Scandinavian Life Sciences Dr Rob Grundy, Head of Life Sciences.

www.ocoglobal.com Scandinavia

• Constitutes Norway, Sweden and Denmark • Population: 20.5 million • European Union Members: Denmark (1973), Sweden (1995) • Currency • Denmark: Danish krone • Sweden: Swedish krona • Norway: Norwegian krone • GDP • Denmark: $257bn • Sweden: $467.5 bn • Norway: $351.6 bn Scandinavian Life Science – Strengths and Synergies

. Particular overlapping interests/synergies with activity/strengths in Maine . MedTech – Norway, Denmark . Precision Medicine – Sweden, Denmark . Marine biotechnology - Norway

. Key areas of strength in Scandinavia . Pharmaceuticals – AZ, Novo Nordisk, LEO Pharma . MedTech – Gambro, Elektra

. Commercial world leaders in Scandinavia . AZ . Novo Nordisk . LEO Pharma

Scandinavian Life Science – Research Clusters Scandinavian Life Science – M&A activity

. Significant activity in pharma and medtech space

. Steady increase in deal number

. Steady increase in deal size Scandinavian Life Science – Recent partnerships Denmark - Highlights

. 7 science parks . Mature Pharmaceutical sector . 8 universities . NovoNordisk . 75 hospitals (4 major university hospitals) . Leo Pharma . 10,000 life science graduates annually . Lundbeck . 2,000 LS PhDs students graduating annually . Strength in MedTech . 25 CROs . Hearing aid technology . ≥ 160 core biotech companies . ≥ 180 core medtech companies . 48,000 employees in the life science industry

Denmark - Universities

. University of Copenhagen (KU) – Faculty of Health and Medical Sciences . Technical University of Denmark (DTU) . University of Southern Denmark (SDU) - Faculty of Health Sciences . Aarhus University (AU) - Faculty of Health Sciences . Aalborg University (AAU) – Faculty of Medicine Denmark – Research Centers

. Danish Center for Stem Cell Research (DanStem) . Danish National Biobank . European Spallation Source (ESS) Denmark – Industrial Players

. Pharmaceuticals . MedTech . NovoNordisk . Bang & Olufson Medicom . Lundbeck . Coloplast . Leo Pharma . Dako - An Agilent Technologies Company . Zealand Pharma . GN ReSound . Bavarian Nordic . Invacare . Neurosearch . Oticon . Genmab . Philips Healthcare . ALK-Abello . Widex . Symphogen . William Cook Europe

. Services . Taconic . Novozymes Denmark – Key Resources

Invest in Denmark – Life Sciences: http://www.investindk.com/Clusters/Life-Sciences/Biotech

Danish Biotech Report: http://www.investindk.com/Home/News%20and%20events/News/2014/~/media/Files/Sheets/L ife%20Sciences/Start%20With%20Denmark%202015_Full%20Report.ashx

Sweden- Highlights

. Significant number of life science . Mature Medtech sector focussed Universities . Gambro . Karolinska Institute . Elektra

. Mature pharma/biotech sector . Innovative healthcare systems . AZ . Swedish Orphan Biovitrum

Sweden- Universities

. Karolinska Institute . Upsaala University . Stockholm University . Umeå University . Lund University . University of Gothenburg . Linköping University

Sweden– Research Centers

. Chemical Biology Consortium Sweden . Umeå Centre for Microbial Research . Umeå Plant Science Centre Sweden– Industrial Players

Pharma/biotech MedTech . Astra Zeneca . Getinge . Medivir . Gambro . Swedish Orphan Biovitrum . Elekta . Medivir . Mölnlycke Health care . Orexo . Nobel Biocare . Camurus . Permobil . Moberg Pharma . Etac . Affibody Medical . Sectra . Bioarctic Neuroscience . Atos Medical . BioInvent Bioscience . Human Care . Alligator Bioscience . InDex Pharmaceuticals

Sweden– Key Resources

. Swedish Life Sciences Industry Guide: http://www.swedishlifesciences.se/ . Swedish Drug Development Pipeline: http://swedenbio.se/wp- content/uploads/2015/12/The-Swedish-Drug-Development-Pipeline-2015.pdf . Business Sweden Life Sciences Sector: http://www.business- sweden.se/en/Invest/industries/life-science/

Norway- Highlights

. Oslo Cancer Cluster has global reputation for clinical trial opportunities

. Progressive patient record system aids recruitment

. Numerous research centres provide clear focus

. Strength in imaging

. Strength in marine science - SINTEF Norway- Universities

. Norwegian University of Life Sciences . University of Oslo . University of Bergen . Norwegian University of Science and Technology . University of Tromso Norway – Research Centres

. Oslo Cancer Cluster . Centre for Molecular Biology and Neuroscience . The Kavli Centre of Systems Neuroscience and The Centre of Biology of Memory . Medical Imaging Laboratory for Innovative Future Healthcare . The Intervention Centre at Oslo University Hospital . “Operating Rooms of the Future” project at St.Olav’s University Hospital in Trondheim . SINTEF . HUNT Biosciences Norway – Industrial Players

. GE Imaging . Lytix Cancer and Infection . BerGenBio Target Identification & Small Molecules . IsentioRipSeq Sequencing Technologies . PCI Biotech Drug Delivery . Affitech Antibody discovery platform . DiaGenic Alzheimer's diagnostic . Photocure Diagnostics & Small Molecules . Bionor Labs Aquaculture, HIV . Biotec Pharmacon Immune modulating compounds for the human health sectors and marine enzymes used in molecular biology . Biosergen Antifungals Norway – Key Resources

Oslo Cancer Cluster: http://oslocancercluster.no/ Industrial Biotech Network – Norway: http://indbiotech.no/ Oslo Medtech: http://www.oslomedtech.no/ Medicon Valley

Medicon Valley

. 7 large R&D based pharma companies with local roots . App.150 biotechs with own R&D . App. 200 medtech companies . More than 50 CROs and CMOs . 33 hospitals (of which 11 are university hospitals) . 44.000 life-science employees in the private sector . 9 science parks . 5 life science universities . More than a dozen VCs with experienced life science teams Focus on Precision Medicine/Diagnostics

. Denmark home to Dako – an Agilent Company – world leading personalised medicine

reagents, software and device supply company

. Several innovating pharma and biotech companies – a rich source of custom for the

diagnostics supply chain

. Significant imaging activity in Norway and Denmark

Focus on Medical Products

. Denmark is the second largest Medical Device market in Europe and by employment

per capita the second largest in Europe

. A large share of Danish medical devices imports is incorporated into domestic

production and subsequently re-exported as finished products – these imports tripled

between 2001 – 2011

. Norway – a medical imaging centre of excellence

Servicing the Market

. Routes to collaborating . Events: BIO Europe – Stockholm, April 4 – 6, 2016 . Swedish American Chamber of Commerce http://www.sacc-usa.org/ . Stockholm chamber of commerce http://english.chamber.se/

. Distribution networks: Swedish distributer directory can be found at www.swedishlifesciences.se  E.g. Christian Berner, distributer of IDEXX diagnostic kits

USA Pharma Exports into Norway (2014)

Norway's imports from United States of America

Product Label Share in Norway's Value in 2014, USD thousand Annual growth in value between 2010-2014, %, p.a. imports, %

Medicament mixtures (not 3002, 3005, 3006), put in dosage 156183 11 10.2

Human & animal blood; antisera, vaccines, toxins, micro-organism culture 14070 -6 3.4

Pharmaceutical goods, specified sterile products sutures, laminaria 10850 9 13.1 Dressings packaged for medical use 3985 -1 8.5

Medicament mixtures (not 3002, 3005, 3006) not in dosage 1300 12 13.7

Glands & extracts, secretions for organotherapeutic uses; heparin & it 350 33 61.2

Trademap.org USA Pharma Exports into Sweden (2014)

Sweden's imports from United States of America Product Label Annual growth in value between 2010-2014, %, Value in 2014, USD thousand Share in Sweden's imports, % p.a.

Medicament mixtures (not 3002, 3005, 3006), put in dosage 107493 21 3.6 Human & animal blood; antisera, vaccines, toxins, micro- organism culture 101696 11 10.6 Glands & extracts, secretions for organotherapeutic uses; heparin & it 95343 -7 96.3 Pharmaceutical goods, specified sterile products sutures, laminaria 1971 -3 1.5 Dressings packaged for medical use 1170 -23 0.9

Medicament mixtures (not 3002, 3005, 3006) not in dosage 39 -66 0.2

Trademap.org USA Pharma Exports into Denmark (2014)

Denmark's imports from United States of America Product Label Annual growth in value between Value in 2014, USD thousand Share in Denmark's imports, % 2010-2014, %, p.a.

Human & animal blood; antisera, vaccines, toxins, micro-organism culture 43775 10 5.6

Medicament mixtures (not 3002, 3005, 3006), put in dosage 31826 -12 1

Medicament mixtures (not 3002, 3005, 3006) not in dosage 10587 6 8

Glands & extracts, secretions for organotherapeutic uses; heparin & it 3397 -6 7.8 Dressings packaged for medical use 1900 7 1.7

Pharmaceutical goods, specified sterile products sutures, laminaria 1612 10 1.5

Trademap.org Case Study 1: PRA International

PRA International, a clinical research organisation, based in Raleigh, North Carolina.

. It specialises in oncology, respiratory/allergy, cardiovascular, and infectious diseases.

. In June 2011 US-based clinical research firm PRA International opened a new office in Lund, Sweden. The new branch provides quality clinical services across the region and allow the company to support growth of its business in Scandinavia. It is the company's first office in the country.

Motives cited: Industry Cluster / Critical Mass, Universities or researchers The Swedish office is located in the thriving region of Öresund, a hub for life science businesses. Öresund is centrally situated in the Medicon Valley, widely known as one of Europe’s primary centres for biotech and pharmaceutical activity. The region is also home to several top universities, providing access to leading academic research.

fDi Markets Case Study 2: Sapheneia

Sapheneia, a medical software company based in Dillon, Colorado.

. Sapheneia, set up a base in Linköping to carry out research and development in medical technology. . The R&D centre will initially employed 5 people, but there were 10 members of staff by the end of 2006.

Motives cited: Universities or researchers Sapheneia, which has developed a technique for removing hard-to-reach tumours, says it is setting up at the Mjärdevi Science Park to take advantage of Linköping’s research environment. “We want to be close to the specialist competence in image manipulation and visualization present in the region, particularly at Linköping University,” said Hans Grahn, Vice President of International Growth & Development at Sapheneia.

fDi Markets Concluding Thoughts

. Numerous pharma and biotech players with which to engage for the provision of precision medicine solutions

. Innovative healthcare systems where evidence based value is easily adopted

. Many med tech providers looking for OEM componentry

. A region committed to the life sciences www.ocoglobal.com