19732R-FITC

Product Name: Anti-RASA4/FITC Chinese Name: FITC标记的GTP酶激活蛋白样RASA4抗体 Ca2+ promoted Ras inactivator; Calcium promoted Ras inactivator; CAPRI; GAPL; RASL2_HUMAN; GTPase activating protein like; KIAA0538; MGC131890; Ras Alias: GTPase activating protein 4; RAS p21 protein activator 4; RasGAP activating like protein 2. Organism Species: Rabbit Clonality: Polyclonal React Species: Human,Mouse, ICC=1:50-200IF=1:50-200 Applications: not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Molecular weight: 90kDa Form: Lyophilized or Liquid Concentration: 1mg/ml immunogen: KLH conjugated synthetic peptide derived from human RASA4 Lsotype: IgG Purification: affinitywww.sunlongbiotech.com purified by Protein A Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year Storage: when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. background: This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Product Detail: Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function: Ca2+-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis.

Subcellular Location: Cytoplasm; cytosol. Cell membrane; peripheral membrane protein. Note=Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist- stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with the plasma membrane.

Tissue Specificity: Widely expressed.

Similarity: Contains 1 Ras-GAP domain.

Database links:

Entrez Gene: 10156 Human

Entrez Gene: 54153 Mouse

Entrez Gene: 288589 Rat

Omim: 607943 Human

SwissProt: O43374 Human

SwissProt: Q6PFQ7 Mouse

Unigene:www.sunlongbiotech.com 696339 Human

Unigene: 290655 Mouse

Unigene: 1366 Rat

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.