Rabbit Anti-Human KCNAB2 Polyclonal Antibody (DPABH-15471) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Rabbit Anti-Human KCNAB2 Polyclonal antibody (DPABH-15471) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Immunogen KCNAB2 fusion protein, sequence: MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTFGG QITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETE RGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWS SMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKY DSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSV LLGASNADQLMENIGAIQVRVRGPAGQRAHPSPSPVQCILPGSSCVPGSVLGTQDAPVNHQSC APGELAFQQEQT (1-395 aa encoded by BC110351)

Isotype IgG

Source/Host Rabbit

Species Reactivity Human, Mouse, Rat

Purification Antigen affinity purification

Conjugate Unconjugated

Applications WB, IHC, ELISA

Positive Control mouse brain tissue, HepG2 cells

Format Liquid

Size 50 uL; 100 uL

Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Preservative 0.02% Sodium Azide

Storage Store at -20°C. Aliquoting is unnecessary for -20°C storage.

BACKGROUND

Introduction Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion

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Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Keywords KCNAB2; potassium channel, voltage gated subfamily A regulatory beta subunit 2; AKR6A5; KCNA2B; HKvbeta2; KV-BETA-2; HKvbeta2.1; HKvbeta2.2; voltage-gated potassium channel subunit beta-2; K+ channel beta-2 subunit; K(+) channel subunit beta-2; potassium channel shaker chain beta 2; potassium voltage-gated channel, shaker-related subfamily, beta member 2;

GENE INFORMATION

Entrez Gene ID 8514

UniProt ID A0A024R4E3

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]