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Sa Jan 2021.Pdf SMALL ANIMAL I CONTINUING EDUCATION Canine and feline parasite control – too much choice? Sue Paterson MA VetMB DVD DipECVD FRCVS, RCVS and European Specialist in Veterinary Dermatology, and veterinary director, Virtual Vet Derms Ltd, discusses the most important ectoparasitic conditions in primary care veterinary practice and considers the different products available for treatment INTRODUCTION to have contributed to the worrying decline in populations of Routine ectoparasite control forms an important part of any small invertebrates in river systems), are due to their topical health protocol for dogs and cats and is essential as part of use on pets. However, there have been calls for research to the investigation and management of pruritic skin disease. be undertaken to investigate the potential direct and indirect In order to be able to select a suitable ectoparasiticide, it is environmental exposure pathways for dog parasiticide important that the veterinary surgeon has an appreciation of products in relation to the eect of veterinary use on levels of the mode of action of the plethora of dierent products that are neonicotinoids in the environment. available and their spectrum of activity. This review will briefly discuss the most important ectoparasitic conditions in primary ECTOPARASITE CONTROL care veterinary practice (in the UK) and consider the dierent Fleas (Ctenocephalides felis) products available for treatment. This will include their current The most common species of flea encountered on dogs and licensed indications plus any evidence around their suitability cats in the UK is Ctenocephalides felis. All animals will react for therapy of fleas, ticks, harvest mites, lice, Cheyletiella spp. to flea bites but where individuals are not sensitised to flea Sarcoptes scabiei, and Demodex spp. in the dog and cat. bites, the irritation is generally transient and does not lead to Over the last 12 months there have been changes in clinical signs. Where dogs are hypersensitive to flea salivary ectoparasiticide availability. Several products have switched antigens injected intradermally during flea feeding, they will distributors, a few such as spinosad have been discontinued, develop much more severe and widespread clinical signs. and drugs such as the neonicotinoids, although still available for Dogs with flea allergic dermatitis (FAD) develop signs of use in small animals, has been banned in farming. There is, at pruritic skin disease principally aecting the caudo-dorsal this present time, no hard evidence to suggest that chemicals lumbosacral area and often with extension of signs onto like fipronil and imidocloprid in water sources (that are thought the dorsal tail head, caudomedial thighs, abdomen and 38 Veterinary Ireland Journal I Volume 11 Number 1 Vet January 21.indd 38 23/12/2020 15:01 CONTINUING EDUCATION I SMALL ANIMAL flanks. Lesions include pruritic, papular, crusting eruptions relies on them being identified at an early stage, which with secondary erythema and self-inflicted trauma. In cats, is not always possible in a dog or cat with a thick pelage flea bite hypersensitivity is the most common cause of and, therefore, prophylactic therapy as part of a holistic pruritic skin disease and presents in a myriad of dierent ectoparasite programme is preferable. Many of the earliest ways including miliary dermatitis, self-inflicted alopecia or tick treatments such as fipronil, avermectin (selamectin), as part of the eosinophilic granuloma complex. In addition milbemycin (moxidectin) and pyrethroid derivatives to causing skin disease C. felis has been shown to act as a (permethrin, deltamethrin, flumethrin) are still available and vector for numerous pathogens including Rickettsia spp., are useful against ticks in dogs. Although many are also Bartonella spp., Mycoplasma spp. and the intermediate host licensed for cats, including flumethrin as a component of of the cestode Dipylidium caninum.1 a flea and tick collar, other pyrethrin and pyrethroids are In the last 20 years, a wide range of insecticides have been toxic in this species and are best avoided. Drugs such as registered as flea products either as mono or combined the isoxazolines represent newer licensed products with therapies. Most of the actives such as fipronil, imidacloprid, excellent tick activity. lufenuron, methoprene, permethrin and pyriproxyfen registered prior to 1997 are still available and, despite Harvest mites (Neotrombicula autumnalis) anecdotal reports suggesting otherwise, resistance to The parasitic larva of the harvest mite (Neotrombicula these products is uncommon. According to the Arthropod autumnalis) is responsible for causing an irritating pruritic Pesticide Resistance database there have, to date, only been eruption on ground-skin contact areas in dogs, it can also be reports of C. felis resistance to organochlorines, carbamates, found around the ears of outdoor cats. The larva is usually organophosphates, pyrethroids and pyrethrin. Drugs picked up by the pet while out for a rural walk or while out such as fipronil and imidacloprid have been rejuvenated hunting in the autumn. Little is licensed to treat harvest by being released as generics; other have benefited from mite infestations and although many products have good changes in formulation, application technology and by being eicacy against the parasitic larvae, few produce prolonged combined with other actives.2 Most insecticides licensed for residual protection. This means during high-risk periods veterinary use are available as prescription-only medication animals can become quickly re-infested once they return to – veterinarian (POM-V) products. Drugs such as mono a contaminated environment. Selamectin has been shown formulations of imidacloprid and fipronil are available without to be useful for therapy of harvest mites in dogs and cats. 3 veterinary prescription (as non-food producing animal – Fipronil, in a combination product with permethrin4 has veterinarian, pharmacist, SQP [NFA-VPS]). been used in dogs. Anecdotally, the author’s preference While a high degree of eicacy and persistence is essential for prevention and treatment of harvest mites is the oral for any flea product, the speed of kill (SOK) is also important isoxazolines. Although not licensed for use, they do seem to reduce feeding time which is important in animals with protect against and reduce re-infestation. flea-bite hypersensitivity. Lice (Trichodectes canis, Linognathus setosus) Ticks (Ixodidae spp.) Lice are highly host-specific parasites. The two species Both hard (Ixodidae) and soft (Argasidae) ticks occur in the found on dogs in the UK are the biting louse, Trichodectes UK but it is the hard ticks Ixodes spp. (ricinus, hexagonus, canis and the sucking louse Linognathus setosus. Feline lice canisuga) that principally aect dogs, cats are rarely infested. infestations are rare but when they occur are caused by Dermacentor reticulatus and Haemaphysalis punctata are the biting louse Felicola subrostratus. Lice infestations are also occasionally found. Ticks tend to attach to a non- uncommon in the UK and when they occur, animals may haired, thin-skinned area such as around the face. As blood be asymptomatic or highly pruritic leading to marked signs feeders the feeding activity of numerous ticks can lead to of self-inflicted trauma. Products that are licensed for the anaemia but commonly it is the wound created by the tick treatment of flea infestations can be used in the treatment bite that leads to local irritation particularly if the tick is of lice. Selamectin, fipronil and imidocloprid are specifically removed after it has attached and the mouth warts are left licensed for the treatment of biting lice, although isoxazolines in the skin. With the increase of reports in the veterinary should also be useful. literature of tick-borne disease in the UK over the last few years, tick control has become a much more important part Browsing mite (Cheyletiella spp.) of routine ectoparasite control. Ticks are known to carry a Cheyletiella spp. is a browsing mite that feeds on the surface of range of bacterial, rickettsial, viral and protozoal diseases. the skin leading to mild pruritic dermatitis, usually manifesting The most common tick-borne disease in the UK is Lyme a dorsal scaling with erythema and crust. Cheyletiella yasguri disease (Borrelia burgdorferi) transmitted by Ixodes ticks, is the species often found on dogs, and Cheyletiella blakei on however babesiosis (Babesia canis) has been recognised cats. However, the mite is not host specific and Cheyletiella very recently _ in June 2020 _ (MRCVS Online) in the parasitovorax may also be identified on pets. Few products are south of England in dogs with no history of travel abroad. licensed for the treatment of Cheyletiella, so flea products with The babesia parasite was thought to be transferred by D. acaricidal activity in the form of sprays, spot-ons or oral drugs reticulatus ticks. While ticks can be manually removed, this are therefore usually employed. Selamectin, moxidectin and Veterinary Ireland Journal I Volume 11 Number 1 39 Vet January 21.indd 39 23/12/2020 15:01 SMALL ANIMAL I CONTINUING EDUCATION Table 1: Products available for the prevention and treatment of ectoparasites in dogs. Mode of action Examples Canine formulation Age and Ectoparasite spectrum of minimum weight activity Chloride channel activators Selamectin (A) Spot-on treatment Dogs >6 weeks Licensed for fleas, ear Dogs <2.5kg mites, Sarcoptes scabiei, Trichodectes canis
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