NSF-NSEC for Integrated Nanopatterning and Detection Technologies (NSEC Grant Number EEC – 0647560) (PI), Michael Bedzyk, Vinayak Dravid, Horacio Espinosa, Franz Geiger, Mark Hersam, Joseph Hupp, SonBinh Nguyen, Monica Olvera de la Cruz, George Schatz, Richard Van Duyne, William Klein, Chang Liu, Milan Mrksich, Steve Sligar, Teri Odom, Steve Wolinsky, Laurie Zoloth, Mercouri Kanatzidis, Jiaxing Huang, C. Shad Thaxton , University of Chicago, University of at Urbana-Champaign SRG 1: Nanopatterning Education and Outreach

Research Experience for Undergraduates Research Experience for Teachers Partnership with the Museum of Science . 255 REU participants . Program includes hands-on research and and Industry, Chicago curriculum development for their classrooms . 67% of participants women and underrepresented . Resulting in 2,400 square ft permanent exhibit minorities . 88 pre-college teachers have participated to-date on . Opening Spring 2013 . Hands-on research plus professional development . > 11,000 pre-college students impacted to-date 2 nm activities . Potential to reach over 2 million visitors per year – Technical writing course – Public Speaking workshop DiscoverNano Website Dip-Pen Nanolithography Feedback Controlled Lithography Heteromolecular – Tour of Argonne National Laboratory (www.discovernano.northwestern.edu) – Final symposium and written paper . ~1,000,000 visitors a year 10 million Pen Array Intermolecular spacing with atomic precision Nanostructures – Over 100 published papers . Includes: Knowledge Transfer (to-date) – Introduction to nanotechnology – Historical timeline . > 850 publications – Nano Art gallery . 151 invention disclosures and 75 patent filings – Curriculum projects – Meet the Researchers section . 1,607 domestic and international seminars & colloquia Nanotechnology Town Hall Meetings . 104 Frontiers in Nanotechnology Seminars Nanoscape: The Journal of Undergraduate . Introduces nanotechnology to the public Research in Nanoscience . 8 International Institute for Nanotechnology Symposiums . Addresses societal/ethical concerns . 103 articles published to date . 17 start-up companies launched through Small Business . 7 meetings held, > 600 attendees to date . Undergraduate authors from institutions across the Evaluation & Entrepreneur’s (SBEE) Program with over country $600M in VC invested Nanoscience Pre-college Module . Inquiry-based, links to real-world applications, . 20 companies enlisted in Nanotechnology Corporate . Volume VIII released Summer 2011 extensively field-tested Partners (NCP) program . On-line and print version . Includes student & teacher manuals Polymer Pen Lithography 2-D Active Probe Arrays Parallel Inking Wells . 70 Industrial partnerships . Print version mailed to >1,000 college and university . Being disseminated world-wide by NCLT departments and libraries . 55 International partnerships SRG 2: Signal Transduction & Receptor Design SRG 3:Integrated Biodetection Chip MOSFET-embedded Improved bio-barcode assay Surface immobilized bio-barcode assay

Flow microcantilever development

Detector

Alkanethiolate 250 nm MS Alkyldisulfide

Aperture Lamp Spectrometer Flow cell m/z Integrated chip-based detection system New Receptor Chemistries Detection Strategies Enabled by NanoMaterials Protein biomarker identification

Drug Binding to Membrane Proteins Measuring Telomerase Activity Profiling HDAC Activity Ac Ac-GXK ZGC-NH2 X Position D N E Q K R H S T M W F Y V I L A G P D N E Q K R H S Integration of novel receptors with nanomechanical detection platform T M

Z Position Z W F Y V I L A G P The authors thank the 0 1 National Science Foundation for support of this work.