Bioterrorism and the NCCAM the Selling of 'Complementary and Alternative Medicine'
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Complaint Counsel's Opposition to Renewed Motion to Quash
FEDERAL TRADE COMMISSION | OFFICE OF THE SECRETARY | FILED 4/14/2021 | OSCAR NO. 601202PUBLIC | PUBLIC UNITED STATES OF AMERICA BEFORE THE FEDERAL TRADE COMMISSION OFFICE OF ADMINISTRATIVE LAW JUDGES ________________________________________________ In the Matter of HEALTH RESEARCH LABORATORIES, LLC, a limited liability company, WHOLE BODY SUPPLEMENTS, LLC, a limited liability company, and DOCKET NO. 9397 KRAMER DUHON, individually and as an officer of HEALTH RESEARCH LABORATORIES, LLC and WHOLE BODY SUPPLEMENTS, LLC. ______________________________________________ COMPLAINT COUNSEL’S OPPOSITION TO RENEWED MOTION TO QUASH Respondents have made their prior counsel, Olshan Frome Wolosky LLP (“Olshan”), central to this matter by blaming consultants engaged at Olshan’s suggestion for Respondents’ admittedly unlawful advertising. Consequently, what those consultants told Respondents before they chose to run their deceptive advertising is crucial to determining the appropriate scope of relief. Yet Respondents refuse to produce their consultants’ work, and their consultants dubiously claim they no longer possess it. As a result, Complaint Counsel had no choice but to seek this important nonprivileged material from Olshan directly. Respondents claim attorney-client privilege, but their blanket assertion that everything Olshan may possess is allegedly “confidential” does not meet their burden. To prove consulting materials are privileged, Respondents must establish that the consultants worked exclusively to help Olshan provide legal advice, or that they are the “functional equivalent” of Respondents’ own employees. Here, neither is true. Accordingly, because Olshan possesses relevant, nonprivileged documents not available elsewhere, Respondents’ motion must be denied.1 1 Complaint Counsel’s March 30 motion to reschedule the evidentiary hearing to permit more time for discovery is pending before the Commission. -
Timothy Ferris Or James Oberg on 1 David Thomas on Eries
The Bible Code II • The James Ossuary Controversy • Jack the Ripper: Case Closed? The Importance of Missing Information Acupuncture, Magic, i and Make-Believe Walt Whitman: When Science and Mysticism Collide Timothy Ferris or eries 'Taken' James Oberg on 1 fight' Myth David Thomas on oking Gun' Published by the Comm >f Claims of the Paranormal THE COMMITTEE FOR THE SCIENTIFIC INVESTIGATION off Claims of the Paranormal AT THE CENTER FOR INQUIRY-INTERNATIONAl (ADJACENT TO THE STATE UNIVERSITY OF NEW YORK AT BUFFALO) • AN INTERNATIONAL ORGANIZATION Paul Kurtz, Chairman; professor emeritus of philosophy. State University of New York at Buffalo Barry Karr, Executive Director Joe Nickell, Senior Research Fellow Massimo Polidoro, Research Fellow Richard Wiseman, Research Fellow Lee Nisbet Special Projects Director FELLOWS James E. Alcock,* psychologist, York Univ., Susan Haack, Cooper Senior Scholar in Arts and Loren Pankratz, psychologist Oregon Health Toronto Sciences, prof, of philosophy, University of Miami Sciences Univ. Jerry Andrus, magician and inventor, Albany, C. E. M. Hansel, psychologist, Univ. of Wales John Paulos, mathematician, Temple Univ. Oregon Al Hibbs. scientist Jet Propulsion Laboratory Steven Pinker, cognitive scientist, MIT Marcia Angell, M.D., former editor-in-chief, New Douglas Hofstadter, professor of human Massimo Polidoro, science writer, author, execu England Journal of Medicine understanding and cognitive science, tive director CICAP, Italy Robert A. Baker, psychologist, Univ. of Kentucky Indiana Univ Milton Rosenberg, psychologist, Univ. of Stephen Barrett, M.D., psychiatrist, author, Gerald Holton, Mallinckrodt Professor of Physics Chicago consumer advocate. Allentown, Pa. and professor of history of science. Harvard Wallace Sampson, M.D., clinical professor of Barry Beyerstein.* biopsychologist. -
OMED 17 PHILADELPHIA, PENNSYLVANIA 29.5 Category 1-A CME Credits Anticipated
® OCTOBER 7 - 10 OMED 17 PHILADELPHIA, PENNSYLVANIA 29.5 Category 1-A CME credits anticipated ACOFP / AOA’s 122nd Annual Osteopathic Medical Conference & Exposition Joint Session with ACOFP and Cleveland Clinic: Managing Chronic Disease Herpes Zoster: Diagnosis, Treatment and Prevention Leonard Calabrese, DO The American College of Osteopathic Family Physicians is accredited by the American Osteopathic Association Council to sponsor continuing medical education for osteopathic physicians. The American College of Osteopathic Family Physicians designates the lectures and workshops for Category 1-A credits on an hour-for-hour basis, pending approval by the AOA CCME, ACOFP is not responsible for the content. 10/5/2017 Herpes Zoster: Diagnosis, Treatment and Prevention Leonard Calabrese Professor of Medicine Cleveland Clinic Lerner College of Medicine 1 10/5/2017 Herpes Zoster: Diagnosis, Treatment and Prevention • Biology & Epidemiology • Clinical Aspects • Treatment and prevention Varicella Zoster Virus • Family: herpesviridae • Subfamily: alpha herpesviridae • Ubiquitous • 99+% of adults have immunologic memory • Transmission: airborne; via fomites from skin lesions • 2 clinical forms: - Varicella (primary) - Herpes zoster (reactivation) 2 10/5/2017 History • Molecular link between VZV and HZ first demonstrated by Stephen Straus (NEJM 1984) • Latency in dorsal root ganglia molecularly demonstrated by Donald Gilden (NEJM 1990) Straus SE., et al. Endonuclease analysis of viral DNA from varicella and subsequent zoster infections in the same -
April 30, 1991, NIH Record, Vol. XLIII, No. 9
April 30, 1991 Vol. XLHI No. 9 "Still U.S. Deparcmenc of Health The Second and Human Set-vices Best Thing About Payday" Natiorud lnstirures of Heahh e Recori New Recommendations on Cholesterol and Children Released A ll healthy children above the age of 2 should eat in a heart-healthy way to lower blood cholesterol and help prevent coronary heart disease in adulthood, according to new recommendations released by che National Cholesterol Education Program, which is sponsored by the National Heare, Lung, and Blood Institute. The recommendations emphasize lowering the average blood cholesterol of all American children and adolescents through population wide changes in earing patterns. "Our review of the· scientific evidence has convinced us that atherosclerosis begins in childhood and that chis process is related to nutrition practices which affect blood cho lesterol levels both in children and in adu.lcs," said Dr. Claude Lenfanc, NHLBI direcror. "Coronary heart disease is the leading cause of death in che United Scates," he added. "If we could delay the onset of heart disease, we could extend che years of healchy life for many Americans." The new recommendations are contained in NHLBJ director Dt·. Cla11.de Lenfant Jpeak.J at the National Cholesterol Education Program prm conference a report written by a panel of experts con Apr. 8 at the Sheraton WaJhington Hotel. The program recommendJ fqwering the average blood choleJtet•ol vened by the instirute's National Cholesterol level of all Americ,m children ove,· age 2 . (See CHOL£ST£ROL, Page 4 ) Immunologist Max D. Cooper Gene Blocks Cancer Spread To Deliver 1991 Dyer Lecture In Mice, Say NCI Scientists By Elaine Blume l ncernacionally renowned immunologist Dr. -
Dual Recognition of Herpes Simplex Viruses by TLR2 and TLR9 in Dendritic Cells
Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells Ayuko Sato†, Melissa M. Linehan, and Akiko Iwasaki‡ Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520 Edited by Richard A. Flavell, Yale University School of Medicine, New Haven, CT, and approved September 27, 2006 (received for review June 18, 2006) Dendritic cells (DCs) express multiple Toll-like receptors (TLR) in and suppression of viral replication depended mostly on IRF7 and distinct cellular locations. Herpes simplex viruses (HSV) have been to a much lesser extent on MyD88 (6). reported to engage both the surface TLR2 and intracellular TLR9 in Although these three distinct pathways of herpesvirus recogni- conventional DCs. However, the contributions of these TLRs in tion are known to exist, the relative contributions of these pathways recognition of HSV and the induction of proinflammatory cyto- in viral recognition vs. viral pathogenesis are unclear. The ability of kines in DCs remain unclear. Here, we demonstrate that a rare HSV-1 to trigger TLR2 has been shown to be responsible for the population of HSV, both in laboratory strains and in primary clinical exacerbation of neonatal herpes encephalitis (13), because neonatal isolates from humans, has the capacity to activate TLR2. This virus mice deficient in TLR2 secreted less IL-6 and had a higher rate of population is recognized through both TLR2 and TLR9 for the survival compared with WT mice upon lethal HSV-1 challenge. induction of IL-6 and IL-12 secretion from bone marrow-derived Further, the ability of HSV-1 and HSV-2 to activate TLR2 has been DCs. -
Varicella-Zoster Virus ORF57, Unlike Its Pseudorabies Virus UL3.5 Homolog, Is Dispensable for Viral Replication in Cell Culture
VIROLOGY 250, 205±209 (1998) ARTICLE NO. VY989349 Varicella-Zoster Virus ORF57, Unlike Its Pseudorabies Virus UL3.5 Homolog, Is Dispensable for Viral Replication in Cell Culture Edward Cox,1 Sanjay Reddy,1 Ilya Iofin, and Jeffrey I. Cohen2 Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 Received May 27, 1998; returned to author for revision June 24, 1998; accepted July 23, 1998 Varicella zoster virus (VZV) encodes five genes that do not have homologs in herpes simplex virus. One of these genes, VZV ORF57, is predicted to encode a protein containing 71 amino acids. Antibody to ORF57 protein immunoprecipitated a 6-kDa protein in the cytosol of VZV-infected cells. Although the homolog of VZV ORF57 in pseudorabies virus, UL3.5, is critical for viral egress and growth in cell culture, VZV unable to express ORF57 replicated to titers similar to those seen with parental virus. Thus VZV ORF57 has a different role in viral replication than its pseudorabies virus homolog. INTRODUCTION itis virus UL3.5 to 220 amino acids for PRV UL3.5. These proteins have sequence homology in their first 50 amino Varicella-zoster virus (VZV) is a member of the alpha- acids (Khattar et al., 1995) and contain a large number of herpesvirus subfamily. This subfamily is further divided basic amino acids with isoelectric points ranging from 10 into the genus Simplexvirus, which includes herpes sim- to 13. BHV-1 UL3.5 is a virion protein associated with the plex virus (HSV) and herpesvirus simiae, and Varicello- tegument or envelope whose role in virus replication is virus, which includes VZV, equine herpesvirus type 1 unknown (Schikora et al., 1998). -
Hope Through Research
Hope Through Research Shingles Prepared by: Office of Communications and Public Liaison National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda, Maryland 20892-2540 National Institute of Neurological Disorders NIH Publication No. 11-307 and Stroke July 2011 National Institutes of Health Cover illustration: Cultured human skin cells infected with varicella zoster virus, stained with acridine orange and photographed under ultraviolet light. Courtesy of Dr. Randall Cohrs, University of Colorado Health Sciences Center. This pamphlet was written and published by the National Institute of Neurological Disorders and Stroke (NINDS), the United States’ leading sup- porter of research on disorders of the brain and nerves, including shingles. NINDS, one of the U.S. Government’s National Institutes of Health in Bethesda, Maryland, is part of the Public Health Service within the U.S. Department of Health and Human Services. Table of Contents Page Introduction ............................................. 1 What is Shingles? ....................................... 2 Who is at Risk for Shingles? .......................... 3 What are the Symptoms of Shingles? ............... 4 How Should Shingles Be Treated? .................. 6 Is Shingles Contagious? ............................... 7 Can Shingles Be Prevented? .......................... 7 Chickenpox vaccine ............................... 7 Shingles vaccine .................................... 8 What is Postherpetic Neuralgia? .................... 9 Postherpetic -
Nectin-2-Mediated Entry of a Syncytial Strain of Herpes Simplex Virus Via
Virology Journal BioMed Central Research Open Access Nectin-2-mediated entry of a syncytial strain of herpes simplex virus via pH-independent fusion with the plasma membrane of Chinese hamster ovary cells Mark G Delboy, Jennifer L Patterson, Aimee M Hollander and Anthony V Nicola* Address: Department of Microbiology and Immunology, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia, 23298-0678, USA Email: Mark G Delboy - [email protected]; Jennifer L Patterson - [email protected]; Aimee M Hollander - [email protected]; Anthony V Nicola* - [email protected] * Corresponding author Published: 27 December 2006 Received: 16 October 2006 Accepted: 27 December 2006 Virology Journal 2006, 3:105 doi:10.1186/1743-422X-3-105 This article is available from: http://www.virologyj.com/content/3/1/105 © 2006 Delboy et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Herpes simplex virus (HSV) can utilize multiple pathways to enter host cells. The factors that determine which route is taken are not clear. Chinese hamster ovary (CHO) cells that express glycoprotein D (gD)-binding receptors are model cells that support a pH-dependent, endocytic entry pathway for all HSV strains tested to date. Fusion-from-without (FFWO) is the induction of target cell fusion by addition of intact virions to cell monolayers in the absence of viral protein expression. The receptor requirements for HSV-induced FFWO are not known. -
Identification and Characterization of Low Ph-Triggered Conformational Changes in the Herpes Simplex Virus Glycoprotein B
Virginia Commonwealth University VCU Scholars Compass Theses and Dissertations Graduate School 2011 Identification and characterization of low pH-triggered conformational changes in the herpes simplex virus glycoprotein B Stephen Dollery Virginia Commonwealth University Follow this and additional works at: https://scholarscompass.vcu.edu/etd Part of the Medicine and Health Sciences Commons © The Author Downloaded from https://scholarscompass.vcu.edu/etd/176 This Dissertation is brought to you for free and open access by the Graduate School at VCU Scholars Compass. It has been accepted for inclusion in Theses and Dissertations by an authorized administrator of VCU Scholars Compass. For more information, please contact [email protected]. Identification and characterization of low pH-triggered conformational changes in the herpes simplex virus glycoprotein B A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. March 31st, 2011 By Stephen J. Dollery B.Sc., (Hons) Human Biosciences, Sheffield Hallam University, Sheffield, UK, 2003 Director: Anthony Nicola Ph.D. Associate Professor, Department of Microbiology and Immunology Acknowledgements: I am indebted to my mentor Anthony Nicola, who gave freedom, guidance and the opportunity to study in such an exceptional world-class lab. I am also sincerely grateful to Michael McVoy for his mentoring, encouragement and kindness. I would like to thank Mark Delboy, Abena Watson-Siriboe, Carlos Siekavizza-Robles, Kayla Pfab, Frances Saccoccio, Devin Roller and James Doyle for their help and advice in the lab. I would also like to thank Jianben Wang, Xiaohong Cui, Anne Sauer, Megan Crumpler, Alison Kuchta and Frances White for their help in training me. -
Dawkins, Collins, and the Science-Religion Debate: a New Sociological Study
[ NEWS AND COMMENT Dawkins, Collins, and the Science-Religion Debate: A New Sociological Study DECLAN FAHY A new study appears to dent zoologist Richard Dawkins’s influence as a pub- lic intellectual, arguing that he does not persuade new readers that science and religion are in conflict. But the researchers concluded that biologist Francis Collins, director of the National Institutes of Health and an evangelical Christian, could persuade audiences that science and faith can be compatible. The sociological study, published in Public Understanding of Science, sur- veyed 10,000 Americans to assess in part how scientists who write popular Zoologist and prominent atheist Richard Dawkins (left) and Francis Collins, director of the National books influence public views of reli- Institutes of Health and an evangelical Christian. gion. It identified citizens’ views about the relationship between science and nent stars. In the second, as scholars of religion and tested whether these views Dawkins, in effect, religion have long recognized, atheists changed after learning about Dawkins, gave atheism a have attracted significant personal and author of The God Delusion, and Col- social stigma and have been granted a lins, author of The Language of God: A place in public life. limited space in U.S. public life. Scientist Presents Evidence for Belief. Dawkins had earned cultural promi- The study, funded by the philan- nence and a devoted following since the thropic John Templeton Foundation, lead author, said public attitudes to- 1976 publication of The Selfish Gene, which promotes dialogue between ward atheists could explain why Col- but with the 2006 publication of The science and religion, found that more lins had more power than Dawkins to God Delusion he became the embodi- than 21 percent of citizens had heard of sway opinions. -
Varicella-Zoster Virus ORF61 Deletion Mutants Replicate in Cell Culture, but a Mutant with Stop Codons in ORF61 Reverts to Wild-Type Virus
VIROLOGY 246, 306±316 (1998) ARTICLE NO. VY989198 View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Varicella-Zoster Virus ORF61 Deletion Mutants Replicate in Cell Culture, but a Mutant with Stop Codons in ORF61 Reverts to Wild-Type Virus Jeffrey I. Cohen1 and Hanh Nguyen Medical Virology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892 Received January 26, 1998; returned to author for revision February 24, 1998; accepted April 16, 1998 Varicella-zoster virus (VZV) ORF61 encodes a phosphoprotein that transactivates VZV promoters. Transfection of cells with cosmid DNAs, including a cosmid with a large deletion in ORF61, resulted in a VZV ORF61 deletion mutant that was impaired for growth in vitro and could be partially complemented by growth in neuroblastoma or osteosarcoma cell lines. Cells infected with the VZV ORF61 deletion mutant expressed normal levels of an immediate-early VZV protein, but had reduced levels of a late protein and showed abnormal syncytia. Carboxy terminal truncation mutants of VZV ORF61 protein have a transrepressing phenotype and inhibit the infectivity of cotransfected wild-type viral DNA. Transfection of cells with cosmid DNAs, including a cosmid with stop codons that should result in an ORF61 truncation mutant expressing a transrepressing protein that retains the RING finger domain, resulted in a viral genome which reverted back to the wild-type sequence. BAL-31 exonuclease was used to produce deletions at the site of the stop codons in ORF61 of the cosmid, resulting in loss of the RING finger domain. -
Another Lunar Effect Put to Rest
Another Lunar Effect Put to Rest Thirty years ago, published reports suggested that plants could grow better on lunar "soil" than they could on terrestrial soils. A series of experimental errors, reporting errors, and omissions led to this conclusion. Previously unpublished data easily explain the reported effects. HAVEN SWEET his article is long overdue. It has been written in my mind hundreds of times, only to be displaced by Tmore pressing activities. I eventually convinced myself that people had forgotten the claims made after man first landed on the Moon, claims that attributed very unusual properties to the Moon. My complacency changed while listening to one of the many twenty-fifth anniversary tributes to the first lunar landing. (Now the thirtieth anniversary has passed, in July 1999, and I can wait no longer.) I heard a former NASA offi- cial refer to the quarantine testing and indicate that there was one significant result: that plants had been shown to grow better on Moon dust than they did on Earth soil. SKEPTICAL INQUIRER November/December 1999 47 This statement thrust me back to my days with the space look at how these results came to be, and how the myth grew. program, a time when similar statements were made with lit- tle regard for the facts. At that time, the press was hungry for Background of Plant Quarantine Testing news. The excitement of the lunar landing still held the pub- As part of the trip to the Moon, NASA was required to deter- lic interest in everything dealing with space. T h e spotlight was mine if "lunar organisms" existed, and if so, whether they on NASA, and some used this opportunity to present specula- posed a threat to Earth.