April 2, 2019 u vol. 116 u no. 14

From the Cover

6908 Rapid adaptation and transposable elements 6707 Sociopolitical history of southern Appalachia 6720 Cultural tightness in China 7027 Evolution of pathogen sensing 7113 Synaptic plasticity and learning

Contents

THIS WEEK IN PNAS Cover image: Pictured is an 6507 In This Issue inflorescence of Capsella rubella. Xiao-Min Niu et al. found that frequent insertions of transposable elements (TEs) INNER WORKINGS—An over-the-shoulder look at scientists at work in the genome of C. rubella at the gene 6510 Ramping up the fight against Florida’s red tides FLOWERING LOCUS C (FLC) can Sid Perkins regulate flowering time. Moreover, TE insertion at the 30 untranslated region of FLC reduces mRNA stability to promote — flowering. The findings suggest that TEs CORE CONCEPTS A brief introduction to emerging topics in science may support rapid adaptation to 6513 Holey synthetic materials open their pores to medical applications changing environments. See the article Nina Notman by Niu et al. on pages 6908–6913. Image courtesy of Jie Zhang (Chinese Academy of Sciences, Beijing). QNAS 6517 QnAs with C. Y. Cyrus Chu Sandeep Ravindran See Inaugural Article on page 6548

COMMENTARIES 6519 Social networks and the archaeology of the Native American South Christopher B. Rodning See companion article on page 6707 6522 Universal and culture-specific patterns of tightness-looseness across the 31 Chinese provinces Michele J. Gelfand See companion article on page 6720 6525 Pseudomonas aeruginosa in cystic fibrosis: A chronic cheater Christopher M. Waters and Joanna B. Goldberg See companion articles on pages 7021 and 7027 6528 Retinoic acid receptor plays both sides of homeostatic plasticity Brandon J. Walters and Sheena A. Josselyn See companion article on page 7113

Free online through the PNAS open access option. PNAS u April 2, 2019 u vol. 116 u no. 14 u iii–ix Downloaded by guest on October 1, 2021 BIOPHYSICS AND COMPUTATIONAL BIOLOGY PERSPECTIVE 6594 Heterogeneous and rate-dependent streptavidin– 6531 Toward understanding the impact of artificial biotin unbinding revealed by high-speed force intelligence on labor spectroscopy and atomistic simulations Morgan R. Frank, David Autor, James E. Bessen, Erik Felix Rico, Andreas Russek, Laura Gonza´lez, Helmut Brynjolfsson, Manuel Cebrian, David J. Deming, Maryann Grubmu¨ller, and Simon Scheuring Feldman, Matthew Groh, Jose´ Lobo, Esteban Moro, Dashun Wang, Hyejin Youn, and Iyad Rahwan 6602 Amyloid found in human cataracts with two- dimensional infrared spectroscopy Ariel M. Alperstein, Joshua S. Ostrander, Tianqi O. Zhang, LETTERS and Martin T. Zanni 6540 Ergodicity is sufficient but not necessary for 6766 Structural and mechanistic insights into group-to-individual generalizability mechanoactivation of focal adhesion kinase Janne K. Adolf and Eiko I. Fried Magnus Sebastian Bauer, Fabian Baumann, Csaba 6542 Reply to Adolf and Fried: Conditional equivalence Daday, Pilar Redondo, Ellis Durner, Markus Andreas Jobst, and imperatives for person-level science Lukas Frederik Milles, Davide Mercadante, Diana Angela Pippig, Hermann Eduard Gaub, Frauke Grater, John D. Medaglia, Bertus F. Jeronimus, and Aaron J. Fisher ¨ and Daniel Lietha 6544 A squared standard error is not a measure of 6775 Structural and dynamical rationale for fatty acid individual differences unsaturation in Escherichia coli Ellen L. Hamaker and Oisı´n Ryan Greg J. Dodge, Ashay Patel, Kara L. Jaremko, J. Andrew 6546 Reply to Hamaker and Ryan: Within-sample temporal McCammon, Janet L. Smith, and Michael D. Burkart instability in cross-sectional estimates 7071 Structural maturation of cortical perineuronal nets Aaron J. Fisher, Bertus F. Jeronimus, and John D. Medaglia and their perforating synapses revealed by superresolution imaging INAUGURAL ARTICLE Yaron M. Sigal, Haneui Bae, Luke J. Bogart, Takao K. Hensch, and Xiaowei Zhuang 6548 Variations of wealth resemblance by family relationship types in modern Chinese families C. Y. Cyrus Chu, Kamhon Kan, and Jou Chun Lin CHEMISTRY See QnAs on page 6517 6608 Volumetric chemical imaging by clearing-enhanced stimulated Raman scattering microscopy PHYSICAL SCIENCES Mian Wei, Lingyan Shi, Yihui Shen, Zhilun Zhao, Asja Guzman, Laura J. Kaufman, Lu Wei, and Wei Min APPLIED MATHEMATICS 6618 Host−guest complexation-mediated codelivery 6554 Generalized network dismantling of anticancer drug and photosensitizer for Xiao-Long Ren, Niels Gleinig, Dirk Helbing, and Nino Antulov-Fantulin cancer photochemotherapy Guocan Yu, Benyue Zhu, Li Shao, Jiong Zhou, Manik Lal Saha, Bingbing Shi, Zibin Zhang, Tao Hong, Shijun Li, Xiaoyuan Chen, APPLIED PHYSICAL SCIENCES and Peter J. Stang 6560 A minimal-length approach unifies rigidity in 6624 Solar-driven, highly sustained splitting of seawater underconstrained materials into hydrogen and oxygen fuels Matthias Merkel, Karsten Baumgarten, Brian P. Tighe, Yun Kuang, Michael J. Kenney, Yongtao Meng, and M. Lisa Manning Wei-Hsuan Hung, Yijin Liu, Jianan Erick Huang, 6569 Communities and regularities in the behavior of Rohit Prasanna, Pengsong Li, Yaping Li, Lei Wang, investment fund managers Meng-Chang Lin, Michael D. McGehee, Xiaoming Sun, Andrea Flori, Fabio Pammolli, Sergey V. Buldyrev, Luca Regis, and Hongjie Dai and H. Eugene Stanley 6630 Tracking the rotation of single CdS nanorods during 6575 Graphene transistor based on tunable Dirac photocatalysis with surface plasmon fermion optics resonance microscopy Ke Wang, Mirza M. Elahi, Lei Wang, K. M. Masum Habib, Yingyan Jiang, Hua Su, Wei Wei, Yongjie Wang, Hong-Yuan Takashi Taniguchi, Kenji Watanabe, James Hone, Avik W. Chen, and Wei Wang Ghosh, Gil-Ho Lee, and Philip Kim 6635 Interfacial engineering of cobalt sulfide/ 6580 Gold-implanted plasmonic quartz plate as a graphene hybrids for highly efficient launch pad for laser-driven photoacoustic ammonia electrosynthesis microfluidic pumps Pengzuo Chen, Nan Zhang, Sibo Wang, Tianpei Zhou, Shuai Yue, Feng Lin, Qiuhui Zhang, Njumbe Epie, Suchuan Yun Tong, Chengcheng Ao, Wensheng Yan, Lidong Dong, Xiaonan Shan, Dong Liu, Wei-Kan Chu, Zhiming Wang, Zhang, Wangsheng Chu, Changzheng Wu, and Jiming Bao and Yi Xie 6586 Electrical control of spatial resolution in mixed- 6784 Transcriptome-wide profiling of multiple RNA dimensional heterostructured photodetectors modifications simultaneously at single- Ke Zhang, Yang Wei, Jin Zhang, He Ma, Xinhe Yang, base resolution Gaotian Lu, Kenan Zhang, Qunqing Li, Kaili Jiang, Vahid Khoddami, Archana Yerra, Timothy L. Mosbruger, and Shoushan Fan Aaron M. Fleming, Cynthia J. Burrows, and Bradley R. Cairns

iv u www.pnas.org Contents Downloaded by guest on October 1, 2021 7015 Lysyl-tRNA synthetase as a drug target in malaria ENVIRONMENTAL SCIENCES and cryptosporidiosis 6673 Emergence of robust precipitation changes across Beatriz Baragan˜a, Barbara Forte, Ryan Choi, Stephen crop production areas in the 21st century Nakazawa Hewitt, Juan A. Bueren-Calabuig, Joa˜o Pedro Maisa Rojas, Fabrice Lambert, Julian Ramirez-Villegas, Pisco, Caroline Peet, David M. Dranow, David A. Robinson, and Andrew J. Challinor Chimed Jansen, Neil R. Norcross, Sumiti Vinayak, Mark Anderson, Carrie F. Brooks, Caitlin A. Cooper, Sebastian 6679 Tree clusters in savannas result from islands of Damerow, Michael Delves, Karen Dowers, James Duffy, soil moisture Thomas E. Edwards, Irene Hallyburton, Benjamin G. Horst, Ignacio Rodriguez-Iturbe, Zijuan Chen, Ann Carla Stave, Matthew A. Hulverson, Liam Ferguson, Marı´a Bele´n and Simon Asher Levin Jime´nez-Dı´az, Rajiv S. Jumani, Donald D. Lorimer, Melissa S. Love, Steven Maher, Holly Matthews, Case W. McNamara, Peter Miller, Sandra O’Neill, Kayode K. Ojo, Maria PHYSICS Osuna-Cabello, Erika Pinto, John Post, Jennifer Riley, Matthias 6684 Entanglement distribution over a 96-km-long Rottmann, Laura M. Sanz, Paul Scullion, Arvind Sharma, submarine optical fiber Sharon M. Shepherd, Yoko Shishikura, Frederick R. C. So¨ren Wengerowsky, Siddarth Koduru Joshi, Fabian Simeons, Erin E. Stebbins, Laste Stojanovski, Ursula Straschil, Steinlechner, Julien R. Zichi, Sergiy M. Dobrovolskiy, Rene´ Fabio K. Tamaki, Jevgenia Tamjar, Leah S. Torrie, Ame´lie van der Molen, Johannes W. N. Los, Val Zwiller, Vantaux, Benoıˆt Witkowski, Sergio Wittlin, Manickam Yogavel, Marijn A. M. Versteegh, Alberto Mura, Davide Calonico, Fabio Zuccotto, In˜igo Angulo-Barturen, Robert Sinden, Jake Massimo Inguscio, Hannes Hu¨bel, Liu Bo, Thomas Baum, Francisco-Javier Gamo, Pascal Ma¨ser, Dennis E. Kyle, Scheidl, Anton Zeilinger, Andre´ Xuereb, Elizabeth A. Winzeler, Peter J. Myler, Paul G. Wyatt, David and Rupert Ursin Floyd, David Matthews, Amit Sharma, Boris Striepen, Christopher D. Huston, David W. Gray, Alan H. Fairlamb, 6689 Fast scrambling on sparse graphs Andrei V. Pisliakov, Chris Walpole, Kevin D. Read, Wesley C. Gregory Bentsen, Yingfei Gu, and Andrew Lucas Van Voorhis, and Ian H. Gilbert 6695 Magnetoelastic hybrid excitations in CeAuAl  3 Petr Cerma´k, Astrid Schneidewind, Benqiong Liu, Michael EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES Marek Koza, Christian Franz, Rudolf Scho¨nmann, Oleg 6641 Anthropogenic enhancements to production of Sobolev, and Christian Pfleiderer highly oxygenated molecules from autoxidation Havala O. T. Pye, Emma L. D’Ambro, Ben H. Lee, Siegfried Schobesberger, Masayuki Takeuchi, Yue Zhao, Felipe STATISTICS Lopez-Hilfiker, Jiumeng Liu, John E. Shilling, Jia Xing, Rohit 6701 Detecting different topologies immanent in Mathur, Ann M. Middlebrook, Jin Liao, Andre´Welti,Martin scale-free networks with the same Graus, Carsten Warneke, Joost A. de Gouw, John S. Holloway, degree distribution Thomas B. Ryerson, Ilana B. Pollack, and Joel A. Thornton Dimitrios Tsiotas (Δημητριoς Tσιωτας) 6647 Limited oxygen production in the Mesoarchean ocean Frantz Ossa Ossa, Axel Hofmann, Jorge E. Spangenberg, SOCIAL SCIENCES Simon W. Poulton, Eva E. Stu¨eken, Ronny Schoenberg, Benjamin Eickmann, Martin Wille, Mike Butler, ANTHROPOLOGY and Andrey Bekker 6707 The social networks and structural variation of 6653 Intramolecular isotopic evidence for bacterial Mississippian sociopolitics in the southeastern oxidation of propane in subsurface natural United States gas reservoirs Jacob Lulewicz Alexis Gilbert, Barbara Sherwood Lollar, Florin Musat, See Commentary on page 6519 Thomas Giunta, Songcan Chen, Yuki Kajimoto, Keita Yamada, Christopher J. Boreham, Naohiro Yoshida, and Yuichiro Ueno ECONOMIC SCIENCES

ENGINEERING 6713 Measuring the impact of interaction between children of a matrilineal and a patriarchal culture 6659 Singlet oxygen mediated iron-based Fenton-like on gender differences in risk aversion catalysis under nanoconfinement Elaine M. Liu and Sharon Xuejing Zuo Zhichao Yang, Jieshu Qian, Anqing Yu, and Bingcai Pan 6749 Evidence that prenatal testosterone transfer from 6665 Lightweight, flaw-tolerant, and ultrastrong male twins reduces the fertility and socioeconomic nanoarchitected carbon success of their female co-twins Xuan Zhang, Andrey Vyatskikh, Huajian Gao, Julia R. Greer, Aline Bu¨tikofer, David N. Figlio, Krzysztof Karbownik, and Xiaoyan Li Christopher W. Kuzawa, and Kjell G. Salvanes 6790 Strong triaxial coupling and anomalous Poisson effect in collagen networks PSYCHOLOGICAL AND COGNITIVE SCIENCES Ehsan Ban, Hailong Wang, J. Matthew Franklin, Jan T. Liphardt, 6720 Mapping cultural tightness and its links to innovation, Paul A. Janmey, and Vivek B. Shenoy urbanization, and happiness across 31 provinces 6954 Biomaterials-aided mandibular reconstruction using in China in vivo bioreactors Roy Y. J. Chua, Kenneth G. Huang, and Mengzi Jin Alexander M. Tatara, Gerry L. Koons, Emma Watson, See Commentary on page 6522 Trenton C. Piepergerdes, Sarita R. Shah, Brandon T. Smith, Jonathan Shum, James C. Melville, Issa A. Hanna, Nagi 6726 Increasing population size can inhibit cumulative Demian, Tang Ho, Anthony Ratcliffe, Jeroen J. J. P. cultural evolution van den Beucken, John A. Jansen, Mark E. Wong, Nicolas Fay, Naomi De Kleine, Bradley Walker, and Antonios G. Mikos and Christine A. Caldwell

Contents PNAS u April 2, 2019 u vol. 116 u no. 14 u v Downloaded by guest on October 1, 2021 SOCIAL SCIENCES BIOPHYSICS AND COMPUTATIONAL BIOLOGY 6548 Variations of wealth resemblance by family 6560 A minimal-length approach unifies rigidity in relationship types in modern Chinese families underconstrained materials C. Y. Cyrus Chu, Kamhon Kan, and Jou Chun Lin Matthias Merkel, Karsten Baumgarten, Brian P. Tighe, See QnAs on page 6517 and M. Lisa Manning 6732 Computer science skills across China, India, Russia, 6594 Heterogeneous and rate-dependent streptavidin– and the United States biotin unbinding revealed by high-speed force Prashant Loyalka, Ou Lydia Liu, Guirong Li, Igor Chirikov, Elena spectroscopy and atomistic simulations Kardanova, Lin Gu, Guangming Ling, Ningning Yu, Fei Guo, Felix Rico, Andreas Russek, Laura Gonza´lez, Helmut Liping Ma, Shangfeng Hu, Angela Sun Johnson, Ashutosh Grubmu¨ller, and Simon Scheuring Bhuradia, Saurabh Khanna, Isak Froumin, Jinghuan Shi, 6608 Volumetric chemical imaging by clearing-enhanced Pradeep Kumar Choudhury, Tara Beteille, Francisco stimulated Raman scattering microscopy Marmolejo, and Namrata Tognatta Mian Wei, Lingyan Shi, Yihui Shen, Zhilun Zhao, Asja Guzman, Laura J. Kaufman, Lu Wei, and Wei Min SUSTAINABILITY SCIENCE 6790 Strong triaxial coupling and anomalous Poisson effect 6737 An integrated bioeconomic local economy-wide in collagen networks assessment of the environmental impacts of Ehsan Ban, Hailong Wang, J. Matthew Franklin, Jan T. Liphardt, poverty programs Paul A. Janmey, and Vivek B. Shenoy Ted E. Gilliland, James N. Sanchirico, and J. Edward Taylor 6800 Cryo-EM structures of Helicobacter pylori 6743 Public perceptions of the health risks of extreme heat vacuolating cytotoxin A oligomeric assemblies across US states, counties, and neighborhoods at near-atomic resolution Peter D. Howe, Jennifer R. Marlon, Xinran Wang, Kaiming Zhang, Huawei Zhang, Shanshan Li, Grigore D. and Anthony Leiserowitz Pintilie, Tung-Chung Mou, Yuanzhu Gao, Qinfen Zhang, Henry van den Bedem, Michael F. Schmid, Shannon Wing Ngor Au, and Wah Chiu BIOLOGICAL SCIENCES 6806 Networks of electrostatic and hydrophobic ANTHROPOLOGY interactions modulate the complex folding free energy surface of a designed βα protein 6749 Evidence that prenatal testosterone transfer from male twins reduces the fertility and socioeconomic Sujit Basak, R. Paul Nobrega, Davide Tavella, Laura M. Deveau, Nobuyasu Koga, Rie Tatsumi-Koga, David Baker, Francesca success of their female co-twins Massi, and C. Robert Matthews Aline Bu¨tikofer, David N. Figlio, Krzysztof Karbownik, Christopher W. Kuzawa, and Kjell G. Salvanes 6812 Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies APPLIED BIOLOGICAL SCIENCES Swetha Raman, Melissa Beilschmidt, Minh To, Kevin Lin, 6754 Multiplex targeted mass spectrometry assay for Francine Lui, Yazen Jmeian, Mark Ng, Minerva Fernandez, Ying one-shot flavivirus diagnosis Fu, Keith Mascall, Alejandro Duque, Xiaowei Wang, Guohua Sheena Wee, Asfa Alli-Shaik, Relus Kek, Hannah L. F. Swa, Pan, Stephane Angers, Jason Moffat, Sachdev S. Sidhu, Jeanne Wei-Ping Tien, Vanessa W. Lim, Yee-Sin Leo, Lee-Ching Ng, Magram, Angus M. Sinclair, Johan Fransson, Hapuarachchige C. Hapuarachchi, and Jayantha Gunaratne and Jean-Philippe Julien 6818 Defining a new nomenclature for the structures of BIOCHEMISTRY active and inactive kinases 6760 Substrate binding mode and catalytic mechanism of Vivek Modi and Roland L. Dunbrack Jr. human heparan sulfate D-glucuronyl C5 epimerase 6828 Revealing the mechanism of how cardiac Claire Debarnot, Yoan R. Monneau, Ve´ronique Roig-Zamboni, myosin-binding protein C N-terminal fragments Vincent Delauzun, Christine Le Narvor, Emeline Richard, sensitize thin filaments for myosin binding Je´roˆmeHe´nault, Adeline Goulet, Firas Fadel, Romain R. Vive`s, Alessio V. Inchingolo, Samantha Beck Previs, Michael J. Previs, Bernard Priem, David Bonnaffe´, Hugues Lortat-Jacob, David M. Warshaw, and Neil M. Kad and Yves Bourne

6766 Structural and mechanistic insights into CELL BIOLOGY mechanoactivation of focal adhesion kinase 6836 ATP7A delivers copper to the lysyl oxidase family Magnus Sebastian Bauer, Fabian Baumann, Csaba of enzymes and promotes tumorigenesis Daday, Pilar Redondo, Ellis Durner, Markus Andreas Jobst, Lukas Frederik Milles, Davide Mercadante, Diana Angela and metastasis Pippig, Hermann Eduard Gaub, Frauke Gra¨ter, Vinit Shanbhag, Kimberly Jasmer-McDonald, Sha Zhu, and Daniel Lietha Adam L. Martin, Nikita Gudekar, Aslam Khan, Erik Ladomersky, Kamlendra Singh, Gary A. Weisman, 6775 Structural and dynamical rationale for fatty acid and Michael J. Petris unsaturation in Escherichia coli 6842 Lysosome inhibition sensitizes pancreatic cancer to Greg J. Dodge, Ashay Patel, Kara L. Jaremko, J. Andrew McCammon, Janet L. Smith, and Michael D. Burkart replication stress by aspartate depletion Irmina A. Elliott, Amanda M. Dann, Shili Xu, Stephanie S. Kim, 6784 Transcriptome-wide profiling of multiple RNA Evan R. Abt, Woosuk Kim, Soumya Poddar, Alexandra Moore, modifications simultaneously at single- Lei Zhou, Jennifer L. Williams, Joseph R. Capri, Razmik base resolution Ghukasyan, Cynthia Matsumura, D. Andrew Tucker, Wesley R. Vahid Khoddami, Archana Yerra, Timothy L. Mosbruger, Armstrong, Anthony E. Cabebe, Nanping Wu, Luyi Li, Thuc M. Aaron M. Fleming, Cynthia J. Burrows, and Bradley R. Cairns Le, Caius G. Radu, and Timothy R. Donahue

vi u www.pnas.org Contents Downloaded by guest on October 1, 2021 6848 Bipotent stem cells support the cyclical regeneration IMMUNOLOGY AND INFLAMMATION of endometrial epithelium of the murine uterus 6932 Development of highly potent glucocorticoids for Shiying Jin steroid-resistant severe asthma 6858 Growth factor stimulation promotes multivesicular Yuanzheng He, Jingjing Shi, Quang Tam Nguyen, Erli endosome biogenesis by prolonging recruitment You, Hongbo Liu, Xin Ren, Zhongshan Wu, Jianshuang Li, of the late-acting ESCRT machinery Wenli Qiu, Sok Kean Khoo, Tao Yang, Wei Yi, Feng Sun, Zhijian Xi, Xiaozhu Huang, Karsten Melcher, Booki Min, Kyle B. Quinney, Elisa B. Frankel, Raakhee Shankar, William and H. Eric Xu Kasberg, Peter Luong, and Anjon Audhya 6938 Gene activation precedes DNA demethylation in 6868 PTEN arginine methylation by PRMT6 suppresses response to infection in human dendritic cells PI3K–AKT signaling and modulates pre- Alain Pacis, Florence Mailhot-Le´onard, Ludovic Tailleux, mRNA splicing Haley E. Randolph, Vania Yotova, Anne Dumaine, Jiawen Feng, Yaping Dang, Weiqi Zhang, Xuyang Zhao, Cong Jean-Christophe Grenier, and Luis B. Barreiro Zhang, Zhiyuan Hou, Yan Jin, Michael A. McNutt, Andrew R. Marks, and Yuxin Yin 6944 Unifying structural signature of eukaryotic α-helical host defense peptides DEVELOPMENTAL BIOLOGY Nannette Y. Yount, David C. Weaver, Ernest Y. Lee, Michelle W. Lee, Huiyuan Wang, Liana C. Chan, Gerard C. L. 6878 Growth and morphogenesis of the gastropod shell Wong, and Michael R. Yeaman Adam B. Johnson, Nina S. Fogel, and J. David Lambert 6884 Instructive role of melanocytes during pigment pattern formation of the avian skin MEDICAL SCIENCES Masafumi Inaba, Ting-Xin Jiang, Ya-Chen Liang, 6954 Biomaterials-aided mandibular reconstruction using Stephanie Tsai, Yung-Chih Lai, Randall Bruce Widelitz, in vivo bioreactors and Cheng Ming Chuong Alexander M. Tatara, Gerry L. Koons, Emma Watson, Trenton C. Piepergerdes, Sarita R. Shah, Brandon T. Smith, ECOLOGY Jonathan Shum, James C. Melville, Issa A. Hanna, Nagi Demian, Tang Ho, Anthony Ratcliffe, Jeroen J. J. P. 6891 Changes in belowground biodiversity during van den Beucken, John A. Jansen, Mark E. Wong, ecosystem development and Antonios G. Mikos Manuel Delgado-Baquerizo, Richard D. Bardgett, Peter M. Vitousek, Fernando T. Maestre, Mark A. Williams, David J. 6964 Deprivation of glutamine in cell culture reveals its Eldridge, Hans Lambers, Sigrid Neuhauser, Antonio Gallardo, potential for treating cancer Laura Garcı´a-Vela´zquez, Osvaldo E. Sala, Sebastia´n R. Harry Rubin Abades, Fernando D. Alfaro, Asmeret A. Berhe, Matthew A. 6969 In vitro analyses of suspected arrhythmogenic thin Bowker, Courtney M. Currier, Nick A. Cutler, Stephen C. Hart, Patrick E. Hayes, Zeng-Yei Hseu, Martin Kirchmair, Victor M. filament variants as a cause of sudden cardiac Pen˜a-Ramı´rez, Cecilia A. Pe´rez, Sasha C. Reed, Fernanda death in infants Santos, Christina Siebe, Benjamin W. Sullivan, Luis Sanam Shafaattalab, Alison Yueh Li, Eric Lin, Charles M. Weber-Grullon, and Noah Fierer Stevens, Laura J. Dewar, Francis C. Lynn, Shubhayan Sanatani, Zachary Laksman, Ryan D. Morin, Filip van Petegem, Leif Hove-Madsen, D. Peter Tieleman, Jonathan P. Davis, ENVIRONMENTAL SCIENCES and Glen F. Tibbits 6897 Pyrite formation from FeS and H2S is mediated through microbial redox activity 6975 Elevated signature of a gene module coexpressed Joana Thiel, James M. Byrne, Andreas Kappler, Bernhard with CDC20 marks genomic instability in glioma Schink, and Michael Pester Yunqiu Zhang, Jiuyi Li, Kaikai Yi, Jing Feng, Zhengmin Cong, Zheng Wang, Yanfei Wei, Fan Wu, Wen Cheng, Ayaz Ali Samo, Paolo Salomoni, Qiong Yang, Yu Huang, Chunsheng Kang, EVOLUTION Tao Jiang, and Xiaolong Fan 6903 Antiquity of forelimb ecomorphological diversity in – the mammalian stem lineage (Synapsida) 6985 Triggering of a Dll4 Notch1 loop impairs wound Jacqueline K. Lungmus and Kenneth D. Angielczyk healing in diabetes Xiaowei Zheng (郑晓伟), Sampath Narayanan, Vivekananda 6908 Transposable elements drive rapid phenotypic Gupta Sunkari, Sofie Eliasson, Ileana Ruxandra Botusan, Jacob variation in Capsella rubella Gru¨nler, Anca Irinel Catrina, Freddy Radtke, Cheng Xu, Xiao-Min Niu, Yong-Chao Xu, Zi-Wen Li, Yu-Tao Bian, Xing-Hui Allan Zhao, Neda Rajamand Ekberg, Urban Lendahl, Hou, Jia-Fu Chen, Yu-Pan Zou, Juan Jiang, Qiong Wu, Song and Sergiu-Bogdan Catrina Ge, Sureshkumar Balasubramanian, and Ya-Long Guo 6995 Age-related inflammation triggers skeletal 6914 Principles of plastid reductive evolution illuminated stem/progenitor cell dysfunction by nonphotosynthetic chrysophytes Anne Marie Josephson, Vivian Bradaschia-Correa, Sooyeon Richard G. Dorrell, Tomonori Azuma, Mami Nomura, Lee, Kevin Leclerc, Karan S. Patel, Emma Muinos Lopez, Guillemette Audren de Kerdrel, Lucas Paoli, Shanshan Yang, Hannah P. Litwa, Shane S. Neibart, Manasa Kadiyala, Chris Bowler, Ken-ichiro Ishii, Hideaki Miyashita, Gillian H. Gile, Madeleine Z. Wong, Matthew M. Mizrahi, Nury L. Yim, and Ryoma Kamikawa Austin J. Ramme, Kenneth A. Egol, and Philipp Leucht 7005 p27 transcriptionally coregulates cJun to drive GENETICS programs of tumor progression 6924 Exaggerated heterochiasmy in a fish with sex-linked Hyunho Yoon, Minsoon Kim, Kibeom Jang, Miyoung Shin, male coloration polymorphisms Alexandra Besser, Xue Xiao, Dekuang Zhao, Seth A. Roberta Bergero, Jim Gardner, Beth Bader, Lengxob Yong, Wander, Karoline Briegel, Lluis Morey, Andy Minn, and Deborah Charlesworth and Joyce M. Slingerland

Contents PNAS u April 2, 2019 u vol. 116 u no. 14 u vii Downloaded by guest on October 1, 2021 MICROBIOLOGY 7077 Glucocorticoid enhancement of recognition memory 7015 Lysyl-tRNA synthetase as a drug target in malaria via basolateral amygdala-driven facilitation of and cryptosporidiosis prelimbic cortex interactions Beatriz Baragan˜a, Barbara Forte, Ryan Choi, Stephen Areg Barsegyan, Gabriele Mirone, Giacomo Ronzoni, Chunan Nakazawa Hewitt, Juan A. Bueren-Calabuig, Joa˜o Pedro Guo, Qi Song, Daan van Kuppeveld, Evelien H. S. Schut, Piray Pisco, Caroline Peet, David M. Dranow, David A. Robinson, Atsak, Selina Teurlings, James L. McGaugh, Dirk Schubert, Chimed Jansen, Neil R. Norcross, Sumiti Vinayak, Mark and Benno Roozendaal Anderson, Carrie F. Brooks, Caitlin A. Cooper, Sebastian 7083 Key role of soluble epoxide hydrolase in the Damerow, Michael Delves, Karen Dowers, James Duffy, neurodevelopmental disorders of offspring after Thomas E. Edwards, Irene Hallyburton, Benjamin G. Horst, Matthew A. Hulverson, Liam Ferguson, Marı´a Bele´n maternal immune activation Jime´nez-Dı´az, Rajiv S. Jumani, Donald D. Lorimer, Melissa S. Min Ma, Qian Ren, Jun Yang, Kai Zhang, Zhongwei Love, Steven Maher, Holly Matthews, Case W. McNamara, Xiong, Tamaki Ishima, Yaoyu Pu, Sung Hee Hwang, Peter Miller, Sandra O’Neill, Kayode K. Ojo, Maria Manabu Toyoshima, Yoshimi Iwayama, Yasuko Osuna-Cabello, Erika Pinto, John Post, Jennifer Riley, Matthias Hisano, Takeo Yoshikawa, Bruce D. Hammock, Rottmann, Laura M. Sanz, Paul Scullion, Arvind Sharma, and Kenji Hashimoto Sharon M. Shepherd, Yoko Shishikura, Frederick R. C. 7089 Gliogenesis in the outer subventricular zone Simeons, Erin E. Stebbins, Laste Stojanovski, Ursula Straschil, promotes enlargement and gyrification of Fabio K. Tamaki, Jevgenia Tamjar, Leah S. Torrie, Ame´lie the primate cerebrum Vantaux, Benoıˆt Witkowski, Sergio Wittlin, Manickam Yogavel, Fabio Zuccotto, In˜igo Angulo-Barturen, Robert Sinden, Jake Brian G. Rash, Alvaro Duque, Yury M. Morozov, Jon I. Arellano, Baum, Francisco-Javier Gamo, Pascal Ma¨ser, Dennis E. Kyle, Nicola Micali, and Pasko Rakic Elizabeth A. Winzeler, Peter J. Myler, Paul G. Wyatt, David 7095 Working memory capacity is enhanced by distributed Floyd, David Matthews, Amit Sharma, Boris Striepen, prefrontal activation and invariant Christopher D. Huston, David W. Gray, Alan H. Fairlamb, temporal dynamics Andrei V. Pisliakov, Chris Walpole, Kevin D. Read, Wesley C. Van Voorhis, and Ian H. Gilbert Hua Tang, Xue-Lian Qi, Mitchell R. Riley, and Christos Constantinidis 7021 Social cheating in a Pseudomonas aeruginosa 7101 Evolutionary expansion of connectivity between quorum-sensing variant multimodal association areas in the human Ruiyi Chen, Eric De´ziel, Marie-Christine Groleau, Amy L. Schaefer, and E. Peter Greenberg brain compared with chimpanzees Dirk Jan Ardesch, Lianne H. Scholtens, Longchuan See Commentary on page 6525 Li, Todd M. Preuss, James K. Rilling, 7027 Evolution of the Pseudomonas aeruginosa and Martijn P. van den Heuvel quorum-sensing hierarchy 7107 Reciprocal modulation of 5-HT and octopamine Maxim Kostylev, Daniel Y. Kim, Nicole E. Smalley, Indraneel regulates pumping via feedforward and feedback Salukhe, E. Peter Greenberg, and Ajai A. Dandekar circuits in C. elegans See Commentary on page 6525 Hui Liu, Li-Wei Qin (秦丽玮), Rong Li (李蓉), Ce Zhang (张策), 7033 PTPN14 degradation by high-risk human Umar Al-Sheikh, and Zheng-Xing Wu (吴政星) papillomavirus E7 limits keratinocyte differentiation 7113 Synaptic retinoic acid receptor signaling mediates and contributes to HPV-mediated oncogenesis mTOR-dependent metaplasticity that controls Joshua Hatterschide, Amelia E. Bohidar, Miranda Grace, hippocampal learning Tara J. Nulton, Hee Won Kim, Brad Windle, Iain M. Morgan, Yu-Tien Hsu, Jie Li, Dick Wu, Thomas C. Su¨dhof, and Lu Chen Karl Munger, and Elizabeth A. White See Commentary on page 6528 7043 OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism PHARMACOLOGY Xiaofei E, Paul Meraner, Ping Lu, Jill M. Perreira, Aaron M. Aker, 7123 Molecular dynamics-guided discovery of an William M. McDougall, Ronghua Zhuge, Gary C. Chan, ago-allosteric modulator for GPR40/FFAR1 Rachel M. Gerstein, Patrizia Caposio, Andrew D. Yurochko, Michael Lu¨ckmann, Mette Trauelsen, Marie A. Abraham L. Brass, and Timothy F. Kowalik Bentsen, Tinne A. D. Nissen, Joao Martins, Zohreh 7053 Transcriptome profiling of Plasmodium vivax in Fallah, Mads M. Nygaard, Elena Papaleo, Saimiri monkeys identifies potential ligands Kresten Lindorff-Larsen, Thue W. Schwartz, for invasion and Thomas M. Frimurer Karthigayan Gunalan, Juliana M. Sa´, Roberto R. Moraes Barros, 7129 From single drug targets to synergistic network Sarah L. Anzick, Ramoncito L. Caleon, J. Patrick Mershon, pharmacology in ischemic stroke Kishore Kanakabandi, Monica Paneru, Kimmo Virtaneva, Craig Ana I. Casas, Ahmed A. Hassan, Simon J. Larsen, Vanessa Martens, John W. Barnwell, Jose M. Ribeiro, and Louis H. Miller Gomez-Rangel, Mahmoud Elbatreek, Pamela W. M. Kleikers, 7062 Glycoconjugate vaccine using a genetically modified Emre Guney, Javier Egea, Manuela G. Lo´pez, Jan Baumbach, O antigen induces protective antibodies to and Harald H. H. W. Schmidt Francisella tularensis Giuseppe Stefanetti, Nihal Okan, Avner Fink, Erica Gardner, PLANT BIOLOGY and Dennis L. Kasper 7137 Genome of Crucihimalaya himalaica, a close relative of Arabidopsis, shows ecological adaptation to NEUROSCIENCE high altitude 7071 Structural maturation of cortical perineuronal nets Ticao Zhang, Qin Qiao, Polina Yu. Novikova, Qia Wang, and their perforating synapses revealed by Jipei Yue, Yanlong Guan, Shengping Ming, Tianmeng Liu, superresolution imaging Ji De, Yixuan Liu, Ihsan A. Al-Shehbaz, Hang Sun, Marc Yaron M. Sigal, Haneui Bae, Luke J. Bogart, Takao K. Hensch, Van Montagu, Jinling Huang, Yves Van de Peer, and Xiaowei Zhuang and La Qiong

viii u www.pnas.org Contents Downloaded by guest on October 1, 2021 SUSTAINABILITY SCIENCE PSYCHOLOGICAL AND COGNITIVE SCIENCES 6673 Emergence of robust precipitation changes across 7148 Examining long-term trends in politics and culture crop production areas in the 21st century through language of political leaders and Maisa Rojas, Fabrice Lambert, Julian Ramirez-Villegas, cultural institutions and Andrew J. Challinor Kayla N. Jordan, Joanna Sterling, James W. Pennebaker, and Ryan L. Boyd

SOCIAL SCIENCES CORRECTIONS 7149 A network’s gender composition and communication pattern predict women’s leadership success ENVIRONMENTAL SCIENCES Yang Yang, Nitesh V. Chawla, and Brian Uzzi 7147 Visualizing the iron atom exchange front in the Fe(II)-catalyzed recrystallization of goethite PLANT BIOLOGY by atom probe tomography 7150 Impaired respiration discloses the physiological Sandra D. Taylor, Jia Liu, Xin Zhang, Bruce W. Arey, Libor significance of state transitions in Chlamydomonas Kovarik, Daniel K. Schreiber, Daniel E. Perea, Pierre Cardol, Jean Alric, Jacqueline Girard-Bascou, Fabrice and Kevin M. Rosso Franck, Francis-Andre´ Wollman, and Giovanni Finazzi

Contents PNAS u April 2, 2019 u vol. 116 u no. 14 u ix Downloaded by guest on October 1, 2021