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INTERNATIONAL TABLES FOR CRYSTALLOGRAPHY Volume F CRYSTALLOGRAPHY OF BIOLOGICAL MACROMOLECULES Edited by MICHAEL G. ROSSMANN AND EDDY ARNOLD Advisors and Advisory Board Advisors: J. Drenth, A. Liljas. Advisory Board: U. W. Arndt, E. N. Baker, S. C. Harrison, W. G. J. Hol, K. C. Holmes, L. N. Johnson, H. M. Berman, T. L. Blundell, M. Bolognesi, A. T. Brunger, C. E. Bugg, K. K. Kannan, S.-H. Kim, A. Klug, D. Moras, R. J. Read, R. Chandrasekaran, P. M. Colman, D. R. Davies, J. Deisenhofer, T. J. Richmond, G. E. Schulz, P. B. Sigler,² D. I. Stuart, T. Tsukihara, R. E. Dickerson, G. G. Dodson, H. Eklund, R. GiegeÂ,J.P.Glusker, M. Vijayan, A. Yonath. Contributing authors E. E. Abola: The Department of Molecular Biology, The Scripps Research W. Chiu: Verna and Marrs McLean Department of Biochemistry and Molecular Institute, La Jolla, CA 92037, USA. [24.1] Biology, Baylor College of Medicine, Houston, Texas 77030, USA. [19.2] P. D. Adams: The Howard Hughes Medical Institute and Department of Molecular J. C. Cole: Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge Biophysics and Biochemistry, Yale University, New Haven, CT 06511, USA. CB2 1EZ, England. [22.4] [18.2, 25.2.3] M. L. Connolly: 1259 El Camino Real #184, Menlo Park, CA 94025, USA. F. H. Allen: Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge [22.1.2] CB2 1EZ, England. [22.4, 24.3] K. D. Cowtan: Department of Chemistry, University of York, York YO1 5DD, U. W. Arndt: Laboratory of Molecular Biology, Medical Research Council, Hills England. -
AHMED H. ZEWAIL 26 February 1946 . 2 August 2016
AHMED H. ZEWAIL 26 february 1946 . 2 august 2016 PROCEEDINGS OF THE AMERICAN PHILOSOPHICAL SOCIETY VOL. 162, NO. 2, JUNE 2018 biographical memoirs t is often proclaimed that a stylist is someone who does and says things in memorable ways. From an analysis of his experimental Iprowess, his written contributions, his lectures, and even from the details of the illustrations he used in his published papers or during his lectures to scientific and other audiences, Ahmed Zewail, by this or any other definition, was a stylist par excellence. For more than a quarter of a century, I interacted with Ahmed (and members of his family) very regularly. Sometimes he and I spoke several times a week during long-distance calls. Despite our totally different backgrounds we became the strongest of friends, and we got on with one another like the proverbial house on fire. We collaborated scientifi- cally and we adjudicated one another’s work, as well as that of others. We frequently exchanged culturally interesting stories. We each relished the challenge of delivering popular lectures. In common with very many others, I deem him to be unforgettable, for a variety of different reasons. He was one of the intellectually ablest persons that I have ever met. He possessed elemental energy. He executed a succession of brilliant experiments. And, almost single-handedly, he created the subject of femtochemistry, with all its magnificent manifestations and ramifications. From the time we first began to exchange ideas, I felt a growing affinity for his personality and attitude. This was reinforced when I told him that, ever since I was a teenager, I had developed a deep interest in Egyptology and a love for modern Egypt. -
Cambridge's 92 Nobel Prize Winners Part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin
Cambridge's 92 Nobel Prize winners part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin By Cambridge News | Posted: January 18, 2016 By Adam Care The News has been rounding up all of Cambridge's 92 Nobel Laureates, celebrating over 100 years of scientific and social innovation. ADVERTISING In this installment we move from 1951 to 1974, a period which saw a host of dramatic breakthroughs, in biology, atomic science, the discovery of pulsars and theories of global trade. It's also a period which saw The Eagle pub come to national prominence and the appearance of the first female name in Cambridge University's long Nobel history. The Gender Pay Gap Sale! Shop Online to get 13.9% off From 8 - 11 March, get 13.9% off 1,000s of items, it highlights the pay gap between men & women in the UK. Shop the Gender Pay Gap Sale – now. Promoted by Oxfam 1. 1951 Ernest Walton, Trinity College: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei 2. 1951 John Cockcroft, St John's / Churchill Colleges: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei Walton and Cockcroft shared the 1951 physics prize after they famously 'split the atom' in Cambridge 1932, ushering in the nuclear age with their particle accelerator, the Cockcroft-Walton generator. In later years Walton returned to his native Ireland, as a fellow of Trinity College Dublin, while in 1951 Cockcroft became the first master of Churchill College, where he died 16 years later. 3. 1952 Archer Martin, Peterhouse: Nobel Prize in Chemistry, for developing partition chromatography 4. -
John Meurig Thomas
obituary John Meurig Thomas (1932–2020) Sir John Meurig Thomas, who was one of the leading materials and catalytic scientists of his generation, sadly died in November 2020, aged 87. homas was born in Wales, the son of a enabling him to study one of the most coal miner, and his early life was spent significant conceptual developments in Tin the Gwendraeth Valley in South catalysis over the last decades — single-site Wales; throughout his life he remained catalysis. Thomas was an early explorer in passionately committed to his native developing this new field. His work land, its language and literature. He was focussed on using mesoporous silica both an undergraduate and postgraduate MCM-41 as a support or tether for new student at Swansea University and after single-site catalysts. MCM-41 provided a brief postdoctoral period at the Atomic ordered mesopores that could be tuned Weapons Establishment, Aldermaston, in diameter, thereby adding a degree of he was appointed a Lecturer at Bangor confinement for the single-site catalysts. University and subsequently Professor at Working with Maschmeyer, Sankar and Aberystwyth University. In 1978 he Credit: Kevin Quinlan / University of Delaware Rey, a landmark publication appeared in moved to the University of Cambridge 19957 in which metallocenes were grafted as Professor of Physical Chemistry and onto the walls of MCM-41 and were shown subsequently to London, where he was measurements of both long-range and to be a highly effective epoxidation catalyst Director of the Royal Institution from local structure on the same sample under for cyclohexene and pinene 1986–1991 — an ideal role for him as it identical reaction conditions. -
Welsh Acheivements Brochure
WELSH ACHIEVEMENTS [ IN SCIENCE, TECHNOLOGY AND ENGINEERING ] ‘Our vision in Wales is of a learning country, where highly- skilled and highly-qualified people are employed in high- technology, high added-value companies.’ Professor John Harries, first chief scientific adviser for Wales, speaking in 2011 at the Welsh universities collaboration, research knowledge and expertise programme – Welsh Crucible. This publication is also available electronically from business.wales.gov.uk/innovation To discuss your innovation needs please call Business Wales on 03000 6 03000 or visit business.wales.gov.uk. Print ISBN 978 1 4734 0171 6 Printed on recycled paper Digital ISBN 978 1 4734 0169 3 WG16613 / G/MH/4578 / 0813 © Crown copyright 2013 2 On a global scale Wales is a small, but smart country, in which every opportunity has been taken to optimise resources, designs and processes. Shaped by landscape and culture it made its mark on the world through the maximisation of the great natural mineral wealth found here. Wales continues to make its mark through in-depth scientific and technical understanding and commercial innovation. From the past to the present an impressive list of achievements, many of which are the first of their kind in the world, have given Wales a great momentum for the future. CONTENTS 02 Foreword 05 Bioscience and Health 13 The Built Environment 20 Telecommunications and ICT 26 Creative Industries 35 Energy 41 Engineering 45 Environmental Sciences 50 Materials 56 Transport 64 People 74 Milestones 86 Conclusion 1 The modern world is increasingly made up of the products of the application of science, technology and engineering. -
Crystal Vision Dorothy Hodgkin & the Nobel Prize “Few Were Her Equal in Generosity of Spirit, Breadth of Mind, Cultivated Humaneness, Or Gift for Giving
Crystal Vision Dorothy Hodgkin & the Nobel Prize “Few were her equal in generosity of spirit, breadth of mind, cultivated humaneness, or gift for giving. She should be remembered not only for a lifetime’s succession of brilliantly achieved structures. While those who knew her, experienced her quiet and modest and extremely powerful influence, learned from her more than the positioning of atoms in the three-dimensional molecule, she will be remembered not only with respect, and reverence, and gratitude, but more than anything else, with love. Let that be her lasting memorial.” Anne Sayre, in the Autumn 1995 Newsletter of the American Crystallographic Association Cover image © Emilio Segre Visual Archives/American Institute of Physics/Science Photo Library Letter from the Principal Dr Alice Prochaska, Somerville College Many remarkable woman scientists have passed through Somerville, but few rival Dorothy Hodgkin, whose path-breaking work in crystallography showed a mind not only attuned to high science but one also able to envision a crystal structure from the pattern made by its X-ray diffraction. Her ability to ‘see’ molecules such as cholesterol, penicillin, vitamin B and insulin transformed her field. 2014 sees the fiftieth anniversary of Professor Hodgkin’s Nobel prize. It is also the International Year of Crystallography, marking the 100th anniversary of Max von Laue’s Nobel Prize for Physics, awarded for his discovery that X-rays could be diffracted by crystals. That discovery underpinned Dorothy Hodgkin’s work. We are proud that Somerville supported her at a time when there was widespread opposition to married women pursuing academic careers. -
Chem Newsletter Fall 04.Pdf
Department of Chemistry Oregon State University Corvallis, OR 97331 www.chemistry.oregonstate.edu 541-737-2081 Chemistry Newsletter Volume 24 - Fall 2004 Oregon Research Center Opens The Chemistry Department is an active partner in Oregon’s new joint research cen- ter, the Oregon Nanoscience and Microtechnologies Institute (ONAMI), which was dedicated in May by a host of dignitaries, including Governor Ted Kulongoski and Senator Ron Wyden. ONAMI is an unprecedented collaboration between the state’s three major research universities, Pacific Northwest National Laboratory, the State of Oregon, and private industry. Industrial partners include such Oregon giants as Hewlett-Packard Co., Intel, Tektronics, FEI Company, and Electro Scientific Indus- tries. Chemistry Professor Vince Remcho became involved with ONAMI through his participation in the OSU/PNNL Microproducts Breakthrough Institute. Part of the ONAMI concept is to encourage small business growth in the Oregon high-tech sec- tor. The ONAMI facility at HP will be an incubator for OSU/UO/PSU interactions with small business start-ups; space will be available for these businesses to under- take work of mutual interest to ONAMI principals. It will be located in Building 11 of the Hewlett-Packard Company’s Corvallis campus for two to three years, until the OSU ONAMI team can move in to a renovated Graf Hall. Research at ONAMI should bring millions of federal research dollars to Oregon and could give Oregon the national recognition it deserves in the world of nanotech- nology and microscale research and development. Remcho comments, “This is an inviting environment to work in as a researcher, and I hope that it will be a means of involving graduate and undergraduate students in work that leads to employment op- portunities. -
RSC Branding
Royal Society of Chemistry National Chemical Landmarks Award Honouree Location Inscription Date The Institute of Cancer Research, Chester ICR scientists on this site and elsewhere pioneered numerous new cancer drugs from 10 Institute of Cancer Beatty Laboratories, 237 the 1950s until the present day – including the discovery of chemotherapy drug December Research Fulham Road, Chelsea carboplatin, prostate cancer drug abiraterone and the genetic targeting of olaparib for 2018 Road, London, SW3 ovarian and breast cancer. 6JB, UK The Institute of Cancer ICR scientists on this site and elsewhere pioneered numerous new cancer drugs from 10 Research, Royal Institute of Cancer the 1950s until the present day – including the discovery of chemotherapy drug December Marsden Hospital, 15 Research carboplatin, prostate cancer drug abiraterone and the genetic targeting of olaparib for 2018 Cotswold Road, Sutton, ovarian and breast cancer. London, SM2 5NG, UK Ape and Apple, 28-30 John Dalton Street was opened in 1846 by Manchester Corporation in honour of 26 October John Dalton Street, famous chemist, John Dalton, who in Manchester in 1803 developed the Atomic John Dalton 2016 Manchester, M2 6HQ, Theory which became the foundation of modern chemistry. President of Manchester UK Literary and Philosophical Society 1816-1844. Chemical structure of Near this site in 1903, James Colquhoun Irvine, Thomas Purdie and their team found 30 College Gate, North simple sugars, James a way to understand the chemical structure of simple sugars like glucose and lactose. September Street, St Andrews, Fife, Colquhoun Irvine and Over the next 18 years this allowed them to lay the foundations of modern 2016 KY16 9AJ, UK Thomas Purdie carbohydrate chemistry, with implications for medicine, nutrition and biochemistry. -
Max Ferdinand Perutz 1914–2002
OBITUARY Max Ferdinand Perutz 1914–2002 Max Ferdinand Perutz, who died on in the MRC Laboratory of Molecular 6 February, will be remembered as Biology, which has grown to house one of the 20th century’s scientific over 400 people. He published over giants. Often referred to as the ‘fa- 100 papers and articles during his re- ther of molecular biology’, his work tirement. Once asked why he didn’t re- remains one of the foundations on tire at 65 he replied that he was tied up which science is being built today. in some very interesting research at Born in Vienna in 1914, Max was the time. Until the Friday before educated in the Theresianum, a Christmas, he was active in the lab al- grammar school originating from most every day, submitting his last an earlier Officers’ academy. His paper just a few days before then. parents suggested that he study law Max’s scientific interests ranged far to prepare for entering the family beyond medical research. As a sideline, business, but he chose to study he also worked on glaciers in his chemistry at the University of youth. He studied the transformation Vienna. of snowflakes that fall on glaciers into In 1936, with financial support the huge single ice crystals that make from his father, he began a PhD at the Cavendish up its bulk, and the relationship between the mechanical Laboratory in Cambridge. Using X-ray crystallography he properties of ice measured in the laboratory and the mecha- aimed to determine the structure of hemoglobin. But the nism of glacier flow. -
Robert Burns Woodward
The Life and Achievements of Robert Burns Woodward Long Literature Seminar July 13, 2009 Erika A. Crane “The structure known, but not yet accessible by synthesis, is to the chemist what the unclimbed mountain, the uncharted sea, the untilled field, the unreached planet, are to other men. The achievement of the objective in itself cannot but thrill all chemists, who even before they know the details of the journey can apprehend from their own experience the joys and elations, the disappointments and false hopes, the obstacles overcome, the frustrations subdued, which they experienced who traversed a road to the goal. The unique challenge which chemical synthesis provides for the creative imagination and the skilled hand ensures that it will endure as long as men write books, paint pictures, and fashion things which are beautiful, or practical, or both.” “Art and Science in the Synthesis of Organic Compounds: Retrospect and Prospect,” in Pointers and Pathways in Research (Bombay:CIBA of India, 1963). Robert Burns Woodward • Graduated from MIT with his Ph.D. in chemistry at the age of 20 Woodward taught by example and captivated • A tenured professor at Harvard by the age of 29 the young... “Woodward largely taught principles and values. He showed us by • Published 196 papers before his death at age example and precept that if anything is worth 62 doing, it should be done intelligently, intensely • Received 24 honorary degrees and passionately.” • Received 26 medals & awards including the -Daniel Kemp National Medal of Science in 1964, the Nobel Prize in 1965, and he was one of the first recipients of the Arthur C. -
Max Perutz (1914–2002)
PERSONAL NEWS NEWS Max Perutz (1914–2002) Max Perutz died on 6 February 2002. He Nobel Prize for Chemistry in 1962 with structure is more relevant now than ever won the Nobel Prize for Chemistry in his colleague and his first student John as we turn attention to the smallest 1962 after determining the molecular Kendrew for their work on the structure building blocks of life to make sense of structure of haemoglobin, the red protein of haemoglobin (Perutz) and myoglobin the human genome and mechanisms of in blood that carries oxygen from the (Kendrew). He was one of the greatest disease.’ lungs to the body tissues. Perutz attemp- ambassadors of science, scientific method Perutz described his work thus: ted to understand the riddle of life in the and philosophy. Apart from being a great ‘Between September 1936 and May 1937 structure of proteins and peptides. He scientist, he was a very kindly and Zwicky took 300 or more photographs in founded one of Britain’s most successful tolerant person who loved young people which he scanned between 5000 and research institutes, the Medical Research and was passionately committed towards 10,000 nebular images for new stars. Council Laboratory of Molecular Bio- societal problems, social justice and This led him to the discovery of one logy (LMB) in Cambridge. intellectual honesty. His passion was to supernova, revealing the final dramatic Max Perutz was born in Vienna in communicate science to the public and moment in the death of a star. Zwicky 1914. He came from a family of textile he continuously lectured to scientists could say, like Ferdinand in The Tempest manufacturers and went to the Theresium both young and old, in schools, colleges, when he had to hew wood: School, named after Empress Maria universities and research institutes. -
Guides to the Royal Institution of Great Britain: 1 HISTORY
Guides to the Royal Institution of Great Britain: 1 HISTORY Theo James presenting a bouquet to HM The Queen on the occasion of her bicentenary visit, 7 December 1999. by Frank A.J.L. James The Director, Susan Greenfield, looks on Front page: Façade of the Royal Institution added in 1837. Watercolour by T.H. Shepherd or more than two hundred years the Royal Institution of Great The Royal Institution was founded at a meeting on 7 March 1799 at FBritain has been at the centre of scientific research and the the Soho Square house of the President of the Royal Society, Joseph popularisation of science in this country. Within its walls some of the Banks (1743-1820). A list of fifty-eight names was read of gentlemen major scientific discoveries of the last two centuries have been made. who had agreed to contribute fifty guineas each to be a Proprietor of Chemists and physicists - such as Humphry Davy, Michael Faraday, a new John Tyndall, James Dewar, Lord Rayleigh, William Henry Bragg, INSTITUTION FOR DIFFUSING THE KNOWLEDGE, AND FACILITATING Henry Dale, Eric Rideal, William Lawrence Bragg and George Porter THE GENERAL INTRODUCTION, OF USEFUL MECHANICAL - carried out much of their major research here. The technological INVENTIONS AND IMPROVEMENTS; AND FOR TEACHING, BY COURSES applications of some of this research has transformed the way we OF PHILOSOPHICAL LECTURES AND EXPERIMENTS, THE APPLICATION live. Furthermore, most of these scientists were first rate OF SCIENCE TO THE COMMON PURPOSES OF LIFE. communicators who were able to inspire their audiences with an appreciation of science.