Measuring Mindful Interoception : Development of the Mindful Interoception Sampling Task (MIST)

Total Page:16

File Type:pdf, Size:1020Kb

Measuring Mindful Interoception : Development of the Mindful Interoception Sampling Task (MIST) University of Louisville ThinkIR: The University of Louisville's Institutional Repository Electronic Theses and Dissertations 8-2014 Measuring mindful interoception : development of the mindful interoception sampling task (MIST). Samuel J. Dreeben University of Louisville Follow this and additional works at: https://ir.library.louisville.edu/etd Part of the Psychology Commons Recommended Citation Dreeben, Samuel J., "Measuring mindful interoception : development of the mindful interoception sampling task (MIST)." (2014). Electronic Theses and Dissertations. Paper 371. https://doi.org/10.18297/etd/371 This Doctoral Dissertation is brought to you for free and open access by ThinkIR: The nivU ersity of Louisville's Institutional Repository. It has been accepted for inclusion in Electronic Theses and Dissertations by an authorized administrator of ThinkIR: The nivU ersity of Louisville's Institutional Repository. This title appears here courtesy of the author, who has retained all other copyrights. For more information, please contact [email protected]. MEASURING MINDFUL INTEROCEPTION: DEVELOPMENT OF THE MINDFUL INTEROCEPTION SAMPLING TASK (MIST) By Samuel J. Dreeben B.A. Williams College, 2006 M.A. University of Louisville 2011 A Dissertation Submitted to the Faculty of the College of Arts and Sciences of the University of Louisville in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Department of Psychological and Brain Sciences University of Louisville Louisville, Kentucky August 2014 MEASURING MINDFUL INTEROCEPTION: DEVELOPMENT OF THE MINDFUL INTEROCEPTION SAMPLING TASK (MIST) By Samuel J. Dreeben B.A. Williams College, 2006 M.A. University of Louisville 2011 A Dissertation Approved on June 18, 2014 by the following Dissertation Committee: _________________________________ Paul Salmon, Ph.D., Dissertation Chair _________________________________ Ken Linfield, Ph.D. _________________________________ Keith Lyle, Ph.D. _________________________________ Benjamin Mast, Ph.D. _________________________________ Sandra Sephton, Ph.D. ii ABSTRACT MEASURING MINDFUL INTEROCEPTION: DEVELOPMENT OF THE MINDFUL INTEROCEPTION SAMPLING TASK (MIST) Samuel J. Dreeben June 18, 2014 Sustained, non-evaluative, present moment interoception or ―mindful interoception‖ (MI) is a central feature of many widely practiced clinical interventions, including mindfulness-based therapies, cognitive-behavioral therapies, focusing-oriented psychotherapy, and Gestalt therapy. However, to date, no valid measures of MI have been developed. The lack of such a measure has precluded attempts to discern A) to what extent MI ability changes as a function of MI-based therapies, B) if change in MI mediates symptom reduction, and C) if individual differences in MI ability are associated with anxiety, mindfulness, and other hypothetically related constructs. The purpose of the current study was to develop and validate the first such measure of MI, the Mindful Interoception Sampling Task (MIST). The MIST is a behavioral measure of MI, in which participants focus attention on sequential regions of the body and are periodically prompted to report whether their attention has wandered. Higher scores on the MIST are thus hypothetically reflective of lower levels of MI. iii One hundred eight participants were recruited from undergraduate psychology courses for this study. Participants were administered the MIST and the Schandry heartbeat detection task, a widely used behavioral measure of interoception. A battery of questionnaires was also administered, and resting heart rate and blood pressure were recorded. Results of this study indicate the MIST is a valid behavioral measure of mindfulness, the first of its kind. Further research is still needed to determine whether the MIST specifically measures MI. Current findings, however, do suggest the newly identified construct of MI is an important and promising focus of clinical research. iv TABLE OF CONTENTS Abstract ........................................................................................................................... iii List of Tables ................................................................................................................. vii Introduction ...................................................................................................................... 1 Mindfulness .......................................................................................................... 1 Interoception ........................................................................................................ 6 Mindful Interoception ........................................................................................ 11 Measuring Mindful Interoception ...................................................................... 18 The Mindful Interoception Sampling Task ........................................................ 35 Methods.......................................................................................................................... 44 Participants ......................................................................................................... 44 Procedures .......................................................................................................... 45 Measures ............................................................................................................ 46 Results ............................................................................................................................ 49 Data Overview ................................................................................................... 49 Preliminary Analyses ......................................................................................... 51 Primary Analyses ............................................................................................... 54 Supplementary Analyses .................................................................................... 63 Exploratory Analyses ......................................................................................... 66 Discussion ...................................................................................................................... 72 v Ordering Effects and Internal Consistency ........................................................ 72 Potential Covariates ........................................................................................... 73 Anxiety Sensitivity Index-3 ............................................................................... 74 Self-Report Measures of Mindfulness and MI ................................................... 76 Construct Validity of MIST Focal Regions ....................................................... 78 Variations on the MIST ..................................................................................... 81 Observations on the MAIA ................................................................................ 82 Limitations ......................................................................................................... 84 Strengths ............................................................................................................ 85 Future Directions ............................................................................................... 87 Closing Thoughts ............................................................................................... 89 References ...................................................................................................................... 90 Supplemental Tables .................................................................................................... 107 Appendices ................................................................................................................... 114 Curriculum Vita ........................................................................................................... 125 vi LIST OF TABLES TABLE PAGE 1. Facets of Mindfulness, as Identified in Definitions of Mindfulness ............................ 107 2. Mechanisms of Mindfulness, as Identified in Theoretical Papers ................................ 108 3. Completed Measures ...................................................................................................... 50 4. MIST Focal Regions, by Sequence in Script ...............................................................52 5. MIST Focal Regions, by Region of Body ....................................................................53 6. Pearson Product-Moment Correlations for Interoceptive Tasks and Potential Physiological Covariates ........................................................................................................ 54 7. Pearson Product-Moment Correlations for Interoceptive Tasks and ASI-3 Subscales .. 56 8. Semi-Partial Correlations for Interoceptive Tasks and ASI-3 Subscales ..................... 109 9. Pearson Product-Moment Correlations for Interoceptive Tasks and Selected MAIA Scales ...................................................................................................................................... 58 10. Semi-Partial Correlations for Interoceptive Tasks and Selected MAIA Scales ........... 109 11. Pearson Product-Moment Correlations for PHLMS Awareness Scale and FFMQ Act with Awareness Scale with Selected MAIA Scales ............................................................... 61 12. Hypothesized Nomological Net .....................................................................................
Recommended publications
  • Obituary Johan Schioldann
    Obituary Johan Schioldann To cite this version: Johan Schioldann. Obituary. History of Psychiatry, SAGE Publications, 2006, 17 (2), pp.247-252. 10.1177/0957154X06061602. hal-00570850 HAL Id: hal-00570850 https://hal.archives-ouvertes.fr/hal-00570850 Submitted on 1 Mar 2011 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. HPY 17(2) Schou obituary 2/5/06 09:21 Page 1 History of Psychiatry, 17(2): 247–252 Copyright © 2006 SAGE Publications (London, Thousand Oaks, CA and New Delhi) www.sagepublications.com [200606] DOI: 10.1177/0957154X06061602 Obituary Mogens Abelin Schou (1918–2005) – half a century with lithium JOHAN SCHIOLDANN* Mogens Schou, the most prominent of the pioneers of modern lithium therapy, passed away on 29 September 2005. He was 86 years old. A couple of days before, he had returned home from an IGSLI (International Group for the Study of Lithium-Treated Patients) meeting in Poland. He succumbed to pneumonia, having managed to finish a last manuscript just hours before. Schou was born in Copenhagen in 1918. His father, Hans Jacob Schou, an influential figure in Danish psychiatry, adopted the notion of a biological basis of affective disorders from his countryman, Carl Lange, one of the early era lithium pioneers (Schioldann, 2001), and established a research laboratory to study the possible biochemical and physiological changes in manic-depressive illness (Schou, 2005).
    [Show full text]
  • Feelings and the Body: the Jamesian Perspective on Autonomic Specificity of Emotion§ Bruce H
    Biological Psychology 84 (2010) 383–393 Contents lists available at ScienceDirect Biological Psychology journal homepage: www.elsevier.com/locate/biopsycho Review Feelings and the body: The Jamesian perspective on autonomic specificity of emotion§ Bruce H. Friedman * Department of Psychology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0436, United States ARTICLE INFO ABSTRACT Article history: ‘‘What is an emotion?’’ William James’s seminal paper in Mind (1884) proposed the idea that Received 27 May 2009 physiological and behavioral responses precede subjective experience in emotions that are marked by Accepted 17 October 2009 ‘‘distinct bodily expression.’’ This notion has broadly inspired the investigation of emotion-specific Available online 29 October 2009 autonomic nervous system activity, a research topic with great longevity. The trajectory of this literature is traced through its major theoretical challenges from the Cannon–Bard, activation, and Schachter– Keywords: Singer theories, through its rich empirical history in the field of psychophysiology. Although these James–Lange theory studies are marked by various findings, the overall trend of the research supports the notion of Emotion autonomic specificity for basic emotions. The construct of autonomic specificity continues to influence a Autonomic nervous system number of core theoretical issues in affective science, such as the existence of basic or ‘natural kinds’ of emotion, the structure of affective space, the cognition–emotion relationship, and the function of emotion. Moreover, James’s classic paper, which stimulated the emergence of psychology from philosophy and physiology in the latter nineteenth century, remains a dynamic force in contemporary emotion research. ß 2009 Elsevier B.V. All rights reserved.
    [Show full text]
  • History of Neurology William James MD.Pdf
    History of Neurology WILLIAM JAMES, MD FEBRUARY 6TH, 2017 NEUROLOGY RESIDENT MORNING REPORT William James MD (1842-1910) • B NYC; wealthy family, went to Europe • Brother- Henry James (author) • 1st studied art • Harvard undergrad; studied in Europe under Von Helmholtz • Harvard med school- graduated age 27 • Zoological expedition with Louis Agassiz in Brazil (Amazon) • Nervous breakdown (3 years) • On recovery epiphany: – “My first act of free will shall be to believe in free will” – Returned to life: experience/anti-mental, intellectual, Cartesian • 1872 (age 30)-taught physiology at Harvard • 1875-Began teaching psychology – Established 1st experimental psychology lab in the USA • Principles of Psychology; started in 1879, published in 1890 • 1879-began teaching philosophy • After publication of Principles James lost interest in this “nasty little subject”: “All one cares to know lies outside it” William James MD (1842-1910) “The James” • 1890 Principles of Psychology-2 volumes: the “James” • One of the “Great Books” of Western Civilization! • 1892-Psychology The Briefer Course: the “Jimmy” • 1897 The Will To Believe & Other Essays in Popular Philosophy • 1899-Talks to Teachers on Psychology: and to Students on Some of Life's Ideals • 1902- The Varieties of Religious Experience – Another religious epiphany from vacation in Adirondacks: “it seemed as if the Gods of all the of all nature- mythologies were holding an indescribable meeting in my breast with the moral “The Jimmy” Gods of the inner life” • 1907- Pragmatism: A New Name for
    [Show full text]
  • Vernon Lee's Psychological Aesthetics Carolyn Burdett Revi
    ‘The subjective inside us can turn into the objective outside’: Vernon Lee’s Psychological Aesthetics Carolyn Burdett Reviewing Vernon Lee’s Beauty and Ugliness, which appeared in 1912, the New York Times concluded that it ‘is simply a “terrible” book: Long, involved sentences, long scientific terms, queerly inverted thoughts, French words and Latin and German, all hammer at one’s cerebral properties with unquenchable vehemence’. The review, entitled ‘What is Beauty?’, quotes for illustration of its assessment a paragraph, taken ‘almost at random from the middle of the work’.1 It makes the point well enough: its technical, reference-laden sentences are bafflingly opaque to a reader unfamiliar with the largely German-authored debate about aesthetics with which Lee is engaging. Wittingly or not, however, the New York Times’s disgruntled reviewer has selected a key passage. It takes us to the heart of the debate about psychology and about aesthetics, and about the relationship between the two, which was taking place at the end of the nineteenth century. At its simplest, Lee’s objectionable paragraph concerns the question of whether aesthetic responsiveness is primarily bodily or mental, and what it means to try to make a distinction between the two. By the time she compiled Beauty and Ugliness, a collection which included work dating back to the 1890s, Lee was making use of a newly translated word, ‘empathy’. For Lee, empathy was the mechanism which explained aesthetic experience and thus a good deal about emotion as such. She saw it as
    [Show full text]
  • Is Emotion a Form of Perception?
    Is Emotion a Form of Perception? Prinz, Jesse J. Canadian Journal of Philosophy, Volume 36 (2006) Supplement [vol. 32], pp. 137-160 (Article) Published by Canadian Journal of Philosophy DOI: 10.1353/cjp.2007.0035 For additional information about this article http://muse.jhu.edu/journals/cjp/summary/v036/36.5Sprinz.html Access Provided by Simon Fraser University at 10/08/12 5:01AM GMT CANADIAN JOURNAL OF PHILOSOPHY Supplementary Volume 32 Is Emotion a Form of Perception? JESSE J. PRINZ Theories of emotions traditionally divide into two categories. According to some researchers, emotions are or essentially involve evaluative thoughts or judgments. These are called cognitive theo- ries. According to other researchers, an emotion can occur without any thought. These are called non-cognitive theories. Some defenders of non-cognitive theories argue that emotions are action tendencies, others say they are feelings, and still others say they are affect pro- grams, which encompass a range of internal and external events. One of the most celebrated non-cognitive theories owes, independently, to William James and Carl Lange. According to them, emotions are perceptions of patterned changes in the body. I think the perceptual theory of emotions is basically correct, but it needs to be updated. In this discussion, I will offer a summary and defence. The question I am addressing bears on the question of modularity. Within cognitive science, there is a widespread view that perceptual systems are modular. If this is right, then showing that emotion is a form of perception requires showing that emotion is a modular pro- cess, and showing that emotion is modular could contribute to show- ing that emotion is a form of perception (assuming that not all mental capacities are underwritten by modular systems).
    [Show full text]
  • I Interoceptive Contributions to Motivational and Affective
    Interoceptive Contributions to Motivational and Affective Modulators of Memory Formation by Courtnea Rainey Department of Psychology & Neuroscience Duke University Date:_______________________ Approved: ___________________________ R. Alison Adcock, Supervisor ___________________________ Scott Huettel ___________________________ Elizabeth Brannon ___________________________ F. Joseph McClernon Dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Psychology & Neuroscience in the Graduate School of Duke University 2015 i v ABSTRACT Interoceptive Contributions to Motivational and Affective Modulators of Memory Formation by Courtnea Rainey Department of Psychology & Neuroscience Duke University Date:_______________________ Approved: ___________________________ R. Alison Adcock, Supervisor ___________________________ Scott Huettel ___________________________ Elizabeth Brannon ___________________________ F. Joseph McClernon An abstract of a dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Psychology & Neuroscience in the Graduate School of Duke University 2015 Copyright by Courtnea Rainey 2015 Abstract Biological drives such as hunger, thirst, and sexual reproduction are potent motivators of behavior. Extrinsic rewards in the environment (i.e. food, drink, money) are also important behavioral and cognitive motivators. In addition to the relevance of an extrinsic reward in meeting the needs of biological drives, an individual’s sensitivity to the physiological state of their body (interoceptive awareness) would also be expected to mediate motivation for these extrinsic primary rewards (i.e. food, drink). Importantly, a better characterization of the predicted behavioral and neural interactions between interoception, motivation, and memory systems can highlight novel targets for interventions to facilitate motivation and memory for adaptive behaviors and/or impede motivation and memory for maladaptive behaviors (i.e.
    [Show full text]
  • Actually Embodied Emotions
    University of Pennsylvania ScholarlyCommons Publicly Accessible Penn Dissertations 2018 Actually Embodied Emotions Jordan Christopher Victor Taylor University of Pennsylvania, [email protected] Follow this and additional works at: https://repository.upenn.edu/edissertations Part of the Philosophy of Science Commons, and the Psychology Commons Recommended Citation Taylor, Jordan Christopher Victor, "Actually Embodied Emotions" (2018). Publicly Accessible Penn Dissertations. 3192. https://repository.upenn.edu/edissertations/3192 This paper is posted at ScholarlyCommons. https://repository.upenn.edu/edissertations/3192 For more information, please contact [email protected]. Actually Embodied Emotions Abstract This dissertation offers a theory of emotion called the primitivist theory. Emotions are defined as bodily caused affective states. It derives key principles from William James’s feeling theory of emotion, which states that emotions are felt experiences of bodily changes triggered by sensory stimuli (James, 1884; James, 1890). However, James’s theory is commonly misinterpreted, leading to its dismissal by contemporary philosophers and psychologists. Chapter 1 therefore analyzes James’s theory and compares it against contemporary treatments. It demonstrates that a rehabilitated Jamesian theory promises to benefit contemporary emotion research. Chapter 2 investigates James’s legacy, as numerous alterations of his theory have influenced the field of emotion research over the past fifty years, including so-called neo-Jamesian theories. This chapter argues that all these variations of the Jamesian theory assume that emotions require mental causes, whether in the form of evaluative judgments or perceptual contents. But this demand is not present in James’s theory. Nor, as Chapter 3 demonstrates, is this assumption necessary or even preferable for a fecund theory that explains human and non-human emotions.
    [Show full text]
  • Lithium Use in Special Populations 10/16/13 9:52 AM
    Lithium use in special populations 10/16/13 9:52 AM Indian J Psychiatry. 2007 Jul-Sep; 49(3): 211–218. PMCID: PMC2902097 doi: 10.4103/0019-5545.37325 Lithium use in special populations E. Mohandas and V. Rajmohan Department of Psychiatry, Elite Mission Hospital, Trichur, Kerala, India Correspondence: Dr. E. Mohandas, E-mail: [email protected] Copyright © Indian Journal of Psychiatry This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Lithium, a monovalent cation, was first used for the treatment of mania in the 1940s. Half a century into its use, the drug continues to be the preeminent choice for bipolar disorder with antimanic, antidepressant (modest) and antisuicidal property. Lithium is the “gold standard” mood stabilizer against which potential mood stabilizer agents are judged. The therapeutic uses of lithium also include use as an augmenting agent in depression, schizoaffective disorder, aggression, impulse control disorder, eating disorders, attention deficit disorder and in certain subsets of alcoholism. Lithium has been used in many medical disorders, especially cluster headache and dermatological disorders (seborrheic dermatitis, eczematoid dermatitis, genital herpes).[1] The drug is however associated with neurologic, endocrine, cardiovascular, renal, dermatologic and gastrointestinal adverse effects and possible teratogenicity. HISTORY Lithium was first discovered and defined by Johan August Arfvedson in 1817 when he did an analysis of the mineral petalite [LiAl(Si2O5)2]. Petalite was first found by Brazilian scientist Josá Bonifécio Andrade e Silva in 1800. Lepidolite, spodumene, petalite and amblygonite are the more important minerals containing lithium.
    [Show full text]
  • Differences Among the General Public and Final Year Counselling and Psychotherapy Students in Emotional Intelligence
    DIFFERENCES AMONG THE GENERAL PUBLIC AND FINAL YEAR COUNSELLING AND PSYCHOTHERAPY STUDENTS IN EMOTIONAL INTELLIGENCE (EI): A QUANTITATIVE STUDY. Ronan Rory Daly Submitted in partial fulfilment of the requirements of the Bachelor of Arts (Honours), Counselling & Psychotherapy, at DBS School of Arts, Dublin. Supervisor: Andre Bolster April 2010 Department of Counselling and Psychotherapy DBS School of Arts Dublin Declaration I hereby certify that this thesis is entirely my own work and has not been submitted as an exercise for a degree at any other university. I agree that the library may lend or copy the thesis on request. Signed ___________________ Ronan R. Daly ii Acknowledgements I would like to express my appreciation to the following individuals: To all the participants who gave generously to the project and without whom this study would not have been possible. To Dr Petrides from the University College of London, for reviewing the study, and for supporting the effort to take these results to publication as an ongoing piece of work. To my academic supervisor, Andre Bolster, who guided, supported and gave me the confidence I needed throughout the entire process. To my classmates, whose valued support and companionship I have experienced in many forms over the past four years. To my parents and family who have always been behind me no matter what endeavours I have put my mind towards, and finally, to Edel, for her time, patience and understanding, not only for this piece of work but throughout this entire so called ‘part time’ process over the last four years. iii Word Count Abstract: 193 Introduction: 7,067 Method: 632 Results: 771 Discussion: 1,531 Total: 10, 194 iv Table of Contents Declaration ...........................................................................................................................
    [Show full text]
  • Investigation to Uncover the Electrophysiological Correlates of the Mediating Cognitive Factors, Responsible for the Immediate Emotional Enhancement of Memory
    Durham E-Theses Investigation to Uncover the Electrophysiological Correlates of the Mediating Cognitive Factors, Responsible for the Immediate Emotional Enhancement of Memory WATTS, SARAH How to cite: WATTS, SARAH (2015) Investigation to Uncover the Electrophysiological Correlates of the Mediating Cognitive Factors, Responsible for the Immediate Emotional Enhancement of Memory, Durham theses, Durham University. Available at Durham E-Theses Online: http://etheses.dur.ac.uk/11069/ Use policy This work is licensed under a Creative Commons Public Domain Dedication 1.0 (CC0) Academic Support Oce, Durham University, University Oce, Old Elvet, Durham DH1 3HP e-mail: [email protected] Tel: +44 0191 334 6107 http://etheses.dur.ac.uk 2 Abstract Emotional memories are powerful memories that have markedly different phenomenological characteristics, compared to neutral memories. Emotional memories are adaptive and serve to aid survival of organisms. Evidence suggests that emotional events tend to be remembered with a greater depth of sensory and perceptual detail. The phenomenon around such memories has therefore been coined, emotion-enhanced memory (EEM). Much of the research into EEM has focused on the long-term consolidating affects that emotions can have upon memory; with the modulation hypothesis being the predominant theory in the literature. However, it has been noted in the literature that emotional stimuli can also enhance short-term memories, immediately after test. It is suggested that the immediate EEM is driven by changes in the cognitive attributes of emotional stimuli, which facilitates encoding processes; this is known as the cognitive-mediating account of immediate EEM. This research aims to investigate three of the key cognitive mediating factors, implicated in the behavioural literature; distinctiveness, relatedness and attention.
    [Show full text]
  • Archives of Neurology & Neurological Disorders
    Archives of Neurology & Neurological Disorders Commentary | Vol 2 Iss 1 Not So Easy to Define Emotional Brain Carlito Navarro1, Romanescu Popei1 and Muller G. Hito2* 1Msc, Vasile Alecsandri de Bacău University, Romania 2PhD, Department of Psychology and Sports Science Justus-Liebig University, Germany *Corresponding author: Hito MG, PhD, Department of Psychology and Sports Science Justus-Liebig University, Germany, Tel: +49 (0) 641/99-25230; E-mail: [email protected] Received: April 01, 2019; Accepted: April 12, 2019; Published: April 18, 2019 Emotion is a vague concept and is difficult to define like Alvarado et al. explained in their research in 2002. It has the particularity of being idiosyncratic, that is, particular and specific to each individual like showed by Picard et Al. the next year. As a result, several definitions and roles have been given to emotion. As early as 1879, Charles Darwin, founder of the theory of evolution, defined it as the ability of the living organism to adapt and survive. He sees her as innate, universal and communicative. From a behavioural point of view, emotion is perceived as a "motivator", an entity that influences an individual's choice in response to an external or internal stimulus [1-4]. From a socio-cultural point of view, feelings are the response given to an interaction with ourselves and/or with others [5-9]. An emotion exists in both the personal and social dimension of the individual. It would be this capacity for adaptation and change, this link that shapes our relationships and puts us in interaction with the other [10].
    [Show full text]
  • Thomas A. Ban: Neuropsychopharmacology in Historical Perspective
    1 Thomas A. Ban: Neuropsychopharmacology in Historical Perspective Collated 36 Thomas A. Ban Lithium 5. Turning point Paul Grof and Johan Schioldann Contents Paul Grof: More hindsight thoughts Barry Blackwell’s review of Johan Schioldann: History of the Introduction of Lithium into Medicine and Psychiatry: Birth of Modern Psychopharmacology 1949 - Johan Schioldann’s comments on Barry Blackwell’s review Paul Grof: More hindsight thoughts Barry Blackwell’s two sets of comments (2019a,b) on Mogens Schou: My journey with lithium revisit events that happened five decades ago. It’s helpful to look at the happenings, in hindsight, to see what we can still learn. 2 While incorrect, Blackwell and Shepherd’s 1968 critique of lithium studies (Blackwell and Shepherd 1968) was beneficial and served a crucial function. I had stated that repeatedly. At that time, Mogens Schou, Jules Angst and I wavered to proceed to a placebo test of our findings. Without Blackwell and Shepherd’s article, a strict placebo test and the subsequent introduction of lithium into stabilizing bipolar treatment may have been delayed for a long time. Many bipolar patients would have missed stability. As Leonardo Tondo correctly stresses (Tondo 2019) our intense hesitation to conduct a double-blind discontinuation trial was based on concerns about patient well-being. Patients included in our open studies were not like patients who nowadays start taking lithium after a brief illness. The several hundred patients included in the open evaluation (Baastrup and Schou 1967; Angst, Grof and Schou 1970) had often been sick for countless years before starting lithium; many had also attempted suicide.
    [Show full text]