Genome 10K c ABSTRACTS GENOME 10K & GENOME SCIENCE 29 AUG - 1 SEPT 2017 NORWICH RESEARCH PARK, NORWICH, UK Genome 10K c 48 KEYNOTE SPEAKERS ............................................................................................................................... 1 Dr Adam Phillippy: Towards the gapless assembly of complete vertebrate genomes .................... 1 Prof Kathy Belov: Saving the Tasmanian devil from extinction ......................................................... 1 Prof Peter Holland: Homeobox genes and animal evolution: from duplication to divergence ........ 2 Dr Hilary Burton: Genomics in healthcare: the challenges of complexity .......................................... 2 INVITED SPEAKERS ................................................................................................................................. 3 Vertebrate Genomics ........................................................................................................................... 3 Alex Cagan: Comparative genomics of animal domestication .......................................................... 3 Plant Genomics .................................................................................................................................... 4 Ksenia Krasileva: Evolution of plant Immune receptors ..................................................................... 4 Andrea Harper: Using Associative Transcriptomics to predict tolerance to ash dieback disease in European ash trees ............................................................................................................. 4 Microbial Genomics ............................................................................................................................. 5 John Lees: Scalable pan-genome-wide association studies in bacteria ........................................... 5 Gemma Langridge: Contaminant or infective agent? Re-classifying the staphylococci for modern medicine .................................................................................................................................. 6 Evolutionary Genomics ......................................................................................................................... 7 Emma Teeling: Growing old yet staying young: A genomic perspective on bats’ extraordinary longevity ......................................................................................................................... 7 Clinical and Translational Genomics .................................................................................................... 8 Joris Veltman: De novo mutations in genetic disease ....................................................................... 8 Matthew Hurles: Deciphering Developmental Disorders .................................................................... 8 Agricultural Genomics .......................................................................................................................... 9 Alan Archibald: Precision engineering for PRRSV resistance in pigs ................................................ 9 Nicola Patron: Engineering Plant Genomes for Farming and Pharming ........................................... 9 Conservation Genomics ..................................................................................................................... 10 Beth Shapiro: The genomic consequences of inbreeding in mountain lions, Puma concolor ....... 10 Developmental Biology ....................................................................................................................... 11 Kristin Tessmar-Raible: Genomic and transcriptomic approaches for the study of daily, monthly and seasonal timing ............................................................................................................. 11 Andrea Münsterberg: Cellular dynamics and lineage specification in developing somites ........... 12 Microbial Communities ...................................................................................................................... 13 Mads Albertsen: Towards a fully populated tree of life .................................................................... 13 Lindsay Hall: Early life microbial communities ................................................................................. 13 Sequencing Technology and Developments ....................................................................................... 14 Aaron McKenna: Information and storage recovery using the diversity of second- generation sequencing technologies ................................................................................................. 14 i Genome Informatics........................................................................................................................... 15 Doreen Ware: TBC ............................................................................................................................... 15 Population Genomics ......................................................................................................................... 16 Richard Durbin: Whole genome sequence studies of the Lake Malawi cichlid adaptive radiation ............................................................................................................................................... 16 Single Cell .......................................................................................................................................... 17 Muzlifah Haniffa: Deconstructing the immune system using single cell technologies .................. 17 Tamir Chandra: Understanding cellular heterogeneity in cellular senescence and ageing through single cell transcriptomics ................................................................................................... 17 Stephen Sansom: Transcript structures in the thymus: improvised or rehearsed? ........................ 18 ORAL PRESENTATIONS ......................................................................................................................... 19 Vertebrate Genomics ......................................................................................................................... 19 (O1/P61) Comparative whole-genome study of eleven Felidae species from six lineages ........... 19 (O2/P52) A Cross-Species Bioinformatics and FISH approach to physical mapping of Mammalian Genomes ........................................................................................................................ 20 (O3/P65) Expansion of gene families and signatures of selection in the Australian marsupials ........................................................................................................................................... 21 (O4) The tuatara genome project— Unlocking the genome of a living fossil .................................. 22 Plant Genomics .................................................................................................................................. 23 (O5/P19) The evolution of photosynthetic efficiency ....................................................................... 23 (O6/P24) Designing multi-genome graphs for crop genomics and genetics: a wheat-centric view ...................................................................................................................................................... 24 Microbial Genomics ........................................................................................................................... 25 (O7/P27) A novel species of human nasopharyngeal bacteria, distantly related to the avian pathogen Ornithobacterium rhinotracheale ...................................................................................... 25 (O8/P29) The population genetics of the ash dieback invasion of Europe highlights huge adaptive potential of the causal fungus, Hymenoscyphus fraxineus .............................................. 26 Evolutionary Genomics ....................................................................................................................... 27 (O9) A reference-free whole-genome alignment of hundreds of mammalian genomes ................ 27 (O10) The 200 Mammals Genome Project: Understanding Evolutionary Conservation at Single Base Resolution ....................................................................................................................... 28 (O11) Whole genome duplication and the evolution of salmonid fish: the state-of the art ............ 29 (O12/P68) The evolution of social chromosomes in fire ants ......................................................... 30 Clinical and Translational Genomics .................................................................................................. 31 (O13) Nucleosome positioning as a cell memory in cancer transitions .......................................... 31 (O14) Good or bad sequencing data? Setting a benchmark for the quality of diagnostic NGS in the lab ...................................................................................................................................... 32 Agricultural Genomics ........................................................................................................................ 33 (O15/P38) Downregulation of immune genes in quail in response to H5N1 infection .................. 33 ii (O16) Pan-genome assembly of population haplotypes provides a comprehensive solution to common obstacles in modern breeding ......................................................................................