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Endothelium-Independent Vasorelaxation by Dichloromethanolic Fraction from Anogeissus Leiocarpa (DC) Guill. Et Perr. (Combretace
Vol. 13(4), pp. 25-35, 22 February, 2019 DOI: 10.5897/AJPP2018.4992 Article Number: 5AC3DCE60214 ISSN: 1996-0816 Copyright ©2019 African Journal of Pharmacy and Author(s) retain the copyright of this article Pharmacology http://www.academicjournals.org/AJPP Full Length Research Paper Endothelium-independent vasorelaxation by dichloromethanolic fraction from Anogeissus leiocarpa (DC) Guill. Et Perr. (Combretaceae) bark of trunk on 2+ porcine coronary artery rings: Involvement of [Ca ]i decreased and phosphodiesterases inhibition Belemnaba Lazare1,2*, Nitiéma Mathieu2,3, Ouédraogo Sylvin2, Auger Cyril1, Schini-Kerth Valérie B. 1 and Bernard Bucher1 1UMR CNRS 7213, Laboratoire de Biophotonique et Pharmacologie, Faculté de Pharmacie Université de Strasbourg, Illkirch, France 2Institut de Recherche en Sciences de la Santé (IRSS/CNRST), Ouagadougou, Burkina Faso 3 Université Ouaga I Pr Joseph KI-ZERBO, Ouagadougou, Burkina Faso Received 20 December, 2018; Accepted 16 January, 2019 Anogeissus leiocarpa (DC) Guill. et Perr. belongs to the Combretaceae family and was previously named A. leiocarpa (DC) Guill. Et Perr. It has been widely used in Burkina Faso by traditional medicine for the treatment of hypertension. Previous study showed that the dichloromethanolic fraction from the barks of trunk of A. leiocarpa (ALF) has induced an endothelium-independent and endothelium- dependent vasodilation effect and had the capacity to inhibit in vitro, purified cyclic nucleotide phosphodiesterases (PDEs) activity. The aims of this study were to better underline ALF-induced endothelium-independent vasorelaxation in an organ model. The results showed that ALF significantly reduce the contractile response to U46619 in porcine coronary artery rings without endothelium that were in concentration-dependent manner. -
Australian Tropical Rainforest Plants - Online Edition
Australian Tropical Rainforest Plants - Online edition Family Profile Combretaceae Family Description A family of about 20 genera and nearly 500 species, pantropic, well developed in Africa; five genera occur naturally in Australia. Genera Combretum - A genus of about 250 species, pantropic; one species occurs naturally in Australia. Exell (1954); Pedley (1990). Dansiea - A genus of two species endemic to Australia. Byrnes (1981); Pedley (1990). Macropteranthes - A genus of five species endemic to Australia. Cooper & Cooper (2004); Forster (1994); Harden et al. (2014); Pedley (1990); Stace (2007). Quisqualis - A genus of about 17 species in Africa, Asia and Malesia. Exell (1954). One species may have become naturalised in Australia. Terminalia - A genus of about 200 species, pantropic; 24 species occur naturally in Australia. Byrnes (1977); Coode (1973, 1978); Pedley (1990), Stace (2007). References Byrnes, N.B. (1977). A revision of Combretaceae in Australia. Contributions from the Queensland Herbarium No. 20:1-88. Byrnes, N.B. (1981). Addition to Combretaceae (Lagunclurieae) from Australia. Austrobaileya 1:385-387. Coode, M.J.E. (1973). Notes on Terminalia L. (Combretaceae) in Papuasia. Contributions from Herbarium Australiense 2:1-33. Coode, M.J.E. (1978). Combretaceae. In Womersley, J.S. (Ed.) 'Handbooks of the flora of Papua New Guinea.' Vol. 1, (Melbourne University Press: Melbourne.), pp. 43-110. Cooper, Wendy & Cooper, William T. (2004) Fruits of the Australian tropical rainforest, Nokomis Publications, Clifton Hill, Vic. Exell, A.W.C. (1954). Combretaceae. In 'Flora Malesiana.' Ser. 1, Vol. 4, (P. Noordhoff Ltd: Groningen.), pp. 533-589. Forster, P.I. (1994). Notes on Dansiea Byrnes and Macropteranthes F. -
The Effects of Linear Developments on Wildlife
Bibliography Rec# 5. LeBlanc, R. 1991. The aversive conditioning of a roadside habituated grizzly bear within Banff Park: progress report 1991. 6 pp. road impacts/ grizzly bear/ Ursus arctos/ Banff National Park/ aversive conditions/ Icefields Parkway. Rec# 10. Forman, R.T.T. 1983. Corridors in a landscape: their ecological structure and function. Ekologia 2 (4):375-87. corridors/ landscape/ width. Rec# 11. McLellan, B.N. 1989. Dymanics of a grizzly bear population during a period of industrial resource extraction. III Natality and rate of increase. Can. J. Zool. Vol. 67 :1865-1868. reproductive rate/ grizzly bear/ Ursus arctos/ British Columbia/ gas exploration/ timber harvest. Rec# 14. McLellan, B.N. 1989. Dynamics of a grizzly bear population during a period of industrial resource extraction. II.Mortality rates and causes of death. Can. J. Zool. Vol. 67 :1861-1864. British Columbia/ grizzly bear/ Ursus arctos/ mortality rate/ hunting/ outdoor recreation/ gas exploration/ timber harvest. Rec# 15. Miller, S.D., Schoen, J. 1993. The Brown Bear in Alaska . brown bear/ grizzly bear/ Ursus arctos middendorfi/ Ursus arctos horribilis/ population density/ distribution/ legal status/ human-bear interactions/ management/ education. Rec# 16. Archibald, W.R., Ellis, R., Hamilton, A.N. 1987. Responses of grizzly bears to logging truck traffic in the Kimsquit River valley, British Columbia. Int. Conf. Bear Res. and Manage. 7:251-7. grizzly bear/ Ursus / arctos/ roads/ traffic/ logging/ displacement/ disturbance/ carnivore/ BC/ individual disruption / habitat displacement / habitat disruption / social / filter-barrier. Rec# 20. Kasworm, W.F., Manley, T.L. 1990. Road and trail influences on grizzly bears and black bears in northwest Montana. -
Anogeissus Acuminata (Roxb) Wall Ex Bedd in Vitro
International Journal of Complementary & Alternative Medicine Review Article Open Access Detection of free radical scavenging activity of dhaura, anogeissus acuminata (roxb) wall ex bedd in vitro Abstract Volume 12 Issue 4 - 2019 The free radical inhibitory activity of Dhaura, Anogeissus acuminata extracted in chloroform, ethanol and water was investigated in vitro. The DPPH inhibition by the Ganesh Chandra Jagetia, Zairempuii different stem extract depended on the concentration and the ethanol extract was found Department of Zoology, Mizoram University, India to be the most potent as the lower concentration of it was most effective in scavenging Correspondence: Ganesh Chandra Jagetia, Department of different free radicals. The analysis of superoxide radical scavenging activity showed that Zoology, Mizoram University, India, Email the aqueous extract was most effective when compared to chloroform and ethanol extracts. The different extracts of Dhaura also inhibited the generation of nitric oxide radical Received: August 5, 2019 | Published: August 27, 2019 depending on its concentration and maximum effect was observed at 200μg/ml. Our study indicates that free radical scavenging activity of Dhaura affirms the medicinal use by the practitioners of folklore medicine. Keywords: anogeissus acuminata, DPPH, superoxide, nitric oxide, endoplasmic reticulum, peroxisomes, mitochondria Abbreviations: EDTA, ethylenediaminetetraacetic acid; enlargement of spleen cold, dysuria, cough, excessive perspiration, 15 NBT, nitrobluetetrazolium; TCA, trichloroacetic acid; NED, N–(1– cholera, urinary disorders, snake bite and in scorpion sting. The Naphthyl)ethylenediamine dihydrochloride gum produced by Dhaura is called Ghatti or Indian gum and is used as a tonic after delivery.15,16 The preclinical studies have shown the Introduction alleviation of alloxan–induced diabetes in rats.17. -
Chemistry and Pharmacology of Kinkéliba (Combretum
CHEMISTRY AND PHARMACOLOGY OF KINKÉLIBA (COMBRETUM MICRANTHUM), A WEST AFRICAN MEDICINAL PLANT By CARA RENAE WELCH A Dissertation submitted to the Graduate School-New Brunswick Rutgers, The State University of New Jersey in partial fulfillment of the requirements for the degree of Doctor of Philosophy Graduate Program in Medicinal Chemistry written under the direction of Dr. James E. Simon and approved by ______________________________ ______________________________ ______________________________ ______________________________ New Brunswick, New Jersey January, 2010 ABSTRACT OF THE DISSERTATION Chemistry and Pharmacology of Kinkéliba (Combretum micranthum), a West African Medicinal Plant by CARA RENAE WELCH Dissertation Director: James E. Simon Kinkéliba (Combretum micranthum, Fam. Combretaceae) is an undomesticated shrub species of western Africa and is one of the most popular traditional bush teas of Senegal. The herbal beverage is traditionally used for weight loss, digestion, as a diuretic and mild antibiotic, and to relieve pain. The fresh leaves are used to treat malarial fever. Leaf extracts, the most biologically active plant tissue relative to stem, bark and roots, were screened for antioxidant capacity, measuring the removal of a radical by UV/VIS spectrophotometry, anti-inflammatory activity, measuring inducible nitric oxide synthase (iNOS) in RAW 264.7 macrophage cells, and glucose-lowering activity, measuring phosphoenolpyruvate carboxykinase (PEPCK) mRNA expression in an H4IIE rat hepatoma cell line. Radical oxygen scavenging activity, or antioxidant capacity, was utilized for initially directing the fractionation; highlighted subfractions and isolated compounds were subsequently tested for anti-inflammatory and glucose-lowering activities. The ethyl acetate and n-butanol fractions of the crude leaf extract were fractionated leading to the isolation and identification of a number of polyphenolic ii compounds. -
Phytochemical Constituents of Combretum Loefl. (Combretaceae)
Send Orders for Reprints to [email protected] 38 Pharmaceutical Crops, 2013, 4, 38-59 Open Access Phytochemical Constituents of Combretum Loefl. (Combretaceae) Amadou Dawe1,*, Saotoing Pierre2, David Emery Tsala2 and Solomon Habtemariam3 1Department of Chemistry, Higher Teachers’ Training College, University of Maroua, P.O.Box 55 Maroua, Cameroon, 2Department of Earth and Life Sciences, Higher Teachers’ Training College, University of Maroua, P.O.Box 55 Ma- roua, Cameroon, 3Pharmacognosy Research Laboratories, Medway School of Science, University of Greenwich, Cen- tral Avenue, Chatham-Maritime, Kent ME4 4TB, UK Abstract: Combretum is the largest and most widespread genus of Combretaceae. The genus comprises approximately 250 species distributed throughout the tropical regions mainly in Africa and Asia. With increasing chemical and pharma- cological investigations, Combretum has shown its potential as a source of various secondary metabolites. Combretum ex- tracts or isolates have shown in vitro bioactivitities such as antibacterial, antifungal, antihyperglycemic, cytotoxicity against various human tumor cell lines, anti-inflammatory, anti-snake, antimalarial and antioxidant effects. In vivo studies through various animal models have also shown promising results. However, chemical constituents and bioactivities of most species of this highly diversified genus have not been investigated. The molecular mechanism of bioactivities of Combretum isolates remains elusive. This review focuses on the chemistry of 261 compounds isolated and identified from 31 species of Combretum. The phytochemicals of interest are non-essential oil compounds belonging to the various struc- tural groups such as terpenoids, flavonoids, phenanthrenes and stilbenoids. Keywords: Combretum, phytochemistry, pharmacology, terpenoids, polyphenolic compounds, antibacterial activity, antifungal activity. INTRODUCTION is sometimes persistant, and especially in climbers it forms a hooked wooded spine when the leaf abscises. -
Variation in Antibacterial Activity of Schotia Species
South African Journal of Botany 2002, 68: 41–46 Copyright © NISC Pty Ltd Printed in South Africa — All rights reserved SOUTH AFRICAN JOURNAL OF BOTANY ISSN 0254–6299 Variation in antibacterial activity of Schotia species LJ McGaw, AK Jäger and J van Staden* Research Centre for Plant Growth and Development, School of Botany and Zoology, University of Natal Pietermaritzburg, Private Bag X01, Scottsville 3209, South Africa * Corresponding author, e-mail: [email protected] Received 29 March 2001, accepted in revised form 7 June 2001 The roots and bark of Schotia brachypetala are used in ture, or as an extract residue at -15°C, had little effect on South African traditional medicine as a remedy for the antibacterial activity. In general, the ethanolic dysentery and diarrhoea. The paucity of pharmacologi- extracts were more active than the aqueous extracts. cal and chemical data on this plant prompted an inves- The chemical profiles on TLC chromatograms were tigation into its antibacterial activity. The differences in compared and found to be very similar in the case of activity of ethanol and water extracts with respect to ethanol extracts prepared in different months of the plant part, season and geographical position were year, and from different trees. The extracts of the three analysed. No extreme fluctuations in activity were species and of the leaves stored under various condi- noted. Two other Schotia species, S. afra and S. capita- tions also showed similar TLC fingerprints, however, ta, were included in the study, and both displayed good various plant parts of S. brachypetala showed distinctly in vitro antibacterial activity. -
Pharmacoinformatics and UPLC-QTOF/ESI-MS-Based Phytochemical Screening of Combretum Indicum Against Oxidative Stress and Alloxan-Induced Diabetes in Long–Evans Rats
molecules Article Pharmacoinformatics and UPLC-QTOF/ESI-MS-Based Phytochemical Screening of Combretum indicum against Oxidative Stress and Alloxan-Induced Diabetes in Long–Evans Rats Md. Shaekh Forid 1, Md. Atiar Rahman 2,* , Mohd Fadhlizil Fasihi Mohd Aluwi 3, Md. Nazim Uddin 4 , Tapashi Ghosh Roy 5 , Milon Chandra Mohanta 6 , AKM Moyeenul Huq 7,* and Zainul Amiruddin Zakaria 8,* 1 Department of Pharmacy, School of Science and Engineering, Southeast University, Dhaka 1213, Bangladesh; [email protected] 2 Department of Biochemistry & Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh 3 Faculty of Industrial Science and Technology, Universiti Malaysia Pahang, Kuantan 26300, Pahang, Malaysia; [email protected] 4 Institute of Food Science and Technology, Bangladesh Council of Scientific and Industrial Research, Dhaka 1205, Bangladesh; [email protected] 5 Department of Chemistry, University of Chittagong, Chittagong 4331, Bangladesh; [email protected] 6 Department of Chemistry, School of Science and Engineering, Tulane University, New Orleans, LA 70118, USA; [email protected] 7 Citation: Forid, M.S.; Rahman, M.A.; Department of Pharmacy, School of Medicine, University of Asia Pacific, 74/A, Green Road, Dhaka 1205, Bangladesh Aluwi, M.F.F.M.; Uddin, M.N.; Roy, 8 Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, T.G.; Mohanta, M.C.; Huq, A.M.; UPM Serdang, Serdang 43400, Selangor, Malaysia Amiruddin Zakaria, Z. * Correspondence: [email protected] (M.A.R.); [email protected] (A.M.H.); [email protected] (Z.A.Z.); Pharmacoinformatics and UPLC- Tel.: +880-3126-060011-4 (M.A.R.); +880-1906-790224 (A.M.H.); +60-1-9211-7090 (Z.A.Z.) QTOF/ESI-MS-Based Phytochemical Screening of Combretum indicum Abstract: This research investigated a UPLC-QTOF/ESI-MS-based phytochemical profiling of Com- against Oxidative Stress and bretum indicum leaf extract (CILEx), and explored its in vitro antioxidant and in vivo antidiabetic Alloxan-Induced Diabetes in effects in a Long–Evans rat model. -
Analgesic Effects of Methanolic Extracts of Anogeissus Latifolia Wall on Swiss Albino Mice
Available online a t www.pelagiaresearchlibrary.com Pelagia Research Library Der Pharmacia Sinica, 2013, 4(5):79-82 ISSN: 0976-8688 CODEN (USA): PSHIBD Analgesic effects of methanolic extracts of Anogeissus latifolia wall on swiss albino mice Vijusha M.*1, Shalini K.2, Veeresh K.2, Rajini A.2 and Hemamalini K.1 1Teegala Ram Reddy College of Pharmacy, Meerpet, Hyderabad, Andhra Pradesh, India 2Sree Dattha Institute of Pharmacy, Sheriguda, Ibrahimpatnam, Hyderabad, Andhra Pradesh, India _____________________________________________________________________________________________ ABSTRACT The main objective of my present research work is to find out the good pharmacological properties from medicinal plants with their preliminary phytochemical study and also to evaluate the analgesic activity of Anogeissus latifolia belongs to combretaceae family on mice by tail immersion, tail flick and eddy’s hot plate method. Dose was selected from the literature and the dose chosen for the study is 200 mg/kg, a small trial on acute toxicity was used to confirm the dose by using 2000 mg/kg, and there was no mortality found, so 1/10 th of this dose was chosen for analgesic activity. Normally herbal drugs are free of side effects and available in low cost. The methanolic extract of Anogeissus latifolia at 200 mg/kg showed a significant analgesic activity in tail immersion, tail flick, and hot plate model when compared to that of standard drug. Key words: Anogeissus latifolia, leaf, methanolic extract, tail immersion, tail flick and eddy’s hot plate model. _____________________________________________________________________________________________ INTRODUCTION In the history of medicine for the relief of pain many medicinal herbs has been used .natural products which contain many active principles are believed to have their potiential therapeutic value. -
ANTIDIABETIC POTENTIALS of LIPOSPHERES ENCAPSULATING Anogeissus Leiocarpus DC Guill & Perr ROOT BARK METHANOL EXTRACT
ANTIDIABETIC POTENTIALS OF LIPOSPHERES ENCAPSULATING Anogeissus leiocarpus DC Guill & Perr ROOT BARK METHANOL EXTRACT BY UCHECHI OKORO PG/M.PHARM/10/52392 A PROJECT PRESENTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF THE DEGREE OF MASTER OF PHARMACY (M.PHARM) IN PHYSICAL PHARMACEUTICS OF THE UNIVERSITY OF NIGERIA NSUKKA SUPERVISOR: PROF. A. A. ATTAMA DEPARTMENT OF PHARMACEUTICS, FACULTY OF PHARMACEUTICAL SCIENCES, UNIVERSITY OF NIGERIA, NSUKKA APRIL, 2014 i TITLE ANTIDIABETIC POTENTIALS OF LIPOSPHERES ENCAPSULATING Anogeissus leiocarpus DC Guill & Perr ROOT BARK METHANOL EXTRACT ii CERTIFICATION This is to certify that Uchechi Okoro, a postgraduate student in the Department of Pharmaceutics, with the registration number PG/M.Pharm./10/52392, has satisfactorily completed the requirements for the award of Master of Pharmacy (M. Pharm) degree in Physical Pharmaceutics. The work embodied in this project is original and has not been submitted in part or full for any other diploma or degree of this or any other University. Supervisor: Prof. A. A. Attama Head of Department: Prof. K.C. Oforkansi ………………………………. ………………………………….. Sign/Date Sign/Date iii DEDICATION This work is dedicated to God Almighty for all His mercies and grace; and to my parents for their continued support and love. iv ACKNOWLEDGMENT To God be the glory for all His wonderful works, His goodness, grace and mercies. My immense gratitude goes to my supervisor, Prof. A. A. Attama, one of a kind, for all his support, encouragement and guidance. I sincerely thank him for providing most of the materials and equipment used for this research work. I also, do really thank him for opening my eyes to the opportunities in the field of research. -
Abstract Background: the Dryland Area in Ethiopia Contributes Large Vegetation Resources
Page 1 of 46 Ecological and Floristic Study of Hirmi Forest, Tigray Region, Northern Ethiopia Mehari Girmay12*, Tamrat Bekele2, Sebsebe Demissew2, Ermias Lulekal2 *correspondence author: [email protected];[email protected] 1Environment and climate change directorate, Ministry of mining and petroleum of Ethiopia, P.O.Box: 486, Addis Ababa, Ethiopia. 2Department of Plant Biology and Biodiversity Management, Addis Ababa University, P.O. Box 3434, Addis Ababa, Ethiopia. Full list of author information is available at the end of the article. Abstract Background: The Dryland area in Ethiopia contributes large vegetation resources. However, the landmass has received less attention even if it has high ecological, environmental and economic importance. The present study was conducted in Hirmi forest, which is one of the dry forest in Northwestern, Ethiopia; to study the floristic composition, plant community types, community-environment relation, vegetation structure and regeneration status of the forest. Method: Vegetation and environmental data were collected from 80 sampling plots having equal size of 25m×25m were designated as the main plots. Within the main plot, five 2mx2m subplots were laid to record seedlings, saplings, and herbaceous species. Furthermore, within each subplot, soil samples were collected to analyze the relationship of edaphic parameters with the plant community. DBH, height, BA, density, vertical structure and frequency were computed. Floristic diversity and evenness were computed using Shannon diversity and Evenness indices. The plant community types and vegetation-environment relationships were analyzed using classification and ordination tools in R package (ver. 3.6.1), respectively. Result: A total of 171 vascular plant species belonging to 135 genera and 56 families were recorded. -
Anogeissus Leiocarpus (DC) Guill
Universal Journal of Environmental Research and Technolog y All Rights Reserved Euresian Publication © 2012 eISSN 2249 0256 Available Online at: www.environmentaljournal.org Volume 2, Issue 5: 383-392 Open Access Research Article Phytochemistry and Biological Activities of Extracts from Two Combretaceae Found in Burkina Faso: Anogeissus Leiocarpus (DC) Guill. and Perr . And Combretum Glutinosum Perr. Ex DC SORE Harouna 1* , HILOU Adama 1, SOMBIE Pierre Alexandre Eric Djifaby 1, COMPAORE Moussa 1, MEDA Roland, MILLOGO Jeanne 2 and NACOULMA Odile Germaine 1 1Laboratoire de Biochimie et de Chimie Appliquées (LABIOCA), UFR-SVT, Université de Ouagadougou, 09 BP 848 Ouagadougou 09, Burkina Faso 2Laboratoire de Biologie et Ecologie Végétale, UFR-SVT, Université de Ouagadougou, 09 BP 848 Ouagadougou 09, Burkina Faso *Corresponding Author : [email protected] Abstract: Many studies indicate that Combretaceae species are commonly used in Africa to treat various diseases. Nonetheless, no phytochemical and/or biological activity data are available from species found in Burkina Faso to secure their ethnomedicinal uses. In addition, drugs derived from these species, especially those of the genus Combretum, are sometimes the objects of adulteration by herbalists dealing in large cities of the country.This paper reports the pharmacognostic, phytochemical and biological activity of extracts from two of the most commonly used Combretaceae species found in Burkina Faso: Anogeissus leiocarpus (DC) Guill. and Perr . and Combretum glutinosum Perr. ex DC. Through the method of Ciulei, the characterization of the two drugs was made possible, and it was found that the phenolic compounds and flavonoids are the main active ingredients in the methanol extracts.