DOCSLIB.ORG

Abstracts Genome 10K & Genome Science 29 Aug - 1 Sept 2017 Norwich Research Park, Norwich, Uk

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Abstracts Genome 10K & Genome Science 29 Aug - 1 Sept 2017 Norwich Research Park, Norwich, Uk Genome 10K c ABSTRACTS GENOME 10K & GENOME SCIENCE 29 AUG - 1 SEPT 2017 NORWICH RESEARCH PARK, NORWICH, UK Genome 10K c 48 KEYNOTE SPEAKERS ............................................................................................................................... 1 Dr Adam Phillippy: Towards the gapless assembly of complete vertebrate genomes .................... 1 Prof Kathy Belov: Saving the Tasmanian devil from extinction ......................................................... 1 Prof Peter Holland: Homeobox genes and animal evolution: from duplication to divergence ........ 2 Dr Hilary Burton: Genomics in healthcare: the challenges of complexity .......................................... 2 INVITED SPEAKERS ................................................................................................................................. 3 Vertebrate Genomics ........................................................................................................................... 3 Alex Cagan: Comparative genomics of animal domestication .......................................................... 3 Plant Genomics .................................................................................................................................... 4 Ksenia Krasileva: Evolution of plant Immune receptors ..................................................................... 4 Andrea Harper: Using Associative Transcriptomics to predict tolerance to ash dieback disease in European ash trees ............................................................................................................. 4 Microbial Genomics ............................................................................................................................. 5 John Lees: Scalable pan-genome-wide association studies in bacteria ........................................... 5 Gemma Langridge: Contaminant or infective agent? Re-classifying the staphylococci for modern medicine .................................................................................................................................. 6 Evolutionary Genomics ......................................................................................................................... 7 Emma Teeling: Growing old yet staying young: A genomic perspective on bats’ extraordinary longevity ......................................................................................................................... 7 Clinical and Translational Genomics .................................................................................................... 8 Joris Veltman: De novo mutations in genetic disease ....................................................................... 8 Matthew Hurles: Deciphering Developmental Disorders .................................................................... 8 Agricultural Genomics .......................................................................................................................... 9 Alan Archibald: Precision engineering for PRRSV resistance in pigs ................................................ 9 Nicola Patron: Engineering Plant Genomes for Farming and Pharming ........................................... 9 Conservation Genomics ..................................................................................................................... 10 Beth Shapiro: The genomic consequences of inbreeding in mountain lions, Puma concolor ....... 10 Developmental Biology ....................................................................................................................... 11 Kristin Tessmar-Raible: Genomic and transcriptomic approaches for the study of daily, monthly and seasonal timing ............................................................................................................. 11 Andrea Münsterberg: Cellular dynamics and lineage specification in developing somites ........... 12 Microbial Communities ...................................................................................................................... 13 Mads Albertsen: Towards a fully populated tree of life .................................................................... 13 Lindsay Hall: Early life microbial communities ................................................................................. 13 Sequencing Technology and Developments ....................................................................................... 14 Aaron McKenna: Information and storage recovery using the diversity of second- generation sequencing technologies ................................................................................................. 14 i Genome Informatics........................................................................................................................... 15 Doreen Ware: TBC ............................................................................................................................... 15 Population Genomics ......................................................................................................................... 16 Richard Durbin: Whole genome sequence studies of the Lake Malawi cichlid adaptive radiation ............................................................................................................................................... 16 Single Cell .......................................................................................................................................... 17 Muzlifah Haniffa: Deconstructing the immune system using single cell technologies .................. 17 Tamir Chandra: Understanding cellular heterogeneity in cellular senescence and ageing through single cell transcriptomics ................................................................................................... 17 Stephen Sansom: Transcript structures in the thymus: improvised or rehearsed? ........................ 18 ORAL PRESENTATIONS ......................................................................................................................... 19 Vertebrate Genomics ......................................................................................................................... 19 (O1/P61) Comparative whole-genome study of eleven Felidae species from six lineages ........... 19 (O2/P52) A Cross-Species Bioinformatics and FISH approach to physical mapping of Mammalian Genomes ........................................................................................................................ 20 (O3/P65) Expansion of gene families and signatures of selection in the Australian marsupials ........................................................................................................................................... 21 (O4) The tuatara genome project— Unlocking the genome of a living fossil .................................. 22 Plant Genomics .................................................................................................................................. 23 (O5/P19) The evolution of photosynthetic efficiency ....................................................................... 23 (O6/P24) Designing multi-genome graphs for crop genomics and genetics: a wheat-centric view ...................................................................................................................................................... 24 Microbial Genomics ........................................................................................................................... 25 (O7/P27) A novel species of human nasopharyngeal bacteria, distantly related to the avian pathogen Ornithobacterium rhinotracheale ...................................................................................... 25 (O8/P29) The population genetics of the ash dieback invasion of Europe highlights huge adaptive potential of the causal fungus, Hymenoscyphus fraxineus .............................................. 26 Evolutionary Genomics ....................................................................................................................... 27 (O9) A reference-free whole-genome alignment of hundreds of mammalian genomes ................ 27 (O10) The 200 Mammals Genome Project: Understanding Evolutionary Conservation at Single Base Resolution ....................................................................................................................... 28 (O11) Whole genome duplication and the evolution of salmonid fish: the state-of the art ............ 29 (O12/P68) The evolution of social chromosomes in fire ants ......................................................... 30 Clinical and Translational Genomics .................................................................................................. 31 (O13) Nucleosome positioning as a cell memory in cancer transitions .......................................... 31 (O14) Good or bad sequencing data? Setting a benchmark for the quality of diagnostic NGS in the lab ...................................................................................................................................... 32 Agricultural Genomics ........................................................................................................................ 33 (O15/P38) Downregulation of immune genes in quail in response to H5N1 infection .................. 33 ii (O16) Pan-genome assembly of population haplotypes provides a comprehensive solution to common obstacles in modern breeding ......................................................................................
Load more

Recommended publications
  • Ensembl Genomes: Extending Ensembl Across the Taxonomic Space P
    Published online 1 November 2009 Nucleic Acids Research, 2010, Vol. 38, Database issue D563–D569 doi:10.1093/nar/gkp871 Ensembl Genomes: Extending Ensembl across the taxonomic space P. J. Kersey*, D. Lawson, E. Birney, P. S. Derwent, M. Haimel, J. Herrero, S. Keenan, A. Kerhornou, G. Koscielny, A. Ka¨ ha¨ ri, R. J. Kinsella, E. Kulesha, U. Maheswari, K. Megy, M. Nuhn, G. Proctor, D. Staines, F. Valentin, A. J. Vilella and A. Yates EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK Received August 14, 2009; Revised September 28, 2009; Accepted September 29, 2009 ABSTRACT nucleotide archives; numerous other genomes exist in states of partial assembly and annotation; thousands of Ensembl Genomes (http://www.ensemblgenomes viral genomes sequences have also been generated. .org) is a new portal offering integrated access to Moreover, the increasing use of high-throughput genome-scale data from non-vertebrate species sequencing technologies is rapidly reducing the cost of of scientific interest, developed using the Ensembl genome sequencing, leading to an accelerating rate of genome annotation and visualisation platform. data production. This not only makes it likely that in Ensembl Genomes consists of five sub-portals (for the near future, the genomes of all species of scientific bacteria, protists, fungi, plants and invertebrate interest will be sequenced; but also the genomes of many metazoa) designed to complement the availability individuals, with the possibility of providing accurate and of vertebrate genomes in Ensembl. Many of the sophisticated annotation through the similarly low-cost databases supporting the portal have been built in application of functional assays.
    [Show full text]
  • The ELIXIR Core Data Resources: ​Fundamental Infrastructure for The
    Supplementary Data: The ELIXIR Core Data Resources: fundamental infrastructure ​ for the life sciences The “Supporting Material” referred to within this Supplementary Data can be found in the Supporting.Material.CDR.infrastructure file, DOI: 10.5281/zenodo.2625247 (https://zenodo.org/record/2625247). ​ ​ Figure 1. Scale of the Core Data Resources Table S1. Data from which Figure 1 is derived: Year 2013 2014 2015 2016 2017 Data entries 765881651 997794559 1726529931 1853429002 2715599247 Monthly user/IP addresses 1700660 2109586 2413724 2502617 2867265 FTEs 270 292.65 295.65 289.7 311.2 Figure 1 includes data from the following Core Data Resources: ArrayExpress, BRENDA, CATH, ChEBI, ChEMBL, EGA, ENA, Ensembl, Ensembl Genomes, EuropePMC, HPA, IntAct /MINT , InterPro, PDBe, PRIDE, SILVA, STRING, UniProt ● Note that Ensembl’s compute infrastructure physically relocated in 2016, so “Users/IP address” data are not available for that year. In this case, the 2015 numbers were rolled forward to 2016. ● Note that STRING makes only minor releases in 2014 and 2016, in that the interactions are re-computed, but the number of “Data entries” remains unchanged. The major releases that change the number of “Data entries” happened in 2013 and 2015. So, for “Data entries” , the number for 2013 was rolled forward to 2014, and the number for 2015 was rolled forward to 2016. The ELIXIR Core Data Resources: fundamental infrastructure for the life sciences ​ 1 Figure 2: Usage of Core Data Resources in research The following steps were taken: 1. API calls were run on open access full text articles in Europe PMC to identify articles that ​ ​ mention Core Data Resource by name or include specific data record accession numbers.
    [Show full text]
  • The LRRC8A:C Heteromeric Channel Is a Cgamp Transporter and the Dominant
    bioRxiv preprint doi: https://doi.org/10.1101/2020.02.13.948273; this version posted February 14, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The LRRC8A:C Heteromeric Channel Is a cGAMP Transporter and the Dominant cGAMP Importer in Human Vasculature Cells Lauren J. Lahey1,2, Xianlan Wen3, Rachel E. Mardjuki2,4, Volker Böhnert2,5, Christopher Ritchie2,5, Jacqueline A. Carozza2,4, Gaelen T. Hess2,6, Merritt Maduke3, Michael C. Bassik2,6, and Lingyin Li2,5,7,* 1Biophysics Program, 2Stanford ChEM-H, 3Department of Molecular and Cellular Physiology, 4Department of Chemistry, 5Department of Biochemistry, 6Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 USA. 7Lead Contact *Correspondence: [email protected] bioRxiv preprint doi: https://doi.org/10.1101/2020.02.13.948273; this version posted February 14, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. SUMMARY Extracellular 2'3'-cyclic-GMP-AMP (cGAMP) is an immunotransmitter secreted by cancer cells and taken up by host cells to activate the anti-cancer STING pathway. No cGAMP exporter has been identified, and SLC19A1, a recently identified cGAMP importer, does not account for the import actiVity in most cell types. Here, we identify the LRRC8A:C heteromeric channel, a volume-regulated anion channel (VRAC), as a cGAMP transporter. This channel mediates cGAMP import or export depending on the cGAMP chemical gradient. cGAMP influences anion influx through VRAC, indicating it is likely a direct substrate of the channel.
    [Show full text]
  • Selective Transport of Neurotransmitters and Modulators by Distinct Volume-Regulated LRRC8 Anion Channels Darius Lutter1,2,3, Florian Ullrich1,2, Jennifer C
    © 2017. Published by The Company of Biologists Ltd | Journal of Cell Science (2017) 130, 1122-1133 doi:10.1242/jcs.196253 RESEARCH ARTICLE Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels Darius Lutter1,2,3, Florian Ullrich1,2, Jennifer C. Lueck1,2,3, Stefan Kempa2 and Thomas J. Jentsch1,2,4,* ABSTRACT volume regulation (Jentsch, 2016; Nilius et al., 1997; Pedersen In response to swelling, mammalian cells release chloride and et al., 2016). This plasma membrane channel, which appears to be organic osmolytes through volume-regulated anion channels expressed in all cells, is normally closed but can be activated by cell swelling or other cellular signaling cascades. In most cells, VRAC (VRACs). VRACs are heteromers of LRRC8A and other LRRC8 − isoforms (LRRC8B to LRRC8E), which are co-expressed in HEK293 opening leads to an efflux of Cl , which, together with an efflux of + + and most other cells. The spectrum of VRAC substrates and its K through independent K channels, lowers the intracellular dependence on particular LRRC8 isoforms remains largely unknown. osmolarity and, by secondarily driving water efflux, results in We show that, besides the osmolytes taurine and myo-inositol, regulatory volume decrease. Cell swelling also stimulates an efflux ‘ ’ myo LRRC8 channels transport the neurotransmitters glutamate, of organic osmolytes such as -inositol, taurine and glutamate. aspartate and γ-aminobutyric acid (GABA) and the co-activator It was controversial whether this release occurs through VRAC or D-serine. HEK293 cells engineered to express defined subsets of through a distinct channel named VSOAC (for volume-sensitive LRRC8 isoforms were used to elucidate the subunit-dependence organic osmolyte/anion channel) (Jackson and Strange, 1993; of transport.
    [Show full text]
  • Vracs Swallow Platinum Drugs
    News & Views VRACs swallow platinum drugs Thomas Voets, Bernd Nilius & Rudi Vennekens Platinum-based drugs such as cisplatin react covalently with the N7 nitrogen in essential structural component of VRACs and carboplatin are on the WHO model list guanines (Galluzzi et al, 2012). This causes (Qiu et al, 2014; Voss et al, 2014). LRRC8 of essential medicines, as highly effective distortions in the DNA, which can provoke proteins form a small family of integral chemotherapeutic drugs for the treatment cell cycle arrest and ultimately programmed membrane proteins with four transmem- of various solid tumors. These drugs react cell death (Kelland, 2007; Galluzzi et al, brane helices and include five homologues with purine residues in DNA, thereby caus- 2012). However, before cisplatin and related (LRRC8A-E) in mammals and most other ing DNA damage, inhibition of cell division, drugs can exert their antiproliferative effects, chordates (Abascal & Zardoya, 2012). and eventually cell death. However, the they first need to be taken up by the targeted Current evidence indicates that functional mechanisms whereby platinum-based cells (Galluzzi et al, 2012). Cisplatin and VRAC channels are heteromultimers that drugs enter cancer cells remained poorly carboplatin are relatively polar, compared to contain the obligatory LRRC8A subunit understood. In this issue, Planells-Cases other classes of small-molecule (anticancer) supplemented with at least one of the other et al (2015) provide evidence that cells drugs. Consequently, their passive diffusion four isoforms (Voss et al, 2014). Based on take up cisplatin and carboplatin via through the plasma membrane is slow, and limited homology with pannexins, a hexam- volume-regulated anion channels (VRACs), other transport pathways, including trans- eric architecture has been proposed, but this more specifically VRACs composed of porters and channels, have been postulated.
    [Show full text]
  • The LRRC8A:C Heteromeric Channel Is a Cgamp Transporter and the Dominant Cgamp Importer in Human Vasculature Cells
    bioRxiv preprint doi: https://doi.org/10.1101/2020.02.13.948273; this version posted March 27, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The LRRC8A:C Heteromeric Channel Is a cGAMP Transporter and the Dominant cGAMP Importer in Human Vasculature Cells Lauren J. Lahey1,2, Xianlan Wen3, Rachel E. Mardjuki2,4, Volker Böhnert2,5, Gaelen T. Hess2,6, Christopher Ritchie2,5, Jacqueline A. Carozza2,4, Merritt Maduke3, Michael C. Bassik2,6, and Lingyin Li2,5,7,* 1Biophysics Program, 2Stanford ChEM-H, 3Department of Molecular and Cellular Physiology, 4Department of Chemistry, 5Department of Biochemistry, 6Department of Genetics, Stanford University, School of Medicine, Stanford, CA 94305 USA. 7Lead Contact *Correspondence: [email protected] bioRxiv preprint doi: https://doi.org/10.1101/2020.02.13.948273; this version posted March 27, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. SUMMARY Extracellular 2'3'-cyclic-GMP-AMP (cGAMP) is an immunotransmitter secreted by cancer cells and taken up by host cells to activate the anti-cancer STING pathway. No cGAMP exporter has been identified, and SLC19A1, a recently identified cGAMP importer, does not account for the import actiVity in most cell types. Here, we identify the LRRC8A:C heteromeric channel, a volume-regulated anion channel (VRAC), as a cGAMP transporter. This channel mediates cGAMP import or export depending on the cGAMP chemical gradient, and channel activation or inhibition modulates cGAMP transport.
    [Show full text]
  • Cabinet Agenda
    Cabinet Agenda Members of the Cabinet: Cllr J Fuller (Chairman) Leader, External Affairs and Policy Cllr K Mason Billig (Vice Chairman) Governance and Efficiency Cllr Y Bendle Better Lives Cllr M Edney Clean and Safe Environment Cllr L Neal Stronger Economy Cllr A Thomas Customer Focus Cllr J Worley Finance and Resources Date & Time: Monday 19 April 2021 9.00 am Place: To be hosted remotely at: South Norfolk House, Cygnet Court, Long Stratton, Norwich, NR15 2XE Contact: Claire White tel (01508) 533669 Email: [email protected] Website: www.south-norfolk.gov.uk PUBLIC ATTENDANCE: This meeting will be live streamed for public viewing via the following link: https://www.youtube.com/channel/UCZciRgwo84-iPyRImsTCIng If a member of the public would like to attend to speak on an agenda item, please email your request to [email protected], no later than 5.00pm on Thursday 15 April 2021. Large print version can be made available If you have any special requirements in order to attend this meeting, please let us know in advance. 1 AGENDA 1. To report apologies for absence 2. Any items of business which the Chairman decides should be considered as a matter of urgency pursuant to section 100B(4)(b) of the Local Government Act, 1972. Urgent business may only be taken if, “by reason of special circumstances” (which will be recorded in the minutes), the Chairman of the meeting is of the opinion that the item should be considered as a matter of urgency 3. To receive Declarations of interest from Members (please see guidance – page 4) 4.
    [Show full text]
  • Exploiting High Throughput DNA Sequencing Data for Genomic Analysis
    Exploiting high throughput DNA sequencing data for genomic analysis Markus Hsi-Yang Fritz Darwin College A dissertation submitted to the University of Cambridge for the degree of Doctor of Philosophy 14th October 2011 Markus Hsi-Yang Fritz EMBL-European Bioinformatics Institute Wellcome Trust Genome Campus Hinxton, Cambridge, CB10 1SD United Kingdom email: [email protected] This dissertation is the result of my own work and includes nothing which is the outcome of work done in collaboration except where specifically indicated in the text. No part of this work has been submitted or is currently being submitted for any other qualification. This document does not exceed the word limit of 60,000 words1 as defined by the Biology Degree Committee. Markus Hsi-Yang Fritz 14th October 2011 1 excluding bibliography, figures, appendices etc. To an exceptional scientist — my Dad. Exploiting high throughput DNA sequencing data for genomic analysis Summary Markus Hsi-Yang Fritz Darwin College The last few years have witnessed a drastic increase in genomic data. This has been facilitated by the shift away from the Sanger sequencing tech- nique to an array of high-throughput methods — so-called next-generation sequencing technologies. This enormous growth of available DNA data has been a tremendous boon to large-scale genomics studies and has rapidly advanced fields such as environmental genomics, ancient DNA research, population genomics and disease association. On the other hand, however, researchers and sequence archives are now facing an enormous data deluge. Critically, the rate of sequencing data accumulation is now outstripping advances in hard drive capacity, network bandwidth and processing power.
    [Show full text]
  • Research Focuses on the Gen- Maureen R
    This Month Surveying resident physician exposure to COVID-19 2 Alternative mechanisms underlying acute graft- versus-host disease 4 Targeting melanocortin signaling alleviates cachexia 5 Intrathecal gene therapy improves neuromuscular deterioration in canine model 6 September 2020 JCI This Month is a summary of the most recent articles in The Journal of Clinical Investigation and JCI Insight jci.org/this-month Placental infection by SARS–CoV-2 p. 2 Scan for the digital version of JCI This Month. Journal of Clinical Investigation Consulting Editors Soman N. Abraham Richard T. D'Aquila Katherine A. High Terri Laufer David J. Pinsky M. Celeste Simon John S. Adams Alan Daugherty Helen H. Hobbs Mitchell A. Lazar Edward Plow Mihaela Skobe Qais Al-Awqati Sudhansu Dey Ronald Hoffman Brendan Lee Catherine Postic Donald Small Kari Alitalo Anna Mae Diehl V. Michael Holers William M.F. Lee Alice S. Prince Lois Smith Dario C. Altieri Harry C. Dietz III Steven Holland Rudolph L. Leibel Louis J. Ptáček Akrit Sodhi Masayuki Amagai Gianpietro Dotti David Holtzman Wayne I. Lencer Luigi Puglielli Weihong Song Brian H. Annex Michael Dustin Michael J. Holtzman Jon D. Levine Pere Puigserver Ashley L. St. John M. Amin Arnaout Connie J. Eaves Lawrence B. Holzman Ross L. Levine Bali Pulendran Jonathan Stamler Alan Attie Dominique Eladari Tamas L. Horvath Klaus Ley Ellen Puré Colin L. Stewart Jane E. Aubin Joel K. Elmquist Gokhan S. Hotamisligil Rodger A. Liddle Susan E. Quaggin Doris Stoffers Michael F. Beers Stephen G. Emerson Steven R. Houser Richard Locksley Marlene Rabinovitch Warren Strober Vann Bennett Jonathan A.
    [Show full text]
  • Annual Scientific Report 2013 on the Cover Structure 3Fof in the Protein Data Bank, Determined by Laponogov, I
    EMBL-European Bioinformatics Institute Annual Scientific Report 2013 On the cover Structure 3fof in the Protein Data Bank, determined by Laponogov, I. et al. (2009) Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases. Nature Structural & Molecular Biology 16, 667-669. © 2014 European Molecular Biology Laboratory This publication was produced by the External Relations team at the European Bioinformatics Institute (EMBL-EBI) A digital version of the brochure can be found at www.ebi.ac.uk/about/brochures For more information about EMBL-EBI please contact: [email protected] Contents Introduction & overview 3 Services 8 Genes, genomes and variation 8 Molecular atlas 12 Proteins and protein families 14 Molecular and cellular structures 18 Chemical biology 20 Molecular systems 22 Cross-domain tools and resources 24 Research 26 Support 32 ELIXIR 36 Facts and figures 38 Funding & resource allocation 38 Growth of core resources 40 Collaborations 42 Our staff in 2013 44 Scientific advisory committees 46 Major database collaborations 50 Publications 52 Organisation of EMBL-EBI leadership 61 2013 EMBL-EBI Annual Scientific Report 1 Foreword Welcome to EMBL-EBI’s 2013 Annual Scientific Report. Here we look back on our major achievements during the year, reflecting on the delivery of our world-class services, research, training, industry collaboration and European coordination of life-science data. The past year has been one full of exciting changes, both scientifically and organisationally. We unveiled a new website that helps users explore our resources more seamlessly, saw the publication of ground-breaking work in data storage and synthetic biology, joined the global alliance for global health, built important new relationships with our partners in industry and celebrated the launch of ELIXIR.
    [Show full text]
  • Norfolk Strategic Planning Framework
    Norfolk Strategic Planning Framework Shared Spatial Objectives for a Growing County and Statement of Common Ground May 2021 Signatories • Breckland District Council • Broadland District Council • Broads Authority • Great Yarmouth Borough Council • Borough Council of King’s Lynn and West Norfolk • North Norfolk District Council • Norwich City Council • South Norfolk Council • Norfolk County Council • Natural England • Environment Agency • Anglian Water • Marine Management Organisation • New Anglia Local Enterprise Partnership • Active Norfolk • Water Resources East Acknowledgements The authors would like to thank the following organisations for their support in the production of this document: • Breckland District Council • Broadland District Council • Broads Authority • Great Yarmouth Borough Council • Borough Council of King’s Lynn and West Norfolk • North Norfolk District Council • Norwich City Council • South Norfolk Council • Norfolk County Council • Suffolk County Council • Babergh & Mid Suffolk District Councils • East Suffolk Council • West Suffolk Council • Fenland District Council • East Cambridgeshire District Council • South Holland District Council • Natural England • Environment Agency • Wild Anglia • Anglian Water • New Anglia Local Enterprise Partnership • UK Power Networks • Cambridgeshire and Peterborough Combined Authority • Norfolk and Waveney CCG • NHS Sustainability and Transformation Partnership Estates for Norfolk and Waveney • Mobile UK Norfolk Strategic Planning Framework Page 2 Contents SIGNATORIES ........................................................................................................................
    [Show full text]
  • Strategic Plan 2011-2016
    Strategic Plan 2011-2016 Wellcome Trust Sanger Institute Strategic Plan 2011-2016 Mission The Wellcome Trust Sanger Institute uses genome sequences to advance understanding of the biology of humans and pathogens in order to improve human health. -i- Wellcome Trust Sanger Institute Strategic Plan 2011-2016 - ii - Wellcome Trust Sanger Institute Strategic Plan 2011-2016 CONTENTS Foreword ....................................................................................................................................1 Overview .....................................................................................................................................2 1. History and philosophy ............................................................................................................ 5 2. Organisation of the science ..................................................................................................... 5 3. Developments in the scientific portfolio ................................................................................... 7 4. Summary of the Scientific Programmes 2011 – 2016 .............................................................. 8 4.1 Cancer Genetics and Genomics ................................................................................ 8 4.2 Human Genetics ...................................................................................................... 10 4.3 Pathogen Variation .................................................................................................. 13 4.4 Malaria
    [Show full text]