Digital @ Dentsu Aegis Network
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Genome Editing with CRISPR/Cas9 in Postnatal Mice Corrects PRKAG2 Cardiac Syndrome
Cell Research (2016) 26:1099-1111. © 2016 IBCB, SIBS, CAS All rights reserved 1001-0602/16 $ 32.00 ORIGINAL ARTICLE www.nature.com/cr Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome Chang Xie1, 2, *, Ya-Ping Zhang3, *, Lu Song2, *, Jie Luo1, Wei Qi2, Jialu Hu3, Danbo Lu3, Zhen Yang3, Jian Zhang2, Jian Xiao1, Bin Zhou4, Jiu-Lin Du5, Naihe Jing2, Yong Liu1, Yan Wang1, Bo-Liang Li2, Bao-Liang Song1, Yan Yan3 1Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China; 2The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; 3Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China; 4Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sci- ences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; 5Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Acade- my of Sciences, 320 Yue-Yang Road, Shanghai 200031, China PRKAG2 cardiac syndrome is an autosomal dominant inherited disease resulted from mutations in the PRK- AG2 gene that encodes γ2 regulatory subunit of AMP-activated protein kinase. Affected patients usually develop ventricular tachyarrhythmia and experience progressive heart failure that is refractory to medical treatment and requires cardiac transplantation. In this study, we identify a H530R mutation in PRKAG2 from patients with famil- ial Wolff-Parkinson-White syndrome. By generating H530R PRKAG2 transgenic and knock-in mice, we show that both models recapitulate human symptoms including cardiac hypertrophy and glycogen storage, confirming that the H530R mutation is causally related to PRKAG2 cardiac syndrome. -
Ascential Secure
Ascential Secure Enhanced Health & Safety Standards at Ascential’s Events in a Post-COVID-19 World 1 About Ascential Secure Ascential Secure is our approach to enhanced health and safety standards at our events following COVID-19. From exhibitors to sponsors, speakers, visitors and journalists, those who come to our events do so to gain the information, insights, connections, data and digital tools that they need, effectively and safely. The standards and practices that make up Ascential Secure are designed to provide confidence that at every Ascential event, we are striving to provide the highest standards of safety, hygiene, cleanliness and quality. Whether they are exhibitors, attendees, visitors, speakers or sponsors, people come to events to connect, learn, know more and do more business, effectively, safely and with confidence. Ascential Secure is based on a set of event industry standards, called AllSecure. The AllSecure industry standards were developed collaboratively by a group including industry associations UFI, AEO and SISO, event organisers Informa, Reed Exhibitions and Clarion, a range of event venues, suppliers and with input from health, government and local authorities. Ascential Secure is the way these industry-wide AllSecure standards are being applied to Ascential live events. You can expect to see that health and safety continues to be a priority, and that a range of measures are in place to ensure everyone involved is able to enjoy a safe, hygienic, productive and high-quality organised event experience. As a starting point, Ascential Secure events will be run according to the guidance of the government or official local authority for that location, and according to any venue-specific regulations. -
Annual Report 2020
In pursuit of progress since Annual report 2020 report Annual Annual report 2020 In pursuit of progress since Annual report 2020 report Annual Annual report 2020 CONTENTS ANNUAL REPORT STRATEGIC REPORT 2 Five-year summary 3 Group overview 4 From the chairman 6 From the chief executive 8 From the editor 9 Business review: the year in detail 13 The Economist Educational Foundation 15 The Economist Group and environmental sustainability 17 Corporate governance: the Wates Principles, our Section 172(1) statement and our guiding principles REPORT AND ACCOUNTS GOVERNANCE 22 Directors 23 Executive team 24 Trustees, board committees 25 Directors’ report 28 Directors’ report on remuneration 31 Financial review CONSOLIDATED FINANCIAL STATEMENTS 35 Independent auditor’s report to the members of The Economist Newspaper Limited 38 Consolidated income statement 39 Consolidated statement of comprehensive income 40 Consolidated balance sheet 41 Consolidated statement of changes in equity 42 Consolidated cashflow statement 44 Notes to the consolidated financial statements COMPANY FINANCIAL STATEMENTS 94 Company balance sheet 95 Company statement of changes in equity 96 Notes to the company financial statements NOTICES 108 Notice of annual general meeting 1 STRATEGIC REPORT Five-year summary 2020 2019 2018 2017 2016 £m £m £m £m £m Income statement—continuing business* Revenue 326 333 329 303 282 Operating profit 31 31 38 43 47 Profit after taxation 21 25 28 39 37 Profit on sale of CQ-Roll Call, Inc - 43 - - - Profit on sale of Economist Complex - - - - -
Annual Report 2012
BRINGING How we have performed KNOWLEDGE FIN ANCIAL HIGHLIGHTS • Record adjusted diluted EPS up 7.7% to 40.7p (2011: 37.8p), ahead of market expectations TO LIFE • Full year dividend increased by 10.1% – second interim dividend of 12.5p giving a total 2012 dividend of 18.5p (2011: 16.8p) Businesses, professionals and • Revenue broadly flat despite Robbins Gioia and European academics worldwide turn to Informa Conference disposals – £1.23bn (2011: £1.28bn) for unparalleled knowledge, up-to- • Adjusted operating profit up 4.0% to £349.7m the minute information and highly (2011: £336.2m); organic growth of 2.8% specialist skills and services. • Record adjusted operating margin of 28.4% (2011: 26.4%) Our ability to deliver high quality • Adjusted profit before tax of £317.4m up 7.3% (2011: £295.9m) knowledge and services through • Statutory profit after tax of £90.7m (2011: £74.3m) multiple channels, in dynamic and rapidly changing environments, • Strong cash generation – operating cash flow up 5.7% to £329.0m (2011: £311.2m) makes our offer unique and • Balance sheet strength maintained – net debt/EBITDA extremely valuable to individuals ratio of 2.1 times (2011: 2.1 times) and organisations. OPEAI R T ONAL HIGHLIGHTS • Proactive portfolio management drives significant Annual Report & Financial Statements for the year ended December 31 2012 improvement in the quality of Group earnings • Total product rationalisation reduced Group revenue by 2% • Investment in new products, geo-cloning and platform development • Acquisition of MMPI and Zephyr -
Strategic Orientation Document for Malaria Vector Surveillance and Control in Latin America and the Caribbean
Amazon Malaria Initiative/ Amazon Network for the Surveillance of Antimalarial Drug Resistance Strategic Orientation Document for Malaria Vector Surveillance and Control in Latin America and the Caribbean INICIATIVA AMAZÓNICA CONTRA LA MALARIA/ RED AMAZÓNICA DE VIGILANCIA DE LA RESISTENCIA A LOS ANTIMALÁRICOS Documento estratégico para la gestión del suministro y garantía de la calidad de los medicamentos e insumos para el diagnóstico y tratamiento de la malaria Recommended Citation: US Centers for Disease Control and Prevention (CDC), Pan American Health Organization (PAHO/WHO), and RTI. 2011. Strategic Orientation Document for Malaria Vector Surveillance and Control in La tin America and the Caribbean. Submitted to the U.S. Agency for International Development by the CDC and Links Media, LLC. Gaithersburg, MD. Available at http://www.usaidami.org/resources.shtml Amazon Malaria Initiative/ Amazon Network for the Surveillance of Antimalarial Drug Resistance TABLE OF CONTENTS 1. Glossary / 5 2. Acronyms and abbreviations / 6 3. Objective / 7 4. Introduction / 9 5. Vector control / 11 5.1 Indoor residual spraying / 12 5.2 Insecticide-treated nets / 13 5.3 Source reduction / 14 5.4 Integrated vector management / 15 6. Vector surveillance / 17 6.1 Entomological surveillance / 18 6.2 Monitoring vector control operations / 22 6.3 Entomological indicators / 23 6.4 Operational indicators / 25 7. Monitoring plans per epidemiological strata / 29 7.1 Moderate to low-transmission settings / 29 7.2 Low to very low-transmission settings / 31 7.3 Settings with no active transmission but risk of transmission / 33 8. References / 35 9. Annexes / 39 Annex 1: Malaria vectors in the Americas / 39 Annex 2: WHO recommended insecticides for indoor residual spraying / 40 Annex 3: WHO recommended long-lasting insecticide-treated nets / 41 Strategic Orientation Document for Malaria Vector Surveillance and Control in Latin America and the Caribbean 3 About this document: This document was produced through the Amazon Malaria Initiative (AMI) and was financed by the U.S. -
Accès Aux Médias Audiovisuels Plateformes & Enjeux
L’accès aux médias audiovisuels Plateformes & enjeux Sommaire 01 PAYSAGE p.7 02 RÉGLEMENTATION p.25 03 CONSOMMATION p.37 04 ENJEUX ÉCONOMIQUES p.51 05 PROTECTION DU CONSOMMATEUR ET DU PUBLIC p.65 06 L’ACCÈS À L’OFFRE p.73 07 ÉVOLUTION DU CADRE RÉGULATOIRE p.89 éditorial Au sens du décret sur les services de médias audiovisuels (SMA), un distributeur de services est une personne qui met à disposition du public un ou des services de médias audiovisuels. Ces services sont généralement édités par d’autres personnes que le distribu- teur, mais ces deux fonctions se confondent de plus en plus, bous- culant la chaîne de valeur traditionnelle. Le distributeur de services joue un rôle fondamental dans l’accès du public à l’offre de SMA. Le distributeur est aussi un vecteur in- contournable pour un nombre croissant d’éditeurs. En pratique, la Dominique Vosters distribution de SMA constitue autant un enjeu démocratique et Président du Conseil supérieur culturel qu’un enjeu économique. Ceci justifie pleinement la régu- de l’audiovisuel lation de ce secteur dans un cadre fixé par les législateurs belges et européen. Après avoir dressé un panorama des différents types de distri- bution disponibles en Fédération Wallonie-Bruxelles, le présent Il y a bien longtemps que le public francophone belge s’est habi- ouvrage examinera les divers modes de consommation des SMA tué à recourir à un intermédiaire pour accéder à un SMA. Sans re- qui y sont identifiés, particulièrement ceux qui recourent à de nou- monter à la radio par câble développée à Bruxelles, c’est dans les veaux moyens de distribution. -
Pioneering Tool to Manage Media Industry's Digital Carbon Footprint 13 January 2020
Pioneering tool to manage media industry's digital carbon footprint 13 January 2020 industry understand and manage the carbon impact of digital media. Mapping the carbon footprint of digital services like advertising, publishing and broadcasting is difficult because the underlying technological systems are hugely complex and constantly shifting. Media content passes through content delivery networks, data centres, web infrastructure and user devices, to name just a few, with each element of the delivery chain having different owners. With climate change high on the agenda, DIMPACT The online tool with help media industry manage its will allow participating companies to understand digital carbon footprint. Credit: Pixabay/ University of their 'downstream' carbon impacts, right through to Bristol the end-user. This, in turn, will enable more informed decision-making to reduce the overall carbon footprint of digital services. A collaboration between computer scientists at the University of Bristol and nine major media "We know that more and more of our interactions companies, including ITV and BBC, will help the happen online, and screens play an ever more media industry understand and manage the important role in our lives. We can say with significant carbon impacts of digital content. absolute certainty that the digital economy will continue to grow. What we don't know is how those The 12-month collaboration, facilitated by modes of digital consumption translate into carbon sustainability experts, Carnstone, will see impacts and where the 'hotspots' reside. DIMPACT University of Bristol researchers working with will change that," said Christian Toennesen, Senior sustainability and technology teams at the BBC, Partner at Carnstone and DIMPACT's initiator and Dentsu Aegis Network, Informa, ITV, Pearson, product manager. -
Monthly Business & Tech-Enabled Services Sector Summary Report
BUSINESS AND TECH-ENABLED SERVICES SECTOR REPORT March 2018 1 BUSINESS & TECH-ENABLED SERVICES DEAL DASHBOARD $94.4 Billion 788 M&A Volume YTD M&A Transactions YTD Quarterly M&A Volume ($Bn) and Deal Count Select M&A Transactions 100 $94.4 Announced Date Acquirer Target EV ($MM) 80 3/29/2018 NA 60 $48.5 $45.1 $45.5 $37.1 3/29/2018 NA 40 $31.1 $24.6 $27.4 $26.9 $19.1 $19.2 $21.7 Volume ($Bn) Volume $14.9 20 3/28/2018 $4,000 (Sig. M inority Stake) 0 3/26/2018 NA Q1 '15Q2 '15Q3 '15Q4 '15Q1 '16Q2 '16Q3 '16Q4 '16Q1 '17Q2 '17Q3 '17Q4 '17Q1 '18 (Investment) 1200 3/21/2018 NA 966 944 964 995 986 1000 901 929 917 875 894 797 788 788 800 3/21/2018 NA 600 3/19/2018 $1,180 Deal Count Deal 400 200 3/15/2018 $383 0 Q1 '15Q2 '15Q3 '15Q4 '15Q1 '16Q2 '16Q3 '16Q4 '16Q1 '17Q2 '17Q3 '17Q4 '17Q1 '18 3/15/2018 NA (1) Last 12 Months Business & Tech-Enabled Services Performance vs. S&P 500 3/14/2018 NA (Investment) 125.0% 3/13/2018 $205 120.0% 115.0% 3/13/2018 NA 110.0% 105.0% 3/12/2018 $108 100.0% 3/6/2018 $564 95.0% 90.0% 3/5/2018 NA Apr-17 May-17 Jun-17 Jul-17 Aug-17 Sep-17 Oct-17 Nov-17 Dec-17 Jan-18 Feb-18 Mar-18 Apr-18 Business & Tech-Enabled Services S&P 500 3/1/2018 NA (Investment) Notes: 2 Source: Capital IQ and PitchBook. -
CARAT Client: MANAPPURAM a Trading Division Under Dentsu Manappuram Finance Ltd Aegis Network Communications Lndia Private Limited
6*ep COTIFIDENTIAL DENTSU AEGIS NETWORK SERVICES AGREEMENT COMMERCIAL TERM SHEE]' .: . l:r : :r '::: :PARi[IES:, Agepc CARAT Client: MANAPPURAM A trading division under Dentsu Manappuram Finance Ltd Aegis Network Communications lndia Private Limited Cl N : U74300MH1986PTC039002 Address: 601-8 Wing, Poonam Chambers, Addr.€.' w l 47O (old) W63BA (New), l:, l:- l1 . ,:1:: l'1. Manappuram House, Valapad, DR. A B Road, Worli, Mumbai- :,:.1:; :.1 r:::::i.: l; !;ii, r. '- 400018 ir:. r::r:-:. l Thrissur, l(erala,lndia - 680 567 TERIV'Ii' rl GI Start,Date: .TUN€ >o\'t O I Tu uY wlV 30 ;l X AUTO RENEW EI --l-lrrlf-r- : - -:: _::-: CI SERV-leEil ,:,.;i; - -,. ;:N -"i Qr- AII lndia except Kerala iht d t- *i tr lVledia Services ril ;i D Creative Services ;; it ]> "-t Z E other Services 1.) )j U p F The Services are more particularly described in each applicable Statement of Wofk.s* BilbS U Mediir I Offline # nEffitr i i,lr, i : r::. r tr'Out of Home H $HHtr i"il s s#fi* li ili El Digital Services {including Display, Performance, SEM, Social, Mobile) ff oSi*x 'l itii H !s!)ttr , $t*="' tf ("T&Cs") nd schedrrles ttw,rijq$-.i This Commercial Term Sheet must be read alongside the Terms and Conditions and schedullgs H are attached to this CommercialTerm Sheet. The T&Cs and schedules, together with this Commercial TEm S h'dct fr paYties; aand' entered into on 08 day of April 2019 constitute a binding agreement f'Agreement") between the 0l will apply to any media schedule, work order and/or any services supplied to the Client by Agency duringI trne Executed for and on behalf of CIi nt//":;. -
Media Key Facts
media key facts 2015 Rue du Moulin à Papier - 55 - Papiermolenstraat | Bruxelles - 1160 - Brussel Tel +32 (0)2 663 51 11 | [email protected] content Dentsu Aegis Network Belgium _______________________ 5 Economy & Demography ____________________________ 9 Media Spend _____________________________________ 19 Plurimedia Facts __________________________________ 25 Television _______________________________________ 37 Radio __________________________________________ 51 Cinema _________________________________________ 59 Newspapers _____________________________________ 65 Magazines _______________________________________ 73 Free Regional Press _______________________________ 83 Out of Home ____________________________________ 89 Internet _______________________________________ 103 Social Media ___________________________________ 115 On Line Search _________________________________ 123 iDTV __________________________________________ 137 Live Communication ______________________________ 141 Grand Duchy of Luxembourg _______________________ 145 Media Jargon ___________________________________ 157 Media Studies __________________________________ 173 Useful Addresses ________________________________ 183 dentsu aegis network belgium dentsu aegis network belgium Carat & Vizeum are the media agencies belonging to Dentsu Aegis Network Belgium. Responsible Publisher : Anne Bataille (CEO, Dentsu Aegis Network Belgium) Editorial Team : Alessandro Asproni (Out of Home - Cinema), Claire Berge (Lay-out), Dany Dernoncourt (Media Spend), Philippe -
CIM RADIO STREAM MONITOR a New Server-Side Online Radio Measurement INTRODUCTION
CIM RADIO STREAM MONITOR A new server-side online radio measurement INTRODUCTION In addition to the Currency Radio Audience Measurement (RAM) study, the CIM offers a new tool dedicated to online radio: the Radio Stream Monitor, which monitors the broadcasting of radios on all streaming platforms, both in Belgium and in the rest of the world on the basis of traffic volumes (and not of users and their profiles). A NEW BORN IN THE CIM AUDIO MEASUREMENT FRAMEWORK CIM RAM CIM Internet NEW CIM Radio Stream = All Audio GfK Gemius Monitor CURRENCY Neuromedia Live Radio FM/DAB ✓ Included - - Over IP (internet protocol) ✓ Included ✓ Included* ✓ Included Audio on demand Podcast/Time shifted - ✓ Included* - Other Audio over IP - - - Method Radio diaries User-side log analysis Server-side log analysis Sample based Traffic on census level Traffic on census level Profile panel based Limit Declared Behavior *Only scripted players Distribution of audio files (not listening) SERVER-SIDE MEASUREMENT PRINCIPLES 1. This study identifies traffic volumes, based on combinations of IP address and user agent, NOT individuals. 2. The data sources are logfiles from streaming servers that list the number of audio streams distributed (but not necessarily listened to). 3. This measurement of Radio-over-IP is exhaustive, as it involves: - All channels (from broadcasters that allow access to their server logfiles) - All events (streams requested and distributed over IP) - On all listening platforms (see next slide…) The study is done by NeuroMedia, a Belgian specialist -
Gestandaardiseerde Fiche
Gestandaardiseerde fiche Operator Proximus Tariefplan Epic combo light TV experience Datum laatste update 01/08/2020 Uiterste geldigheidsdatum Vaste Mobiele Vast Mobiel Dienstencomponenten Digitale TV telefonie diensten internet internet Kosten Maandabonnement (€/maand) €64,99 Activering (€) 0 Installatie € Door de operator Ja Nee 0 OF Door de klant Ja Nee 0 Aansluiting Telefoonlijn TV-kabel Huur van de lijn (€/maand) Modem € Ja Nee Aankoop (€) OF Huur (€/maand) Inbegrepen Satellietparabool Ja Nee Aankoop (€) OF Huur (€/maand) Contractuele voorwaarden Verbrekingsvergoeding binnen eerste 6 Onbepaalde duur Duur (maanden) Ja Nee maanden Afschrijvingstabel voor koppelverkoop Ja Nee Type toestel Terugkerende tariefelementen aangeboden met korting Duur Voordelen • Proximus raadt aan een modem te gebruiken die in haar catalogus vermeld wordt. Indien de klant opteert voor een andere modem is Proximus niet aansprakelijk voor het gebruik en/of het onderhoud ervan. • 100 Mbps is de maximale surfsnelheid aangeboden aan onze klanten. De aangekondigde maximale snelheid is een theoretische snelheid, voor de vaste internetverbinding die in de praktijk niet door alle klanten behaald kan worden. Je downloadsnelheid thuis hangt voornamelijk af van de afstand tussen het aansluitingspunt en de centrale, de beschikbaarheid van VDSL, je computerinstallatie en de binnenbekabeling. Enkel als deze optimaal zijn, kan je genieten van de maximale snelheid. Gebruik van een draadloze connectie (wifi) kan de haalbare snelheid eveneens beïnvloeden. Meer info : www.proximus.be/internetpolicy. Is fiber beschikbaar voor jou ? Je kan dan kiezen voor Epic combo Fiber light TV experience en genieten van snelheden tot 120 Mbps om te downloaden en tot 20 Mbps om te uploaden, evenals alle andere voordelen van fiber.