PA2GF PA2G5PA2GD PA21BPA2GEPA2GXPA2G3 Acyl chainAcyl chainremodelling remodelling of PI of PG Acyl chain remodelling of PS

PA24C

AcylAcyl chain chain remodelling remodelling of PCof PE GABA A receptor activation Neurotransmitter receptors and postsynaptic signal transmission GBRA2 GBRB3GBRA6GBRA5 PA2GA GBRA1GBRG2GBRB2GBRB1 GBRT GBRG3GBRA4GBRA3 PA24B Ligand-gated ion channel transport Acyl-CoA:dihydroxyacetonephosphateacyltransferase PPBI Hydrolysis of LPC Hydrolysis ofSynthesis LPE of PA LA Post-translational modification: synthesis of GPI-anchored proteins Catecholamine biosynthesis Plasmalogen biosynthesis GABAGBRR3 AGBRR2 (rho) receptor activation RNA Polymerase III Transcription Termination GBRR1 Creatine metabolism RNA Polymerase III AbortivePNMT AndDDC Retractive Initiation ReuptakeS6A11 of GABA PPBT DigestionPPBN S6A12SC6A7 Interaction between L1 and Ankyrins GLRA1 SC6A1 S6A13 SerotoninSodium/myo-inositol andInositol melatonin transporters cotransporter biosynthesis 2 GLRA2 KCRM FOLR2 KCNQ2 5HT3E5HT3D SC6A3 Astrocytic Glutamate-Glutamine Uptake And Metabolism 5HT3B EAA1 5HT3A5HT3C Na+/Cl- dependent neurotransmitter transportersDopamine clearance from the synaptic cleft SCN8AEAA2 Methylation of INMTTransportMeSeH forof inorganicexcretionSCNAASCN3ASCN2A cations/anions and amino acids/oligopeptidesGlycosyltransferase-likeO-linked glycosylation protein LARGE1 SC6A5SC6A9S6A15 SCN9ASCN4ASCN1ASCNBA SC6A6 SCN7ASCN5A Insulin effects increased synthesis of Xylulose-5-Phosphate SC6A2 TPH1 Potassium transport channels MOT2 Glutamine synthetaseCAC1I KCNJ1 Amino acid transport across the plasma membrane TKT EAA3 PRIO CAC1HCAC1G Proton-coupled monocarboxylate transport Glutamate Neurotransmitter Release Cycle Phase 3 - rapid repolarisationKCNQ1 Choline catabolism KCND3 NCAM1CAC1S interactions KCNH2 CarnitineBODG synthesis Voltage gated Potassium channels BHMT1 Reversal of alkylation damageFTOPhase by 1 DNA - inactivation dioxygenases of fast Na+ channels mRNA Editing:ABC3A C to U ConversionMethylenetetrahydrofolate dehydrogenase KCNE1 PAOX EBP S19A1 OAT PAOs oxidise polyamines to amines FOLH1 CAC1FCA2D1 Leukotriene receptors ADH1B ALDH2FADS2 6PGD NALD2 Signaling by plasma membrane FGFR1 fusions Ethanol oxidation ADH7AL1B1 PA24A Arachidonic acid metabolism ADHXADH6 ALKBH3 mediated reversal of alkylation damage VMAT2 tRNA processing in the nucleus Voltage-gated potassiumKCNA1 channel subunit beta-1 ALKB3 Formation of the Editosome 1-acylglycerol-3-phosphate O-acyltransferase alpha DDX1 Phase 2 - plateau phase Interconversion of polyamines KCNA3 ELOV5 MOT4MOT1 KCNA5 Linoleic acid (LA)ELOV1 metabolism BHMT2 Pyruvate metabolism Citric acid cycle (TCA cycle) KCNA4 ELOV2ELOV3 Amino acid synthesis and interconversion (transamination) Orexin and neuropeptides FF and QRFP bind to their respective receptors CLTR2 MDHM LT4R2LT4R1 GP183 CholesterolCholesterol biosynthesisbiosynthesis viavia lathosteroldesmosterolSerotoninSerotonin clearance NeurotransmitterSC6A4 from the Release synaptic Cycle cleft MetabolismXCT of folate and pterines Phase 0 - rapid depolarisation Synthesis of PIPs at the ER membrane CLTR1 GPR39 Pentose phosphate pathway (hexose monophosphate shunt) Acyl chain remodeling of CL FAAH1 GPR35 mRNA decay by 3' to 5' exoribonuclease DCPS Fatty-acid amide hydrolase 2 Metabolism of serotoninMitochondrial ABC transporters LGUL alpha-linolenic acid (ALA) metabolism ABCB6 PCFT FGFR1 Sulfur amino acid metabolism SGK3WNK2ASIC3 PI4KA QRFPR Hydroxycarboxylic acid-binding receptors SCNNBWNK1 NPFF2OX2R P2RY6P2Y10LPAR6GPR4GPR17P2Y receptors Glutathione synthesis and recycling SCNNASCNNGWNK3ASIC1 G6PC LPAR4 GP132 Class A/1 (Rhodopsin-like receptors) Gamma-glutamylcysteine synthetase CLCN3SGK2ANO1 ASNS F16P1G6PT1 NPFF1OX1RPLD2 ADH4ADH1G SAT1 Cell-extracellularMDHC matrix interactions Signaling by activated point mutants of FGFR1 HCAR2 LDHB Dopamine Neurotransmitter Release Cycle GCKR ADH1A LDHA Eicosanoid ligand-bindingLysosphingolipid receptors and LPA receptors ULK2GP139STK39CBX7NEK4 SDHA t(4;14) translocations of FGFR3 SignalingFGFR3 by mutantactivated receptor point mutants activation of FGFR3 P2RY1 AMDRAD54PAR12 Degradation of GABA ACM1ACM5 S22A9MYT1FUT9ERGDCLK2FUT7KPYR Synthesis of PG P2RY4P2Y14GPR55MTR1AMTR1B STK36SSH2TRYG1NEK5ANKK1ABHGA Norepinephrine Neurotransmitter Release Cycle GABT FGFR3b ligand binding and activation FGFR3cFGFR2c ligand ligand binding bindingHGFA and and activation activation HCAR1 PPM1DMRGX2SIK2 Voltage-gated N-type calcium channel alpha-1B subunit/Amyloid beta A4 precursor protein-binding family A member 1 FGFR1c Downstreamligand binding signaling and activation of activated FGFR1 LPAR3 GPR18CNR1SUCR1 HCAR3 ORAI3COQ8BMAST1ATX2CBPA1FCGRN ILK BRS3 LPAR5LPAR2 CNR2 B2LA1NR1I3TRYDTIE1 Synthesis of very long-chain fatty acyl-CoAs S40A1 SSDH FGFRL1 modulationFGFR3 of FGFR1 signaling GRM1 MTLRNMBR LPAR1S1PR2 GBRG1SENP7ABC3GNUAK2PIM2BMP6CDKL1 NRAM2 Stimuli-sensing channels FGFR1b ligand binding and activation HEPS GRM5 CCKARGHSR S1PR3 ProteinCyclin-dependent tyrosine phosphatase kinaseDUS22M3K12 2-associated receptorSENP6AminopeptidasePA2GC typeM3K10 proteinC-associated B2 protein FYV1 PKR1GRPREDNRACCKN OXER1S1PR4S1PR5 KLK6HDATAD5DYR1BXBP1 Enzymatic degradation of dopamine by COMT FGFR4FGFR2b ligand ligand binding binding and and activation activation PAR2 AssemblyAL1A1 of active LPL and LIPC lipaseTADBPFKBP3 CDKL5complexesDYRK3PASK Enzymatic degradation of DopamineDefective MTRby monoamine causes methylmalonic oxidase aciduriaL-type and amino homocystinuria acid transporter type cblG 1 PI4KB NTR2KISSRTRFRNTR1 LEG4GDF8PRUN1E2AK4ST17ACDK15LTKSHBGMMP26B3GT5 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Activated point mutants of FGFR2ATS13 Muscarinic acetylcholine receptors ACM4 5HT2A5HT2B HINT1Q9BPW0BRSK1SLC16A10ENTK NEK1 protein EDNRBUR2R 5HT2C Class C/3 (Metabotropic glutamate/pheromone receptors) 43 kDa receptor-associatedXPP1ST32BGSHRKLF10 proteinGP174TNR5 of the synapse DCMC Gluconeogenesis NMUR1 CASR PPICM3K13KCJ13ST38LICKMAST4RECQ1 Abacavir metabolism NMUR2 MAST2GRB2SEPRPRKXTGM3MAST3 ADAL P4K2B BKRB1 SCRB1OXSR1EBPLAHSA1PIN4SRPK1CBG Guanylate kinase DefectiveRegulation TPR may conferof Glucokinase susceptibility by Glucokinase towards thyroid Regulatory papillary Protein carcinoma (TPC) BKRB2MCHR2 G-proteinRBBP9 coupledABC3FPTPRMSGMR1 receptorSTK33 12 Metal ion SLC transporters GCYB2 MCOLN3 protein O-glycosylation of TSR domain-containing proteins Phospholipase C-mediated cascade: FGFR1 GRM7 MRGX1BRSK2CELA1MYLK4DCLK3DPP9GBRDGP182CLK3SIR2 GCYA3GCYA2 TRPV1TRPA1TRPM8 Defective B3GALTL causes Peters-plus syndrome (PpS) Phospholipase C-mediated cascade; FGFR2 Signaling by MST1 CCRL2 GRM3 KC1AL GBRPQORDPOG1HMDH Catabolism ofHypusine glucuronate synthesis to xylulose-5-phosphate from eIF5A-lysine Iron uptake and transport GCYB1 TRPV4 CAC1D G alpha (q) signallingCX3C1 events GRM8 GHRLMPEG1CLK1DUS26PTN7MYLK2STK16M4K5UNG Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB TRPM6TRPV3 CAC1C ACM3 GRM4 Cyclin-dependentChymotrypsin-likeMucosal kinaseProteasomeNMD3A addressin 2-associated protease assemblycellPRDX5 adhesionM3K6 protein CTRL-1 chaperone molecule-1 1 3 DeoxyhypusineDHSO synthase Potassium-transportingATP4A ATPaseTRPV6 alpha chain 2 P2RY2SSR1 GRM6GRM2 KCC1DMembrane-associatedKDM4ECDK14TNI3KCDK18TLK2COQ8A guanylatePI4KA/PI4KAP2MAKGPR52 HIPK3kinase-relatedFOLC 3 COMT ATP4B betaKlotho-mediatedSynthesis ligand of PIPs binding at the early endosome membrane FGF1 FGF4PTPM1 OXYRGALR2OPRX HKDC1KCC1GINSRRBis(5'-adenosyl)-triphosphataseGlyoxalaseNEK11CLK2 ELF3II PABP4GP142LEPRMAONCDKL2PEPDCCNB3CTDS1 AOFA Phospholipase C-mediated cascade; FGFR3 GPER1SSR5SSR4 MRCKANR2E3MELKBMP2KGP151PHF23ST17BCASP5 ST32CM3K2TYRO3SLK M4K3 FGFR4 mutant receptor activation MET Receptor Activation NK3RNK2R NPBW1APJ HRH1 BACE2SBK1CDKL3TDTM3K20GPR34TP4A1RNAS1M4K1MARK1STK35P4HTMMBTD1RIPK4SO3A1ACVR1ST32APPAC RIR1 LDLDCTD clearance Phospholipase C-mediated cascade; FGFR4 Peptide ligand-binding receptorsNPY5RAGTR2APEL 5HT1F5HT1B BAZ2BGRK4TOPKTM11DMultidrugNMD3BPGTB1SNRKTHBGSIR7 resistanceKC1G3BRD3SRPK3TLK1 associated protein Beta-oxidationPeroxisomal of very long carnitine chain O-octanoyltransferase fatty acids METH KTHY NPY1RSSR2 5HT1E5HT5A Human KLK4immunodeficiencyBRD4M4K2ThreonineNEK3CNCGERBB4SRR aspartaseLEG8 virusCDK3ROS1 1 typeDNAS1HUNK ACK1I NR5A2enhancer-bindingDYRK4 protein 1 KCY GLSK RYR1 Neurexins and neuroligins FFAR2FFAR3 NPY4RNPY2RGALR3GALR1CCR9CCR8 5HT1ASerotonin receptors ANM8AMPLMPP8PRP4BDGAT1MBNL1 DUTproteinNPCL1VRK2NISCHSMBT1CDK17WEE2AURKC KAD2 FKB1B CXCR5 5HT1D PIM3GRAKPPIDPTPREDEFME2AK1PTPRR PTN5PAR15PCSK7TNK1TP4A3 DHCR7 HPRT Basigin interactions PLCB FGF22 OPRK CXCR3CCR4ACKR3 Phospholipid transferTESK2OGAProteinPCSK4 LEG7proteinTSSK2CLK4 phosphataseHIPK4PEPCSBK3KCC1ADPP8S10A4 2ANR0B1 regulatory subunit B' AMPADA deaminase 2 TRPC5 PLPL9 FGF2 ThromboxanePAR4 signalling through TP receptor CCR3 KKCC2AspartylGPR88HASP aminopeptidasePPCELMBL4SRPK2ERBB3B2CL2EPORTMPS4NIM1 AOFB PPT1 ADK TWIK related potassium channel (TREK) PF2RPE2R1 FUT4MTAP2LRC59TGM2NF2L2CBX1NR1I2PDE6CSTK25ACHBPERFM3K4 S22A2 N-glycan trimming and elongation in the cis-Golgi Synthesis of PIPs at the late endosome membrane NF-kappa-B-repressingM3K19TSSK1MYO3BMethyl-CpG-bindingPLAPOGRL1 factorMK15DCLK1MRCKBTRXR3 protein 2 Beta-oxidation of pristanoyl-CoA S22A1SCD5 MGAT1 AT1B1AT1B2 V1BRV1AR P2Y12 LactoperoxidaseSTK38DUSTYTAOK2FUT6MARK2LMBL3MKNK2BIRC8ACH10KC1G1PARP3 Nitric oxide stimulates guanylate cyclase AT1B3FGFR2 Synthesis of GDP-mannose MRCKGGBRECISD1PairedALKTTKPMP22 box proteinM3K9PTPRG Pax-8 SAHH Fructose biosynthesis ABCG2 P4K2A RGS12 MYO3AFUT5PPIFTAOK3ANPRCSIK3CDK16 ATS5 PLD1 SHC-mediatedPI-3K cascade:FGFR2cascade:FGFR2 RONECE1 HRH3 Membrane metallo-endopeptidase-likeM3K15MYLK3 1 PDGFA ATS1 Synthesis of PIPs at the Golgi membrane UroporphyrinogenEndothelin-converting decarboxylaseGNAQ enzymeMPI 2 RGS8 HRH4 AK1A1 DDR2DDR1 ATS4 ATF4 activates SHC-mediatedPI-3K cascade:FGFR1 cascade:FGFR1 Uroporphyrinogen-IIIPRLHR synthase Ion transport by P-type ATPases TRP channels FGF7 PAR1 Heme biosynthesis PMM2 RA biosynthesis pathway NU4M SHC-mediatedADPPI-3K signalling cascade:FGFR4 cascade:FGFR4 through P2Y purinoceptor 1 HEM6 Chemokine receptors bind chemokines PRSS8 FGFR4 G alpha (i) signalling events Histamine receptors AL1A2 TRAP1 AT1A4AT1A3 KLK8CASPE Tachykinin receptorsFRS-mediated bind tachykinins FGFR2 signaling FreePPOX fatty acid receptors KCNK2 QCR7 ATNGAT1A1 ST14 PI-3K cascade:FGFR3 PE2R3 Cellular retinoic acid-binding protein I Complex I biogenesis AT1A2 KLK14 CSKP SHC-mediated cascade:FGFR3 MCHR1 AA3R PD2R2 DRD4 AL1A3 Fructose catabolism Purine salvage TGM1KLK5 FRS-mediated FGFR1 signaling AA1R DRD3DRD2 Respiratory electron transport InlB-mediated entry of Listeria monocytogenes into host cell CXCR4 P2Y11 Assembly of active LPL and LIPC lipase complexesNOS1 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1 NMDE1NMDE3 FK506 binding protein 14 SignalingFRS-mediated by FGFR2 FGFR4 in disease signaling SignalingWNT mediated by FGFR2 activation fusions of DVL NMDE4 P3C2GCA2D2 Signaling by FGFR3 point mutants in cancer LDL clearance FRS-mediatedSignaling FGFR3 by signaling FGFR1 in disease Vasopressin-like receptors Signaling by FGFR2 amplification mutants Non-integrin membrane-ECM interactions Localization of thephospho-PLA2 PINCH-ILK-PARVIN pathway complex to focal adhesions TA2R ALDR EPH-ephrin mediated repulsion of cells Integration of provirus VLDL clearance MET receptor recycling CCL5 RL3R2RL3R1 Interconversion of nucleotide di- and triphosphates APOBEC3GAssembly mediated Of Theresistance HIV Virion to HIV-1 infection Negative regulation of FGFR2 signaling S1PR1 CCR1 TWIK-releated acid-sensitive K+ channel (TASK) UncoatingPlus-strandMinus-strand of theDNA DNA HIV synthesis synthesisVirion PTN2 Role of second messengers in netrin-1 signaling CXCL2 SSR3 Synthesis of UDP-N-acetyl-glucosamine PHF8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretionNPSR1NPS DHB4 FADS1 AntimicrobialKDM5CKDM4D peptides FFAR1 KCNK3KCNK9 KDM5AKDM2A Formation of the cornified envelope ANGP1 GABR1 METK2 Negative regulationTIE2 of FGFR1 signalingPI3K Cascade CCR5 Defective AVP causes neurohypophyseal diabetes insipidus (NDI) GABR2 Metabolism of ingested SeMet, Sec, MeSec into H2Se FattyChREBP acyl-CoA activates biosynthesis metabolic expressionEpididymis-specific alpha-mannosidase Ras activationDMPK uopn Ca2+ infux through NMDA receptorPK3C3 Prostanoid ligand receptorsDopamine receptors ST1E1 TPMT GSTM2 Ion influx/efflux at host-pathogen interface Unblocking of NMDA receptor, glutamate binding and activation NMDZ1 Negative regulation of FGFR4 signaling Cation-coupled ChlorideGNRHR cotransporters ST1A1 GSTA1 MET activates PTPN11 Signaling by FGFR3 fusions in cancer S12A2 GPBAR Phase 4 - resting membrane potential CP26A KHK GSTM1 Vacuolar ATP synthase subunit B, kidney isoform NMDE2 OPRD SYFM SYTMCCR6 Ion channel transport VATB2 TNNI3 Protein-beta-aspartate methyltransferase NOX3NOX1 KS6B1 C3ARC5AR1MET activates PI3K/AKT signaling Glycerophospholipid catabolism Synaptic adhesion-like molecules Negative regulationEF2KANGT of MET activity KCNB1ENPP6 GABA B receptor activation FA9 FA10G6PD Negative regulation of FGFR3 signaling Acetylcholine regulates insulin secretion Adenosine P1 receptors S27A4 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 THRB MET MET activates RAS Presynapticsignaling function of Kainate receptorsGASR Defective HLCS causes multiple carboxylase deficiency Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Signaling by FGFR4 in disease Pregnenolone biosynthesis Vacuolar ATP synthase subunit S1 NAGA KAT1 Constitutive Signaling by Aberrant PI3K in Cancer CXCR1 EPM2A NRAM1ROS, RNS production in phagocytes MAGKCC2BKCC2G FPR2 CXCR2 Glycogen synthesis ELOV6 Striated Muscle Contraction Abacavir transmembraneTransferrinSMN transport endocytosis and recyclingRemoval of aminoterminal propeptidesKLKB1 from gamma-carboxylated CBPB2proteins CREB phosphorylationDLG4 CFAB through the activation of CaMKII PTAFR CCR2 MyoclonicTransport epilepsy of nucleosides of Lafora and free purine and pyrimidine bases across the plasma membrane LCATLIPE Insulin receptor recycling ActivationKCC2D of C3 and C5 P3C2B G beta:gamma signalling through PLC beta Methylation Tryptophan catabolism S22A3 Gamma-carboxylation of proteinMMP17 precursorsFA11 Regulation of Complement cascade METRAF/MAPMET activates interacts kinase STAT3 with PGFRAcascadeTNS proteins PTN13 SOS-mediated signalling HXK4 ADA1BADA1A GYS1 S29A1S28A2 Lysosomal oligosaccharide catabolism TRYB1FA12 NOS2Signaling by FGFR2 IIIa TM PGFRB Tie2 Signaling GRK5 S28A1 DHRS9 CTRC MMP16 Intrinsic Pathway of Fibrin Clot Formation Signaling by PDGF HGF PI3K events in ERBB4 signaling ADA1D Relaxin receptors S28A3Regulation of cytoskeletal remodeling andTESK1 cell spreading by IPP complex components Glutathione conjugation Extrinsic Pathway of Fibrin Clot Formation SAMPSNCAP PPIA SHC1 events in ERBB4 signaling SDF1 PEPA5 Mitochondrial tRNA aminoacylation BACE1 Sodium/calcium exchangerIon homeostasis 1 OPSR PDGFB GRB2 eventsSHC1 eventsin EGFR in EGFRsignaling signalingENOA OPRM MSHR GlycogenGlycogen storage storage disease disease type type IV 0XV (GBE1)(muscle (GYG1) GYS1) ACE SYUA INSR LMNA G3P 4EBP1 MC5R 5HT6R Cytosolic sulfonation of small molecules TNNC1 CTRB1 CBPB1ACE2 NrCAMPCKGC interactions SHC-related events triggeredP3C2A by IGF1RThrombin signalling through proteinase activated receptors (PARs) TPIS MC3RMC4R 5HT4R TRY1Aminopeptidase A TRPC3TRPC6 Insulin receptorRAS signaling signalling downstream cascade ofSon IL8NF1 of loss-of-function sevenless homolog variants 1 Adrenaline signalling5HT7R through Alpha-2 adrenergic receptor TSPOTNNT2 RENI GRIA4 KCC2AGRIK3 EGFR interacts with phospholipase C-gamma FFAR4 Adrenaline,noradrenalinePLCB3 inhibits insulin secretion Biotin transport and metabolism Protein repair IGF1R CO3 GRB7 eventsGRP3 in ERBB2 signalingPI51A GRB7 Phospholipase C-beta-1 LGI-ADAM interactionsPROCGRIA3 GRB2PI3K events eventsDownstream in ERBB2in ERBB2Binding signal signaling signaling transduction and entry of HIV virion ADA2A ACLY HDMs demethylate histonesTPAF13B Alternative complementDAP12 interactions activation ITA3 PLCG1 eventsTight junction in ERBB2 interactions signaling KCNJ2KCNJ4 Neurotransmitter release cycle HNMT Common Pathway of Fibrin Clot Formation RET ADA2C NAAA HDL remodeling Reduction of cytosolic Ca++ levels Signaling by cytosolic FGFR1 fusion mutants PK3CA Opioid Signalling DHB7 I23O1 S22A4S22AG Metabolism of Angiotensinogen to Angiotensins BCR Transport of the SLBP DependantSurfactant Mature metabolism mRNA ADA2B Vitamins KMO Neurotransmitter clearance Synthesis and processing CMA1of ENV and VPU IRS activationCCL2 PLCG1 Transport of Mature mRNA Derived from anADP Intronless signalling Transcript through P2Y purinoceptorHRH2 12 T23O NOX5 Trafficking of AMPA receptors RHO GTPases ActivateKDM7A NADPH Oxidases GRB10 SHC-transforming proteinNephrin 1 family interactions Synthesis, secretion, and inactivation of Glucose-dependent InsulinotropicInhibition of PolypeptidevoltageClassical gated (GIP)Kir Ca2+ channels channels via Gbeta/gamma subunits ACODI23O2ACACA TRXR2 ADAM9 Signaling by ERBB4 Prolactin receptor signaling Transport of the SLBP independent Mature mRNA FAS Organic cation transport TF THIOMSODE IRS-related events triggered by IGF1R Synthesis of PIPs in the nucleus PTPRA RASH AGTR1 AA2BR Activation of G protein gated Potassium channels Transport of fatty acids CETP Cobalamin (Cbl, vitamin B12) NOX4transport and metabolism Signaling by TypeMMP15 1 Insulin-likeKLK7 Growth Factor 1 Receptor (IGF1R)TRPM2 P85A ACM2 ActivationEF1A2 of AMPA receptorsMMP14MMP11 AmyloidELNE fiber formation POU5F1 (OCT4), SOX2,HEM2 NANOG activateEGFR genes Transactivationrelated to proliferationPRLR by Gastrin GAB1 signalosomeCostimulation by the CD28 family Inhibition of PKR MMP1ANT3 PTN12 STA5B Queuine tRNA-ribosyltransferase RGS4Adrenoceptors PD2R KCNN2 RIR2BActivation of MatrixMMP10 Metalloproteinases Signaling by Insulin receptor KITFPR1PTN11 PE2R2PE2R4 DRD1 KCNN4KCNN1 AMPD3 Budding and maturation of HIV virion ConstitutiveSynthesis Signaling of PIPs by Ligand-Responsiveat the plasma membrane EGFRLYPA2Gamma Cancer carboxylation, Variants hypusine formationICMT and arylsulfatase activation DRD5 Glyoxylate metabolism and glycine degradation KCNN3 Ca2+ activatedDCK K+ channels CATG The retinoid cycleOpsins in cones (daylight vision) NK1R RASK GP119ACTHRDPP4 WNT5A-dependent internalization of FZD4 VKGC GRIA2 Signal attenuation HydroxyacidOXDD oxidase 1 MetabolismMetabolism of ingested of ingested H2SeO4 MeSeO2HFA7 and H2SeO3 into MeSeH into H2Se PCSK6 HYOU1 Signaling by LeptinConstitutive Signaling by EGFRvIII SHIP2 OXDA Retinoid cycle disease events MMP12TMPS6 PLMN TREM1 EDAR COX2COX1 TRY3 CRCM1ORAI2 HBEGF CDC37 Interleukin-7Signalling signaling to RAS Glutaminyl-tRNASYK synthetase TRY2 IGF1 Sodium/Calcium exchangers PLF4 EGFR Presynaptic depolarization and calciumInterleukin channel receptor opening SHC signaling AA2AR HCN channels Histidine catabolism AADAT PRTN3 InhibitionMATK of Signaling by Overexpressed EGFR SHC1FERSTA5A eventsInterleukin-15 in ERBB2 signaling signaling Role of phospholipidsP55G in phagocytosis RXFP1 HCN1 STS HEXA Detoxification of Reactive Oxygen Species GRIA1 PCSK5 ERBB2 IL2RB Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent bindingRXFP2 to 43S HCN4 CP27BCP24A CS/DSThe activationdegradation of arylsulfatases GSTO1 MMP7 FormylPI5P, peptide PP2A receptors and IER3 bind Regulate formyl PI3K/AKTpeptidesActivation and Signalingof manyRAS inother B cells ligands HCN2 SIAT1 GSTA2 TTHY MMP13 FURIN PI42API42C Regulation of signaling by NODAL VGFR3 ACACB ASAH2ENPP7GBA3 PNPH GSTP1 IL6RBPI42B GP1b-IX-V activationPK3CD signalling PI2R TerminationCEGTKeratan of O-glycan sulfate biosynthesisdegradation POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation Toll Like Receptor 9 (TLR9) Cascade ASMGBA2 DYR KLK1 NOSIP mediated eNOS traffickingMMP3 NGF processing SIGL7 Downregulation of ERBB2 signaling Interleukin-10 signaling JAK3 Synthesis, secretion, andE2AK2 inactivation of Glucagon-like Peptide-1 (GLP-1) KCNJ5 The canonical retinoid cycle in rods (twilight vision) N-Glycan antennae elongation S10AAActivation of Ca-permeable Kainate Receptor TRFE SH21A Interleukin-35 Signalling Interleukin-3, 5 and GM-CSF signaling KCNJ9 NEUR2NEUR3 Type DegradationI hemidesmosome of the extracellular assembly matrix IL-6-typeInterleukin-6 cytokinemTORC1-mediated family receptor signaling ligand signallinginteractions L1CAM interactions Aminoacyl-tRNAGLRADRB1KCNJ6 synthetase ER Quality ControlMA1B1 Compartment (ERQC) HyaluronanSIAT6 uptake and degradation ATG4BMethionineMANBA salvage pathway Laminin interactions MET activates RAP1 and RAC1 tRNA modification in the nucleus and cytosol KCNJ3ADRB3 SeMet incorporation into proteins LYAM2 ITB7 Platelet Aggregation (Plug Formation)STAT1 PLGF TYSYRIR2 LDL remodeling CollagenMMP8 degradationPCP Glycophorin-AMERTK Fibronectin matrix formationMET activates PTK2 signaling Interleukin-2 family signaling Hormone ligand-binding receptors DHB3 Interaction With The Zona Pellucida SELPL Interleukin-19,20,22,24,26,28 and 29 signaling PK3CBP85B G-protein activation NANP Sialic acidSIA4A metabolism HEXB Pre-NOTCH Processing in Golgi CD2 Elastic fibre formation ERBB2 Regulates Cell Motility PK3CG PLC beta mediated events Heme degradation NEUR4 Glycosphingolipid metabolism Assembly of active LPL and LIPCLEG1 lipase complexes FINCSyndecan interactions VWFSignaling by SCF-KIT PI3R5 BBSome-mediated cargo-targeting to cilium Activation and oligomerizationBAK of BAK protein MMP2 F13A Extracellular matrix organizationGRB2:SOS provides linkage to MAPK signaling for Integrins Galactoside 3(4)-L-fucosyltransferaseFUT8 ICAM1 UD11UD14 BGAL snRNP Assembly MGAT2 Regulation of Insulin-like GrowthDissolution Factor (IGF) of Fibrin transportAMPN Clot and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) PIP3JAK1 activates AKT signaling SignalLEG9 regulatory protein family interactions Leucyl-tRNAArginyl-tRNA synthetase synthetase Lysine catabolism FA8 CY24B PTN1 KSR2 Regulation of signaling by CBL HS-GAG degradation NEP CD44 C1S Integrin cell surface interactions IL2 TEC GLUC FSHR CytosolicGIP tRNA aminoacylation Cholesterol biosynthesisERG24FPPS Telomere C-strandSL9A1 synthesis initiation BMP4 ImmunoregulatoryC1R interactions between a LymphoidITB1 and a non-Lymphoid cell Signaling by BRAF and RAFNetrin fusions mediated repulsion signalsPI3K/AKT activation KPCE IF4E GNAI1 LSHRTSHR Isoleucyl-tRNASYMC synthetase Squalene monooxygenaseGGPPS Early Phase of HIV Life Cycle Cerebroside-sulfatase GRIK4 KDM4C MMP25 CPNS1 MAPK1ITA2ACV1B (ERK2) activation VEGF binds to VEGFR leading to receptorPLC-gamma1 dimerizationPhospholipase signalling C-delta-1 VTDB B4GT1AttachmentTRXR1 of GPI anchor to uPAR Eukaryotic Translation Elongation CFAD Elevation of cytosolic Ca2+ levels RET signaling rRNABeta modification defensins in the nucleus and cytosol GNAI3 ERG7Vitamin B5 (pantothenate) metabolism GRIK5 LYAM3 VCAM1 ITA5 CD22 Signaling by RAS mutants UD16UD18 UD2B4UD17 GuanineDNPH1DNA deaminase replication initiation KLK2 SGK1 MMP9 VEGF ligand-receptor interactions Paradoxical activation ofCAC1B RAF signaling by kinase inactive BRAF G alpha (12/13) signalling events V2R GlucuronidationUDB15UD13UDB17 HPGDS NEUR1 BGLR Lysosomal glycogen catabolism MTAP SODC NOS3 ITB6 TYK2Growth hormone receptorp130CasSignaling signaling linkage by BMP to MAPK MAP2Ksignaling and for MAPKintegrins activation DAP12 signaling UD110UDB10UDB28UD2B7 S22A5 Keratan sulfate biosynthesisPYGM Alpha-defensinsCell surface interactions at the vascularINSERBB2 wall Activates PTK6 Signaling DAG and IP3VGFR1 signaling RET4 PHKG2KPB2 FA5 Trafficking of GluR2-containing AMPA receptors IL6RA Signaling by moderate kinase activity BRAF mutants Frs2-mediated activation SO2A1 PHKG1KPB1 ReactionsGRIK1 specific to the complex N-glycan synthesis pathway Post-translational protein phosphorylation KCMA1 AVR2ABMP2 SignalingPI51C by high-kinase activity BRAF mutants Vitamin D (calciferol) metabolism SO4A1 KPBB GlycogenGRIK2 breakdown (glycogenolysis) UPAR PO5F1 STAT6Regulation of IFNG signalingInterferon gamma signalingAVR2B ITB3FIBB RegulationMARK3 ofM3K11 DefectiveKIT signaling ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) THIO ITA4 STAT3 ARAF SO2B1Purine catabolism MBTP1 PSN1 LYAM1 BMR1BBMPR2PTN6 Protein phosphatase 2C beta G alpha (s) signalling events Sodium/Proton exchangers SO1C1 LIPC CAN1 PLEC EGFRJAK2 downregulationPlateletRegulation Adhesion of IFNA to exposed signaling collagen PECAM1 interactionsCSKFAK2 DefectiveDefective SLCO1B3 SLCO1B1 causes causes hyperbilirubinemia, hyperbilirubinemia, Rotor Rotor type type (HBLRR) (HBLRR) ATAD2 AntigenG activatesbeta:gammaBMR1AACVL1 B Cell signalling Receptor through (BCR) PI3Kgamma leading to generation of second messengers Prostacyclin signalling through prostacyclin receptor PTPRF ASAH1 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors RAF1 Role of LAT2/NTAL/LAB on calcium mobilizationNTRK1 ENPP3 AGALASF1A Neutral sphingomyelinase ITAL MoleculesFLT3 associated with elastic fibres CD22 mediated BCRCAC1ASynthesis regulation ofRAP1A IP3 and IP4 in the cytosol ENPP2 NADPH regeneration UROK KDM6B IL6 TGFB2 CSF1R ITA1 EPHA1ReelinITPR3 signalling pathway NGF-independant TRKA activation Abnormal conversionActivation of of2-oxoglutarate Na-permeable kainate to 2-hydroxyglutaratereceptors PCSK9HPSE Insulin-like growth factor binding protein 3 ITB5 TPOR NCAM signaling for neurite out-growthMP2K2KPCI BRAF IF4HValyl-tRNA synthetase 2 Glucagon-type ligand receptors XDH LFA3Initial triggering of complementSynthesis, secretion, and deacylation of GhrelinITAV ITPR1 SYTC ST2A1 LYAG Classical antibody-mediated complement activationInterleukin-12 family signalingRegulation ofTPO gene expression in ITA2Bbeta cells LDL clearance CREB3 factors activate genesKDM4A Assembly of collagen fibrils and other multimeric structures OLR1 Other semaphorin interactions TS101 Signalling to STAT3 ARMS-mediated activation IF4A1 PACA VIPVIPR1 peptides DHB1 Transport of organic anions SOAT1 CYB5 FUCO Platelet degranulation Tyrosyl-tRNA synthetase PACR GLP2R ALBULICHNPC1Sodium-dependent vitaminIDHC C transporter 2 BrainLactose glycogen synthesisPYGL Signaling by EGFR BMX Histidyl-tRNA synthetase GIPRSCTR ENPP1 NCEH1SOAT2 CaM pathway Other interleukin signaling Negative feedback regulation of MAPK pathway Signalling to p38 via RIT and RIN VIPR2 Glycogen debranching enzymeScavengingMidkine by Class A Receptors MIF P2RX2P2RX5 ECM proteoglycans Effects of PIP2 hydrolysis PDE8A GHRHR S27A1 KLK3 CCL11MCL1 P2X purinoceptor 6 MUSK SignalingSRMS by ERBB2 GRK6PDE7B Unwinding of DNA Chylomicron clearance PIM1 P2RX1 P2RX3Axonal growth inhibitionRNA Polymerase(RHOA activation) I Promoter Opening GPVI-mediated activation cascade CRFR2TRKA activation by NGF Deadenylation of mRNA MGMT-mediated MGMTDNA damage reversalPDE8B ENPLPDCD4 A1AG1 P2RX4 Endosomal Sorting Complex Required For Transport (ESCRT)FYN PARG VitaminBMP1 C (ascorbate) metabolism ANXA2 IFNG Platelet homeostasis Neurophilin interactions with VEGF and VEGFR Activation of gene expression byMitochondrial SREBF (SREBP) carnitine/acylcarnitine carrier protein SO4C1 Calmodulin Integrin alphaIIbFAK1 beta3 signalingDiacylglycerol kinaseYES epsilon ARBK1 GLP1R Retinoid metabolism disease events MAPK3 (ERK1) activation MK03 Sema4D mediated inhibition of cell attachment and migrationDiacylglycerol kinase delta EPHB2 PDE7A Cargo concentration Apolipoproteinin theCATZ ER B-100 ActivationImmunoglobulin of BIM and epsilon translocation Fc receptor to mitochondria MP2K1ISG15 antiviral mechanismVGFR2 KPCL Deposition of new CENPA-containing nucleosomes at the centromere ITB2 HCK G alpha (z) signalling events Cytosolic iron-sulfurTFAP2A cluster acts assembly as a transcriptionalNuclear repressor import ofduring Rev retinoicprotein acid induced cell differentiation Regulation of cholesterol biosynthesis by SREBP (SREBF) EPHA7EPHA8EPH-Ephrin signaling TAU CREB phosphorylation through theTNFs activation bind their of RasphysiologicalAsparagine receptors N-linkedINAR1VEGFR2 glycosylation mediated cellRAF proliferation activation Rho/Rac guanine nucleotide exchangeEPHA5 factorEPHA3 GNAO Vitamin B2 (riboflavin)FDFT metabolism MA2A1 Scavenging by Class H ReceptorsLDLR Breakdown of theActivationInterleukin-4 nuclear lamina of BMFand 13 and signaling translocation to mitochondria CD28 co-stimulationEPHA6 Ribosomal scanning and start codon recognition UHRF1 CrosslinkingAnchoring fibril of collagen formation fibrils Chylomicron remodeling VLDL clearanceACES Synthesis of diphthamide-EEF2 Ceramide signalling CHL1 interactions EPHA2 TXK FEN1 MEP50 Butyrophilin (BTN) family interactions Gene and protein expressionPPAP by JAK-STATScavenging signaling by DDAH1Classafter Interleukin-12F Receptors stimulationCross-presentationSignalingVEGFAP2RX7 of byparticulate NODAL exogenous antigens (phagosomes) SHIP1TIAM1 EPHA4 GTP hydrolysisPDE11 and joining of the 60S ribosomal subunit AK1C3 Pyrimidine salvage VLDL assembly DLK1 CHLE DDX3XSTK10 CNOT7 MK01 Regulation of insulin secretion FCERI mediated Ca+2 mobilization PDE2A RAMP1CALCA Retinoid metabolism and transport CDD Chylomicron assemblyEF-hand calcium-binding domain-containingKPYMQPCT protein 4BLYPA1 PAFAMBOA4 KPCA EPHB-mediated forward signaling PDE3APDE10 GNAS2 ADML DPOLM MTP RHEBRPTOR PTPRB HSF1-dependent transactivation ITAM PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases ARBK2 ADCY6Glucagon signaling in metabolic regulation NPMDNM3L ADA10 CAN2 DPP2 Platelet sensitization by LDL RAMP2CALRLCALCRRAMP3 HDR through MMEJ (alt-NHEJ) DPOLL PGH2 CATD PERM PRPK ADCY5 ADM2 POLI Phosphate bond hydrolysisTYDP2 by NTPDase proteins ATF6 (ATF6-alpha) activates chaperones Uptake and function ofSpry anthrax regulationEPH-ephrin toxins of FGF mediated signaling FasL/repulsion CD95L of cellssignaling LCK EPHB1 Adenylate cyclase inhibitory pathway TYDP1 ENTP3 Glycoprotein hormonesGLHA PTK6 Down-RegulationFGR CLEC7AFCGR (Dectin-1) activation inducesKSYK NFATEPHB3 EPHB6activation PDE1B Calcitonin-like ligand receptors SO1B1 ENTP2ENTP8 TetrahydrobiopterinThyroxine (BH4) biosynthesis synthesis, recycling, salvage and regulation MKNK1 Calmodulin induced events EPHA-mediated growthEPHB4 conecGMP collapse effects PDE1A Translation initiation complex formation UD19CP51A SO1B3SO1A2 ENTP1ENTP4 LIPL The AIM2 inflammasome ARRB1Negative regulation of MAPK pathwayLYN NTRK2 DPOLA Neutrophil degranulation Signaling CLC4Cby Activin SEMA3A-Plexin repulsion signaling by inhibitingDectin-2 Integrin family adhesion Glucagon-like Peptide-1L13a-mediated (GLP1) regulates translational insulin silencing secretion of Ceruloplasmin expression UBP1 Uridine-cytidine kinase 2 mTORCATK signalling PTPRC NGF Rho-GTPase-activating protein 3 ADCY4 UCK1 GLCM PPGB Macroautophagy Polymerase switchingPolymerase on the switching C-strand of the telomere KITM ATF6 (ATF6-alpha) activates chaperonePDIA1 genes GTR1 ActivationPhenylalanine of CaMK and tyrosine IV catabolismeNOS activation Signal transduction by L1 PD-1 signaling Glycolysis ADCY2ADCY7 Processive synthesis on the lagging strand AK1BA The IPAF inflammasome Cargo recognition for clathrin-mediated endocytosis ROCK2RPGF4RPGF3 Alpha-oxidation of phytanate AMPK inhibits chREBPPPM1A transcriptionalSTK11B3GN3 activationNOTCH2 activity Activation and Transmission of Signal to the Nucleus Uptake and function of Clathrin-mediatedSmooth Muscle endocytosis ContractionSTK24 RAF-independent MAPK1/3KPCD activationRho GTPase cycle NFAC1 F263 AdenylateADCY9 cyclase activating pathway PGES2 PAI1 COF1NFG and proNGFNRAGE binds signalsto p75NTR death through JNK Processive synthesis on the C-strandRemoval of the of thetelomere Flap Intermediate POLB-DependentUPP1 Long Patch Base Excision Repair RHO GTPasesKGP2 CTRO activate CIT HXK1 ADCY8 Telomere C-strandEstrogen (Lagging biosynthesisStrand)DHB2 SynthesisDNLI1 TYPH Import of palmitoyl-CoA into the mitochondrial matrix MissplicedNADH-cytochrome LRP5 mutants b5 reductase have enhanced beta-catenin-dependent signaling GRP1 RS6 ADCY1 S27A2 KITH TP53 Regulates Metabolic Genes RUNX3 Regulates Immune Response and Cell Migration A4 FES Cam-PDE 1 activation PDE3B TAAR1 Removal of the Flap Intermediate from the C-strand AAPK1 COPII (Coat Protein 2) Mediated Vesicle Transport PTK6EF2 Activates STAT3 AAK1 DUS1ROCK1 PLCG2 ADCY3 Translesion synthesis by POLI LX15B Formation of Senescence-Associated Heterochromatin Foci (SAHF) STAT6-mediated induction of chemokines NOSTRIN mediated eNOS trafficking Apoptotic executionNRP1 phase Dual specificity protein phosphataseTRAIL 5 signaling Proton/oligopeptideS15A1 cotransporters SynthesisCollagen of 15-eicosatetraenoic biosynthesis and acidmodifying derivatives enzymesConstitutive Signaling by NOTCH1 HD DomainActivated Mutants NOTCH1 Transmits Signal to the NucleusM3K5 Oligosaccharyl transferaseRN5A 48 kDa subunit Recognition ofS15A2 DNA damage by PCNA-containing replication complex Constitutive SignalingEnergy by NOTCH1 dependent t(7;9)(NOTCH1:M1580_K2555) regulation of mTOR by LKB1-AMPKSignaling Translocation by NOTCH3 Mutant Caspase-mediatedCASP6TNFR1-mediated cleavage of cytoskeletal ceramide proteinsproduction Interferon alpha/beta signaling DCC mediated attractive signalingNef and signal transduction PDE4D Pyrimidine catabolismPackagingRAD52 Of Telomere Ends VLDLR internalisation and degradation Signaling by NOTCH4 CaMKCATL2 IV-mediatedMINK1 phosphorylationMTORAPAF of PTK6CREB promotes HIF1A stabilization MembraneGAK binding and targetting of FCERIGAG proteins mediated MAPK activationCa2+ pathwayKPCZ NICA B2CL1 GolgiMPRI Associated Vesicle Biogenesis KPCG Fc epsilon receptor (FCERI) signaling PDE4CPDE4B Mismatch repairDPOD1 (MMR) directed by MSH2:MSH6 (MutSalpha) 5NTD EYA2 GTR3 CREB phosphorylation CATBthrough the activation of CaMKK PDE5APDE9A Ephrin signaling ITK PDE4A Mismatch repair (MMR) directed byAK1C1 AK1C4MSH2:MSH3 (MutSbeta)PCNA-Dependent Long Patch Base Excision Repair Activated PKN1 stimulatesPLK2 transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 TNIK Formation of apoptosome GSK3ASynthesis of pyrophosphates in the cytosol UFO EukaryoticViral mRNA Translation TranslationRSSA Termination Resolution of Abasic Sites (AP sites) CATL1 LRRK2 Gastrin-CREB signalling pathwayCATH via PKC and AxonalMAPKCD28 growthdependent stimulation PI3K/Akt signaling PP2BAPP2BBLIMK2 Selenocysteine synthesis Termination of translesion DNA synthesis DNA methylation SRBP2 M4K4NuclearTP53 signaling Regulates PI5Pby ERBB4 TranscriptionRegulates TP53 of Death Acetylation Receptors and Ligands BLK SH22A SMG1 SRP-dependent cotranslationalFormation proteinof the Formationternary targeting complex, toof membranea pool and of subsequently, free 40S subunits the 43S complex Synthesis of Prostaglandins (PG)PARP2 and Thromboxanes (TX) WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 KKCC1 ITPK1 CASPAVEGFA-VEGFR2DUS6 Pathway Vasopressin regulates renal water homeostasis via Aquaporins Synthesis of Gap-fillingbile acids and DNA bile repair salts synthesis via 24-hydroxycholesterol andTranslesion ligation in GG-NER synthesis by REV1 SENP1 APEX1 NRIFNLRP1 signals cellCD209 deathEF1A1 from the nucleus TLR9 KGP1 Sema4D induced cell migration and growth-coneADRB2 collapse Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol CPT2 Receptor-typeCDC45 tyrosine-protein phosphatases KDM1A NR1H3 ADA17 Dihydropteridine reductase SORT p38MAPK events NLK Peptide chain elongation ANM5 Intra-Golgi traffic The NLRP1 inflammasomeTyrosine HPPDaminotransferase POLH YAP1- and WWTR1 (TAZ)-stimulatedPPIB gene expression PEN2APH1A CATS PH4H Cation-dependent mannose-6-phosphate receptor Prolyl 4-hydroxylaseCollagen-bindingP4HA1 subunit protein 1alpha-2 VPS35KCC4 Scavenging by Class B Receptors PKA activation S27A5Vitamins B6 activationAOXA to pyridoxal phosphate Loss ofPre-NOTCH Function of ProcessingFBXW7 in Cancer in the Endoplasmic and NOTCH1 Reticulum Signaling Apoptotic cleavageDownregulation of VACHTcell adhesion of ERBB2:ERBB3 proteins signaling FCGR1RHOA PKA activation in glucagon signalling Translesion synthesisFanconi by POLK Anemia PathwayCBR1 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells AOC1 PSN2APH1B Phosphorylation of CD3 and TCR zeta chains AK1C2 NTCP CytosolicANPRB sensorsDefective of pathogen-associated LFNG causes SCDO3 DNA Lysosome Vesicle Biogenesis ResponseSTK26Nef toMediated elevated CD4 platelet Down-regulation cytosolic Ca2+ Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) DualABCBB Incision in GG-NERNTCP2 PTGES PARP1 ANPRA NUAK1 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) TNR1B RHORIOK2 GTPases DisinhibitionActivate WASPs of SNARE and WAVEs formationMYLK RHO GTPases Activate ROCKs MITF DYRK2 AAKG2 The NLRP3 inflammasome KIF5C PADI2 TR10A LIMK1 Rap1 signalling SAE1 AAKB2 PPB1 GRP78 Activation of caspases through apoptosome-mediated cleavage PDE1CActivation of Rac Amine ligand-binding receptors ARL13B-mediated ciliaryPDE6D trafficking of INPP5ESAE2 AbasicResolution sugar-phosphate of AP sites removal via the multiple-nucleotide via the single-nucleotideAAPK2 patch replacementCYH2O-linked glycosylationpathway PORCN of mucins PIN1BCL2 NEC2 MK08 TNR16 RAC1Retrograde neurotrophin signalling Recycling of bile acids and salts Nicotinamide salvaging CATC DAPK1 RegulationERKs of areactin inactivated dynamics for phagocytic cup formation MYH9 Melanin TYRObiosynthesis CDC7DBF4A TristetraprolinDAPK2 (TTP,DAPK3 ZFP36) binds and destabilizes mRNA RHO GTPasesGeneration Activate Rhotekin of second and messenger Rhophilins molecules Cyclic AMP-responsiveTrafficking element-binding XBP1(S)and processing activatesprotein of 1 chaperoneendosomal genes TLR MK07RIOK3CTLA4 inhibitory signaling RHOB SIR6 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain BH3-only proteins associate with and inactivate anti-apoptoticDeoxyribonuclease-2-alphaActivation of BCL-2the CASP3AP-1 members family ofCASP7 transcription factors Apoptotic cleavage of cellular proteins CD28 dependent Vav1 pathwayCASP8Regulation activity by c-FLIP is inhibitedTNF10PAK4PAK5 PCNA RORG RICTR RIOK1 PAK6 Synthesis of bile acidsPOLK and bile salts via 27-hydroxycholesterol ActivationRAD51 of the pre-replicative complexDNM3A Activation of E2F1 target genes at CDK13G1/S VEGFR2 mediated vascular permeability Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein betaDimerization folding of procaspase-8 SUMO is proteolytically processed Nonhomologous End-Joining (NHEJ) TBC/RABGAPsActivation of PPARGC1A (PGC-1alpha) by phosphorylationLigand-independentToll Like Receptor 5caspase (TLR5) Cascadeactivation viaInsulin DCC processing MK14 Sema3A PAK dependent Axon repulsion HDR SUMOthrough is Homologous conjugated toRecombination E1 (UBA2:SAE1) (HRR) Sensing of DNA Double Strand Breaks NOTC1 PLK3 AAKB1 ID1 RHOCD4 GTPases activate PAKs CP27A PGH1 DNA Damage Recognition in GG-NER LOX15 PAR10PARP6 AAKG1 ADP-ribosylation factor 1 DEGS1 PARP4 AAKG3 NOTCH2 intracellular domain regulates transcription FCERA tRNA processing in the mitochondrion IMDH1 LGMN RNF mutants show enhanced WNT signalingTP53 and proliferationRegulates Transcription of CaspaseLEG3 Activators and Caspases DUS3 PDE3B signalling PTN22 PTH1RCRFR1 PTGIS RFA1 Homologous DNA Pairing and Strand Exchange LMBL1 IMDH2 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes NMT2 rRNA processing in the mitochondrion FACD2 Resolution Resolutionof D-loop Structures of D-loop throughStructures Synthesis-Dependent through Holliday Junction Strand Intermediates Annealing (SDSA) PKN1 KSRP (KHSRP) binds and destabilizes mRNA PAK1 ZAP70 CP19ASterols are 12-hydroxylated by CYP8B1 SUMOylationCPT1B of DNA damage response and repair proteins Telomere Extension By Telomerase PRKDC PERK regulates gene expression DisplacementProteinGRAB methylation of DNA glycosylase by APEX1 MP2K7 Translocation of ZAP-70 to Immunological synapse tRNA modification in the mitochondrion SUMO is Negativetransferred regulation from E1 ofto activityE2 (UBE2I, of TFAP2 UBC9) PPARA(AP-2) family activates transcription gene expression factors LKHA4 HG2A DSCAM interactions InactivationUBP18 of Cdc42 and Rac PABP1 WRN InhibitionRegulation of replication of initiationPTEN gene of damaged transcription DNA by RB1/E2F1 Regulation of FZD by ubiquitination Clathrin derived vesicleAKT1 budding CRMPsStimulation in Sema3A of thesignaling cell death response by PAK-2p34 NR1H4 Meiotic HDRsynapsis through Single Strand Annealing (SSA) NAMPT SPHK1 Advanced glycosylationCD209 endproduct (DC-SIGN) receptorsignalingCDC42 signalingTNR1A APEX1-IndependentIRF3-mediated induction Resolution of type Iof IFN AP Sites via the Single Nucleotide Replacement Pathway Regulated proteolysisRetrograde of p75NTR transport at the Trans-Golgi-Network COX reactions POTE1 LOX5 ResolutionDPOLB of AP sites via theMGA single-nucleotide replacementNQO2 pathway Butyrate Response Factor 1 (BRF1) binds and destabilizesNADE mRNA modulates deathERK/MAPK signalling targets FNTA CREB phosphorylation through the activation of Adenylate Cyclase BLM LIPP CHIT1 ULK1 Oxidative Stress Induced Senescence CASP1 DARPP-32 events DNMT1 SP1 NTRK3 NR1H2 EST1 ANM3 FOXO3HLA class I histocompatibility antigen A-3 MAPK3 PDE6ACNRG MK13 HCD2 DNA excision repair protein ERCC-5 DNM3B SUMO1 TP53B IRE1alpha activates chaperones HYEP ARGI1 ELK1 TNF signalingPDE6B CPT1A PRC2 methylates histones and DNA E2AK3 p75NTR negativelyEST2 regulates cell cycle via SC1 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 MK12 Presynaptic phase of homologous DNA pairingPhysiological and strand exchange factors Phase I - FunctionalizationTranscriptional of compounds regulationAAADAL3A1 of pluripotent stem cells Endosomal/Vacuolar pathway SMAD4 MH2 Domain Mutants in Cancer RSK activationMK09 PDPK1 PAK2Nonsense Mediated Decay (NMD) ChromatinenhancedProtein-arginine bymodifying the Exon deiminase Junction type-6 Complex (EJC) PGDH SIRT1 negatively regulates rRNACBX8 Expression AOC3 WNT ligand biogenesis andMDR1 trafficking Activation, myristolyation of BID and translocationMK10 to mitochondria PAK3 PADI1PADI4PADI3 SUMOylation of RNA bindingTranslesion proteins Synthesis by POLH Downregulation of SMAD2/3:SMAD4 transcriptional activity GABA synthesis, release, reuptakeHSP7C and degradation Inactivation, recovery and regulation of the phototransductionKPCB cascade SUMOylationRAD1 of transcriptionHDAC7 factors HSF1 Dickkopf-related proteinCD5R1 1 AKT3 LDL clearanceHLA class II histocompatibility2B11 antigen DRB3-1 BTK NCOA2 Deregulated CDK5 MEN1triggers multiple neurodegenerative pathways in Alzheimer'sPH RUNX3domain disease leucine-rich regulatesmodels BCL2L11 repeat-containing (BIM) transcriptionSMAC-mediated proteinFOXO1 phosphataseMK11 dissociationCASP2 2 of IAP:caspase complexes Synthesis of bile acids and bile salts Activation, translocation and oligomerizationCDK19 of BAX RORATERT Negative regulatorsOncogene of DDX58/IFIH1 InducedPTK6TCF7L2 Senescence Regulates signaling mutants Proteinsdon't bind Involved CTBP AKTin RNA phosphorylates ProcessingMAPK2 AKT-mediated targets in the nucleus inactivationBAD of FOXO1ASMAC binds to IAPs Regulation of PAK-2p34 activity by PS-GAP/RHG10 BRCA1ATR NSD2 SUV91 RCOR1 FOLR1 Inhibition of TSC complex formation byCASP9 PKB Activation of the phototransductionMP2K4 cascade PO2F2 BMAL1:CLOCK,NPAS2KAT5 activates circadian gene expression Regulation of innate immune responsesAcetylcholineNegative to cytosolic regulation Neurotransmitter DNA of TCF-dependent Release signaling Cycle by WNT ligand antagonists PTK6 KS6A2 NCOA1SUMO2 SIK1 HIPK1 ConstitutivePPARG Signaling by NOTCH1 PEST DomainRMTs methylate Mutants histone arginines ActivationKS6A5 of AKT2SignallingMajor pathway to ERK5 of rRNA processing in the nucleolus and cytosol RXRA MED23 Androgen biosynthesis HDAC5 ActivationIRF3 mediated of NOXA activationRegulation and translocation of type of HSF1-mediated 1 IFN to mitochondria heat shock responseESR1 HuR (ELAVL1) binds and stabilizesKS6A3 mRNACD36 TLR5 Toll Like Receptor 4 (TLR4) Cascade UBC9 EZH2 TBK1 TF7L2 CDK5NegativeHS90A regulationAKT2 of theKS6A1 PI3K/AKTInfluenza network Virus Induced ApoptosisKCJ11 Generic TranscriptionScavenging Pathway of heme from plasma ConstitutiveS47A2 SignalingSUZ12 by NOTCH1 HD+PESTERN1 Domain MutantsActivationFABP5 of PUMA and translocation to mitochondria vRNP Assembly MP2K3 DYN2 MyD88 deficiencyRHO GTPases (TLR5) activate KTN1 CASP4M3K8 RS27 HNRPC SUMOylation of chromatin organizationRecruitment proteinsS47A1 and ATM-mediated phosphorylationAssociation of repair of TriC/CCTSMYD3 and signaling with target proteinsRegulation proteins at DNA ofduring TP53 double biosynthesis Expression strand breaks Regulation of TP53 Activity through AssociationNMT1 with Co-factors IRAK4 deficiency (TLR5) CASP8 Transcriptional activationG2/M DNA of damageHDACs mitochondrial checkpoint deacetylate biogenesis histones EED EPH-ephrin mediated repulsionCREB of phosphorylationcellsTGF-beta receptorActivation signaling activates ofDGAT1 DNA SMADs fragmentation factor p75NTR3MG recruits signalling complexes PPARATransport of bile salts and organic acids, metal ions and amine compoundsSETD2 BRD2 RUNX1 regulates transcription of genes involved in BCR signaling Branched-chain amino acid catabolism PPARDSynthesis of 12-eicosatetraenoic acid derivatives HDAC8 SC5A7SETD7 RUNX3 regulates p14-ARFLate Phase of HIV Life Cycle TGFB1 PRP4 HDA10HDAC9 ANM6Cellular hexose transport EPH-ephrin mediated repulsion of cellsTGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) THAS ERR1 CARM1Meiotic recombination HDAC4STF1 SETB1 KS6B2 MAP11 RHO GTPases activate PKNs RecognitionRegulation and of associationTLR by endogenous Cleavageof DNA ligand glycosylase of the damaged with site purine containing an affected purineBCAT2BCAT1 PTBP1 RUNX3 regulates YAP1-mediated transcription CDK8 NCOR1NicotinateNCOR2HDA11 metabolism KLF5ELAV1RegulationDOT1L of TP53 Activity through Phosphorylation Senescence-AssociatedHS90B Secretory Phenotype (SASP)FNTBRK SRC MyD88 dependent cascade initiated on endosome MicroRNA (miRNA) biogenesis SIR5SIR3 KMT5B CDK6 MAP2GRK7 KS6A6 DYN1 Processing of CappedAromatic Intron-Containing amines can bePre-mRNA N-hydroxylated or N-dealkylated by CYP1A2Regulation of lipid metabolism by PeroxisomeActivation proliferator-activated ofSIR4 ATR in response receptor to replication alpha stress(PPARalpha) ABL2 Antigen Presentation: Folding, assembly and peptide loading of class I MHC IRAK4 VxPx cargo-targeting to cilium Abortive elongation of HIV-1 transcriptSF3B3 in the absenceGap-filling of Tat DNA repair synthesismRNA Splicing and ligationFormation - Major in TC-NER Pathwayof Incision Complex in GG-NER HDAC3 HIPK2 SMYD2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Constitutive Signaling by AKT1 E17K in Cancer PTENTNFAMP2K5 TLR7TLR8 ASAP1 FGFR2 alternative splicing SF3B2 Endogenous sterols XAV939 inhibitsRORA tankyrase, activates stabilizinggene expression AXIN SIR1 TranscriptionalCOT2 regulation of white adipocyteRepression differentiationRegulation of WNT target of TP53RUNX1 genes Activity regulatesFactors through involved transcriptionJUN Acetylation in megakaryocyte of genesRAB involvedRegulation GEFs development exchangein ofdifferentiation RUNX1 and GTP Expression platelet forof myeloidGDP productionSMAD2 and on cells ActivityRABs TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Transcriptional regulation by small RNAs Xenobiotics NR4A1 Activating transcription factor 1 ABCC9 TGFBR2 MSI FrameshiftPKA-mediated Mutants in Cancer phosphorylation of CREB KAPCG Viral Messenger RNA SynthesisCP1A2 HDAC2FABPL Role of Abl inCholine Robo-Slit acetylase signalingSynthesis of PCRUNX1 SMAD3 RegulationFormation ofGap PTEN ofjunction annular mRNA degradation gap translation junctions FKB1A ProcessingNR1D1 of DNA double-strand break ends S5A1 ACHG CDO in myogenesisPKN2 KAPCB mRNA Splicing - Minor Pathway Dual incision in TC-NER S5A2 PB1 MRP1 Activation of BAD and translocation to mitochondria Activation of IRF3/IRF7 mediated by TollTBK1/IKK Like Receptor epsilon 7/8 (TLR7/8) Cascade Synthesis of Lipoxins (LX) NR1D1 (REV-ERBA)SMAD2/SMAD3:SMAD4 represses gene expression heterotrimer regulates transcription SMCA2 ACHD KPCT MOGT2 PIWI-interacting RNA (piRNA) biogenesis SC5A2SC5A4HSF1 activation COT1 ATM EHMT1GTR9 IKKE TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling CBP E3 ubiquitin ligases ubiquitinateRUNX1 regulates target proteins transcription of genes involvedSFRP1 in WNT signaling MyD88 cascadeTriglyceride initiated on biosynthesis plasma membrane Interactions of Tat with host cellular proteins Regulation of pyruvate dehydrogenase (PDH)Signaling complex by Retinoic Acid TP53 Regulates Transcription of Genes InvolvedFormation in Cytochromeof the beta-catenin:TCF C Release transactivating complex RUNX1 regulates estrogen receptor mediated transcriptionERAP1ERAP2 RIPK1-mediatedTLR2 regulated necrosis PON1 RPOM BAX Purine ribonucleosideERR2 monophosphateRegulation biosynthesis of TP53 Activity through Methylation ACHE ABL1 Ligand-dependent caspase activation Synthesis of 5-eicosatetraenoic acids ERCC6NOTCH1 (CSB) Intracellular and EHMT2 DomainESR2 (G9a)THB Regulates positively Transcription regulate rRNA expressionCHK1 MDM2 WNT3A Calnexin TNFR1-induced proapoptotic signalingRIPK1M3K1 SMS2 Nuclear ReceptorNotch-HLH transcription transcription pathwayERR3THA pathway HDAC1 TRAF6 mediated IRF7 activation P53 TGFBR1 KD Mutants in CancerTGFBR1 LBD Mutants in Cancer PDK2 TP53LOX12 Regulates TranscriptionSPHK2 of DNA Repair Genes RORB VDR POREDTRAF3-dependentNADKCD38 IRF activation pathway AKT phosphorylatesSMAD2/3 targets in Phosphorylationthe cytosol Motif Mutants in CancerTGFBR2 Kinase Domain Mutants in Cancer PKA-mediated phosphorylationHDL assembly of key metabolic factors PDK1PDK4PDK3 SMS1ACER2KPCD1Sphingolipid de novoMineralocorticoid biosynthesis biosynthesis NR2C2NR4A2HNF4A NLRP3 SMAD2/3 MH2 Domain Mutants in Cancer Toll LikeActivation Receptor TLR6:TLR2of SMO Cascade PausingTat-mediated and recovery HIV elongationof Tat-mediated arrest HIV and elongation recovery RABP2 KPCD2AHR NR0B2 Hemoglobin beta chain ANM1 Attenuation phase CCND2RAB9AReceptor Mediated MitophagyCSK2B Defective ABCC8 can cause hypoglycemias and KAPCAhyperglycemias RNA polymerase II transcribes snRNA genes KPCD3SGPL1Activation of anterior HOX genesMitochondrial in hindbrain transcription development initiation during early embryogenesis RUNX1 interacts with co-factors whose precise effect on RUNX1Viral targets RNP isComplexes not known in the Host Cell Nucleus RXRGRXRBRARG RUNX3 regulates NOTCH signaling EHMT2 Stabilization of p53 Regulation of TP53 Degradation ATP sensitive Potassium channels HMGB1 IRAK4MyD88 deficiency deficiency (TLR2/4) (TLR2/4) HIV elongation arrest and recovery CP17A RUNX1 regulates transcriptionMDM4 of genes involved in interleukin signalingAssembly of Viral Components at the Budding Site Mitochondrial calcium ion transport DGAT2 Pausing and recovery of HIV elongation AL5AP RARARARBARNT Aryl hydrocarbon receptor signalling Pre-NOTCHSynthesis Transcription of Dolichyl-phosphate and PKMTsTranslation methylate histone lysinesCyclin D associated events in G1 RUNX3 regulates CDKN1A transcriptionLIPS RPB1 Synthesis of Hepoxilins (HX) and TrioxilinsLTC4S Synthesis(TrX) of Leukotrienes (LT) and Eoxins (EX) Circadian Clock RUNX1 regulates expression of componentsDeactivation of tightHS71A junctions of the beta-catenin transactivating complex MRP4 IRAK1 GUAAPUR9PUR2 PLIN1FABP4 PP1A PUR6 PEBB Acyl chain remodeling of DAG and TAG CCNT1 CCNK NoRC negatively regulates rRNA expression ActivationDigestion of the TFAP2KAT2B of dietary (AP-2) carbohydratefamily of transcription factorsEP300 PRGR Digestion of dietary lipid SC5A1 Release of Hh-Np from the secreting cell WNT3 MP2K6 MyD88:Mal cascade initiatedToll Like on Receptor plasma TLR1:TLR2membrane Cascade CDK9 SP130 3BHS1 GTR4 CSK21FABPH KCNJ8 S100B 3BHS2KAT8 Urea cycle MAPK5 CSK22 TGFR2 ABCC8 C11B1 CP21AC11B2 TriglycerideFABPI catabolism HATs acetylate histones Class B/2 (Secretin family receptors) SMO TRIF-mediated programmed cell death NCOA3 RUNX3 regulates RUNX1-mediated transcription RegulationDepolymerisation of PTENInlA-mediated localizationof the Nuclear entry Lamina ofFRK Listeria monocytogenes into host cells HDAC6 CSN7B Binding of TCF/LEF:CTNNB1 to target gene promoters Integration of energy metabolism MAP3K8 (TPL2)-dependentToll LikeRegulation Receptor MAPK1/3 of necroptotic 3 activation(TLR3) CascadeCD14cell death FormationFormation of HIV ofelongation RNA Pol complexII elongation in the complex absence of HIV Tat Acrosome Reaction Regulation of gene expression by Hypoxia-inducible Factor Intestinal hexose absorption PP2A-mediated dephosphorylation of PP2AAkey metabolicJNK (c-Jun factors kinases) phosphorylation and activation mediated by activated TICAM1humanTLR3TRAF3 TAK1 deficiencydeficiency deficiency -- HSEHSETransfer - HSE of LPS from LBP carrier to CD14 ACRO KAT2A MPIP3 Serine/threonineLIPR2 protein phosphatase 2A, 55 kDa regulatory subunit B, alpha isoform NOD1/2NF-kB is Signaling activatedNF-kB Pathway activation and signals through survival FADD/RIP-1UNC93B1 pathway deficiency mediated - HSE by caspase-8 and -10 FormationRNA Polymerase of HIV-1 elongation II Transcription complex Elongation containing HIV-1 Tat SUISAMY1LPHAMYP ARGI2 RUNX3 regulatesCEL WNT signaling activated TAK1 mediates p38 MAPK activation RNA PolymeraseTat-mediated II Pre-transcription elongation of the Events HIV-1 transcript LRR FLII-interacting protein 1 (LRRFIP1)CHK2 activates type I IFN production XIAP RNA Polymerase I Transcription Initiation Transcriptional activation of cell cycle inhibitor p21 Initiation ofDownregulation Nuclear Envelope of Reformation TGF-beta receptor signaling RNA Pol II CTD phosphorylation and interaction with CE CHKA MYC CDK4 CCND3 LATS1 Signaling by Hippo TLR3 EicosanoidsFormation of the HIV-1 Early Elongation Complex Peroxisomal lipid metabolism PHOP1 TGFR1 TLR4 RNA Pol II CTDTranscription phosphorylation of the HIV and genome interaction with CE during HIV infection HAOX2 Transcription of E2F targets under negative control by DREAM complex CCND1 LATS2 DEx/H-box helicases activate typeCLEC7A/inflammasome I IFN and inflammatory pathwaycytokines production RNA PolymeraseRNA Polymerase II TranscriptionFormation II Transcription ofInitiation the Early InitiationAnd Elongation Promoter ComplexClearance Glucocorticoid biosynthesis STK3STK4 Ovarian tumor domain proteases LY96 TF2AARNA Polymerase II HIV mRNAPromoter Capping Escape RAGEHedgehog 'off' state RNA PolymeraseHIV Transcription II Promoter Initiation Escape CAH1 MyD88-independent TLR3/TLR4 cascade RNA Polymerase II Transcription Pre-Initiation And Promoter Opening TP53 Regulates Transcription of Genes Involved in G2 CellKMT5A Cycle WDR5Arrest MGLL Netrin-1 signalingPCP/CE pathway CDK7Transcription-Coupled NucleotideFormation Excision of Repair TC-NER (TC-NER) Pre-Incision Complex PTK6ANDR Regulates Cell Cycle 1433E Regulation of TNFR1 signaling CP1B1 CCNH RPA1 RNA CP4ABPolymerase I Transcription Termination DPEP1 Hemoglobin alpha subunit B-WICH complex positivelyDNA regulates Damage/Telomere rRNA expression Stress Induced Senescence HIF1N CP1A1 RNA Polymerase I Chain Elongation KC1G2 Ornithine carbamoyltransferaseHIF1A UBP2 ADCYA RNA Polymerase I Promoter EscapeMAT1 TOP2A ACHB4 UBE2N TOP2B Cyclin EHighly associated sodium events permeableSynthesis during acetylcholine G1/S of PE transitionRAB nicotinic geranylgeranylation receptorsATPB PTK6 Expression Serine/threonine protein phosphatase 2A, 56 kDa regulatoryInterleukin-1 subunit, processing alpha isoform UBP4 DHI2DHI1 SUMOylation of DNA replication proteins MPIP2 Transport of vitamins, nucleosides,ACATN and related molecules TOP1 UBP7 TFAP2MRP3 (AP-2)GCR family regulates transcription of cell cycle factors MHC class II antigen presentation TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependentALR apoptosis remain uncertain CTNB1 VDAC2 TRAF6RIP-mediated mediatedTNFR1-induced NFkB NF-kB activation activationNFkappaB via signaling ZBP1 pathway NFKB1 TRAF6 mediated induction of TAK1 complex Calnexin/calreticulin cycle RIPK2 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation HYES CDN1A KIF5A IKK complexBIRC2 recruitment mediated by RIP1 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)CP4F3 MAX DGLBCristaeMitochondrial formationTranslocation protein import of GLUT4 to the plasma membrane Segment polarity proteinRHO GTPasesdishevelled regulate homolog CFTR DVL-2 trafficking AflatoxinCP4F2 activation and detoxification FormationDGLA of ATP by chemiosmotic coupling CATF TAK1 activates NFkB NOD2by phosphorylation and activation of IKKs complex CP4FC DYR1A CCNE1 APC-Cdc20 mediated degradation of Nek2A CATE Assembly of active LPL and LIPC lipase complexes CFTR NOD1 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) ErythrocytesErythrocytes take take up up carbon oxygen dioxide and release and release carbon oxygen dioxide ABHD6ABD12 KMT2A MARK4 Removal of licensing Arachidonatefactors from origins productionFKBP4 from DAG MissplicedBeta-catenin GSK3beta phosphorylation mutants stabilize cascade beta-catenin GALEGALK1 CDK2 ATPA TCF dependent signalingT41S33 mutants inmutants response of beta-catenin of beta-catenin to WNT aren't aren't phosphorylated phosphorylated S22A7 TP4A2 Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible KC1DFactor1433G Alpha Josephin domain DUBs RGAP1S45 Truncationsmutants of beta-catenin of AMER1 destabilizearen't phosphorylated the destruction complex Galactose catabolism S22AB Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex BAP1 S37AXIN APCmutants missense truncation of beta-catenin mutants mutants destabilizearen't have phosphorylatedimpaired the destruction AXIN binding complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation S22A8 Association of licensing factors with the pre-replicative complexCD11A Disassembly of the destruction complex and recruitment of AXIN to the membrane IRAK1 recruits IKK complex BIRC3 Metalloprotease DUBs EZRI TF65 CP3A4 S22ACS22A6 Cyclin A:Cdk2-associatedTranscription events of E2F at S targetsphase entry under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 TERA GSK3B HSPB1 CP3A5 G0TP53 and Regulates Early G1 Transcription of Genes Involved in G1 CondensationCell Cycle Arrest of Prometaphase CAH9 MPIP1 Miscellaneous substrates Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes CD11B CP2C9CP2J2Fatty acids CP2CI Organic anion transport CCNE2 IRAK2M3K7 mediated activation of TAK1 complex CP2CJCP2C8 VLDL clearance WEE1 Golgi Cisternae Pericentriolar Stack ReorganizationTBB5 KC1E LCAP IKKB CCNA1 Recycling pathway of L1 CP2W1 p53-Dependent G1 DNA Damage Response NEMOTAB1IKBKB deficiency causes SCID CP2AD CP343 COPI-independent Golgi-to-ER retrograde traffic IRAK3 CAH4CAH2 Cyclin A/B1/B2 associated events during G2/M transition Ligand-receptor interactionsFZD1 G2 Phase MASTL Facilitates Mitotic Progression CP2D6 ACHA3 AnchoringEPAS1 of the basal body to the plasma membrane Negative regulation of TCF-dependent signaling by DVL-interactingIKBKG deficiency proteins causes anhidrotic ectodermalIkBA variant dysplasia leads to with EDA-ID immunodeficiency (EDA-ID) (via TLR) CP2B6CP2A6 ACHA4 CCNA2 Recruitment of mitoticLoss centrosome of Nlp from proteins mitotic andcentrosomes complexesKS6A4 HHAT G278V abrogates palmitoylation of Hh-Np NFKB2 CP2E1 ACHB2 Rev-mediated nuclearPP1G export ofXPO1 RHOHIV RNA GTPases Activate Formins KC1A Downstream TCR signalingIKKA CYP2E1 reactions Loss of proteins required for interphase microtubuleNEP/NS2 Interacts organizationBIRC5 with the Cellularfrom the Export centrosome Machinery CAH5A AURKA Activation by TPX2RHO GTPases activate IQGAPs DVL3DVL1 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway CAH7 IDE CAH12 Polo-like kinase mediated events GANAB FACE2 CAH6 Phosphorylation of proteins involved in the G2/M transitionDnaJ by homolog CyclinCDK1Regulation A:Cdc2 subfamilyFKBP5 complexes of PLK1A member Activity 1 at G2/M Transition Reversible hydrationCAH5B ofCAH13 carbonCAH14 dioxide ACHA9 CAH3 ACHA7 Regulation of APC/C activators between G1/S and early anaphaseHSP90OGT1 chaperone cycle for steroid hormone receptors (SHR) MCR COPI-mediatedAmplification anterograde of signal fromtransport unattached kinetochores via a MAD2 inhibitory signal IKBA PYRD NEK2 DCAM SHH Highly calcium permeable nicotinic acetylcholine receptors Condensation of Prophase Chromosomes MK06 Dihydroorotase HyaluronanUb-specific biosynthesis processing andproteases exportMK04 Highly calcium permeable postsynapticACHA nicotinic acetylcholine receptors UMPS SPEE ACHA2ACHA6 PMYT1 Interaction between PHLDA1 and AURKA PLK4 ACHA5NEK9ACHB3 MAPK6/MAPK4 signaling NEK6 AURKA KIF4AAURKB NEK7 E2F-enabled inhibition of pre-replicationPyrimidine complex biosynthesis formation TBA4A UBP5 APC/C:Cdc20 mediated degradationCCNB1 of Cyclin B GEMIRecruitment of NuMA to mitotic centrosomes G2/M DNA replication checkpointMitotic ProphaseMitotic Metaphase/Anaphase Transition TBB4B M3K14 INCE ENASE Nuclear Pore Complex (NPC) Disassembly CCNB2 Resolution of Sister MitoticChromatid Prometaphase Cohesion M3K3 KIF22 N-glycan trimming in the ER and Calnexin/Calreticulin cycle CLC7A KIF11 Activation of NIMA Kinases NEK9, NEK6, NEK7 TBA1A TNR3 Phosphorylation of the APC/C Synthesis of active ubiquitin: roles of E1 andTBB4A E2 enzymes CENPE MRP5 Phosphorylation of Emi1 Metabolism of polyamines TBA1B KIF2C PLK1 FCERI mediated NF-kB activationGLI proteins bind promoters of Hh responsive genes to promote transcription TBB8 TBB2B TAOK1 UCHL1 TBB3 BUB1 VLDL clearance CLEC7A (Dectin-1) signaling COPI-dependentKIF23 Golgi-to-ER retrogradeTBA1C traffic GLI2 TBB1 ABCB5TNKS2TNKS1 GLI1 TBA3E TBB6 MRP7 TBA3CTBB2A MRP6RegulationABCCB of PTEN stability and activityInterleukin-1 family signaling Mitotic Telophase/Cytokinesis Cilium Assembly MRP2 ER-Phagosome pathway Kinesins ABC-family proteins mediated transport Formation of tubulin foldingIntraflagellar intermediates transport by CCT/TriC ULK3 Microtubule-dependent traffickingPost-chaperonin of connexons tubulin from folding Golgi pathway to the plasma membrane CarboxyterminalPrefoldin post-translational mediated transfer modifications of substrate of tubulin to CCT/TriC TTL Gap junction assembly SCF(Skp2)-mediatedRBTN2 degradation of p27/p21 KIFC1 Regulation of RUNX3 expression and activity KI20B The role of GTSE1 in G2/MSeparation progression of Sister after ChromatidsG2 checkpoint RegulationActivation of ofRAS NF-kappaB byCLC4K GAPs in B cells UBA1 EGLN3 AUF1 (hnRNP D0) binds and destabilizes mRNA UCHL3 GLI3 is processedDegradationTNFR2 to ofnon-canonicalGLI3R GLI2 by by the the proteasome NF-kBproteasome pathway RUNX1 regulates transcription of genes involved in differentiationEGLN2Degradation ofUCH HSCs of proteinases beta-catenin by the destruction complex KEAP1 UBA5 Degradation of GLI1 by the proteasome DCOR EGLN1 26S proteosome Ubiquitin Mediated Degradation ofHedgehog Phosphorylated ligand Cdc25AbiogenesisPSA2PSB7 SENP8 PSB8 NQO1 26S proteasome non-ATPase regulatoryPSB1 subunit 14 Neddylation PSA5 Hedgehog 'on' state Dectin-1 mediated noncanonical NF-kB signaling AutodegradationOrc1 removal from of the chromatin E3 ubiquitin ligase COP1PSB4PSB5 PSB11 DegradationCross-presentation of DVLPSB10 of soluble exogenous antigens (endosomes) Ubiquitin-dependent degradationPSA1 of Cyclin D1PSB9 Cdc20:Phospho-APC/C mediated degradationRegulation of of Cyclin activated A PAK-2p34PSA7L by proteasome mediated degradation PSB2PSA4PSA6NIK-->noncanonical NF-kB signaling Oxygen-dependent proline hydroxylation of Hypoxia-inducibleVpu FactorPSA3 mediated Alpha degradation of CD4 SPSB2 PSB3Asymmetric localization of PCP proteins APC/C:Cdh1 mediated degradationAntigen of processing:Cdc20 and Ubiquitinationother APC/C:Cdh1 & ProteasomeDefective targetedPSB6 CFTRPSA7 degradationproteins causes in late cystic mitosis/early fibrosis G1 G2/M Checkpoints Hh mutants that don't undergo autocatalytic processing are degraded by ERAD Degradation of AXINUBA3 CDK-mediatedVHL phosphorylation and removal of Cdc6 SCF-beta-TrCP mediated degradation of Emi1 FBXL7CDT1 down-regulates associationRegulation AURKAwith theVif-mediated duringofCDC6:ORC:origin ornithine mitotic degradation decarboxylase entry complex and ofin APOBEC3Gearly (ODC) mitosis AutodegradationAPC/C:Cdc20 mediatedof Cdh1 by degradation Cdh1:APC/C of Securin