IME $6.7 Million Bioengineering Grant the Quad
UNIVERSITY of PENNSYLVANIA Tuesday, October 16, 2001 Volume 48 Number 8 www.upenn.edu/almanac/ IME $6.7 Million Bioengineering Grant The Quad: Spruce, Woodland and Ware The NIH National Heart Lung and Blood Institute has awarded an Next fall, the completed Quad interdisciplinary research grant to Institute for Medicine and Engineer- will boast three Houses, each with ing (IME) investigators led by Dr. Peter F. Davies. The grant, totaling its own courtyard, lobby, mailroom, $6.7 million over five years, focuses on the biomechanics of cardio- exercise room, library, seminar vascular cells, membranes, and molecules with emphasis on how these rooms, computer labs and refur- properties determine and control cardiovascular tissue function. The bished student rooms. “The Quad’s partnership is composed of two interactive components: fundamental system of courtyards naturally sup- cell and molecular investigations of cardiovascular mechanotrans- ports a division of three—the archi- duction, and preclinical studies of engineered arteries, heart valve tects and the planning committee of calcification, and microcoil treatment of intracranial aneurysms. students, faculty and staff saw that Complementary experimental approaches that are both design- right away when they looked closely driven and hypothesis-driven include geometric constraints, spatial at the Quad,” noted Dr. David analyses, protein conformational changes, deformation properties of Brownlee, director of the College molecules and membranes, and mass transport characteristics that Houses. regulate vascular cell structure, gene expression, function, and malad- The present four Houses in the aptation to blood flow forces leading to pathological change. Quadrangle—Community, The integrative group of IME investigators is Dr. Peter F. Davies, Goldberg, Spruce and Ware—will director, IME, professor of pathology and laboratory medicine, SOM, be replaced beginning in the fall and bioengineering, SEAS; Dr.
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