The NIH Record U.S. Department August 5 National of Health 1980 Institutes and Vol. XXXII of Human Services No.16 Health

Role of Endoscopy Calvin Baldwin Named In Upper GI Blee.ding Topic of Next NIH Associate Director Consensus Conference For Administration A consensus development meeting on Calvin 8. Baldwin, Jr., has been named NIH Endoscopy: W hat Is Its Role in Upper GI Associate Director for Administration. Bleeding? will be held on Aug. 20-22 in the Mr. Baldwin, who has been executive officer M asur Auditorium. It starts Wednesday at of the National Cancer Institute since 1970, 8:30 a.m. will serve as principal adviser to the NIH The meeting, which is open to the public, Director on administration and management will address issues that have arisen over the concerns, and as Director of the Office of use of endoscopy in upper gastrointestinal Administration. bleeding. A native of Radford, Va., Mr. Baldwin The goal of the conference is to discuss the moved to Montgomery County in 1933. After relevant views of practicing physicians and serving in the U.S. Army from 1944 to 1946, experts in gastroenterology, liver diseases, he attended the University of North Carolina, endoscopy, radiology, and biostatistics so that where he received a B.A. degree. Later, he went to Harvard University, receiving the M r. Baldwin's productive career at NIH has led to general agreement can be reached on the cir­ his recognitio n throughout the Public Health cumstances appropriate for the use of master's degree in public administration there in Service as o ne of its most effective administrative endoscopy. 1961. leaders. A series of presentations will be concerned At NIH 27 Years NCI, 1970 to the present. with such questions as the risks and benefits Mr. Baldwin's Government career spans 30 He has received numerous honors and of endoscopy in upper GI bleeding, alterna­ years, 27 of which have been at NIH. He has awards, including the HEW Superior Service tive methods of diagnosis and management of held responsible positions in administration Award in 1973 for " exemplary performance upper GI bleeding, and indications and in four Institutes or Divisions of NIH. and leadership in the administrative imple­ contraindications for the use of endoscopy. These include: administrative officer, Divi­ mentation of the National Cancer Act of Following the presentations, a panel of ex­ sion of Research Services, 1957-58; adminis­ 1971." perts will develop a statement of consensus to trative officer, National Institute of General In 1960 Mr. Baldwin was awarded the be presented Friday morning, Aug. 22. Medical Sciences, 1958-62; executive officer, William A. Jump Meritorious Award for For further information, contact Yvonne National Institute of Child Health and Human "exemplary achievement in public administra­ Lewis, 983-0535. D Development, 1963-70; and executive officer, tion." D

Dr. Robert I. Levy, Director of NHLBI, Receives Van Slyke Award

Dr. Robert I. Levy, Director, National Heart, chemistry, for helping to develop clinical Lung, and Blood Institute, recently was chemistry as a major discipline in medical awarded the Van Slyke Award in Clinical science, and for high personal integrity and Chemistry by the American Association for devotion to human welfare. Clinical Chemistry. The Van Slyke Award is Dr. Levy was cited by the AACC as being the oldest and most "a world renowned authority and pioneering prestigious award investigator in lipid and lipoprotein transport, given by the AACC. lipid metabolism and medical approaches to Named for and atherosclerosis in relation to hyperlipidemia." first presented to Dr. Donald D. Van Award Presented at N.Y. Academy Dinner Slyke in 1958, selection of the Dr. Alan Portney, chairman of the New annual recipient is York metropolitan section of the AACC, made by a commit­ presented the award at a dinner in Dr. Levy's tee of Van Slyke honor at the New York Academy of Sciences. awardees. Dr. Levy also received an award for dis­ The award is given for outstanding scien­ tinguished research contributions from the A celebrity comes to N IH. (See Page 5.) tific contributions in the field of clinical AACC in 1979. 0 Auditions for 'Bell, Book, and Candle' Blood Donor 'Thank You' Party To Be Held Aug. 24, 25 Includes Variety of Door Prizes The NIH Record Auditions for roles in "Bell, Book, and Published biweekly at Bethesda, Md., by the Editorial Candle," will be held on Sunday, Aug. 24, at Operations Branch, Division of Public Information, for the 2:30 p.m. and on Monday, Aug. 25, at 7 p.m. informatio n of employees of the National Institutes of in the M asur Auditorium. Health, Department of Health and Human Services, and circulated by request to writers and to researchers in The play by John Van Druten is a delightful biomedical and related fields. The content is reprintable comedy in three acts-two female and three without permission. Pictures may be available on request. male players are needed. The NIH Record reserves the right to make corrections, changes, or deletions in submilted copy in conformity with Anyone interested in helping the produc­ the policies of the paper and HHS. tion in any capacity may call Sally Richardson, 496-4503. □ NIH Record Office Bldg. 31, Room 28-03, Phone 496-2125

Editor Affordable Montgomery County Housing Frances W. Davis Offered on Early Bird List Staff Writers William B. Reinckens An Affordable Homes Program in Mont­ Joyce F. McCarthy gomery County is offering a special service to Staff Corretpondent1 assure affordable housing for potential buyers CC, Angela Ducker; DCRT, Mary Hodges; DPM, Judy Fo uche; or renters who fall within certain moderate DRG, Sue Meadows; DRR, Barbara Menick; DRS, Arthur F. M oore; FIC, Toby P. Levin; NCI, Patricia A. Newman; income limits. NEI, Marsha Corbett; NHLBI, Bil l Sander<; NIA, Ann Dief­ Through the program's early bird list, the fenbach; N IAID, Jeanne Winnick; N IAMDD, Linda Cross; affordable homes staff will be offering units NICHD, Pamela D riscoll; NIDR, Sally Wilberding; NIEHS, Hugh J. Lee; NIGMS, Wanda Warddell; NIMH, Betty in seven new subdivisions to those eligible Zubovic; NINCDS, Doris Parker; NLM, Roger L. Gilkeson. to receive special advantages. To apply, pick up an application at the NIH Housing Office, Bldg. 31, Rm. B3C-02, 496-4973. □ TRAINING TIPS NIH Sailing Club Offers Course The T-shirt Karen Mayo is wearing will be a gift to The Division of Personnel Management is To Start Sept. 8 some lucky donors attending the party at the CC giving several courses in Office and Com­ Blood Bank. A course on basic sailing is being offered by munication Skills, 496-2146, and Supervisory The Clinical Center Blood Bank is throwing and Management Courses, 496-6371. the NIH Sailing Club on six consecutive Mon­ day evenings beginning Sept. 8, from 7 to a thank-you party for those employees who These courses start in September. For have donated blood. The party will be held starting dates and registration deadlines, see 9 :30, in Bldg. 31, Conf. Rm. 4. Water sessions will be held on Satu rday, on Wednesday, Aug. 13, from 1 to 3 p.m., in The NIH Record, July 22, 1980. For more the CC 14th floor auditoriu m. information, call the above numbers. □ Sept. 13, and three weekday afternoons from 2 to 7 p.m. The cost is $75. A variety of door prizes donated by the R&W Association will be given out. Among Registration Begins Aug. 13 the gifts will be a 1-day round trip for two by NIH Radiation Safety Officer Registration for the sailing lessons will begin bus to the Park Place Casino Hotel in Atlan tic Michael B. Musachio Retires on Wednesday, Aug. 13, at the R&W Activ­ City, N.J. , on Sept. 12. The trip includes an ities desk in Bldg. 31. Make checks payable to "all you can eat" buffet and priority admission Michael B. Musach io, NIH radiation safety N IHSA. Payment is required at time of to the casino. officer since 1973, retired from the Govern­ registration. Class is limited and will be Other door prizes include STOP Give Blood ment with over 26 years' service on June 30. selected on a first-come, first-served basis. T-shirts, a case of Coca-Cola, three dozen Upon his retirement, Mr. Musachio was For further information, call Wendy fresh Grantsville eggs, a box of Russell Stover presented with a Public Health Service Com­ Aaronson, 468-6586. D candy, and a selection of Napier jewelry. □ mendation Medal awarded for his outstanding work as NIH radiation safety officer. He was cited for "extraordinary leadership in radiation safety and dedicated commitment to the mission of the National Institutes of Health." His award was presented by Dr. W. Emmett Barkley, director of the Division of Safety, at a retirement dinner held at the National Naval Medical Center Officers Club on July 1. Mr. Musachio joined the PHS in 1962 after completing his master's degree in public health in sanitary science at the University of North Caroli na, His previous education in­ cludes a B.S.A. degree from the University of Georgia. During his PHS career, he has worked for the Indian Health Sel\'ice in New Mexico and South Dakota. Prior to joining the PHS, Mr. Musachio served in the U.S. Army in the early 1950's, and later worked in public health as a sa ni­ ta rian in New York State's department of health. In 1968, he came to NIH and w orked to control microbial hazards in the CC. Mr. Musachio's retirement plans include a Mr. Musachio (c), former chief of the Occupational Safety and Health Branch, holds the PHS Commen­ new career in agriculture. He will be running d.ition Medal certificate he received upon his retirement. Also at the ceremony .ire: Ors. Gerald S. his small farm on the Delmarva Peninsula. □ Johnson (I), chief, Nuclear Medicine Department, and chairman, Radiation Committee, and Dr. Bari

Page 2 The NIH Record August 5, 1980 Dr. Thomas A. Lambo, WHO Official, Praises NIH For Its Contributions to World Health

Dr. Thomas A. Lambo, deputy directo r­ general of the World Health O rganizatio n, discussed the relationship between W HO and NIH in helping to solve the w orld's health problems during a recent visit. Dr. Lambo, a Nigerian and internationally recognized as an authority in psychiatry and neurology, has served at WHO headquarters in Geneva, Switzerland, since 1973. His visit was coordinated by the Fogarty International Center. While here, he attended the B/1/D Directors meeting where he was introduced by NIH Director Dr. Donald S. Fredrickson. At the meeting, Dr. Lambo pra ised the agency as "the finest research institution in the world," noting that "NIH and W HO have much to offer each other, and our efforts should be coordinated vis-a-vis the health problems of the world." He also expressed the hope that NIH would continue to support the WHO position of Director, Office of Research Promotion and Development in Geneva. Currently, approximately $70 million is being spent by NIH for biomedical research related to WHO programs. Dr. Lambo (r-foreground) discusses WHO projects at Stone Hou_s e with NIN~ DS Director Dr. Donald B. Tower (I), NIA Director Dr. Robert N. Butler (c), and NIAID Director Dr. Richard M . Krause. Over $15 million is being spent by the col laborating center for the prevention of National Cancer Institute for such programs blindness. as: the European Organization for Research Recognizing that biomedical and health on Treatment of Cancer, International Union data are essential to research and training, Against Cancer, International Agency for WHO suggested that the National Library of Research on Cancer, and for the Pan Medicine use its computeri7ed information American Health Organization's cancer system, MEDLINE, to produce a specialized research. bibliography on tropical diseases. Today, NLM and WHO collaborate on such a quarterly Other Collaborating Centers bibliography. NLM is also continuing its sup­ Another WHO collaborating center is the port of PAHO's Regional Library of Medicine. National Institute or Environmental Health The National Heart, Lung, and Blood Sciences Office of Health Hazard Assessment, Institute serves as a WHO advisor in the long­ which studies environmental health problems. range planning of programs for cardiovascular This office also actively participates in the diseases and hypertension research. The United Nations Environmental Program. Institute also exchanges vital data on the Since 1975, the National Institute of Neuro­ ongoing U.S. Coronary Artery Surgery Study Dr. Fredrickson (I) greets Dr. Lambo in his office logical and Communicative Disorders and with participants in the European Coronary prior to a luncheon at Stone House in honor of Stroke has served as one of eight WHO the WHO deputy director-general's visit. Artery Surgery Study, a WHO coordinated collaborating centers in the neurosciences. program. Today, there are six NIH Institutes partici­ These centers, positioned strategically The National Insti tute of Child Health and pating as WHO collaborating centers in throughout the world, further international Human Development's Center for Population different research areas. research efforts in neurological disorders, and Research, the primary Federal effort in popu­ The intramural laboratories of the initiate community programs for prevention lation research, is continuing its close National Institute of Allergy and Infectious and treatment. collaboration with WHO population research Diseases serve as WHO collaborating centers Currently, special emphasis is being given programs. CPR provides biological testing for for rickettsial diseases, mycoplasma, and to stroke and epilepsy. Research protocols for long-acting contraceptive drugs that have respiratory viruses other than influenza. neuroepidemiology studies in developing been synthesized by WHO contractors. During the last year, WHO designated countries are being conducted now with Last year, hundreds of investigators overseas NIAID's M icrobiology and Infectious Diseases WHO. received reagents developed with NICHD Program as one of three collaborating centers Last year, the National Eye Institute awarded support. Presently, a joint effort is under way on interferon production. a 3-year contract to WHO to support to provide scientists with radioimmune assay The lnstitute's extramural programs also research on the epidemiology of blindness reagents for nonhuman primate pituitary provide indirect support to four active U.S. and its prevention. NEI, FIC, and WHO hormones. instituitons which serve as centers in research­ jointly sponsored a workshop at NIH to WHO and the United Nations, in conjunc­ ing arboviruses, enteroviruses, influenza, and develop a training manual for auxiliary tion w ith the National Institute on Aging, immunology. A large percentage of NI H's health workers to staff prevention of blind­ funding is being spent o n the study of tropical ness clinics. have sponsored the drafting of the 32nd and infectious diseases, both in the U.S. and NEI also maintains a close liaison with World Health Assembly Resolution on Health overseas. PAHO, and has been designated as a WHO /See WHO, Page 10)

August 5, 1980 The NIH Record Page 3 Emergency Air Conditioning Keeps Computers Dr. Henriette von Sallmann Dies; Running During Hot Spell Widow of Noted NIH Scientist Dr. Henriette von Sallmann, a retired ophthalmologist, died after a long illness in Vienna, Austria, on May 3. She was 84 years old. Her late husband, Dr. Ludwig von Sallmann, was renowned for his research in ophthal­ mology, particularly on cataracts and retinal disease. He came to NIH in 1956, and continued his research even after his retirement in 1970. ., He died in 1975. He and his wife had made many close friends among the NIH scientific community during their stay here. She is survived by her sister, Maria Jolles, and sister-in-law Caroline Sallmann, both of I Vienna. D · NCI Offers Computer Class For Research Scientists Scientists are becoming more interested in doing their own searches of computer-based information retrieval systems, a service usually Air-A-Plane Corporation's mobile air conditioning unit arrived at night and started pumping cool air the provided by medica l librarians and other next morning. The temperature reduction permitted the computer center to run without interruption. intermediaries. For this reason, a special half­ day training class in the use of CANCERLIN E Record-setting outside temperatures and The added cooling capacity enabled the data bases is being offered. equipment failure at the NIH Chilled Water center to operate al l of its computer equip­ The International Cancer Research Data Plant combined to force the shut down of ment at full capacity and to continue servicing Bank Program produces three cancer informa­ two of the four central processing units at its 6,500 normal users. tion data bases that are maintained an d usable the NIH Computer Utility on July 16. Over the next 2 days, the mobile cooling through the National Library of Medicine To avoid closing down the Division of unit augmented the existing cooling system computer system. Computer Research and Technology facility until necessary repai rs could be made. CANCER LIT is the largest data base, con­ completely because of rising temperatures, Staff Suggests Solution taining more than 200,000 abstracts of the computer center staff found a unique published cancer literature. Descriptions of A solution to the computer cooling system solution to the problem of furnishing enough current cancer research are found in cool air to prevent damage to the tempera­ fai lure was first effected in 1974, when similar CANCER PR OJ, and summaries of current ture-sensitive computer equipment. problems interrupted the supply of chilled cli nical protocols are avai lable through water to the computer center. Staff members CLINPROT. The three data bases are referred suggested the novel approach after witnessing to collectively as CANCERLINE. airplanes being cooled by such mobile The sess ion w ill provide a basic under­ cooling units. standing of the NLM information retrieval At that time, an arrangement was made for system and the three cancer data bases. It is putting the air conditioning service on ca ll if designed for the scientist who expects to do needed again. In October 1975, they were a limited amount of searching. Those inter­ called again. ested in ta king the class should call Kim Crim, 496-7403. Anyone interested in extensive searching o r in other NLM data bases should contact the National Library of Medicine, 496-6193, and arrange to take the standard 5-day train­ ing course. □

American University Offering Chilled air was forced through these tubes into Bldg. 12 from the mobile air conditioning unit. Nearby Work-Related Courses Air-A-Plane Corporation-a Norfolk, Va.­ American University is offering a variety of based mobile air conditioning unit company work-related courses starting Sept. 2 at that provides air conditioning to parked Georgetown Preparatory School in Rockville. airliners between scheduled flights-was = M ost courses are 3 credits and tuition is contacted to learn if it could dispatch one $705 per credit. Registration is on-site at the of its units to NIH. school in MacKavanagh Hall, 10900 Rockville A unit arrived during the night and was put Pike, on Tu esday, Aug. 19, o r Wednesday, into use the following morning. Two large Aug. 27, 5-8:30 p.m. yellow tubes carrying chilled air from the Registration can also be completed on AU's diesel-operated unit were run from the vehicle ca mpus, or at any off-campus location during parked o utside Bldg. 12 into the building, Plastic tubes filled with cool air ran the length of registration. For more informatio n, call and placed on the computer room floor. the computer center and reduced the temperature. 686-2500 or 496-2146. □

Page 4 The NIH Record August 5, 1980 'Rosie' Grier Huddles With Summer Employees By Calvin Jackson, Summer Intern 'Jones' society. Everyone wants to do better The NIH Block Heritage Summer Program than the 'Jones.' As opposed to us concen­ on July 21 featured ex-pro football star and trating on our individual talents- God-given community leader Roosevelt "Rosie" Grier talents-we're so busy developing our ability as the keynote speaker. The NIH Cultural and our attitude to take.'' Committee, chaired by Levon Parker, spon­ Mr. Grier is optimistic about the future, but sored the program. warned that people should take pride in Despite near 100° heat and the absence of their jobs and make :hemselves valuable to the originally scheduled keynote speaker, their employers. Dr. Benjamin L. Hooks, Mr. Grier received a He concluded, "the most beautiful thing is very warm welcome from a lunchtime crowd going to happen in the eighties if we begin that gathered to hear him on a hilltop near to put our eyes on that which is important in Bldg. 16. our lives, that issue of love, that issue of Dr. Hooks, Executive Director of the compassion, that issue of understanding National Association for the Advancement of towards other people irregardless of what Colored People, was unable to attend the they speak or what they look like. If we put program because of a last minute trip to our eyes on something greater than the cir­ Africa with Vice President Walter F. Mondale. cumstances surrounding us, we are going to Before his speech, Mr. Grier held a brief walk in victory over those circumstances." interview sess ion during which he answered Dr. Fredrickson greets "Rosie" Grier. In his introductory speech, Dr. Fredrickson various questions about his career. ca lled Rosie Grier a "Renaissance man" When asked how a retired football player about the welfare of our country, the need of because of his many dimensions. In addition stays in shape, Rosie jokingly replied, " don't scientific research, and the need of a better to playing professional football as a defensive eat so much." Moving away from the health attitude toward our individual citizens." ta ckle for the New York Giants and Los McKinley High School Band, which was NIH D irector Dr. Dona.Id S. Fredrickson Angeles Rams, Mr. Grier, who stands 6 feet practicing for the program, he answered, introduced Mr. Grier and urged summer 5 inches and weighs 280 pounds, is an accom­ "basically its not very d ifficult. employees "not to forget the paths that are plished singer, who made his debut at "You just have to realize that when you beginning to be established this summer." Carnegie Hall. give up the sport you're not as active as you Mr. Grier began his address by stressing the Rosi e is also an author and actor. Movie used to be, so what you have to do is watch need for people to start thinking about the fans may remember him from such films as what you eat. Try to get a nice balance of future. He used a combination of his personal In Cold Blood and Skyjack. He has also m, de eating habits." sports experiences and Biblical quotes as severa l television appearances, and this f; I In addition to good eating habits, Rosie examples. will have a recurring role as a wrestling C< ~ch also keeps in shape by working out in a gym, Mr. Grier also observed that despi te an on The White Shadow. jogging, and playing tennis. abundance of talent, the young people of Life, however, also had its unexpected ' .rns As to the role which he sees Blacks playing today are still worried about getting jobs. The and has not always been calm for Rosie. " fter in the medical field of the 1980's, Rosie said, problem, according to him, is that there is a 12 years, he sti ll refuses to discuss the nigl t "I see an increase of ac tivity on the part of lack of support and encouragement. that Senator Robert F. Kennedy was assass - all people in all phases of human services. I "We have unionized our kids out of the nated by Sirhan Sirhan. It was Mr. Grier, a should think that our colleges and all of our opportunity to play their instruments in some personal bodyguard of Kennedy's, who learning institutions are geared to be able to kind of club because everyone wants to get wrestled Sirhan to the ground. take on the influx of concerned young people more and more and more money. We have a "It was a tragedy in history and in my life. I never use it in any of my presentations. I wish I cou ld forget it, but 1 know I can't." The one sore spot in his football career is that he never scored a touchdown. "1 played 13 years and 1 never scored a touchdown. You have no idea how frustrating that can be." When one speaks to Rosie it is hard to imagine him as one-fourth of the "Fearsome Foursome." His pleasant personality and genuine concern for the welfare of others makes it impossible not to like him. D

Correspondence Study Program Catalog Now Available

The 1980-82 Correspondence Study Pro­ gram Catalog is now available through the U.S. Department of Agriculture's Graduate School. The catalog offers more than 40 courses in various subjects which can be taken by mail and completed within 1 year. Registration is open throughout the year, and forms are included in the catalog. To receive a copy of the Correspondence Study Programs Catalog, ca ll (202) 447-7123, Black Heritage Committee member Franklin iackson, introduces program particip.ants (I to r): NIH or write: Graduate School, U.S. Department of Director Dr. Donald S. Fredrickson, "Rosie" Grier, Calvin Jackson, summer employee, and Maggie Agriculture, Correspondence Study Programs, Johnson, DRG. South Bldg., Rm. 6849, Wash., D.C. 20250. □

August 5, 1980 The NIH Record Page 5 Ors. Choppin Summer Interns And Billingham Join NIAID Council Find Experience

Ors. Purnell W . Choppin and Rupert E. At NCI Unique Billingham have been appointed to the National Advisory Allergy and Infectious A greater number of minority students Diseases Council, effective through 1983. than ever before are taking part this year in D r. Choppin, a noted virologist whose the National Cancer lnstitute's summer intern primary research is on influenza and parain­ program. fluenza viruses, is a professor at Rockefeller O f the 30 interns, 10 are Black, 13 Hispanic. University and senior physician at the They represent 23 colleges and universities Rockefeller University Hospital. from the west coast to the East. All are in laboratory techn ical support He and his col leagues have shown that, posi tions. Every day they ta ke on research unl ike many viruses that are released o nly tasks from monitoring tumor growth in mice, after they kill the cell and cause its disruption, to extracting nucleic acids from tissues, to influenza and parainfluenza viruses are keying data into computers. assembled at the ce ll surface and are released A glimpse at some of the intern s on campus as individual buds. Cedric Shepheard, who just graduated from Mo rris Brown College in Georgia, is applying for dental reveals thei r talent and high ca liber. During this process the virus acquires an school. He takes tumors from rats, prepares Juan Jose Galarraga, a graduate b iology outer membrane whose lipids are derived membranes, then runs ribosylation reaction on student at Georgetown University, works in from the cell, but w hose proteins are v irus­ those membranes and does other chemical the Laboratory of Pathology. Among other specific. These proteins are responsible for analyses. pursuits, he is comparing nucleic acids from many of the important biological activities of tumors with those from viruses. the virus, including its ability t o attack and " This internship is broadening my experi­ infect a given cell. ence in laboratory techniques," he says. "I'm Dr. Billingham is professor and chairman of impressed with the resources, equipment, and the department of cell biology at the Univer­ energy here." sity of Texas Health Science Center, South­ Keen on medicine and research, Juan is western Medical School, at Dallas. writing a master's thesis on the interaction A pioneer i n the study of transplantation between white blood cells and tumor cells. immunology, Dr. Billingham was among the Sherra Fluellen of Georgia's Fort Valley first to show that transplantation rejection was State College works in the Laboratory of initiated by the immune process. Pathophysiology. She enters Howard Uni­ Dr. Billingham's current research is focused versity's medical school this fall. on mammalian reproduction as a form of Interns Active in College successful transplantation. He has produced evidence that white cells in the mother's milk In college Sherra worked in an NIH­ along with maternal antibody may offer some sponsored Minority Biomedical Support protection to breast-fed babies. D Program. She also was vice president of the scientific honorary society Beta Kappa Chi and president of the science club. Dr. King Appointed Director, This summer Amy Martinez is working in Kennedy Institute of Ethics Michael Torres, who majors in biomedical engi­ the Laboratory of Molecular Biology. She neering (electrical) at the University of New majors in biology and chemistry at Metro­ Dr. Thomas J. King, National Cancer Insti­ Mexico, is using the electron microscope for poli tan State College in Colorado, and plans research in membrane biology. tute, has been appointed di rector of the Ken­ to attend medical school. nedy Institute of Ethics, Georgetown Univer­ "I've always been curious about research sity, effective Aug. 1. and it has been fantastic. But I'm more The Institute, composed of the center for oriented to working w ith people," she says. bioethics, the center for population research, "The internship has provided an excellent and the laboratories for reproductive biology, opportunity for finding this out." is an interdisciplinary research and study " People here are tops in their fields," says center for physicians, scientists, historians, Matthew Jimenez, a University of Utah lawyers, philosophers, and theologians. D sophomore who won a scholarship through the Ethnic Minority Health Science Organi­ Also Holds Academic Post zation. "This experience is broadening my He will also hold the post of professor, horizons, and helping me with my future department of obstetrics and gynecology, goals. You have to try things out to find Georgetown University School of Medicine. where you want to go." In the Laboratory of Biochemistry, Matthew Dr. King is leaving his position as director will learn techniques l ike column chroma­ of the Division of Cancer Research Resou rces tography. He will contribute to an ongoing and Centers to re turn to Georgetown where he was a professor of biology from 1967 to project with nuclear and granular proteins. 1972. In addition, he was a professional His current career choice? " I'd like to be a lecturer at Georgetown's department of surgeon." obstetrics and gynecology, and developmental A graduate student in biology from North biologist at the Kennedy Institute. Carolina Agricultural and Technical State University, Kevin Brown assists in the D r. King joined NCI in September 1972, Sherra Fluellen says, " I'm growing human breast Laboratory of Cell Biology. and was named director of the research divi­ cells in vitro and in vivo with mice. ll's giving sion in 1974. D me experience I might need for medical school." (Conlinued on Page i)

Page 6 The NIH Record August 5, 1980 (Continued from Page 6) " I'm personally fascinated by the many Aluminum able scientists here and by the opportunity Concentrations to am ass so much know ledge by working on d ifferent aspects of a problem," he says. Found in Brain Tissue For the Laboratory of Viral Carcinogenesis, Charlotte Sanders of Tennessee's Fisk Associated University collects data from the experi ments of three lab sections, analy, es it, draws graphs With Senile Dementia and enters findings into computers. She also tests animal and human blood for antigen­ Research has shown high concentrations of antibody reactions. aluminum in certain regions within the " I feel as though I' m a vital part o f the brains of elderly senile individuals compared lab, not just a summer student," she says. A with amount found in the brains of alert winner of academic awards and scholarships, individuals. But the precise location of the Charlotte is majoring in civil engineering aluminum has been hard to find. and math. Now, in a recently reported study, scientists " M y secret desire," she says, " is to go to from the National Institute of Environmental law schoo l. But I' ll probably attend medical Health Sciences and the Universi ty of Vermont school and end up in research. I'd rather be have pinpointed the location. The finding may i n the discovery part than in di rect contact Amy Martinez is examining enzyme activities and lead to a better understand ing of senile w ith people." bacteria mutations in the laboratory this summer. disorders afflicting an estimated 500,000 to The NCI summer intern program is part of 1.5 mi Ilion elderly and middle-aged persons. a larger NIH program. In a report published in the April 18 issue "For the past 6 years, this student program of Science magazine, the investigators found has been an excellent way to enrich the al uminum concentrated w ithin certain research experiences of minority students," abnormal neuro ns typically found in the says Marianne Wagner, NCI personnel officer. brains of patients with senile dementia or It is designed for students who w ill return Alzheimer's d isease. Adjacent normal appear­ to school in the fa ll and who can share their ing nerve cel ls, however, were virtually free experience w ith others interested in similar of detectable amounts of the metal. subject areas. Brain tissue samples were taken at autopsy The NCI ~urnmt>r intern'i and the laboratories o r areas in from three subjects aged 74, 79 and 82, all which thry ..ire working dre: with a clinica l history of severe dementia. Joseph Alvar~z. l mmunob,ology; Kevin Brown, Cell Biology, Mary,rnn Brown, Carcmogen Metabolism; Rose Besides aluminum concentrations, other Dovalrna, Molecular Biology, Varner D udley Ill, Biology; Allynda Dunlop, Medicinal Chemistry and Bio logy; Robert conditions highly characteristic of senile Dyer, Cht:'rnrc.al Ph.aunacology; Sherra rluellen, Pachophysiol­ dementia were found. These were the pres­ ogy; Oralia fri,nco, hnmunology; Jua n Jose Galarraga, ence of senile p laques and abnormal filaments Patholo8y; rrank Gallegos, Biochemistry; Rosemarie Garza1 Chemical Pharm(1cology, 1\.11 rrial Hunter, Chemic.11 Pharma­ in the nerve cells ca lled neurofibrillary cology; Manhcw f1 rnenez, Biochemistry; Brodis ~, Marr, tangles (NFT's). Immunology: and l,1c.l,. long, Biochemistry. Also, Amy V\artine.:, Molecular Biology; Deborah Martine~, In contrast, autopsied control patients Med1einal Chemrc, lry and Biology; Glenn Matthe\'V~, Bio• aged 74, 87 and 94, who were mentally alert chemistry; Jose PJgan Lajara, VA-Medical O ncology; Sylvia Pa,, P,11hology: ,\ h rhael Ragland, Molec11 lar Viro logy; prior to death, showed very few NFT and MJrina Ramire7, Mrdidnal Chemistry and Biology; Charlolte little senile plaque formation. Sa nders, Vi ral C1rcinogcne,1s; Dale Linda Scott, Environ­ ment,,! Ep,dcrniology Brand,; Jeffrey Sekel, lmm11nology Allynda Dunlop, a premed-major, is a senior at Previous resea rch showing aluminum r ro~ram: Cedric She1,heord, ra1hophysiol0By; Andrew Smilh, Viral Carcinogenesis; Michael Torres, Pa1hophysiology; and Virginia Union University. She is studying anti­ accumulation in the brain tiss ue of elderly Henry Wolfe, r heoretical Biology. tumor drugs and their effects on mice. patients did not indicate the specific location. Using X-ray spectrometry and a scanning Photos by Lewis Bass electron microscope, Dr. Daniel P. Perl, department of pathology at the University of Vermont in Burlington, and Dr. Arnold R. Brody, laboratory of pulmonary function and toxicology, NIEHS, were able to determine the aluminum content of neurons in that portion of the brain called the hippocampus. Aluminum can be found vi rtually every­ where o n the earth's surface, yet it has no known biologic function and is not consid­ ered essential to the diet. The chemical has been implicated as a neurotoxin in brain disease associated with chronic hemodialysis o r so-called " dialysis dementia." Patients with this condition are reported to have brain aluminum concentrations 12 times normal, w hile dialyzed patients without brain d isease have an intermediate brain aluminum concentration. A lthough no causal relationship has yet been demonstrated between aluminum, neurofibrillary tangles, and Alzheimer's Kevin Brown is a graduate student who is working this summer in the laboratory of Cell Biology. He disease, this research could be an important teaches general biology and tutors undergraduates at North Carolina Agricultural and Technical Stale step in establishing the role of aluminum in University through an NIH-funded program, Minorit y Access to Research Careers. the disease. D

August 5, 1980 The NIH Record Page 7 Dr. John Heller Career Ed. Center Offers VISITING SCIENTIST Completes Appointment 60 College-Level Courses PROGRAM As Consultant The NIH Career Education Center is offering over 60 college courses at NIH for employees PARTICIPANTS during the fall semester which begins _Aug._ 25. The courses are given through the University Reported Fogarty by of the District of Columbia, a fully accredited International Center institution. Classes are scheduled at various times 7/1-Dr. In-Kyung Kim, Korea, Laboratory of General and Comparative Biochemistry. throughout the day-before, during, and Sponsor: Dr. G. L. Cantoni, NIMH, Bg. 36, after normal working hours, and on Saturday Rm. 3A19. mornings. Release time may be granted to 7/1- Dr. lsamu Kitanaka, Japan, laboratory of participants. Clinical Sciences. Sponsor: or: William Potter, Any HHS employee is eligible to attend if NIMH, Bg. 10, Rm. 4S239. he or she meets the following criteria: 7/1-Dr. Margarita E. Kullick, Mexico, Arthritis possesses a high school or General Educa­ and Rheumatism Branch. Sponsor: Dr. James tional Development (GED) diploma, meets E. Balow, NIAMDD, Bg. 10, Rm. 3N116. eligibility for training under p rovisions of 7/1-Dr. Yoshiomi Mohri, Japan, Clinical FPM 410-5, and is approved by the CEC Neurosciences Branch. Sponsor: Dr. Susumu director. Sato, NINCDS, Bg. 10, Rm. 4N262. Educational costs are paid from the HHS 7/1-Dr. Abraham K. Munabi, Stateless, Neo­ Secretary's Combined Fund at no cost to the natal and Pediatric Medicine. Sponsor: Dr. students or their agency. James Sidbury, NICHD, Bg. 31, Rm. 2A50. In the course of his career, Dr. Heller has received Interested persons may obtain a recently 7/1- Dr. Thomas Pe ff, USA, Arthritis and a half dozen medals and awards and four honorary printed 1980-81 Career Education Center Rheumatism Branch. Sponsor: Dr. John degrees, and served on the editorial boards of five scientific journals. In addition, Dr. Heller has ap­ Course Schedule from Bldg. 31, Rm. 4B-03, Decker, NIAMDD, Bg. 10, Rm. 9N222. peared on the cover of TIME magazine, and is a or by calling 496-5025. 7/1-Dr. Claudia Quijano, Colombia, labora­ member of the South Carolina Hall of Fame, his Among the credit courses being offered tory of lmmunogenetics. Sponsor: Dr. Thomas home stale. are: career assessment and life planning, J. Kindt, NIAID, Bg. 8, Rm. 100. reading skills improvement, fundamentals of 7/1-Dr. Eric Sariban, Belgium, Clinical On­ Known for his leadership in cancer research, journalism, public speaking, English compo­ cology Branch. Sponsor: Dr. Arthur Levine, Dr. John R. Heller completed his appointment sition, technical writing, principles of NCI, Bg. 10, Rm. 3812. as consu ltant on international activities for economics, reading skill in foreign scientific 7/1- Dr. Shigeki Shibahara, Japan, Pulmonary the National Cancer Institute on Aug. 1. He languages, basic conversational Spanish, Branch. Sponsor: Dr. Ronald Crystal, NHLBI, served as the fourth director of NCI from principles of psychology, introduction to Bg. 10, Rm. 6006. 1948 to 1960. logic. 7/1-Dr. Narayan M. Shivapurkar, India, Before 1948, Dr. Heller headed the PHS In addition, other courses include: intro­ Laboratory of Carcinogen Metabolism. Spon­ civilian venereal disease program during duction to political science, working with sor: Dr. Lionel A. Poirier, NCI, Bg. 37, Rm. World War II. During his 12-year administra­ older people, organizations and administra­ 3C24. tion, NCl's budget quintupled, with chemo­ tion in aging, death and dying, sociology of 7/1-Dr. Teepu Siddique, Pakistan, Medical therapy and the Pap smear test emerging as working women, fundamentals of accounting, Neurology Branch. Sponsor: Dr. W. King significant techniques for the control of basic computer language, government prop­ Engel, NINCDS, Bg. 10, Rm. 10D18. cancer. erty management, Federal b•1dgeting, biology, 7/1-Dr. Staff.in Smeds, Sweden, laboratory of From 1960 to 1964, after his retirement from immunology, general genetics, chemistry, and Molecular Biology. Sponsor: Dr. Seymour H. NCI, he served as president and chief execu­ Wollman, NCI, Bg. 37, Rm. 1E16. mathematics at various levels. tive officer of the Memorial Sloan-Kettering Short courses will also be offered in 7/1 - Dr. Usha Srinvasan, India, Pediatric Cancer Center in New York. Later, Dr. Heller Oncology Branch. Sponsor: Dr. Arthur S. planning conferences, meetings, and work­ became vice chairman of the center's board shops; medical terminology; and on the Levine, NCI, Bg. 10, Rm. 3813. of trustees and served as special consultant metric system. □ 7/1- Dr. Tan-chun Tung, PRC, Division of on international, medical, and scientific affairs Bacterial Products. Sponsor: Dr. Darrell T. Liu, to the American Cancer Society. BB, Bg. 29, Rm. 425. In August 1965, he returned to NCI as an 7/1 - Dr. Gregory A. Ubom, Nigeria, Labora­ expert in international programs. □ USDA Offers Courses tory of Biophysics. Sponsor: Dr. Harold lecar, For 1980 Fall Quarter NINCDS, Bg. 36, Rm. 2A31. 7/2- Dr. Jacques Jo livet, Canada, Clinical The U.S. Department of Agriculture's Pharmacology Branch. Sponsor: D r. Bruce Graduate School is offering day, evening, and Chabner, NCI, Bg. 10, Rm. 6N119. Bike Thefts Hit NIH; correspondence courses to adults interested 7/2- Dr. Motonori Ohno, Japan, Laboratory of Locks and Chains Urged in improving job skills or pursuing new Chemical Biology. Sponsor: Dr. C. B. Anfin­ interests. sen, NIAMDD, Bg. 10, Rm. 9N307. A rash of bicycle thefts have occurred The deadline date for mail registration is 7/6-Dr. Amos Oppenheim, Israel, Laboratory recently on campus, say the NIH Special Se pt. 2. In-person registration will be Sept. of Molecular Biology. Sponsor: Dr. Max Police. Bicyclists who commute every day to 13-27. Gottesman, NCI, Bg. 37, Rm. 4B03. work and park their bikes are being encour­ Some of the new courses offered are: 7/7-Dr. Joseph Deutsch, Israel, laboratory of aged to purchase a high quality case-hardened Clients' View of Consulting; Public Informa­ Molecular Carcinogenesis. Sponsor: Dr. Harry chain or cable, along with a high-grade lock. tion Management; Civil Service Reform Act; Gelboin, NCI, Bg. 37, Rm. 3E24. Security Measures Help A Survey and Evaluation; Advanced COBOL 7/7-Dr. Kwang Sam Koh, Korea, Laboratory Techniques; Tax and l egal Aspects of Real of Cellular and Molecular Biology. Sponsor: These security measures, say police, will Estate Transactions. Dr. )hong S. Rhim, NCI, Bg. 37, Rm. 1A03. serve to slow down any potential thief and For more information, class schedules, and 7/8-Dr. Gerald Y. Minuk, Canada, Liver Dis­ could possibly aid in an arrest. the new 1980-82 Graduate School USDA eases Section. Sponsor: Dr. E. Anthony Jones, Any employee who observes someone Catalog, visit Rm. 265-A, Nat_i onal Press Bldg., NIAMDD, Bg. 10, Rm. 4D52. tampering with a bike is asked to call the 529-15th St., N.W., Washington, D.C.; or call NIH Police, 496-5685. □ (202) 447-4419. □

Page 8 The NIH Record August 5, 1980 Anne Shahan, ORR, Retires After 28 Years; Benefactor of West African Foreign Students Anne Shahan, a grants management spe­ Harold, who had just started working at the cialist in the Division of Research Resources, General Accounting Office. has retire d after 28 years of service. An The Shahans had two sons, Michael, now a extensive traveler in Africa, Europe, and me mber o f the Philad e lphia Orchestra, play­ Hawaii, Mrs. Shahan is a benefacto r of ing a double bass "on the first stand," and numerous Black foreign students from West John, the owne r o f an a ir-conditioning Africa. business in Flo rida. A native of Harrison County, W . Va., Anne Anne starte d back to work in 1952 as a came from "farm stock" where her fore­ clerk-typist fo r the then National Institu te of fathers raised Hereford cattle. He r fathe r Arthritis and Metabolic Diseases, where she taught school in a 2-room schoolhouse and later became a supervisor a nd grants assistant. her mothe r d ied w hen she was 9. At an early In 1963, she transferred into the newly orga­ age, Anne assumed the ro le of the female nized Division of Research Facilities and head o f the ho useho ld. Resources, now DRR. During the depression, she graduated from In 1968, she was promoted lo comm ittee Salem College where she acq uired a bachelor management officer, and in 1972, Mrs. of arts degree. She came to Washington, D.C., Shahan became a grants management spe­ in 1934, and got her first job as a bid reporter cialist, concentrating mainly in the area of with the Fidelity Deposit Company of Mary­ grants and contracts for the animal resources land. Soon after, she married her husband, program. A recipient of numerous specialty awards during her career, Anne was presented with the Division's EEO Award in 1973. For many Mrs. Anne Shahan and her husband, Haro ld, enjoy years she served on the DRR EEO committee her retirement luncheon. as secretary and chairperson. Since 1967, Mrs. Shahan has been personally doin College in Maine, got his master's involved in supporting student minorities, degree in law and diplomacy from Tufts mostly from West Africa. When her niece, University, and is now assistant secretary of Arvilla Payne was living with the Shahans the National Draught Relief Secretariat in The while attending American University, one of Gambia. her professors called Mrs. Shahan and A succession of West Africans, mostly stu­ described the plight of a young man from den ls, has passed through the Shahan home The Gambia, West Africa. or received financial aid from them during the According to Anne, most of the young past 10 years. Currently a student from The black people arriving in the U.S. for higher Gambia is residing with the Shahans while education experience cultural shock. "They attending Howard University as a journali sm have very little money and desperately need and broadcasting major. D Anne Shahan's reputation as the Bethesda bene­ family, from a psychological standpoint," she factor to West African students apparently has been well circulated. When she visited The says. Gambia several years ago, she was treated royally Tamsier M'Bye from The Gambia was the by friends and family of her "adopted students." first West African the Shahans took into their "They all called me Aunt Anne," she says. " I was home. They supplied food and lodging and guided from village to village as a VIP person and some funds for 5 years. treated with the utmost hospitality." Mr. M'Bye graduated cum laude from Bow-

Clinical Nutrition Award Nominations Invited

Nominations are invited for the 1981 Mc­ Collum Award of the American Society for Clinical Nutrition. The $1,000 award is admin­ istered by the National Dairy Council. The award is given each year to the indi­ vidual who, by investigations of biological processes, etiology of d iseases, and methods of treatment and control, has made a dis­ tinguished contribution to the field of clinical nutrition w ithin the past 5 years. Applications are being accepted until Oct. Dr. Herbert Bro wn, 1979 No bel Prize Winner in 31. Nominees and nominators need not be Chemistry and NIGMS grantee since 1963, has been chosen to receive the American Chemical Society's members of the society. 1981 Priestley Medal. The gold medal, the most For more information, contact G. M. Knight, prestigious award given by the Society, is pre­ (301J 530-7110. D se nted for distinguished services in chemistry. Dr. Brown will be presented with the medal at the 181st National Meeting of the American Chemical Society in Atlanta, Ga., Apr. 30, 1981. He received the Nobel Prize for his discovery of the hydrobora­ Fu Sing Temple has been appointed Equal assistant to the EEO director of NIMH. Mrs. Temple tion process which involves the use of boron­ Employment Opportunity Coordinator for the holds a bachelor's degree in psychology from the containing substances to initiate and speed National Institute of General Medical Sciences. University of California, whe re she spent 15 years clhemical reactions between compounds that con­ Prio r to her appointment, she served 1 year as in the Lawrence Be rkeley laboratory. tain carbon and hydrogen atoms.

August 5, 1980 The NIH Record Page 9 Division of Safety Appointees Will Maintain George Perrott, PHS Healthy Environment at NIH Biostatistician, Dies Inc. While there, he served as project man­ ager for an NCI contract to monitor biological George St. John Perrott, 86, a retired bio­ containment facilities. statistician and physical chemist, who directed Dr. M cKinney was directo r of productio n at many U.S. Public Health Service studies, d ied M icrobiological Associates from 1971 to 1976. of cancer on June 29. Between 1960 and 1970, he held several During his 25 years with PHS, Mr. Perro tt important posts w ith the U.S. Army Medical served as health Resea rch Institute for Infectious Diseases. planning and analy­ Previously, he served in several Army medical sis adviser to three laboratories. Surgeons General. Dr. McKi nney received his B.S. degree from He directed the Indiana State University, an M.S. in micro­ National Health Sur­ b iology from NYU, and a Ph.D. in epidemio­ vey of 1935-36, a !ogic science from the University of M ichigan. house-to-house He has written extensively on vaccine studies. canvass of the health status of a Mr. Barbeito was named chief of the Safety scientifically Operations Section of the Occupatio nal Safety selected sample of and Health Branch, w hich is responsible for 2½ million people conducting a comprehensive intramural safety George Perrott in 90 cities. program. The program applies to all NIH This survey provided the basis of national work places. estimates and projections of the prevalence of Dr. McKinney has served as a technical advisor to In the same branch, Dr. Mahar heads the illness and disability until the continuing the National Cancer lnstitute's safety programs and Technical Assistance Section. This section pro­ National Heal th Survey was established under to the N IH Recombinant DNA Advisory vides a multid isciplinary scientific and engi­ his d irection in 1956. Committee. neering team to develop a program to assess Fo llowing his retirement from PHS in 1958, unusual hazardous conditions with special Mr. Perrott organized and conducted an Recently several important appointments emphasis on situations pecu liar to biomedical international conference on health studies of were made in the Division of Safety, Office of research. human populations for NIH. Resea rch Services. These appointments are to Mr. Kremer is chief of the Environmental In 1962-63 he became the first director of be fil led by: Dr. Robert W. McKinney, Manuel Assessment Section in the Environmental research and statistics for the Group Health Barbeito, Dr. Harry Mahar, M ichael J. Kremer, Protcctfon Branch. This b ranch sponsors or Association of America, and his studies of and Roger W. Broseus. conducts research to define the re lationship Federal employees' experience in prepaid Dr. McKinney is joining the Division of between environmental quality and the per­ group p ractice plans provided the basis for Safety to develop the Occupational Safety and formance of medical research. Congressional enactment of the Heal th Heal th Branch, which administers programs It provides a technical and administrative Maintenance Organization Act of 1973. to maintain a safe and healthy enviro nment service to coordinate NIH compliance with Mr. Perrott was a private consultant from at NIH. Fed eral, state, and local resource conserva­ 1963 to 1975. He is survived by his w ife, Ru th An expert in laboratory safety, Dr. McKin­ tion, environmental protection, and pollution L., of Bethesda. D ney has extensive experience in research with control regulations. pathogenic microorganisms and in manage­ As acting radiation safety officer, M r. ment of multidisciplinary programs concerned Broseus will also serve as acting chief of the with safety. Radiation Safety Branch. In recent years he WHO From 1976 to the present, he held the post has coordinated the radiation safety training (Continued from Page 3) of senior microbiologist at Enviro Contro l, courses at NIH. D Care of the Elderly. It has also participated in the drafting of the U.S. recommendations for A booklet entitled Poison Ivy Allergy offers Booklet Gives Tips the World Assembly on the Elderly that will tips on how to avoid poison ivy plants. be held in 1982. On 'Poison lvv For a copy, send $1 to the Consumer The Division of Research Services was Allerav' Information Center, Dept. 203H, Pueblo, designated as the WHO center for defined Colo. 81009, or NIH employees may call the Poison ivy is itchy and uncomfortable and laboratory animals. DRS maintains over 200 National Institute of Allergy and Infectious not something you want to get if you can help stocks and strains of genetically defined and Diseases, 496-5717, to obtain the booklet. D it. Many people have an allergic reaction. monitored rodents and rabbits that serve as It is especially difficu lt to avoid poison ivy a source of animals for use by NIH and and poison oak since they grow almost international researchers. everywhere- in Employees Who Edit back yards as well Invited To Participate Mr. Oviatt is in Geneva as in woods and In Training Needs Survey Presently, Vinson R. Oviatt, former chief pastures. Long of the Environmental Sa fety Branch, DRS, is sleeves, long The Training Assistance Branch, DPM, is serving as Program Coordinator, WHO Special trousers, and gloves studying the train ing needs of editors, edi­ Program on Safety Measures in M icrobiology, will help to guard torial assis tants, and other personnel involved for 2 years at W HO headquarters in Geneva. against exposure in in editorial work. heavily weeded In cooperation with a committee of editors The activities described are just a part of areas. and editorial assistants, the training staff has the WHO-related projects to which NIH Animals may developed a survey form to elicit data about B/1/ D's have contributed. carry the resin on specific skills and knowledge needed to per­ During his visit, Dr. Lambo held separate their fur so if the form editorial work. meetings with several Institute Directors and Poison Ivy family pet has If interested in participating in this project, w ith NIH Deputy Director Dr. Thomas E. contacted these plants, be sure to give it a call the Training Assistance Branch, 496-2146, Malone, w ho was NI H's representative to the bath. for a survey form. D World Health Assembly held in Geneva. D

Page 10 The NIH Record August 5, 1980 interval without disease for some postmeno­ Breast Cancer Surgery and Chemotherapy pausal women. These preliminary findings clearly justify Will Aid Premenopausal Women, Says Panel continuation of careful research, but the data are not yet adequate to recommend routine Ongoing breast cancer studies have pro­ A woman and her primary physician should use of chemotherapy for postmenopausal vided clear evidence that combination chemo­ call on a multidisciplinary cancer treatment women whose disease has spread to their therapy following surgery will benefit team, experienced in technique and versed in lymph nodes, the panel said. current research, to help with the difficult premenopausal women whose cancer has Clinical research is beginning to suggest decision-making and treatment process, they spread to the lymph nodes. that hormonal therapy added to chemo­ said. This is the conclusion reported by a therapy also may improve survival. However, National Cancer Institute consensus panel that A woman's response to treatment and the investigators still must unravel the relative likeli hood of the disease recurring depend on met July 14-16 in the Masur Auditorium. The roles of hormonal therapy and chemotherapy at least 12 combinations of factors, the panel panel was charged with assessing the role of in the treatment of breast cancer. adjuvant chemotherapy in breast cancer as cautioned. They also must define the significance of A woman may be pre- o r postmenopausal; part of the NIH consensus development the effects of chemotherapy on a woman's have no spread of disease to her lymph nodes process. own hormonal function and the reliability of involvement of one to three lymph nodes or ' Adjuvant chemotherapy is the use of drugs hormone receptor assays in patients under­ spread to four or more nodes; and her tumor toxic to cancer cells in addition to a primary going these treatments. may be positive or negative for estrogen form of treatment to remove all evidence of The panel encouraged further research on cancer. In most cases, primary treatment is the receptors. the use of hormone therapies in combination mastectomy, surgical removal of the breast. An adjuvant chemotherapy clinical trial with drugs, but they said too much remains to Improvements in survival appear to out­ must provide enough patient data for analysis be learned for them to recommend hormonal of each of these factors before the results of weigh the risks of sho rt term or acute effects therapy pl us chemotherapy as standard treat­ the trial are given a role in determining cur­ of chemotherapy for premenopausal women ment. In particul ar, they suggested studies in rent medical practice, the panel indicated. who, through microscopic examination of postmenopausal women. Assessing the impact of these prognostic nearby tissue, have been found to have dis­ Dr. .Stephen K. Carter, a medical oncologist ease in the axillary (armpit) lymph nodes, factors, the panel agreed that no conclusive and director of the Northern California Can­ the panel concluded. evidence of benefit from chemotherapy has cer Program, Palo Alto, Calif., chaired the Acute toxic effects of drugs may include been found in women without microscopic panel. evidence of disease spread to the lymph bone marrow suppression, nausea and vomit­ The panelists included a breast cancer ing, loss of appetite, weakness, mouth sores, nodes (stage 1 breast cancer). patient and representatives of the disciplines Studies show that 80 percent of these and hair loss, the panel noted. They also involved in the evaluation and treatment of identified psychological problems as a risk for women survive for 5 years or more after breast cancer. some women undergoing repeated chemo­ surgery alone without the disease reappearing. Program director was Dr. Daniel G. Haller, Consequently, the panel did not advise its therapy. chief of the Medicine Section of the NCI Because chemotherapeutic drugs are toxic, routine use for stage 1 patients. Division of Cancer Treatment. D they should be administered only by, or under Recent analys is of several ongoing studies the supervision of, a physician experienced appears to show that adjuvant chemotherapy in their use, the panel warned. after surgery for breast cancer lengthens the Gail Patrick Velde Dies Gail Patri ck Velde, a former member of the Margaret D. Traynor Retires From Procurement Branch, DAS National Advisory Arthritis, Metabolism, and Digestive Diseases Council, 1972-76, and of Margaret D. Traynor recently retired from again in 1956 in the Supply Management the National Commission on Digestive Dis­ the Procurement Branch, DAS, after 32 years Branch (now the Procurement Branch). eases, 1978-79, died of leukemia at her home of service. Mrs. Traynor worked for that organization in Hollywood, Calif., on Ju ly 6. Mrs. Traynor first started working for the Born Margaret Fitzpatrick in 1911, she left Federal Government in 1944 at the U.S. Treas­ in various capacities until her retirement as supervisor of the biomedical equipment unit the study of law at the University of Alabama ury Department. She came to NIH as a mail in the mid-1930's to pursue an acting career. clerk in 1950, resigned in 1955, and started of the Purchase Operations Section. later, she became a TV producer, best known for the Perry Mason series. Miss Patrick, who was a diabetic, served as the fi rst chairman of the board of the Ameri­ can Diabetes Association in 1973. Her concern with health matters led to her appointment as 1970 national honorary chair­ man of the Christmas Seal Campaign. She was also an active lay member of several health science advisory boards at UCLA. D

Used Eyeglasses, Frames Needed The Society for the Prevention of Blindness is seeking aid for the Save Our Sight program. Contact Ronica Schwartz, Federal Bldg., Rm. 802, or Charlotte Jackson, Rm. 808, 496-5825, if you can contribute: • glasses with good plastic frames; • metal frames in any condition; • sunglasses (not clip-ons); • good plastic frames for reuse; M rs. Tr~ynor isddfe_lighted by red carpet treatment and limousine service to her r-etirem--­ent luncheon Her • discarded bits of gold or silver jewelry co-wor ers an nends gave her a color TV as a parting gift. · (metal is reclaimed). D

~ugust 5, 1980 The NIH Record Page 11 Leading Chinese Neurologists Visit NINCDS Dr. di Sant' Agnese Honored For His CF Research To Learn About Multiple Sclerosis At lnternat'I Congress In Canada Dr. Paul di Sant' Agnese, chief of the Pediatric M etabolism Branch of the National Insti tute of Arthritis, M etabolism, and Diges­ tive Disea ses ior the last 20 years, was honored by present and former clinical and research associates at a scientific banq uet at the recent Eighth Intern ational Congress on Cystic Fibrosis in Toronto, Ontario, Canada. The ceremony honored Dr. di Sa nt' Agnese as one of the pioneers in cystic fibrosis research and the mentor to m any o thers w ho have assumed leadership roles in the field of cystic fibrosis an d related diseases.

12 Speak at Banquet Twelve speakers addressed the gathering of 160 scientists from the i nternational CF community. They included banq11et organizers Ors. Lynn Taussig and Thomas Boat; Professor E11ore Rossi of Bern. Switzerland; Cystic Chinese neurologists discuss MS research with Dr. Dale Mcfarlin in the NINCDS Laboratory of Neuro­ immunology. l to r are: Drs. Feng; Zhao; Li Choh- Luh (of the NINCDS Surgical Neurology Branch); Drs. Fibrosis Founcl,1Iion President Doris Tulcin; Tower, and Mcfarlin. err Medica l/Scientific Direclor Dr. Robert Beall ; the fir~t CFF presirlent, Dr. Milton Two leading neurologists from the People's Graub; and International Cystic Fibrosis Republic of China visited NIH in June to see Association PresidPnt Robert Mccreery. firsthand U.S. research on multiple sclerosis. Drs. Feng Ying-Kun and Zhao Bao-Xun Founded International Group toured NIH clinical and research laboratories Dr. di S.ini'Agne, e w.is the medic,1 1 founder as guests of the ationa l Institute of Neuro­ logical and Communicative Disorders and of the lnlern,11ional Cy,tic Fibrosi- J\sc;ociJlion Stroke and the National M ultiple Sclerosis Jnd cofounder ot the Cystic f ibrosis Founda­ Society. tion. D r. Feng, 71, is chief of neurology at the I le w;is p rt>,entcd the first M edical Award of Capital Hospital in Beijing. Dr. Zhao, 62, is a Merit by the Cys tic Fibrosis Foundation for neurology professor at Capital Hospital, and his numerous Jccompli,hmenls in CF re,earch editor of the Chinese Journal of Neurology and hi, active role in physiciJn and patient and Psych iatry. education. D The Capital Hospita l was opened in 1921 as the Peking Union Medical College Hospital, and was supported by the Rockefeller Foun­ dation. It is one of the oldest hospitals in China. Dr. Mcfarlin (I) discusses his wo rk on immune During their 3-day stay, the visitors partici­ system reactio ns in MS with Dr. Zhao. pated in neLirology grand rounds at the neurology last year when, on behalf of the Clinical Center and met with scientists work­ World Health O rganization, he visi ted the ing in a va riety of neurological research areas. neuro logical and neurosurgical ,ervices of Their stops included the NINCDS Neuro­ eight major hospitals and medical school, in immuno logy Branch, where investigators are Beijing, Tianjin, and Shanghai. studying immune system reactions in multiple sclerosis, and the Laboratory of Cen tra l Nervous System Studies, where a team Used Photo Negatives heac!ed by Nobel Laureate D r. D. Carleton Can Save NIH Money Gajdusek is searching for a possible virus cause for M S. There's hidden va lue in old photo negatives! National Multiple Sclerosis Soc.iety officials The NIH Property Utilization Section is point out that China is a baffling exception to looking for all types of used photo neg,llives most multiple sclerosis "rules." The country's (including those used in printing and repro­ huge population and its location in a tem­ duction) to recover their silver content. perate zone above the 40th paral lel (the According to Joan Carter, who manages Dr. Robert Chanock, chief of the laboratory of geographical area in which multiple sclerosis the recovery operations, conservation efforts Infectious Diseases, NtAID, has recently been is most commonly found) would suggest a are being strongly emphasized because used elected a foreign member of the Royal Danish large prevalence of the •disorder. Yet in Chi na. film nets the Government $3 to $4 for each Academy o f Sciences and l etters- one of the multiple sclerosis is relatively rare. pound recovered. oldest in the wo rld- founded in 1742. An interna­ tionally recognized expe rt in the field of infectious To find out why, the society hopes to send Negatives should be forwarded to Bldg. 13, diseases, and in particular influenza, Dr. Chanock a team of American investigators to China in Rm. 2E-67. Recovery operations will arrange has been with the Institute since 1957. 1981, as a step toward U.S.-Chinese collabo­ transportation for large quantities. Small rative studies on multiple sclerosis. quantities may be sent by interoffice messen­ Dr. Donald B. Tower, NINCDS Director, ger. for additional information or pick up, took a step into the world of Chinese call 496-4257. □ ~ U.S. GOVERNMENT PRI NT ING OFFIC E: 1980-31 1-203/24

Page 12 The NIH Record August 5, 1980