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M Ademecu Um LANDES LANDES BIOSCIENCE V a d e m e c u m BIOSCIENCE V a d e m e c u m Table of contents (excerpt) Dermatopathology 1. Hyperkeratosis 9. Infiltrates by Plasma Cells, Mast and Parakeratosis Cells and Histiocytes 2. Acanthosis 10. Granulomas 3. Papillomatosis, Atrophy 11. Dermal Necrosis and Alterations of the Granular and Transepidermal Elimination Layer 12. Purpuras, Vasculitis, Emboli 4. Spongiosis, Exocytosis and Thrombi and Acantholysis 13. Dermal Deposits, Collagen 5. Vesicles and Bullae Abnormalities and Calcifications 6. Interface, Poikilodermatous 14. Panniculitis, Inclusions, Fungi Dermatitis and Necrosis and Parasites of Keratinocytes 15. Hair Follicle Abnormalities 7. Lichenoid Dermatitis, Pigmentary Incontinence and Perivascular 16. Cysts, Polyps and Hamartomas Infiltrates 17. Tumors of the Epidermis 8. Infiltrates by Lymphocytes, and of the Hair Follicles Neutrophils and Eosiniphils This is one of a new series of medical handbooks. It includes subjects generally not covered in other handbook series, especially many technology-driven topics that reflect the increasing influence of technology in clinical medicine. The name chosen for this comprehensive medical handbook series is Vademecum, a Latin word that roughly means “to carry along”. In the Middle Ages, traveling clerics carried pocket-sized books, excerpts of the carefully transcribed canons, known as Vademecum. In the 19th century a medical publisher in Germany, Samuel Karger, called a series of portable medical books Vademecum. The Vademecum books are intended to be used both in the training of physicians and the care of patients, by medical students, medical house staff and practicing physicians. We hope you will find them a valuable resource. All titles available at ISBN 1- 57059- 496- 1 Ramón L. Sánchez www.landesbioscience.com Sharon S. Raimer 9781570 594960 vademecum Dermatopathology Ramón L. Sánchez, M.D. The University of Texas Medical Branch at Galveston Galveston, Texas, U.S.A. Sharon S. Raimer, M.D. The University of Texas Medical Branch at Galveston Galveston, Texas, U.S.A. L A N D E S B I O S C I E N C E GEORGETOWN, TEXAS U.S.A. VADEMECUM Dermatopathology LANDES BIOSCIENCE Georgetown, Texas, U.S.A. Copyright ©2001 Landes Bioscience All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Printed in the U.S.A. Please address all inquiries to the Publisher: Landes Bioscience, 810 S. Church Street, Georgetown, Texas, U.S.A. 78626 Phone: 512/ 863 7762; FAX: 512/ 863 0081 ISBN: 1-57059-496-1 Library of Congress Cataloging-in-Publication Data Dermatopathology / [edited by] Ramón Sánchez, Sharon Raimer. p.;cm.--(Vademecum) Includes index. ISBN 1-57059-496-1 1. Skin--Diseases-Handbooks, manuals, etc. I. Sanchez, Ramon L. II. Raimer, Sharon. III. Series. [DNLM: 1. Skin Diseases--pathology. WR 140 D435172 2001] RL96.D476 2001 616.5--dc21 01-042377 While the authors, editors, sponsor and publisher believe that drug selection and dosage and the specifications and usage of equipment and devices, as set forth in this book, are in accord with current recommendations and practice at the time of publication, they make no warranty, expressed or implied, with respect to material described in this book. In view of the ongoing research, equipment development, changes in governmental regulations and the rapid accumulation of information relating to the biomedical sciences, the reader is urged to carefully review and evaluate the information provided herein. Dedication To the students, residents and fellows through whom we learn so much in the process of teaching. To our families, always supportive of our endeavors. Contents 1. Hyperkeratosis and Parakeratosis ..................................... 1 Gina Harney Ichthyosis Vulgaris ...................................................................................... 1 X-Linked Ichthyosis .................................................................................... 1 Lamellar Ichthyosis ..................................................................................... 2 Palmoplantar Keratoderma ......................................................................... 3 Pachyonychia Congenita ............................................................................. 3 Flegel’s Disease (Hyperkeratosis Lenticularis Perstans) ................................. 3 Vitamin A Deficiency (Phrynoderma)......................................................... 4 Confluent Parakeratosis .............................................................................. 5 Parakeratosis: Columnar or Focal ................................................................ 8 2. Acanthosis ....................................................................... 13 Marcia Driscoll Regular Acanthosis.................................................................................... 13 Irregular Acanthosis .................................................................................. 14 Lacelike Acanthosis ................................................................................... 17 3. Papillomatosis, Atrophy and Alterations of the Granular Layer ...................................................... 20 Gayle S. Westhoven Verruca/Epidermodysplasia Verruciformis ................................................. 20 Nevus Sebaceous (Organoid Hamartoma) ................................................ 21 Linear (Verrucous) Epidermal Nevus ........................................................ 24 Acrokeratosis Verruciformis of Hopf ......................................................... 24 Degos’ Disease (Malignant Atrophic Papulosis)......................................... 26 Striae Distensae ......................................................................................... 26 Radiation Dermatitis, Late ........................................................................ 27 Bullous Congenital Ichthyosiform Erythroderma ...................................... 27 Epidermolytic Keratosis Palmaris et Plantaris ............................................ 28 Isolated and Disseminated Epidermolytic Acanthoma ............................... 28 4. Spongiosis, Exocytosis and Acantholysis ......................... 29 Ramón L. Sánchez and Sharon S. Raimer Subacute dermatitis ................................................................................... 29 Acute dermatitis ........................................................................................ 29 Oral White Sponge Nevus ........................................................................ 31 Leukoedema of the Oral Mucosa .............................................................. 31 Oral Focal Epithelial Hyperplasia .............................................................. 32 Oral Hairy Leukoplakia ............................................................................ 33 Pityriasis Lichenoides, Acuta and Chronica ............................................... 33 Actinic Reticuloid ..................................................................................... 35 Pemphigus Vulgaris ................................................................................... 35 Pemphigus Vegetans.................................................................................. 37 Pemphigus Foliaceous ............................................................................... 39 Pemphigus Erythematosus ........................................................................ 39 Paraneoplastic Pemphigus ......................................................................... 40 Familial Benign Pemphigus (Hailey-Hailey Disease) ................................. 41 Transient Acantholytic Dermatosis (Grover’s Disease) ............................... 42 Darier’s Disease (Keratosis Follicularis) ..................................................... 42 Warty Dyskeratoma .................................................................................. 44 5. Vesicles and Bullae .......................................................... 45 Ramón L. Sánchez and Sharon S. Raimer Intraepidermal Vesicles.............................................................................. 45 Hydroa Vacciniforme ................................................................................ 48 Subepidermal Blisters ................................................................................ 48 Lichen planus ........................................................................................... 57 6. Interface, Poikilodermatous Dermatitis and Necrosis of Keratinocytes ......................................... 58 Ramón L. Sánchez and Sharon S. Raimer Drug Eruption .......................................................................................... 58 Graft vs Host Disease (GVHD) ................................................................ 59 Large Plaque Parapsoriasis/Early Mycosis Fungoides ................................. 61 Systemic Lupus Erythematosus (SLE) ....................................................... 62 Bullous Lupus Erythematosus ................................................................... 64 Dermatomyositis ...................................................................................... 64 Lichen Sclerosus et Atrophicus (LS&A) .................................................... 65 Erythema Multiforme
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