Friedrich Krukenberg of Krukenberg's Tumor
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Scientific Framework for Pancreatic Ductal Adenocarcinoma (PDAC)
Scientific Framework for Pancreatic Ductal Adenocarcinoma (PDAC) National Cancer Institute February 2014 1 Table of Contents Executive Summary 3 Introduction 4 Background 4 Summary of the Literature and Recent Advances 5 NCI’s Current Research Framework for PDAC 8 Evaluation and Expansion of the Scientific Framework for PDAC Research 11 Plans for Implementation of Recommended Initiatives 13 Oversight and Benchmarks for Progress 18 Conclusion 18 Links and References 20 Addenda 25 Figure 1: Trends in NCI Funding for Pancreatic Cancer, FY2000-FY2012 Figure 2: NCI PDAC Funding Mechanisms in FY2012 Figure 3: Number of Investigators with at Least One PDAC Relevant R01 Grant FY2000-FY2012 Figure 4: Number of NCI Grants for PDAC Research in FY 2012 Awarded to Established Investigators, New Investigators, and Early Stage Investigators Table 1: NCI Trainees in Pancreatic Cancer Research Appendices Appendix 1: Report from the Pancreatic Cancer: Scanning the Horizon for Focused Invervention Workshop Appendix 2: NCI Investigators and Projects in PDAC Research 2 Scientific Framework for Pancreatic Ductal Carcinoma Executive Summary Significant scientific progress has been made in the last decade in understanding the biology and natural history of pancreatic ductal adenocarcinoma (PDAC); major clinical advances, however, have not occurred. Although PDAC shares some of the characteristics of other solid malignancies, such as mutations affecting common signaling pathways, tumor heterogeneity, development of invasive malignancy from precursor lesions, -
Differential Diagnosis of Ovarian Mucinous Tumours Sigurd F
Differential Diagnosis of Ovarian Mucinous Tumours Sigurd F. Lax LKH Graz II Academic Teaching Hospital of the Medical University Graz Pathology Mucinous tumours of the ovary • Primary ➢Seromucinous tumours ➢Mucinous tumours ➢Benign, borderline, malignant • Secondary (metastatic) ➢Metastases (from gastrointestinal tract) • Metastases can mimic primary ovarian tumour Mucinous tumours: General • 2nd largest group after serous tumours • Gastro-intestinal differentiation (goblet cells) • Endocervical type> seromucinous tumours • Majority is unilateral, particularly cystadenomas and borderline tumours • Bilaterality: rule out metastatic origin • Adenoma>carcinoma sequence reflected by a mixture of benign, atypical proliferating and malignant areas within the same tumour Sero-mucinous ovarian tumours • Previous endocervical type of mucinous tumor • Mixture of at least 2 cell types: mostly serous • Association with endometriosis; multifocality • Similarity with endometrioid and serous tumours, also immunophenotype • CK7, ER, WT1 positive; CK20, cdx2 negativ • Most cystadenoma and borderline tumours • Carcinomas rare and difficult to diagnose Shappel et al., 2002; Dube et al., 2005; Vang et al. 2006 Seromucinous Borderline Tumour ER WT1 Seromucinous carcinoma being discontinued? • Poor reproducibility: Low to modest agreement from 39% to 56% for 4 observers • Immunophenotype not unique, overlapped predominantly with endometrioid and to a lesser extent with mucinous and low-grade serous carcinoma • Molecular features overlap mostly with endometrioid -
A Case of Krukenberg Tumor Metastasized from Colon Cancer In
A case of Krukenberg tumor metastasized from colon cancer in pregnancy Oztas E, Ozler S, Ersoy AO, Turker M, Zengın NI, Caglar AT, Danisman N Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey Objective Krukenberg tumor refers to gastrointestinal cancer metastatic to the ovaries and has an extremely poor prognosis, with a 5-year survival rate ranging from 12% to 23. 4%. Gastric cancer has been reported as the most frequent primary source of Krukenberg tumor; however, tumors of the colon, appendix, breast, lung, and pancreas have also been reported to metastasize into the ovaries. Krukenberg tumors are usually seen in the fifth decade of life, with an average age of 45 years and cases diagnosed during pregnancy are thus extremely rare. Methods We report a case of a Krukenberg tumor secondary to colon carcinoma in a pregnant woman with acute pelvic pain. The prenatal diagnosis was made at 17 weeks’ gestation. Results A 27-year-old, primigravida with a semisolid right adnexial mass was presented with acute pelvic pain at 17 weeks’ gestation. Ultrasonography revealed a semisolid right adnexial mass of 140×130 mm and ascites, as well as a single live fetus compatible for gestational age. The abdomen was tense, tender and distended so exploratory laparotomy was performed with the suspicion of ovarian torsion. During the operation, ascites, enlarged right ovary with the presence of a necrotic tumor measuring 160×140 mm causing ovarian torsion and omental metastasis were seen. Unilateral oophorectomy and omentectomy were then performed. Histopathological examination of the specimen revealed adenocarcinoma metastasis to the ovary and the omentum probably originating from a primary gastrointestinal carcinoma (Figure-1). -
The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Inherited Polyposis Syndromes Daniel Herzig, M.D
CLINICAL PRACTICE GUIDELINES The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Inherited Polyposis Syndromes Daniel Herzig, M.D. • Karin Hardimann, M.D. • Martin Weiser, M.D. • Nancy Yu, M.D. Ian Paquette, M.D. • Daniel L. Feingold, M.D. • Scott R. Steele, M.D. Prepared by the Clinical Practice Guidelines Committee of The American Society of Colon and Rectal Surgeons he American Society of Colon and Rectal Surgeons METHODOLOGY (ASCRS) is dedicated to ensuring high-quality pa- tient care by advancing the science, prevention, and These guidelines are built on the last set of the ASCRS T Practice Parameters for the Identification and Testing of management of disorders and diseases of the colon, rectum, Patients at Risk for Dominantly Inherited Colorectal Can- and anus. The Clinical Practice Guidelines Committee is 1 composed of society members who are chosen because they cer published in 2003. An organized search of MEDLINE have demonstrated expertise in the specialty of colon and (1946 to December week 1, 2016) was performed from rectal surgery. This committee was created to lead interna- 1946 through week 4 of September 2016 (Fig. 1). Subject tional efforts in defining quality care for conditions related headings for “adenomatous polyposis coli” (4203 results) to the colon, rectum, and anus, in addition to the devel- and “intestinal polyposis” (445 results) were included, us- opment of Clinical Practice Guidelines based on the best ing focused search. The results were combined (4629 re- available evidence. These guidelines are inclusive and not sults) and limited to English language (3981 results), then prescriptive. -
Human Anatomy As Related to Tumor Formation Book Four
SEER Program Self Instructional Manual for Cancer Registrars Human Anatomy as Related to Tumor Formation Book Four Second Edition U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutesof Health SEER PROGRAM SELF-INSTRUCTIONAL MANUAL FOR CANCER REGISTRARS Book 4 - Human Anatomy as Related to Tumor Formation Second Edition Prepared by: SEER Program Cancer Statistics Branch National Cancer Institute Editor in Chief: Evelyn M. Shambaugh, M.A., CTR Cancer Statistics Branch National Cancer Institute Assisted by Self-Instructional Manual Committee: Dr. Robert F. Ryan, Emeritus Professor of Surgery Tulane University School of Medicine New Orleans, Louisiana Mildred A. Weiss Los Angeles, California Mary A. Kruse Bethesda, Maryland Jean Cicero, ART, CTR Health Data Systems Professional Services Riverdale, Maryland Pat Kenny Medical Illustrator for Division of Research Services National Institutes of Health CONTENTS BOOK 4: HUMAN ANATOMY AS RELATED TO TUMOR FORMATION Page Section A--Objectives and Content of Book 4 ............................... 1 Section B--Terms Used to Indicate Body Location and Position .................. 5 Section C--The Integumentary System ..................................... 19 Section D--The Lymphatic System ....................................... 51 Section E--The Cardiovascular System ..................................... 97 Section F--The Respiratory System ....................................... 129 Section G--The Digestive System ......................................... 163 Section -
Familial Adenomatous Polyposis Polymnia Galiatsatos, M.D., F.R.C.P.(C),1 and William D
American Journal of Gastroenterology ISSN 0002-9270 C 2006 by Am. Coll. of Gastroenterology doi: 10.1111/j.1572-0241.2006.00375.x Published by Blackwell Publishing CME Familial Adenomatous Polyposis Polymnia Galiatsatos, M.D., F.R.C.P.(C),1 and William D. Foulkes, M.B., Ph.D.2 1Division of Gastroenterology, Department of Medicine, The Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada, and 2Program in Cancer Genetics, Departments of Oncology and Human Genetics, McGill University, Montreal, Quebec, Canada Familial adenomatous polyposis (FAP) is an autosomal-dominant colorectal cancer syndrome, caused by a germline mutation in the adenomatous polyposis coli (APC) gene, on chromosome 5q21. It is characterized by hundreds of adenomatous colorectal polyps, with an almost inevitable progression to colorectal cancer at an average age of 35 to 40 yr. Associated features include upper gastrointestinal tract polyps, congenital hypertrophy of the retinal pigment epithelium, desmoid tumors, and other extracolonic malignancies. Gardner syndrome is more of a historical subdivision of FAP, characterized by osteomas, dental anomalies, epidermal cysts, and soft tissue tumors. Other specified variants include Turcot syndrome (associated with central nervous system malignancies) and hereditary desmoid disease. Several genotype–phenotype correlations have been observed. Attenuated FAP is a phenotypically distinct entity, presenting with fewer than 100 adenomas. Multiple colorectal adenomas can also be caused by mutations in the human MutY homologue (MYH) gene, in an autosomal recessive condition referred to as MYH associated polyposis (MAP). Endoscopic screening of FAP probands and relatives is advocated as early as the ages of 10–12 yr, with the objective of reducing the occurrence of colorectal cancer. -
Lung Equivalent Terms, Definitions, Charts, Tables and Illustrations C340-C349 (Excludes Lymphoma and Leukemia M9590-9989 and Kaposi Sarcoma M9140)
Lung Equivalent Terms, Definitions, Charts, Tables and Illustrations C340-C349 (Excludes lymphoma and leukemia M9590-9989 and Kaposi sarcoma M9140) Introduction Use these rules only for cases with primary lung cancer. Lung carcinomas may be broadly grouped into two categories, small cell and non-small cell carcinoma. Frequently a patient may have two or more tumors in one lung and may have one or more tumors in the contralateral lung. The physician may biopsy only one of the tumors. Code the case as a single primary (See Rule M1, Note 2) unless one of the tumors is proven to be a different histology. It is irrelevant whether the other tumors are identified as cancer, primary tumors, or metastases. Equivalent or Equal Terms • Low grade neuroendocrine carcinoma, carcinoid • Tumor, mass, lesion, neoplasm (for multiple primary and histology coding rules only) • Type, subtype, predominantly, with features of, major, or with ___differentiation Obsolete Terms for Small Cell Carcinoma (Terms that are no longer recognized) • Intermediate cell carcinoma (8044) • Mixed small cell/large cell carcinoma (8045) (Code is still used; however current accepted terminology is combined small cell carcinoma) • Oat cell carcinoma (8042) • Small cell anaplastic carcinoma (No ICD-O-3 code) • Undifferentiated small cell carcinoma (No ICD-O-3 code) Definitions Adenocarcinoma with mixed subtypes (8255): A mixture of two or more of the subtypes of adenocarcinoma such as acinar, papillary, bronchoalveolar, or solid with mucin formation. Adenosquamous carcinoma (8560): A single histology in a single tumor composed of both squamous cell carcinoma and adenocarcinoma. Bilateral lung cancer: This phrase simply means that there is at least one malignancy in the right lung and at least one malignancy in the left lung. -
Ovarian Carcinomas, Including Secondary Tumors: Diagnostically Challenging Areas
Modern Pathology (2005) 18, S99–S111 & 2005 USCAP, Inc All rights reserved 0893-3952/05 $30.00 www.modernpathology.org Ovarian carcinomas, including secondary tumors: diagnostically challenging areas Jaime Prat Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain The differential diagnosis of ovarian carcinomas, including secondary tumors, remains a challenging task. Mucinous carcinomas of the ovary are rare and can be easily confused with metastatic mucinous carcinomas that may present clinically as a primary ovarian tumor. Most of these originate in the gastrointestinal tract and pancreas. International Federation of Gynecology and Obstetrics (FIGO) stage is the single most important prognostic factor, and stage I carcinomas have an excellent prognosis; FIGO stage is largely related to the histologic features of the ovarian tumors. Infiltrative stromal invasion proved to be biologically more aggressive than expansile invasion. Metastatic colon cancer is frequent and often simulates ovarian endometrioid adenocarcinoma. Although immunostains for cytokeratins 7 and 20 can be helpful in the differential diagnosis, they should always be interpreted in the light of all clinical information. Occasionally, endometrioid carcinomas may exhibit a microglandular pattern simulating sex cord-stromal tumors. However, typical endometrioid glands, squamous differentiation, or an adenofibroma component are each present in 75% of these tumors whereas immunostains for calretinin and alpha-inhibin are negative. Endometrioid carcinoma of the ovary is associated in 15–20% of the cases with carcinoma of the endometrium. Most of these tumors have a favorable outcome and they most likely represent independent primary carcinomas arising as a result of a Mu¨ llerian field effect. -
Please Bring Your ~Rotocol, but Do Not Bring Slides Or Microscopes to T He Meeting, CALIFORNIA TUMOR TISSUE REGISTRY
CALIFORNIA TUMOR TISSUE REGISTRY FIFTY- SEVENTH SEMI-ANNUAL SLIDE S~IINAR ON TIJMORS OF THE F~IALE GENITAL TRACT MODERATOR: RlCl!AlUJ C, KEMPSON, M, D, ASSOCIATE PROFESSOR OF PATHOLOGY & CO-DIRECTOR OF SURGICAL PATHOLOGY STANFORD UNIVERSITY MEDICAL CEllTER STANFOliD, CALIFORNIA CHAl~lAN : ALBERT HIRST, M, D, PROFESSOR OF PATHOLOGY LOMA LINDA UNIVERSITY MEDICAL CENTER L~.A LINDA, CALIPORNIA SUNDAY, APRIL 21, 1974 9 : 00 A. M. - 5:30 P,M, REGISTRATION: 7:30 A. M. PASADENA HILTON HOTEL PASADENA, CALIFORNIA Please bring your ~rotocol, but do not bring slides or microscopes to t he meeting, CALIFORNIA TUMOR TISSUE REGISTRY ~lELDON K, BULLOCK, M, D, (EXECUTIVE DIRECTOR) ROGER TERRY, ~1. Ii, (CO-EXECUTIVE DIRECTOR) ~Irs, June Kinsman Mrs. Coral Angus Miss G, Wilma Cline Mrs, Helen Yoshiyama ~fr s. Cheryl Konno Miss Peggy Higgins Mrs. Hataie Nakamura SPONSORS: l~BER PATHOLOGISTS AMERICAN CANCER SOCIETY, CALIFORNIA DIVISION CALIFORNIA MEDICAL ASSOCIATION LAC-USC MEDICAL CENlllR REGIONAL STUDY GRaJPS: LOS ANGELES SAN F~ICISCO CEt;TRAL VALLEY OAKLAND WEST LOS ANGELES SOUTH BAY SANTA EARBARA SAN DIEGO INLAND (SAN BERNARDINO) OHIO SEATTLE ORANGE STOCKTON ARGENTINA SACRJIMENTO ILLINOIS We acknowledge with thanks the voluntary help given by JOHN TRAGERMAN, M. D., PATHOLOGIST, LAC-USC MEDICAL CENlllR VIVIAN GILDENHORN, ASSOCIATE PATHOLOGIST, I~TERCOMMUNITY HOSPITAL ROBERT M. SILTON, M. D,, ASSISTANT PATHOLOGIST, CITY OF HOPE tiEDICAL CENTER JOHN N, O'DON~LL, H. D,, RESIDENT IN PATHOLOGY, LAC-USC MEDICAL CEN!ER JOHN R. CMIG, H. D., RESIDENT IN PATHOLOGY, LAC-USC MEDICAL CENTER CHAPLES GOLDSMITH, M, D. , RESIDENT IN PATHOLOGY, LAC-USC ~IEDICAL CEUTER HAROLD AMSBAUGH, MEDICAL STUDENT, LAC-USC MEDICAL GgNTER N~IE-: E, G. -
List of Acceptable TCGA Tumor Types*
List of Acceptable TCGA Tumor Types* Acute Myeloid Leukemia Head and Neck Squamous ** Ovarian Carcinoma** Thyroid Papillary Carcinoma** Squamous Cell Carcinoma Serous Cystadenocarcinoma Papillary, Usual Type (Papillary, NOS) Bladder Urothelial Carcinoma Squamous Cell Carcinoma, Spindle Cell Variant Serous carcinoma Papillary, Follicular Variant (99% follicular patterned) Muscle invasive urothelial carcinoma (PT2 or above) Squamous Cell Carcinoma, Basaloid Type Serous adenocarcinoma Papillary, Tall cell Variant (50% tall cell features) Papillary Serous carcinoma Papillary, Other Breast Invasive Carcinoma Hepatocellular Carcinoma Papillary Serous cystoadenocarcinoma Infiltrating Ductal Carcinoma** Hepatocellular Carcinoma, NOS Serous Papillary carcinoma Rare Tumor Studies Infiltrating Lobular Carcinoma Fibrolamellar Hepatocellular Carcinoma Serous Papillary cystoadenocarcinoma Medullary Carcinoma Hepatocholangiocarcinoma (mixed) Serous Papillary adenocarcinoma Adrenocortcal Tumors*** Mucinous Carcinoma Adrenocortical carcinoma - Usual Type Metaplastic Carcinoma Kidney Adenocarcinoma Pancreatic Adenocarcinoma Adrenocortical carcinoma - Oncocytic Type Mixed (with Ductal) Histology*** Clear Cell Renal Cell Carcinoma** Adenocarcinoma, ductal type Adrenocortical carcinoma - Myxoid Type Other Papillary Renal Cell Carcinoma Colloid (mucinous non-cystic) Carcinoma Hepatoid Carcinoma Chromophobe Kidney*** Cervical Cancer Lower Grade Glioma** Medullary Carcinoma Cervical Squamous Cell Carcinoma Astrocytoma, Grade II Signet Ring Cell Carcinoma Mesothelioma -
Primary Ovarian Signet Ring Cell Carcinoma: a Rare Case Report
MOLECULAR AND CLINICAL ONCOLOGY 9: 211-214, 2018 Primary ovarian signet ring cell carcinoma: A rare case report JI HYE KIM1, HEE JEONG CHA1,2, KYU-RAE KIM2,3 and KYUNGBIN KIM1 1Department of Pathology, Ulsan University Hospital, Ulsan 44033; 2Division of Pathology, University of Ulsan, College of Medicine, Seoul 05505; 3Department of Pathology, Asan Medical Center, Seoul 05505, Republic of Korea Received April 18, 2018; Accepted June 12, 2018 DOI: 10.3892/mco.2018.1653 Abstract. Signet ring cell carcinoma (SRCC) of the ovary is and may be challenging. We herein report the case a patient most commonly metastatic from a primary lesion. Primary diagnosed with primary SRCC of the ovary. ovarian SRCC is rare, and the distinction between primary and metastatic SRCC of the ovary may be difficult. We Case report herein present a case of primary SRCC of the ovary in a 54-year-old woman presenting with a right ovarian mass A 54-year-old woman was admitted to the Ulsan University sized 20.5x16.5x11.5 cm. Total abdominal hysterectomy with Hospital (Ulsan, South Korea) with a palpable firm abdominal bilateral salpingo-oophorectomy, partial omentectomy and mass. The patient exhibited no major symptoms and had no incidental appendectomy were performed. Upon histological specific past history. The patient underwent an abdominal examination, mucinous carcinoma composed predominantly computed tomography (CT) scan, which revealed a ~20-cm of signet ring cells was observed in the right ovary. The multiseptated cystic and solid mass arising from the right results of immunohistochemical examination included diffuse ovary. The abdominal CT scan did not reveal any lesions in positivity for cytokeratin (CK)7 and CK20, but the tumor was the gastrointestinal tract. -
A Rare Cause of Painless Haematuria- Adenocarcinoma of Appendix
Ju ry [ rnal e ul rg d u e S C f h o i l r u a Journal of Surgery r n g r i u e o ] J ISSN: 1584-9341 [Jurnalul de Chirurgie] Case Report Open Access A Rare Cause of Painless Haematuria- Adenocarcinoma of Appendix Shantanu Kumar Sahu1*, Shikhar Agarwal2, Sanjay Agrawal3, Shailendra Raghuvanshi4, Nadia Shirazi5, Saurabh Agrawal1 and Uma Sharma1 1Department of General Surgery, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Uttarakhand, India 2Department of Urology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Uttarakhand, India 3Department of Anesthesia, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Uttarakhand, India 4Department of Radiodiagnosis, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Uttarakhand, India 5Department of Pathology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Uttarakhand, India Abstract Neoplasms of the appendix are rare, accounting for less than 0.5% of all gastrointestinal malignancies and found incidentally in approximately 1% of appendectomy specimen. Carcinoids are the most common appendicular tumors, accounting for approximately 66%, with cystadenocarcinoma accounting for 20% and adenocarcinoma accounting for 10%. Appendiceal adenocarcinomas fall into one of three separate histologic types. The most common mucinous type produces abundant mucin, the less common intestinal or colonic type closely mimics adenocarcinomas found in the colon, and the least common, signet ring cell adenocarcinoma, is quite virulent and associated with a poor prognosis. Adenocarcinoma of appendix is most frequently perforating tumour of gastrointestinal tract due to anatomical peculiarity of appendix which has an extremely thin subserosal and peritoneal coat and the thinnest muscle layer of the whole gastrointestinal tract.