bioRxiv preprint doi: https://doi.org/10.1101/818682; this version posted October 25, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Somatosensory corticospinal tract axons sprout within the cervical cord following a dorsal root/dorsal column spinal injury in the rat. Margaret M. McCann1,2, Karen M. Fisher1, Jamie Ahloy-Dallaire1,3, Corinna Darian-Smith1 1Department of Comparative Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA94305-5342 2Margaret M. McCann, Creighton University, Department of Biomedical Sciences, 2500 California Plaza, Criss II, Omaha NE 68178. 3Département des sciences animales, Université Laval, 2425 rue de l’Agriculture, Québec, Québec, Canada G1V 0A6 Corresponding and submitting author: Corinna Darian-Smith, PhD Tel.: 650 736 0969 Fax: 650 498 5085 E-mail:
[email protected] Running title: Corticospinal growth in rat cord lesion model Number of pages: 31 (includes everything) Number of figures: 7 Acknowledgements: This work was supported by the National Institute of Neurological Disorders and Stroke (R01 NS091031 to CD-S), and the Stanford Department of Comparative Medicine MLAS program. We would like to thank Joe Garner for his early guidance with statistics. 1 bioRxiv preprint doi: https://doi.org/10.1101/818682; this version posted October 25, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. Abstract and keywords The corticospinal tract (CST) is the major descending pathway controlling voluntary hand function in primates, and though less dominant, it mediates voluntary paw movements in rats.